FlyBase Gene Report: Dmel\Tak1

General Information

Symbol

Dmel\Tak1

Species

D. melanogaster

Name

TGF-β activated kinase 1

Annotation Symbol

CG18492

Feature Type

protein_coding_gene

FlyBase ID

FBgn0026323

Gene Model Status

Current

Stock Availability

27 publicly available

Enzyme Name (EC)

mitogen-activated protein kinase kinase kinase (2.7.11.25)

Gene Summary

TGF-β activated kinase 1 (Tak1) encodes a MAP kinase kinase kinase that functions downstream of the products of imd, Fadd and Diap2. It also functions upstream of the IKK complex in the Imd pathway, a pathway regulating the antibacterial response and other less characterized cellular processes. Upon activation the product of imd, the product of Tak1 can also activate the JNK pathway at the level of the JNK Kinase encoded by bsk in certain cell types. It is also an intracellular signaling component of the Grindelwald-Eiger pathway. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Pathway
Gene Group
UniProtKB
Interactive Fly

Also Known As

dTAK1, dTAK, TAK, dTAK-1, TAK-1

Key Links

Genomic Location

Cytogenetic map

19D2-19D2

Sequence location

X:20,515,908..20,524,928 [-]

Recombination map

1-64

RefSeq locus

NC_004354 REGION:20515908..20524928

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (28 terms)

Molecular Function (7 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

enables JUN kinase kinase kinase activity

inferred from mutant phenotype

(Silverman et al., 2003)

enables MAP kinase kinase kinase activity

inferred from mutant phenotype

(Takatsu et al., 2000)

enables protein binding

inferred from physical interaction with FLYBASE:S6k; FB:FBgn0283472

(Shin et al., 2013)

enables protein serine/threonine kinase activity

inferred from direct assay

(Shen et al., 2022, Chen et al., 2017)

enables ubiquitin protein ligase binding

inferred from physical interaction with FLYBASE:POSH; FB:FBgn0040294

(Tsuda et al., 2005)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables ATP binding

inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR017441

(InterPro Project Members, 2004-)

enables MAP kinase kinase kinase activity

inferred from biological aspect of ancestor with PANTHER:PTN000723805

(GO Reference Genome Project, 2011-)

enables protein kinase activity

inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR001245, InterPro:IPR008271

(InterPro Project Members, 2004-)

Biological Process (20 terms)

Terms Based on Experimental Evidence (18 terms)

CV Term

Evidence

References

involved_in apoptotic process

inferred from genetic interaction with FLYBASE:hid; FB:FBgn0003997

(Takatsu et al., 2000)

inferred from genetic interaction with FLYBASE:rpr; FB:FBgn0011706

(Takatsu et al., 2000)

inferred from genetic interaction with FLYBASE:grim; FB:FBgn0015946

(Takatsu et al., 2000)

involved_in cellular response to lipopolysaccharide

inferred from mutant phenotype

(Ryabinina et al., 2006)

involved_in compound eye development

inferred from mutant phenotype

(Takatsu et al., 2000)

involved_in defense response to Gram-negative bacterium

inferred from mutant phenotype

(Meinander et al., 2012, Leulier et al., 2006)

inferred from genetic interaction with FLYBASE:PGRP-LE; FB:FBgn0030695

(Libert et al., 2006)

involved_in defense response to virus

inferred from mutant phenotype

(Shen et al., 2022, Costa et al., 2009)

involved_in dorsal closure

inferred from mutant phenotype

(Takatsu et al., 2000)

involved_in immune response

inferred from mutant phenotype

(Silverman et al., 2003)

involved_in JNK cascade

inferred from genetic interaction with FLYBASE:bsk; FB:FBgn0000229

(Takatsu et al., 2000)

inferred from genetic interaction with FLYBASE:hep; FB:FBgn0010303

(Takatsu et al., 2000)

inferred from mutant phenotype

(Ryabinina et al., 2006)

involved_in notum morphogenesis

inferred from mutant phenotype

(Mihaly et al., 2001)

involved_in ommatidial rotation

inferred from mutant phenotype

(Mihaly et al., 2001)

involved_in peptidoglycan recognition protein signaling pathway

inferred from mutant phenotype

(Wagner et al., 2021, Chen et al., 2017, Fernando et al., 2014, Meinander et al., 2012, Paquette et al., 2010, Ertürk-Hasdemir et al., 2009, Valanne et al., 2007, Leulier et al., 2006, Silverman et al., 2003, Boutros et al., 2002)

inferred from genetic interaction with FLYBASE:Dredd; FB:FBgn0020381

(Delaney et al., 2006)

inferred from genetic interaction with FLYBASE:trbd; FB:FBgn0037734

(Hua et al., 2022)

inferred from genetic interaction with FLYBASE:Dredd; FB:FBgn0020381,FLYBASE:Fadd; FB:FBgn0038928

(Zhou et al., 2005)

involved_in positive regulation of gene expression

inferred from mutant phenotype

(Srivastava and Dong, 2015)

involved_in positive regulation of JNK cascade

inferred from mutant phenotype

(Silverman et al., 2003)

inferred from genetic interaction with FLYBASE:ben; FB:FBgn0000173,FLYBASE:Uev1A; FB:FBgn0035601

