binds the PP1c phosphatase and its regulator Sds22 - both Notch and Delta traffic through Sara endosomes - involved in signalling bias between the pIIa-pIIb sibling cells - Sara endosomes are specifically targeted to the pIIa cell during sensory organ precursor division, mediating the transport of a pool of Notch and Delta that contribute to the activation of Notch in the pIIa - Uninflatable controls the asymmetric dispatch of the Sara endosomes
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.51
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Sara using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Sara in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.