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Gene Dmel\Sara

General Information
Symbol	Dmel\Sara	Species	D. melanogaster
Name	Smad anchor for receptor activation	Annotation symbol	CG15667
Feature type	protein_coding_gene	FlyBase ID	FBgn0026369
Gene Model Status	Current	Stock availability	6 publicly available
Also Known As	dSARA
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	57E6-57E6	Sequence location	2R:17,369,432..17,374,612 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Smad anchor for receptor activation is referred to in FlyBase by the symbol Dmel\Sara (CG15667, FBgn0026369). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein phosphatase 1 binding. It is reported to be involved in the biological process: transforming growth factor beta receptor signaling pathway; protein localization. 12 alleles are reported. The phenotypes of these alleles are annotated with: wing vein L5; posterior crossvein; wing disc; wing vein; triple row. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Domain of unknown function DUF3480; Smad anchor for receptor activation, Smad-binding domain; Zinc finger, FYVE-related; Zinc finger, FYVE-type; Zinc finger, FYVE-type, SARA/endofin; Zinc finger, FYVE/PHD-type; Zinc finger, RING/FYVE/PHD-type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, larval salivary gland, larval trachea, adult female reproductive system, adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1639858_s_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of Sara. Gene sequence location is 2R:17369424..17374618.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 57E6-57E6   Limits computationally determined from genome sequence between P{PZ}tmx1&P{EP}MESK2EP2347 and P{PZ}Egfr05351
Experimentally Determined Cytological Location
Cytogenetic map Notes References 57E1-57E1     (Martin, 2000.3.1) 57E1-57E2     (Martin et al., 1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Sara for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Low-frequency RNA-Seq exon junction(s) not annotated. Gene model reviewed during 5.51
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Sara-RA FBtr0071641  NM_079990   4621   1343
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Sara-PA   FBpp0071564   146.3   1343   4.40     NP_524729   AAF46725
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, FYVE-type (IPR000306) Zinc finger, FYVE/PHD-type (IPR011011) Zinc finger, FYVE-type, SARA/endofin (IPR017165) Zinc finger, FYVE-related (IPR017455) Smad anchor for receptor activation, Smad-binding domain (IPR024608) Domain of unknown function DUF3480 (IPR022557) Zinc finger, RING/FYVE/PHD-type (IPR013083)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA438782   AA801714   AA978867   AE013599 AAF46725   AF239997 AAF64468   AI257946   AI260417   AI297664   AI533519   AJ310804 CAC37791   AW943160   AY051821 AAK93245   BI167220   BI170225   BI355218   BI484563   BI486992   BT058000   CK658927   CO268438   CO268444   CO297817   CO303232   CO308900   CO315888   CO320831   CO321143   CO326379   DN154103   EC066443   EC088533   EC208536   EC208538   EC221605   EC238267   EC246003   EC248995   EC250611   EC253079   EV593409   EV593928   EV594201   EV594813   EV597338   EV597606
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7K9H6 Q960V6
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
early endosome inferred from direct assay (Bokel et al., 2006, Bokel et al., 2006)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, larval salivary gland, larval trachea, adult female reproductive system, adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    101.85 Larval Midgut    173.7 Larval Hindgut    258.9 Larval Malpighian Tubules    232.6 Larval Fat Body    96.3 Larval Salivary Gland    121.3 Larval Trachea    103.65 Larval Carcass    148.9 Adult Head    111.8 Adult Eye    92.175 Adult Brain    189.5 Adult Thoracic-Abdominal Ganglion    214.4 Adult Crop    167.1 Adult Midgut    146.1 Adult Hindgut    207.4 Adult Malpighian Tubules    212.1 Adult Fat Body    93.6 Adult Salivary Gland    179.4 Adult Heart    75.725 Adult VirginFemale Spermatheca    82.2 Adult InseminatedFemale Spermatheca    100.7 Adult Ovary    147.2 Adult Testis    41.6 