General Information Symbol Dmel\ gukhSpecies D. melanogaster Name GUK-holder Annotation symbol CG31043 Feature type protein_coding_gene FlyBase ID FBgn0026239 Gene Model Status Current Stock availability 11 publicly
available Genomic Location Chromosome (arm) 3R Recombination map Cytogenetic map 91E2-91E3 Sequence location 3R:14,809,747..14,848,160 [+]
Genomic Maps
Summary Information Automatically generated summary
See sections below for more information The gene
GUK-holder is referred to in FlyBase by the symbol
Dmel\gukh (CG31043, FBgn0026239). It is a protein_coding_gene from
Drosophila melanogaster . There is experimental evidence that it has the
molecular function : protein binding. There is experimental evidence that it is involved in the
biological process : protein localization; axon guidance.
25 alleles are reported . No phenotypic data is available. It has
4 annotated transcripts and
4 annotated polypeptides . Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the pupal period. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval/adult Malpighian tubules, larval fat body, adult female reproductive system, adult testis. Comments on Affy2 ProbeSet: ProbeSet 1635427_a_at completely aligns to an exonic region common to each of the 4 FlyBase-annotated transcript isoforms of gukh. Gene sequence location is
3R:14809747..14848160 .
User Contributed Data External Summaries
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FB2013_03
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Detailed Mapping Data
FlyBase Computed Cytological Location
Experimentally Determined Cytological Location
81-100
(determined by in situ hybridisation)
Experimentally Determined Recombination Data
Location Left of (cM) Right of (cM) Notes Gene Model & Products Comments on Gene
Model Transcript Data Annotated Transcripts Additional Transcript Data
& Comments Reported size (kB) Comments External Data Crossreferences
Polypeptide Data Annotated
Polypeptides Additional Polypeptide
Data & Comments Reported size (kDa) Comments External Data Linkouts Crossreferences Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank UniProtKB/Swiss-Prot UniProtKB/TrEMBL Mapped Features Mapped Features have been reorganized, please
see this article for details. Additional mapped features and mutations can
be found on GBrowse or related reports. External Data Linkouts Crossreferences Expression Data Transcript ExpressionComment: maternally deposited
Comment: anlage in statu nascendi
Comment: reported as procephalic ectoderm anlage in statu nascendi
Comment: reported as procephalic ectoderm anlage in statu nascendi
Comment: reported as procephalic ectoderm anlage in statu nascendi
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Additional Descriptive Data
Marker for Subcellular Localization CV Term Polypeptide Expression
Additional Descriptive Data
Marker for Subcellular Localization (GO Cellular Component) inferred from direct assay
inferred from direct assay
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference
FlyAtlas Anatomy Microarray
Linear, scaled to maximum expression level
Tissue
Expression Level
Larval Central Nervous System
347.8
Larval Midgut
76.2
Larval Hindgut
92.1
Larval Malpighian Tubules
149.7
Larval Fat Body
139.2
Larval Salivary Gland
80.9
Larval Trachea
61.35
Larval Carcass
46.6
Adult Head
64.5
Adult Eye
70.05
Adult Brain
94.7
Adult Thoracic-Abdominal Ganglion
88.7
Adult Crop
52.5
Adult Midgut
91.7
Adult Hindgut
83.4
Adult Malpighian Tubules
157.5
Adult Fat Body
48.7
Adult Salivary Gland
21.9
Adult Heart
40.3
Adult VirginFemale Spermatheca
104.1
Adult InseminatedFemale Spermatheca
130.5
Adult Ovary
156.6
Adult Testis
112.5
Adult Male Accessory Gland
77.3
Adult Carcass
72.4
Expression Level Scale
None
Low
Moderate
Linear, scaled to Moderate expression
Tissue
Expression Level
Larval Central Nervous System
347.8
Larval Midgut
76.2
Larval Hindgut
92.1
Larval Malpighian Tubules
149.7
Larval Fat Body
139.2
Larval Salivary Gland
80.9
Larval Trachea
61.35
Larval Carcass
46.6
Adult Head
64.5
Adult Eye
70.05
Adult Brain
94.7
Adult Thoracic-Abdominal Ganglion
88.7
Adult Crop
52.5
Adult Midgut
91.7
Adult Hindgut
83.4
Adult Malpighian Tubules
157.5
Adult Fat Body
48.7
Adult Salivary Gland
21.9
Adult Heart
40.3
Adult VirginFemale Spermatheca
104.1
Adult InseminatedFemale Spermatheca
130.5
Adult Ovary
156.6
Adult Testis
112.5
Adult Male Accessory Gland
77.3
Adult Carcass
72.4
Expression Level Scale
None
Low
Moderate
High
Linear, scaled to High level expression
Tissue
Expression Level
Larval Central Nervous System
347.8
Larval Midgut
76.2
Larval Hindgut
92.1
Larval Malpighian Tubules
149.7
Larval Fat Body
139.2
Larval Salivary Gland
80.9
Larval Trachea
61.35
Larval Carcass
46.6
Adult Head
64.5
Adult Eye
70.05
Adult Brain
94.7
Adult Thoracic-Abdominal Ganglion
88.7
Adult Crop
52.5
Adult Midgut
91.7
Adult Hindgut
83.4
Adult Malpighian Tubules
157.5
Adult Fat Body
48.7
Adult Salivary Gland
21.9
Adult Heart
40.3
Adult VirginFemale Spermatheca
104.1
Adult InseminatedFemale Spermatheca
130.5
Adult Ovary
156.6
Adult Testis
112.5
Adult Male Accessory Gland
77.3
Adult Carcass
72.4
Expression Level Scale
None
Low
Moderate
High
Very high
Linear, scaled to Very high expression
Tissue
