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Gene Dmel\eIF-1A

General Information
Symbol	Dmel\eIF-1A	Species	D. melanogaster
Name	Eukaryotic initiation factor 1A	Annotation symbol	CG8053
Feature type	protein_coding_gene	FlyBase ID	FBgn0026250
Gene Model Status	Current	Stock availability	11 publicly available
Also Known As	eIF1A, group I, D-eIF1A
Genomic Location
Chromosome (arm)	3R	Recombination map	3-
Cytogenetic map	91A1-91A1	Sequence location	3R:14,100,387..14,108,206 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Eukaryotic initiation factor 1A is referred to in FlyBase by the symbol Dmel\eIF-1A (CG8053, FBgn0026250). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: translation initiation factor activity. There is experimental evidence that it is involved in the biological process: smoothened signaling pathway; mitotic spindle elongation; mitotic spindle organization; phagocytosis, engulfment. 14 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Nucleic acid-binding, OB-fold; Nucleic acid-binding, OB-fold-like; RNA-binding domain, S1, IF1 type; Translation initiation factor 1A (eIF-1A); Translation initiation factor 1A (eIF-1A), conserved site. Summary of modENCODE Temporal Expression Profile: Very high expression at all stages of development. Summary of FlyAtlas Anatomical Expression Data: High levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1640435_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of eIF-1A. Gene sequence location is 3R:14100387..14108206.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	References Knowles-Barley, 2011.8.24, BrainTrap expression curation.
FB2012_01	Sequence features HFA16937 BKN28681
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 91A1-91A1   Limits computationally determined from genome sequence between P{EP}cpoEP3679 and P{EP}Dlc90FEP3634
Experimentally Determined Cytological Location
Cytogenetic map Notes References 90E-91A     (Myrick, 1999.7.15) 90E-91A   Cytological location determined by hybridization to cytologically mapped P1 clones.   (Dearolf, 1999.3.5) 90E-91A   Map location based on hybridisation to P1 clones.   (Myrick and Dearolf, 2000)
Experimentally Determined Recombination Data
Location	3- (Collins, 2005)
Left of (cM)	e (Collins, 2005)
Right of (cM)	sr (Collins, 2005)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\eIF-1A for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) eIF-1A-RA FBtr0083572  NM_079989   1158   148 eIF-1A-RB FBtr0083573  NM_206509   1199   148
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein eIF-1A-PA   FBpp0082994   17.1   148   4.85     NP_524728   AAF55526 eIF-1A-PB   FBpp0089421   17.1   148   4.85     NP_996231   AAS65169
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Translation initiation factor 1A (eIF-1A), conserved site (IPR018104) Translation initiation factor 1A (eIF-1A) (IPR001253) RNA-binding domain, S1, IF1 type (IPR006196) Nucleic acid-binding, OB-fold (IPR012340) Nucleic acid-binding, OB-fold-like (IPR016027)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA540344   AA696098   AA696607   AA820285   AA940912   AE014297 AAF55526   AE014297 AAS65169   AF083296   AF169359 AAF44294   AI124295   AI258809   AI403688   AI406212   AI944468   AQ025290   AQ073936   AQ254678   AY113498 AAM29503   AY231877   AY440677   BE978722   BF496139   BG635574   BI165853   BI166167   BI168098   BI170304   BI172127   BI212992   BI239258   BI241580   BI242370   BI354274   BI354361   BI354393   BI356145   BI362175   BI365115   BI368809   BI372015   BI482748   BI564927   BI566509   BI570690   BI572178   BI572288   BI591682   BI591683   BI606761   BI611812   BI612374   BI622590   BI626198   BI631496   BI637870   BI638283   BI639004   BI640612   BP542703   BP542891   BP542892   BP554739   BP554740   BX007241   BX012343   BX014299   BX014664   BX020518   BX027186   BX028128   BX037875   BX039493   BX040727   BX041663   BX041679   BX041733   BX042121   BX045363   BX048298   BX049255   BX049396   BX055416   BX055860   BX058990   BX059172   BX060361   BX060512   BX061550   BX062064   BX062360   BX062460   BX063047   BX063309   BX067300   BX067327   BX071700   CA804561   CA805006   CA806442   CK131433   CK660426   CK661437   CL527770   CO180919   CO183364   CO189677   CO190368   CO262261   CO264712   CO266203   CO271866   CO275117   CO276895   CO278052   CO279630   CO281792   CO283529   CO289484   CO300722   CO301792   CO304201   CO304783   CO307590   CO312585   CO316574   CO319566   CO322923   CO322932   CO324458   CO333576   CO336959   CO338456   CZ469329   DQ440400   EC063124   EC063353   EC070526   EC072856   EC074030   EC076451   EC080792   EC084035   EC084459   EC088646   EC090776   EC195052   EC195536   EC200626   EC203311   EC204021   EC207687   EC207954   EC211114   EC221114   EC221349   EC223262   EC237807   EC243590   EC245843   EC247561   EC249424   EC250118   EC266055   ES689403   ES689523   ES693424   EV575122   EV576197   EV581406   EV582438   EV590478   EV596988   EV598318   EV600772   GH941425   GH941624   GH944050   GH945117   GH945544   GH947201   GH947842   GH947888   GH948009   GH948106   GH949319   GH949682   GH950475   GH951164   GH951190   GH952155   GH952472   GH953004   GH957079   GH959085   GH959346   GH961635   GH963673   GH963861   GH964743   GH966032   GH966390   GH966543   GH967218   GH968807   GH970026   GH970252   GH974412   GH974649   GH974810   GH975490   GH975837   GH976906   GH977162   GH977949   GH978865   GH981669   GH982083   GH983331   GH983428   GH983522   GH983863
