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General Information
Symbol
Dmel\Tsc1
Species
D. melanogaster
Name
Tsc1
Annotation Symbol
CG6147
Feature Type
FlyBase ID
FBgn0026317
Gene Model Status
Stock Availability
Gene Snapshot
Tsc1 (Tsc1) encodes a tumour suppressor protein that forms a complex with the product of gig. They control cellular growth via antagonizing insulin and TOR signalling pathways. [Date last reviewed: 2019-03-14]
Also Known As
dTsc1, TSC, rocky, tuberous sclerosis complex 1
Key Links
Genomic Location
Cytogenetic map
Sequence location
3R:24,130,307..24,134,654 [+]
Recombination map
3-83
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
Predictions / Assertions
-
Summaries
Pathway (FlyBase)
Negative Regulators of Insulin-like Receptor Signaling Pathway -
Negative regulators of the Insulin-like Receptor signaling pathway suppress Insulin-like receptor (InR) activation or the activity of intracellular effectors. (Adapted from FBrf0232297, FBrf0230017 and FBrf0229989).
Gene Group (FlyBase)
TSC1-TSC2 COMPLEX -
The Tsc1-Tsc2 complex is a heterodimeric GTPase Activating Protein (GAP) complex that negatively regulates mTOR (TORC1 complex) signaling. The Tsc1-Tsc2 complex stimulates the small GTPase, Rheb, to hydrolyze bound GTP to GDP. GTP-bound Rheb activates TORC1. (Adapted from FBrf0214848 and FBrf0136941).
Summary (Interactive Fly)
acts in conjunction with TSC2 to suppress cell growth by inhibiting Tor, a central controller of cell growth - TSC1/TSC2 has GAP activity toward the Rheb small GTPase which acts upstream of and stimulates TOR - TSC2 is the catalytic GAP subunit, while TSC1 enhances TSC2 function by stabilizing TSC2
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\Tsc1 or the JBrowse view of Dmel\Tsc1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.49
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0084546
3896
1100
Additional Transcript Data and Comments
Reported size (kB)
3.8 (longest cDNA)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0083931
124.8
1100
6.40
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Tsc1 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (35 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
inferred from physical interaction with FLYBASE:Tor; FB:FBgn0021796
inferred from physical interaction with FLYBASE:TBC1d7; FB:FBgn0039158
inferred from physical interaction with UniProtKB:Q9VS24
(assigned by UniProt )
inferred from physical interaction with UniProtKB:Q8T9I6
(assigned by UniProt )
Terms Based on Predictions or Assertions (0 terms)
Biological Process (30 terms)
Terms Based on Experimental Evidence (30 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:gig; FB:FBgn0005198
inferred from mutant phenotype
(assigned by UniProt )
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:gig; FB:FBgn0005198
inferred from genetic interaction with UniProtKB:Q8INB9
(assigned by UniProt )
inferred from mutant phenotype
(assigned by UniProt )
inferred from genetic interaction with FLYBASE:gig; FB:FBgn0005198
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:gig; FB:FBgn0005198
inferred from genetic interaction with UniProtKB:Q8T9I6
(assigned by UniProt )
inferred from genetic interaction with UniProtKB:Q9VW83
(assigned by UniProt )
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:gig; FB:FBgn0005198
inferred from genetic interaction with FLYBASE:Akt1; FB:FBgn0010379
inferred from high throughput mutant phenotype
inferred from genetic interaction with FLYBASE:gig; FB:FBgn0005198
inferred from mutant phenotype
inferred from mutant phenotype
inferred from genetic interaction with UniProtKB:Q9VW83
(assigned by UniProt )
inferred from mutant phenotype
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:Tor; FB:FBgn0021796
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000389117
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000389117
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000389117
(assigned by GO_Central )
Cellular Component (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
inferred from direct assay
(assigned by UniProt )
inferred from direct assay
inferred from physical interaction with FLYBASE:gig; FB:FBgn0005198
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000389117
(assigned by GO_Central )
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
inferred from direct assay
(assigned by UniProt )
inferred from direct assay
inferred from physical interaction with FLYBASE:gig; FB:FBgn0005198
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Tsc1 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 15 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 28 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Tsc1
Transgenic constructs containing regulatory region of Tsc1
Deletions and Duplications ( 3 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
eye disc & mitotic cell cycle | ectopic | somatic clone
eye disc & mitotic cell cycle | somatic clone
eye disc & S phase | ectopic | somatic clone
eye disc & S phase | somatic clone
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
12 of 15
Yes
Yes
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
10 of 15
Yes
Yes
Rattus norvegicus (Norway rat) (1)
11 of 13
Yes
Yes
Xenopus tropicalis (Western clawed frog) (1)
1 of 12
Yes
Yes
Danio rerio (Zebrafish) (2)
11 of 15
Yes
Yes
9 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (0)
No records found.
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (1)
2 of 12
Yes
Yes
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091901F2 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091502RL )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W04E8 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X04B0 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G01O5 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Ciona intestinalis
Vase tunicate
Gallus gallus
Domestic chicken
Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (0)
No records found.
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 3 )
Potential Models Based on Orthology ( 2 )
Human Ortholog
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 3 )
Comments on Models/Modifiers Based on Experimental Evidence ( 2 )
 
