• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • CytoSearch
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Downloads:
  • Precomputed files
  • Archived data
  • Releases (FTP)
  • Genomes (FTP)
  • AAA data (FTP)
  • Lists:
  • Transposons (Dmel)
  • Transposons (other)
  • Vectors & Constructs
  • Anatomical Terms
  • Map Conversion
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Other links:
  • BDGP
  • DGRC
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\par-6

General Information
Symbol	Dmel\par-6	Species	D. melanogaster
Name	par-6	Annotation symbol	CG5884
Feature type	protein_coding_gene	FlyBase ID	FBgn0026192
Gene Model Status	Current	Stock availability	7 publicly available
Also Known As	Par6, DmPar-6, DmPar6, dPar-6, par
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	16C1-16C1	Sequence location	X:17,597,362..17,601,129 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene par-6 is referred to in FlyBase by the symbol Dmel\par-6 (CG5884, FBgn0026192). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding. There is experimental evidence that it is involved in the biological process: regulation of cell shape; synapse assembly; border follicle cell migration; establishment of neuroblast polarity; cell adhesion; asymmetric neuroblast division; branching involved in open tracheal system development; negative regulation of protein kinase activity; phagocytosis, engulfment. 21 alleles are reported. The phenotypes of these alleles are annotated with: embryonic/first instar larval cuticle; embryonic head; trichogen cell; bouton; mesothoracic tergum; terminal tracheal cell; border follicle cell; embryonic/larval cuticle. It has one annotated transcript and one annotated polypeptide. Protein features are: PDZ/DHR/GLGF; Phox/Bem1p. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages, during late larval stages, during early pupal stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1625748_s_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of par-6. Gene sequence location is X:17597362..17601129.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10	Alleles par-6[29VV] par-6[15N] Controlled Vocabulary Terms branching involved in open tracheal system development References Jones and Metzstein, 2011, Genetics 189(1): 153--164 Georgiou and Baum, 2010, J. Cell Sci. 123(7): 1089--1098
FB2012_01	References Stümpges and Behr, 2011, FEBS Lett. 585(20): 3316--3321 Sequence features BKN21111 HFA20359
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 16C1-16C1   Limits computationally determined from genome sequence between P{EP}EP1464 and P{EP}EP970
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)	f (Jones and Metzstein, 2011)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\par-6 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) par-6-RA FBtr0074455  NM_133010   3055   351
Additional Transcript Data & Comments
Reported size (kB)	2.1 (longest cDNA) (Hung and Kemphues, 1999)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein par-6-PA   FBpp0074229   38.5   351   6.76     NP_573238   AAF48757
Additional Polypeptide Data & Comments
Reported size (kDa)	351 (aa) (Hung and Kemphues, 1999)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Phox/Bem1p (IPR000270) PDZ/DHR/GLGF (IPR001478)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA264648   AA438351   AA439157   AA802951   AA816377   AA940678   AA949535   AA952150   AE014298 AAF48757   AF070969 AAD15927   AI403041   AI406166   AW942945   AY061369 AAL28917   BG633678   BG638334   BI163887   BI164470   BI165448   BI172490   BI213602   BI214441   BI227769   BI232101   BI239691   BI239734   BI242479   BI242971   BI243357   BI243688   BI358316   BI358380   BI358415   BI362917   BI367993   BI368742   BI371427   BI371926   BI375383   BI375950   BI484566   BI486611   BI580169   CO153215   CO188162   CO268534   CO273087   CO275336   CO275356   CO278256   CO285488   CO286582   CO288798   CO290700   CO290751   CO291730   CO296546   CO303314   CO304989   CO306422   CO308499   CO321320   CO326287   CO328126   CO329688   CO341455   CZ487930   EC066562   EC072613   EC073378   EC074833   EC080489   EC087134   EC088663   EC195258   EC196469   EC198223   EC199414   EC201709   EC203357   EC204854   EC206995   EC207857   EC209283   EC209527   EC229962   EC231606   EC237075   EC237635   EC238193   EC246926   EC248801   EC254182   EC257158   EC267258   GH752010   GH752388   GH752455   GH753453   GH753984   GH754261   GH754479   GH754604   GH755930   GH756010   GH756911   GH758801   GH758916   GH759096   GH759650   GH759728   GH759736   GH760744   GH760793   GH760912   GH772293   GH773905   GH774782   GH774982   GH775209   GH777477   GH778447   GH778765   GH780121   GH780907   GH781288   GH781389   GH783975   GH784000   GH784104   GH788282   GH788445   GH794629   GH795588   GH796074   GH796313   GH797646   GH799835   GH800292   GH800342   GH801375   GH802850   GH802906   GH803195   GH807393   GH807523   GH807629   GH810266   GH813063   GH813172   GH813964   GH814034   GH816987   GH818382   GH819365   GH820339   GH821533   GH823548   GH824471   GH824833   GH825785   GH826752   GH828175   GH830088   GH830906   GH831775   GH834417   GH834432   GH837853   GH838175   GH839718   GH844961   GH845132   GH845591   GH845816   GH846826   GH847257   GH848818   GH850131   GH850785   GH850987   GH853325   GH855675   GH857736   GH857774   GH858014   GH858753   GH858831   GH860240   GH860775   GH864621   GH864954   GH865371   GH866125   GH866757   GH867594   GH867725   GH868959   GH869356   GH869403   GH869407   GH869413   GH869811   GH869925   GH871211   GH872993   GH873251   GH873431   GH873848   GH875160   GH875657   GH877498   GH877665   GH878011   GH878837   GH879006   GH881514   GH881961   GH884129   GH884466   GH885109   GH888425   GH892904   GH895789   GH896669   GH897298   GH898710   GH900407   GH900865   GH901526   GH901612   GH901761   GH902317   GH904416   GH904632   GH904733   GH906074   GH909642   GH910210   GH910938   GH911404   GH913550   GH915815   GH915923   GH917887   GH918225   GH919921   GH920291   GH921316   GH921677   GH921813   GH922137   GH922413   GH925704   GH927529   GH927760   GH928316   GH928713   GH932906   GH935116   GH935334   GH936962   GH937390   GH937546   GH938038   GH939315