(Ma et al., 2013)

involved_in positive regulation of non-canonical NF-kappaB signal transduction

inferred from mutant phenotype

(Silverman et al., 2003)

acts_upstream_of positive regulation of programmed cell death

inferred from mutant phenotype

(Sun et al., 2019, Ma et al., 2014, Kanda et al., 2011, Xue et al., 2007)

inferred from genetic interaction with FLYBASE:egr; FB:FBgn0033483

(Li et al., 2019, Andersen et al., 2015, Narasimamurthy et al., 2009, Geuking et al., 2005, Igaki et al., 2002)

involved_in regulation of autophagy

inferred from mutant phenotype

(Shin et al., 2013)

involved_in regulation of establishment of planar polarity

inferred from genetic interaction with FLYBASE:pk; FB:FBgn0003090

(Collu et al., 2018)

involved_in tumor necrosis factor-mediated signaling pathway

inferred from genetic interaction with FLYBASE:egr; FB:FBgn0033483

(Li et al., 2019, Andersen et al., 2015, Narasimamurthy et al., 2009, Geuking et al., 2005, Igaki et al., 2002)

inferred from mutant phenotype

(Sun et al., 2019, Ma et al., 2014, Kanda et al., 2011, Zhang et al., 2010, Xue et al., 2007)

inferred from genetic interaction with FLYBASE:ben; FB:FBgn0000173,FLYBASE:Uev1A; FB:FBgn0035601

(Ma et al., 2013)

inferred from genetic interaction with FLYBASE:spoon; FB:FBgn0263987

(Das et al., 2023)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

involved_in immune response

inferred from biological aspect of ancestor with PANTHER:PTN000723805

(GO Reference Genome Project, 2011-)

involved_in JNK cascade

inferred from biological aspect of ancestor with PANTHER:PTN000723805

(GO Reference Genome Project, 2011-)

involved_in positive regulation of antibacterial peptide biosynthetic process

traceable author statement

(Brennan and Anderson, 2004)

involved_in positive regulation of canonical NF-kappaB signal transduction

inferred from biological aspect of ancestor with PANTHER:PTN000723805

(GO Reference Genome Project, 2011-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in cytoplasm

inferred from direct assay

(Stronach et al., 2014)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

NON-RECEPTOR TKL KINASES

Pathway (FlyBase)

IMD SIGNALING PATHWAY CORE COMPONENTS

TNFalpha-EIGER SIGNALING PATHWAY CORE COMPONENTS

Protein Family (UniProt)

Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (Q9V3Q6)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

MAP kinase kinase kinase activity

(1) L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+) (2.7.11.25)

(2) L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+) (2.7.11.25)

Summaries

Gene Snapshot

Gene Group (FlyBase)

NON-RECEPTOR TKL KINASES -: Non-receptor tyrosine kinase-like (TKL) kinases are a diverse group of intracellular serine-threonine protein kinases with sequence similarity to tyrosine kinases (TK) but lacking TK-specific motifs.

Pathway (FlyBase)

IMD SIGNALING PATHWAY CORE COMPONENTS -: The immune deficiency (Imd) pathway primarily mediates the humoral immune response to Gram-negative bacteria. Activation of the Imd pathway by diaminopimelic acid-type peptidoglycan initiates a signaling cascade that ultimately results in the release of the NFκB-like factor Rel from auto-inhibition and its translocation into the nucleus to activate the transcription of antimicrobial peptides. (Adapted from FBrf0224587 and FBrf0238555.)
TNFalpha-EIGER SIGNALING PATHWAY CORE COMPONENTS -: The Tumor Necrosis Factor α (TNFα) signaling pathway is activated by Eiger (egr) binding to a member of the TNF receptor superfamily. The signal is primarily transduced via the Jun N-terminal kinase (JNK) cascade, leading to cell death. (Adapted from FBrf0225608.)

Protein Function (UniProtKB)

Component of a protein kinase signal transduction cascade. Mediator of TGF-beta signal transduction. Responsible for activation of the JNK MAPK pathway (basket, bsk and hemipterous, hep) in response to LPS. Component of the NF-kappa-B pathway; relish-mediated JNK inhibition involves proteasomal degradation of Tak1; certain targets of Relish that are induced during immune responses may facilitate destruction of Tak1 and switch off the JNK cascade. Participates in diverse roles such as control of cell shape and regulation of apoptosis.

(UniProt, Q9V3Q6)

Summary (Interactive Fly)

is a MAP kinase kinase kinase required for morphogenetic changes that take place during the fusion of the epithelial wing disc cell layers (thoracic closure), acting in the context of JNK signaling - required for Relish cleavage and antibacterial immunity - functions downstream of imd, Fadd and Diap2 and upstream of the IKK complex in the Imd pathway

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Tak1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9V3Q6)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.50

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Tak1-RA

FBtr0077319

NM_079356

3391

678

Tak1-RB

FBtr0340404

NM_001298569

1650

258

Additional Transcript Data and Comments

Reported size (kB)

3.4 (longest cDNA)

(Takatsu et al., 2000)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Tak1-PA

FBpp0077011

75.7

678

5.06

FBpp0309350

29.4

258

4.79

X2JFZ3

NP_001285498

AHN59968

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

678 (aa)

(Takatsu et al., 2000)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Tak1 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.53

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 13 -- 16

organism | ubiquitous

(Fisher et al., 2012)

RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult Malpighian tubule

(McGettigan et al., 2005)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in cytoplasm

inferred from direct assay

(Stronach et al., 2014)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Tak1 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Tak1

View exonic expression by tissue for Dmel\Tak1

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0026323

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

39659/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0026323

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0026323

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0026323

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG18492

Flygut - An atlas of the Drosophila adult midgut

FBgn0026323

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 11 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 28 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Tak1

