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Gene Dmel\par-6

General Information
Symbol	Dmel\par-6	Species	D. melanogaster
Name	par-6	Annotation symbol	CG5884
Feature type	protein_coding_gene	FlyBase ID	FBgn0026192
Gene Model Status	Current	Stock availability	10 publicly available
Also Known As	Par6, DmPar-6, DmPar6, dPar-6, par
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	16C1-16C1	Sequence location	X:17,597,385..17,601,129 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene par-6 is referred to in FlyBase by the symbol Dmel\par-6 (CG5884, FBgn0026192). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding. There is experimental evidence for 11 unique biological process terms, many of which group under: biological regulation; regulation of cellular component organization; cellular component organization or biogenesis; system development; cell fate commitment; localization; cellular process; stem cell division; single-organism developmental process; cell proliferation. 24 alleles are reported. The phenotypes of these alleles are annotated with: embryonic/first instar larval cuticle; embryonic head; trichogen cell; bouton; mesothoracic tergum; terminal tracheal cell; border follicle cell; embryonic/larval cuticle. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: PDZ domain; Phox/Bem1p. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages, during late larval stages, during early pupal stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1625748_s_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of par-6. Gene sequence location is X:17597362..17601129.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03	Polypeptides par-6-PB Transcripts par-6-RB
FB2013_02	Controlled Vocabulary Terms positive regulation of filopodium assembly positive regulation of lamellipodium assembly
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 16C1-16C1   Limits computationally determined from genome sequence between P{EP}EP1464 and P{EP}EP970
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)	f (Jones and Metzstein, 2011)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\par-6 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.51
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) par-6-RA FBtr0074455  NM_133010   3032   351 par-6-RB FBtr0074456     2564   351
Additional Transcript Data & Comments
Reported size (kB)	2.1 (longest cDNA) (Hung and Kemphues, 1999)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein par-6-PA   FBpp0074229   38.5   351   6.76     NP_573238   AAF48757 par-6-PB   FBpp0074230   38.5   351   6.76       AAN09592
Additional Polypeptide Data & Comments
Reported size (kDa)	351 (aa) (Hung and Kemphues, 1999)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Phox/Bem1p (IPR000270) PDZ domain (IPR001478)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA264648   AA438351   AA439157   AA802951   AA816377   AA940678   AA949535   AA952150   AE014298 AAF48757   AF070969 AAD15927   AI403041   AI406166   AW942945   AY061369 AAL28917   BG633678   BG638334   BI163887   BI164470   BI165448   BI172490   BI213602   BI214441   BI227769   BI232101   BI239691   BI239734   BI242479   BI242971   BI243357   BI243688   BI358316   BI358380   BI358415   BI362917   BI367993   BI368742   BI371427   BI371926   BI375383   BI375950   BI484566   BI486611   BI580169   CO153215   CO188162   CO268534   CO273087   CO275336   CO275356   CO278256   CO285488   CO286582   CO288798   CO290700   CO290751   CO291730   CO296546   CO303314   CO304989   CO306422   CO308499   CO321320   CO326287   CO328126   CO329688   CO341455   CZ487930   EC066562   EC072613   EC073378   EC074833   EC080489   EC087134   EC088663   EC195258   EC196469   EC198223   EC199414   EC201709   EC203357   EC204854   EC206995   EC207857   EC209283   EC209527   EC229962   EC231606   EC237075   EC237635   EC238193   EC246926   EC248801   EC254182   EC257158   EC267258   GH752010   GH752388   GH752455   GH753453   GH753984   GH754261   GH754479   GH754604   GH755930   GH756010   GH756911   GH758801   GH758916   GH759096   GH759650   GH759728   GH759736   GH760744   GH760793   GH760912   GH772293   GH773905   GH774782   GH774982   GH775209   GH777477   GH778447   GH778765   GH780121   GH780907   GH781288   GH781389   GH783975   GH784000   GH784104   GH788282   GH788445   GH794629   GH795588   GH796074   GH796313   GH797646   GH799835   GH800292   GH800342   GH801375   GH802850   GH802906   GH803195   GH807393   GH807523   GH807629   GH810266   GH813063   GH813172   GH813964   GH814034   GH816987   GH818382   GH819365   GH820339   GH821533   GH823548   GH824471   GH824833   GH825785   GH826752   GH828175   GH830088   GH830906   GH831775   GH834417   GH834432   GH837853   GH838175   GH839718   GH844961   GH845132   GH845591   GH845816   GH846826   GH847257   GH848818   GH850131   GH850785   GH850987   GH853325   GH855675   GH857736   GH857774   GH858014   GH858753   GH858831   GH860240   GH860775   GH864621   GH864954   GH865371   GH866125   GH866757   GH867594   GH867725   GH868959   GH869356   GH869403   GH869407   GH869413   GH869811   GH869925   GH871211   GH872993   GH873251   GH873431   GH873848   GH875160   GH875657   GH877498   GH877665   GH878011   GH878837   GH879006   GH881514   GH881961   GH884129   GH884466   GH885109   GH888425   GH892904   GH895789   GH896669   GH897298   GH898710   GH900407   GH900865   GH901526   GH901612   GH901761   GH902317   GH904416   GH904632   GH904733   GH906074   GH909642   GH910210   GH910938   GH911404   GH913550   GH915815   GH915923   GH917887   GH918225   GH919921   GH920291   GH921316   GH921677   GH921813   GH922137   GH922413   GH925704   GH927529   GH927760   GH928316   GH928713   GH932906   GH935116   GH935334   GH936962   GH937390   GH937546   GH938038   GH939315
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	O97111
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage   organism | ubiquitous   (Petronczki and Knoblich, 2001) Comment:slightly elevated in developing gut
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage   epithelium   (Petronczki and Knoblich, 2001) Comment:expressed in more cells, but more concentrated in epithelial tissues embryonic stage 5   epithelium   • cytoplasm (Petronczki and Knoblich, 2001) embryonic stage 9 -- 13   epithelium   • apical cortex (Petronczki and Knoblich, 2001) embryonic stage 10   neuroblast   • apical cortex (Petronczki and Knoblich, 2001) Comment:apical crescent at interphase and metaphase; delocalized at interphase embryonic stage 13   somatic cell   (Petronczki and Knoblich, 2001) Comment:expressed in all cells tracheocyte   • apical cortex (Petronczki and Knoblich, 2001) embryonic hindgut   • apical cortex (Petronczki and Knoblich, 2001) embryonic stage 13 -- 17   epithelium   • apical cortex | lateral (Petronczki and Knoblich, 2001) Comment:localized to 2 dots at apicolateral cortex epithelium   • adherens junction | vicinity of (Petronczki and Knoblich, 2001) Comment:2 dots slightly apical to adherens junction third instar larval stage   NMJ bouton   (Yu et al., 2004) motor neuron   • microtubule of presynaptic active zone (Yu et al., 2004) muscle cell   (Yu et al., 2004) Comment:peribouton area pupal stage   eye photoreceptor cell stalk | apical   (Nam and Choi, 2003)
Additional Descriptive Data
