A Database of Drosophila Genes & Genomes

FB2008_07, released August 8, 2008
 

Gene Dmel\mei-P26

General Information
SymbolDmel\mei-P26SpeciesD. melanogaster
Namemei-P26Annotation symbolCG12218
Feature typeprotein_coding_geneFlyBase IDFBgn0026206
Created / Updated2003-12-01/2003-12-01
Genomic Location
Chromosome (arm)XRecombination map1-
Cytogenetic map8C15-8C15Sequence locationX:9,057,300..9,065,710 [+]
Map ( GBrowse ) detailed view
hide Summary Information
Automatically generated summary

See sections below for more information
This gene is referred to in FlyBase by the symbol mei-P26 (CG12218, FBgn0026206). It has the cytological map location 8C15. Its sequence location is X:9057300..9065710. Its molecular function is described as: protein binding; zinc ion binding. It is involved in the biological processes: gamete generation; germ cell development; meiosis. 13 alleles are reported. The phenotypes of these alleles are annotated with: nurse cell; testis; egg chamber; egg; spermatozoon; spermatid; ovary; ventral nerve cord; embryonic peripheral nervous system. It has one annotated transcript and one annotated polypeptide.

hide Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
8C15-8C15  
Limits computationally determined from genome sequence between P{EP}EP1450&P{EP}EP1356 and P{EP}EP912EP912  
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
8-8
(determined by in situ hybridisation)  
(Page et al., 2000)
8C-8C
 
(Sekelsky et al., 1999)
8C10-8D3
 
(Page, 1999.3.11)
Experimentally Determined Recombination Data
Location
1-
(Page et al., 1999)
Left of (cM)
(Glasscock et al., 2005)
Right of (cM)
(Glasscock et al., 2005)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology)
References
Gene Order (overall orientation not stated)
References
Overall orientation not stated: His3.3B- Ost48- CG9034- Zpr1- mei-P26+
(Page et al., 2000)
hide Gene Model & Products
Please see the GBrowse view of Dmel\mei-P26 for information on other features
detailed view FBtr0071342 FBtr0071303 FBpp0071277 FBpp0071238 FBti0035248 FBti0039599 FBti0036721 FBti0050538 FBti0055494 FBti0040270 FBti0071500 FBti0027062 FBti0035341 FBti0027252 FBti0021151 FBti0069955 FBti0035760
Comments on Gene Model
hide Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Associated CDS (aa)
mei-P26-RA
FBtr0071303
 NM_143765
  5253
  1189
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
hide Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kD)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
mei-P26-PA  
FBpp0071238  
129.5  
1189  
6.00  
  NP_652022
  AAF46457
Additional Polypeptide Data & Comments
Reported size (kD)
Comments
External Data
Linkouts
PANTHER - Protein classification by function, families, and pathways
•
Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
•
Zinc finger, B-box (IPR000315)
NHL repeat (IPR001258)
Zinc finger, RING-type (IPR001841)
B-box, C-terminal (IPR003649)
NHL repeat, subgroup (IPR013017)
Six-bladed beta-propeller, TolB-like (IPR011042)
hide Sequences Consistent with the Gene Model
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
AA391067
 
