FB2020_02, released Apr 14, 2020

Gene: Dmel\Traf4

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General Information
Symbol
Dmel\Traf4
Species
D. melanogaster
Name
TNF-receptor-associated factor 4
Annotation Symbol
CG3048
Feature Type
protein_coding_gene
FlyBase ID
FBgn0026319
Gene Model Status
Current
Stock Availability
9 publicly available
Gene Snapshot
TNF-receptor-associated factor 4 (Traf4) encodes an adapter protein thought to bind the TNF receptor and activate downstream signaling. However, it also has TNF independent roles, especially with respect to morphogenesis. The product of Traf4 interacts with and localizes polarity and adherens junction proteins such as the products of baz and arm respectively. It is required for normal embryonic development, cell death, and cell growth. [Date last reviewed: 2019-03-14]
Other Summaries
Also Known As

Traf1, DTRAF1

Key Links
Genomic Location
Cytogenetic map
24E1-24E4
Sequence location
2L:4,361,925..4,380,716 [+]
Recombination map

2-12

RefSeq locus
NT_033779 REGION:4361925..4380716
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
protein binding
Predictions / Assertions
ubiquitin-protein transferase activity; zinc ion binding
Summaries
Gene Group (FlyBase)
TNF RECEPTOR ASSOCIATED FACTORS -
TNF receptor associated factors (TRAFs) were originally identified as intracellular signal transducers for members of the TNF receptor (TNFR) family in mammals. In Drosophila, TRAFs act downstream of Toll and other homologous receptors (a function shared with some mammalian TRAFs). TRAFs act as adaptor molecules, binding the cytoplasmic tail of activated receptors to recruit other signalling molecules or complexes. All TRAFs contain a C-terminal TRAF domain which interacts with the receptor. (Adapted from FBrf0135895).
Summary (Interactive Fly)

Traf domain protein - involved in signal transduction in the JNK and pathway - an adapter protein thought to bind the TNF receptor and activate downstream signaling - interacts with and localizes polarity and adherens junction proteins such as Bazooka and Armadillo respectively - required for normal embryonic development, cell death, and cell growth

Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
2

Please see the GBrowse view of Dmel\Traf4 or the JBrowse view of Dmel\Traf4 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.47

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Traf4-RA
FBtr0077429
NM_058068
2361
486
Traf4-RE
FBtr0334401
NM_001103610
2675
477
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Traf4-PA
FBpp0077119
53.7
486
8.74
NP_477416
AAF51024
Traf4-PE
FBpp0306504
52.9
477
8.63
NP_001097080
ABV53619
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)

486 (aa)

