FB2020_06, released Dec 22, 2020

Gene: Dmel\msk

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General Information
Symbol
Dmel\msk
Species
D. melanogaster
Name
moleskin
Annotation Symbol
CG7935
Feature Type
protein_coding_gene
FlyBase ID
FBgn0026252
Gene Model Status
Current
Stock Availability
11 publicly available
Gene Snapshot
moleskin (msk) encodes an importin that contributes to protein import into the nucleus. It is involved in eye development, muscle attachment and wing cell fate specification. [Date last reviewed: 2019-09-26]
Other Summaries
Also Known As

DIM-7, CIP-61, Corkscrew Interacting Protein-61, Imp7, Dim7

Key Links
Genomic Location
Cytogenetic map
66B6-66B6
Sequence location
3L:8,116,179..8,121,579 [+]
Recombination map

3-22

RefSeq locus
NT_037436 REGION:8116179..8121579
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (26 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
enables protein binding
inferred from physical interaction with FLYBASE:Ced-12; FB:FBgn0032409
(Liu et al., 2013)
inferred from physical interaction with UniProtKB:Q9Y091
(assigned by UniProt )
(Ortega et al., 2003)
enables U1 snRNA binding
inferred from direct assay
(Natalizio and Matera, 2013)
enables U2 snRNA binding
inferred from direct assay
(Natalizio and Matera, 2013)
enables U4 snRNA binding
inferred from direct assay
(Natalizio and Matera, 2013)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables Ran GTPase binding
inferred from electronic annotation with InterPro:IPR001494
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Biological Process (13 terms)
Terms Based on Experimental Evidence (13 terms)
CV Term
Evidence
References
involved_in Cajal body organization
inferred from mutant phenotype
(Natalizio and Matera, 2013)
involved_in compound eye cone cell differentiation
inferred from mutant phenotype
(Pepple et al., 2007)
involved_in compound eye development
inferred from mutant phenotype
(Pepple et al., 2007)
inferred from genetic interaction with FLYBASE:sens; FB:FBgn0002573
(Pepple et al., 2007)
involved_in imaginal disc-derived wing morphogenesis
inferred from mutant phenotype
(Marenda et al., 2006)
involved_in imaginal disc-derived wing vein morphogenesis
inferred from mutant phenotype
(Marenda et al., 2006)
involved_in imaginal disc-derived wing vein specification
inferred from mutant phenotype
(Marenda et al., 2006)
involved_in muscle attachment
inferred from mutant phenotype
(Liu et al., 2013)
inferred from genetic interaction with FLYBASE:mbc; FB:FBgn0015513
(Liu et al., 2013)
inferred from genetic interaction with FLYBASE:Ced-12; FB:FBgn0032409
(Liu et al., 2013)
involved_in negative regulation of neuron apoptotic process
inferred from mutant phenotype
(Vrailas et al., 2006)
involved_in ommatidial rotation
inferred from mutant phenotype
(Vrailas et al., 2006)
involved_in protein import into nucleus
inferred from mutant phenotype
(Natalizio and Matera, 2013, Marenda et al., 2006)
inferred from direct assay
(Lorenzen et al., 2001)
involved_in R8 cell differentiation
inferred from mutant phenotype
(Pepple et al., 2007)
involved_in rhabdomere development
inferred from mutant phenotype
(Pepple et al., 2007)
involved_in wing cell fate specification
inferred from mutant phenotype
(Marenda et al., 2006)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in protein import into nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000108134
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (8 terms)
Terms Based on Experimental Evidence (7 terms)
CV Term
Evidence
References
located_in Cajal body
inferred from direct assay
(Natalizio and Matera, 2013)
located_in cell cortex
inferred from direct assay
(James et al., 2007, Lorenzen et al., 2001)
located_in cytoplasm
inferred from direct assay
(Natalizio and Matera, 2013)
located_in cytosol
inferred from high throughput direct assay
(Lye et al., 2014)
inferred from direct assay
(Lorenzen et al., 2001)
located_in nucleoplasm
inferred from high throughput direct assay
(Lye et al., 2014)
located_in nucleus
inferred from direct assay
(Lorenzen et al., 2001)
located_in perinuclear region of cytoplasm
inferred from direct assay
(James et al., 2007)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
located_in cytosol
inferred from biological aspect of ancestor with PANTHER:PTN000108134
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in nuclear envelope
inferred from biological aspect of ancestor with PANTHER:PTN000108134
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
BETA IMPORTINS -
Importin-β family proteins are nucleocytoplasmic transport receptors that import and export proteins and RNAs through the nuclear pores. In some import/export pathways, importin-β directly interacts with the cargo. For cargo containing a classical nuclear localization (cNLS) signal, importin-α acts as an adaptor linking the cargo to importin-β. (Adapted from FBrf0235243, FBrf0131350 and PMID:21029754).
Summary (Interactive Fly)