	colocalizes with aPKC at presynapse and in muscle, but is also expressed in peribouton area of the muscle where aPKC is absent. (Yu et al., 2004)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
apical cortex inferred from direct assay (Siegrist and Doe, 2005)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    393.175 Larval Midgut    395.3 Larval Hindgut    455.5 Larval Malpighian Tubules    480.7 Larval Fat Body    337 Larval Salivary Gland    458.8 Larval Trachea    420.425 Larval Carcass    262.675 Adult Head    565.1 Adult Eye    1566.6 Adult Brain    381.1 Adult Thoracic-Abdominal Ganglion    332.1 Adult Crop    305.8 Adult Midgut    258 Adult Hindgut    337.5 Adult Malpighian Tubules    139.6 Adult Fat Body    177.4 Adult Salivary Gland    388 Adult Heart    173.925 Adult VirginFemale Spermatheca    123.2 Adult InseminatedFemale Spermatheca    123.3 Adult Ovary    322.9 Adult Testis    55.1 Adult Male Accessory Gland    208.9 Adult Carcass    267.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    393.175 Larval Midgut    395.3 Larval Hindgut    455.5 Larval Malpighian Tubules    480.7 Larval Fat Body    337 Larval Salivary Gland    458.8 Larval Trachea    420.425 Larval Carcass    262.675 Adult Head  (565.1) Adult Eye  (1566.6) Adult Brain    381.1 Adult Thoracic-Abdominal Ganglion    332.1 Adult Crop    305.8 Adult Midgut    258 Adult Hindgut    337.5 Adult Malpighian Tubules    139.6 Adult Fat Body    177.4 Adult Salivary Gland    388 Adult Heart    173.925 Adult VirginFemale Spermatheca    123.2 Adult InseminatedFemale Spermatheca    123.3 Adult Ovary    322.9 Adult Testis    55.1 Adult Male Accessory Gland    208.9 Adult Carcass    267.4 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    393.175 Larval Midgut    395.3 Larval Hindgut    455.5 Larval Malpighian Tubules    480.7 Larval Fat Body    337 Larval Salivary Gland    458.8 Larval Trachea    420.425 Larval Carcass    262.675 Adult Head    565.1 Adult Eye  (1566.6) Adult Brain    381.1 Adult Thoracic-Abdominal Ganglion    332.1 Adult Crop    305.8 Adult Midgut    258 Adult Hindgut    337.5 Adult Malpighian Tubules    139.6 Adult Fat Body    177.4 Adult Salivary Gland    388 Adult Heart    173.925 Adult VirginFemale Spermatheca    123.2 Adult InseminatedFemale Spermatheca    123.3 Adult Ovary    322.9 Adult Testis    55.1 Adult Male Accessory Gland    208.9 Adult Carcass    267.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    393.175 Larval Midgut    395.3 Larval Hindgut    455.5 Larval Malpighian Tubules    480.7 Larval Fat Body    337 Larval Salivary Gland    458.8 Larval Trachea    420.425 Larval Carcass    262.675 Adult Head    565.1 Adult Eye    1566.6 Adult Brain    381.1 Adult Thoracic-Abdominal Ganglion    332.1 Adult Crop    305.8 Adult Midgut    258 Adult Hindgut    337.5 Adult Malpighian Tubules    139.6 Adult Fat Body    177.4 Adult Salivary Gland    388 Adult Heart    173.925 Adult VirginFemale Spermatheca    123.2 Adult InseminatedFemale Spermatheca    123.3 Adult Ovary    322.9 Adult Testis    55.1 Adult Male Accessory Gland    208.9 Adult Carcass    267.4 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    393.175 Larval Midgut    395.3 Larval Hindgut    455.5 Larval Malpighian Tubules    480.7 Larval Fat Body    337 Larval Salivary Gland    458.8 Larval Trachea    420.425 Larval Carcass    262.675 Adult Head    565.1 Adult Eye    1566.6 Adult Brain    381.1 Adult Thoracic-Abdominal Ganglion    332.1 Adult Crop    305.8 Adult Midgut    258 Adult Hindgut    337.5 Adult Malpighian Tubules    139.6 Adult Fat Body    177.4 Adult Salivary Gland    388 Adult Heart    173.925 Adult VirginFemale Spermatheca    123.2 Adult InseminatedFemale Spermatheca    123.3 Adult Ovary    322.9 Adult Testis    55.1 Adult Male Accessory Gland    208.9 Adult Carcass    267.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    393.175 Larval Midgut    395.3 Larval Hindgut    455.5 Larval Malpighian Tubules    480.7 Larval Fat Body    337 Larval Salivary Gland    458.8 Larval Trachea    420.425 Larval Carcass    262.675 Adult Head  565.1 Adult Eye  (1566.6) Adult Brain    381.1 Adult Thoracic-Abdominal Ganglion    332.1 Adult Crop    305.8 Adult Midgut    258 Adult Hindgut    337.5 Adult Malpighian Tubules    139.6 Adult Fat Body    177.4 Adult Salivary Gland    388 Adult Heart    173.925 Adult VirginFemale Spermatheca    123.2 Adult InseminatedFemale Spermatheca    123.3 Adult Ovary    322.9 Adult Testis    55.1 Adult Male Accessory Gland    208.9 Adult Carcass    267.4 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    393.175 Larval Midgut    395.3 Larval Hindgut    455.5 Larval Malpighian Tubules    480.7 Larval Fat Body    337 Larval Salivary Gland    458.8 Larval Trachea    420.425 Larval Carcass    262.675 Adult Head    565.1 Adult Eye  1566.6 Adult Brain    381.1 Adult Thoracic-Abdominal Ganglion    332.1 Adult Crop    305.8 Adult Midgut    258 Adult Hindgut    337.5 Adult Malpighian Tubules    139.6 Adult Fat Body    177.4 Adult Salivary Gland    388 Adult Heart    173.925 Adult VirginFemale Spermatheca    123.2 Adult InseminatedFemale Spermatheca    123.3 Adult Ovary    322.9 Adult Testis    55.1 Adult Male Accessory Gland    208.9 Adult Carcass    267.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    393.175 Larval Midgut    395.3 Larval Hindgut    455.5 Larval Malpighian Tubules    480.7 Larval Fat Body    337 Larval Salivary Gland    458.8 Larval Trachea    420.425 Larval Carcass    262.675 Adult Head    565.1 Adult Eye    1566.6 Adult Brain    381.1 Adult Thoracic-Abdominal Ganglion    332.1 Adult Crop    305.8 Adult Midgut    258 Adult Hindgut    337.5 Adult Malpighian Tubules    139.6 Adult Fat Body    177.4 Adult Salivary Gland    388 Adult Heart    173.925 Adult VirginFemale Spermatheca    123.2 Adult InseminatedFemale Spermatheca    123.3 Adult Ovary    322.9 Adult Testis    55.1 Adult Male Accessory Gland    208.9 Adult Carcass    267.4 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    565.1   NA  Eye    1566.6   NA  Brain    381.1   393.175  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    332.1   NA  Crop    305.8   395.3  Midgut    258   455.5  Hindgut    337.5   480.7  Malpighian Tubules    139.6   337  Fat Body    177.4   458.8  Salivary Gland    388   NA  Heart    173.925   420.425  Trachea    NA   NA  VirginFemale Spermatheca    123.2   NA  InseminatedFemale Spermatheca    123.3   NA  Ovary    322.9   NA  Testis    55.1   NA  Male Accessory Gland    208.9   262.675  Carcass    267.4 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    21 central nervous system, larvae L3    17 central nervous system, pupae P8    12 head, virgin 1-day female    13 head, virgin 4-day female    17 head, virgin 20-day female    19 head, mated 1-day female    13 head, mated 4-day female    17 head, mated 20-day female    17 head, mated 1-day male    17 head, mated 4-day male    26 head, mated 20-day male    33 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    14 digestive system, larvae L3 wandering    21 digestive system, 1-day adult    9 digestive system, 4-day adult    9 digestive system, 20-day adult    8 fat body, larvae L3 wandering    4 fat body, white prepupae    13 fat body, pupae P8    17 carcass, larvae L3 wandering    18 carcass, 1-day adult    8 carcass, 4-day adult    10 carcass, 20-day adult    10 