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9NJB4 Q9VEA1
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0026250    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0026250 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Very high expression at all stages of development. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0026250 expression level Developmental Stage   Expression Level embryo 00-02hr    18739 embryo 02-04hr    13714 embryo 04-06hr    16405 embryo 06-08hr    20170 embryo 08-10hr    18987 embryo 10-12hr    20073 embryo 12-14hr    18170 embryo 14-16hr    18627 embryo 16-18hr    17894 embryo 18-20hr    16957 embryo 20-22hr    16461 embryo 22-24hr    17172 larva L1    22686 larva L2    21435 larva L3 12hr old    17457 larva L3 puffstage 1-2    14508 larva L3 puffstage 3-6    18512 larva L3 puffstage 7-9    23012 white prepupae new    25819 white prepupae 12hr    24721 white prepupae 24hr    21607 pupae 2d postWPP    19975 pupae 3d postWPP    16321 pupae 4d postWPP    21386 adult male 01day    21368 adult male 05day    20068 adult male 30day    19473 adult female 01day    21080 adult female 05day    19795 adult female 30day    19253 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (18739) embryo 02-04hr  (13714) embryo 04-06hr  (16405) embryo 06-08hr  (20170) embryo 08-10hr  (18987) embryo 10-12hr  (20073) embryo 12-14hr  (18170) embryo 14-16hr  (18627) embryo 16-18hr  (17894) embryo 18-20hr  (16957) embryo 20-22hr  (16461) embryo 22-24hr  (17172) larva L1  (22686) larva L2  (21435) larva L3 12hr old  (17457) larva L3 puffstage 1-2  (14508) larva L3 puffstage 3-6  (18512) larva L3 puffstage 7-9  (23012) white prepupae new  (25819) white prepupae 12hr  (24721) white prepupae 24hr  (21607) pupae 2d postWPP  (19975) pupae 3d postWPP  (16321) pupae 4d postWPP  (21386) adult male 01day  (21368) adult male 05day  (20068) adult male 30day  (19473) adult female 01day  (21080) adult female 05day  (19795) adult female 30day  (19253) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (18739) embryo 02-04hr  (13714) embryo 04-06hr  (16405) embryo 06-08hr  (20170) embryo 08-10hr  (18987) embryo 10-12hr  (20073) embryo 12-14hr  (18170) embryo 14-16hr  (18627) embryo 16-18hr  (17894) embryo 18-20hr  (16957) embryo 20-22hr  (16461) embryo 22-24hr  (17172) larva L1  (22686) larva L2  (21435) larva L3 12hr old  (17457) larva L3 puffstage 1-2  (14508) larva L3 puffstage 3-6  (18512) larva L3 puffstage 7-9  (23012) white prepupae new  (25819) white prepupae 12hr  (24721) white prepupae 24hr  (21607) pupae 2d postWPP  (19975) pupae 3d postWPP  (16321) pupae 4d postWPP  (21386) adult male 01day  (21368) adult male 05day  (20068) adult male 30day  (19473) adult female 01day  (21080) adult female 05day  (19795) adult female 30day  (19253) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (18739) embryo 02-04hr  (13714) embryo 04-06hr  (16405) embryo 06-08hr  (20170) embryo 08-10hr  (18987) embryo 10-12hr  (20073) embryo 12-14hr  (18170) embryo 14-16hr  (18627) embryo 16-18hr  (17894) embryo 18-20hr  (16957) embryo 20-22hr  (16461) embryo 22-24hr  (17172) larva L1  (22686) larva L2  (21435) larva L3 12hr old  (17457) larva L3 puffstage 1-2  (14508) larva L3 puffstage 3-6  (18512) larva L3 puffstage 7-9  (23012) white prepupae new  (25819) white prepupae 12hr  (24721) white prepupae 24hr  (21607) pupae 2d postWPP  (19975) pupae 3d postWPP  (16321) pupae 4d postWPP  (21386) adult male 01day  (21368) adult male 05day  (20068) adult male 30day  (19473) adult female 01day  (21080) adult female 05day  (19795) adult female 30day  (19253) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    18739 embryo 02-04hr    13714 embryo 04-06hr    16405 embryo 06-08hr    20170 embryo 08-10hr    18987 embryo 10-12hr    20073 embryo 12-14hr    18170 embryo 14-16hr    18627 embryo 16-18hr    17894 embryo 18-20hr    16957 embryo 20-22hr    16461 embryo 22-24hr    17172 larva L1    22686 larva L2    21435 larva L3 12hr old    17457 larva L3 puffstage 1-2    14508 larva L3 puffstage 3-6    18512 larva L3 puffstage 7-9    23012 white prepupae new    25819 white prepupae 12hr    24721 white prepupae 24hr    21607 pupae 2d postWPP    19975 pupae 3d postWPP    16321 pupae 4d postWPP    21386 adult male 01day    21368 adult male 05day    20068 adult male 30day    19473 adult female 01day    21080 adult female 05day    19795 adult female 30day    19253 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0026250 