Importin 7 - functions in nuclear transport of MAPK - surface receptor signaling regulates MAPK localization through the adaptor protein Corkscrew

Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\msk for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Sequence Ontology: Class of Gene
gene_with_edited_transcript
(Graveley et al., 2011)
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
msk-RA
FBtr0076685
NM_080041
3979
1049
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
msk-PA
FBpp0076408
119.3
1049
4.48
NP_524780
AAF50487
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\msk using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism | posterior

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
primordial germ cell
(Fisher et al., 2012)
pole plasm
(Fisher et al., 2012)
embryonic stage 7 -- 8
head mesoderm
(Fisher et al., 2012)
hindgut anlage
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
primordial germ cell
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
embryonic stage 9 -- 10
anterior endoderm
(Fisher et al., 2012)
germline cell
(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
inclusive hindgut primordium
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 11 -- 12
anterior midgut primordium
(Fisher et al., 2012)
central brain primordium
(Fisher et al., 2012)
dorsal pharyngeal muscle primordium
(Fisher et al., 2012)
foregut primordium
(Fisher et al., 2012)
germline cell
(Fisher et al., 2012)
hindgut proper primordium
(Fisher et al., 2012)
posterior midgut primordium
(Fisher et al., 2012)
somatic muscle primordium

Comment: reported as muscle system primordium

(Fisher et al., 2012)
visceral muscle primordium

Comment: reported as muscle system primordium

(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
dorsal pharyngeal muscle
(Fisher et al., 2012)
embryonic brain
(Fisher et al., 2012)
embryonic hindgut
(Fisher et al., 2012)
embryonic/larval midgut
(Fisher et al., 2012)
embryonic/larval muscle system
(Fisher et al., 2012)
embryonic/larval somatic muscle
(Fisher et al., 2012)
embryonic/larval visceral muscle
(Fisher et al., 2012)
ventral nerve cord
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage | female
egg chamber
(Natalizio and Matera, 2013)
nurse cell
(Natalizio and Matera, 2013)
larval stage -- adult stage
Malpighian tubule
(Natalizio and Matera, 2013)
embryonic stage 15 -- late third instar larval stage
muscle attachment site
(Liu et al., 2013)
larval stage
embryonic/larval hypodermal muscle
• Z disc
(Liu et al., 2013)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
day 5 of adulthood & male -- day 7 of adulthood & male
spermatozoon
(Wasbrough et al., 2010)
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data

msk protein is found in close proximity to Ced-12 protein at muscle attachment sites.