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	O97111
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage   organism | ubiquitous   (Petronczki and Knoblich, 2001) Comment:slightly elevated in developing gut
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage   epithelium   (Petronczki and Knoblich, 2001) Comment:expressed in more cells, but more concentrated in epithelial tissues embryonic stage 5   epithelium   • cytoplasm (Petronczki and Knoblich, 2001) embryonic stage 9 -- 13   epithelium   • apical cortex (Petronczki and Knoblich, 2001) embryonic stage 10   neuroblast   • apical cortex (Petronczki and Knoblich, 2001) Comment:apical crescent at interphase and metaphase; delocalized at interphase embryonic stage 13   somatic cell   (Petronczki and Knoblich, 2001) Comment:expressed in all cells tracheocyte   • apical cortex (Petronczki and Knoblich, 2001) embryonic hindgut   • apical cortex (Petronczki and Knoblich, 2001) embryonic stage 13 -- 17   epithelium   • apical cortex | lateral (Petronczki and Knoblich, 2001) Comment:localized to 2 dots at apicolateral cortex epithelium   • adherens junction | vicinity of (Petronczki and Knoblich, 2001) Comment:2 dots slightly apical to adherens junction third instar larval stage   NMJ bouton   (Yu et al., 2004) motor neuron   • microtubule of presynaptic active zone (Yu et al., 2004) muscle cell   (Yu et al., 2004) Comment:peribouton area pupal stage   eye photoreceptor cell stalk | apical   (Nam and Choi, 2003)
Additional Descriptive Data
	colocalizes with aPKC at presynapse and in muscle, but is also expressed in peribouton area of the muscle where aPKC is absent. (Yu et al., 2004)
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0026192    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0026192 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages, during late larval stages, during early pupal stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0026192 expression level Developmental Stage   Expression Level embryo 00-02hr    3412 embryo 02-04hr    3428 embryo 04-06hr    2401 embryo 06-08hr    2418 embryo 08-10hr    2489 embryo 10-12hr    2064 embryo 12-14hr    1931 embryo 14-16hr    1467 embryo 16-18hr    1523 embryo 18-20hr    822 embryo 20-22hr    1255 embryo 22-24hr    1314 larva L1    521 larva L2    549 larva L3 12hr old    458 larva L3 puffstage 1-2    679 larva L3 puffstage 3-6    1129 larva L3 puffstage 7-9    1638 white prepupae new    2086 white prepupae 12hr    1424 white prepupae 24hr    1494 pupae 2d postWPP    1270 pupae 3d postWPP    759 pupae 4d postWPP    568 adult male 01day    734 adult male 05day    838 adult male 30day    962 adult female 01day    1426 adult female 05day    2393 adult female 30day    2353 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3412) embryo 02-04hr  (3428) embryo 04-06hr  (2401) embryo 06-08hr  (2418) embryo 08-10hr  (2489) embryo 10-12hr  (2064) embryo 12-14hr  (1931) embryo 14-16hr  (1467) embryo 16-18hr  (1523) embryo 18-20hr  (822) embryo 20-22hr  (1255) embryo 22-24hr  (1314) larva L1  (521) larva L2  (549) larva L3 12hr old  (458) larva L3 puffstage 1-2  (679) larva L3 puffstage 3-6  (1129) larva L3 puffstage 7-9  (1638) white prepupae new  (2086) white prepupae 12hr  (1424) white prepupae 24hr  (1494) pupae 2d postWPP  (1270) pupae 3d postWPP  (759) pupae 4d postWPP  (568) adult male 01day  (734) adult male 05day  (838) adult male 30day  (962) adult female 01day  (1426) adult female 05day  (2393) adult female 30day  (2353) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3412) embryo 02-04hr  (3428) embryo 04-06hr  (2401) embryo 06-08hr  (2418) embryo 08-10hr  (2489) embryo 10-12hr  (2064) embryo 12-14hr  (1931) embryo 14-16hr  1467 embryo 16-18hr  (1523) embryo 18-20hr    822 embryo 20-22hr    1255 embryo 22-24hr    1314 larva L1    521 larva L2    549 larva L3 12hr old    458 larva L3 puffstage 1-2    679 larva L3 puffstage 3-6    1129 larva L3 puffstage 7-9  (1638) white prepupae new  (2086) white prepupae 12hr  1424 white prepupae 24hr  1494 pupae 2d postWPP    1270 pupae 3d postWPP    759 pupae 4d postWPP    568 adult male 01day    734 adult male 05day    838 adult male 30day    962 adult female 01day  1426 adult female 05day  (2393) adult female 30day  (2353) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3412 embryo 02-04hr    3428 embryo 04-06hr    2401 embryo 06-08hr    2418 embryo 08-10hr    2489 embryo 10-12hr    2064 embryo 12-14hr    1931 embryo 14-16hr    1467 embryo 16-18hr    1523 embryo 18-20hr    822 embryo 20-22hr    1255 embryo 22-24hr    1314 larva L1    521 larva L2    549 larva L3 12hr old    458 larva L3 puffstage 1-2    679 larva L3 puffstage 3-6    1129 larva L3 puffstage 7-9    1638 white prepupae new    2086 white prepupae 12hr    1424 white prepupae 24hr    1494 pupae 2d postWPP    1270 pupae 3d postWPP    759 pupae 4d postWPP    568 adult male 01day    734 adult male 05day    838 adult male 30day    962 adult female 01day    1426 adult female 05day    2393 adult female 30day    2353 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3412 embryo 02-04hr    3428 embryo 04-06hr    2401 embryo 06-08hr    2418 embryo 