(Liu et al., 1999)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Traf4 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (20 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
protein binding
inferred from physical interaction with FLYBASE:baz; FB:FBgn0000163
(Wang et al., 2006)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
ubiquitin-protein transferase activity
inferred from biological aspect of ancestor with PANTHER:PTN000805648
(assigned by GO_Central )
(Gaudet et al., 2011)
zinc ion binding
inferred from electronic annotation with InterPro:IPR001293, InterPro:IPR012227, InterPro:IPR013323
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Biological Process (14 terms)
Terms Based on Experimental Evidence (9 terms)
CV Term
Evidence
References
adherens junction organization
inferred from mutant phenotype
(Mathew et al., 2011)
apical constriction involved in gastrulation
inferred from mutant phenotype
(Mathew et al., 2011)
asymmetric protein localization involved in cell fate determination
inferred from mutant phenotype
(Wang et al., 2006)
defense response to Gram-negative bacterium
inferred from mutant phenotype
(Berkey et al., 2009)
eye development
inferred from mutant phenotype
(Cha et al., 2003)
imaginal disc fusion, thorax closure
inferred from genetic interaction with FLYBASE:bsk; FB:FBgn0000229
(Cha et al., 2003)
positive regulation of apoptotic process
inferred from mutant phenotype
(Cha et al., 2003)
positive regulation of JNK cascade
inferred from genetic interaction with FLYBASE:bsk; FB:FBgn0000229
(Cha et al., 2003)
inferred from genetic interaction with FLYBASE:hep; FB:FBgn0010303
(Cha et al., 2003)
inferred from genetic interaction with FLYBASE:Tak1; FB:FBgn0026323
(Cha et al., 2003)
ventral furrow formation
inferred from mutant phenotype
(Mathew et al., 2009)
Terms Based on Predictions or Assertions (6 terms)
CV Term
Evidence
References
activation of NF-kappaB-inducing kinase activity
inferred from electronic annotation with InterPro:IPR027138
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
dorsal closure
traceable author statement
(Noselli and Agnes, 1999)
positive regulation of JNK cascade
inferred from biological aspect of ancestor with PANTHER:PTN000805648
(assigned by GO_Central )
(Gaudet et al., 2011)
protein K63-linked ubiquitination
inferred from biological aspect of ancestor with PANTHER:PTN000805648
(assigned by GO_Central )
(Gaudet et al., 2011)
regulation of I-kappaB kinase/NF-kappaB signaling
inferred from biological aspect of ancestor with PANTHER:PTN000805648
(assigned by GO_Central )
(Gaudet et al., 2011)
tumor necrosis factor-mediated signaling pathway
inferred from biological aspect of ancestor with PANTHER:PTN000805648
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
apical cortex
inferred from direct assay
(Wang et al., 2006)
apical part of cell
inferred from direct assay
(Mathew et al., 2011)
cytoplasm
inferred from direct assay
(Wang et al., 2006)
Terms Based on Predictions or Assertions (0 terms)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 4 -- 6
anlage in statu nascendi
(Fisher et al., 2012)
hindgut anlage in statu nascendi
(Fisher et al., 2012)
mesoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
trunk mesoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
ventral ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
yolk
(Fisher et al., 2012)
yolk nucleus
(Fisher et al., 2012)
embryonic stage 7 -- 8
dorsal ectoderm
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
yolk nucleus
(Fisher et al., 2012)
embryonic stage 9 -- 10
antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal ectoderm
(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 11 -- 12
central brain primordium
(Fisher et al., 2012)
embryonic central brain glial cell
(Fisher et al., 2012)
embryonic central brain neuron
(Fisher et al., 2012)
embryonic ganglion mother cell
(Fisher et al., 2012)
embryonic neuroblast of ventral nerve cord primordium
(Fisher et al., 2012)
lateral cord glial cell
(Fisher et al., 2012)
lateral cord neuron
(Fisher et al., 2012)
procephalic neuroblast
(Fisher et al., 2012)
stomatogastric nervous system primordium
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
embryonic central brain neuron
(Fisher et al., 2012)
embryonic head sensory system
(Fisher et al., 2012)
embryonic stomatogastric nervous system
(Fisher et al., 2012)
embryonic/larval nervous system
(Fisher et al., 2012)
lateral cord neuron
(Fisher et al., 2012)
sensory nervous system primordium
(Fisher et al., 2012)
ventral nerve cord
(Fisher et al., 2012)
median neuroblast MNB interneuron
(Kearney et al., 2004)
MP1 neuron
(Kearney et al., 2004)
embryonic stage 5 -- 6
mesoderm anlage
(Mathew et al., 2011)
hindgut anlage
(Mathew et al., 2011)
mesectoderm | subset
(Kearney et al., 2004)
embryonic stage 9 -- 12
midline primordium | subset
(Kearney et al., 2004)
embryonic stage 11 -- 13
cardiogenic mesoderm
(Ahmad et al., 2012)
embryonic stage 16 -- 17
embryonic/larval heart
(Ahmad et al., 2012)
embryonic/larval cardial cell
(Ahmad et al., 2012)
embryonic/larval pericardial cell
(Ahmad et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 5
cell | apical
(Mathew et al., 2011)
embryonic stage 6 -- 8
cell | apical of mesoderm
(Mathew et al., 2011)
Additional Descriptive Data

Traf4 protein is apically distributed in cellular blastoderms through ventral furrow formation. Traf4 protein localization remains tightly apical in mesodermal cells during ventral furrow formation, while weaker staining can be observed to extend basally during gastrulation.

