• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • CytoSearch
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Downloads:
  • Precomputed files
  • Archived data
  • Releases (FTP)
  • Genomes (FTP)
  • AAA data (FTP)
  • Lists:
  • Transposons (Dmel)
  • Transposons (other)
  • Vectors & Constructs
  • Anatomical Terms
  • Map Conversion
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Other links:
  • BDGP
  • DGRC
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\eIF5B

General Information
Symbol	Dmel\eIF5B	Species	D. melanogaster
Name	eIF5B	Annotation symbol	CG10840
Feature type	protein_coding_gene	FlyBase ID	FBgn0026259
Gene Model Status	Current	Stock availability	7 publicly available
Also Known As	cIF2, dIF2, IF2
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	63E1-63E1	Sequence location	3L:3,428,658..3,460,977 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene eIF5B is referred to in FlyBase by the symbol Dmel\eIF5B (CG10840, FBgn0026259). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: translation initiation factor activity. Based on sequence similarity, it is predicted to be involved in the biological process: translational initiation. 11 alleles are reported. No phenotypic data is available. It has 5 annotated transcripts and 5 annotated polypeptides. Protein features are: Protein synthesis factor, GTP-binding; Small GTP-binding protein domain; Translation elongation factor EFTu/EF1A, domain 2; Translation elongation/initiation factor/Ribosomal, beta-barrel; Translation initiation factor IF- 2; Translation initiation factor IF- 2, domain 3. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed within 00-06 hour embryonic stages, during early larval stages, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, larval/adult salivary gland, adult ovary, adult male reproductive system, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval trachea, adult spermathecae, adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1639716_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of eIF5B. Gene sequence location is 3L:3428658..3460977.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10	References Knowles-Barley, 2011.8.24, BrainTrap expression curation.
FB2012_01	Sequence features BKN24634 HFA08710 HFA08429
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 63E1-63E1   Limits computationally determined from genome sequence between P{PZ}kst01318 and P{PZ}Sc205634
Experimentally Determined Cytological Location
Cytogenetic map Notes References 63D-63D     (Carrera, 1999.4.14) 63D2-63D3     (Lasko, 1999.3.3)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\eIF5B for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.41
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) eIF5B-RB FBtr0073144  NM_143717   4073   1144 eIF5B-RC FBtr0309836     4362   1144 eIF5B-RD FBtr0309837     4248   1090 eIF5B-RE FBtr0309838     4277   1108 eIF5B-RF FBtr0309839     4481   1144
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein eIF5B-PB   FBpp0073003   127.2   1144   5.17     NP_651974   AAF47774 eIF5B-PC   FBpp0301570   127.2   1144   5.17       eIF5B-PD   FBpp0301571   121.1   1090   5.15       eIF5B-PE   FBpp0301572   123.3   1108   5.16       eIF5B-PF   FBpp0301573   127.2   1144   5.17
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Protein synthesis factor, GTP-binding (IPR000795) Translation elongation factor EFTu/EF1A, domain 2 (IPR004161) Small GTP-binding protein domain (IPR005225) Translation elongation/initiation factor/Ribosomal, beta-barrel (IPR009000) Translation initiation factor IF- 2 (IPR015760) Translation initiation factor IF- 2, domain 3 (IPR023115)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA803203   AE014296 AAF47774   AC004356   AF143207 AAF36532   AI257963   AI260108   AI516603   AI531403   AI542277   AX094238   BE975993   BE976026   BE977232   BF489050   BF490356   BF490670   BF493275   BF493718   BF494333   BF494415   BF494552   BF497157   BF497854   BF502987   BF504046   BF504127   BF506005   BF506080   BG634223   BG634864   BG636599   BG640674   BI161691   BI161692   BI165420   BI170274   BI354255   BI354314   BI354326   BI358654   BI358709   BI632371   BI632686   BP541625   BP544258   BP544259   BP549713   BP550771   BT023767   BZ286337   CK605469   CK605470   CL610102   CO153306   CO153928   CO154135   CO155100   CO285916   CO288641   CO298942   CO314167   CO338446   CO338475   CO338872   CO343583   CO345143   EC068849   EC081576   EC088262   EC205939   EC217551   EC218767   EC236821   EC261055   EC261873   EC263639   EC264599   EC266226   EC268057   EV594584   FE863467   FE863540   FE863741   FE863794   FE863856   G00521   GH739650   GH739698   GH740598   GH745226   GH745316   GH746406   GH765714