Transgenic constructs containing regulatory region of Tak1

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 14 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^unspecified

Tak1^UAS.cMa

lethal - all die before end of pupal stage, with Scer\GAL4^GMR.PF

lethal - all die during embryonic stage, with Scer\GAL4^GMR.PU

Tak1^{Ct.UASp.Tag:HA}

lethal - all die during larval stage | nutrition conditional, with Scer\GAL4^Tub.PU

Tak1^KK108611

lethal - all die during P-stage, with Scer\GAL4^Tub.PU

Tak1^KK108611

lethal - all die during pupal stage, with Scer\GAL4^GMR.PF

Tak1^UAS.cMa

lethal - all die during pupal stage, with Scer\GAL4^sev.EP

Tak1^UAS.cMa

partially lethal - majority die, with Scer\GAL4^Bx-MS1096

Tak1^UAS.cMa

partially lethal - majority die, with Scer\GAL4^GMR.PF

Tak1^UAS.cTa

viable

viable, with Scer\GAL4^sev.EP

Tak1^UAS.cMa

Sterility

Allele

female semi-sterile, with Scer\GAL4^{VP16.mat.αTub67C}

female semi-sterile, with Scer\GAL4^{VP16.nanos.UTR}, Scer\GAL4^VP16.otu, Scer\GAL4^nanos.PG

Other Phenotypes

Allele

abnormal immune response

abnormal immune response, with Scer\GAL4^da.G32

Tak1^K46R.M.UAS

abnormal immune response, with Scer\GAL4^hs.PB

Tak1^NIG.1388R

abnormal immune response, with Scer\GAL4^yolk

Tak1^NIG.1388R

abnormal immune response, with Tak1²

Tak1^K46R.M.UAS

abnormal immune response, with Tak1^K46R.M.UAS

Tak1²

abnormal immune response | adult stage

Tak1²

abnormal immune response | adult stage, with Scer\GAL4^r4

Tak1^KK108611

abnormal immune response | recessive

Tak1²

abnormal neuroanatomy, with Scer\GAL4^nSyb.PS

Tak1^UAS.cMa

abnormal neuroanatomy | larval stage, with Scer\GAL4^wor.PA

Tak1^UAS.cTa

abnormal neuroanatomy | third instar larval stage

abnormal neurophysiology | third instar larval stage

abnormal neurophysiology | third instar larval stage, with Scer\GAL4^VGlut1-OK371

Tak1^{K46R.UAS.Tag:FLAG}

abnormal neurophysiology | third instar larval stage (with Df(1)BSC645)

Tak1²

abnormal neurophysiology | third instar larval stage (with Tak1²)

Tak1¹⁷⁹

abnormal neurophysiology | third instar larval stage (with Tak1¹⁷⁹)

Tak1²

abnormal planar polarity, with Scer\GAL4^hs.2sev

Tak1^UAS.cMa

abnormal size, with Scer\GAL4^GMR.PF

Tak1^UAS.cUa

abnormal size | adult stage, with Scer\GAL4^Bx-MS1096

Tak1^UAS.cMa

decreased cell death | embryonic stage, with Scer\GAL4^Act5C.PU

Tak1^K46R.UAS

decreased cell death | embryonic stage, with Scer\GAL4^how-24B

Tak1^K46R.UAS

decreased occurrence of cell division | embryonic stage 13 | conditional

Tak1²

increased cell death, with Scer\GAL4^GMR.PF

Tak1^UAS.cTa

increased cell death, with Scer\GAL4^hs.2sev

Tak1^UAS.cMa

increased cell death, with Scer\GAL4^sev.PU

Tak1^UAS.cMa

increased cell death | embryonic stage, with Scer\GAL4^Act5C.PU

Tak1^UAS.cTa

increased cell death | embryonic stage, with Scer\GAL4^how-24B

Tak1^UAS.cTa

increased mortality

Tak1²

increased mortality | conditional

Tak1²⁵²⁷

majority die during pupal stage, with Scer\GAL4^Bx-MS1096

Tak1^UAS.cMa

some die during larval stage, with Scer\GAL4^Tub.PU

Tak1^KK108611

some die during pupal stage, with Scer\GAL4^GMR.PF

visible, with Scer\GAL4^GMR.PF

visible, with Scer\GAL4^hs.2sev

Tak1^UAS.cMa

visible, with Scer\GAL4^pnr-MD237

Tak1^K46R.UAS

visible, with Scer\GAL4^sev.PU

Tak1^UAS.cMa

visible, with Scer\GAL4^yolk

Tak1^UAS.cMa

visible | adult stage, with Scer\GAL4^Bx-MS1096

Tak1^UAS.cMa

visible | adult stage, with Scer\GAL4^sev.EP

Tak1^UAS.cMa

wild-type

Tak1^+t15

wild-type, with Scer\GAL4^arm.PS

wild-type, with Scer\GAL4^en-e16E

Phenotype manifest in

Allele

abdominal segment motor neuron | third instar larval stage

abdominal segment motor neuron | third instar larval stage, with Scer\GAL4^VGlut1-OK371

Tak1^{K46R.UAS.Tag:FLAG}

abdominal segment motor neuron | third instar larval stage (with Df(1)BSC645)

Tak1²

abdominal segment motor neuron | third instar larval stage (with Tak1²)

Tak1¹⁷⁹

abdominal segment motor neuron | third instar larval stage (with Tak1¹⁷⁹)