expression level Developmental Stage   Expression Level embryo 00-02hr    18739 embryo 02-04hr    13714 embryo 04-06hr    16405 embryo 06-08hr    20170 embryo 08-10hr    18987 embryo 10-12hr    20073 embryo 12-14hr    18170 embryo 14-16hr    18627 embryo 16-18hr    17894 embryo 18-20hr    16957 embryo 20-22hr    16461 embryo 22-24hr    17172 larva L1    22686 larva L2    21435 larva L3 12hr old    17457 larva L3 puffstage 1-2    14508 larva L3 puffstage 3-6    18512 larva L3 puffstage 7-9    23012 white prepupae new    25819 white prepupae 12hr    24721 white prepupae 24hr    21607 pupae 2d postWPP    19975 pupae 3d postWPP    16321 pupae 4d postWPP    21386 adult male 01day    21368 adult male 05day    20068 adult male 30day    19473 adult female 01day    21080 adult female 05day    19795 adult female 30day    19253 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (18739) embryo 02-04hr  (13714) embryo 04-06hr  (16405) embryo 06-08hr  (20170) embryo 08-10hr  (18987) embryo 10-12hr  (20073) embryo 12-14hr  (18170) embryo 14-16hr  (18627) embryo 16-18hr  (17894) embryo 18-20hr  (16957) embryo 20-22hr  (16461) embryo 22-24hr  (17172) larva L1  (22686) larva L2  (21435) larva L3 12hr old  (17457) larva L3 puffstage 1-2  (14508) larva L3 puffstage 3-6  (18512) larva L3 puffstage 7-9  (23012) white prepupae new  (25819) white prepupae 12hr  (24721) white prepupae 24hr  (21607) pupae 2d postWPP  (19975) pupae 3d postWPP  (16321) pupae 4d postWPP  (21386) adult male 01day  (21368) adult male 05day  (20068) adult male 30day  (19473) adult female 01day  (21080) adult female 05day  (19795) adult female 30day  (19253) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (18739) embryo 02-04hr  (13714) embryo 04-06hr  (16405) embryo 06-08hr  (20170) embryo 08-10hr  (18987) embryo 10-12hr  (20073) embryo 12-14hr  (18170) embryo 14-16hr  (18627) embryo 16-18hr  (17894) embryo 18-20hr  (16957) embryo 20-22hr  (16461) embryo 22-24hr  (17172) larva L1  (22686) larva L2  (21435) larva L3 12hr old  (17457) larva L3 puffstage 1-2  (14508) larva L3 puffstage 3-6  (18512) larva L3 puffstage 7-9  (23012) white prepupae new  (25819) white prepupae 12hr  (24721) white prepupae 24hr  (21607) pupae 2d postWPP  (19975) pupae 3d postWPP  (16321) pupae 4d postWPP  (21386) adult male 01day  (21368) adult male 05day  (20068) adult male 30day  (19473) adult female 01day  (21080) adult female 05day  (19795) adult female 30day  (19253) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  18739 embryo 02-04hr  13714 embryo 04-06hr  16405 embryo 06-08hr  20170 embryo 08-10hr  18987 embryo 10-12hr  20073 embryo 12-14hr  18170 embryo 14-16hr  18627 embryo 16-18hr  17894 embryo 18-20hr  16957 embryo 20-22hr  16461 embryo 22-24hr  17172 larva L1  (22686) larva L2  (21435) larva L3 12hr old  17457 larva L3 puffstage 1-2  14508 larva L3 puffstage 3-6  18512 larva L3 puffstage 7-9  (23012) white prepupae new  (25819) white prepupae 12hr  (24721) white prepupae 24hr  (21607) pupae 2d postWPP  19975 pupae 3d postWPP  16321 pupae 4d postWPP  (21386) adult male 01day  (21368) adult male 05day  20068 adult male 30day  19473 adult female 01day  (21080) adult female 05day  19795 adult female 30day  19253 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    18739 embryo 02-04hr    13714 embryo 04-06hr    16405 embryo 06-08hr    20170 embryo 08-10hr    18987 embryo 10-12hr    20073 embryo 12-14hr    18170 embryo 14-16hr    18627 embryo 16-18hr    17894 embryo 18-20hr    16957 embryo 20-22hr    16461 embryo 22-24hr    17172 larva L1    22686 larva L2    21435 larva L3 12hr old    17457 larva L3 puffstage 1-2    14508 larva L3 puffstage 3-6    18512 larva L3 puffstage 7-9    23012 white prepupae new    25819 white prepupae 12hr    24721 white prepupae 24hr    21607 pupae 2d postWPP    19975 pupae 3d postWPP    16321 pupae 4d postWPP    21386 adult male 01day    21368 adult male 05day    20068 adult male 30day    19473 adult female 01day    21080 adult female 05day    19795 adult female 30day    19253 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0026250    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0026250 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0026250 expression level Tissue   Expression Level Larval Central Nervous System    1390.325 Larval Midgut    1237.3 Larval Hindgut    1723.3 Larval Malpighian Tubules    2301 Larval Fat Body    2299.6 Larval Salivary Gland    3171.6 Larval Trachea    2147.175 Larval Carcass    2140.575 Adult Head    1779.5 Adult Eye    2272.6 Adult Brain    1480.5 Adult Thoracic-Abdominal Ganglion    1442.3 Adult Crop    1964.6 Adult Midgut    1917.4 Adult Hindgut    2005.8 Adult Malpighian Tubules    2448.2 Adult Fat Body    2462.4 Adult Salivary Gland    2867.7 Adult Heart    1835.6 Adult VirginFemale Spermatheca    2736.8 Adult InseminatedFemale Spermatheca    2513 Adult Ovary    1478.5 Adult Testis    1729 Adult Male Accessory Gland    2796.8 Adult Carcass    1754.