08-10hr    2489 embryo 10-12hr    2064 embryo 12-14hr    1931 embryo 14-16hr    1467 embryo 16-18hr    1523 embryo 18-20hr    822 embryo 20-22hr    1255 embryo 22-24hr    1314 larva L1    521 larva L2    549 larva L3 12hr old    458 larva L3 puffstage 1-2    679 larva L3 puffstage 3-6    1129 larva L3 puffstage 7-9    1638 white prepupae new    2086 white prepupae 12hr    1424 white prepupae 24hr    1494 pupae 2d postWPP    1270 pupae 3d postWPP    759 pupae 4d postWPP    568 adult male 01day    734 adult male 05day    838 adult male 30day    962 adult female 01day    1426 adult female 05day    2393 adult female 30day    2353 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0026192 expression level Developmental Stage   Expression Level embryo 00-02hr    3412 embryo 02-04hr    3428 embryo 04-06hr    2401 embryo 06-08hr    2418 embryo 08-10hr    2489 embryo 10-12hr    2064 embryo 12-14hr    1931 embryo 14-16hr    1467 embryo 16-18hr    1523 embryo 18-20hr    822 embryo 20-22hr    1255 embryo 22-24hr    1314 larva L1    521 larva L2    549 larva L3 12hr old    458 larva L3 puffstage 1-2    679 larva L3 puffstage 3-6    1129 larva L3 puffstage 7-9    1638 white prepupae new    2086 white prepupae 12hr    1424 white prepupae 24hr    1494 pupae 2d postWPP    1270 pupae 3d postWPP    759 pupae 4d postWPP    568 adult male 01day    734 adult male 05day    838 adult male 30day    962 adult female 01day    1426 adult female 05day    2393 adult female 30day    2353 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3412) embryo 02-04hr  (3428) embryo 04-06hr  (2401) embryo 06-08hr  (2418) embryo 08-10hr  (2489) embryo 10-12hr  (2064) embryo 12-14hr  (1931) embryo 14-16hr  (1467) embryo 16-18hr  (1523) embryo 18-20hr  (822) embryo 20-22hr  (1255) embryo 22-24hr  (1314) larva L1  (521) larva L2  (549) larva L3 12hr old  (458) larva L3 puffstage 1-2  (679) larva L3 puffstage 3-6  (1129) larva L3 puffstage 7-9  (1638) white prepupae new  (2086) white prepupae 12hr  (1424) white prepupae 24hr  (1494) pupae 2d postWPP  (1270) pupae 3d postWPP  (759) pupae 4d postWPP  (568) adult male 01day  (734) adult male 05day  (838) adult male 30day  (962) adult female 01day  (1426) adult female 05day  (2393) adult female 30day  (2353) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3412) embryo 02-04hr  (3428) embryo 04-06hr  2401 embryo 06-08hr  2418 embryo 08-10hr  (2489) embryo 10-12hr  2064 embryo 12-14hr  1931 embryo 14-16hr  1467 embryo 16-18hr  1523 embryo 18-20hr    822 embryo 20-22hr    1255 embryo 22-24hr    1314 larva L1    521 larva L2    549 larva L3 12hr old    458 larva L3 puffstage 1-2    679 larva L3 puffstage 3-6    1129 larva L3 puffstage 7-9  1638 white prepupae new  2086 white prepupae 12hr  1424 white prepupae 24hr  1494 pupae 2d postWPP    1270 pupae 3d postWPP    759 pupae 4d postWPP    568 adult male 01day    734 adult male 05day    838 adult male 30day    962 adult female 01day  1426 adult female 05day  2393 adult female 30day  2353 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3412 embryo 02-04hr    3428 embryo 04-06hr    2401 embryo 06-08hr    2418 embryo 08-10hr    2489 embryo 10-12hr    2064 embryo 12-14hr    1931 embryo 14-16hr    1467 embryo 16-18hr    1523 embryo 18-20hr    822 embryo 20-22hr    1255 embryo 22-24hr    1314 larva L1    521 larva L2    549 larva L3 12hr old    458 larva L3 puffstage 1-2    679 larva L3 puffstage 3-6    1129 larva L3 puffstage 7-9    1638 white prepupae new    2086 white prepupae 12hr    1424 white prepupae 24hr    1494 pupae 2d postWPP    1270 pupae 3d postWPP    759 pupae 4d postWPP    568 adult male 01day    734 adult male 05day    838 adult male 30day    962 adult female 01day    1426 adult female 05day    2393 adult female 30day    2353 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3412 embryo 02-04hr    3428 embryo 04-06hr    2401 embryo 06-08hr    2418 embryo 08-10hr    2489 embryo 10-12hr    2064 embryo 12-14hr    1931 embryo 14-16hr    1467 embryo 16-18hr    1523 embryo 18-20hr    822 embryo 20-22hr    1255 embryo 22-24hr    1314 larva L1    521 larva L2    549 larva L3 12hr old    458 larva L3 puffstage 1-2    679 larva L3 puffstage 3-6    1129 larva L3 puffstage 7-9    1638 white prepupae new    2086 white prepupae 12hr    1424 white prepupae 24hr    1494 pupae 2d postWPP    1270 pupae 3d postWPP    759 pupae 4d postWPP    568 adult male 01day    734 adult male 05day    838 adult male 30day    962 adult female 01day    1426 adult female 05day    2393 adult female 30day    2353 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0026192    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0026192 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0026192 expression level Tissue   Expression Level Larval Central Nervous System    393.175 Larval Midgut    395.3 Larval Hindgut    455.5 Larval Malpighian Tubules    480.7 Larval Fat Body    337 Larval Salivary Gland    458.8 Larval Trachea    420.425 Larval Carcass    262.675 Adult Head    565.1 Adult Eye    1566.6 Adult Brain    381.1 Adult Thoracic-Abdominal Ganglion    332.1 Adult Crop    305.8 Adult Midgut    258 Adult Hindgut    337.5 Adult Malpighian Tubules    139.6 Adult Fat Body    177.4 Adult Salivary Gland    388 Adult Heart    173.925 Adult VirginFemale Spermatheca    123.2 Adult InseminatedFemale Spermatheca    123.3 Adult Ovary    322.9 Adult Testis    55.1 Adult Male Accessory Gland    208.9 Adult Carcass    267.