Tak1²

adult fat body, with Scer\GAL4^yolk

Tak1^UAS.cMa

adult thorax, with Scer\GAL4^Bx-MS1096

Tak1^UAS.cMa

basement membrane, with Scer\GAL4^ptc-559.1

Tak1^UAS.cMa

denticle row 1, with Scer\GAL4^prd.RG1

Tak1^UAS.cTa

embryo, with Scer\GAL4^pnr-MD237

Tak1^K46R.UAS

embryo | anterior, with Scer\GAL4^pnr-MD237

Tak1^K46R.UAS

embryonic/first instar larval cuticle | dorsal, with Scer\GAL4^pnr-MD237

Tak1^K46R.UAS

embryonic/larval neuromuscular junction | third instar larval stage

embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4^nSyb.PS

Tak1^UAS.cMa

embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4^VGlut1-OK371

Tak1^{K46R.UAS.Tag:FLAG}

embryonic/larval neuromuscular junction | third instar larval stage (with Df(1)BSC645)

Tak1²

embryonic/larval neuromuscular junction | third instar larval stage (with Tak1²)

Tak1¹⁷⁹

embryonic/larval neuromuscular junction | third instar larval stage (with Tak1¹⁷⁹)

Tak1²

embryonic head, with Scer\GAL4^pnr-MD237

Tak1^K46R.UAS

eye, with Scer\GAL4^GMR.PF

eye, with Scer\GAL4^hs.2sev

Tak1^UAS.cMa

eye, with Scer\GAL4^sev.EP

Tak1^UAS.cMa

eye, with Scer\GAL4^sev.PU

Tak1^UAS.cMa

eye disc, with Scer\GAL4^GMR.PF

Tak1^UAS.cTa

eye disc, with Scer\GAL4^hs.2sev

Tak1^UAS.cMa

eye disc, with Scer\GAL4^sev.PU

Tak1^UAS.cMa

eye photoreceptor cell, with Scer\GAL4^hs.2sev

Tak1^UAS.cMa

interommatidial bristle, with Scer\GAL4^GMR.PF

Tak1^K46R.UAS

mesonotum, with Scer\GAL4^ap-md544

mesonotum, with Scer\GAL4^pnr-MD237

microchaeta, with Scer\GAL4^ap-md544

microchaeta, with Scer\GAL4^pnr-MD237

mouth hook, with Scer\GAL4^pnr-MD237

Tak1^K46R.UAS

neuroblast | larval stage, with Scer\GAL4^wor.PA

Tak1^UAS.cTa

NMJ bouton | third instar larval stage, with Scer\GAL4^nSyb.PS

Tak1^UAS.cMa

ommatidium, with Scer\GAL4^hs.2sev

Tak1^UAS.cMa

photoreceptor neuron, with Scer\GAL4^GMR.PF

Tak1^UAS.cTa

presynaptic active zone

Tak1²

pupa, with Scer\GAL4^GMR.PF

Tak1^UAS.cTa

secondary pigment cell, with Scer\GAL4^GMR.PF

Tak1^K46R.UAS

synapse | third instar larval stage, with Scer\GAL4^nSyb.PS

Tak1^UAS.cMa

synaptic vesicle

synaptic vesicle, readily releasable pool

Tak1²

tertiary pigment cell, with Scer\GAL4^GMR.PF

Tak1^K46R.UAS

type I bouton | third instar larval stage

ventral denticle belt, with Scer\GAL4^prd.RG1

Tak1^UAS.cTa

ventral midline of embryo | embryonic stage 13 | conditional

Tak1²

wing, with Scer\GAL4^Bx-MS1096

Tak1^UAS.cMa

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (84)

Hsap\MAP3K7

9 of 14

Yes

Hsap\ANKK1

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Hsap\RIPK4

2 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (45)

Rnor\Map3k7

9 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Rnor\Ripk4

2 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Bmx

1 of 14

Rnor\Cdkl2

1 of 14

Rnor\Dstyk

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (47)

Mmus\Map3k7

8 of 14

Yes

Mmus\Ankk1

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Mmus\Ripk4

2 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (35)

Xtro\map3k7

8 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\ripk4

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (60)

Drer\map3k7

8 of 14

Yes

Drer\ankk1

2 of 14

Yes

Drer\LOC405768

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\ros1

1 of 14

Drer\si:ch211-45c16.2

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (21)

Cele\mom-4

6 of 14

Yes

Cele\Y105C5A.24

6 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (20)

Agam\AgaP_AGAP013516

9 of 12

Yes

3 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (81)

Atha\AT3G50720

5 of 13

Yes

Atha\AT3G50730

5 of 13

Yes

Atha\AT5G66710

5 of 13

Yes

4 of 13

4 of 13

4 of 13

4 of 13

Yes

Atha\AT5G40540

4 of 13

Yes

Atha\AT5G50000

4 of 13

Atha\AT5G50180

4 of 13

Yes

Atha\ATN1

4 of 13

Yes

Atha\AT2G24360

3 of 13

Atha\AT3G46930

3 of 13

Atha\AT4G23050

3 of 13

Yes

3 of 13

3 of 13

3 of 13

3 of 13

2 of 13

Yes

Atha\AT1G04700

2 of 13

Yes

Atha\AT1G16270

2 of 13

Yes

Atha\AT1G18160

2 of 13

Atha\AT1G64300

2 of 13

Yes

Atha\AT1G67890

2 of 13

Atha\AT1G73660

2 of 13

Atha\AT1G79570

2 of 13

Yes

Atha\AT2G31010

2 of 13

Atha\AT2G31800

2 of 13

Atha\AT2G35050

2 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

Yes

Atha\AT3G46920

2 of 13

Yes

Atha\AT3G58640

2 of 13

Atha\AT3G58760

2 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

Yes

Atha\AT1G19390

1 of 13

Yes

Atha\AT1G24030

1 of 13

Atha\AT1G61550

1 of 13

Yes

Atha\AT1G78940

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\AT5G49470

1 of 13

Atha\AT5G56890

1 of 13

Atha\AT5G57035

1 of 13

Yes

Atha\AT5G58520

1 of 13

Atha\AT5G59670

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\WAKL6

1 of 13

Yes

Atha\YDA

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (2)

