dTsc1, TSC, rocky, tuberous sclerosis complex 1
acts in conjunction with TSC2 to suppress cell growth by inhibiting Tor, a central controller of cell growth - TSC1/TSC2 has GAP activity toward the Rheb small GTPase which acts upstream of and stimulates TOR - TSC2 is the catalytic GAP subunit, while TSC1 enhances TSC2 function by stabilizing TSC2
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.49
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Tsc1 using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Tsc1 in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
dsRNA made from templates generated with primers directed against this gene significantly increases the level of S6k phosphorylation and decreases the level of Akt1 phosphorylation, especially in response to insulin stimulation, in S2 cells.
Cells mutant for Tsc1 are dramatically increased in size yet differentiate normally.
Mutations in Tsc1 result in enhanced growth and cell size with no change in ploidy. Overall, mutant cells spend less time in G1.
Cells in mutant clones are significantly larger than their wild-type neighbours and contain larger nuclei.