Adult Male Accessory Gland    70.6 Adult Carcass    129.5 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    101.85 Larval Midgut    173.7 Larval Hindgut    258.9 Larval Malpighian Tubules    232.6 Larval Fat Body    96.3 Larval Salivary Gland    121.3 Larval Trachea    103.65 Larval Carcass    148.9 Adult Head    111.8 Adult Eye    92.175 Adult Brain    189.5 Adult Thoracic-Abdominal Ganglion    214.4 Adult Crop    167.1 Adult Midgut    146.1 Adult Hindgut    207.4 Adult Malpighian Tubules    212.1 Adult Fat Body    93.6 Adult Salivary Gland    179.4 Adult Heart    75.725 Adult VirginFemale Spermatheca    82.2 Adult InseminatedFemale Spermatheca    100.7 Adult Ovary    147.2 Adult Testis    41.6 Adult Male Accessory Gland    70.6 Adult Carcass    129.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    101.85 Larval Midgut    173.7 Larval Hindgut    258.9 Larval Malpighian Tubules    232.6 Larval Fat Body    96.3 Larval Salivary Gland    121.3 Larval Trachea    103.65 Larval Carcass    148.9 Adult Head    111.8 Adult Eye    92.175 Adult Brain    189.5 Adult Thoracic-Abdominal Ganglion    214.4 Adult Crop    167.1 Adult Midgut    146.1 Adult Hindgut    207.4 Adult Malpighian Tubules    212.1 Adult Fat Body    93.6 Adult Salivary Gland    179.4 Adult Heart    75.725 Adult VirginFemale Spermatheca    82.2 Adult InseminatedFemale Spermatheca    100.7 Adult Ovary    147.2 Adult Testis    41.6 Adult Male Accessory Gland    70.6 Adult Carcass    129.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    101.85 Larval Midgut    173.7 Larval Hindgut    258.9 Larval Malpighian Tubules    232.6 Larval Fat Body    96.3 Larval Salivary Gland    121.3 Larval Trachea    103.65 Larval Carcass    148.9 Adult Head    111.8 Adult Eye    92.175 Adult Brain    189.5 Adult Thoracic-Abdominal Ganglion    214.4 Adult Crop    167.1 Adult Midgut    146.1 Adult Hindgut    207.4 Adult Malpighian Tubules    212.1 Adult Fat Body    93.6 Adult Salivary Gland    179.4 Adult Heart    75.725 Adult VirginFemale Spermatheca    82.2 Adult InseminatedFemale Spermatheca    100.7 Adult Ovary    147.2 Adult Testis    41.6 Adult Male Accessory Gland    70.6 Adult Carcass    129.5 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    101.85 Larval Midgut    173.7 Larval Hindgut    258.9 Larval Malpighian Tubules    232.6 Larval Fat Body    96.3 Larval Salivary Gland    121.3 Larval Trachea    103.65 Larval Carcass    148.9 Adult Head    111.8 Adult Eye    92.175 Adult Brain    189.5 Adult Thoracic-Abdominal Ganglion    214.4 Adult Crop    167.1 Adult Midgut    146.1 Adult Hindgut    207.4 Adult Malpighian Tubules    212.1 Adult Fat Body    93.6 Adult Salivary Gland    179.4 Adult Heart    75.725 Adult VirginFemale Spermatheca    82.2 Adult InseminatedFemale Spermatheca    100.7 Adult Ovary    147.2 Adult Testis    41.6 Adult Male Accessory Gland    70.6 Adult Carcass    129.5 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    101.85 Larval Midgut    173.7 Larval Hindgut    258.9 Larval Malpighian Tubules    232.6 Larval Fat Body    96.3 Larval Salivary Gland    121.3 Larval Trachea    103.65 Larval Carcass    148.9 Adult Head    111.8 Adult Eye    92.175 Adult Brain    189.5 Adult Thoracic-Abdominal Ganglion    214.4 Adult Crop    167.1 Adult Midgut    146.1 Adult Hindgut    207.4 Adult Malpighian Tubules    212.1 Adult Fat Body    93.6 Adult Salivary Gland    179.4 Adult Heart    75.725 Adult VirginFemale Spermatheca    82.2 Adult InseminatedFemale Spermatheca    100.7 Adult Ovary    147.2 Adult Testis    41.6 Adult Male Accessory Gland    70.6 Adult Carcass    129.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    101.85 Larval Midgut    173.7 Larval Hindgut    258.9 Larval Malpighian Tubules    232.6 Larval Fat Body    96.3 Larval Salivary Gland    121.3 Larval Trachea    103.65 Larval Carcass    148.9 Adult Head    111.8 Adult Eye    92.175 Adult Brain    189.5 Adult Thoracic-Abdominal Ganglion    214.4 Adult Crop    167.1 Adult Midgut    146.1 Adult Hindgut    207.4 Adult Malpighian Tubules    212.1 Adult Fat Body    93.6 Adult Salivary Gland    179.4 Adult Heart    75.725 Adult VirginFemale Spermatheca    82.2 Adult InseminatedFemale Spermatheca    100.7 Adult Ovary    147.2 Adult Testis    41.6 Adult Male Accessory Gland    70.6 Adult Carcass    129.