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1390.325) Larval Midgut  (1237.3) Larval Hindgut  (1723.3) Larval Malpighian Tubules  (2301) Larval Fat Body  (2299.6) Larval Salivary Gland  (3171.6) Larval Trachea  (2147.175) Larval Carcass  (2140.575) Adult Head  (1779.5) Adult Eye  (2272.6) Adult Brain  (1480.5) Adult Thoracic-Abdominal Ganglion  (1442.3) Adult Crop  (1964.6) Adult Midgut  (1917.4) Adult Hindgut  (2005.8) Adult Malpighian Tubules  (2448.2) Adult Fat Body  (2462.4) Adult Salivary Gland  (2867.7) Adult Heart  (1835.6) Adult VirginFemale Spermatheca  (2736.8) Adult InseminatedFemale Spermatheca  (2513) Adult Ovary  (1478.5) Adult Testis  (1729) Adult Male Accessory Gland  (2796.8) Adult Carcass  (1754.2) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (1390.325) Larval Midgut  (1237.3) Larval Hindgut  (1723.3) Larval Malpighian Tubules  (2301) Larval Fat Body  (2299.6) Larval Salivary Gland  (3171.6) Larval Trachea  (2147.175) Larval Carcass  (2140.575) Adult Head  (1779.5) Adult Eye  (2272.6) Adult Brain  (1480.5) Adult Thoracic-Abdominal Ganglion  (1442.3) Adult Crop  (1964.6) Adult Midgut  (1917.4) Adult Hindgut  (2005.8) Adult Malpighian Tubules  (2448.2) Adult Fat Body  (2462.4) Adult Salivary Gland  (2867.7) Adult Heart  (1835.6) Adult VirginFemale Spermatheca  (2736.8) Adult InseminatedFemale Spermatheca  (2513) Adult Ovary  (1478.5) Adult Testis  (1729) Adult Male Accessory Gland  (2796.8) Adult Carcass  (1754.2) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1390.325 Larval Midgut    1237.3 Larval Hindgut    1723.3 Larval Malpighian Tubules    2301 Larval Fat Body    2299.6 Larval Salivary Gland    3171.6 Larval Trachea    2147.175 Larval Carcass    2140.575 Adult Head    1779.5 Adult Eye    2272.6 Adult Brain    1480.5 Adult Thoracic-Abdominal Ganglion    1442.3 Adult Crop    1964.6 Adult Midgut    1917.4 Adult Hindgut    2005.8 Adult Malpighian Tubules    2448.2 Adult Fat Body    2462.4 Adult Salivary Gland    2867.7 Adult Heart    1835.6 Adult VirginFemale Spermatheca    2736.8 Adult InseminatedFemale Spermatheca    2513 Adult Ovary    1478.5 Adult Testis    1729 Adult Male Accessory Gland    2796.8 Adult Carcass    1754.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0026250 expression level Tissue   Expression Level Larval Central Nervous System    1390.325 Larval Midgut    1237.3 Larval Hindgut    1723.3 Larval Malpighian Tubules    2301 Larval Fat Body    2299.6 Larval Salivary Gland    3171.6 Larval Trachea    2147.175 Larval Carcass    2140.575 Adult Head    1779.5 Adult Eye    2272.6 Adult Brain    1480.5 Adult Thoracic-Abdominal Ganglion    1442.3 Adult Crop    1964.6 Adult Midgut    1917.4 Adult Hindgut    2005.8 Adult Malpighian Tubules    2448.2 Adult Fat Body    2462.4 Adult Salivary Gland    2867.7 Adult Heart    1835.6 Adult VirginFemale Spermatheca    2736.8 Adult InseminatedFemale Spermatheca    2513 Adult Ovary    1478.5 Adult Testis    1729 Adult Male Accessory Gland    2796.8 Adult Carcass    1754.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1390.325) Larval Midgut  (1237.3) Larval Hindgut  (1723.3) Larval Malpighian Tubules  (2301) Larval Fat Body  (2299.6) Larval Salivary Gland  (3171.6) Larval Trachea  (2147.175) Larval Carcass  (2140.575) Adult Head  (1779.5) Adult Eye  (2272.6) Adult Brain  (1480.5) Adult Thoracic-Abdominal Ganglion  (1442.3) Adult Crop  (1964.6) Adult Midgut  (1917.4) Adult Hindgut  (2005.8) Adult Malpighian Tubules  (2448.2) Adult Fat Body  (2462.4) Adult Salivary Gland  (2867.7) Adult Heart  (1835.6) Adult VirginFemale Spermatheca  (2736.8) Adult InseminatedFemale Spermatheca  (2513) Adult Ovary  (1478.5) Adult Testis  (1729) Adult Male Accessory Gland  (2796.8) Adult Carcass  (1754.2) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  1390.325 Larval Midgut  1237.3 Larval Hindgut  (1723.3) Larval Malpighian Tubules  (2301) Larval Fat Body  (2299.6) Larval Salivary Gland  (3171.6) Larval Trachea  (2147.175) Larval Carcass  (2140.575) Adult Head  (1779.5) Adult Eye  (2272.6) Adult Brain  1480.5 Adult Thoracic-Abdominal Ganglion  1442.3 Adult Crop  (1964.6) Adult Midgut  (1917.4) Adult Hindgut  (2005.8) Adult Malpighian Tubules  (2448.2) Adult Fat Body  (2462.4) Adult Salivary Gland  (2867.7) Adult Heart  (1835.6) Adult VirginFemale Spermatheca  (2736.8) Adult InseminatedFemale Spermatheca  (2513) Adult Ovary  1478.5 Adult Testis  (1729) Adult Male Accessory Gland  (2796.8) Adult Carcass  (1754.2) Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1390.325 Larval Midgut    1237.3 Larval Hindgut    1723.3 Larval Malpighian Tubules    2301 Larval Fat Body    2299.6 Larval Salivary Gland    3171.6 Larval Trachea    2147.175 Larval Carcass    2140.575 Adult Head    1779.5 Adult Eye    2272.6 Adult Brain    1480.5 Adult Thoracic-Abdominal Ganglion    1442.3 Adult Crop    1964.6 Adult Midgut    1917.4 Adult Hindgut    2005.8 Adult Malpighian Tubules    2448.2 Adult Fat Body    2462.4 Adult Salivary Gland    2867.7 Adult Heart    1835.6 Adult VirginFemale Spermatheca    2736.8 Adult InseminatedFemale Spermatheca    2513 Adult Ovary    1478.5 Adult Testis    1729 Adult Male Accessory Gland    2796.8 Adult Carcass    1754.