(Liu et al., 2013)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in Cajal body
inferred from direct assay
(Natalizio and Matera, 2013)
located_in cell cortex
inferred from direct assay
(James et al., 2007, Lorenzen et al., 2001)
located_in cytoplasm
inferred from direct assay
(Natalizio and Matera, 2013)
located_in cytosol
inferred from high throughput direct assay
(Lye et al., 2014)
inferred from direct assay
(Lorenzen et al., 2001)
located_in nucleoplasm
inferred from high throughput direct assay
(Lye et al., 2014)
located_in nucleus
inferred from direct assay
(Lorenzen et al., 2001)
located_in perinuclear region of cytoplasm
inferred from direct assay
(James et al., 2007)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\msk in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 9 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 11 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of msk
Transgenic constructs containing regulatory region of msk
Deletions and Duplications ( 5 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal | embryonic stage | recessive
lethal | larval stage | recessive
lethal | recessive
lethal - all die before end of pupal stage | recessive
lethal - all die during P-stage, with Scer\GAL4Mef2.PR
lethal - all die during pupal stage, with Scer\GAL4Mef2.PR
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
cell death defective | larval stage | somatic clone
eye color defective | heat sensitive, with Scer\GAL4GMR.PF
increased cell death, with Scer\GAL4en-e16E
increased cell death | larval stage, with Scer\GAL4en-e16E
increased occurrence of cell division | larval stage, with Scer\GAL4en-e16E
mitotic cell cycle defective, with Scer\GAL4en-e16E
size defective | larval stage, with Scer\GAL4en-e16E
some die during pupal stage | recessive
visible, with Scer\GAL4en-e16E
visible, with Scer\GAL4pnr-MD237
visible | recessive | somatic clone
Phenotype manifest in
Allele
anterior crossvein, with Scer\GAL4en-e16E
chaeta, with Scer\GAL4pnr-MD237
cone cell | somatic clone
crossvein, with Scer\GAL4en-e16E
eye | heat sensitive, with Scer\GAL4GMR.PF
eye | somatic clone
eye photoreceptor cell | heat sensitive, with Scer\GAL4GMR.PF
interommatidial bristle | somatic clone
ommatidial precursor cluster | larval stage | somatic clone
ommatidium | somatic clone
photoreceptor cell R4 | larval stage | somatic clone
pigment cell | heat sensitive, with Scer\GAL4GMR.PF
posterior crossvein, with Scer\GAL4en-e16E
primary pigment cell | somatic clone
rhabdomere | somatic clone
rhabdomere R7 | somatic clone
rhabdomere R8 | somatic clone
secondary pigment cell | somatic clone
tertiary pigment cell | somatic clone
trichogen cell, with Scer\GAL4pnr-MD237
visceral muscle fiber | embryonic stage
visceral muscle fiber | embryonic stage, with Scer\GAL4Mef2.PR
visceral muscle fiber | embryonic stage, with Scer\GAL4twi.PU
visceral muscle fiber | embryonic stage (with msk4)
visceral muscle fiber | embryonic stage (with msk5)
visceral muscle fiber | third instar larval stage
wing, with Scer\GAL4en-e16E
wing disc posterior compartment | larval stage, with Scer\GAL4en-e16E
wing vein L4, with Scer\GAL4en-e16E
wing vein L5, with Scer\GAL4en-e16E
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (6)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\IPO7
14 of 15
Yes
Yes
Hsap\IPO8
13 of 15
No
Yes
Hsap\DDX60
1 of 15
No
Yes
Hsap\DDX60L
1 of 15
No
Yes
Hsap\MTREX
1 of 15
No
No
Hsap\SKIV2L
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (5)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Ipo7
15 of 15
Yes
Yes
Mmus\Ipo8
11 of 15
No
Yes
Mmus\Ddx60
1 of 15
No
Yes
Mmus\Mtrex
1 of 15
No
No
Mmus\Skiv2l
1 of 15
No
No
Rattus norvegicus (Norway rat) (4)
Rnor\Ipo7
13 of 13
Yes
Yes
Rnor\LOC686774
2 of 13
No
Yes
Rnor\Mtrex
1 of 13
No
No
Rnor\Skiv2l
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (4)
Xtro\ipo7
9 of 12
Yes
Yes
Xtro\ipo8
7 of 12
No
Yes
Xtro\LOC101733389
2 of 12
No
Yes
Xtro\skiv2l
1 of 12
No
No
Danio rerio (Zebrafish) (4)
Drer\ipo7
14 of 15
Yes
Yes
Drer\ipo8
7 of 15
No
Yes
Drer\mtrex
1 of 15
No
No
Drer\skiv2l
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (3)
Cele\C28H8.3
1 of 15
Yes
Yes
Cele\mtr-4
1 of 15
Yes
No
Cele\skih-2
1 of 15
Yes
No
Arabidopsis thaliana (thale-cress) (3)
Atha\AT3G59020
8 of 9
Yes
Yes
Atha\SAD2
8 of 9
Yes
Yes
Atha\AT3G17340
1 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (4)
Scer\NMD5
13 of 15
Yes
Yes
Scer\SXM1
5 of 15
No
Yes
Scer\MTR4
1 of 15
No
No
Scer\SKI2
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\SPCC550.11
11 of 12
Yes
Yes
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091901H4 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00003689
Drosophila simulans
Dsim\GD14053
Drosophila sechellia
Dsec\GM25020
Drosophila erecta
Dere\GG14470
Drosophila yakuba
Dyak\GE21658
Drosophila ananassae
Dana\GF23958
Drosophila pseudoobscura pseudoobscura
Dpse\GA20700
Drosophila persimilis
Dper\GL22608
Drosophila willistoni
Dwil\GK19967
Drosophila virilis
Dvir\GJ12092
Drosophila mojavensis
Dmoj\GI13322
Drosophila grimshawi
Dgri\GH16170