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    101.85 Larval Midgut    173.7 Larval Hindgut    258.9 Larval Malpighian Tubules    232.6 Larval Fat Body    96.3 Larval Salivary Gland    121.3 Larval Trachea    103.65 Larval Carcass    148.9 Adult Head    111.8 Adult Eye    92.175 Adult Brain    189.5 Adult Thoracic-Abdominal Ganglion    214.4 Adult Crop    167.1 Adult Midgut    146.1 Adult Hindgut    207.4 Adult Malpighian Tubules    212.1 Adult Fat Body    93.6 Adult Salivary Gland    179.4 Adult Heart    75.725 Adult VirginFemale Spermatheca    82.2 Adult InseminatedFemale Spermatheca    100.7 Adult Ovary    147.2 Adult Testis    41.6 Adult Male Accessory Gland    70.6 Adult Carcass    129.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    111.8   NA  Eye    92.175   NA  Brain    189.5   101.85  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    214.4   NA  Crop    167.1   173.7  Midgut    146.1   258.9  Hindgut    207.4   232.6  Malpighian Tubules    212.1   96.3  Fat Body    93.6   121.3  Salivary Gland    no informative data   NA  Heart    75.725   103.65  Trachea    NA   NA  VirginFemale Spermatheca    82.2   NA  InseminatedFemale Spermatheca    100.7   NA  Ovary    147.2   NA  Testis    41.6   NA  Male Accessory Gland    70.6   no informative data  Carcass    129.5 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    7 central nervous system, pupae P8    8 head, virgin 1-day female    6 head, virgin 4-day female    7 head, virgin 20-day female    9 head, mated 1-day female    6 head, mated 4-day female    6 head, mated 20-day female    6 head, mated 1-day male    10 head, mated 4-day male    10 head, mated 20-day male    12 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    7 digestive system, 4-day adult    7 digestive system, 20-day adult    8 fat body, larvae L3 wandering    4 fat body, white prepupae    8 fat body, pupae P8    4 carcass, larvae L3 wandering    12 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    6 ovary, virgin 4-day female    19 ovary, mated 4-day female    14 testis, mated 4-day male    4 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    7 central nervous system, pupae P8    8 head, virgin 1-day female    6 head, virgin 4-day female    7 head, virgin 20-day female    9 head, mated 1-day female    6 head, mated 4-day female    6 head, mated 20-day female    6 head, mated 1-day male    10 head, mated 4-day male    10 head, mated 20-day male    12 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    7 digestive system, 4-day adult    7 digestive system, 20-day adult    8 fat body, larvae L3 wandering    4 fat body, white prepupae    8 fat body, pupae P8    4 carcass, larvae L3 wandering    12 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    6 ovary, virgin 4-day female    19 ovary, mated 4-day female    14 testis, mated 4-day male    4 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    7 central nervous system, pupae P8    8 head, virgin 1-day female    6 head, virgin 4-day female    7 head, virgin 20-day female    9 head, mated 1-day female    6 head, mated 4-day female    6 head, mated 20-day female    6 head, mated 1-day male    10 head, mated 4-day male    10 head, mated 20-day male    12 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    7 digestive system, 4-day adult    7 digestive system, 20-day adult    8 fat body, larvae L3 wandering    4 fat body, white prepupae    8 fat body, pupae P8    4 carcass, larvae L3 wandering    12 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    6 ovary, virgin 4-day female    19 ovary, mated 4-day female    14 testis, mated 4-day male    4 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    7 central nervous system, pupae P8    8 head, virgin 1-day female    6 head, virgin 4-day female    7 head, virgin 20-day female    9 head, mated 1-day female    6 head, mated 4-day female    6 head, mated 20-day female    6 head, mated 1-day male    10 head, mated 4-day male    10 head, mated 20-day male    12 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    7 digestive system, 4-day adult    7 digestive system, 20-day adult    8 fat