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9NJH7 Q9VZP5
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0026259    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0026259 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed within 00-06 hour embryonic stages, during early larval stages, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0026259 expression level Developmental Stage   Expression Level embryo 00-02hr    4507 embryo 02-04hr    1808 embryo 04-06hr    2836 embryo 06-08hr    3355 embryo 08-10hr    3484 embryo 10-12hr    3489 embryo 12-14hr    2993 embryo 14-16hr    2545 embryo 16-18hr    2380 embryo 18-20hr    2016 embryo 20-22hr    2807 embryo 22-24hr    2757 larva L1    4921 larva L2    4817 larva L3 12hr old    3800 larva L3 puffstage 1-2    1837 larva L3 puffstage 3-6    2655 larva L3 puffstage 7-9    2943 white prepupae new    3084 white prepupae 12hr    2718 white prepupae 24hr    3813 pupae 2d postWPP    3969 pupae 3d postWPP    3141 pupae 4d postWPP    2640 adult male 01day    4524 adult male 05day    5296 adult male 30day    4555 adult female 01day    4030 adult female 05day    5765 adult female 30day    5582 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4507) embryo 02-04hr  (1808) embryo 04-06hr  (2836) embryo 06-08hr  (3355) embryo 08-10hr  (3484) embryo 10-12hr  (3489) embryo 12-14hr  (2993) embryo 14-16hr  (2545) embryo 16-18hr  (2380) embryo 18-20hr  (2016) embryo 20-22hr  (2807) embryo 22-24hr  (2757) larva L1  (4921) larva L2  (4817) larva L3 12hr old  (3800) larva L3 puffstage 1-2  (1837) larva L3 puffstage 3-6  (2655) larva L3 puffstage 7-9  (2943) white prepupae new  (3084) white prepupae 12hr  (2718) white prepupae 24hr  (3813) pupae 2d postWPP  (3969) pupae 3d postWPP  (3141) pupae 4d postWPP  (2640) adult male 01day  (4524) adult male 05day  (5296) adult male 30day  (4555) adult female 01day  (4030) adult female 05day  (5765) adult female 30day  (5582) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4507) embryo 02-04hr  (1808) embryo 04-06hr  (2836) embryo 06-08hr  (3355) embryo 08-10hr  (3484) embryo 10-12hr  (3489) embryo 12-14hr  (2993) embryo 14-16hr  (2545) embryo 16-18hr  (2380) embryo 18-20hr  (2016) embryo 20-22hr  (2807) embryo 22-24hr  (2757) larva L1  (4921) larva L2  (4817) larva L3 12hr old  (3800) larva L3 puffstage 1-2  (1837) larva L3 puffstage 3-6  (2655) larva L3 puffstage 7-9  (2943) white prepupae new  (3084) white prepupae 12hr  (2718) white prepupae 24hr  (3813) pupae 2d postWPP  (3969) pupae 3d postWPP  (3141) pupae 4d postWPP  (2640) adult male 01day  (4524) adult male 05day  (5296) adult male 30day  (4555) adult female 01day  (4030) adult female 05day  (5765) adult female 30day  (5582) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4507 embryo 02-04hr    1808 embryo 04-06hr    2836 embryo 06-08hr    3355 embryo 08-10hr    3484 embryo 10-12hr    3489 embryo 12-14hr    2993 embryo 14-16hr    2545 embryo 16-18hr    2380 embryo 18-20hr    2016 embryo 20-22hr    2807 embryo 22-24hr    2757 larva L1    4921 larva L2    4817 larva L3 12hr old    3800 larva L3 puffstage 1-2    1837 larva L3 puffstage 3-6    2655 larva L3 puffstage 7-9    2943 white prepupae new    3084 white prepupae 12hr    2718 white prepupae 24hr    3813 pupae 2d postWPP    3969 pupae 3d postWPP    3141 pupae 4d postWPP    2640 adult male 01day    4524 adult male 05day    5296 adult male 30day    4555 adult female 01day    4030 adult female 05day    5765 adult female 30day    5582 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4507 embryo 02-04hr    1808 embryo 04-06hr    2836 embryo 06-08hr    3355 embryo 08-10hr    3484 embryo 10-12hr    3489 embryo 12-14hr    2993 embryo 14-16hr    2545 embryo 16-18hr    2380 embryo 18-20hr    2016 embryo 20-22hr    2807 embryo 22-24hr    2757 larva L1    4921 larva L2    4817 larva L3 12hr old    3800 larva L3 puffstage 1-2    1837 larva L3 puffstage 3-6    2655 larva L3 puffstage 7-9    2943 white prepupae new    3084 white prepupae 12hr    2718 white prepupae 24hr    3813 pupae 2d postWPP    3969 pupae 3d postWPP    3141 pupae 4d postWPP    2640 adult male 01day    4524 adult male 05day    5296 adult