AA697533
 
AA950459
 
AA990686
 
AE003446
AAF46457
 
AF145661
AAD38636
 
AI114015
 
AI402222
 
BF486643
 
BF506311
 
BP541882
 
BT025212
 
CO176891
 
CO191163
 
CO192820
 
CO269389
 
CO295871
 
CO296997
 
CO341429
 
CZ476222
 
EC214842
 
EC224722
 
EC243075
 
EL872909
 
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
    Maps to
    Does NOT map to
    Identified with
    (BDGP Project Members, 2000-, Page et al., 2000, Mukai et al., 2006)
    (Page et al., 2000)
    hide Mapped Features & Mutations
    Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here
    Type
    Symbol & Location
    Additional Notes
    References
    point mutation
    mei-P26[16]-1
    X:9,062,576..9,062,576
    comment=One of two amino acid substitutions in mutant
    evidence=experimental
    na_change=C9062576T
    pr_change=S627L|mei-P26-PA
    reported_pr_change=S627L
    (Glasscock et al., 2005)
    point mutation
    mei-P26[16]-2
    X:9,064,235..9,064,235
    comment=One of two amino acid substitutions in mutant; likely cause of mutant phenotype.
    evidence=experimental
    na_change=C9064235T
    pr_change=P1071L|mei-P26-PA
    reported_na_change=C?T
    reported_pr_change=P1071L
    (Glasscock et al., 2005)
    hide External Data
    Linkouts
    DEDB - Drosophila exon database: splicing graphs
    •
    Crossreferences
    hide Expression Data
    FlyBase-Curated Data
    Transcript and
    Protein data     		Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
    hide Summary of Transcript Expression
    Stage
    Tissue/Position
    Reference
    Marker for
      Subcellular Localization
      CV Term
      hide Summary of Polypeptide Expression
      Stage
      Tissue/Position
      Reference
      Marker for
        Subcellular Localization
        CV Term
        hide Microarray Data
        Developmental timecourse, Costello et al., 2008 (Original data from Arbeitman et al., 2002)
        Untitled Document detailed view FBtr0071342 FBtr0071303
        AI114015
        hide External Data & Images
        Linkouts
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        •
        GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies
        •
        BDGP expression data
        •
        Show all BDGP original images, annotations and embryonic microarray data for mei-P26
        FlyExpress - Embryonic expression images (BDGP data)
        •
        Show all FlyExpress processed images for mei-P26
        hide Alleles & Phenotypes
        hide Summary of Allele Phenotypes
        Lethality
        Allele
        viable
        Other Phenotypes
        Allele
        wild-type
        meiotic cell cycle defective
        meiotic cell cycle defective | semidominant
        neurophysiology defective
        neurophysiology defective (with mei-P26fs1)
        neurophysiology defective (with mei-P2616)
        Sterility
        Allele
        sterile
        female sterile | recessive
        male sterile | recessive
        male fertile
        female fertile | reduced
        Phenotype manifest in
        Allele
        nurse cell
        testis
        ventral nerve cord
        embryonic peripheral nervous system
        egg chamber
        egg
        ovary
        spermatozoon
        spermatid
        hide Classical Alleles ( 10 )
        For All Classical Alleles Show

        Allele of mei-P26ClassMutagenStocksKnown lesion
        mei-P26160 Yes
        mei-P261hypomorph0 Yes
        mei-P26d084161 --
        mei-P26fs1hypomorph0 Yes
        mei-P26fs20 Yes
        mei-P26fs30 Yes
        mei-P26fs40 Yes
        mei-P26fs50 Yes
        mei-P26fs60 Yes
        mei-P26mfs10 Yes
        hide Alleles Carried on Transgenic Constructs ( 3 )
        For All Alleles Carried on Transgenic Constructs Show

        Allele of mei-P26ClassMutagenStocksKnown lesion
        mei-P26+t130 Yes
        mei-P26GD75332 Yes
        mei-P26dsRNA.cIa0 Yes
        hide Aneuploid Aberrations
        Useful deficiency
         
        Useful duplication
         
        Disrupted in
        (Page, 1999.3.11, Page et al., 2000, Glasscock et al., 2005)
        (Page et al., 2000, Glasscock et al., 2005)
        (Page et al., 2000)
        Not disrupted in
        (Page, 1999.3.11, Page et al., 2000, Glasscock et al., 2005)
        (Glasscock et al., 2005)
        (Page et al., 2000, Glasscock et al., 2005)
        Duplicated in
        (Page et al., 2000, Glasscock et al., 2005)
        hide Transgenic Constructs & Insertions
        Transgenic Constructs
        Type of construct
        Name
        Expression data
        UAS construct
        P{GD7533}
        NA
        characterization construct
        P{mei-P26+t13}
        NA
        Insertions
        Type of insertions
        Name
        Expression data
        insertion of enhancer trap
        P{lacW}mei-P261
        No
        P{lacW}mei-P26fs1
        No
        P{lacW}mei-P26fs2
        No
        P{lacW}mei-P26fs3
        No
        P{lacW}mei-P26fs4
        No
        P{lacW}mei-P26fs5
        No
        P{lacW}mei-P26fs6
        No
        insertion of mobile activating element
        P{EP}EP1434
        NA
        P{XP}mei-P26d08416
        NA
        hide Related Comments
        Please look at the allele reports for the complete phenotype data
        Mutant females show reduced meiotic recombination.
        (Sekelsky et al., 1999)
        RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.
        (Boutros et al., 2004)
        Mutations in mei-P26 act as suppressors of seizure susceptible mutants.
        (Glasscock et al., 2005)
        hide Gene Ontology: Function, Process & Cellular Component ( 6 )
        hide Molecular Function
        CV term
        Evidence
        References
        protein binding
        inferred from electronic annotation with InterPro:IPR001841
        (FlyBase Curators et al., 2004-)
        zinc ion binding
        inferred from electronic annotation with InterPro:IPR000315, InterPro:IPR001841
        (FlyBase Curators et al., 2004-)
        hide Biological Process
        CV term
        Evidence
        References
        gamete generation
        inferred from mutant phenotype
        (Page et al., 2000)
        germ cell development
        inferred from genetic interaction with FLYBASE:bam; FB:FBgn0000158
        (Page et al., 2000)
        meiosis
        inferred from mutant phenotype
        (Page et al., 2000)
        hide Cellular Component
        CV term
        Evidence
        References
        intracellular
        inferred from electronic annotation with InterPro:IPR000315, InterPro:IPR003649
        (FlyBase Curators et al., 2004-)
        hide Sequence Ontology: Class of Gene
        protein_coding_gene
         
        nuclear_gene
         
        hide Interactions & Pathways
        hide Summary of Genetic Interactions
        Interacts with
        Please look at the allele data for full details of the genetic interactions
        mei-P26 allele
        Gene
        References
        mei-P261
        bam
        (Page et al., 2000)
        unspecified
        eas
        (Glasscock et al., 2005)
        sda
        (Glasscock et al., 2005)
        hide External Data
        Linkouts
        BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions
        •
        hide Orthologs
        Genome-wide drosophilid orthologs
        Curated drosophilid orthologs
         