body, larvae L3 wandering    4 fat body, white prepupae    8 fat body, pupae P8    4 carcass, larvae L3 wandering    12 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    6 ovary, virgin 4-day female    19 ovary, mated 4-day female    14 testis, mated 4-day male    4 accessory gland, mated 4-day male    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    7 central nervous system, pupae P8    8 head, virgin 1-day female    6 head, virgin 4-day female    7 head, virgin 20-day female    9 head, mated 1-day female    6 head, mated 4-day female    6 head, mated 20-day female    6 head, mated 1-day male    10 head, mated 4-day male    10 head, mated 20-day male    12 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    7 digestive system, 4-day adult    7 digestive system, 20-day adult    8 fat body, larvae L3 wandering    4 fat body, white prepupae    8 fat body, pupae P8    4 carcass, larvae L3 wandering    12 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    6 ovary, virgin 4-day female    19 ovary, mated 4-day female    14 testis, mated 4-day male    4 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    7 central nervous system, pupae P8    8 head, virgin 1-day female    6 head, virgin 4-day female    7 head, virgin 20-day female    9 head, mated 1-day female    6 head, mated 4-day female    6 head, mated 20-day female    6 head, mated 1-day male    10 head, mated 4-day male    10 head, mated 20-day male    12 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    7 digestive system, 4-day adult    7 digestive system, 20-day adult    8 fat body, larvae L3 wandering    4 fat body, white prepupae    8 fat body, pupae P8    4 carcass, larvae L3 wandering    12 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    6 ovary, virgin 4-day female    19 ovary, mated 4-day female    14 testis, mated 4-day male    4 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    7 central nervous system, pupae P8    8 head, virgin 1-day female    6 head, virgin 4-day female    7 head, virgin 20-day female    9 head, mated 1-day female    6 head, mated 4-day female    6 head, mated 20-day female    6 head, mated 1-day male    10 head, mated 4-day male    10 head, mated 20-day male    12 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    7 digestive system, 4-day adult    7 digestive system, 20-day adult    8 fat body, larvae L3 wandering    4 fat body, white prepupae    8 fat body, pupae P8    4 carcass, larvae L3 wandering    12 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    6 ovary, virgin 4-day female    19 ovary, mated 4-day female    14 testis, mated 4-day male    4 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    7 central nervous system, pupae P8    8 head, virgin 1-day female    6 head, virgin 4-day female    7 head, virgin 20-day female    9 head, mated 1-day female    6 head, mated 4-day female    6 head, mated 20-day female    6 head, mated 1-day male    10 head, mated 4-day male    10 head, mated 20-day male    12 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    7 digestive system, 4-day adult    7 digestive system, 20-day adult    8 fat body, larvae L3 wandering    4 fat body, white prepupae    8 fat body, pupae P8    4 carcass, larvae L3 wandering    12 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    6 ovary, virgin 4-day female    19 ovary, mated 4-day female    14 testis, mated 4-day male    4 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    31 embryo 02-04hr    10 embryo 04-06hr    13 embryo 06-08hr    16 embryo 08-10hr    15 embryo 10-12hr    14 embryo 12-14hr    15 embryo 14-16hr    13 embryo 16-18hr    15 embryo 18-20hr    15 embryo 20-22hr    12 embryo 22-24hr    14 larva L1    10 larva L2    9 larva L3 12hr old    9 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    21 larva L3 puffstage 7-9    31 white prepupae new    65 white prepupae 12hr    51 white prepupae 24hr    32 pupae 2d postWPP    25 pupae 3d postWPP    15 pupae 4d postWPP    14 adult male 01day    14 adult male 05day    15 adult male 30day    15 adult female 01day    17 adult female 05day    25 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (31) embryo 02-04hr    10 embryo 04-06hr    13 embryo 06-08hr    