Scer\ARK1

1 of 13

Yes

Scer\CDC15

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\byr1

1 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Tak1. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (29)

Takl2

7 of 13

Takl1

6 of 13

slpr

5 of 13

Mos

4 of 13

wnd

3 of 13

CG8173

2 of 13

ksr

2 of 13

LIMK1

2 of 13

Lrrk

2 of 13

Raf

2 of 13

Alk

1 of 13

Ask1

1 of 13

Atg1

1 of 13

babo

1 of 13

cdi

1 of 13

CG41099

1 of 13

Fak

1 of 13

FER

1 of 13

fray

1 of 13

hop

1 of 13

htl

1 of 13

Ilk

1 of 13

InR

1 of 13

PKD

1 of 13

put

1 of 13

sax

1 of 13

Src64B

1 of 13

tkv

1 of 13

wit

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

MAP3K7; mitogen-activated protein kinase kinase kinase 7

model of frontometaphyseal dysplasia 2

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 7 )

Allele

Disease

Interaction

References

Tak1^HMS00282

ameliorates lower respiratory tract disease

modeled by PGRP-LC^x.UAS

(Wagner et al., 2021)

Tak1¹

ameliorates cancer

modeled by Ras85D^V12.UAS, Tace^RNAi.UAS.cSa

(Chabu and Xu, 2014)

Tak1^K46R.M.UAS

ameliorates lower respiratory tract disease

modeled by PGRP-LC^x.UAS

(Wagner et al., 2021)

Tak1^K46R.UAS

ameliorates cancer

modeled by Ras85D^V12.UAS, fmt¹

(Ma et al., 2017)

modeled by Ras85D^V12.UAS, PpV^Δ1

(Ma et al., 2017)

Tak1^NIG.1388R

exacerbates carcinoma

modeled by Ras85D^V12.UAS, l(2)gl⁴

(Igaki et al., 2006)

Tak1^UAS.cUa

ameliorates cancer

modeled by Alk^UAS.cLa

(Wolfstetter et al., 2020)

Tak1^KK108611

ameliorates human immunodeficiency virus infectious disease

modeled by HIV-1\Vpu^UAS.cLa

(Marchal et al., 2012)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

MAP3K7; mitogen-activated protein kinase kinase kinase 7

9 of 14

602614

frontometaphyseal dysplasia 2

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Tak1 - Atg8a

two hybrid, pull down, anti tag western blot

(Tsapras et al., 2022)

Tak1 - Mkk4

anti tag coimmunoprecipitation, anti tag western blot

(Geuking et al., 2009)

Tak1 - POSH

pull down, autoradiography, anti bait coimmunoprecipitation, anti tag western blot

(Tsuda et al., 2005)

Tak1 - Slmap

anti tag coimmunoprecipitation, anti tag western blot, pull down, western blot

(Shen et al., 2022)

Tak1 - Tab2

anti tag coimmunoprecipitation, anti tag western blot

(Geuking et al., 2005)

Tak1 - Tlk

anti bait coimmunoprecipitation, western blot

(Liaw and Chiang, 2019)

Tak1 - Traf4

anti tag coimmunoprecipitation, anti tag western blot

(Geuking et al., 2005)

Tak1 - Traf6

anti tag coimmunoprecipitation, anti tag western blot

(Geuking et al., 2005)

Tak1 - alph

anti tag coimmunoprecipitation, western blot

(Baril et al., 2009)

Tak1 - eIF3f1

anti tag coimmunoprecipitation, anti tag western blot

(Hu et al., 2024)

Tak1 - imd

enzymatic study, anti tag western blot, autoradiography, inferred by author

(Shen et al., 2022, Chen et al., 2017)

Tak1 - trbd

anti tag coimmunoprecipitation, anti tag western blot, pull down, anti bait coimmunoprecipitation, western blot

(Hua et al., 2022, Fernando et al., 2014)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Tak1

suppressible

bsk

(Yang and Su, 2011, Xue et al., 2007, Mihaly et al., 2001, Takatsu et al., 2000)

Tak1

enhanceable

GluRIIA

(Harris et al., 2018)

Tak1

suppressible

hep

(Xue et al., 2007, Mihaly et al., 2001, Takatsu et al., 2000)

Tak1

suppressible

Jra

(Mihaly et al., 2001)

Tak1

suppressible

lncRNA:Hsrω

(Mallik and Lakhotia, 2009)

Tak1

enhanceable

lncRNA:Hsrω

(Mallik and Lakhotia, 2009)

Tak1

suppressible

msn

(Mihaly et al., 2001)

Tak1

suppressible

nmo

(Mihaly et al., 2001)

Tak1

suppressible

p53

(Yang and Su, 2011)