male 30day    4555 adult female 01day    4030 adult female 05day    5765 adult female 30day    5582 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0026259 expression level Developmental Stage   Expression Level embryo 00-02hr    4507 embryo 02-04hr    1808 embryo 04-06hr    2836 embryo 06-08hr    3355 embryo 08-10hr    3484 embryo 10-12hr    3489 embryo 12-14hr    2993 embryo 14-16hr    2545 embryo 16-18hr    2380 embryo 18-20hr    2016 embryo 20-22hr    2807 embryo 22-24hr    2757 larva L1    4921 larva L2    4817 larva L3 12hr old    3800 larva L3 puffstage 1-2    1837 larva L3 puffstage 3-6    2655 larva L3 puffstage 7-9    2943 white prepupae new    3084 white prepupae 12hr    2718 white prepupae 24hr    3813 pupae 2d postWPP    3969 pupae 3d postWPP    3141 pupae 4d postWPP    2640 adult male 01day    4524 adult male 05day    5296 adult male 30day    4555 adult female 01day    4030 adult female 05day    5765 adult female 30day    5582 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4507) embryo 02-04hr  (1808) embryo 04-06hr  (2836) embryo 06-08hr  (3355) embryo 08-10hr  (3484) embryo 10-12hr  (3489) embryo 12-14hr  (2993) embryo 14-16hr  (2545) embryo 16-18hr  (2380) embryo 18-20hr  (2016) embryo 20-22hr  (2807) embryo 22-24hr  (2757) larva L1  (4921) larva L2  (4817) larva L3 12hr old  (3800) larva L3 puffstage 1-2  (1837) larva L3 puffstage 3-6  (2655) larva L3 puffstage 7-9  (2943) white prepupae new  (3084) white prepupae 12hr  (2718) white prepupae 24hr  (3813) pupae 2d postWPP  (3969) pupae 3d postWPP  (3141) pupae 4d postWPP  (2640) adult male 01day  (4524) adult male 05day  (5296) adult male 30day  (4555) adult female 01day  (4030) adult female 05day  (5765) adult female 30day  (5582) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4507) embryo 02-04hr  1808 embryo 04-06hr  (2836) embryo 06-08hr  (3355) embryo 08-10hr  (3484) embryo 10-12hr  (3489) embryo 12-14hr  (2993) embryo 14-16hr  (2545) embryo 16-18hr  2380 embryo 18-20hr  2016 embryo 20-22hr  (2807) embryo 22-24hr  (2757) larva L1  (4921) larva L2  (4817) larva L3 12hr old  (3800) larva L3 puffstage 1-2  1837 larva L3 puffstage 3-6  (2655) larva L3 puffstage 7-9  (2943) white prepupae new  (3084) white prepupae 12hr  (2718) white prepupae 24hr  (3813) pupae 2d postWPP  (3969) pupae 3d postWPP  (3141) pupae 4d postWPP  (2640) adult male 01day  (4524) adult male 05day  (5296) adult male 30day  (4555) adult female 01day  (4030) adult female 05day  (5765) adult female 30day  (5582) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4507 embryo 02-04hr    1808 embryo 04-06hr    2836 embryo 06-08hr    3355 embryo 08-10hr    3484 embryo 10-12hr    3489 embryo 12-14hr    2993 embryo 14-16hr    2545 embryo 16-18hr    2380 embryo 18-20hr    2016 embryo 20-22hr    2807 embryo 22-24hr    2757 larva L1    4921 larva L2    4817 larva L3 12hr old    3800 larva L3 puffstage 1-2    1837 larva L3 puffstage 3-6    2655 larva L3 puffstage 7-9    2943 white prepupae new    3084 white prepupae 12hr    2718 white prepupae 24hr    3813 pupae 2d postWPP    3969 pupae 3d postWPP    3141 pupae 4d postWPP    2640 adult male 01day    4524 adult male 05day    5296 adult male 30day    4555 adult female 01day    4030 adult female 05day    5765 adult female 30day    5582 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4507 embryo 02-04hr    1808 embryo 04-06hr    2836 embryo 06-08hr    3355 embryo 08-10hr    3484 embryo 10-12hr    3489 embryo 12-14hr    2993 embryo 14-16hr    2545 embryo 16-18hr    2380 embryo 18-20hr    2016 embryo 20-22hr    2807 embryo 22-24hr    2757 larva L1    4921 larva L2    4817 larva L3 12hr old    3800 larva L3 puffstage 1-2    1837 larva L3 puffstage 3-6    2655 larva L3 puffstage 7-9    2943 white prepupae new    3084 white prepupae 12hr    2718 white prepupae 24hr    3813 pupae 2d postWPP    3969 pupae 3d postWPP    3141 pupae 4d postWPP    2640 adult male 01day    4524 adult male 05day    5296 adult male 30day    4555 adult female 01day    4030 adult female 05day    5765 adult female 30day    5582 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0026259    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0026259 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, larval/adult salivary gland, adult ovary, adult male reproductive system, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval trachea, adult spermathecae, adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0026259 expression