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    393.175 Larval Midgut    395.3 Larval Hindgut    455.5 Larval Malpighian Tubules    480.7 Larval Fat Body    337 Larval Salivary Gland    458.8 Larval Trachea    420.425 Larval Carcass    262.675 Adult Head  (565.1) Adult Eye  (1566.6) Adult Brain    381.1 Adult Thoracic-Abdominal Ganglion    332.1 Adult Crop    305.8 Adult Midgut    258 Adult Hindgut    337.5 Adult Malpighian Tubules    139.6 Adult Fat Body    177.4 Adult Salivary Gland    388 Adult Heart    173.925 Adult VirginFemale Spermatheca    123.2 Adult InseminatedFemale Spermatheca    123.3 Adult Ovary    322.9 Adult Testis    55.1 Adult Male Accessory Gland    208.9 Adult Carcass    267.4 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    393.175 Larval Midgut    395.3 Larval Hindgut    455.5 Larval Malpighian Tubules    480.7 Larval Fat Body    337 Larval Salivary Gland    458.8 Larval Trachea    420.425 Larval Carcass    262.675 Adult Head    565.1 Adult Eye  (1566.6) Adult Brain    381.1 Adult Thoracic-Abdominal Ganglion    332.1 Adult Crop    305.8 Adult Midgut    258 Adult Hindgut    337.5 Adult Malpighian Tubules    139.6 Adult Fat Body    177.4 Adult Salivary Gland    388 Adult Heart    173.925 Adult VirginFemale Spermatheca    123.2 Adult InseminatedFemale Spermatheca    123.3 Adult Ovary    322.9 Adult Testis    55.1 Adult Male Accessory Gland    208.9 Adult Carcass    267.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    393.175 Larval Midgut    395.3 Larval Hindgut    455.5 Larval Malpighian Tubules    480.7 Larval Fat Body    337 Larval Salivary Gland    458.8 Larval Trachea    420.425 Larval Carcass    262.675 Adult Head    565.1 Adult Eye    1566.6 Adult Brain    381.1 Adult Thoracic-Abdominal Ganglion    332.1 Adult Crop    305.8 Adult Midgut    258 Adult Hindgut    337.5 Adult Malpighian Tubules    139.6 Adult Fat Body    177.4 Adult Salivary Gland    388 Adult Heart    173.925 Adult VirginFemale Spermatheca    123.2 Adult InseminatedFemale Spermatheca    123.3 Adult Ovary    322.9 Adult Testis    55.1 Adult Male Accessory Gland    208.9 Adult Carcass    267.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0026192 expression level Tissue   Expression Level Larval Central Nervous System    393.175 Larval Midgut    395.3 Larval Hindgut    455.5 Larval Malpighian Tubules    480.7 Larval Fat Body    337 Larval Salivary Gland    458.8 Larval Trachea    420.425 Larval Carcass    262.675 Adult Head    565.1 Adult Eye    1566.6 Adult Brain    381.1 Adult Thoracic-Abdominal Ganglion    332.1 Adult Crop    305.8 Adult Midgut    258 Adult Hindgut    337.5 Adult Malpighian Tubules    139.6 Adult Fat Body    177.4 Adult Salivary Gland    388 Adult Heart    173.925 Adult VirginFemale Spermatheca    123.2 Adult InseminatedFemale Spermatheca    123.3 Adult Ovary    322.9 Adult Testis    55.1 Adult Male Accessory Gland    208.9 Adult Carcass    267.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    393.175 Larval Midgut    395.3 Larval Hindgut    455.5 Larval Malpighian Tubules    480.7 Larval Fat Body    337 Larval Salivary Gland    458.8 Larval Trachea    420.425 Larval Carcass    262.675 Adult Head  565.1 Adult Eye  (1566.6) Adult Brain    381.1 Adult Thoracic-Abdominal Ganglion    332.1 Adult Crop    305.8 Adult Midgut    258 Adult Hindgut    337.5 Adult Malpighian Tubules    139.6 Adult Fat Body    177.4 Adult Salivary Gland    388 Adult Heart    173.925 Adult VirginFemale Spermatheca    123.2 Adult InseminatedFemale Spermatheca    123.3 Adult Ovary    322.9 Adult Testis    55.1 Adult Male Accessory Gland    208.9 Adult Carcass    267.4 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    393.175 Larval Midgut    395.3 Larval Hindgut    455.5 Larval Malpighian Tubules    480.7 Larval Fat Body    337 Larval Salivary Gland    458.8 Larval Trachea    420.425 Larval Carcass    262.675 Adult Head    565.1 Adult Eye  1566.6 Adult Brain    381.1 Adult Thoracic-Abdominal Ganglion    332.1 Adult Crop    305.8 Adult Midgut    258 Adult Hindgut    337.5 Adult Malpighian Tubules    139.6 Adult Fat Body    177.4 Adult Salivary Gland    388 Adult Heart    173.925 Adult VirginFemale Spermatheca    123.2 Adult InseminatedFemale Spermatheca    123.3 Adult Ovary    322.9 Adult Testis    55.1 Adult Male Accessory Gland    208.9 Adult Carcass    267.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    393.175 Larval Midgut    395.3 Larval Hindgut    455.5 Larval Malpighian Tubules    480.7 Larval Fat Body    337 Larval Salivary Gland    458.8 Larval Trachea    420.425 Larval Carcass    262.675 Adult Head    565.1 Adult Eye    1566.6 Adult Brain    381.1 Adult Thoracic-Abdominal Ganglion    332.1 Adult Crop    305.8 Adult Midgut    258 Adult Hindgut    337.5 Adult Malpighian Tubules    139.6 Adult Fat Body    177.4 Adult Salivary Gland    388 Adult Heart    173.925 Adult VirginFemale Spermatheca    123.2 Adult InseminatedFemale Spermatheca    123.3 Adult Ovary    322.9 Adult Testis    55.1 Adult Male Accessory Gland    208.9 Adult Carcass    267.4 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    565.1   NA  Eye    1566.6   NA  Brain    381.1   393.175  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    332.1   NA  Crop    305.8   395.3  Midgut    258   455.5  Hindgut    337.5   480.7  Malpighian Tubules    139.6   337  Fat Body    177.4   458.8  Salivary Gland    388   NA  Heart    173.925   420.425  Trachea    NA   NA  VirginFemale Spermatheca    123.2   NA  InseminatedFemale Spermatheca    123.3   NA  Ovary    322.9   NA  Testis    55.1   NA  Male Accessory Gland    208.9   262.675  Carcass    267.4 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_01