Tak1

enhanceable

S6k

(Shin et al., 2013)

Tak1

suppressible

S6k

(Shin et al., 2013)

suppressible

(Das et al., 2023)

suppressible

(Srivastava et al., 2007)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

arm

suppressible

Tak1

(McEwen et al., 2000)

arm

enhanceable

Tak1

(McEwen et al., 2000)

suppressible

(Ma et al., 2014)

suppressible

(Ma et al., 2013)

suppressible

(Xue et al., 2007)

suppressible

(Yang and Su, 2011)

egr

suppressible

Tak1

(Andersen et al., 2015, Stronach et al., 2014, Ma et al., 2012, Narasimamurthy et al., 2009, Polaski et al., 2006, Geuking et al., 2005, Igaki et al., 2002)

suppressible

(Ma et al., 2017)

suppressible

(Seisenbacher et al., 2011)

nmo

suppressible

Tak1

(Mirkovic et al., 2002)

nmo

enhanceable

Tak1

(Mirkovic et al., 2002)

PGRP-LE

suppressible

Tak1

(Libert et al., 2006)

PGRP-LF

suppressible

Tak1

(Maillet et al., 2008)

POSH

suppressible

Tak1

(Zhang et al., 2010)

puc|Moe

suppressible

Tak1

(Neisch et al., 2010)

Rab8

suppressible

Tak1

(West et al., 2015)

Rab11

enhanceable

Tak1

(Tiwari and Roy, 2009)

suppressible

(Wu et al., 2009)

suppressible

(Igaki et al., 2006)

suppressible

(Ma et al., 2017)

suppressible

(Ma et al., 2017)

suppressible

(Yang and Su, 2011)

Rho1

suppressible

Tak1|slpr

(Neisch et al., 2010)

RpS3|yki

suppressible

Tak1

(Wada et al., 2021)

slpr

enhanceable

Tak1

(Stronach et al., 2014, Polaski et al., 2006)

Strip

suppressible

Tak1

(La Marca et al., 2019)

Syx7

suppressible

Tak1

(Andersen et al., 2015)

suppressible

(Cha et al., 2003)

enhanceable

(Cha et al., 2003)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

64981

DroID - A comprehensive database of gene and protein interactions.

FBgn0026323

MIST (genetic) - An integrated Molecular Interaction Database

39659

MIST (protein-protein) - An integrated Molecular Interaction Database

39659

Pathways

Signaling Pathways (FlyBase)

IMD SIGNALING PATHWAY CORE COMPONENTS
TNFalpha-EIGER SIGNALING PATHWAY CORE COMPONENTS

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q9V3Q6

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-64

Cytogenetic map

19D2-19D2

Sequence location

X:20,515,908..20,524,928 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

19D2-19D2

Limits computationally determined from genome sequence between P{EP}CG1702^EP1525 and P{EP}EP1465&P{EP}CG1486^EP1192

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

19E5-19E7

(Takatsu, 1999.10.28)

19E1-19E4

(O'Connor, 1999.3.4)

Experimentally Determined Recombination Data

Location

1-64

(FlyBase, 2016)

1-64.6

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (27)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

58809

Tak1²⁵²⁷

26275

w^* Tak1¹⁷⁹

58810

w^*; P{UAS-Tak1.M}T8

59003

w^*; P{UASp-Tak1.Ct-HA}1

59004

w^*; P{UASp-Tak1.Ct-HA}7

97226

w¹¹¹⁸ Tak1^LIR1

58811

w^*; P{UAS-Tak1.K46R.M}T4/CyO

1388R-1

1388R-2

v330457

v101357

v318795

PBac{fTRG01197.sfGFP-TVPTBF}VK00002

More stocks available...

Genomic Clones (16)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (38)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD42274

Other clones

DPiM_LD42274

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0026323

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0026323

Antibody Information

Laboratory Generated Antibodies

monoclonal

(Tsapras et al., 2022)

polyclonal

(Stronach et al., 2014, Paquette et al., 2010)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Tak1 regulates autophagic cell death.

(Shin et al., 2013)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Identified as a gene with significant level of mRNA cycling as assessed by expression analysis using high density oligonucleotide arrays with probe generated from adult heads harvested over six time points over the course of a day. Shows alteration in expression in a Clk mutant background.

(McDonald and Rosbash, 2001)

Tak1 appears not to be strictly required for dorsal closure during embryogenesis. Tak1 is involved in ommatidial planar polarity signalling in the eye and thorax closure.

(Mihaly et al., 2001)

Tak1 has a role in activation of Rel/NF-κB-mediated host defence reactions.

(Vidal et al., 2001)

Tak1 functions as a MAPKKK in the JNK signalling pathway and participates in such diverse roles as control of cell shape and regulation of apoptosis.

(Takatsu et al., 2000)

The JNK signalling pathway is specifically activated by Tak1 signalling.

(Nakamura et al., 1999)

Ectopic expression of Tak1 in the eye leads to a small eye phenotype due to ectopically induced apoptosis.