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500Z7 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17022812
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_01156
Mayetiola destructor
Hessian fly
Mdes\Mdes002829
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL009080
Anopheles darlingi
American malaria mosquito
Adar\ADAC002422
Anopheles gambiae
Malaria mosquito
Agam\AGAP007299
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ002096
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W010Z )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA002012
Bombyx mori
Silkmoth
Bmor\BGIBMGA002013
Danaus plexippus
Monarch butterfly
Dple\DPOGS203904-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL017931
Apis florea
Little honeybee
Aflo\2287095524
Apis mellifera
Western honey bee
Amel\GB48949
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP13446
Bombus terrestris
Buff-tailed bumblebee
Bter\15204541
Linepithema humile
Argentine ant
Lhum\LH10580
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001543
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG016439
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_07812
Tribolium castaneum
Red flour beetle
Tcas\TC003212
Pediculus humanus
Human body louse
Phum\PHUM581730
Rhodnius prolixus
Kissing bug
Rpro\RPRC001457
Rhodnius prolixus
Kissing bug
Rpro\RPRC001458
Cimex lectularius
Bed bug
Clec\CLEC001154
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI004006
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_03207
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X00Z6 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR007245
Ixodes scapularis
Black-legged tick
Isca\ISCW000557
Stegodyphus mimosarum
African social velvet spider
Smim\KFM76182.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur03g06550
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G01IF )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Ipo7-2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Ipo7
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_023271gn
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000008592
Gallus gallus
Domestic chicken
Ggal\IPO7
Gallus gallus
Domestic chicken
Ggal\IPO8
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (5)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Cse1
2 of 10
Impβ11
2 of 10
Ranbp9
2 of 10
Mtr4
1 of 10
tst
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    IPO7; importin 7
    14 of 15
    605586
        IPO8; importin 8
        13 of 15
        605600
            Functional Complementation Data
            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
            Interactions
            Summary of Physical Interactions
            esyN Network Diagram
            Show neighbor-neighbor interactions:
            Select Layout:
            Legend:
            Protein
            RNA
            Selected Interactor(s)
            Interactions Browser
            View in Interactions Browser
            Please see the Physical Interaction reports below for full details
            protein-protein
            Physical Interaction
            Assay
            References
            msk - Acsl
            experimental knowledge based
            (Guruharsha et al., 2011)
            msk - CG10417
            experimental knowledge based
            (Guruharsha et al., 2011)
            msk - CG12769
            anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
            (Rhee et al., 2014)
            msk - Cand1
            experimental knowledge based
            (Guruharsha et al., 2011)
            msk - Ced-12
            anti bait coimmunoprecipitation, western blot, pull down, anti tag western blot, proximity ligation assay, tag visualisation
            (Liu et al., 2013)
            msk - GluProRS
            experimental knowledge based
            (Guruharsha et al., 2011)
            msk - MRP
            experimental knowledge based
            (Guruharsha et al., 2011)
            msk - Mad
            anti tag coimmunoprecipitation, anti tag western blot, western blot
            (Chen and Xu, 2010, Xu et al., 2007)
            msk - Mpcp2
            experimental knowledge based
            (Guruharsha et al., 2011)
            msk - Pten
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            msk - Ranbp9
            experimental knowledge based
            (Guruharsha et al., 2011)
            msk - Sec13
            anti tag coimmunoprecipitation, anti tag western blot, pull down, western blot
            (Chen and Xu, 2010)
            msk - Sec63
            experimental knowledge based
            (Guruharsha et al., 2011)
            msk - SmB
            anti tag coimmunoprecipitation, western blot
            (Natalizio and Matera, 2013)
            msk - Smn
            anti tag coimmunoprecipitation, western blot
            (Natalizio and Matera, 2013)
            msk - Snup
            anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation
            (Natalizio and Matera, 2013)
            msk - csw
            anti bait coimmunoprecipitation, western blot, two hybrid, pull down