level Tissue   Expression Level Larval Central Nervous System    505.55 Larval Midgut    360.1 Larval Hindgut    442.4 Larval Malpighian Tubules    402.8 Larval Fat Body    409 Larval Salivary Gland    884.7 Larval Trachea    419.925 Larval Carcass    640.5 Adult Head    263.1 Adult Eye    225.05 Adult Brain    294.5 Adult Thoracic-Abdominal Ganglion    342.6 Adult Crop    422.7 Adult Midgut    349.6 Adult Hindgut    283.4 Adult Malpighian Tubules    433.8 Adult Fat Body    356.3 Adult Salivary Gland    616.3 Adult Heart    231.625 Adult VirginFemale Spermatheca    391.6 Adult InseminatedFemale Spermatheca    458.7 Adult Ovary    533.2 Adult Testis    722.4 Adult Male Accessory Gland    572.2 Adult Carcass    323.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  505.55 Larval Midgut    360.1 Larval Hindgut    442.4 Larval Malpighian Tubules    402.8 Larval Fat Body    409 Larval Salivary Gland  (884.7) Larval Trachea    419.925 Larval Carcass  (640.5) Adult Head    263.1 Adult Eye    225.05 Adult Brain    294.5 Adult Thoracic-Abdominal Ganglion    342.6 Adult Crop    422.7 Adult Midgut    349.6 Adult Hindgut    283.4 Adult Malpighian Tubules    433.8 Adult Fat Body    356.3 Adult Salivary Gland  (616.3) Adult Heart    231.625 Adult VirginFemale Spermatheca    391.6 Adult InseminatedFemale Spermatheca    458.7 Adult Ovary  533.2 Adult Testis  (722.4) Adult Male Accessory Gland  (572.2) Adult Carcass    323.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    505.55 Larval Midgut    360.1 Larval Hindgut    442.4 Larval Malpighian Tubules    402.8 Larval Fat Body    409 Larval Salivary Gland    884.7 Larval Trachea    419.925 Larval Carcass    640.5 Adult Head    263.1 Adult Eye    225.05 Adult Brain    294.5 Adult Thoracic-Abdominal Ganglion    342.6 Adult Crop    422.7 Adult Midgut    349.6 Adult Hindgut    283.4 Adult Malpighian Tubules    433.8 Adult Fat Body    356.3 Adult Salivary Gland    616.3 Adult Heart    231.625 Adult VirginFemale Spermatheca    391.6 Adult InseminatedFemale Spermatheca    458.7 Adult Ovary    533.2 Adult Testis    722.4 Adult Male Accessory Gland    572.2 Adult Carcass    323.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    505.55 Larval Midgut    360.1 Larval Hindgut    442.4 Larval Malpighian Tubules    402.8 Larval Fat Body    409 Larval Salivary Gland    884.7 Larval Trachea    419.925 Larval Carcass    640.5 Adult Head    263.1 Adult Eye    225.05 Adult Brain    294.5 Adult Thoracic-Abdominal Ganglion    342.6 Adult Crop    422.7 Adult Midgut    349.6 Adult Hindgut    283.4 Adult Malpighian Tubules    433.8 Adult Fat Body    356.3 Adult Salivary Gland    616.3 Adult Heart    231.625 Adult VirginFemale Spermatheca    391.6 Adult InseminatedFemale Spermatheca    458.7 Adult Ovary    533.2 Adult Testis    722.4 Adult Male Accessory Gland    572.2 Adult Carcass    323.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0026259 expression level Tissue   Expression Level Larval Central Nervous System    505.55 Larval Midgut    360.1 Larval Hindgut    442.4 Larval Malpighian Tubules    402.8 Larval Fat Body    409 Larval Salivary Gland    884.7 Larval Trachea    419.925 Larval Carcass    640.5 Adult Head    263.1 Adult Eye    225.05 Adult Brain    294.5 Adult Thoracic-Abdominal Ganglion    342.6 Adult Crop    422.7 Adult Midgut    349.6 Adult Hindgut    283.4 Adult Malpighian Tubules    433.8 Adult Fat Body    356.3 Adult Salivary Gland    616.3 Adult Heart    231.625 Adult VirginFemale Spermatheca    391.6 Adult InseminatedFemale Spermatheca    458.7 Adult Ovary    533.2 Adult Testis    722.4 Adult Male Accessory Gland    572.2 Adult Carcass    323.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  505.55 Larval Midgut    360.1 Larval Hindgut    442.4 Larval Malpighian Tubules    402.8 Larval Fat Body    409 Larval Salivary Gland  (884.7) Larval Trachea    419.925 Larval Carcass  640.5 Adult Head    263.1 Adult Eye    225.05 Adult Brain    294.5 Adult Thoracic-Abdominal Ganglion    342.6 Adult Crop    422.7 Adult Midgut    349.6 Adult Hindgut    283.4 Adult Malpighian Tubules    433.8 Adult Fat Body    356.3 Adult Salivary Gland  616.3 Adult Heart    231.625 Adult VirginFemale Spermatheca    391.6 Adult InseminatedFemale Spermatheca    458.7 Adult Ovary  533.2 Adult Testis  722.4 Adult Male Accessory Gland  572.2 Adult Carcass    323.