The amelioration of the phenotype in Npc1aKK101077 expressing flies is observed upon simultaneous co-expression of both Tsc1Scer\UAS.cTa and gigScer\UAS.cTa. sf161013
Co-expression (single expression of either construct untested) of Tsc1Scer\UAS.cGa and gigScer\UAS.cTa ameliorates neurodegenerative disease modeled by trpP365.
Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Interactions
Summary of Physical Interactions
esyN Network Diagram
Show neighbor-neighbor interactions:
Select Layout:
Legend:
Protein
RNA
Selected Interactor(s)
Interactions Browser

Please see the Physical Interaction reports below for full details
protein-protein
Physical Interaction
Assay
References
Summary of Genetic Interactions
esyN Network Diagram
esyN Network Key:
Suppression
Enhancement

Please look at the allele data for full details of the genetic interactions
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
External Data
Linkouts
BioGRID - A database of protein and genetic interactions.
DroID - A comprehensive database of gene and protein interactions.
InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
Pathways
Gene Group - Pathway Membership (FlyBase)
Negative Regulators of Insulin-like Receptor Signaling Pathway -
Negative regulators of the Insulin-like Receptor signaling pathway suppress Insulin-like receptor (InR) activation or the activity of intracellular effectors. (Adapted from FBrf0232297, FBrf0230017 and FBrf0229989).
External Data
Genomic Location and Detailed Mapping Data
Chromosome (arm)
3R
Recombination map
3-83
Cytogenetic map
Sequence location
3R:24,130,307..24,134,654 [+]
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
95E1-95E1
Limits computationally determined from genome sequence between P{PZ}Syx1A06737&P{PZ}Syx1A10660 and P{PZ}crb07207&P{PZ}BRWD305842
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
Location based on deficiency mapping with Df(3R)crb-F89-4 and Df(3R)3450.
95E4-95E5
95E4-95E5
(determined by in situ hybridisation)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Stocks and Reagents
Stocks (27)
Genomic Clones (14)
 

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (58)
 

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequences
BDGP DGC clones
Other clones
Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)
RNAi and Array Information
Linkouts
DRSC - Results frm RNAi screens
GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
Antibody Information
Laboratory Generated Antibodies
 