            (Lorenzen et al., 2001)
            msk - gig
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            msk - rictor
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            msk - rl
            anti bait coimmunoprecipitation, western blot
            (Lorenzen et al., 2001)
            RNA-protein
            Physical Interaction
            Assay
            References
            msk - snRNA:U1:21D
            anti tag coimmunoprecipitation, northern blot
            (Natalizio and Matera, 2013)
            msk - snRNA:U1:82Eb
            anti tag coimmunoprecipitation, northern blot
            (Natalizio and Matera, 2013)
            msk - snRNA:U1:95Ca
            anti tag coimmunoprecipitation, northern blot
            (Natalizio and Matera, 2013)
            msk - snRNA:U1:95Cb
            anti tag coimmunoprecipitation, northern blot
            (Natalizio and Matera, 2013)
            msk - snRNA:U1:95Cc
            anti tag coimmunoprecipitation, northern blot
            (Natalizio and Matera, 2013)
            msk - snRNA:U2:14B
            anti tag coimmunoprecipitation, northern blot
            (Natalizio and Matera, 2013)
            msk - snRNA:U2:34ABa
            anti tag coimmunoprecipitation, northern blot
            (Natalizio and Matera, 2013)
            msk - snRNA:U2:34ABb
            anti tag coimmunoprecipitation, northern blot
            (Natalizio and Matera, 2013)
            msk - snRNA:U2:34ABc
            anti tag coimmunoprecipitation, northern blot
            (Natalizio and Matera, 2013)
            msk - snRNA:U2:38ABa
            anti tag coimmunoprecipitation, northern blot
            (Natalizio and Matera, 2013)
            msk - snRNA:U2:38ABb
            anti tag coimmunoprecipitation, northern blot
            (Natalizio and Matera, 2013)
            msk - snRNA:U4:25F
            anti tag coimmunoprecipitation, northern blot
            (Natalizio and Matera, 2013)
            msk - snRNA:U4:38AB
            anti tag coimmunoprecipitation, northern blot
            (Natalizio and Matera, 2013)
            msk - snRNA:U4:39B
            anti tag coimmunoprecipitation, northern blot
            (Natalizio and Matera, 2013)
            Summary of Genetic Interactions
            esyN Network Diagram
            esyN Network Key:
            Suppression
            Enhancement
            View in Interactions Browser
            Please look at the allele data for full details of the genetic interactions
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            msk
            suppressible
            Ced-12
            (Liu et al., 2013)
            msk
            enhanceable
            Ced-12
            (Liu et al., 2013)
            msk
            suppressible
            Ced-12|mbc
            (Liu et al., 2013)
            msk
            enhanceable
            mbc
            (Liu et al., 2013)
            msk
            suppressible
            mbc
            (Liu et al., 2013)
            msk
            suppressible
            Rac1
            (Liu et al., 2013)
            msk
            suppressible
            rl
            (Marenda et al., 2006)
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            aos
            enhanceable
            msk
            (Marenda et al., 2006)
            Ced-12
            enhanceable
            msk
            (Liu et al., 2013)
            csw
            suppressible
            msk
            (Johnson Hamlet and Perkins, 2001)
            Dg
            enhanceable
            msk
            (Kucherenko et al., 2008)
            Dys
            enhanceable
            msk
            (Kucherenko et al., 2008)
            Dys
            suppressible
            msk
            (Kucherenko et al., 2008)
            if
            suppressible
            msk
            (Baker et al., 2002)
            rho
            enhanceable
            msk
            (Marenda et al., 2006, Baker et al., 2002)
            rho
            suppressible
            msk
            (Marenda et al., 2006)
            rl
            suppressible
            msk
            (Lorenzen et al., 2001)
            rl
            enhanceable
            msk
            (Lorenzen et al., 2001)
            sens
            suppressible
            msk
            (Pepple et al., 2007)
            External Data
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            DroID - A comprehensive database of gene and protein interactions.
            InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
            MIST (genetic) - An integrated Molecular Interaction Database
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Pathways
            Signaling Pathways (FlyBase)
            Metabolic Pathways
            External Data
            Linkouts
            KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
            Genomic Location and Detailed Mapping Data
            Chromosome (arm)
            3L
            Recombination map