Expression Level
Larval Central Nervous System
347.8
Larval Midgut
76.2
Larval Hindgut
92.1
Larval Malpighian Tubules
149.7
Larval Fat Body
139.2
Larval Salivary Gland
80.9
Larval Trachea
61.35
Larval Carcass
46.6
Adult Head
64.5
Adult Eye
70.05
Adult Brain
94.7
Adult Thoracic-Abdominal Ganglion
88.7
Adult Crop
52.5
Adult Midgut
91.7
Adult Hindgut
83.4
Adult Malpighian Tubules
157.5
Adult Fat Body
48.7
Adult Salivary Gland
21.9
Adult Heart
40.3
Adult VirginFemale Spermatheca
104.1
Adult InseminatedFemale Spermatheca
130.5
Adult Ovary
156.6
Adult Testis
112.5
Adult Male Accessory Gland
77.3
Adult Carcass
72.4
Expression Level Scale
Very high
log, scaled to maximum expression level
Tissue
Expression Level
Larval Central Nervous System
347.8
Larval Midgut
76.2
Larval Hindgut
92.1
Larval Malpighian Tubules
149.7
Larval Fat Body
139.2
Larval Salivary Gland
80.9
Larval Trachea
61.35
Larval Carcass
46.6
Adult Head
64.5
Adult Eye
70.05
Adult Brain
94.7
Adult Thoracic-Abdominal Ganglion
88.7
Adult Crop
52.5
Adult Midgut
91.7
Adult Hindgut
83.4
Adult Malpighian Tubules
157.5
Adult Fat Body
48.7
Adult Salivary Gland
21.9
Adult Heart
40.3
Adult VirginFemale Spermatheca
104.1
Adult InseminatedFemale Spermatheca
130.5
Adult Ovary
156.6
Adult Testis
112.5
Adult Male Accessory Gland
77.3
Adult Carcass
72.4
Expression Level Scale
None
Low
Moderate
High
log, scaled to Moderate expression
Tissue
Expression Level
Larval Central Nervous System
347.8
Larval Midgut
76.2
Larval Hindgut
92.1
Larval Malpighian Tubules
149.7
Larval Fat Body
139.2
Larval Salivary Gland
80.9
Larval Trachea
61.35
Larval Carcass
46.6
Adult Head
64.5
Adult Eye
70.05
Adult Brain
94.7
Adult Thoracic-Abdominal Ganglion
88.7
Adult Crop
52.5
Adult Midgut
91.7
Adult Hindgut
83.4
Adult Malpighian Tubules
157.5
Adult Fat Body
48.7
Adult Salivary Gland
21.9
Adult Heart
40.3
Adult VirginFemale Spermatheca
104.1
Adult InseminatedFemale Spermatheca
130.5
Adult Ovary
156.6
Adult Testis
112.5
Adult Male Accessory Gland
77.3
Adult Carcass
72.4
Expression Level Scale
None
Low
Moderate
High
log, scaled to High level expression
Tissue
Expression Level
Larval Central Nervous System
347.8
Larval Midgut
76.2
Larval Hindgut
92.1
Larval Malpighian Tubules
149.7
Larval Fat Body
139.2
Larval Salivary Gland
80.9
Larval Trachea
61.35
Larval Carcass
46.6
Adult Head
64.5
Adult Eye
70.05
Adult Brain
94.7
Adult Thoracic-Abdominal Ganglion
88.7
Adult Crop
52.5
Adult Midgut
91.7
Adult Hindgut
83.4
Adult Malpighian Tubules
157.5
Adult Fat Body
48.7
Adult Salivary Gland
21.9
Adult Heart
40.3
Adult VirginFemale Spermatheca
104.1
Adult InseminatedFemale Spermatheca
130.5
Adult Ovary
156.6
Adult Testis
112.5
Adult Male Accessory Gland
77.3
Adult Carcass
72.4
Expression Level Scale
None
Low
Moderate
High
Very high
log, scaled to Very high expression
Tissue
Expression Level
Larval Central Nervous System
347.8
Larval Midgut
76.2
Larval Hindgut
92.1
Larval Malpighian Tubules
149.7
Larval Fat Body
139.2
Larval Salivary Gland
80.9
Larval Trachea
61.35
Larval Carcass
46.6
Adult Head
64.5
Adult Eye
70.05
Adult Brain
94.7
Adult Thoracic-Abdominal Ganglion
88.7
Adult Crop
52.5
Adult Midgut
91.7
Adult Hindgut
83.4
Adult Malpighian Tubules
157.5
Adult Fat Body
48.7
Adult Salivary Gland
21.9
Adult Heart
40.3
Adult VirginFemale Spermatheca
104.1
Adult InseminatedFemale Spermatheca
130.5
Adult Ovary
156.6
Adult Testis
112.5
Adult Male Accessory Gland
77.3
Adult Carcass
72.4
Expression Level Scale
None
Low
Moderate
High
Very high
Heatmap
Tissue
Expression Level
Larval Central Nervous System
Larval Midgut
Larval Hindgut
Larval Malpighian Tubules
Larval Fat Body
Larval Salivary Gland
Larval Trachea
Larval Carcass
Adult Head
Adult Eye
Adult Brain
Adult Thoracic-Abdominal Ganglion
Adult Crop
Adult Midgut
Adult Hindgut
Adult Malpighian Tubules
Adult Fat Body
Adult Salivary Gland
Adult Heart
Adult VirginFemale Spermatheca
Adult InseminatedFemale Spermatheca
Adult Ovary
Adult Testis
Adult Male Accessory Gland
Adult Carcass
FlyAtlas Organ/Tissue Expression, larval vs. adult
Larval Expression Level
Tissue
Adult Expression Level
NA
Head
64.5
NA
Eye
70.05
NA
Brain
94.7
347.8
Central Nervous System
NA
NA
Thoracic-Abdominal Ganglion
88.7
NA
Crop
52.5
76.2
Midgut
91.7
92.1
Hindgut
83.4
149.7
Malpighian Tubules
157.5
139.2
Fat Body
48.7
80.9
Salivary Gland
no informative data
NA
Heart
40.3
61.35
Trachea
NA
NA
VirginFemale Spermatheca
104.1
NA
InseminatedFemale Spermatheca
130.5
NA
Ovary
156.6
NA
Testis
112.5
NA
Male Accessory Gland
77.3
46.6
Carcass
72.4
modENCODE Anatomy RNA-Seq
Linear, scaled to maximum expression level
Tissue
Expression Level
imaginal disc, larvae L3 wandering
37
central nervous system, larvae L3
23
central nervous system, pupae P8
15
head, virgin 1-day female
3
head, virgin 4-day female
4
head, virgin 20-day female
3
head, mated 1-day female
4
head, mated 4-day female
3
head, mated 20-day female
4
head, mated 1-day male
6
head, mated 4-day male
4
head, mated 20-day male
3
salivary gland, larvae L3 wandering
1
salivary gland, white prepupae
13
digestive system, larvae L3 wandering
5
digestive system, 1-day adult
5
digestive system, 4-day adult
5
digestive system, 20-day adult
6
fat body, larvae L3 wandering
7
fat body, white prepupae
9
fat body, pupae P8
10