(Mathew et al., 2011)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
apical cortex
inferred from direct assay
(Wang et al., 2006)
apical part of cell
inferred from direct assay
(Mathew et al., 2011)
cytoplasm
inferred from direct assay
(Wang et al., 2006)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Traf4 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 11 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Traf4
Transgenic constructs containing regulatory region of Traf4
Deletions and Duplications ( 11 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal (with Traf43)
lethal (with Traf4L2)
lethal - all die before end of larval stage
lethal - all die before end of pupal stage
partially lethal, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
immune response defective
increased cell death, with Scer\GAL4Act5C.PHb
increased cell death, with Scer\GAL4GMR.PF
size defective | larval stage
some die during larval stage
some die during pupal stage
some die during pupal stage, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
visible, with Scer\GAL4ey.PH
visible, with Scer\GAL4GMR.PF
Phenotype manifest in
Allele
embryonic/first instar larval cuticle | rescuable maternal effect
embryonic/larval salivary gland, with Scer\GAL4fkh.PH
eye, with Scer\GAL4ey.PH
eye, with Scer\GAL4GMR.PF
eye disc
eye disc, with Scer\GAL4GMR.PF
eye photoreceptor cell, with Scer\GAL4GMR.PF
eye photoreceptor cell & axon
imaginal disc
ommatidium, with Scer\GAL4GMR.PF
ventral furrow
ventral furrow, with Scer\GAL4twi.PG
ventral furrow (with Df(2L)ed-dp)
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (12)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\TRAF4
14 of 15
Yes
Yes
Hsap\TRAF1
3 of 15
No
Yes
Hsap\TRAF2
3 of 15
No
Yes
Hsap\TRAF3
3 of 15
No
Yes
Hsap\RNF41
2 of 15
No
No
Hsap\RNF151
2 of 15
No
No
Hsap\TRAF5
2 of 15
No
Yes
Hsap\TRAF6
2 of 15
No
No
Hsap\LNX1
1 of 15
No
No
 