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    505.55 Larval Midgut    360.1 Larval Hindgut    442.4 Larval Malpighian Tubules    402.8 Larval Fat Body    409 Larval Salivary Gland    884.7 Larval Trachea    419.925 Larval Carcass    640.5 Adult Head    263.1 Adult Eye    225.05 Adult Brain    294.5 Adult Thoracic-Abdominal Ganglion    342.6 Adult Crop    422.7 Adult Midgut    349.6 Adult Hindgut    283.4 Adult Malpighian Tubules    433.8 Adult Fat Body    356.3 Adult Salivary Gland    616.3 Adult Heart    231.625 Adult VirginFemale Spermatheca    391.6 Adult InseminatedFemale Spermatheca    458.7 Adult Ovary    533.2 Adult Testis    722.4 Adult Male Accessory Gland    572.2 Adult Carcass    323.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    505.55 Larval Midgut    360.1 Larval Hindgut    442.4 Larval Malpighian Tubules    402.8 Larval Fat Body    409 Larval Salivary Gland    884.7 Larval Trachea    419.925 Larval Carcass    640.5 Adult Head    263.1 Adult Eye    225.05 Adult Brain    294.5 Adult Thoracic-Abdominal Ganglion    342.6 Adult Crop    422.7 Adult Midgut    349.6 Adult Hindgut    283.4 Adult Malpighian Tubules    433.8 Adult Fat Body    356.3 Adult Salivary Gland    616.3 Adult Heart    231.625 Adult VirginFemale Spermatheca    391.6 Adult InseminatedFemale Spermatheca    458.7 Adult Ovary    533.2 Adult Testis    722.4 Adult Male Accessory Gland    572.2 Adult Carcass    323.8 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    263.1   NA  Eye    225.05   NA  Brain    294.5   505.55  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    342.6   NA  Crop    422.7   360.1  Midgut    349.6   442.4  Hindgut    283.4   402.8  Malpighian Tubules    433.8   409  Fat Body    356.3   884.7  Salivary Gland    616.3   NA  Heart    231.625   419.925  Trachea    NA   NA  VirginFemale Spermatheca    391.6   NA  InseminatedFemale Spermatheca    458.7   NA  Ovary    533.2   NA  Testis    722.4   NA  Male Accessory Gland    572.2   640.5  Carcass    323.8 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_26
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0026259 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10840-RB
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4pnr-MD237 eIF5BGD7105 lethal | larval stage | recessive eIF5Bunspecified lethal | pupal stage, with Scer\GAL4pnr-MD237 eIF5BGD7105 lethal | recessive eIF5BΔ1 eIF5BΔ2 viable eIF5BEY01401 Sterility Allele fertile eIF5BEY01401 Phenotype manifest in Allele
Classical Alleles ( 9 )
For All Classical Alleles Show
Allele of eIF5B Class Mutagen Stocks Known lesion eIF5B09143 1 Yes eIF5Bc02932 1 -- eIF5BEY01401 P-element activity 1 -- eIF5BKG09489 P-element activity 1 -- eIF5BMI00125 1 -- eIF5BCPTI003501 piggyBac transposase 0 Yes eIF5Bunspecified 0 -- eIF5BΔ1 Delta2-3 0 Yes eIF5BΔ2 Delta2-3 0 Yes
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of eIF5B Class Mutagen Stocks Known lesion eIF5BGD7105 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes eIF5BKK105498 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)G5 (Carrera et al., 2000) Df(3L)HR119 (Carrera et al., 2000) Df(3L)HR232 (Carrera et al., 2000)
Not disrupted in	Df(3L)armiΔ1 (Olivieri et al., 2010)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD7105} NA P{KK105498} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}L3659 No P{PZ}eIF5B09143 No insertion of mobile activating element P{EPgy2}eIF5BEY01401 NA miscellaneous insertions Mi{MIC}eIF5BMI00125 NA P{?lacW}eIF5BΔ1 NA P{?lacW}eIF5BΔ2 NA P{PTT-GB}CB05358 NA P{SUPor-P}eIF5BKG09489 NA PBac{768.FSVS-0}eIF5BCPTI003501 NA PBac{PB}eIF5Bc02932 NA
Gene Ontology: Function, Process & Cellular Component ( 7 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 7 terms )
Molecular Function
CV term Evidence References
DEAD/H-box RNA helicase binding traceable author statement (Johnstone and Lasko, 2001) GTPase activity inferred from electronic annotation with InterPro:IPR000795 (FlyBase Curators et al., 2004-) GTP binding inferred from electronic annotation with InterPro:IPR000795, InterPro:IPR004161, InterPro:IPR005225 (FlyBase Curators et al., 2004-) translation initiation factor activity inferred from sequence or structural similarity (Lasko, 2000) inferred from sequence or structural similarity with Saccharomyces FUN12 (FlyBase, 1992-)
Biological Process
CV term Evidence References
translational initiation inferred from sequence or structural similarity (Lasko, 2000) inferred from sequence or structural similarity with Saccharomyces FUN12 (FlyBase, 1992-)
Cellular Component
CV term Evidence References