carcass, larvae L3 wandering
16
carcass, 1-day adult
6
carcass, 4-day adult
6
carcass, 20-day adult
5
ovary, virgin 4-day female
13
ovary, mated 4-day female
12
testis, mated 4-day male
18
accessory gland, mated 4-day male
5
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to Moderate expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
(37)
central nervous system, larvae L3
23
central nervous system, pupae P8
15
head, virgin 1-day female
3
head, virgin 4-day female
4
head, virgin 20-day female
3
head, mated 1-day female
4
head, mated 4-day female
3
head, mated 20-day female
4
head, mated 1-day male
6
head, mated 4-day male
4
head, mated 20-day male
3
salivary gland, larvae L3 wandering
1
salivary gland, white prepupae
13
digestive system, larvae L3 wandering
5
digestive system, 1-day adult
5
digestive system, 4-day adult
5
digestive system, 20-day adult
6
fat body, larvae L3 wandering
7
fat body, white prepupae
9
fat body, pupae P8
10
carcass, larvae L3 wandering
16
carcass, 1-day adult
6
carcass, 4-day adult
6
carcass, 20-day adult
5
ovary, virgin 4-day female
13
ovary, mated 4-day female
12
testis, mated 4-day male
18
accessory gland, mated 4-day male
5
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to High expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
37
central nervous system, larvae L3
23
central nervous system, pupae P8
15
head, virgin 1-day female
3
head, virgin 4-day female
4
head, virgin 20-day female
3
head, mated 1-day female
4
head, mated 4-day female
3
head, mated 20-day female
4
head, mated 1-day male
6
head, mated 4-day male
4
head, mated 20-day male
3
salivary gland, larvae L3 wandering
1
salivary gland, white prepupae
13
digestive system, larvae L3 wandering
5
digestive system, 1-day adult
5
digestive system, 4-day adult
5
digestive system, 20-day adult
6
fat body, larvae L3 wandering
7
fat body, white prepupae
9
fat body, pupae P8
10
carcass, larvae L3 wandering
16
carcass, 1-day adult
6
carcass, 4-day adult
6
carcass, 20-day adult
5
ovary, virgin 4-day female
13
ovary, mated 4-day female
12
testis, mated 4-day male
18
accessory gland, mated 4-day male
5
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Extremely high expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
37
central nervous system, larvae L3
23
central nervous system, pupae P8
15
head, virgin 1-day female
3
head, virgin 4-day female
4
head, virgin 20-day female
3
head, mated 1-day female
4
head, mated 4-day female
3
head, mated 20-day female
4
head, mated 1-day male
6
head, mated 4-day male
4
head, mated 20-day male
3
salivary gland, larvae L3 wandering
1
salivary gland, white prepupae
13
digestive system, larvae L3 wandering
5
digestive system, 1-day adult
5
digestive system, 4-day adult
5
digestive system, 20-day adult
6
fat body, larvae L3 wandering
7
fat body, white prepupae
9
fat body, pupae P8
10
carcass, larvae L3 wandering
16
carcass, 1-day adult
6
carcass, 4-day adult
6
carcass, 20-day adult
5
ovary, virgin 4-day female
13
ovary, mated 4-day female
12
testis, mated 4-day male
18
accessory gland, mated 4-day male
5
Expression Level Scale
Extremely high
log, scaled to maximum expression level
Tissue
Expression Level
imaginal disc, larvae L3 wandering
37
central nervous system, larvae L3
23
central nervous system, pupae P8
15
head, virgin 1-day female
3
head, virgin 4-day female
4
head, virgin 20-day female
3
head, mated 1-day female
4
head, mated 4-day female
3
head, mated 20-day female
4
head, mated 1-day male
6
head, mated 4-day male
4
head, mated 20-day male
3
salivary gland, larvae L3 wandering
1
salivary gland, white prepupae
13
digestive system, larvae L3 wandering
5
digestive system, 1-day adult
5
digestive system, 4-day adult
5
digestive system, 20-day adult
6
fat body, larvae L3 wandering
7
fat body, white prepupae
9
fat body, pupae P8
10
carcass, larvae L3 wandering
16
carcass, 1-day adult
6
carcass, 4-day adult
6
carcass, 20-day adult
5
ovary, virgin 4-day female
13
ovary, mated 4-day female
12
testis, mated 4-day male
18
accessory gland, mated 4-day male
5
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
log, scaled to Moderate expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
(37)
central nervous system, larvae L3
23
central nervous system, pupae P8
15
head, virgin 1-day female
3
head, virgin 4-day female
4
head, virgin 20-day female
3
head, mated 1-day female
4
head, mated 4-day female
3
head, mated 20-day female
4
head, mated 1-day male
6
head, mated 4-day male
4
head, mated 20-day male
3
salivary gland, larvae L3 wandering
1
salivary gland, white prepupae
13
digestive system, larvae L3 wandering
5
digestive system, 1-day adult
5
digestive system, 4-day adult
5
digestive system, 20-day adult
6
fat body, larvae L3 wandering
7
fat body, white prepupae
9
fat body, pupae P8
10
carcass, larvae L3 wandering
16
carcass, 1-day adult
6
carcass, 4-day adult
6
carcass, 20-day adult
5
ovary, virgin 4-day female
13
ovary, mated 4-day female
12
testis, mated 4-day male
18
accessory gland, mated 4-day male
5
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to High expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
37
central nervous system, larvae L3
23
central nervous system, pupae P8
15
head, virgin 1-day female
3