ovary, virgin 4-day female    44 ovary, mated 4-day female    32 testis, mated 4-day male    7 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    21 central nervous system, larvae L3    17 central nervous system, pupae P8    12 head, virgin 1-day female    13 head, virgin 4-day female    17 head, virgin 20-day female    19 head, mated 1-day female    13 head, mated 4-day female    17 head, mated 20-day female    17 head, mated 1-day male    17 head, mated 4-day male  26 head, mated 20-day male  (33) salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    14 digestive system, larvae L3 wandering    21 digestive system, 1-day adult    9 digestive system, 4-day adult    9 digestive system, 20-day adult    8 fat body, larvae L3 wandering    4 fat body, white prepupae    13 fat body, pupae P8    17 carcass, larvae L3 wandering    18 carcass, 1-day adult    8 carcass, 4-day adult    10 carcass, 20-day adult    10 ovary, virgin 4-day female  (44) ovary, mated 4-day female  (32) testis, mated 4-day male    7 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    21 central nervous system, larvae L3    17 central nervous system, pupae P8    12 head, virgin 1-day female    13 head, virgin 4-day female    17 head, virgin 20-day female    19 head, mated 1-day female    13 head, mated 4-day female    17 head, mated 20-day female    17 head, mated 1-day male    17 head, mated 4-day male    26 head, mated 20-day male    33 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    14 digestive system, larvae L3 wandering    21 digestive system, 1-day adult    9 digestive system, 4-day adult    9 digestive system, 20-day adult    8 fat body, larvae L3 wandering    4 fat body, white prepupae    13 fat body, pupae P8    17 carcass, larvae L3 wandering    18 carcass, 1-day adult    8 carcass, 4-day adult    10 carcass, 20-day adult    10 ovary, virgin 4-day female    44 ovary, mated 4-day female    32 testis, mated 4-day male    7 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    21 central nervous system, larvae L3    17 central nervous system, pupae P8    12 head, virgin 1-day female    13 head, virgin 4-day female    17 head, virgin 20-day female    19 head, mated 1-day female    13 head, mated 4-day female    17 head, mated 20-day female    17 head, mated 1-day male    17 head, mated 4-day male    26 head, mated 20-day male    33 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    14 digestive system, larvae L3 wandering    21 digestive system, 1-day adult    9 digestive system, 4-day adult    9 digestive system, 20-day adult    8 fat body, larvae L3 wandering    4 fat body, white prepupae    13 fat body, pupae P8    17 carcass, larvae L3 wandering    18 carcass, 1-day adult    8 carcass, 4-day adult    10 carcass, 20-day adult    10 ovary, virgin 4-day female    44 ovary, mated 4-day female    32 testis, mated 4-day male    7 accessory gland, mated 4-day male    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    21 central nervous system, larvae L3    17 central nervous system, pupae P8    12 head, virgin 1-day female    13 head, virgin 4-day female    17 head, virgin 20-day female    19 head, mated 1-day female    13 head, mated 4-day female    17 head, mated 20-day female    17 head, mated 1-day male    17 head, mated 4-day male    26 head, mated 20-day male    33 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    14 digestive system, larvae L3 wandering    21 digestive system, 1-day adult    9 digestive system, 4-day adult    9 digestive system, 20-day adult    8 fat body, larvae L3 wandering    4 fat body, white prepupae    13 fat body, pupae P8    17 carcass, larvae L3 wandering    18 carcass, 1-day adult    8 carcass, 4-day adult    10 carcass, 20-day adult    10 ovary, virgin 4-day female    44 ovary, mated 4-day female    32 testis, mated 4-day male    7 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    21 central nervous system, larvae L3    17 central nervous system, pupae P8    12 head, virgin 1-day female    13 head, virgin 4-day female    17 head, virgin 20-day female    19 head, mated 1-day female    13 head, mated 4-day female    17 head, mated 20-day female    17 head, mated 1-day male    17 head, mated 4-day male  26 head, mated 20-day male  (33) salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    14 digestive system, larvae L3 wandering    21 digestive system, 1-day adult    9 digestive system, 4-day adult    9 digestive system, 20-day adult    8 fat body, larvae L3 wandering    4 fat body, white prepupae    13 fat body, pupae P8    17 carcass, larvae L3 wandering    18 carcass, 1-day adult    8 carcass, 4-day adult    10 carcass, 20-day adult    10 ovary, virgin 4-day female  (44) ovary, mated 4-day female  32 testis, mated 4-day male    7 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    21 central nervous system, larvae L3    17 central nervous system, pupae P8    12 head, virgin 1-day female    13 head, virgin 4-day female    17 head, virgin 20-day female    19 head, mated 1-day female    13 head, mated 4-day female    17 head, mated 20-day female    17 head, mated 1-day male    17 head, mated 4-day male    26 head, mated 20-day male    33 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    14 digestive system, larvae L3 wandering    21 digestive system, 1-day adult    9 digestive system, 4-day adult    9 digestive system, 20-day adult    8 fat body, larvae L3 wandering    4 fat body, white prepupae    13 fat body, pupae P8    17 carcass, larvae L3 wandering    18 carcass, 1-day adult    8 carcass, 4-day adult    10 carcass, 20-day adult    10 ovary, virgin 4-day female    44 ovary, mated 4-day female    32 testis, mated 4-day male    7 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    21 central nervous system, larvae L3    17 central nervous system, pupae P8    12 head, virgin 1-day female    13 head, virgin 4-day female    17 head, virgin 20-day female    19 head, mated 1-day female    13 head, mated 4-day female    17 head, mated 20-day female    17 head, mated 1-day male    17 head, mated 4-day male    26 head, mated 20-day male    33 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    14 digestive system, larvae L3 wandering    21 digestive system, 1-day adult    9 digestive system, 4-day adult    9 digestive system, 20-day adult    8 fat body, larvae L3 wandering    4 fat body, white prepupae    13 fat body, pupae P8    17 carcass, larvae L3 wandering    18 carcass, 1-day adult    8 carcass, 4-day adult    10 carcass, 20-day adult    10 ovary, virgin 4-day female    44 ovary, mated 4-day female    32 testis, mated 4-day male    7 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages, during late larval stages, during early pupal stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    45 embryo 02-04hr    45 embryo 04-06hr    32 embryo 06-08hr    32 embryo 08-10hr    33 embryo 10-12hr    27 embryo 12-14hr    26 embryo 14-16hr    19 embryo 16-18hr    20 embryo 18-20hr    11 embryo 20-22hr    17 embryo 22-24hr    17 larva L1    7 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    22 white prepupae new    28 white prepupae 12hr    19 white prepupae 24hr    20 pupae 2d postWPP    17 pupae 3d postWPP    10 pupae 4d postWPP    8 adult male 01day    10 adult male 05day    11 adult male 30day    13 adult female 01day    19 adult female 05day    