cytoplasm inferred from sequence or structural similarity (Lasko, 2000) cytosol inferred from sequence or structural similarity with Saccharomyces FUN12 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions eIF5B allele Gene References eIF5BΔ1 vas (Carrera et al., 2000)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 68928 DroID - A comprehensive database of gene and protein interactions. • FBgn0026259 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 44261
Orthologs
Genome-wide drosophilid orthologs	Dana\GF10267 Dere\GG14257 Dgri\GH15356 Dmoj\GI12960 Dper\GL13259 Dpse\GA10589 Dsec\GM14051 Dsim\GD13328 Dvir\GJ13104 Dwil\GK20376 Dyak\GE20685
Curated drosophilid orthologs	Dpse\GA10589
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL009241-PA Aedes aegypti (mosquito) AGAP004824-PA Anopheles gambiae (mosquito) XP_392101.3 Apis mellifera (honey bee) XP_001949877.1 Acyrthosiphon pisum (pea aphid) At1g76810.1 Arabidopsis thaliana (wall cress) 131372 Branchiostoma floridae (lancelet) BGIBMGA001265-PA Bombyx mori (silk worm) ENSBTAP00000034522 Bos taurus (bovine) CAL0001783 Candida albicans (a form of yeast) CBP10075 Caenorhabditis briggsae (nematode) CE42600 Caenorhabditis elegans (worm) ENSCAFP00000003313 Canis familiaris (dog) CAGL0M12144g Candida glabrata (haploid yeast) Chro.60256 Cryptosporidium hominis (obligate parasite) CML150C Cyanidioschyzon merolae (red alga) cn02466 Cryptococcus neoformans (yeast-like fungus) cgd6_2180 Cryptosporidium parvum (protozoan parasite) CPIJ015682 Culex pipens (mosquito) ENSCPOP00000010766 Cavia porcellus (guinea pig) 126465 Chlamidomonas reinhardtii (green alga) RP39369 Caenorhabditis remanei (nematode) ENSCSAVP00000015027 Ciona savignyi (sedentary tunicate) 154149 Capitella spl (polychaete worm) DDB0234259 Dictyostelium discoideum (amoeba) DEHA2C10956g Debaryomyces Hansenii (yeast) 205517 Daphnia pulex (daphnia) ENSDARP00000069175 Danio rerio (zebra fish) ENSECAP00000000080 Equus caballus (horse) XP_652306 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000013948 Gymnopilus aculeatus (mushroom) ENSGALP00000027015 Gallus gallus (chicken) GL50803_115239 Giardia lamblia (flagellated protozoan) 103835 Hypsipyla robusta (cedar shoot borer) ENSP00000289371 Homo sapiens (human) ISCW009538-PA Ixodes scapularis (deer tick) KLLA0F23265g Kluyveromyces lactis (yeast) 197410 Lottia gigantea (owl limpet) LmjF33.2740 Leishmania major (virus) 31545 Monocosta brevicollis (choanoflagellate) ENSMODP00000001676 Monodelphis domestica (gray opossum) ENSMMUP00000024930 Macaca mulatta (rhesus monkey) ENSMUSP00000027252 Mus musculus (house mouse) ENSOANP00000007325 Ornithorynchus anatinus (platypus) ENSORLP00000001890 Oryzias latipes (japanese killifish) LOC_Os05g51500.1 Oryza sativa (asian rice) 16311 Ostreococcus tauri (green alga) PFF0345w Plasmodium falciparum (protozoal parasite) PHUM003273-PA Pediculus humanus (human body louse) PP18408 Pristionchus pacificus (nematode) 146718 Physcomitrella patens (moss) ENSPPYP00000013483 Pongo pygmaeus (orangutan) 47235 Phytophthora ramorum (sudden oak death pathogen) 119003 Phytophthora sojae (root rot pathogen) 823158 Populus trichocarpa (black cottonwood) ENSPTRP00000051806 Pan troglodytes (chimpanzee) PVX_113515 Plasmodium vivax (protozoal parasite) ENSRNOP00000056379 Rattus norvegicus (norway rat) 5061080 Sorghum bicolor (sorghum) YAL035W Saccharomyces cerevisiae (budding yeast) Smp_006990 Schistosoma mansoni (trematode parasite) SPAC56F8.03 Schizosaccharomyces pombe (fission yeast) XP_001187110.1 Strongylocentrotus purpuratus (purple sea urchin) XP_001199006.1 Strongylocentrotus purpuratus (purple sea urchin) TA11735 Theileria annulata (apicomplexan parasite) XP_973325.1 Tribolium castaneum (red flour beetle) Tc00.1047053506235.10 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053511111.10 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000009354 Tetraodon nigroviridis (green spotted pufferfish) TP02_0181 Theileria parva (parasitic protozoan) 273 Thalassiosira pseudonana (marine diatom) ENSTRUP00000019316 Takifugu rubripes (pufferfish Takifugu) 127.m00107 Tetrahymena thermophila (ciliate protozoa) 88273.m00391 Trichomonas vaginalis (parasitic flagellated protozoan) YALI0A00803g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • LH14934 LH14930 ISCW009538 FBgn0237990 FBgn0222373 FBgn0200331 FBgn0185046 FBgn0168980 JGI_V11_205517 FBgn0070646 FBgn0150865 FBgn0135717 FBgn0122828 FBgn0106518 FBgn0087308 CPIJ015682 CPIJ008537 BGIBMGA001265 ACYPI007156 GB14171 AGAP004824 AAEL009241 PB24518 PHUM506500 GLEAN_07444