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0026192 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5884-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4Act5C.PI par-6dsRNA.Sym.Scer\UAS lethal, with Scer\GAL4αTub84B.PL par-6dsRNA.Sym.Scer\UAS lethal | embryonic stage | recessive par-6Δ219 par-6Δ226 par-6Δ426 lethal | pupal stage, with Scer\GAL4pnr-MD237 par-6GD4048 lethal | recessive par-615N par-629VV semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 par-6GD4048 Other Phenotypes Allele visible, with Scer\GAL4pnr-MD237 par-6GD4048 wild-type par-6+tPa Phenotype manifest in Allele border follicle cell, with Scer\GAL4slbo.2.6 par-6dsRNA.Sym.Scer\UAS par-6Scer\UAS.cKa border follicle cell, with Scer\GAL4slbo.2.6, par-6dsRNA.Sym.Scer\UAS par-6Δ226 border follicle cell, with Scer\GAL4slbo.2.6, par-6Δ226 par-6dsRNA.Sym.Scer\UAS border follicle cell, with Scer\GAL4slbo.2.6, Scer\GAL4upd par-6dsRNA.Sym.Scer\UAS border follicle cell & filopodium | ectopic, with Scer\GAL4slbo.2.6, Scer\GAL4upd par-6dsRNA.Sym.Scer\UAS border follicle cell | somatic clone par-6Δ226 bouton par-6Δ226 egg chamber | germline clone par-6Δ226 embryonic/first instar larval cuticle (with Df(1)par-6Δ226) par-6Δ226 embryonic/larval cuticle par-6Δ226 par-629VV embryonic/larval cuticle (with par-615N) par-629VV embryonic/larval cuticle (with par-629VV) par-615N embryonic head par-615N embryonic neuroblast | germline clone (with Df(1)par-6Δ226) par-6Δ226 epithelial cell | germline clone (with Df(1)par-6Δ226) par-6Δ226 follicle cell | somatic clone par-6Δ226 mesothoracic tergum, with Scer\GAL4pnr-MD237 par-6GD4048 oocyte | germline clone par-6Δ226 terminal tracheal cell, with Scer\GAL4btl.PS par-6GD4048 terminal tracheal cell | somatic clone par-6Δ226 par-629VV par-615N trichogen cell, with Scer\GAL4pnr-MD237 par-6GD4048
Classical Alleles ( 7 )
For All Classical Alleles Show
Allele of par-6 Class Mutagen Stocks Known lesion par-6f05334 piggyBac transposase 1 -- par-6G796 P-element activity 1 -- par-629VV amorphic allele - genetic evidence ethyl methanesulfonate 0 Yes par-615N ethyl methanesulfonate 0 Yes par-6Δ219 P-element activity 0 Yes par-6Δ226 P-element activity 0 Yes par-6Δ426 P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 14 )
For All Alleles Carried on Transgenic Constructs Show
Allele of par-6 Class Mutagen Stocks Known lesion par-6GD4048 in vitro construct - RNAi in vitro construct - regulatory fusion 3 Yes par-6HMS01410 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes par-6KK101015 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes par-6+tPa in vitro construct - genomic fragment 0 Yes par-6dsRNA.Sym.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes par-6ISAA.Scer\UAS.T:Ivir\HA in vitro construct - coding region fusion in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes par-6S34A.Scer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes par-6S34A in vitro construct - amino acid replacement 0 Yes par-6Scer\UAS.cKa in vitro construct - regulatory fusion 0 Yes par-6Scer\UAS.P\T.T:Disc\RFP-mCherry in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes par-6Scer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes par-6Scer\UAS.T:Ivir\HA in vitro construct - coding region fusion in vitro construct - regulatory fusion 0 Yes par-6T:Avic\GFP-EGFP in vitro construct - coding region fusion 0 Yes par-6ΔP in vitro construct - site directed mutagenesis 0 Yes
Aneuploid Aberrations
Disrupted in	Df(1)BK10 (Petronczki and Knoblich, 2001)
Duplicated in	Dp(1;Y)W73 (Petronczki and Knoblich, 2001)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4048} NA P{KK101015} NA P{Sym-par-6} NA P{TRiP.HMS01410} NA P{UAS-par-6.HA} NA P{UAS-par-6.ISSA} NA P{UAS-par-6.K} NA P{UASp-par-6.Cherry} NA characterization construct P{par-6+tPa} NA P{par-6ΔP} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{WH}par-6f05334 NA insertion of mobile activating element P{EP}par-6G796 NA P{GSV1}chasEP-631 NA
Gene Ontology: Function, Process & Cellular Component ( 21 unique terms )
Terms Based on Experimental Evidence ( 11 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with sdt (Wang et al., 2004)
Biological Process
CV term Evidence References
asymmetric neuroblast division inferred from genetic interaction with mts (Ogawa et al., 2009) border follicle cell migration inferred from mutant phenotype (Pinheiro and Montell, 2004, Pinheiro and Montell, 2003) branching involved in open tracheal system development inferred from mutant phenotype (Jones and Metzstein, 2011) cell adhesion inferred from mutant phenotype (Kiger et al., 2003) establishment of neuroblast polarity inferred from mutant phenotype (Atwood et al., 2007) negative regulation of protein kinase activity inferred from direct assay (Chabu and Doe, 2008) phagocytosis, engulfment inferred from mutant phenotype (Stroschein-Stevenson et al., 2006) regulation of cell shape inferred from mutant phenotype (Kiger et al., 2003) synapse assembly inferred from mutant phenotype (Ruiz-Canada et al., 2004)
Cellular Component
CV term Evidence References
apical cortex inferred from direct assay (Siegrist and Doe, 2005)
Terms Based on Predictions or Assertions ( 11 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
apical protein localization non-traceable author statement (Schaefer and Knoblich, 2001) establishment or maintenance of epithelial cell apical/basal polarity non-traceable author statement (Bachmann et al., 2001) traceable author statement (Ahringer, 2003) establishment or maintenance of neuroblast polarity non-traceable author statement (Bachmann et al., 2001) establishment or maintenance of polarity of embryonic epithelium non-traceable author statement (Hong et al., 2001) morphogenesis of a polarized epithelium traceable author statement (Gibson and Perrimon, 2003) oocyte axis specification traceable author statement (Ahringer, 2003) zonula adherens assembly non-traceable author statement (Tepass et al., 2001) traceable author statement (Gibson and Perrimon, 2003)
Cellular Component
CV term Evidence References