head, virgin 4-day female
4
head, virgin 20-day female
3
head, mated 1-day female
4
head, mated 4-day female
3
head, mated 20-day female
4
head, mated 1-day male
6
head, mated 4-day male
4
head, mated 20-day male
3
salivary gland, larvae L3 wandering
1
salivary gland, white prepupae
13
digestive system, larvae L3 wandering
5
digestive system, 1-day adult
5
digestive system, 4-day adult
5
digestive system, 20-day adult
6
fat body, larvae L3 wandering
7
fat body, white prepupae
9
fat body, pupae P8
10
carcass, larvae L3 wandering
16
carcass, 1-day adult
6
carcass, 4-day adult
6
carcass, 20-day adult
5
ovary, virgin 4-day female
13
ovary, mated 4-day female
12
testis, mated 4-day male
18
accessory gland, mated 4-day male
5
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Extremely high expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
37
central nervous system, larvae L3
23
central nervous system, pupae P8
15
head, virgin 1-day female
3
head, virgin 4-day female
4
head, virgin 20-day female
3
head, mated 1-day female
4
head, mated 4-day female
3
head, mated 20-day female
4
head, mated 1-day male
6
head, mated 4-day male
4
head, mated 20-day male
3
salivary gland, larvae L3 wandering
1
salivary gland, white prepupae
13
digestive system, larvae L3 wandering
5
digestive system, 1-day adult
5
digestive system, 4-day adult
5
digestive system, 20-day adult
6
fat body, larvae L3 wandering
7
fat body, white prepupae
9
fat body, pupae P8
10
carcass, larvae L3 wandering
16
carcass, 1-day adult
6
carcass, 4-day adult
6
carcass, 20-day adult
5
ovary, virgin 4-day female
13
ovary, mated 4-day female
12
testis, mated 4-day male
18
accessory gland, mated 4-day male
5
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Heatmap
Tissue
Expression Level
imaginal disc, larvae L3 wandering
central nervous system, larvae L3
central nervous system, pupae P8
head, virgin 1-day female
head, virgin 4-day female
head, virgin 20-day female
head, mated 1-day female
head, mated 4-day female
head, mated 20-day female
head, mated 1-day male
head, mated 4-day male
head, mated 20-day male
salivary gland, larvae L3 wandering
salivary gland, white prepupae
digestive system, larvae L3 wandering
digestive system, 1-day adult
digestive system, 4-day adult
digestive system, 20-day adult
fat body, larvae L3 wandering
fat body, white prepupae
fat body, pupae P8
carcass, larvae L3 wandering
carcass, 1-day adult
carcass, 4-day adult
carcass, 20-day adult
ovary, virgin 4-day female
ovary, mated 4-day female
testis, mated 4-day male
accessory gland, mated 4-day male
modENCODE Development RNA-Seq
Linear, scaled to maximum expression level
Developmental Stage
Expression Level
embryo 00-02hr
16
embryo 02-04hr
15
embryo 04-06hr
32
embryo 06-08hr
45
embryo 08-10hr
43
embryo 10-12hr
48
embryo 12-14hr
39
embryo 14-16hr
35
embryo 16-18hr
24
embryo 18-20hr
22
embryo 20-22hr
12
embryo 22-24hr
10
larva L1
10
larva L2
6
larva L3 12hr old
4
larva L3 puffstage 1-2
6
larva L3 puffstage 3-6
13
larva L3 puffstage 7-9
16
white prepupae new
18
white prepupae 12hr
22
white prepupae 24hr
33
pupae 2d postWPP
19
pupae 3d postWPP
13
pupae 4d postWPP
10
adult male 01day
9
adult male 05day
11
adult male 30day
10
adult female 01day
11
adult female 05day
10
adult female 30day
11
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Linear, scaled to Moderate expression
Developmental Stage
Expression Level
embryo 00-02hr
16
embryo 02-04hr
15
embryo 04-06hr
(32)
embryo 06-08hr
(45)
embryo 08-10hr
(43)
embryo 10-12hr
(48)
embryo 12-14hr
(39)
embryo 14-16hr
(35)
embryo 16-18hr
24
embryo 18-20hr
22
embryo 20-22hr
12
embryo 22-24hr
10
larva L1
10
larva L2
6
larva L3 12hr old
4
larva L3 puffstage 1-2
6
larva L3 puffstage 3-6
13
larva L3 puffstage 7-9
16
white prepupae new
18
white prepupae 12hr
22
white prepupae 24hr
(33)
pupae 2d postWPP
19
pupae 3d postWPP
13
pupae 4d postWPP
10
adult male 01day
9
adult male 05day
11
adult male 30day
10
adult female 01day
11
adult female 05day
10
adult female 30day
11
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to High expression
Developmental Stage
Expression Level
embryo 00-02hr
16
embryo 02-04hr
15
embryo 04-06hr
32
embryo 06-08hr
45
embryo 08-10hr
43
embryo 10-12hr
48
embryo 12-14hr
39
embryo 14-16hr
35
embryo 16-18hr
24
embryo 18-20hr
22
embryo 20-22hr
12
embryo 22-24hr
10
larva L1
10
larva L2
6
larva L3 12hr old
4
larva L3 puffstage 1-2
6
larva L3 puffstage 3-6
13
larva L3 puffstage 7-9
16
white prepupae new
18
white prepupae 12hr
22
white prepupae 24hr
33
pupae 2d postWPP
19
pupae 3d postWPP
13
pupae 4d postWPP
10
adult male 01day
9
adult male 05day
11
adult male 30day
10
adult female 01day
11
adult female 05day
10
adult female 30day
11
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Extremely high expression
Developmental Stage
Expression Level
embryo 00-02hr
16
embryo 02-04hr
15
embryo 04-06hr
32
embryo 06-08hr
45
embryo 08-10hr
43
embryo 10-12hr
48
embryo 12-14hr
39
embryo 14-16hr
35
embryo 16-18hr
24
embryo 18-20hr
22
embryo 20-22hr
12
embryo 22-24hr
10
larva L1
10
larva L2
6
larva L3 12hr old
4
larva L3 puffstage 1-2
6
larva L3 puffstage 3-6
13
larva L3 puffstage 7-9
16
white prepupae new
18
white prepupae 12hr
22
white prepupae 24hr
33
pupae 2d postWPP
19
pupae 3d postWPP
13