Stocks & Reagents
Stocks Listed in FlyBase ( 7 )
Bloomington	30626 y1 w*; Mi{MIC}eIF5BMI00125 19641 y1 w67c23; P{EPgy2}eIF5BEY01401 11735 P{PZ}eIF5B09143, l(3)0914309143 ry506/TM3, ryRK Sb1 Ser1
Harvard	- PBac{PB}eIF5Bc02932
Kyoto	111660 yd2 w1118 P{ey-FLP.N}2 P{GMR-lacZ.C(38.1)}TPN1; P{SUPor-P}eIF5BKG09489 P{neoFRT}80B/TM6B, P{Car20y}TPN1, Tb1
VDRC	v31365 w1118; P{GD7105}v31365 v31366 w1118; P{GD7105}v31366/CyO
Genomic Clones ( 3 )
	BACR09B04 BACR17M19 BACR22N09 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 83 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE11051
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT01593 AT02050 AT02786 AT02893 AT03223 AT05326 AT05426 AT08351 AT08461 AT11260 AT12157 AT18868 AT24749 AT26808 AT27221 AT30361 AT31237 GM10390 GM16290 GM20554 GM21079 GM29011 GM31807 LD42524 LP03795 LP06476 RE05316 RE11669 SD02425 SD08520 SD11813 SD14344 SD26136 SD26525
Other clones	102692 108786 522269 522954 523180 524429 571413 576521 bs46d04 bs46e09 bs61c09 CK01.17B.D2 CK01.20D.C6 CK01.23B.F3 CK01.78C.F2 CK01.87B.B2 Dmel_neb_016085_0564_2082 EK061153 EK069037 EK174146 EK235233 EN01714 EN03122 EN03551 EN05359 EN16824 EN16902 EN17839 EP17319 EP21428 FGC003F09 FGC024H08 FGM103A09 FGM209A06 RE01129 RM07484 RM07684 RM07884 RM07984 RM08184 RP001004437 RP001008497 RP001036156 RP001041369 RP001043903 RP001054516 RP001054600 UT01958
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0026259 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 44261
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: cIF2 CG10840 (Bayraktaroglu, 2000.8.7) Source for merge of: cIF2 CG14970 (FlyBase Genome Annotators, 2002-2003) Source for merge of: eIF5B anon-WO0118547.362 (FlyBase, 1996-)
Additional comments	Annotations CG10840 and CG14970 merged as CG10840 in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003) Source for merge of eIF5B anon-WO0118547.362 was sequence comparison (date:051113). (FlyBase, 1996-)
Other Comments
	Area matching Drosophila EST AA803203. Probable intron in gene represented by EST AA803203. (Davies, 2001.3.15) Identification: Protein that interacts with vas protein in a yeast two-hybrid assay. (Johnstone et al., 1999) Mutations in eIF5B are recessive lethal. Ovaries derived from homozygous germ line clones contain fewer egg chambers than normal, and those egg chambers that do form often have too many nurse cells and two oocytes. (Johnstone et al., 1999)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_143717 RefSeq (Proteins) • NP_651974 DDBJ / EMBL / GenBank • AA803203 AAF36532 AAF47774 AC004356 AF143207 AX094238 BG634223 BZ286337 CL610102 G00521 Entrez Gene - A searchable database of RefSeq genes. • 44261 UniProtKB/TrEMBL • Q9NJH7 Q9VZP5
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Protein synthesis factor, GTP-binding (IPR000795) Translation elongation factor EFTu/EF1A, domain 2 (IPR004161) Small GTP-binding protein domain (IPR005225) Translation elongation/initiation factor/Ribosomal, beta-barrel (IPR009000) Translation initiation factor IF- 2 (IPR015760) Translation initiation factor IF- 2, domain 3 (IPR023115)
Linkouts
	BioGRID - A database of protein and genetic interactions • 68928 DroID - A comprehensive database of gene and protein interactions. • FBgn0026259 DRSC - Results from RNAi screens. • FBgn0026259 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0026259 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10840-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0026259 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 44261 InParanoid A subset of ortholog calls from InParanoid. • AAEL009241-PA Aedes aegypti (mosquito) AGAP004824-PA Anopheles gambiae (mosquito) XP_392101.3 Apis mellifera (honey bee) XP_001949877.1 Acyrthosiphon pisum (pea aphid) At1g76810.1 Arabidopsis thaliana (wall cress) 131372 Branchiostoma floridae (lancelet) BGIBMGA001265-PA Bombyx mori (silk worm) ENSBTAP00000034522 Bos taurus (bovine) CAL0001783 Candida albicans (a form of yeast) CBP10075 Caenorhabditis briggsae (nematode) CE42600 Caenorhabditis elegans (worm) ENSCAFP00000003313 Canis familiaris (dog) CAGL0M12144g Candida glabrata (haploid yeast) Chro.60256 Cryptosporidium hominis (obligate parasite) CML150C Cyanidioschyzon merolae (red alga) cn02466 Cryptococcus neoformans (yeast-like fungus) cgd6_2180 Cryptosporidium parvum (protozoan