apical cortex non-traceable author statement (Hong et al., 2001) apical plasma membrane traceable author statement (Gibson and Perrimon, 2003) cell cortex traceable author statement (Bardin et al., 2004) subapical complex traceable author statement (Medina et al., 2002, Gibson and Perrimon, 2003)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions par-6 allele Gene References par-6Scer\UAS.cKa baz (Pinheiro and Montell, 2004)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 59075 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0026192 DroID - A comprehensive database of gene and protein interactions. • FBgn0026192 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32752
Orthologs
Genome-wide drosophilid orthologs	Dana\GF21116 Dere\GG19128 Dgri\GH12629 Dmoj\GI11043 Dper\GL15988 Dpse\GA19201 Dsec\GM13521 Dsim\GD15678 Dvir\GJ15823 Dwil\GK16408 Dyak\GE17677
Curated drosophilid orthologs	Dpse\GA19201
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL006460-PA Aedes aegypti (mosquito) AGAP010494-PA Anopheles gambiae (mosquito) XP_001120877.1 Apis mellifera (honey bee) XP_001949198.1 Acyrthosiphon pisum (pea aphid) 68643 Branchiostoma floridae (lancelet) BGIBMGA004440-PA Bombyx mori (silk worm) ENSBTAP00000028786 Bos taurus (bovine) CN27735 Caenorhabditis brenneri (small nematode) CBP16343 Caenorhabditis briggsae (nematode) CE28089 Caenorhabditis elegans (worm) ENSCAFP00000016994 Canis familiaris (dog) ENSCINP00000008202 Ciona intestinalis (sea squirt) JA01614 Caenorhabditis japonica (nematode) CPIJ008788 Culex pipens (mosquito) ENSCPOP00000005830 Cavia porcellus (guinea pig) RP04275 Caenorhabditis remanei (nematode) ENSCSAVP00000000191 Ciona savignyi (sedentary tunicate) 148373 Capitella spl (polychaete worm) 230177 Daphnia pulex (daphnia) ENSDARP00000008287 Danio rerio (zebra fish) ENSECAP00000007197 Equus caballus (horse) ENSGACP00000004652 Gymnopilus aculeatus (mushroom) ENSGALP00000022081 Gallus gallus (chicken) 115315 Hypsipyla robusta (cedar shoot borer) ENSP00000360672 Homo sapiens (human) ISCW002459-PA Ixodes scapularis (deer tick) 158981 Lottia gigantea (owl limpet) ENSMODP00000020430 Monodelphis domestica (gray opossum) ENSMMUP00000018026 Macaca mulatta (rhesus monkey) ENSMUSP00000069182 Mus musculus (house mouse) 123088 Nematostella vectensis (starlet anemone) XP_001601910.1 Nasonia vitripennis (wasp) ENSOANP00000013821 Ornithorynchus anatinus (platypus) ENSORLP00000016444 Oryzias latipes (japanese killifish) PHUM003861-PA Pediculus humanus (human body louse) PP05636 Pristionchus pacificus (nematode) ENSPPYP00000012435 Pongo pygmaeus (orangutan) ENSPTRP00000023429 Pan troglodytes (chimpanzee) ENSRNOP00000023801 Rattus norvegicus (norway rat) Smp_048550 Schistosoma mansoni (trematode parasite) XP_001196811.1 Strongylocentrotus purpuratus (purple sea urchin) 14573 Trichoplax adhaerens (metazoa) XP_974307.1 Tribolium castaneum (red flour beetle) ENSTNIP00000000553 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000037802 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000026889 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV14834 LH24150 ISCW002459 FBgn0235125 FBgn0218410 FBgn0203010 FBgn0187340 FBgn0168452 JGI_V11_230177 FBgn0079198 FBgn0153592 FBgn0133806 FBgn0120108 FBgn0111334 FBgn0098121 CPIJ008788 BGIBMGA004440 ACYPI009906 GB15893 AGAP010494 AAEL006460 PB20100 PHUM551890 GLEAN_09924
Stocks & Reagents
Stocks Listed in FlyBase ( 7 )
Bloomington	26600 w* P{EP}par-6G796/FM6, w* 35000 y1 sc* v1; P{TRiP.HMS01410}attP2
Harvard	- PBac{WH}par-6f05334
VDRC	v108560 P{KK101015}VIE-260B v19732 w1118 P{GD4048}v19732 v19731 w1118; P{GD4048}v19731 v19730 w1118; P{GD4048}v19730/TM3
Genomic Clones ( 2 )
	BACR01N10 BACR42I14 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 259 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD29223
Other clones	DPiM_LD29223
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH22401 GH26379 LD01318 LD08317 LD12610 LD13638 LD28369 RE03412 RE04152 RE05351 RE15002 RE19037 RE20253 RE24992 RE28117 RE36258 RE36310 RE39822 RE40481 RE40971 RE41402 RE45052 RE45124 RE45177 RE47608 RE53887 RE54763 RE58312 RE58954 RE63171 RE63858 RE67686 RE70061 RE74314
Other clones	9705 14321 14517 17456 41885 42030 66758 70505 80076 80589 105763 119106 121008 124269 144835 153958 162517 190985 214411.42 214531.28 522174 CK01.34A.F3 CK01.45A.A10 CK01.60A.G10 CK01.96B.B6 CK01.96C.G10 CK01.120B.F2 EK037926 EK063259 EK069407 EK074839 EK075057 EK091853 EK109453 EK117151 EK117258 EK129452 EK169102 EK198048 EK213943 EK240949 EK246849 EK251017 EK258521 EK290808 EK293524 EN01513 EP03601 EP08620 EP12458 GM06629 LD22757 RP003025340 RP003035885 RP003036301 RP003045304 RP003048877 RP003049628 RP003049929 RP003050494 RP003053857 RP003072282 RP003074462 RP003083151 RP003088353 RP003092491 RP003093878 RP003096574 RP003096705 RP003105505 RP003112535 RP003115963 RP003120206 RP003123778 RP003125190 RP003126175 RP003131136 RP003139002 RP003140796 RP003143063 RP003147283 RP003147676 RP003149157 RP003149975 RP003153355 RP003153416 RP003161386 RP003162243 RP003170454 RP003174342 RP003178749 RP003185102 RP003188062 RP003189353 RP003193462 RP003195156 RP003198510 RP003199617 RP003205253 RP003206534 RP003207897 RP003212781 RP003216980 RP003219207 RP003220539 RP003225023 RP003232136 RP003233421 RP003237964 RP003237980 RP003239177 RP003241091 RP003244630 RP003245486 RP003248867 RP003250551 RP003250801 RP003254082 RP003257893 RP003257964 RP003258504 RP003262048 RP003262231 RP003264461 RP003267557 RP003267682 RP003267690 RP003272884 RP003283343 RP003284466 RP003289532 RP003292139 RP003294177 RP003295257 RP003295485 RP003298163 RP003299377 RP003301306 RP003301668 RP003302349 RP003311386 RP003311925 RP003312061 