pupae 4d postWPP
10
adult male 01day
9
adult male 05day
11
adult male 30day
10
adult female 01day
11
adult female 05day
10
adult female 30day
11
Expression Level Scale
Extremely high
log, scaled to maximum expression level
Developmental Stage
Expression Level
embryo 00-02hr
16
embryo 02-04hr
15
embryo 04-06hr
32
embryo 06-08hr
45
embryo 08-10hr
43
embryo 10-12hr
48
embryo 12-14hr
39
embryo 14-16hr
35
embryo 16-18hr
24
embryo 18-20hr
22
embryo 20-22hr
12
embryo 22-24hr
10
larva L1
10
larva L2
6
larva L3 12hr old
4
larva L3 puffstage 1-2
6
larva L3 puffstage 3-6
13
larva L3 puffstage 7-9
16
white prepupae new
18
white prepupae 12hr
22
white prepupae 24hr
33
pupae 2d postWPP
19
pupae 3d postWPP
13
pupae 4d postWPP
10
adult male 01day
9
adult male 05day
11
adult male 30day
10
adult female 01day
11
adult female 05day
10
adult female 30day
11
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
log, scaled to Moderate expression
Developmental Stage
Expression Level
embryo 00-02hr
16
embryo 02-04hr
15
embryo 04-06hr
32
embryo 06-08hr
(45)
embryo 08-10hr
(43)
embryo 10-12hr
(48)
embryo 12-14hr
(39)
embryo 14-16hr
(35)
embryo 16-18hr
24
embryo 18-20hr
22
embryo 20-22hr
12
embryo 22-24hr
10
larva L1
10
larva L2
6
larva L3 12hr old
4
larva L3 puffstage 1-2
6
larva L3 puffstage 3-6
13
larva L3 puffstage 7-9
16
white prepupae new
18
white prepupae 12hr
22
white prepupae 24hr
(33)
pupae 2d postWPP
19
pupae 3d postWPP
13
pupae 4d postWPP
10
adult male 01day
9
adult male 05day
11
adult male 30day
10
adult female 01day
11
adult female 05day
10
adult female 30day
11
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to High expression
Developmental Stage
Expression Level
embryo 00-02hr
16
embryo 02-04hr
15
embryo 04-06hr
32
embryo 06-08hr
45
embryo 08-10hr
43
embryo 10-12hr
48
embryo 12-14hr
39
embryo 14-16hr
35
embryo 16-18hr
24
embryo 18-20hr
22
embryo 20-22hr
12
embryo 22-24hr
10
larva L1
10
larva L2
6
larva L3 12hr old
4
larva L3 puffstage 1-2
6
larva L3 puffstage 3-6
13
larva L3 puffstage 7-9
16
white prepupae new
18
white prepupae 12hr
22
white prepupae 24hr
33
pupae 2d postWPP
19
pupae 3d postWPP
13
pupae 4d postWPP
10
adult male 01day
9
adult male 05day
11
adult male 30day
10
adult female 01day
11
adult female 05day
10
adult female 30day
11
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Extremely high expression
Developmental Stage
Expression Level
embryo 00-02hr
16
embryo 02-04hr
15
embryo 04-06hr
32
embryo 06-08hr
45
embryo 08-10hr
43
embryo 10-12hr
48
embryo 12-14hr
39
embryo 14-16hr
35
embryo 16-18hr
24
embryo 18-20hr
22
embryo 20-22hr
12
embryo 22-24hr
10
larva L1
10
larva L2
6
larva L3 12hr old
4
larva L3 puffstage 1-2
6
larva L3 puffstage 3-6
13
larva L3 puffstage 7-9
16
white prepupae new
18
white prepupae 12hr
22
white prepupae 24hr
33
pupae 2d postWPP
19
pupae 3d postWPP
13
pupae 4d postWPP
10
adult male 01day
9
adult male 05day
11
adult male 30day
10
adult female 01day
11
adult female 05day
10
adult female 30day
11
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Heatmap
Developmental Stage
Expression Level
embryo 00-02hr
embryo 02-04hr
embryo 04-06hr
embryo 06-08hr
embryo 08-10hr
embryo 10-12hr
embryo 12-14hr
embryo 14-16hr
embryo 16-18hr
embryo 18-20hr
embryo 20-22hr
embryo 22-24hr
larva L1
larva L2
larva L3 12hr old
larva L3 puffstage 1-2
larva L3 puffstage 3-6
larva L3 puffstage 7-9
white prepupae new
white prepupae 12hr
white prepupae 24hr
pupae 2d postWPP
pupae 3d postWPP
pupae 4d postWPP
adult male 01day
adult male 05day
adult male 30day
adult female 01day
adult female 05day
adult female 30day
modENCODE Cell Lines RNA-Seq
Linear, scaled to maximum expression level
Cell Line
Expression Level
Schneider line 2 S2R+
1
Schneider line 2 Sg4
1
embryonic 1182-4H
0
embryonic GM2
1
embryonic Kc167
1
embryonic S1
6
embryonic S3
5
leg disc CME L1
1
wing disc CME-W2
1
wing disc ML-DmD8
0
wing disc ML-DmD9
0
wing disc ML-DmD16-c3
2
wing disc ML-DmD21
1
wing disc ML-DmD32
1
haltere disc ML-DmD17-c3
3
eye-antennal disc ML-DmD11
0
antennal disc ML-DmD20-c5
0
mixed discs ML-DmD4-c1
1
CNS ML-DmBG1-c1
0
CNS ML-DmBG2-c2
1
tumorous blood cells mbn2
0
ovary fGS/OSS
25
ovary OSC
10
ovary OSS
17
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to Moderate expression
Cell Line
Expression Level
Schneider line 2 S2R+
1
Schneider line 2 Sg4
1
embryonic 1182-4H
0
embryonic GM2
1
embryonic Kc167
1
embryonic S1
6
embryonic S3
5
leg disc CME L1
1
wing disc CME-W2
1
wing disc ML-DmD8
0
wing disc ML-DmD9
0
wing disc ML-DmD16-c3
2
wing disc ML-DmD21
1
wing disc ML-DmD32
1
haltere disc ML-DmD17-c3
3
eye-antennal disc ML-DmD11
0
antennal disc ML-DmD20-c5
0
mixed discs ML-DmD4-c1
1
CNS ML-DmBG1-c1
0
CNS ML-DmBG2-c2
1
tumorous blood cells mbn2
0
ovary fGS/OSS
25
ovary OSC
10
ovary OSS
17
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to High expression
Cell Line
Expression Level
Schneider line 2 S2R+
1
Schneider line 2 Sg4
1
embryonic 1182-4H
0
embryonic GM2
1
embryonic Kc167
1
embryonic S1
6
embryonic S3
5
leg disc CME L1
1
wing disc CME-W2
1
wing disc ML-DmD8
0
wing disc ML-DmD9
0
wing disc ML-DmD16-c3
2
wing disc ML-DmD21
1
wing disc ML-DmD32
1
haltere disc ML-DmD17-c3
3
eye-antennal disc ML-DmD11
0
antennal disc ML-DmD20-c5
0
mixed discs ML-DmD4-c1
1
CNS ML-DmBG1-c1
0