Hsap\PDZRN3
1 of 15
No
No
Hsap\PDZRN4
1 of 15
No
No
Hsap\TRAF7
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (12)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Traf4
14 of 15
Yes
Yes
Mmus\Traf1
3 of 15
No
Yes
Mmus\Traf2
3 of 15
No
Yes
Mmus\Traf3
3 of 15
No
Yes
Mmus\Rnf41
2 of 15
No
No
Mmus\Rnf151
2 of 15
No
No
Mmus\Traf6
2 of 15
No
No
Mmus\Lnx1
1 of 15
No
No
Mmus\Pdzrn3
1 of 15
No
No
Mmus\Pdzrn4
1 of 15
No
No
Mmus\Traf5
1 of 15
No
No
Mmus\Traf7
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (10)
Rnor\Traf4
12 of 13
Yes
Yes
Rnor\Rnf41
2 of 13
No
No
Rnor\Rnf151
2 of 13
No
No
Rnor\Traf1
2 of 13
No
Yes
Rnor\Traf2
2 of 13
No
No
Rnor\Traf3
2 of 13
No
Yes
Rnor\Traf6
2 of 13
No
No
Rnor\Lnx1
1 of 13
No
No
Rnor\Traf5
1 of 13
No
Yes
Rnor\Traf7
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (11)
Xtro\traf4
9 of 12
Yes
Yes
Xtro\traf3
3 of 12
No
Yes
Xtro\rnf41
2 of 12
No
No
Xtro\traf2
2 of 12
No
Yes
Xtro\traf5
2 of 12
No
Yes
Xtro\traf6
2 of 12
No
No
Xtro\lnx1
1 of 12
No
No
Xtro\pdzrn3
1 of 12
No
No
Xtro\rnf151
1 of 12
No
No
Xtro\traf1
1 of 12
No
Yes
Xtro\traf7
1 of 12
No
Yes
Danio rerio (Zebrafish) (16)
Drer\traf4a
14 of 15
Yes
Yes
Drer\traf4b
13 of 15
No
Yes
Drer\traf1
3 of 15
No
Yes
Drer\traf2a
3 of 15
No
Yes
Drer\LOC100005446
2 of 15
No
No
Drer\rnf41
2 of 15
No
No
Drer\rnf41l
2 of 15
No
No
Drer\rnf151
2 of 15
No
No
Drer\traf2b
2 of 15
No
No
Drer\traf3
2 of 15
No
Yes
Drer\traf5
2 of 15
No
Yes
Drer\traf6
2 of 15
No
No
Drer\lnx2b
1 of 15
No
No
Drer\pdzrn3a
1 of 15
No
No
Drer\pdzrn3b
1 of 15
No
No
Drer\traf7
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (2)
Cele\trf-1
8 of 15
Yes
Yes
Cele\trf-2
5 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (5)
Atha\ARI10
1 of 9
Yes
No
Atha\AT3G11950
1 of 9
Yes
Yes
Atha\AT3G58400
1 of 9
Yes
Yes
Atha\AT5G37900
1 of 9
Yes
Yes
Atha\AT5G37910
1 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG0919075G )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00000702
Drosophila simulans
Dsim\GD23279
Drosophila sechellia
Dsec\GM18466
Drosophila erecta
Dere\GG24996
Drosophila yakuba
Dyak\Traf1
Drosophila ananassae
Dana\GF21137
Drosophila pseudoobscura pseudoobscura
Dpse\GA25491
Drosophila persimilis
Dper\GL15107
Drosophila willistoni
Dwil\GK24337
Drosophila virilis
Dvir\GJ16121
Drosophila mojavensis
Dmoj\GI22040
Drosophila grimshawi
Dgri\GH13208
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091504JH )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17006096
Musca domestica
House fly
Mdoa\17008010
Musca domestica
House fly
Mdoa\17006111
Glossina morsitans
Tsetse fly
Gmor\GMOY006356
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_14324
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL006649
Anopheles darlingi
American malaria mosquito
Adar\ADAC001482
Anopheles gambiae
Malaria mosquito
Agam\AGAP010017
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ005312
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W065B )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Danaus plexippus
Monarch butterfly
Dple\DPOGS209601-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL007248
Apis florea
Little honeybee
Aflo\2620475028
Apis mellifera
Western honey bee
Amel\GB46952
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP13883
Bombus terrestris
Buff-tailed bumblebee
Bter\15215313
Linepithema humile
Argentine ant
Lhum\LH10823
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001b6c
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG012701
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_11258
Tribolium castaneum
Red flour beetle
Tcas\TC034344
Pediculus humanus
Human body louse
Phum\PHUM275010
Rhodnius prolixus
Kissing bug
Rpro\RPRC006577
Cimex lectularius
Bed bug
Clec\CLEC003864
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI000855
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_17913
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X060W )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR001282
Strigamia maritima
European centipede
Smar\SMAR007785
Ixodes scapularis
Black-legged tick
Isca\ISCW005120
Ixodes scapularis
Black-legged tick
Isca\ISCW000732
Ixodes scapularis
Black-legged tick
Isca\ISCW015053
Ixodes scapularis
Black-legged tick
Isca\ISCW002862
Stegodyphus mimosarum
African social velvet spider
Smim\KFM57595.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM57516.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM57596.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur28g01060
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_51929
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0GHD )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-traf1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-traf3
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-traf4
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-traf6
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-traf3_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-traf1_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-traf
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-trafA
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-trafB
Ciona intestinalis
Vase tunicate
Cint\LOC100179623
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000004316
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000020502
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000001576
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000021357
Ciona intestinalis
Vase tunicate
Cint\zf(traf/ring)-1
Ciona intestinalis
Vase tunicate
Cint\LOC100178481
Gallus gallus
Domestic chicken
Ggal\TRAF1
Gallus gallus
Domestic chicken
Ggal\TRAF6
Gallus gallus
Domestic chicken
Ggal\TRAF2
Gallus gallus
Domestic chicken
Ggal\TRAF3
Gallus gallus
Domestic chicken
Ggal\TRAF-5
Gallus gallus
Domestic chicken
Ggal\TRAF4
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (4)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Traf6
4 of 10
CG9014
2 of 10
elgi
2 of 10
Traf-like
2 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Interaction
    References
    Traf4ex1
    ameliorates  retinitis pigmentosa
    modeled by ninaEP37H, ninaE17
    (Griciuc et al., 2014)
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    TRAF4; TNF receptor associated factor 4
    14 of 15
    602464
        TRAF1; TNF receptor associated factor 1
        3 of 15
        601711
            TRAF2; TNF receptor associated factor 2
            3 of 15
            601895
                TRAF3; TNF receptor associated factor 3
                3 of 15
                601896
                  Functional Complementation Data
                  Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                  Interactions
                  Summary of Physical Interactions
                  Summary of Genetic Interactions
                  esyN Network Diagram
                  esyN Network Key:
                  Suppression
                  Enhancement
                  View in Interactions Browser
                  Please look at the allele data for full details of the genetic interactions
                  Starting gene(s)
                  Interaction type
                  Interacting gene(s)
                  Reference
                  Traf4
                  enhanceable
                  arm
                  (Mathew et al., 2011)
                  Traf4
                  enhanceable
                  bsk
                  (Cha et al., 2003)
                  Traf4
                  suppressible
                  CycE
                  (Tseng and Hariharan, 2002)
                  Traf4
                  suppressible
                  Diap1
                  (Kuranaga et al., 2002)
                  Traf4
                  suppressible
                  hep
                  (Cha et al., 2003, Kuranaga et al., 2002)
                  Traf4
                  suppressible
                  park
                  (Cha et al., 2005)
                  Traf4
                  suppressible
                  Tak1
                  (Cha et al., 2003)
                  Traf4
                  enhanceable
                  Tak1
                  (Cha et al., 2003)
                  Starting gene(s)
                  Interaction type
                  Interacting gene(s)
                  Reference
                  arm
                  enhanceable
                  Traf4
                  (Mathew et al., 2011)
                  bsk
                  enhanceable
                  Traf4
                  (Cha et al., 2003)
                  mbl
                  suppressible
                  Traf4
                  (Vicente-Crespo et al., 2008)
                  mbl
                  enhanceable
                  Traf4
                  (Vicente-Crespo et al., 2008)
                  ninaE
                  suppressible
                  Traf4
                  (Griciuc et al., 2014)
                  park
                  suppressible
                  Traf4
                  (Cha et al., 2005)
                  Rab11
                  enhanceable
                  Traf4
                  (Tiwari and Roy, 2009)
                  Rala
                  enhanceable
                  Traf4
                  (Balakireva et al., 2006)
                  Ras85D
                  suppressible
                  Traf4
                  (Wu et al., 2009)
                  shg
                  suppressible
                  Traf4
                  (Mathew et al., 2011)
                  External Data
                  Linkouts
                  BioGRID - A database of protein and genetic interactions.
                  DroID - A comprehensive database of gene and protein interactions.
                  InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                  MIST (genetic) - An integrated Molecular Interaction Database
                  MIST (protein-protein) - An integrated Molecular Interaction Database
                  Pathways
                  Signaling Pathways (FlyBase)
                  Metabolic Pathways
                  External Data
                  Linkouts
                  KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
                  Genomic Location and Detailed Mapping Data
                  Chromosome (arm)
                  2L
                  Recombination map