32 adult female 30day    31 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (45) embryo 02-04hr  (45) embryo 04-06hr  (32) embryo 06-08hr  (32) embryo 08-10hr  (33) embryo 10-12hr  (27) embryo 12-14hr  26 embryo 14-16hr    19 embryo 16-18hr    20 embryo 18-20hr    11 embryo 20-22hr    17 embryo 22-24hr    17 larva L1    7 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    22 white prepupae new  (28) white prepupae 12hr    19 white prepupae 24hr    20 pupae 2d postWPP    17 pupae 3d postWPP    10 pupae 4d postWPP    8 adult male 01day    10 adult male 05day    11 adult male 30day    13 adult female 01day    19 adult female 05day  (32) adult female 30day  (31) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    45 embryo 02-04hr    45 embryo 04-06hr    32 embryo 06-08hr    32 embryo 08-10hr    33 embryo 10-12hr    27 embryo 12-14hr    26 embryo 14-16hr    19 embryo 16-18hr    20 embryo 18-20hr    11 embryo 20-22hr    17 embryo 22-24hr    17 larva L1    7 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    22 white prepupae new    28 white prepupae 12hr    19 white prepupae 24hr    20 pupae 2d postWPP    17 pupae 3d postWPP    10 pupae 4d postWPP    8 adult male 01day    10 adult male 05day    11 adult male 30day    13 adult female 01day    19 adult female 05day    32 adult female 30day    31 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    45 embryo 02-04hr    45 embryo 04-06hr    32 embryo 06-08hr    32 embryo 08-10hr    33 embryo 10-12hr    27 embryo 12-14hr    26 embryo 14-16hr    19 embryo 16-18hr    20 embryo 18-20hr    11 embryo 20-22hr    17 embryo 22-24hr    17 larva L1    7 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    22 white prepupae new    28 white prepupae 12hr    19 white prepupae 24hr    20 pupae 2d postWPP    17 pupae 3d postWPP    10 pupae 4d postWPP    8 adult male 01day    10 adult male 05day    11 adult male 30day    13 adult female 01day    19 adult female 05day    32 adult female 30day    31 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    45 embryo 02-04hr    45 embryo 04-06hr    32 embryo 06-08hr    32 embryo 08-10hr    33 embryo 10-12hr    27 embryo 12-14hr    26 embryo 14-16hr    19 embryo 16-18hr    20 embryo 18-20hr    11 embryo 20-22hr    17 embryo 22-24hr    17 larva L1    7 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    22 white prepupae new    28 white prepupae 12hr    19 white prepupae 24hr    20 pupae 2d postWPP    17 pupae 3d postWPP    10 pupae 4d postWPP    8 adult male 01day    10 adult male 05day    11 adult male 30day    13 adult female 01day    19 adult female 05day    32 adult female 30day    31 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (45) embryo 02-04hr  (45) embryo 04-06hr  32 embryo 06-08hr  32 embryo 08-10hr  (33) embryo 10-12hr  27 embryo 12-14hr  26 embryo 14-16hr    19 embryo 16-18hr    20 embryo 18-20hr    11 embryo 20-22hr    17 embryo 22-24hr    17 larva L1    7 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    22 white prepupae new  28 white prepupae 12hr    19 white prepupae 24hr    20 pupae 2d postWPP    17 pupae 3d postWPP    10 pupae 4d postWPP    8 adult male 01day    10 adult male 05day    11 adult male 30day    13 adult female 01day    19 adult female 05day  32 adult female 30day  31 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    45 embryo 02-04hr    45 embryo 04-06hr    32 embryo 06-08hr    32 embryo 08-10hr    33 embryo 10-12hr    27 embryo 12-14hr    26 embryo 14-16hr    19 embryo 16-18hr    20 embryo 18-20hr    11 embryo 20-22hr    17 embryo 22-24hr    17 larva L1    7 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    22 white prepupae new    28 white prepupae 12hr    19 white prepupae 24hr    20 pupae 2d postWPP    17 pupae 3d postWPP    10 pupae 4d postWPP    8 adult male 01day    10 adult male 05day    11 adult male 30day    13 adult female 01day    19 adult female 05day    32 adult female 30day    31 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    45 embryo 02-04hr    45 embryo 04-06hr    32 embryo 06-08hr    32 embryo 08-10hr    33 embryo 10-12hr    27 embryo 12-14hr    26 embryo 14-16hr    19 embryo 16-18hr    20 embryo 18-20hr    11 embryo 20-22hr    17 embryo 22-24hr    17 larva L1    7 larva L2    7 larva L3 12hr old    6 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    22 white prepupae new    28 white prepupae 12hr    19 white prepupae 24hr    20 pupae 2d postWPP    17 pupae 3d postWPP    10 pupae 4d postWPP    8 adult male 01day    10 adult male 05day    11 adult male 30day    13 adult female 01day    19 adult female 05day    32 adult female 30day    31 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    43 Schneider line 2 Sg4    21 embryonic 1182-4H    37 embryonic GM2    42 embryonic Kc167    97 embryonic S1    34 embryonic S3    24 leg disc CME L1    21 wing disc CME-W2    20 wing disc ML-DmD8    31 wing disc ML-DmD9    24 wing disc ML-DmD16-c3    37 wing disc ML-DmD21    28 wing disc ML-DmD32    28 haltere disc ML-DmD17-c3    42 eye-antennal disc ML-DmD11    23 antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1    35 CNS ML-DmBG2-c2    27 tumorous blood cells mbn2    39 ovary fGS/OSS    32 ovary OSC    60 ovary OSS    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (43) Schneider line 2 Sg4    21 embryonic 1182-4H  (37) embryonic GM2  (42) embryonic Kc167  (97) embryonic S1  (34) embryonic S3    24 leg disc CME L1    21 wing disc CME-W2    20 wing disc ML-DmD8  (31) wing disc ML-DmD9    24 wing disc ML-DmD16-c3  (37) wing disc ML-DmD21  (28) wing disc ML-DmD32  (28) haltere disc ML-DmD17-c3  (42) eye-antennal disc ML-DmD11    23 antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1  (35) CNS ML-DmBG2-c2  (27) tumorous blood cells mbn2  (39) ovary fGS/OSS  (32) ovary OSC  (60) ovary OSS    11 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    43 Schneider line 2 Sg4    21 embryonic 1182-4H    37 embryonic GM2    42 embryonic Kc167    97 embryonic S1    34 embryonic S3    24 leg disc CME L1    21 wing disc CME-W2    20 wing disc ML-DmD8    31 wing disc ML-DmD9    24 wing disc ML-DmD16-c3    37 wing disc ML-DmD21    28 wing disc ML-DmD32    28 haltere disc ML-DmD17-c3    42 eye-antennal disc ML-DmD11    23 antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1    35 CNS ML-DmBG2-c2    27 tumorous blood cells mbn2    39 ovary fGS/OSS    32 ovary OSC    60 ovary OSS    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    43 Schneider line 2 Sg4    21 embryonic 1182-4H    37 embryonic GM2    42 embryonic Kc167    97 embryonic S1    34 embryonic S3    24 leg disc CME L1    21 wing disc CME-W2    20 wing disc ML-DmD8    31 wing disc ML-DmD9    24 wing disc ML-DmD16-c3    37 wing disc ML-DmD21    28 wing disc ML-DmD32    28 haltere disc ML-DmD17-c3    42 eye-antennal disc ML-DmD11    23 antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1    35 CNS ML-DmBG2-c2    27 tumorous blood cells mbn2    39 ovary fGS/OSS    32 ovary OSC    60 ovary OSS    11 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    43 Schneider line 2 Sg4    21 embryonic 1182-4H    37 embryonic GM2    42 embryonic Kc167    97 embryonic S1    34 embryonic S3    24 leg disc CME L1    21 wing disc CME-W2    20 wing disc ML-DmD8    31 wing disc ML-DmD9    24 wing disc ML-DmD16-c3    37 wing disc ML-DmD21    28 wing disc ML-DmD32    28 