RP003313818 RP003314558 RP003319136 RP003319759 RP003322305 RP003322468 RP003324715 RP003328510 RP003331511 RP003334089 RP003334810 RP003334836 RP003335899 RP003337462 RP003348566 RP003352862 RP003356943 RP003361281 RP003362620 RP003365628 RP003367864 RP003369828 RP003370618 RP003373326 RP003373771 RP003375657 RP003384722 RP003386491 RP003395114 RP003409046 RP003417125 RP003422825 RP003424579 RP003431218 RP003435876 RP003436449 RP003438518 RP003450501 RP003459654 RP003473756 RP003484884 RP003486095 RP003486887 RP003496865 RP003504445 RP003507479 RP003515559 RP003532682 RP003536022 RP003538641 RP003547286 RP003556554 RP003557567 RP003557747 RP003560530 RP003570860 RP003579190 RP003580097 RP003589886 RP003595957 RP003611664 RP003612412 RP003616660 RP003620269 RP003620816 RP003621166 RP003623742 RP003631145 RP003635301 RP003636910 RP003639608 RP003652444 RP003656239 RP003656976 RP003659072 RP003663663 RP003671903 RP003671970 RP003676070 RP003676073
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0026192 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32752
Antibody Information
	polyclonal (Yu et al., 2004, Wirtz-Peitz et al., 2008, Petronczki and Knoblich, 2001, Kim et al., 2009)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells. (Stroschein-Stevenson et al., 2006) RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in S2R+ cells: cells become round and detached. Kc167 cells are unaffected. (Kiger et al., 2003) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) baz and par-6 proteins are interdependent for their asymmetric localisation at the apical cell cortex of epithelial cells and neuroblasts in the embryo. (Petronczki and Knoblich, 2001)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_133010 RefSeq (Proteins) • NP_573238 DDBJ / EMBL / GenBank • AA264648 AA952150 AAD15927 AAF48757 AAL28917 AF070969 AW942945 AY061369 CZ487930 Entrez Gene - A searchable database of RefSeq genes. • 32752 UniProtKB/TrEMBL • O97111
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Phox/Bem1p (IPR000270) PDZ/DHR/GLGF (IPR001478)
Linkouts
	BioGRID - A database of protein and genetic interactions • 59075 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0026192 DroID - A comprehensive database of gene and protein interactions. • FBgn0026192 DRSC - Results from RNAi screens. • FBgn0026192 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0026192 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5884-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0026192 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32752 InParanoid A subset of ortholog calls from InParanoid. • AAEL006460-PA Aedes aegypti (mosquito) AGAP010494-PA Anopheles gambiae (mosquito) XP_001120877.1 Apis mellifera (honey bee) XP_001949198.1 Acyrthosiphon pisum (pea aphid) 68643 Branchiostoma floridae (lancelet) BGIBMGA004440-PA Bombyx mori (silk worm) ENSBTAP00000028786 Bos taurus (bovine) CN27735 Caenorhabditis brenneri (small nematode) CBP16343 Caenorhabditis briggsae (nematode) CE28089 Caenorhabditis elegans (worm) ENSCAFP00000016994 Canis familiaris (dog) ENSCINP00000008202 Ciona intestinalis (sea squirt) JA01614 Caenorhabditis japonica (nematode) CPIJ008788 Culex pipens (mosquito) ENSCPOP00000005830 Cavia porcellus (guinea pig) RP04275 Caenorhabditis remanei (nematode) ENSCSAVP00000000191 Ciona savignyi (sedentary tunicate) 148373 Capitella spl (polychaete worm) 230177 Daphnia pulex (daphnia) ENSDARP00000008287 Danio rerio (zebra fish) ENSECAP00000007197 Equus caballus (horse) ENSGACP00000004652 Gymnopilus aculeatus (mushroom) ENSGALP00000022081 Gallus gallus (chicken) 115315 Hypsipyla robusta (cedar shoot borer) ENSP00000360672 Homo sapiens (human) ISCW002459-PA Ixodes scapularis (deer tick) 158981 Lottia gigantea (owl limpet) ENSMODP00000020430 Monodelphis domestica (gray opossum) ENSMMUP00000018026 Macaca mulatta (rhesus monkey) ENSMUSP00000069182 Mus musculus (house mouse) 123088 Nematostella vectensis (starlet anemone) XP_001601910.1 Nasonia vitripennis (wasp) ENSOANP00000013821 Ornithorynchus anatinus (platypus) ENSORLP00000016444 Oryzias latipes (japanese killifish) PHUM003861-PA Pediculus humanus (human body louse) PP05636 Pristionchus pacificus (nematode) ENSPPYP00000012435 Pongo pygmaeus (orangutan) ENSPTRP00000023429 Pan troglodytes (chimpanzee) ENSRNOP00000023801 Rattus norvegicus (norway rat) Smp_048550 Schistosoma mansoni (trematode parasite) XP_001196811.1 Strongylocentrotus purpuratus (purple sea urchin) 14573 Trichoplax adhaerens (metazoa) XP_974307.1 Tribolium castaneum (red flour beetle) ENSTNIP00000000553 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000037802 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000026889 Xenopus tropicalis (frog) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /cytoskel/par6-1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32752 modMine - Data generated by the modENCODE project. • FBgn0026192 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV14834 LH24150 ISCW002459 FBgn0235125 FBgn0218410 FBgn0203010 FBgn0187340 FBgn0168452 JGI_V11_230177 FBgn0079198 FBgn0153592 FBgn0133806 FBgn0120108 FBgn0111334 FBgn0098121 CPIJ008788 BGIBMGA004440 ACYPI009906 GB15893 AGAP010494 AAEL006460 PB20100 PHUM551890 GLEAN_09924
Synonyms & Secondary IDs ( 20 )
Reported As