        Linkouts
        InParanoid orthologs - Eukaryotic orthologs
        •
        hide Functional Complementation between Species
        hide Inter-Species Misexpression Data
        Produces phenotype in
        Produces NO phenotype in
        hide Stocks & Reagents
        hide Stocks Listed in FlyBase ( 4 )
        Szeged
        -
        P{EP}EP1434
        Harvard
        -
        P{XP}mei-P26d08416
        VDRC
        v31693
        w1118; P{GD7533}v31693
        v31695
        w1118; P{GD7533}v31695
        hide Genomic Clones ( 1 )
        hide cDNA Clones ( 15 )
        Please Note
        This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
        cDNA Clones, Fully Sequenced
        BDGP DGC clones
        Other clones
        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        hide RNAi & Array Information
        Affy Oligo
        Linkouts
        DRSC - RNAi screening (Harvard): high-throughput cell culture data and design
        •
        GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data
        •
        hide Antibody Information
        hide Other Information
        hide Discoverer
        hide Etymology
        hide Identification
        hide Position Effect Variegation Data
        hide Relationship to Other Genes
        Source for database identity of
        Source for identity of: mei-P26 CG12218
        (Page, 2001.4.4)
        Source for database merge of
        Source for merge of: mei-P26 BcDNA:GH10646
        (Page et al., 2000)
        Additional comments
        hide Comments About Role
        hide Comments About Molecular Function
        hide Other Comments
        Identification: Defined in a large P-element mutagenesis screen for novel meiotic mutants.
        (Page et al., 1999)
        Identification: In a genetic screen for meiotic mutants.
        (Sekelsky et al., 1999)
        hide External Crossreferences & Linkouts
        Sequence Crossreferences
        RefSeq (Transcripts)
        •
        RefSeq (Proteins)
        •
        DDBJ / EMBL / GenBank
        •
        UniProtKB/TrEMBL
        •
        Other Crossreferences
        InterPro domains - A database of protein families, domains, and functional sites
        •
        Zinc finger, B-box (IPR000315)
        NHL repeat (IPR001258)
        Zinc finger, RING-type (IPR001841)
        B-box, C-terminal (IPR003649)
        NHL repeat, subgroup (IPR013017)
        Six-bladed beta-propeller, TolB-like (IPR011042)
        Linkouts
        BDGP expression data
        •
        Show all BDGP original images, annotations and embryonic microarray data for mei-P26
        BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions
        •
        DEDB - Drosophila exon database: splicing graphs
        •
        DRSC - RNAi screening (Harvard): high-throughput cell culture data and design
        •
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        •
        FlyExpress - Embryonic expression images (BDGP data)
        •
        FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans
        •
        GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies
        •
        GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data
        •
        InParanoid orthologs - Eukaryotic orthologs
        •
        PANTHER - Protein classification by function, families, and pathways
        •
        hide Synonyms & Secondary IDs ( 6 )
        Reported As
        Symbol Synonym
        AF145661
        (Arama et al., 2000)
        BcDNA:GH10646
        (Boutros et al., 2004, )
        CG12218
        (Page, 2001.4.4, Mack et al., 2006)
        mei-P26
        (Mukai et al., 2006, Nurminsky, 2007)
        Mei-P26
        (Neumueller et al., 2007)
        MEI-P26
        (O'Farrell et al., 2008)
        Name Synonym
        mei-P26
         
        Secondary FlyBase IDs
        • FBgn0027551
        hide References ( 31 )
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        List References by type
        hide Recent research papers ( 3 )
        O'Farrell et al., 2008, Dev. Dynamics 237(1): 196--208
        Regulation of the Drosophila lin-41 homologue dappled by let-7 reveals conservation of a regulatory mechanism within the LIN-41 subclade. [FBrf0201979]
        Mack et al., 2006, Proc. Natl. Acad. Sci. USA 103(27): 10358--10363
        Mating-responsive genes in reproductive tissues of female Drosophila melanogaster. [FBrf0194111]
        Mukai et al., 2006, Gene Expression Patterns 6(3): 256--266
        Expression of meiotic genes in the germline progenitors of Drosophila embryos. [FBrf0190509]
        Show all research papers ...
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        All reviews listed in FlyBase were published before 2006
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