haltere disc ML-DmD17-c3    42 eye-antennal disc ML-DmD11    23 antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1    35 CNS ML-DmBG2-c2    27 tumorous blood cells mbn2    39 ovary fGS/OSS    32 ovary OSC    60 ovary OSS    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (43) Schneider line 2 Sg4    21 embryonic 1182-4H  (37) embryonic GM2  (42) embryonic Kc167  (97) embryonic S1  (34) embryonic S3    24 leg disc CME L1    21 wing disc CME-W2    20 wing disc ML-DmD8  31 wing disc ML-DmD9    24 wing disc ML-DmD16-c3  (37) wing disc ML-DmD21  28 wing disc ML-DmD32  28 haltere disc ML-DmD17-c3  (42) eye-antennal disc ML-DmD11    23 antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1  (35) CNS ML-DmBG2-c2  27 tumorous blood cells mbn2  (39) ovary fGS/OSS  32 ovary OSC  (60) ovary OSS    11 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    43 Schneider line 2 Sg4    21 embryonic 1182-4H    37 embryonic GM2    42 embryonic Kc167    97 embryonic S1    34 embryonic S3    24 leg disc CME L1    21 wing disc CME-W2    20 wing disc ML-DmD8    31 wing disc ML-DmD9    24 wing disc ML-DmD16-c3    37 wing disc ML-DmD21    28 wing disc ML-DmD32    28 haltere disc ML-DmD17-c3    42 eye-antennal disc ML-DmD11    23 antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1    35 CNS ML-DmBG2-c2    27 tumorous blood cells mbn2    39 ovary fGS/OSS    32 ovary OSC    60 ovary OSS    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    43 Schneider line 2 Sg4    21 embryonic 1182-4H    37 embryonic GM2    42 embryonic Kc167    97 embryonic S1    34 embryonic S3    24 leg disc CME L1    21 wing disc CME-W2    20 wing disc ML-DmD8    31 wing disc ML-DmD9    24 wing disc ML-DmD16-c3    37 wing disc ML-DmD21    28 wing disc ML-DmD32    28 haltere disc ML-DmD17-c3    42 eye-antennal disc ML-DmD11    23 antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1    19 CNS ML-DmBG1-c1    35 CNS ML-DmBG2-c2    27 tumorous blood cells mbn2    39 ovary fGS/OSS    32 ovary OSC    60 ovary OSS    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    12 cold shock, 4-day adult    7 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    25 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    28 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3    27 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    25 Caffeine 25 mg/ml 48 hrs, 4-day adult    13 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    12 cold shock, 4-day adult    7 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    25 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult  (28) Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3  (27) Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    25 Caffeine 25 mg/ml 48 hrs, 4-day adult    13 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    12 cold shock, 4-day adult    7 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    25 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    28 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3    27 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    25 Caffeine 25 mg/ml 48 hrs, 4-day adult    13 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    12 cold shock, 4-day adult    7 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    25 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    28 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3    27 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    25 Caffeine 25 mg/ml 48 hrs, 4-day adult    13 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    12 cold shock, 4-day adult    7 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    25 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    28 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3    27 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    25 Caffeine 25 mg/ml 48 hrs, 4-day adult    13 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    12 cold shock, 4-day adult    7 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    25 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult  28 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3  27 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    25 Caffeine 25 mg/ml 48 hrs, 4-day adult    13 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    12 cold shock, 4-day adult    7 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    25 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    28 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3    27 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    25 Caffeine 25 mg/ml 48 hrs, 4-day adult    13 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    12 cold shock, 4-day adult    7 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    25 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    28 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3    27 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    25 Caffeine 25 mg/ml 48 hrs, 4-day adult    13 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    20 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_01 mE1_20_mRNA_expression_cluster_04
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0026192 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5884-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4Act5C.PI par-6dsRNA.Sym.Scer\UAS lethal, with Scer\GAL4αTub84B.PL par-6dsRNA.Sym.Scer\UAS lethal | embryonic stage | recessive par-6Δ219 par-6Δ226 par-6Δ426 lethal | pupal stage, with Scer\GAL4pnr-MD237 par-6GD4048 lethal | recessive par-615N par-629VV partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237 par-6GD4048 Other Phenotypes Allele visible, with Scer\GAL4pnr-MD237 par-6GD4048 wild-type par-6+tPa Phenotype manifest in Allele border follicle cell, with Scer\GAL4slbo.2.6 par-6dsRNA.Sym.Scer\UAS par-6Scer\UAS.cKa border follicle cell, with Scer\GAL4slbo.2.6, par-6dsRNA.Sym.Scer\UAS par-6Δ226 border follicle cell, with Scer\GAL4slbo.2.6, par-6Δ226 par-6dsRNA.Sym.Scer\UAS border follicle cell, with Scer\GAL4slbo.2.6, Scer\GAL4upd par-6dsRNA.Sym.Scer\UAS border follicle cell & filopodium | ectopic, with Scer\GAL4slbo.2.6, Scer\GAL4upd par-6dsRNA.Sym.Scer\UAS border follicle cell | somatic clone par-6Δ226 bouton par-6Δ226 egg chamber | germline clone par-6Δ226 embryonic/first instar larval cuticle (with Df(1)par-6Δ226) par-6Δ226 embryonic/larval cuticle par-6Δ226 par-629VV embryonic/larval cuticle (with par-615N) par-629VV embryonic/larval cuticle (with par-629VV) par-615N embryonic head par-615N embryonic neuroblast | germline clone (with Df(1)par-6Δ226) par-6Δ226 epithelial cell | germline clone (with Df(1)par-6Δ226) par-6Δ226 follicle cell | somatic clone par-6Δ226 mesothoracic tergum, with Scer\GAL4pnr-MD237 par-6GD4048 oocyte | germline clone par-6Δ226 terminal tracheal cell, with Scer\GAL4btl.PS par-6GD4048 terminal tracheal cell | somatic clone par-6Δ226 par-629VV par-615N trichogen cell, with Scer\GAL4pnr-MD237 par-6GD4048
Classical Alleles ( 7 )
For All Classical Alleles Show
Allele of par-6 Class Mutagen Stocks Known lesion par-6f05334 piggyBac transposase 1 -- par-6G796 P-element activity 1 -- par-629VV amorphic allele - genetic evidence ethyl methanesulfonate 0 Yes par-615N ethyl methanesulfonate 0 Yes par-6Δ219 P-element activity 0 Yes par-6Δ226 P-element activity 0 Yes par-6Δ426 P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 17 )