                  2-12

                  Cytogenetic map
                  24E1-24E4
                  Sequence location
                  2L:4,361,925..4,380,716 [+]
                  FlyBase Computed Cytological Location
                  Cytogenetic map
                  Evidence for location
                  24E1-24E4
                  Limits computationally determined from genome sequence between P{EP}Traf1EP578 and P{lacW}Tps1k08903&P{EP}morgueEP1184
                  Experimentally Determined Cytological Location
                  Cytogenetic map
                  Notes
                  References
                  Experimentally Determined Recombination Data
                  Location

                  2-12

                  (FlyBase, 2016)

                  2-13.1

                  (Comeron et al., 2012)
                  Left of (cM)
                  Right of (cM)
                  Notes
                  Stocks and Reagents
                  Stocks (9)
                  Genomic Clones (24)
                  cDNA Clones (31)
                   

                  Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                  cDNA clones, fully sequences
                  BDGP DGC clones
                  Other clones
                  Drosophila Genomics Resource Center cDNA clones

                  For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                  cDNA Clones, End Sequenced (ESTs)
                  BDGP DGC clones
                  Other clones
                  RNAi and Array Information
                  Linkouts
                  DRSC - Results frm RNAi screens
                  GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                  Antibody Information
                  Laboratory Generated Antibodies
                   

                  polyclonal

                  (Mathew et al., 2011)
                  Commercially Available Antibodies
                   
                  Other Information
                  Relationship to Other Genes
                  Source for database identify of

                  Source for identity of: Traf4 Traf1

                  (Leptin et al., 2008.2.11)
                  Source for database merge of
                  Additional comments
                  Other Comments

                  Gene expression is increased in response to the presence of two copies of Scer\GAL4hs.PB.

                  (Liu and Lehmann, 2008)

                  S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.

                  (Stroschein-Stevenson et al., 2006)

                  Identification: Identified as a protein that interacts with msn in a yeast two-hybrid screen.