            3-22

            Cytogenetic map
            66B6-66B6
            Sequence location
            3L:8,116,179..8,121,579 [+]
            FlyBase Computed Cytological Location
            Cytogenetic map
            Evidence for location
            66B6-66B6
            Limits computationally determined from genome sequence between P{PZ}l(3)0721708223&P{EP}Rac2EP3118 and P{lacW}Nmtj1C7
            Experimentally Determined Cytological Location
            Cytogenetic map
            Notes
            References
            66B8-66B10
            (Lorenzen et al., 2001, Lorenzen, 1999.3.1, Lorenzen, 1999.3.4)
            Experimentally Determined Recombination Data
            Location

            3-22

            (FlyBase, 2016)

            3-19.0

            (Comeron et al., 2012)
            Left of (cM)
            Right of (cM)
            Notes
            Stocks and Reagents
            Stocks (11)
            Genomic Clones (18)
             

            Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

            cDNA Clones (73)
             

            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

            cDNA clones, fully sequenced
            BDGP DGC clones
            Other clones
            Drosophila Genomics Resource Center cDNA clones

            For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

            cDNA Clones, End Sequenced (ESTs)
            BDGP DGC clones
            Other clones
            RNAi and Array Information
            Linkouts
            DRSC - Results frm RNAi screens
            GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
            Antibody Information
            Laboratory Generated Antibodies
             

            polyclonal

            (Lorenzen et al., 2001)
            Commercially Available Antibodies
             
            Other Information
            Relationship to Other Genes
            Source for database identify of

            Source for identity of: msk dim-7

            (Lorenzen et al., 2001)
            Source for database merge of

            Source for merge of: dim-7 CG7935

            (Perkins, 2000.3.27, FlyBase, 1996-)

            Source for merge of: msk CIP-61

            (Perkins, 2001.9.13)
            Additional comments

            Source for merge of dim-7 CG7935 was sequence comparison ( date:000414 ).

            (FlyBase, 1996-)
            Other Comments

            In an EMS screen for dominant modifiers of the eye phenotype caused by expression of sensScer\UAS.cNa under the control of Scer\GAL4lz-gal4. 15 alleles of msk have been isolated in the screen.

            (Pepple et al., 2007)

            msk is involved in the nuclear transportation of rho.

            (Marenda et al., 2006)

            msk is required for cell proliferation and survival in phase 0 of eye development, as well as for correct ommatidial rotation (and not chirality) in phase 2.

            (Vrailas et al., 2006)

            msk is required for cell proliferation in the larval stage, and later for the survival of postmitotic cells.

            (Vrailas et al., 2006)

            msk is genetically downstream of the hh and dpp receptors in the eye furrow.

            (Vrailas et al., 2006)

            Identification: in a yeast two hybrid screen for interactors with csw protein.

            (Lorenzen et al., 2001)

            The msk protein interacts with the C-terminal domain of csw.

            (Lorenzen et al., 2001)

            Identification: Screen for proteins that bind csw protein.

            (Lorenzen et al., 1999)

            Identification: Yeast two hybrid screen for proteins that interact specifically with the carboxyl terminal region of the csw protein.

            (Lorenzen et al., 1998)

            msk encodes a phosphoprotein that interacts with both the csw and drk proteins.

            (Lorenzen et al., 1998)
            Origin and Etymology
            Discoverer
            Etymology

            Since this locus was identified as a suppressor of blistering, the gene has been named "moleskin".

            (Baker et al., 2002)

            Name "dim-7" denotes the strikingly DIMinished activated MAP kinase immunostaining observed in embryos mutant for Importin 7/RanBP7.