For All Alleles Carried on Transgenic Constructs Show
Allele of par-6 Class Mutagen Stocks Known lesion par-6GD4048 in vitro construct - RNAi in vitro construct - regulatory fusion 3 Yes par-6GL00621 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes par-6HMS01410 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes par-6HMS01829 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes par-6HMS01928 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes par-6KK101015 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes par-6+tPa in vitro construct - genomic fragment 0 Yes par-6dsRNA.Sym.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes par-6ISAA.Scer\UAS.T:Ivir\HA1 in vitro construct - coding region fusion in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes par-6S34A.Scer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes par-6S34A in vitro construct - amino acid replacement 0 Yes par-6Scer\UAS.cKa in vitro construct - regulatory fusion 0 Yes par-6Scer\UAS.P\T.T:Disc\RFP-mCherry in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes par-6Scer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes par-6Scer\UAS.T:Ivir\HA1 in vitro construct - coding region fusion in vitro construct - regulatory fusion 0 Yes par-6T:Avic\GFP-EGFP in vitro construct - coding region fusion 0 Yes par-6ΔP in vitro construct - site directed mutagenesis 0 Yes
Aneuploid Aberrations
Disrupted in	Df(1)BK10 (Petronczki and Knoblich, 2001)
Duplicated in	Dp(1;Y)W73 (Petronczki and Knoblich, 2001)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4048} NA P{KK101015} NA P{Sym-par-6} NA P{TRiP.GL00621} NA P{TRiP.HMS01410} NA P{TRiP.HMS01829} NA P{TRiP.HMS01928} NA P{UAS-par-6.HA} NA P{UAS-par-6.ISSA} NA P{UAS-par-6.K} NA P{UASp-par-6.Cherry} NA characterization construct P{par-6+tPa} NA P{par-6ΔP} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{WH}par-6f05334 NA insertion of mobile activating element P{EP}par-6G796 NA P{GSV1}chasEP-631 NA
Gene Ontology: Function, Process & Cellular Component ( 23 unique terms )
Terms Based on Experimental Evidence ( 13 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with sdt (Wang et al., 2004)
Biological Process
CV term Evidence References
asymmetric neuroblast division inferred from genetic interaction with mts (Ogawa et al., 2009) border follicle cell migration inferred from mutant phenotype (Pinheiro and Montell, 2004, Pinheiro and Montell, 2003) branching involved in open tracheal system development inferred from mutant phenotype (Jones and Metzstein, 2011) cell adhesion inferred from mutant phenotype (Kiger et al., 2003) establishment of neuroblast polarity inferred from mutant phenotype (Atwood et al., 2007) negative regulation of protein kinase activity inferred from direct assay (Chabu and Doe, 2008) phagocytosis, engulfment inferred from mutant phenotype (Stroschein-Stevenson et al., 2006) positive regulation of filopodium assembly inferred from mutant phenotype (Georgiou and Baum, 2010) positive regulation of lamellipodium assembly inferred from mutant phenotype (Georgiou and Baum, 2010) regulation of cell shape inferred from mutant phenotype (Kiger et al., 2003) synapse assembly inferred from mutant phenotype (Ruiz-Canada et al., 2004)
Cellular Component
CV term Evidence References
apical cortex inferred from direct assay (Siegrist and Doe, 2005)
Terms Based on Predictions or Assertions ( 11 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
apical protein localization non-traceable author statement (Schaefer and Knoblich, 2001) establishment or maintenance of epithelial cell apical/basal polarity non-traceable author statement (Bachmann et al., 2001) traceable author statement (Ahringer, 2003) establishment or maintenance of neuroblast polarity non-traceable author statement (Bachmann et al., 2001) establishment or maintenance of polarity of embryonic epithelium non-traceable author statement (Hong et al., 2001) morphogenesis of a polarized epithelium traceable author statement (Gibson and Perrimon, 2003) oocyte axis specification traceable author statement (Ahringer, 2003) zonula adherens assembly non-traceable author statement (Tepass et al., 2001) traceable author statement (Gibson and Perrimon, 2003)
Cellular Component
CV term Evidence References
apical cortex non-traceable author statement (Hong et al., 2001) apical plasma membrane traceable author statement (Gibson and Perrimon, 2003) cell cortex traceable author statement (Bardin et al., 2004) subapical complex traceable author statement (Medina et al., 2002, Gibson and Perrimon, 2003)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
par-6 - CG17930 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) par-6 - Cp1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) par-6 - aPKC anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based, western blot (Mintseris et al., 2009.11.23, Guruharsha et al., 2011, Neumüller et al., 2012) par-6 - l(2)gl anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Neumüller et al., 2012, Guruharsha et al., 2011) par-6 - sdt anti tag coimmunoprecipitation, peptide massfingerprinting (Neumüller et al., 2012)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions par-6 allele Gene References par-6Scer\UAS.cKa baz (Pinheiro and Montell, 2004)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 59075 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0026192 DroID - A comprehensive database of gene and protein interactions. • FBgn0026192 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32752 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • O97111
Orthologs
OrthoDB Orthologs (52) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6SQXGT Dipteran inclusive ortholog search EOG6Z62XB Insect inclusive ortholog search EOG634V39 Arthropod inclusive ortholog search EOG6F7M25 Metazoa inclusive ortholog search EOG6MM194
Orthologs in Drosophila Species (EOG6SQXGT)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\par-6     Drosophila simulans   Dsim\GD15678 Y   Drosophila sechellia   Dsec\GM13521 Y   Drosophila erecta   Dere\GG19128 Y   Drosophila yakuba   Dyak\GE17677 Y   Drosophila ananassae   Dana\GF21116 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA19201 Y   Drosophila persimilis   Dper\GL15988 Y   Drosophila willistoni   Dwil\GK16408 Y   Drosophila virilis   Dvir\GJ15823 Y   Drosophila mojavensis   Dmoj\GI11043 Y   Drosophila grimshawi   Dgri\GH12629 Y
Orthologs in non-Drosophila Dipterans (EOG6Z62XB)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL006460   Anopheles gambiae Malaria mosquito  Agam\AGAP010494   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ008788
Orthologs in non-Dipteran Insects (EOG634V39)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\par-6   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG010407   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH24268   Atta cephalotes Leafcutter ant  Acep\ACEP11888   Camponotus floridanus Florida carpenter ant  Cflo\CFLO22167   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL15522   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL22880   Linepithema humile Argentine ant  Lhum\LH24150   Pogonomyrmex barbatus Red harvester ant  Pbar\PB20100   Solenopsis invicta Red fire ant  Sinv\SINV17492   Acyrthosiphon pisum Pea aphid  Apim\ACYPI009906   Bombyx mori Silkmoth  Bmor\BGIBMGA004440   Pediculus humanus Human body louse  Phum\PHUM551890   Tribolium castaneum Red flour beetle  Tcas\TC009924
