dTAK1, dTAK, TAK, dTAK-1, DmTak1
is a MAP kinase kinase kinase required for morphogenetic changes that take place during the fusion of the epithelial wing disc cell layers (thoracic closure), acting in the context of JNK signaling - required for Relish cleavage and antibacterial immunity - functions downstream of imd, Fadd and Diap2 and upstream of the IKK complex in the Imd pathway
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.50
None of the polypeptides share 100% sequence identity.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Tak1 using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Tak1 in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
Identified as a gene with significant level of mRNA cycling as assessed by expression analysis using high density oligonucleotide arrays with probe generated from adult heads harvested over six time points over the course of a day. Shows alteration in expression in a Clk mutant background.
Tak1 functions as a MAPKKK in the JNK signalling pathway and participates in such diverse roles as control of cell shape and regulation of apoptosis.