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    1779.5   NA  Eye    2272.6   NA  Brain    1480.5   1390.325  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    1442.3   NA  Crop    1964.6   1237.3  Midgut    1917.4   1723.3  Hindgut    2005.8   2301  Malpighian Tubules    2448.2   2299.6  Fat Body    2462.4   3171.6  Salivary Gland    2867.7   NA  Heart    1835.6   2147.175  Trachea    NA   NA  VirginFemale Spermatheca    2736.8   NA  InseminatedFemale Spermatheca    2513   NA  Ovary    1478.5   NA  Testis    1729   NA  Male Accessory Gland    2796.8   2140.575  Carcass    1754.2 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_25
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0026250 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8053-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele cell lethal | somatic clone eIF-1Aunspecified lethal, with Scer\GAL4pnr-MD237 eIF-1AGD10618 lethal | recessive eIF-1A645 eIF-1A2232 viable eIF-1AEY04874 Sterility Allele fertile eIF-1AEY04874 Phenotype manifest in Allele
Classical Alleles ( 10 )
For All Classical Alleles Show
Allele of eIF-1A Class Mutagen Stocks Known lesion eIF-1Ac04533 piggyBac transposase 2 -- eIF-1A2232 ethyl methanesulfonate 1 -- eIF-1A645 ethyl methanesulfonate 1 -- eIF-1ADG10506 1 -- eIF-1AEP935 P-element activity 1 -- eIF-1AEY04874 P-element activity 1 -- eIF-1ACPTI002562 piggyBac transposase 0 Yes eIF-1AEP3112 P-element activity 0 -- eIF-1AEP3350 P-element activity 0 -- eIF-1Aunspecified 0 --
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of eIF-1A Class Mutagen Stocks Known lesion eIF-1AGD10618 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes eIF-1AJF01698 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes eIF-1AJF02475 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes eIF-1AKK108681 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Cha7 (Collins, 2005) Df(3R)Exel6178 (Ryder, 2004.4.26)
Not disrupted in	Df(3R)Cha1a (Collins, 2005) Df(3R)DG4 (Collins, 2005)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD10618} NA P{KK108681} NA P{TRiP.JF01698} NA P{TRiP.JF02475} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}eIF-1AEP935 NA P{EP}eIF-1AEP3112 NA P{EP}eIF-1AEP3350 NA P{EPgy2}eIF-1AEY04874 NA miscellaneous insertions P{wHy}eIF-1ADG10506 NA PBac{754.P.FSVS-0}eIF-1ACPTI002562 NA PBac{PB}eIF-1Ac04533 NA
Gene Ontology: Function, Process & Cellular Component ( 9 unique terms )
Terms Based on Experimental Evidence ( 4 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
mitotic spindle elongation inferred from mutant phenotype (Goshima et al., 2007) mitotic spindle organization inferred from mutant phenotype (Goshima et al., 2007) phagocytosis, engulfment inferred from mutant phenotype (Stroschein-Stevenson et al., 2006) smoothened signaling pathway inferred from genetic interaction with smo (Collins, 2005)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
translation initiation factor activity inferred from sequence or structural similarity (Liang and Biggin, 1998, Lasko, 2000) inferred from sequence or structural similarity with human EIF1AX (Myrick and Dearolf, 1999)
Biological Process
CV term Evidence References
translation inferred from sequence or structural similarity (Liang and Biggin, 1998) inferred from sequence or structural similarity with human EIF1AX (Myrick and Dearolf, 1999) translational initiation inferred from electronic annotation with InterPro:IPR001253, InterPro:IPR006196, InterPro:IPR018104 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Lasko, 2000) non-traceable author statement (Myrick, 1999.7.15)
Cellular Component
CV term Evidence References
cytosol inferred from sequence or structural similarity (Liang and Biggin, 1998) non-traceable author statement (Myrick, 1999.7.15) eukaryotic 43S preinitiation complex inferred from sequence or structural similarity (Lasko, 2000)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions eIF-1A allele Gene References eIF-1A645 smo (Collins, 2005, Collins, 2005.7.7) eIF-1A2232 smo (Collins, 2005.7.7) eIF-1AEP935 pnr (Pena-Rangel et al., 2002)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 68927 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0026250 DroID - A comprehensive database of gene and protein interactions. • FBgn0026250 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 44260
Orthologs
Genome-wide drosophilid orthologs	Dana\GF23078 Dere\GG22826 Dgri\GH22399 Dmoj\GI24484 Dper\GL21704 Dpse\GA20792 Dsec\GM15296 Dsim\GD19223 Dvir\GJ24550 Dwil\GK22392 Dyak\eIF-1A
Curated drosophilid orthologs	Dpse\GA20792   Dyak\eIF-1A