Orthologs in non-Insect Arthropods (EOG6F7M25)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_230177   Ixodes scapularis Deer tick  Isca\ISCW002459
Orthologs in non-Arthropod Metazoa (EOG6MM194)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\par-6   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_003986gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_026880gn   Danio rerio Zebrafish  Drer\pard6a   Danio rerio Zebrafish  Drer\pard6ga   Danio rerio Zebrafish  Drer\pard6gb   Danio rerio Zebrafish  Drer\pard6b   Xenopus tropicalis Western clawed frog  Xtro\pard6b   Xenopus tropicalis Western clawed frog  Xtro\pard6g   Gallus gallus Domestic chicken  Ggal\PARD6B   Gallus gallus Domestic chicken  Ggal\PARD6A   Gallus gallus Domestic chicken  Ggal\PARD6G   Mus musculus House mouse  Mmus\Pard6b   Mus musculus House mouse  Mmus\Pard6g   Mus musculus House mouse  Mmus\Pard6a   Rattus norvegicus Norway rat  Rnor\Pard6a   Rattus norvegicus Norway rat  Rnor\Pard6g   Rattus norvegicus Norway rat  Rnor\Pard6b   Homo sapiens Human  Hsap\PARD6B   Homo sapiens Human  Hsap\PARD6G   Homo sapiens Human  Hsap\PARD6A
Human Orthologs (3)
Gene OMIM HGNC Hsap\PARD6B     Hsap\PARD6G     Hsap\PARD6A
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD15678 Drosophila sechellia Dsec\GM13521 Drosophila erecta Dere\GG19128 Drosophila yakuba Dyak\GE17677 Drosophila ananassae Dana\GF21116 Drosophila pseudoobscura pseudoobscura Dpse\GA19201 Drosophila persimilis Dper\GL15988 Drosophila willistoni Dwil\GK16408 Drosophila virilis Dvir\GJ15823 Drosophila mojavensis Dmoj\GI11043 Drosophila grimshawi Dgri\GH12629
Stocks & Reagents
Stocks Listed in FlyBase ( 10 )
Bloomington	26600 w* P{EP}par-6G796/FM6, w* 35000 y1 sc* v1; P{TRiP.HMS01410}attP2 37478 y1 sc* v1; P{TRiP.GL00621}attP40 38361 y1 sc* v1; P{TRiP.HMS01829}attP2 39010 y1 sc* v1; P{TRiP.HMS01928}attP40
Harvard	- PBac{WH}par-6f05334
VDRC	v108560 P{KK101015}VIE-260B v19732 w1118 P{GD4048}v19732 v19731 w1118; P{GD4048}v19731 v19730 w1118; P{GD4048}v19730/TM3
Genomic Clones ( 2 )
	BACR01N10 BACR42I14 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 259 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD29223
Other clones	DPiM_LD29223
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH22401 GH26379 LD01318 LD08317 LD12610 LD13638 LD28369 RE03412 RE04152 RE05351 RE15002 RE19037 RE20253 RE24992 RE28117 RE36258 RE36310 RE39822 RE40481 RE40971 RE41402 RE45052 RE45124 RE45177 RE47608 RE53887 RE54763 RE58312 RE58954 RE63171 RE63858 RE67686 RE70061 RE74314
Other clones	9705 14321 14517 17456 41885 42030 66758 70505 80076 80589 105763 119106 121008 124269 144835 153958 162517 190985 214411.42 214531.28 522174 CK01.34A.F3 CK01.45A.A10 CK01.60A.G10 CK01.96B.B6 CK01.96C.G10 CK01.120B.F2 EK037926 EK063259 EK069407 EK074839 EK075057 EK091853 EK109453 EK117151 EK117258 EK129452 EK169102 EK198048 EK213943 EK240949 EK246849 EK251017 EK258521 EK290808 EK293524 EN01513 EP03601 EP08620 EP12458 GM06629 LD22757 RP003025340 RP003035885 RP003036301 RP003045304 RP003048877 RP003049628 RP003049929 RP003050494 RP003053857 RP003072282 RP003074462 RP003083151 RP003088353 RP003092491 RP003093878 RP003096574 RP003096705 RP003105505 RP003112535 RP003115963 RP003120206 RP003123778 RP003125190 RP003126175 RP003131136 RP003139002 RP003140796 RP003143063 RP003147283 RP003147676 RP003149157 RP003149975 RP003153355 RP003153416 RP003161386 RP003162243 RP003170454 RP003174342 RP003178749 RP003185102 RP003188062 RP003189353 RP003193462 RP003195156 RP003198510 RP003199617 RP003205253 RP003206534 RP003207897 RP003212781 RP003216980 RP003219207 RP003220539 RP003225023 RP003232136 RP003233421 RP003237964 RP003237980 RP003239177 RP003241091 RP003244630 RP003245486 RP003248867 RP003250551 RP003250801 RP003254082 RP003257893 RP003257964 RP003258504 RP003262048 RP003262231 RP003264461 RP003267557 RP003267682 RP003267690 RP003272884 RP003283343 RP003284466 RP003289532 RP003292139 RP003294177 RP003295257 RP003295485 RP003298163 RP003299377 RP003301306 RP003301668 RP003302349 RP003311386 RP003311925 RP003312061 RP003313818 RP003314558 RP003319136 RP003319759 RP003322305 RP003322468 RP003324715 RP003328510 RP003331511 RP003334089 RP003334810 RP003334836 RP003335899 RP003337462 RP003348566 RP003352862 RP003356943 RP003361281 RP003362620 RP003365628 RP003367864 RP003369828 RP003370618 RP003373326 RP003373771 RP003375657 RP003384722 RP003386491 RP003395114 RP003409046 RP003417125 RP003422825 RP003424579 RP003431218 RP003435876 RP003436449 RP003438518 RP003450501 RP003459654 RP003473756 RP003484884 RP003486095 RP003486887 RP003496865 RP003504445 RP003507479 RP003515559 RP003532682 RP003536022 RP003538641 RP003547286 RP003556554 RP003557567 RP003557747 RP003560530 RP003570860 RP003579190 RP003580097 RP003589886 RP003595957 RP003611664 RP003612412 RP003616660 RP003620269 RP003620816 RP003621166 RP003623742 RP003631145 RP003635301 RP003636910 RP003639608 RP003652444 RP003656239 RP003656976 RP003659072 RP003663663 RP003671903 RP003671970 RP003676070 RP003676073
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0026192 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32752
Antibody Information
	polyclonal (Yu et al., 2004, Wirtz-Peitz et al., 2008, Petronczki and Knoblich, 2001, Kim et al., 2009)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells. (Stroschein-Stevenson et al., 2006) RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in S2R+ cells: cells become round and detached. Kc167 cells are unaffected. (Kiger et al., 2003) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) baz and par-6 proteins are interdependent for their asymmetric localisation at the apical cell cortex of epithelial cells and neuroblasts in the embryo. (Petronczki and Knoblich, 2001)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_133010 RefSeq (Proteins) • NP_573238 DDBJ / EMBL / GenBank • AA264648 AA952150 AAD15927 AAF48757 AAL28917 AF070969 AW942945 AY061369 CZ487930 Entrez Gene - A searchable database of RefSeq genes. • 32752 UniProtKB/TrEMBL • O97111
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Phox/Bem1p (IPR000270) PDZ domain (IPR001478)
Linkouts
	BioGRID - A database of protein and genetic interactions • 59075 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0026192 DroID - A comprehensive database of gene and protein interactions. • FBgn0026192 DRSC - Results from RNAi screens. • FBgn0026192 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0026192 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5884-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0026192 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32752 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /cytoskel/par6-1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32752 modMine - Data generated by the modENCODE project. • FBgn0026192 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • O97111
Synonyms & Secondary IDs ( 20 )
Reported As