CNS ML-DmBG2-c2
1
tumorous blood cells mbn2
0
ovary fGS/OSS
25
ovary OSC
10
ovary OSS
17
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Extremely high expression
Cell Line
Expression Level
Schneider line 2 S2R+
1
Schneider line 2 Sg4
1
embryonic 1182-4H
0
embryonic GM2
1
embryonic Kc167
1
embryonic S1
6
embryonic S3
5
leg disc CME L1
1
wing disc CME-W2
1
wing disc ML-DmD8
0
wing disc ML-DmD9
0
wing disc ML-DmD16-c3
2
wing disc ML-DmD21
1
wing disc ML-DmD32
1
haltere disc ML-DmD17-c3
3
eye-antennal disc ML-DmD11
0
antennal disc ML-DmD20-c5
0
mixed discs ML-DmD4-c1
1
CNS ML-DmBG1-c1
0
CNS ML-DmBG2-c2
1
tumorous blood cells mbn2
0
ovary fGS/OSS
25
ovary OSC
10
ovary OSS
17
Expression Level Scale
Extremely high
log, scaled to maximum expression level
Cell Line
Expression Level
Schneider line 2 S2R+
1
Schneider line 2 Sg4
1
embryonic 1182-4H
0
embryonic GM2
1
embryonic Kc167
1
embryonic S1
6
embryonic S3
5
leg disc CME L1
1
wing disc CME-W2
1
wing disc ML-DmD8
0
wing disc ML-DmD9
0
wing disc ML-DmD16-c3
2
wing disc ML-DmD21
1
wing disc ML-DmD32
1
haltere disc ML-DmD17-c3
3
eye-antennal disc ML-DmD11
0
antennal disc ML-DmD20-c5
0
mixed discs ML-DmD4-c1
1
CNS ML-DmBG1-c1
0
CNS ML-DmBG2-c2
1
tumorous blood cells mbn2
0
ovary fGS/OSS
25
ovary OSC
10
ovary OSS
17
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to Moderate expression
Cell Line
Expression Level
Schneider line 2 S2R+
1
Schneider line 2 Sg4
1
embryonic 1182-4H
0
embryonic GM2
1
embryonic Kc167
1
embryonic S1
6
embryonic S3
5
leg disc CME L1
1
wing disc CME-W2
1
wing disc ML-DmD8
0
wing disc ML-DmD9
0
wing disc ML-DmD16-c3
2
wing disc ML-DmD21
1
wing disc ML-DmD32
1
haltere disc ML-DmD17-c3
3
eye-antennal disc ML-DmD11
0
antennal disc ML-DmD20-c5
0
mixed discs ML-DmD4-c1
1
CNS ML-DmBG1-c1
0
CNS ML-DmBG2-c2
1
tumorous blood cells mbn2
0
ovary fGS/OSS
25
ovary OSC
10
ovary OSS
17
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to High expression
Cell Line
Expression Level
Schneider line 2 S2R+
1
Schneider line 2 Sg4
1
embryonic 1182-4H
0
embryonic GM2
1
embryonic Kc167
1
embryonic S1
6
embryonic S3
5
leg disc CME L1
1
wing disc CME-W2
1
wing disc ML-DmD8
0
wing disc ML-DmD9
0
wing disc ML-DmD16-c3
2
wing disc ML-DmD21
1
wing disc ML-DmD32
1
haltere disc ML-DmD17-c3
3
eye-antennal disc ML-DmD11
0
antennal disc ML-DmD20-c5
0
mixed discs ML-DmD4-c1
1
CNS ML-DmBG1-c1
0
CNS ML-DmBG2-c2
1
tumorous blood cells mbn2
0
ovary fGS/OSS
25
ovary OSC
10
ovary OSS
17
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Extremely high expression
Cell Line
Expression Level
Schneider line 2 S2R+
1
Schneider line 2 Sg4
1
embryonic 1182-4H
0
embryonic GM2
1
embryonic Kc167
1
embryonic S1
6
embryonic S3
5
leg disc CME L1
1
wing disc CME-W2
1
wing disc ML-DmD8
0
wing disc ML-DmD9
0
wing disc ML-DmD16-c3
2
wing disc ML-DmD21
1
wing disc ML-DmD32
1
haltere disc ML-DmD17-c3
3
eye-antennal disc ML-DmD11
0
antennal disc ML-DmD20-c5
0
mixed discs ML-DmD4-c1
1
CNS ML-DmBG1-c1
0
CNS ML-DmBG2-c2
1
tumorous blood cells mbn2
0
ovary fGS/OSS
25
ovary OSC
10
ovary OSS
17
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Heatmap
Cell Line
Expression Level
Schneider line 2 S2R+
Schneider line 2 Sg4
embryonic 1182-4H
embryonic GM2
embryonic Kc167
embryonic S1
embryonic S3
leg disc CME L1
wing disc CME-W2
wing disc ML-DmD8
wing disc ML-DmD9
wing disc ML-DmD16-c3
wing disc ML-DmD21
wing disc ML-DmD32
haltere disc ML-DmD17-c3
eye-antennal disc ML-DmD11
antennal disc ML-DmD20-c5
mixed discs ML-DmD4-c1
CNS ML-DmBG1-c1
CNS ML-DmBG2-c2
tumorous blood cells mbn2
ovary fGS/OSS
ovary OSC
ovary OSS
modENCODE Treatments RNA-Seq
Linear, scaled to maximum expression level
Treatment
Expression Level
extended cold, 4-day adult
9
cold shock, 4-day adult
7
heat shock, 4-day adult
7
Cadmium 50 mM 6 hrs, larvae L3
2
Cadmium 50 mM 12 hrs, larvae L3
3
Cadmium 50 mM 48 hrs, 4-day adult
6
Cadmium 100 mM 48 hrs, 4-day adult
11
Copper 0.5 mM 12 hrs, larvae L3
4
Copper 15 mM 48 hrs, 4-day adult
4
Zinc 5 mM 12 hrs, larvae L3
4
Zinc 4.5 mM 48 hrs, 4-day adult
6
Ethanol 2.5% 3 hrs, larvae L3
14
Ethanol 5% 3 hrs, larvae L3
2
Ethanol 10% 3 hrs, larvae L3
2
Caffeine 1.5 mg/ml 4 hrs, larvae L3
2
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
12
Caffeine 25 mg/ml 48 hrs, 4-day adult
8
Paraquat 5 mM 48 hrs, 4-day adult
11
Paraquat 10 mM 48 hrs, 4-day adult
14
Rotenone 2 μg 12 hrs, larvae L3
2
Rotenone 8 μg 12 hrs, larvae L3
3
Expression Level Scale
Very low
Low
Moderate
Linear, scaled to Moderate expression
Treatment
Expression Level
extended cold, 4-day adult
9
cold shock, 4-day adult
7
heat shock, 4-day adult
7
Cadmium 50 mM 6 hrs, larvae L3
2
Cadmium 50 mM 12 hrs, larvae L3
3
Cadmium 50 mM 48 hrs, 4-day adult
6
Cadmium 100 mM 48 hrs, 4-day adult
11
Copper 0.5 mM 12 hrs, larvae L3
4
Copper 15 mM 48 hrs, 4-day adult
4
Zinc 5 mM 12 hrs, larvae L3
4
Zinc 4.5 mM 48 hrs, 4-day adult
6
Ethanol 2.5% 3 hrs, larvae L3
14
Ethanol 5% 3 hrs, larvae L3
2
Ethanol 10% 3 hrs, larvae L3
2
Caffeine 1.5 mg/ml 4 hrs, larvae L3
2
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
12
Caffeine 25 mg/ml 48 hrs, 4-day adult
8
Paraquat 5 mM 48 hrs, 4-day adult
11
Paraquat 10 mM 48 hrs, 4-day adult
14
Rotenone 2 μg 12 hrs, larvae L3
2
Rotenone 8 μg 12 hrs, larvae L3
3