(Nakamura et al., 1999)

Relationship to Other Genes

Source for database merge of

Source for merge of: Tak1 CG1388

(Millburn, 2000.4.12)

Source for merge of: Tak1 CG18492

(FlyBase, 1996-)

Additional comments

Source for merge of Tak1 CG18492 was sequence comparison ( date:001104 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (30)

Reported As

Symbol Synonym

CG1388

(Millburn, 2000.4.12)

CG18492

(Meadows, 2018.4.4, Ni et al., 2011.7.19, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Ni et al., 2008, Morrison et al., 2000)

D-TAK

(Ryabinina et al., 2006)

D-tak

(Kockel et al., 2001)

D10

(Vidal et al., 2001)

DTAK1

(Wu et al., 2009, Govind and Nehm, 2004, Cha et al., 2003, Danos et al., 1999, Nakamura et al., 1999)

DTak

(McEwen et al., 2000)

DTak1

(McEwen et al., 2000)

DmTak1

(Zsindely et al., 2009, Lemaitre, 2000.12.20)

TAK

(Garcia et al., 2024, Seisenbacher et al., 2011, Libert et al., 2006, Agaisse et al., 2003, Jasper and Bohmann, 2002, Morrison et al., 2000)

TAK-1

(Nayak and Mishra, 2022, Yeo and Gautier, 2004)

TAK1

(Li et al., 2025, Rai and Bergmann, 2024, Wang et al., 2024, Bossen et al., 2023, Li et al., 2023, Li et al., 2023, Cammarata-Mouchtouris et al., 2022, Cheung et al., 2022, Lu and Chtarbanova, 2022, Shen et al., 2022, Yu et al., 2022, Gan et al., 2021, Salem Wehbe et al., 2021, Sciambra and Chtarbanova, 2021, Sharma et al., 2021, Wagner et al., 2021, Yu et al., 2021, Palmer et al., 2020, Tafesh-Edwards and Eleftherianos, 2020, Galenza and Foley, 2019, Kounatidis and Chtarbanova, 2018, Min and Tatar, 2018, Shahrestani et al., 2018, Zhai et al., 2018, Mussabekova et al., 2017, West et al., 2015, Fernando et al., 2014, Imler, 2014, Kleino and Silverman, 2014, Myllymäki et al., 2014, Aparicio et al., 2013, Ayyaz and Jasper, 2013, Ferrandon, 2013, Fukuyama et al., 2013, Ríos-Barrera and Riesgo-Escovar, 2013, Shin et al., 2013, Bier and Guichard, 2012, Eleftherianos and Castillo, 2012, Kounatidis and Ligoxygakis, 2012, Papatheodorou et al., 2012, Vandenabeele and Bertrand, 2012, Biteau et al., 2011, Paquette et al., 2010, Ryu et al., 2010, Ertürk-Hasdemir et al., 2009, Bond et al., 2008, Ryu et al., 2008, Avet-Rochex et al., 2007, Ferrandon et al., 2007, Waterhouse et al., 2007, Delaney et al., 2006, Kim et al., 2006, Libert et al., 2006, Zaidman-Remy et al., 2006, Gesellchen et al., 2005, Tsuda et al., 2005, Hoffmann, 2003, Aigaki et al., 2002, Takatsu, 1999.10.28)

Tak

(Sathyanarayanan et al., 2008)

Tak 1

(Peifer, 1999)

Tak1

(Qin et al., 2025, Balakireva et al., 2024, Hu et al., 2024, Kodra et al., 2024, Meyer et al., 2024, Nigg et al., 2024, Sharmin et al., 2024, Wang et al., 2024, Zeng et al., 2024, Zhou et al., 2024, Das et al., 2023, Hsieh and Chiang, 2023, Mouawad et al., 2023, Shu et al., 2023, Stączek et al., 2023, Benoit et al., 2022, Havula et al., 2022, Shen et al., 2022, Tsapras and Nezis, 2022, Xu et al., 2022, Buhlman et al., 2021, Fabian et al., 2021, Harnish et al., 2021, Ozakman and Eleftherianos, 2021, Rosendo Machado et al., 2021, Zhu et al., 2021, Barata and Dick, 2020, Cui et al., 2020, Krautz et al., 2020, La Marca and Richardson, 2020, Li et al., 2020, Younes et al., 2020, Asri et al., 2019, Ji et al., 2019, La Marca et al., 2019, Lee et al., 2019, Liaw and Chiang, 2019, Mishra-Gorur et al., 2019, Sanchez et al., 2019, Yang et al., 2019, Yang et al., 2019, Behrman et al., 2018, Gene Disruption Project members, 2018-, Harris et al., 2018, Richardson and Portela, 2018, Aggarwal et al., 2017, Chen et al., 2017, Christesen et al., 2017, Early et al., 2017, Muzzopappa et al., 2017, Tavignot et al., 2017, Liu et al., 2016, Padash Barmchi et al., 2016, Sarov et al., 2016, Schimizzi et al., 2016, Zhang et al., 2016, Andersen et al., 2015, Di Cara et al., 2015, Sansone et al., 2015, Vedanayagam and Garrigan, 2015, Woodcock et al., 2015, Chabu and Xu, 2014, Keebaugh and Schlenke, 2014, Kuang et al., 2014, Schulman et al., 2014, Sopko et al., 2014, Stronach et al., 2014, Wong et al., 2014, Buchon et al., 2013, Carter, 2013, Clark et al., 2013, Gendrin et al., 2013, Macdonald et al., 2013, Ma et al., 2012, Meinander et al., 2012, Papatheodorou et al., 2012, Alic et al., 2011, Clark et al., 2011, Friedman et al., 2011, Toku et al., 2011, Valanne et al., 2011, Chen et al., 2010, Hill-Burns and Clark, 2010, Kim et al., 2010, Lennox and Stronach, 2010, Lesch et al., 2010, Neisch et al., 2010, Valanne et al., 2010, Yukilevich et al., 2010, Baril et al., 2009, Costa et al., 2009, Geuking et al., 2009, Hill-Burns and Clark, 2009, Thevenon et al., 2009, Davis et al., 2008, Maillet et al., 2008, Ryu et al., 2008, Beltran et al., 2007, Busse et al., 2007, Pham et al., 2007, Valanne et al., 2007, Friedman and Perrimon, 2006, Leulier et al., 2006, Libert et al., 2006, Polaski et al., 2006)