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL004378-PA Aedes aegypti (mosquito) AGAP003119-PA Anopheles gambiae (mosquito) XP_001120011.1 Apis mellifera (honey bee) XP_001949715.1 Acyrthosiphon pisum (pea aphid) XP_001951024.1 Acyrthosiphon pisum (pea aphid) At2g04520.1 Arabidopsis thaliana (wall cress) At5g35680.1 Arabidopsis thaliana (wall cress) 6504 Batrachochytrium dendrobatidis (chytrid fungus) BGIBMGA006840-PA Bombyx mori (silk worm) ENSBTAP00000023455 Bos taurus (bovine) CAL0004326 Candida albicans (a form of yeast) CN25795 Caenorhabditis brenneri (small nematode) CBP02836 Caenorhabditis briggsae (nematode) CE17962 Caenorhabditis elegans (worm) ENSCAFP00000019328 Canis familiaris (dog) CAGL0H02409g Candida glabrata (haploid yeast) Chro.80386 Cryptosporidium hominis (obligate parasite) ENSCINP00000012866 Ciona intestinalis (sea squirt) JA12696 Caenorhabditis japonica (nematode) CMQ117C Cyanidioschyzon merolae (red alga) cn12114 Cryptococcus neoformans (yeast-like fungus) cgd8_3330 Cryptosporidium parvum (protozoan parasite) CPIJ016188 Culex pipens (mosquito) CPIJ019653 Culex pipens (mosquito) ENSCPOP00000019112 Cavia porcellus (guinea pig) 141865 Chlamidomonas reinhardtii (green alga) ENSCSAVP00000008325 Ciona savignyi (sedentary tunicate) 226988 Capitella spl (polychaete worm) DDB0234174 Dictyostelium discoideum (amoeba) DEHA2F06666g Debaryomyces Hansenii (yeast) 307936 Daphnia pulex (daphnia) ENSDARP00000066644 Danio rerio (zebra fish) ENSDARP00000075117 Danio rerio (zebra fish) ENSECAP00000004767 Equus caballus (horse) XP_652433 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000016987 Gymnopilus aculeatus (mushroom) ENSGALP00000026418 Gallus gallus (chicken) GL50803_8708 Giardia lamblia (flagellated protozoan) 84675 Hypsipyla robusta (cedar shoot borer) ENSP00000354722 Homo sapiens (human) ENSP00000368927 Homo sapiens (human) ISCW008220-PA Ixodes scapularis (deer tick) KLLA0E11287g Kluyveromyces lactis (yeast) 131336 Lottia gigantea (owl limpet) LmjF16.0140 Leishmania major (virus) 38832 Monocosta brevicollis (choanoflagellate) ENSMODP00000010076 Monodelphis domestica (gray opossum) ENSMMUP00000000270 Macaca mulatta (rhesus monkey) ENSMUSP00000077223 Mus musculus (house mouse) ENSMUSP00000084387 Mus musculus (house mouse) 193909 Nematostella vectensis (starlet anemone) XP_001606993.1 Nasonia vitripennis (wasp) ENSOANP00000021584 Ornithorynchus anatinus (platypus) ENSORLP00000003034 Oryzias latipes (japanese killifish) LOC_Os06g23440.1 Oryza sativa (asian rice) 7313 Ostreococcus tauri (green alga) PF11_0447 Plasmodium falciparum (protozoal parasite) PHUM004160-PA Pediculus humanus (human body louse) PP21862 Pristionchus pacificus (nematode) 158714 Physcomitrella patens (moss) 65162 Physcomitrella patens (moss) ENSPPYP00000022574 Pongo pygmaeus (orangutan) 71102 Phytophthora ramorum (sudden oak death pathogen) 156275 Phytophthora sojae (root rot pathogen) 645034 Populus trichocarpa (black cottonwood) 732377 Populus trichocarpa (black cottonwood) ENSPTRP00000038797 Pan troglodytes (chimpanzee) PVX_092775 Plasmodium vivax (protozoal parasite) ENSRNOP00000046345 Rattus norvegicus (norway rat) 148576 Sorghum bicolor (sorghum) YMR260C Saccharomyces cerevisiae (budding yeast) Smp_024880.1 Schistosoma mansoni (trematode parasite) SPBC25H2.07 Schizosaccharomyces pombe (fission yeast) XP_001196085.1 Strongylocentrotus purpuratus (purple sea urchin) 50975 Trichoplax adhaerens (metazoa) TA14970 Theileria annulata (apicomplexan parasite) XP_967161.1 Tribolium castaneum (red flour beetle) Tc00.1047053506743.4 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000007207 Tetraodon nigroviridis (green spotted pufferfish) TP02_0767 Theileria parva (parasitic protozoan) 595 Thalassiosira pseudonana (marine diatom) ENSTRUP00000017233 Takifugu rubripes (pufferfish Takifugu) 3715.m00109 Tetrahymena thermophila (ciliate protozoa) 81202.m00108 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000054137 Xenopus tropicalis (frog) YALI0F21153g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV14671 LH17904 ISCW008220 FBgn0067983 FBgn0224371 FBgn0211630 FBgn0190728 FBgn0170216 JGI_V11_307936 FBgn0080782 FBgn0159297 FBgn0147206 FBgn0129857 FBgn0114986 FBgn0100072 CPIJ016188 CPIJ019653 BGIBMGA006840 ACYPI003855 ACYPI003565 GB13540 AGAP003119 AAEL004378 PB24200 PHUM134070 GLEAN_03838
Stocks & Reagents
Stocks Listed in FlyBase ( 11 )
Bloomington	29316 y1 v1; P{TRiP.JF02475}attP2 31185 y1 v1; P{TRiP.JF01698}attP2 23941 w1118; eIF-1A2232/TM6B, Tb1 21496 y1 w67c23; P{wHy}eIF-1ADG10506 16621 y1 w67c23; P{EPgy2}eIF-1AEY04874 17203 w1118; P{EP}eIF-1AEP935/TM6B, Tb1 11495 w1118; PBac{PB}eIF-1Ac04533/TM6B, Tb1 23925 w1118; +/CyO; eIF-1A645/TM6C, AntpHu Sb1 Tb1
Harvard	- PBac{PB}eIF-1Ac04533
VDRC	v100611 P{KK108681}VIE-260B v26022 w1118; P{GD10618}v26022
Genomic Clones ( 1 )
	BACR03J17 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 174 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE54849
Other clones	DPiM_RE54849 yak-em_eIF
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT09856 GH23177 GH26437 GM05059 GM08006 GM18225 GM23274 GM24922 LD19805 LD23244 LD23823 LP02092 LP03403 LP18983 LP20959 RE05835 RE06209 RE08644 RE11709 RE14093 RE18285 RE35694 RE38685 RE39675 RE42218 RE46670 RE50344 RE56671 RE65487 RH05460 RH06554 RH06555 RH07536 RH07766 RH18232 RH36075 RH40819 RH54487 RH61079 RH62528 RH66753 RH73575 SD13027 SD19993 SD20532 SD21430 SD23544