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to High expression
Treatment
Expression Level
extended cold, 4-day adult
9
cold shock, 4-day adult
7
heat shock, 4-day adult
7
Cadmium 50 mM 6 hrs, larvae L3
2
Cadmium 50 mM 12 hrs, larvae L3
3
Cadmium 50 mM 48 hrs, 4-day adult
6
Cadmium 100 mM 48 hrs, 4-day adult
11
Copper 0.5 mM 12 hrs, larvae L3
4
Copper 15 mM 48 hrs, 4-day adult
4
Zinc 5 mM 12 hrs, larvae L3
4
Zinc 4.5 mM 48 hrs, 4-day adult
6
Ethanol 2.5% 3 hrs, larvae L3
14
Ethanol 5% 3 hrs, larvae L3
2
Ethanol 10% 3 hrs, larvae L3
2
Caffeine 1.5 mg/ml 4 hrs, larvae L3
2
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
12
Caffeine 25 mg/ml 48 hrs, 4-day adult
8
Paraquat 5 mM 48 hrs, 4-day adult
11
Paraquat 10 mM 48 hrs, 4-day adult
14
Rotenone 2 μg 12 hrs, larvae L3
2
Rotenone 8 μg 12 hrs, larvae L3
3
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Extremely high expression
Treatment
Expression Level
extended cold, 4-day adult
9
cold shock, 4-day adult
7
heat shock, 4-day adult
7
Cadmium 50 mM 6 hrs, larvae L3
2
Cadmium 50 mM 12 hrs, larvae L3
3
Cadmium 50 mM 48 hrs, 4-day adult
6
Cadmium 100 mM 48 hrs, 4-day adult
11
Copper 0.5 mM 12 hrs, larvae L3
4
Copper 15 mM 48 hrs, 4-day adult
4
Zinc 5 mM 12 hrs, larvae L3
4
Zinc 4.5 mM 48 hrs, 4-day adult
6
Ethanol 2.5% 3 hrs, larvae L3
14
Ethanol 5% 3 hrs, larvae L3
2
Ethanol 10% 3 hrs, larvae L3
2
Caffeine 1.5 mg/ml 4 hrs, larvae L3
2
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
12
Caffeine 25 mg/ml 48 hrs, 4-day adult
8
Paraquat 5 mM 48 hrs, 4-day adult
11
Paraquat 10 mM 48 hrs, 4-day adult
14
Rotenone 2 μg 12 hrs, larvae L3
2
Rotenone 8 μg 12 hrs, larvae L3
3
Expression Level Scale
Extremely high
log, scaled to maximum expression level
Treatment
Expression Level
extended cold, 4-day adult
9
cold shock, 4-day adult
7
heat shock, 4-day adult
7
Cadmium 50 mM 6 hrs, larvae L3
2
Cadmium 50 mM 12 hrs, larvae L3
3
Cadmium 50 mM 48 hrs, 4-day adult
6
Cadmium 100 mM 48 hrs, 4-day adult
11
Copper 0.5 mM 12 hrs, larvae L3
4
Copper 15 mM 48 hrs, 4-day adult
4
Zinc 5 mM 12 hrs, larvae L3
4
Zinc 4.5 mM 48 hrs, 4-day adult
6
Ethanol 2.5% 3 hrs, larvae L3
14
Ethanol 5% 3 hrs, larvae L3
2
Ethanol 10% 3 hrs, larvae L3
2
Caffeine 1.5 mg/ml 4 hrs, larvae L3
2
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
12
Caffeine 25 mg/ml 48 hrs, 4-day adult
8
Paraquat 5 mM 48 hrs, 4-day adult
11
Paraquat 10 mM 48 hrs, 4-day adult
14
Rotenone 2 μg 12 hrs, larvae L3
2
Rotenone 8 μg 12 hrs, larvae L3
3
Expression Level Scale
Very low
Low
Moderate
log, scaled to Moderate expression
Treatment
Expression Level
extended cold, 4-day adult
9
cold shock, 4-day adult
7
heat shock, 4-day adult
7
Cadmium 50 mM 6 hrs, larvae L3
2
Cadmium 50 mM 12 hrs, larvae L3
3
Cadmium 50 mM 48 hrs, 4-day adult
6
Cadmium 100 mM 48 hrs, 4-day adult
11
Copper 0.5 mM 12 hrs, larvae L3
4
Copper 15 mM 48 hrs, 4-day adult
4
Zinc 5 mM 12 hrs, larvae L3
4
Zinc 4.5 mM 48 hrs, 4-day adult
6
Ethanol 2.5% 3 hrs, larvae L3
14
Ethanol 5% 3 hrs, larvae L3
2
Ethanol 10% 3 hrs, larvae L3
2
Caffeine 1.5 mg/ml 4 hrs, larvae L3
2
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
12
Caffeine 25 mg/ml 48 hrs, 4-day adult
8
Paraquat 5 mM 48 hrs, 4-day adult
11
Paraquat 10 mM 48 hrs, 4-day adult
14
Rotenone 2 μg 12 hrs, larvae L3
2
Rotenone 8 μg 12 hrs, larvae L3
3
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to High expression
Treatment
Expression Level
extended cold, 4-day adult
9
cold shock, 4-day adult
7
heat shock, 4-day adult
7
Cadmium 50 mM 6 hrs, larvae L3
2
Cadmium 50 mM 12 hrs, larvae L3
3
Cadmium 50 mM 48 hrs, 4-day adult
6
Cadmium 100 mM 48 hrs, 4-day adult
11
Copper 0.5 mM 12 hrs, larvae L3
4
Copper 15 mM 48 hrs, 4-day adult
4
Zinc 5 mM 12 hrs, larvae L3
4
Zinc 4.5 mM 48 hrs, 4-day adult
6
Ethanol 2.5% 3 hrs, larvae L3
14
Ethanol 5% 3 hrs, larvae L3
2
Ethanol 10% 3 hrs, larvae L3
2
Caffeine 1.5 mg/ml 4 hrs, larvae L3
2
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
12
Caffeine 25 mg/ml 48 hrs, 4-day adult
8
Paraquat 5 mM 48 hrs, 4-day adult
11
Paraquat 10 mM 48 hrs, 4-day adult
14
Rotenone 2 μg 12 hrs, larvae L3
2
Rotenone 8 μg 12 hrs, larvae L3
3
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Extremely high expression
Treatment
Expression Level
extended cold, 4-day adult
9
cold shock, 4-day adult
7
heat shock, 4-day adult
7
Cadmium 50 mM 6 hrs, larvae L3
2
Cadmium 50 mM 12 hrs, larvae L3
3
Cadmium 50 mM 48 hrs, 4-day adult
6
Cadmium 100 mM 48 hrs, 4-day adult
11
Copper 0.5 mM 12 hrs, larvae L3
4
Copper 15 mM 48 hrs, 4-day adult
4
Zinc 5 mM 12 hrs, larvae L3
4
Zinc 4.5 mM 48 hrs, 4-day adult
6
Ethanol 2.5% 3 hrs, larvae L3
14
Ethanol 5% 3 hrs, larvae L3
2
Ethanol 10% 3 hrs, larvae L3
2
Caffeine 1.5 mg/ml 4 hrs, larvae L3
2
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
12
Caffeine 25 mg/ml 48 hrs, 4-day adult
8
Paraquat 5 mM 48 hrs, 4-day adult
11
Paraquat 10 mM 48 hrs, 4-day adult
14
Rotenone 2 μg 12 hrs, larvae L3
2
Rotenone 8 μg 12 hrs, larvae L3
3
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Heatmap
Treatment
Expression Level
extended cold, 4-day adult
cold shock, 4-day adult
heat shock, 4-day adult
Cadmium 50 mM 6 hrs, larvae L3
Cadmium 50 mM 12 hrs, larvae L3
Cadmium 50 mM 48 hrs, 4-day adult
Cadmium 100 mM 48 hrs, 4-day adult