dTAK

(Luo et al., 2019, Collu et al., 2018, Domingues and Ryoo, 2008, Copeland et al., 2007, Brennan and Anderson, 2004, Igaki et al., 2002, Stronach and Perrimon, 2002)

dTAK-1

(Luo et al., 2019, Jones et al., 2008, Srivastava et al., 2007)

dTAK1

(Khan et al., 2023, Loudhaief et al., 2023, Singh and Tapadia, 2022, Wang et al., 2022, Herrera and Bach, 2021, Mishra et al., 2021, Sun et al., 2019, Sun et al., 2019, Wang et al., 2019, Wu et al., 2019, Ahmed-de-Prado and Baonza, 2018, Dutta et al., 2018, Goto et al., 2018, Hori et al., 2018, Palmer et al., 2018, Zhai et al., 2018, Ma et al., 2017, Ma et al., 2016, Wu et al., 2015, Chabu and Xu, 2014, Ma et al., 2014, Xu and Cherry, 2014, Kingsolver et al., 2013, Merkling and van Rij, 2013, Nelson et al., 2013, Shin et al., 2013, Igboin et al., 2012, Marchal et al., 2012, Kanda et al., 2011, Seisenbacher et al., 2011, Yang and Su, 2011, Sabin et al., 2010, Zhang et al., 2010, Bond and Foley, 2009, Mallik and Lakhotia, 2009, Narasimamurthy et al., 2009, Bergeret et al., 2008, Bond et al., 2008, Jones et al., 2008, Malagoli et al., 2008, Sekiya et al., 2008, Bidla et al., 2007, Kuranaga and Miura, 2007, Srivastava et al., 2007, Tsichritzis et al., 2007, Wu and Silverman, 2007, Xue et al., 2007, Akira et al., 2006, Delaney et al., 2006, Igaki et al., 2006, Igaki et al., 2006, Libert et al., 2006, Zhuang et al., 2006, Delaney et al., 2005, Geuking et al., 2005, Paquette et al., 2005, Zhou et al., 2005, Craig et al., 2004, Leclerc and Reichhart, 2004, Agaisse et al., 2003, Silverman et al., 2003, Zhou et al., 2003, Khush et al., 2002, Leulier et al., 2002, Mihaly et al., 2001, Mushegian and Medzhitov, 2001, Silverman and Maniatis, 2001, Vidal et al., 2001, Vidal et al., 2001, Takatsu et al., 2000)

dTak

(Fiehler and Wolff, 2008, Wu et al., 2007)

dTak1

(Hu et al., 2024, Kietz and Meinander, 2023, Williams et al., 2023, Chi et al., 2018, Aggarwal et al., 2016, Verma and Tapadia, 2015, Ma et al., 2013, Ma et al., 2013, Bangi et al., 2012, Bier and Guichard, 2012, Igboin et al., 2012, Radyuk et al., 2010, Tiwari and Roy, 2009, Orr et al., 2008, Huh et al., 2007, McGettigan et al., 2005, Khush et al., 2002, Dan et al., 2001)

dtak1

(Chabu and Xu, 2014, Radyuk et al., 2010, Zhang et al., 2010)

tak

(Boutros et al., 2002)

tak1

(Palmerini et al., 2021, Rajasekaran et al., 2021, Wada et al., 2021, Wagner et al., 2021, Frank et al., 2020, Ahlers et al., 2019, Boulan et al., 2019, Ji et al., 2019, Mondal et al., 2018, Park et al., 2004, Kurz and Ewbank, 2003, Jasper et al., 2001)

Name Synonyms

TGF β-activated kinase 1

(Fukuyama et al., 2013)

TGF-beta activated-kinase 1

(Takatsu, 1999.10.28)

TGF-β activated kinase 1

(Kim et al., 2010, Nakamura et al., 1999)

TGFβ-activated kinase 1

(Delaney et al., 2006)

Transforming growth factor beta-activated kinase

(Kuang et al., 2014)

transforming growth factor-β activated kinase 1

(Shin et al., 2013)

transforming growth factor-β-activated kinase 1

(Gesellchen et al., 2005)

Secondary FlyBase IDs

FBgn0031120
FBgn0042230

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 56 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

39659

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9V3Q6

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9V3Q6

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

X2JFZ3

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9V3Q6

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0026323

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

39659/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0026323

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0026323

FlyMine - An integrated database for Drosophila genomics

FBgn0026323

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG18492

MARRVEL_MODEL - MARRVEL (model organism gene)

39659

Linkouts

BioGRID - A database of protein and genetic interactions.

64981

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0026323

DroID - A comprehensive database of gene and protein interactions.

FBgn0026323

DRSC - Results frm RNAi screens

FBgn0026323

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0026323

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0026323

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG18492

Flygut - An atlas of the Drosophila adult midgut

FBgn0026323

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC005572

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

MIST (genetic) - An integrated Molecular Interaction Database

39659

MIST (protein-protein) - An integrated Molecular Interaction Database

39659

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q9V3Q6

References (363)

The following external sites may use different assemblies or annotations than FlyBase.

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