Other clones	1232 16976 28036 31041 33103 35022 51139 54426 55524 59312 63257 63265 66340 79591 104630 123393 125766 125991 148826 161419 167092 282024 562017 AI124295 bs01g05 bs82b04 CK01.32B.F11 CK01.55C.G6 CK01.59A.H11 CK01.90D.C6 CK01.100B.H2 Dmel_dig_007071_0682_0600 Dmel_dig_018853_0585_1926 Dmel_dig_019688_0587_3504 Dmel_dig_020677_0712_3378 Dmel_neb_004906_0901_0279 Dmel_neb_013349_0889_2570 Dmel_neb_013997_0903_2964 Dmel_neb_015552_0449_1047 EC13168 EC25586 EK044859 EK047924 EK071143 EK084846 EK105009 EK116508 EK122337 EK128619 EK135526 EK140117 EK145315 EK158818 EK163609 EK179252 EK182158 EK189221 EK189237 EK193760 EK229345 EK244106 EK246210 EK255032 EK265317 EK279206 EK307330 EN13546 EN16840 ESG013b.E21_F09 ESG0114a.B21_H04 ESG0116a.B21_F09 FGC015H11 FGC017E06 FGM231E02 RC0-DA0001-130700-116-H01 RC0-DA0001-130700-120-F01 RC0-DL0001-140700-015-F06 RP004002328 RP004013518 RP004066090 RP004136396 RP004143871 RP004148007 RP004162205 RP004166827 RP004170337 RP004180444 RP004190502 RP004201511 RP004203071 RP004203782 RP004204445 RP004204905 RP004208256 RP004209942 RP004211446 RP004211844 RP004225364 RP004228806 RP004229253 RP004234862 RP004245522 RP004256162 RP004264155 RP004266154 RP004268670 RP004300098 RP004307425 RP004333570 RP004341811 RP004355560 RP004359554 RP004364333 RP004430071 RP004433577 RP004449864 RP004470135 RP004479031 RP004480270 RP004485197 RP004500218 RP004510471 RP004512048 RP004533990
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0026250 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 44260
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: eIF-1A anon-EST:Liang-2.3 (Myrick and Dearolf, 2000) Source for identity of: eIF1A CG8053 (FlyBase, 1996-)
Source for database merge of	Source for merge of: eIF-1A anon-EST:Posey4 (Bayraktaroglu, 2000.11.2) Source for merge of: eIF-1A EP935 (FlyBase, 1996-) Source for merge of: eIF-4A anon-EST:Liang-2.3 (Dearolf, 2000.3.3)
Additional comments	Source for identity of eIF1A CG8053 was sequence comparison (date:000327). (FlyBase, 1996-) Source for merge of eIF-1A EP935 was that EP935 insertion is within eIF-1A (and in the right orientation) (date:040519). (FlyBase, 1996-)
Other Comments
	RNAi screen using dsRNA made from templates generated with primers directed against this gene results in aberrantly short, monopolar spindles when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA. (Goshima et al., 2007) S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells. (Stroschein-Stevenson et al., 2006) Identification: in a subtractive hybridisation screen for genes that are transcriptionally activated by hop. (Myrick and Dearolf, 2000)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079989 NM_206509 RefSeq (Proteins) • NP_524728 NP_996231 DDBJ / EMBL / GenBank • AAF44294 AAF55526 AAM29503 AAS65169 AF083296 AF169359 AI124295 AI258809 AI944468 AQ025290 AQ073936 AQ254678 AY113498 BI368809 CL527770 CZ469329 Entrez Gene - A searchable database of RefSeq genes. • 44260 UniProtKB/TrEMBL • Q9NJB4 Q9VEA1
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Translation initiation factor 1A (eIF-1A), conserved site (IPR018104) Translation initiation factor 1A (eIF-1A) (IPR001253) RNA-binding domain, S1, IF1 type (IPR006196) Nucleic acid-binding, OB-fold (IPR012340) Nucleic acid-binding, OB-fold-like (IPR016027)
Linkouts
	BioGRID - A database of protein and genetic interactions • 68927 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0026250 DroID - A comprehensive database of gene and protein interactions. • FBgn0026250 DRSC - Results from RNAi screens. • FBgn0026250 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0026250 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8053-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0026250 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 44260 InParanoid A subset of ortholog calls from InParanoid. • AAEL004378-PA Aedes aegypti (mosquito) AGAP003119-PA Anopheles gambiae (mosquito) XP_001120011.1 Apis mellifera (honey bee) XP_001949715.1 Acyrthosiphon pisum (pea aphid) XP_001951024.1 Acyrthosiphon pisum (pea aphid) At2g04520.1 Arabidopsis thaliana (wall cress) At5g35680.1 Arabidopsis thaliana (wall cress) 6504 Batrachochytrium dendrobatidis (chytrid fungus) BGIBMGA006840-PA Bombyx mori (silk worm) ENSBTAP00000023455 Bos taurus (bovine) CAL0004326 Candida albicans (a form of yeast) CN25795 Caenorhabditis brenneri (small nematode) CBP02836 Caenorhabditis briggsae (nematode) CE17962 Caenorhabditis elegans (worm) ENSCAFP00000019328 Canis familiaris (dog) CAGL0H02409g Candida glabrata (haploid yeast) Chro.80386 Cryptosporidium hominis (obligate parasite) ENSCINP00000012866 Ciona intestinalis (sea squirt) JA12696 Caenorhabditis japonica (nematode) CMQ117C Cyanidioschyzon merolae (red alga) cn12114 Cryptococcus neoformans (yeast-like fungus) cgd8_3330 Cryptosporidium parvum (protozoan parasite) CPIJ016188 Culex pipens (mosquito) CPIJ019653 Culex pipens (mosquito) ENSCPOP00000019112 Cavia porcellus (guinea pig) 141865 Chlamidomonas reinhardtii (green alga) ENSCSAVP00000008325 Ciona savignyi (sedentary tunicate) 226988 Capitella spl (polychaete worm) DDB0234174 Dictyostelium discoideum (amoeba) DEHA2F06666g Debaryomyces Hansenii (yeast) 307936 Daphnia pulex (daphnia) ENSDARP00000066644 Danio rerio (zebra fish) ENSDARP00000075117 Danio rerio (zebra fish) ENSECAP00000004767 Equus caballus (horse) XP_652433 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000016987 Gymnopilus aculeatus (mushroom) ENSGALP00000026418 Gallus gallus (chicken) GL50803_8708 Giardia lamblia (flagellated protozoan) 84675 Hypsipyla robusta (cedar shoot borer) ENSP00000354722 Homo sapiens (human) ENSP00000368927 Homo sapiens (human) ISCW008220-PA Ixodes scapularis (deer tick) KLLA0E11287g Kluyveromyces lactis (yeast) 131336 Lottia gigantea (owl limpet) LmjF16.0140 Leishmania major (virus) 38832 Monocosta brevicollis (choanoflagellate) ENSMODP00000010076 Monodelphis domestica (gray opossum) ENSMMUP00000000270 Macaca mulatta (rhesus monkey) ENSMUSP00000077223 Mus musculus (house mouse) ENSMUSP00000084387 Mus musculus (house mouse) 193909 Nematostella vectensis (starlet anemone) XP_001606993.1 Nasonia vitripennis (wasp) ENSOANP00000021584 Ornithorynchus anatinus (platypus) ENSORLP00000003034 Oryzias latipes (japanese killifish) LOC_Os06g23440.1 Oryza sativa (asian rice) 7313 Ostreococcus tauri (green alga) PF11_0447 Plasmodium falciparum (protozoal parasite) PHUM004160-PA Pediculus humanus (human body louse) PP21862 Pristionchus pacificus (nematode) 158714 Physcomitrella patens (moss) 65162 Physcomitrella patens (moss) ENSPPYP00000022574 Pongo pygmaeus (orangutan) 71102 Phytophthora ramorum (sudden oak death pathogen) 156275 Phytophthora sojae (root rot pathogen) 645034 Populus trichocarpa (black cottonwood) 732377 Populus trichocarpa (black cottonwood) ENSPTRP00000038797 Pan troglodytes (chimpanzee) PVX_092775 Plasmodium vivax (protozoal parasite) ENSRNOP00000046345 Rattus norvegicus (norway rat) 148576 Sorghum bicolor (sorghum) YMR260C Saccharomyces cerevisiae (budding yeast) Smp_024880.1 Schistosoma mansoni (trematode parasite) SPBC25H2.07 Schizosaccharomyces pombe (fission yeast) XP_001196085.1 Strongylocentrotus purpuratus (purple sea urchin) 50975 Trichoplax adhaerens (metazoa) TA14970 Theileria annulata (apicomplexan parasite) XP_967161.1 Tribolium castaneum (red flour beetle) Tc00.1047053506743.4 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000007207 Tetraodon nigroviridis (green spotted pufferfish) TP02_0767 Theileria parva (parasitic protozoan) 595 Thalassiosira pseudonana (marine diatom) ENSTRUP00000017233 Takifugu rubripes (pufferfish Takifugu) 3715.m00109 Tetrahymena thermophila (ciliate protozoa) 81202.m00108 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000054137 Xenopus tropicalis (frog) YALI0F21153g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 44260 modMine - Data generated by the modENCODE project. • FBgn0026250 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV14671 LH17904 ISCW008220 FBgn0067983 FBgn0224371 FBgn0211630 FBgn0190728 FBgn0170216 JGI_V11_307936 FBgn0080782 FBgn0159297 FBgn0147206 FBgn0129857 FBgn0114986 FBgn0100072 CPIJ016188 CPIJ019653 BGIBMGA006840 ACYPI003855 ACYPI003565 GB13540 AGAP003119 AAEL004378 PB24200 PHUM134070 GLEAN_03838
Synonyms & Secondary IDs ( 15 )
Reported As
Symbol Synonym	anon-EST:Liang-2.3 (Biggin, 1999.2.5, ) anon-EST:Posey4   CG8053 (Lasko, 2000, Goshima et al., 2007, Keleman et al., 2009.8.5, Perkins et al., 2009, Ni et al., 2008, Ling and Salvaterra, 2011) clone 2.3 (Liang and Biggin, 1998) D-eIF1A (Myrick and Dearolf, 2000, Myrick and Dearolf, 2000) D-eIF4c (Myrick and Dearolf, 1999) eIF1A (Collins, 2005.7.7, Collins, 2005, Lasko, 2000, ) eIF-1A (Stroschein-Stevenson et al., 2006, Goshima et al., 2007, Karsten et al., 2006, Wang et al., 2008, Ling and Salvaterra, 2011) eIF-4c (Dearolf, 1999.3.5, ) EP935   EP(3)0935 (Pena-Rangel et al., 2002) group I (Collins, 2005.7.7) Group I (Collins, 2005)
Name Synonym	Eukaryotic initiation factor 1A (Myrick and Dearolf, 2000, Ling and Salvaterra, 2011) Eukaryotic initiation factor 4c (Myrick and Dearolf, 1999)
Secondary FlyBase IDs
	FBgn0025531 FBgn0025959 FBgn0038594 FBgn0062638
References ( 38 )
Generate a list of	All references relating to this gene ( 38 )
List References by type	Research paper  ( 10 ) Supplementary material  ( 4 ) Personal communication to FlyBase  ( 15 ) Abstract  ( 2 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 1 ) Computer file  ( 3 ) Curated genome annotation  ( 1 )
Recent research papers ( 1 )
	Ling and Salvaterra, 2011, PLoS ONE 6(3): e17762 Robust RT-qPCR Data Normalization: Validation and Selection of Internal Reference Genes during Post-Experimental Data Analysis. [FBrf0213272] Show all research papers ...