Symbol Synonym	CG5884 (Molnar et al., 2006, Keleman et al., 2009.8.5, Ni et al., 2011.7.19) DmPar-6 (Izumi et al., 2004, Wu and Beitel, 2004, Ruiz-Canada et al., 2004, Mueller and Bossinger, 2003, Skeath and Thor, 2003, Wedlich, 2002, Knust and Bossinger, 2002, Izumi et al., 2003, Hong et al., 2001, Knust, 2001, Bilder, 2001, Blankenship et al., 2006, Speicher et al., 2008, Kempkens et al., 2006) DmPAR-6 (Pinheiro and Montell, 2004, Wodarz and Huttner, 2003, Doe and Bowerman, 2001, Tuxworth and Chia, 2003, Schaefer and Knoblich, 2001, Cox et al., 2001, Ohno, 2001, Petronczki and Knoblich, 2001) DmPar6 (Yu et al., 2003, Bardin et al., 2004, Chia and Yang, 2002, Doe, 2001, Wang et al., 2004, Speicher et al., 2008) Dmpar6 (Rothenberg et al., 2004) Dm-Par-6 (Smith, 2001) dmPar-6 (Bilder, 2001) Dm-Par6 (Stümpges and Behr, 2011) dPar-6 (Justice and Jan, 2003) DPar6 (Medina et al., 2002) DPar-6 (Humbert et al., 2003, Tepass et al., 2001, Berger et al., 2007) dPAR-6 (Burbelo, 2001.7.27, Pirone et al., 2001) par (Wedlich, 2002) Par (Siegrist and Doe, 2005) Par-6 (Wei et al., 2004, Sotillos et al., 2004, Peterson et al., 2004, Betschinger and Knoblich, 2004, Djiane et al., 2006, Ahringer, 2005, Siegrist and Doe, 2005, Wei et al., 2005, Chabu et al., 2007, Wang and Riechmann, 2007, Benhra et al., 2010, Bonaccorsi et al., 2007, Nam and Choi, 2006, Bell et al., 2008, Bulgakova et al., 2008, Chabu and Doe, 2008, Atwood and Prehoda, 2009, Campbell et al., 2009, Franz and Riechmann, 2010, David et al., 2010, Duchi et al., 2010, Letizia et al., 2011) par-6 (Hutterer et al., 2004, Wirtz-Peitz and Knoblich, 2006, Djiane et al., 2005, Gotta, 2005, Wiggin et al., 2005, Stark et al., 2005, Stroschein-Stevenson et al., 2006, Harris and Peifer, 2005, Wodarz, 2002, Jones and Metzstein, 2011, Molnar et al., 2006, Rolls and Doe, 2004, Eulalio et al., 2007, Kind et al., 2008, Wirtz-Peitz et al., 2008, Wang and Riechmann, 2007, Atwood et al., 2007, Dworkin et al., 2009, Courbard et al., 2009, Behm-Ansmant et al., 2006, Ogawa et al., 2009, Kim et al., 2009, Wirtz-Peitz et al., 2008, Doerflinger et al., 2010, Kaplan et al., 2009) Par6 (Sanchez-Soriano et al., 2005, Lee et al., 2006, Izumi et al., 2004, Rolls et al., 2003, Hughes et al., 2004, Rodriguez-Boulan et al., 2004, Harris et al., 2005, Polesello and Payre, 2004, Huynh and St. Johnston, 2004, Hughes et al., 2003, Knoblich et al., 2003, Gibson and Perrimon, 2003, Hidalgo and ffrench-Constant, 2003, Henrique and Schweisguth, 2003, Nelson, 2003, Hughes et al., 2003, Horne-Badovinac and Bilder, 2006, Humbert et al., 2006, Leibfried et al., 2007, Pocha et al., 2011, Harris and Tepass, 2008, Lin, 2008, Chia et al., 2008, Yamashita and Fuller, 2008, Horne-Badovinac and Bilder, 2008, Wang et al., 2009, Warner and Longmore, 2009, Warner et al., 2010, Georgiou and Baum, 2010) PAR6 (Baas et al., 2004, Anderson et al., 2004, Muller, 2003, Zarnescu et al., 2005, Margolis and Borg, 2005) par6 (Horton and Ehlers, 2003, Szafranski and Goode, 2007, Denef et al., 2008, Georgiou et al., 2008, Leibfried et al., 2008, Atwood et al., 2007, Harris and Tepass, 2008, Warner and Longmore, 2009, Walther and Pichaud, 2010, Chang et al., 2010) PAR-6 (Solecki et al., 2006, Harris and Peifer, 2005, Krahn and Wodarz, 2008, Lecuit, 2004, Suzuki and Ohno, 2006, Harris and Peifer, 2007, Morais-de-Sá et al., 2010)
Name Synonym	par-6   Par-6 (Chabu and Doe, 2009)
Secondary FlyBase IDs
References ( 174 )
Generate a list of	All references relating to this gene ( 174 )
List References by type	Research paper  ( 83 ) Supplementary material  ( 5 ) Review  ( 55 ) Personal communication to FlyBase  ( 5 ) Abstract  ( 18 ) FlyBase analysis  ( 1 ) Meeting report  ( 1 ) Computer file  ( 3 ) Conference report  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 14 )
	Jones and Metzstein, 2011, Genetics 189(1): 153--164 A Novel Function for the PAR Complex in Subcellular Morphogenesis of Tracheal Terminal Cells in Drosophila melanogaster. [FBrf0215238] Letizia et al., 2011, J. Cell Sci. 124(2): 240--251 Regulated Crb accumulation controls apical constriction and invagination in Drosophila tracheal cells. [FBrf0212559] Pocha et al., 2011, Curr. Biol. 21(13): 1111--1117 Retromer controls epithelial cell polarity by trafficking the apical determinant crumbs. [FBrf0214250] Stümpges and Behr, 2011, FEBS Lett. 585(20): 3316--3321 Time-specific regulation of airway clearance by the Drosophila J-domain transmembrane protein Wurst. [FBrf0216409] Benhra et al., 2010, Mol. Biol. Cell 21(12): 2078--2086 Neuralized promotes Basal to apical transcytosis of delta in epithelial cells. [FBrf0211002] Chang et al., 2010, Dev. Cell 19(5): 778--785 Interplay between the Transcription Factor Zif and aPKC Regulates Neuroblast Polarity and Self-Renewal. [FBrf0212286] David et al., 2010, Development 137(10): 1645--1655 The PAR complex regulates pulsed actomyosin contractions during amnioserosa apical constriction in Drosophila. [FBrf0210666] Doerflinger et al., 2010, Development 137(10): 1765--1773 Bazooka is required for polarisation of the Drosophila anterior-posterior axis. [FBrf0210668] Duchi et al., 2010, Development 137(9): 1493--1503 Drosophila VHL tumor-suppressor gene regulates epithelial morphogenesis by promoting microtubule and aPKC stability. [FBrf0210606] Franz and Riechmann, 2010, Dev. Biol. 338(2): 136--147 Stepwise polarisation of the Drosophila follicular epithelium. [FBrf0209855] Georgiou and Baum, 2010, J. Cell Sci. 123(7): 1089--1098 Polarity proteins and Rho GTPases cooperate to spatially organise epithelial actin-based protrusions. [FBrf0214990] Morais-de-Sá et al., 2010, Cell 141(3): 509--523 aPKC phosphorylation of Bazooka defines the apical/lateral border in Drosophila epithelial cells. [FBrf0210663] Walther and Pichaud, 2010, Curr. Biol. 20(12): 1065--1074 Crumbs/DaPKC-Dependent Apical Exclusion of Bazooka Promotes Photoreceptor Polarity Remodeling. [FBrf0211169] Warner et al., 2010, Curr. Biol. 20(8): 677--686 The Cdc42/Par6/aPKC Polarity Complex Regulates Apoptosis-Induced Compensatory Proliferation in Epithelia. [FBrf0211164] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...