            (Lorenzen, 1999.3.4)
            Identification
            External Crossreferences and Linkouts ( 45 )
            Sequence Crossreferences
            NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
            GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
            GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
            RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
            UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
            Other crossreferences
            BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
            Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
            Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
            Flygut - An atlas of the Drosophila adult midgut
            GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
            iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
            InterPro - A database of protein families, domains and functional sites
            KEGG Genes - Molecular building blocks of life in the genomic space.
            modMine - A data warehouse for the modENCODE project
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            DroID - A comprehensive database of gene and protein interactions.
            DRSC - Results frm RNAi screens
            FLIGHT - Cell culture data for RNAi and other high-throughput technologies
            FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
            FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
            FlyMine - An integrated database for Drosophila genomics
            Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
            InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
            KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
            MIST (genetic) - An integrated Molecular Interaction Database
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
            Synonyms and Secondary IDs (21)
            Reported As
            Symbol Synonym
            61
            (Lorenzen et al., 1998)
            CG7935
            (Hosono et al., 2015, Christis and Munro, 2012, Ni et al., 2011.7.19, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Mason and Goldfarb, 2009, Perkins et al., 2009, Jin et al., 2001, Lippai et al., 2000, Perkins, 2000.3.27)
            CIP-61
            (Perkins, 2001.9.13, Lorenzen et al., 1998)
            DIM-7
            (Liu and Geisbrecht, 2011, James et al., 2007, Marenda, 2007, Han et al., 2004, Lorenzen et al., 2003, Lorenzen et al., 2001)
            Dim-7
            (Firth and Baker, 2003, Perkins, 2001.9.13)
            Dim7
            (Liu et al., 2013, Mason and Goldfarb, 2009)
            DmRanBP7
            (Lorenzen et al., 1999)
            Imp7
            (Gawlinski et al., 2007, Gawlinski et al., 2007)
            Imp7/8
            (Chen and Xu, 2010, Yao et al., 2008)
            Msk
            (Sopko et al., 2015, Kimura and Imamoto, 2014, Mbodj et al., 2013, Chen and Xu, 2010, Yao et al., 2008, Vrailas et al., 2006)
            S(ls)2
            (Pepple et al., 2007)
            dim-7
            (Pepple et al., 2007, Ortega et al., 2003, Lorenzen, 1999.3.4)
            dim7
            (Vrailas et al., 2005)
            msk
            (Sinha et al., 2019, Billmann et al., 2018, Vishal et al., 2017, Lee et al., 2016, Quijano et al., 2016, Jambor et al., 2015, Maartens and Brown, 2015, Bischof and FlyORF project members, 2014.6.20, Chen et al., 2014, Carter, 2013, Kwon et al., 2013, Liu et al., 2013, Natalizio and Matera, 2013, Chan et al., 2011, Friedman et al., 2011, Liu and Geisbrecht, 2011, Frise et al., 2010, Wasbrough et al., 2010, Kucherenko et al., 2008, James et al., 2007, Marenda, 2007, Peng et al., 2007, Vrailas-Mortimer et al., 2007, Xu et al., 2007, Loop et al., 2004)
            Name Synonyms
            Corkscrew Interacting Protein-61
            (Perkins, 2001.9.13, Lorenzen et al., 1998)
            Drosophila Importin-7
            (Liu et al., 2013)
            Importin-7
            (Liu and Geisbrecht, 2011)
            Moleskin
            (Kimura and Imamoto, 2014, Gawlinski et al., 2007, Gawlinski et al., 2007, Vrailas et al., 2006)
            diminished-7
            (Lorenzen, 1999.3.4)
            importin-7
            (James et al., 2007)
            moleskin
            (Hampoelz et al., 2019, Young and Marcotte, 2017, Maartens and Brown, 2015, Kimura and Imamoto, 2014, Liu et al., 2013, Liu and Geisbrecht, 2011, Mason and Goldfarb, 2009, James et al., 2007, Pepple et al., 2007, Vrailas-Mortimer et al., 2007, Xu et al., 2007, Han et al., 2004, Baker et al., 2002, Lorenzen et al., 2001, Perkins, 2001.9.13)
            Secondary FlyBase IDs
            • FBgn0024487
            • FBgn0035837
            Datasets (0)
            Study focus (0)
            Experimental Role
            Project
            Project Type
            Title
            References (103)