Symbol Synonym	CG5884 (Molnar et al., 2006, Keleman et al., 2009.8.5, Ni et al., 2011.7.19, Ni et al., 2010.12.1) DmPar-6 (Izumi et al., 2004, Wu and Beitel, 2004, Ruiz-Canada et al., 2004, Mueller and Bossinger, 2003, Skeath and Thor, 2003, Wedlich, 2002, Knust and Bossinger, 2002, Izumi et al., 2003, Hong et al., 2001, Knust, 2001, Bilder, 2001, Blankenship et al., 2006, Speicher et al., 2008, Kempkens et al., 2006) DmPAR-6 (Pinheiro and Montell, 2004, Wodarz and Huttner, 2003, Doe and Bowerman, 2001, Tuxworth and Chia, 2003, Schaefer and Knoblich, 2001, Cox et al., 2001, Ohno, 2001, Petronczki and Knoblich, 2001) DmPar6 (Yu et al., 2003, Bardin et al., 2004, Chia and Yang, 2002, Doe, 2001, Wang et al., 2004, Speicher et al., 2008) Dmpar6 (Rothenberg et al., 2003) Dm-Par-6 (Smith, 2001) dmPar-6 (Bilder, 2001) Dm-Par6 (Stümpges and Behr, 2011) dPar-6 (Justice and Jan, 2003) DPar6 (Medina et al., 2002) DPar-6 (Humbert et al., 2003, Tepass et al., 2001, Berger et al., 2007, Bulgakova et al., 2010) dPAR-6 (Burbelo, 2001.7.27, Pirone et al., 2001) par (Wedlich, 2002) Par (Siegrist and Doe, 2005) Par-6 (Wei et al., 2004, Sotillos et al., 2004, Peterson et al., 2004, Betschinger and Knoblich, 2004, Djiane et al., 2006, Ahringer, 2005, Siegrist and Doe, 2005, Wei et al., 2005, Chabu et al., 2007, Wang and Riechmann, 2007, Benhra et al., 2010, Bonaccorsi et al., 2007, Nam and Choi, 2006, Bell et al., 2008, Bulgakova et al., 2010, Bulgakova et al., 2008, Chabu and Doe, 2008, Atwood and Prehoda, 2009, Campbell et al., 2009, Franz and Riechmann, 2010, David et al., 2010, Duchi et al., 2010, Letizia et al., 2011, Gomez et al., 2012, Yoshiura et al., 2012, Whitney et al., 2011, Zhou and Hong, 2012) par-6 (Hutterer et al., 2004, Wirtz-Peitz and Knoblich, 2006, Djiane et al., 2005, Gotta, 2005, Wiggin et al., 2005, Stark et al., 2005, Stroschein-Stevenson et al., 2006, Harris and Peifer, 2005, Wodarz, 2002, Jones and Metzstein, 2011, Molnar et al., 2006, Rolls and Doe, 2004, Eulalio et al., 2007, Zekri et al., 2009, Eulalio et al., 2009, Toku et al., 2011, Kind et al., 2008, Wirtz-Peitz et al., 2008, Wang and Riechmann, 2007, Atwood et al., 2007, Dworkin et al., 2009, Courbard et al., 2009, Behm-Ansmant et al., 2006, Ogawa et al., 2009, Kim et al., 2009, Wirtz-Peitz et al., 2008, Doerflinger et al., 2010, Kaplan et al., 2009, Leibfried et al., 2013, Neumüller et al., 2012, Weber et al., 2012) Par6 (Sanchez-Soriano et al., 2005, Lee et al., 2006, Izumi et al., 2004, Rolls et al., 2003, Hughes et al., 2004, Rodriguez-Boulan et al., 2004, Harris et al., 2005, Polesello and Payre, 2004, Huynh and St. Johnston, 2004, Hughes et al., 2003, Knoblich et al., 2003, Gibson and Perrimon, 2003, Hidalgo and ffrench-Constant, 2003, Henrique and Schweisguth, 2003, Nelson, 2003, Hughes et al., 2003, Horne-Badovinac and Bilder, 2006, Humbert et al., 2006, Leibfried et al., 2007, Fletcher et al., 2012, Pocha et al., 2011, Harris and Tepass, 2008, Lin, 2008, Chia et al., 2008, Yamashita and Fuller, 2008, Horne-Badovinac and Bilder, 2008, Wang et al., 2009, Warner and Longmore, 2009, Warner et al., 2010, Georgiou and Baum, 2010, Seppa et al., 2008, Mathew et al., 2011) PAR6 (Baas et al., 2004, Anderson et al., 2004, Muller, 2003, Zarnescu et al., 2005, Margolis and Borg, 2005, Krahn et al., 2009) par6 (Horton and Ehlers, 2003, Szafranski and Goode, 2007, Denef et al., 2008, Georgiou et al., 2008, Leibfried et al., 2008, Atwood et al., 2007, Harris and Tepass, 2008, Warner and Longmore, 2009, Walther and Pichaud, 2010, Chang et al., 2010) PAR-6 (Solecki et al., 2006, Harris and Peifer, 2005, Krahn and Wodarz, 2008, Lecuit, 2004, Suzuki and Ohno, 2006, Halbsgut et al., 2011, Harris and Peifer, 2007, Sen et al., 2012, Morais-de-Sá et al., 2010, McKinley et al., 2012)
Name Synonym	par-6   Par-6 (Chabu and Doe, 2009)
Secondary FlyBase IDs
References ( 199 )
Generate a list of	All references relating to this gene ( 199 )
List References by type	Research paper  ( 104 ) Supplementary material  ( 7 ) Review  ( 55 ) Personal communication to FlyBase  ( 10 ) Abstract  ( 18 ) FlyBase analysis  ( 1 ) Conference report  ( 2 ) Curated genome annotation  ( 1 )
Recent research papers ( 20 )
	Leibfried et al., 2013, Development 140(2): 362--371 A Cdc42-regulated actin cytoskeleton mediates Drosophila oocyte polarization. [FBrf0220348] Fletcher et al., 2012, Curr. Biol. 22(12): 1116--1122 Positive feedback and mutual antagonism combine to polarize crumbs in the Drosophila follicle cell epithelium. [FBrf0218646] Gomez et al., 2012, J. Cell Biol. 199(7): 1131--1143 Tao controls epithelial morphogenesis by promoting Fasciclin 2 endocytosis. [FBrf0220436] Goulas et al., 2012, Cell Stem Cell 11(4): 529--540 The par complex and integrins direct asymmetric cell division in adult intestinal stem cells. [FBrf0219511] Graybill et al., 2012, J. Biol. Chem. 287(25): 21003--21011 Partitioning-defective protein 6 (Par-6) activates atypical protein kinase C (aPKC) by pseudosubstrate displacement. [FBrf0219298] McKinley et al., 2012, J. Cell Sci. 125(5): 1177--1190 Assembly of Bazooka polarity landmarks through a multifaceted membrane-association mechanism. [FBrf0217991] Neumüller et al., 2012, Genetics 190(3): 931--940 Stringent analysis of gene function and protein-protein interactions using fluorescently tagged genes. [FBrf0217811] Sen et al., 2012, J. Cell Biol. 199(4): 685--698 Drosophila PATJ supports adherens junction stability by modulating Myosin light chain activity. [FBrf0219897] Wandler and Guillemin, 2012, PLoS Pathog. 8(10): e1002939 Transgenic Expression of the Helicobacter pylori Virulence Factor CagA Promotes Apoptosis or Tumorigenesis through JNK Activation in Drosophila. [FBrf0219744] Weber et al., 2012, Genetics 191(1): 145--162 Novel regulators of planar cell polarity: a genetic analysis in Drosophila. [FBrf0218210] Yoshiura et al., 2012, Dev. Cell 22(1): 79--91 Tre1 GPCR Signaling Orients Stem Cell Divisions in the Drosophila Central Nervous System. [FBrf0217269] Zhou and Hong, 2012, Development 139(16): 2891--2896 Drosophila Patj plays a supporting role in apical-basal polarity but is essential for viability. [FBrf0219035] Halbsgut et al., 2011, Mol. Biol. Cell 22(22): 4373--4379 Apical-basal polarity in Drosophila neuroblasts is independent of vesicular trafficking. [FBrf0216808] Jones and Metzstein, 2011, Genetics 189(1): 153--164 A Novel Function for the PAR Complex in Subcellular Morphogenesis of Tracheal Terminal Cells in Drosophila melanogaster. [FBrf0215238] Letizia et al., 2011, J. Cell Sci. 124(2): 240--251 Regulated Crb accumulation controls apical constriction and invagination in Drosophila tracheal cells. [FBrf0212559] Mathew et al., 2011, Mol. Cell. Biol. 31(24): 4978--4993 Role for traf4 in polarizing adherens junctions as a prerequisite for efficient cell shape changes. [FBrf0216703] Pocha et al., 2011, Curr. Biol. 21(13): 1111--1117 Retromer controls epithelial cell polarity by trafficking the apical determinant crumbs. [FBrf0214250] Stümpges and Behr, 2011, FEBS Lett. 585(20): 3316--3321 Time-specific regulation of airway clearance by the Drosophila J-domain transmembrane protein Wurst. [FBrf0216409] Toku et al., 2011, Comput. Biol. Chem. 35(5): 282--292 Reconstruction and crosstalk of protein-protein interaction networks of Wnt and Hedgehog signaling in Drosophila melanogaster. [FBrf0216393] Whitney et al., 2011, Structure 19(11): 1711--1722 A conformational switch in the CRIB-PDZ module of Par-6. [FBrf0217691] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...