parasite) CPIJ015682 Culex pipens (mosquito) ENSCPOP00000010766 Cavia porcellus (guinea pig) 126465 Chlamidomonas reinhardtii (green alga) RP39369 Caenorhabditis remanei (nematode) ENSCSAVP00000015027 Ciona savignyi (sedentary tunicate) 154149 Capitella spl (polychaete worm) DDB0234259 Dictyostelium discoideum (amoeba) DEHA2C10956g Debaryomyces Hansenii (yeast) 205517 Daphnia pulex (daphnia) ENSDARP00000069175 Danio rerio (zebra fish) ENSECAP00000000080 Equus caballus (horse) XP_652306 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000013948 Gymnopilus aculeatus (mushroom) ENSGALP00000027015 Gallus gallus (chicken) GL50803_115239 Giardia lamblia (flagellated protozoan) 103835 Hypsipyla robusta (cedar shoot borer) ENSP00000289371 Homo sapiens (human) ISCW009538-PA Ixodes scapularis (deer tick) KLLA0F23265g Kluyveromyces lactis (yeast) 197410 Lottia gigantea (owl limpet) LmjF33.2740 Leishmania major (virus) 31545 Monocosta brevicollis (choanoflagellate) ENSMODP00000001676 Monodelphis domestica (gray opossum) ENSMMUP00000024930 Macaca mulatta (rhesus monkey) ENSMUSP00000027252 Mus musculus (house mouse) ENSOANP00000007325 Ornithorynchus anatinus (platypus) ENSORLP00000001890 Oryzias latipes (japanese killifish) LOC_Os05g51500.1 Oryza sativa (asian rice) 16311 Ostreococcus tauri (green alga) PFF0345w Plasmodium falciparum (protozoal parasite) PHUM003273-PA Pediculus humanus (human body louse) PP18408 Pristionchus pacificus (nematode) 146718 Physcomitrella patens (moss) ENSPPYP00000013483 Pongo pygmaeus (orangutan) 47235 Phytophthora ramorum (sudden oak death pathogen) 119003 Phytophthora sojae (root rot pathogen) 823158 Populus trichocarpa (black cottonwood) ENSPTRP00000051806 Pan troglodytes (chimpanzee) PVX_113515 Plasmodium vivax (protozoal parasite) ENSRNOP00000056379 Rattus norvegicus (norway rat) 5061080 Sorghum bicolor (sorghum) YAL035W Saccharomyces cerevisiae (budding yeast) Smp_006990 Schistosoma mansoni (trematode parasite) SPAC56F8.03 Schizosaccharomyces pombe (fission yeast) XP_001187110.1 Strongylocentrotus purpuratus (purple sea urchin) XP_001199006.1 Strongylocentrotus purpuratus (purple sea urchin) TA11735 Theileria annulata (apicomplexan parasite) XP_973325.1 Tribolium castaneum (red flour beetle) Tc00.1047053506235.10 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053511111.10 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000009354 Tetraodon nigroviridis (green spotted pufferfish) TP02_0181 Theileria parva (parasitic protozoan) 273 Thalassiosira pseudonana (marine diatom) ENSTRUP00000019316 Takifugu rubripes (pufferfish Takifugu) 127.m00107 Tetrahymena thermophila (ciliate protozoa) 88273.m00391 Trichomonas vaginalis (parasitic flagellated protozoan) YALI0A00803g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 44261 modMine - Data generated by the modENCODE project. • FBgn0026259 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • LH14934 LH14930 ISCW009538 FBgn0237990 FBgn0222373 FBgn0200331 FBgn0185046 FBgn0168980 JGI_V11_205517 FBgn0070646 FBgn0150865 FBgn0135717 FBgn0122828 FBgn0106518 FBgn0087308 CPIJ015682 CPIJ008537 BGIBMGA001265 ACYPI007156 GB14171 AGAP004824 AAEL009241 PB24518 PHUM506500 GLEAN_07444
Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	A1 (Johnstone et al., 1999) anon-WO0118547.362   CG10840 (Lasko, 2000, Bayraktaroglu, 2000.8.7, Keleman et al., 2009.8.5) CG14970   cIF2 (Foley and O'Farrell, 2004, Bayraktaroglu, 2000.8.7, Lasko, 1999.3.3, Giot et al., 2003, ) dIF2 (Johnstone and Lasko, 2001, Lasko, 2000, Carrera et al., 2000) eIF5B (Linder and Lasko, 2006, Seydoux and Braun, 2006, Buszczak et al., 2007, Olivieri et al., 2010) IF2 (Brogna et al., 2002, Macdonald, 2001) yIF2 (Carrera, 1999.4.14)
Name Synonym	cytoplasmic Initiation Factor 2 (Lasko, 1999.3.3, ) eIF5B
Secondary FlyBase IDs
	FBgn0035446 FBgn0035447 FBgn0062068
References ( 35 )
Generate a list of	All references relating to this gene ( 35 )
List References by type	Research paper  ( 8 ) Supplementary material  ( 3 ) Review  ( 4 ) Personal communication to FlyBase  ( 8 ) Abstract  ( 2 ) FlyBase analysis  ( 4 ) DNA/RNA sequence record  ( 2 ) Patent  ( 1 ) Computer file  ( 2 ) Automatic genome annotation  ( 1 )
Recent research papers ( 1 )
	Olivieri et al., 2010, EMBO J. 29(19): 3301--3317 An in vivo RNAi assay identifies major genetic and cellular requirements for primary piRNA biogenesis in Drosophila. [FBrf0212004] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...