                  (Liu et al., 1999)
                  Origin and Etymology
                  Discoverer
                  Etymology
                  Identification
                  External Crossreferences and Linkouts ( 56 )
                  Sequence Crossreferences
                  NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                  GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                  GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                  RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                  UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                  Other crossreferences
                  BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                  Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                  Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                  Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                  Flygut - An atlas of the Drosophila adult midgut
                  GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                  iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                  InterPro - A database of protein families, domains and functional sites
                  KEGG Genes - Molecular building blocks of life in the genomic space.
                  modMine - A data warehouse for the modENCODE project
                  SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                  Linkouts
                  BioGRID - A database of protein and genetic interactions.
                  DPiM - Drosophila Protein interaction map
                  DroID - A comprehensive database of gene and protein interactions.
                  DRSC - Results frm RNAi screens
                  FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                  FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                  FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                  FlyMine - An integrated database for Drosophila genomics
                  Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                  InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                  KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
                  MIST (genetic) - An integrated Molecular Interaction Database
                  MIST (protein-protein) - An integrated Molecular Interaction Database
                  Synonyms and Secondary IDs (23)
                  Reported As
                  Symbol Synonym
                  CG3048
                  (Hosono et al., 2015, Ahmad et al., 2012, Aerts et al., 2010, Ni et al., 2010.12.1, Seinen et al., 2010, Keleman et al., 2009.8.5, Carrera et al., 2008, Brandt, 2006, Cha et al., 2003)
                  DTRAF
                  (Xia and Karin, 2004)
                  DTRAF1
                  (Griciuc et al., 2014, Mallik and Lakhotia, 2009, Tiwari and Roy, 2009, Wu et al., 2009, Kuranaga and Miura, 2007, Igaki et al., 2006, Wang et al., 2006, Varfolomeev and Ashkenazi, 2004, Cha et al., 2003, Kuranaga et al., 2003, Kuranaga et al., 2002, Zapata et al., 2000, Liu et al., 1999, Noselli and Agnes, 1999)
                  TRAF
                  (Kyriakis, 1999)
                  TRAF1
                  (Lee et al., 2018, Mathew et al., 2007, Balakireva et al., 2006, Tomioka et al., 2005, Sun et al., 2002, Preiss et al., 2001, Lemaitre, 2000.12.20, Skolnik, 1999.1.12, Stronach and Perrimon, 1999)
                  TRAF4
                  (Lu et al., 2017, Ríos-Barrera and Riesgo-Escovar, 2013, Pirooznia et al., 2012)
                  Traf1
                  (Cannavò et al., 2016, Sitnik et al., 2016, Griciuc et al., 2014, Japanese National Institute of Genetics, 2012.5.21, Aerts et al., 2010, Kazemian et al., 2010, Carrera et al., 2008, Leptin et al., 2008.2.11, Liu and Lehmann, 2008, Vicente-Crespo et al., 2008, Firth and Baker, 2007, Brandt, 2006, Philippakis et al., 2006, Stroschein-Stevenson et al., 2006, Reeves and Posakony, 2005)
                  Traf4
                  (Sanchez et al., 2019, Sapar and Han, 2019, Zhu et al., 2019, Gene Disruption Project members, 2018-, Gilmour et al., 2017, Transgenic RNAi Project members, 2017-, Lee et al., 2016, Ou et al., 2016, Kavi et al., 2015, Faisal et al., 2014, Huang et al., 2013, Lim and Thiery, 2012, van Bergeijk et al., 2012, Mathew et al., 2011, Ozdemir et al., 2011, Jung et al., 2010, Nechaev et al., 2010, Mathew et al., 2009)
                  dTRAF
                  (Aderem and Ulevitch, 2000)
                  dTRAF1
                  (Wang et al., 2019, Willsey et al., 2016, Tang et al., 2013, Xue et al., 2007, Geuking et al., 2005, Leclerc and Reichhart, 2004, Wu and Arron, 2003, Silverman and Maniatis, 2001, Grech et al., 2000)
                  dTraf1
                  (Zhang et al., 2010, Wasserman, 2000)
                  dTraf4
                  (Djiane et al., 2013)
                  dtraf1
                  (Marchal et al., 2012, Jacinto et al., 2002, Dean and Booker, 2001)
                  traf-1/4
                  (Agrawal et al., 2016)
                  traf-4
                  (Maybeck and Röper, 2009)
                  traf1
                  (Berkey et al., 2009, Mathew et al., 2009)
                  traf1/4
                  (Agrawal et al., 2016)
                  traf4
                  (Kang et al., 2012, Mathew et al., 2009)
                  Name Synonyms
                  TNF Receptor Associated Factor 1
                  (Mathew et al., 2007)
                  TNF receptor associated factor 4
                  (Lu et al., 2017)
                  TNF-receptor associated factor 4
                  (Castillo et al., 2015)
                  TNF-receptor-associated factor 1
                  TNF-receptor-associated factor 4
                  (Faisal et al., 2014, Pirooznia et al., 2012)
                  Secondary FlyBase IDs
                    Datasets (0)
                    Study focus (0)
                    Experimental Role
                    Project
                    Project Type
                    Title
                    References (126)