Commercially Available Antibodies
 
Other Information
Relationship to Other Genes
Source for database identify of
Source for identity of: Tsc1 CG6147
Source for database merge of
Source for merge of: Tsc1 rocky
Additional comments
Other Comments
Tsc1 negatively regulates bantam activity.
dsRNA made from templates generated with primers directed against this gene significantly increases the level of S6k phosphorylation and decreases the level of Akt1 phosphorylation, especially in response to insulin stimulation, in S2 cells.
Tsc1 controls the timing of differentiation in the developing eye.
Tsc1 acts as part of a complex with gig to antagonise Tor.
Loss of Tsc1 and gig results in a Tor-dependent increase in S6k activity. Tsc1 mutant cells fail to respond to amino acid starvation by decreasing S6k activity.
Evidence from dsRNAi in Drosophila cell culture suggests that Tsc1 and gig are necessary for wild-type levels of S6k and Akt1 activity.
Tsc1 is a negative regulator of insulin signalling.
Cells mutant for Tsc1 are dramatically increased in size yet differentiate normally.
Mutations in Tsc1 result in enhanced growth and cell size with no change in ploidy. Overall, mutant cells spend less time in G1.
Cells in mutant clones are significantly larger than their wild-type neighbours and contain larger nuclei.
Origin and Etymology
Discoverer
Etymology
Identification
External Crossreferences and Linkouts ( 51 )
Sequence Crossreferences
NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
Other crossreferences
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
InterPro - A database of protein families, domains and functional sites
KEGG Genes - Molecular building blocks of life in the genomic space.
KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
modMine - A data warehouse for the modENCODE project
Linkouts
BioGRID - A database of protein and genetic interactions.
DPiM - Drosophila Protein interaction map
DroID - A comprehensive database of gene and protein interactions.
DRSC - Results frm RNAi screens
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyMine - An integrated database for Drosophila genomics
Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
Synonyms and Secondary IDs (21)
Reported As
Symbol Synonym
TSC1
(Galenza and Foley, 2019, Inoue et al., 2018, Staats et al., 2018, Tang et al., 2018, Haller et al., 2017, Liu and Jin, 2017, Stefana et al., 2017, Sun et al., 2017, Wen et al., 2017, Agrawal et al., 2016, Danielsen et al., 2016, Koyama and Mirth, 2016, Aradhya et al., 2015, Burn et al., 2015, Fischer et al., 2015, Housden et al., 2015, Nässel et al., 2015, Sano et al., 2015, Zhang and Baehrecke, 2015, Zhang et al., 2015, Mulakkal et al., 2014, Varma et al., 2014, Koyama et al., 2013, Quan et al., 2013, Shim et al., 2013, Sim and Denlinger, 2013, Tang et al., 2013, Wong et al., 2013, Yamanaka et al., 2013, Denton et al., 2012, Kapuria et al., 2012, Lv et al., 2012, Mirth and Shingleton, 2012, Pallares-Cartes et al., 2012, Papatheodorou et al., 2012, Tokusumi et al., 2012, Wang et al., 2012, Zitserman et al., 2012, Ghabrial et al., 2011, Oldham, 2011, Serfontein et al., 2011, Storelli et al., 2011, Yang and Xu, 2011, Birse et al., 2010, Bland et al., 2010, Chang and Neufeld, 2010, Cully et al., 2010, Hsieh et al., 2010, Karbowniczek et al., 2010, Lam et al., 2010, Ribeiro and Dickson, 2010, Géminard et al., 2009, Read et al., 2009, Slaidina et al., 2009, Layalle et al., 2008, Teleman et al., 2008, Bourouis et al., 2007, Hietakangas and Cohen, 2007, Hoshizaki and Gibbs, 2007, Hsu and Choi, 2007, Knox et al., 2007, Lasko and Sonenberg, 2007, Martin et al., 2007, Tyler et al., 2007, Dorer et al., 2006, Edgar, 2006, Lee et al., 2006, Min et al., 2006, Nolo et al., 2006, Wu and Brown, 2006, Yang et al., 2006, Mikeladze-Dvali et al., 2005, Hay and Sonenberg, 2004, Colombani et al., 2003, Lee and Orr-Weaver, 2003, Neufeld, 2003, Nijhout, 2003, Stocker et al., 2003, Hengstschlaeger et al., 2001, Tapon and Hariharan, 2001, Ito, 1999.7.29)
Tsc1
(Sharma et al., 2019, Alfred and Vaccari, 2018, Calap-Quintana et al., 2018, Jia et al., 2018, Kang et al., 2018, Lehmann, 2018, Nowak et al., 2018, Mensah et al., 2017, Murillo-Maldonado and Riesgo-Escovar, 2017, Song et al., 2017, Transgenic RNAi Project members, 2017-, Allen et al., 2016, Cai et al., 2016, Dong et al., 2016, Kuleesha et al., 2016, Sarov et al., 2016, Vinayagam et al., 2016, Yadav et al., 2016, Androschuk et al., 2015, Calap-Quintana et al., 2015, Das and Dobens, 2015, Hatfield et al., 2015, Sopko et al., 2015, Wang et al., 2015, Avet-Rochex et al., 2014, Deivasigamani et al., 2014, Ghosh et al., 2014, Kim and Choe, 2014, Wei and Lilly, 2014, Wei et al., 2014, Natarajan et al., 2013, Nowak et al., 2013, Schertel et al., 2013, Sopko and Perrimon, 2013, Tran et al., 2013, Zirin et al., 2013, Alvarez-Ponce et al., 2012, Avet-Rochex et al., 2012, Hafezi et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Kapuria et al., 2012, Marinari et al., 2012, Papatheodorou et al., 2012, Yaniv et al., 2012, Glatter et al., 2011, Lindquist et al., 2011, Sousa-Nunes et al., 2011, Zhang et al., 2011, Kockel et al., 2010, LaFever et al., 2010, Lee et al., 2010, Montagne et al., 2010, Nisoli et al., 2010, Pospisilik et al., 2010, Potter et al., 2010, Potter et al., 2010, Potter et al., 2010, Sun et al., 2010, Zheng and Sehgal, 2010, Chang and Neufeld, 2009, Chang and Neufeld, 2009, Demontis and Perrimon, 2009, Nuzhdin et al., 2009, Patel et al., 2009, Ravi et al., 2009, Schleich and Teleman, 2009, Sims et al., 2009, Wang et al., 2009, Harvey et al., 2008, Hou et al., 2008, Juhász et al., 2008, Lee et al., 2008, Vereshchagina et al., 2008, Xu et al., 2008, Gutierrez et al., 2007, Hsu et al., 2007, Tseng et al., 2007, Hamaratoglu et al., 2006, Hennig et al., 2006, Igaki et al., 2006, Igaki et al., 2006, Patel and Tamanoi, 2006, Silva, 2006, Goberdhan et al., 2005, Jordan et al., 2005, Teleman et al., 2005, Terashima and Bownes, 2005, Aspuria and Tamanoi, 2004, Udan et al., 2003)
Name Synonyms
TTuberous Sclerosis Complex 1
Tuberous Sclerosis 1
Tuberous Sclerosis Complex 1
jolly green giant
tuberous sclerosis 1
tuberous sclerosis complex protein 1
Secondary FlyBase IDs
    Datasets (1)
    Study focus (1)
    Experimental Role
    Project
    Project Type
    Title
    • bait_protein
    Interaction map generated by purification of insulin pathway factors, with identification of copurifying proteins by mass spectrometry.
    References (312)