Copper 0.5 mM 12 hrs, larvae L3
Copper 15 mM 48 hrs, 4-day adult
Zinc 5 mM 12 hrs, larvae L3
Zinc 4.5 mM 48 hrs, 4-day adult
Ethanol 2.5% 3 hrs, larvae L3
Ethanol 5% 3 hrs, larvae L3
Ethanol 10% 3 hrs, larvae L3
Caffeine 1.5 mg/ml 4 hrs, larvae L3
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
Caffeine 25 mg/ml 48 hrs, 4-day adult
Paraquat 5 mM 48 hrs, 4-day adult
Paraquat 10 mM 48 hrs, 4-day adult
Rotenone 2 μg 12 hrs, larvae L3
Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
A cluster of genes with similar mRNA expression dynamics across development.
External Data & Images
Linkouts
- Cell culture data for RNAi and other high-throughput technologies
- Adult expression by tissue, using Affymetrix Dros2 array
Alleles & Phenotypes Summary of Allele Phenotypes Classical Alleles ( 20 ) For All Classical Alleles Show Alleles Carried on Transgenic Constructs
( 5 ) For All Alleles Carried on Transgenic
Constructs Show Aneuploid Aberrations Disrupted in Transgenic Constructs & Insertions
Transgenic Constructs characterization construct
Insertions insertion of enhancer trap binary system
Gene Ontology: Function, Process
& Cellular Component ( 5 unique terms ) Terms Based on
Experimental Evidence ( 5 terms ) Molecular Function inferred from physical interaction with
dlg1 inferred from physical interaction with
scrib Biological Process inferred from mutant phenotype
inferred from mutant phenotype
Cellular Component inferred from direct assay
inferred from direct assay
Terms Based on Predictions or
Assertions ( 0 terms ) Sequence Ontology: Class of Gene Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions Interacts with Please look at the allele data
for full details of the genetic interactions
External Data Linkouts
- A comprehensive database of gene and protein interactions.
Orthologs
OrthoDB Orthologs (6)
- based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
OrthoDB orthology group searches
Drosophila inclusive ortholog search
Dipteran inclusive ortholog search
No orthologs identified
Insect inclusive ortholog search
No orthologs identified
Arthropod inclusive ortholog search
No orthologs identified
Metazoa inclusive ortholog search
No orthologs identified
Orthologs in Drosophila Species
(EOG68WCMB )
Drosophila melanogaster
fruit fly
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (None identified)
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)AAA Orthologs (11)
based on analysis using Dmel annotation version 4.3
Drosophila pseudoobscura pseudoobscura
Stocks & Reagents Stocks Listed in FlyBase ( 11 )Bloomington Harvard Kyoto Genomic Clones ( 2 )Please Note FlyBase no
longer curates genomic clone accessions so this list
may not be complete
cDNA Clones ( 52 )Please Note This section lists
cDNAs and ESTs that fall within the genomic extent
of the gene model, which may include cDNAs and ESTs
of genes within introns, or of overlapping genes.
Please see
GBrowse for alignment of the cDNAs and ESTs
to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones Other clones cDNA Clones, End Sequenced
(ESTs) BDGP DGC clones Other clones RNAi & Array Information Linkouts
- Results from RNAi screens.
- GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
Antibody Information
Other Information Discoverer Etymology Identification Relationship to Other Genes Source for database identity of Source for database merge of Source for merge of: CG6003 CG14287
Source for merge of: CG6003 gukh CG5456 CG14288
Source for merge of: gukh anon-WO0118547.205
Additional comments Annotations CG14288, CG5456, CG6003 merged as CG31043 in release 3 of the genome annotation.
Source for merge of gukh anon-WO0118547.205 was sequence comparison (date:051113).
Other Comments Area matching Drosophila EST AA695424.
Identification: Defined in a yeast two-hybrid system as an interactor with the
dlg1 protein.
External Crossreferences & Linkouts
Sequence Crossreferences
- A searchable database of RefSeq genes.
Other Crossreferences
- Patterns of gene expression in Drosophila embryogenesis
Linkouts
- A comprehensive database of gene and protein interactions.
- Results from RNAi screens.
- Cell culture data for RNAi and other high-throughput technologies
- Adult expression by tissue, using Affymetrix Dros2 array
- Integrated genomics database for Drosophila, Anopheles, and C.elegans
- GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
- A cyberspace guide to Drosophila development and metazoan evolution
- Data generated by the modENCODE project.
Synonyms & Secondary IDs
( 16 )Reported As Symbol Synonym gukh
(
Mathew et al., 2002 ,
Buszczak et al., 2007 ,
Frise et al., 2010 ,
Levis et al., 2011.12.16 ,
Wasbrough et al., 2010 ,
Mackay et al., 2012 )
Name Synonym Secondary FlyBase
IDs FBgn0038668 FBgn0038669 FBgn0038670 FBgn0038671 FBgn0051043 FBgn0062172 References ( 38 )Generate a list of List References by type
Recent research papers ( 2 )
Mackay et al., 2012, Nature 482(7384): 173--178The Drosophila melanogaster Genetic Reference Panel. [FBrf0217434] Weber et al., 2012, PLoS ONE 7(4): e34745Genome-Wide Association Analysis of Oxidative Stress Resistance in Drosophila melanogaster. [FBrf0218073]
Recent reviews (0)
All reviews listed in FlyBase were published before 2011