16 embryo 08-10hr    15 embryo 10-12hr    14 embryo 12-14hr    15 embryo 14-16hr    13 embryo 16-18hr    15 embryo 18-20hr    15 embryo 20-22hr    12 embryo 22-24hr    14 larva L1    10 larva L2    9 larva L3 12hr old    9 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    21 larva L3 puffstage 7-9  (31) white prepupae new  (65) white prepupae 12hr  (51) white prepupae 24hr  (32) pupae 2d postWPP    25 pupae 3d postWPP    15 pupae 4d postWPP    14 adult male 01day    14 adult male 05day    15 adult male 30day    15 adult female 01day    17 adult female 05day    25 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    31 embryo 02-04hr    10 embryo 04-06hr    13 embryo 06-08hr    16 embryo 08-10hr    15 embryo 10-12hr    14 embryo 12-14hr    15 embryo 14-16hr    13 embryo 16-18hr    15 embryo 18-20hr    15 embryo 20-22hr    12 embryo 22-24hr    14 larva L1    10 larva L2    9 larva L3 12hr old    9 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    21 larva L3 puffstage 7-9    31 white prepupae new    65 white prepupae 12hr    51 white prepupae 24hr    32 pupae 2d postWPP    25 pupae 3d postWPP    15 pupae 4d postWPP    14 adult male 01day    14 adult male 05day    15 adult male 30day    15 adult female 01day    17 adult female 05day    25 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    31 embryo 02-04hr    10 embryo 04-06hr    13 embryo 06-08hr    16 embryo 08-10hr    15 embryo 10-12hr    14 embryo 12-14hr    15 embryo 14-16hr    13 embryo 16-18hr    15 embryo 18-20hr    15 embryo 20-22hr    12 embryo 22-24hr    14 larva L1    10 larva L2    9 larva L3 12hr old    9 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    21 larva L3 puffstage 7-9    31 white prepupae new    65 white prepupae 12hr    51 white prepupae 24hr    32 pupae 2d postWPP    25 pupae 3d postWPP    15 pupae 4d postWPP    14 adult male 01day    14 adult male 05day    15 adult male 30day    15 adult female 01day    17 adult female 05day    25 adult female 30day    25 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    31 embryo 02-04hr    10 embryo 04-06hr    13 embryo 06-08hr    16 embryo 08-10hr    15 embryo 10-12hr    14 embryo 12-14hr    15 embryo 14-16hr    13 embryo 16-18hr    15 embryo 18-20hr    15 embryo 20-22hr    12 embryo 22-24hr    14 larva L1    10 larva L2    9 larva L3 12hr old    9 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    21 larva L3 puffstage 7-9    31 white prepupae new    65 white prepupae 12hr    51 white prepupae 24hr    32 pupae 2d postWPP    25 pupae 3d postWPP    15 pupae 4d postWPP    14 adult male 01day    14 adult male 05day    15 adult male 30day    15 adult female 01day    17 adult female 05day    25 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  31 embryo 02-04hr    10 embryo 04-06hr    13 embryo 06-08hr    16 embryo 08-10hr    15 embryo 10-12hr    14 embryo 12-14hr    15 embryo 14-16hr    13 embryo 16-18hr    15 embryo 18-20hr    15 embryo 20-22hr    12 embryo 22-24hr    14 larva L1    10 larva L2    9 larva L3 12hr old    9 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    21 larva L3 puffstage 7-9  31 white prepupae new  (65) white prepupae 12hr  (51) white prepupae 24hr  32 pupae 2d postWPP    25 pupae 3d postWPP    15 pupae 4d postWPP    14 adult male 01day    14 adult male 05day    15 adult male 30day    15 adult female 01day    17 adult female 05day    25 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    31 embryo 02-04hr    10 embryo 04-06hr    13 embryo 06-08hr    16 embryo 08-10hr    15 embryo 10-12hr    14 embryo 12-14hr    15 embryo 14-16hr    13 embryo 16-18hr    15 embryo 18-20hr    15 embryo 20-22hr    12 embryo 22-24hr    14 larva L1    10 larva L2    9 larva L3 12hr old    9 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    21 larva L3 puffstage 7-9    31 white prepupae new    65 white prepupae 12hr    51 white prepupae 24hr    32 pupae 2d postWPP    25 pupae 3d postWPP    15 pupae 4d postWPP    14 adult male 01day    14 adult male 05day    15 adult male 30day    15 adult female 01day    17 adult female 05day    25 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    31 embryo 02-04hr    10 embryo 04-06hr    13 embryo 06-08hr    16 embryo 08-10hr    15 embryo 10-12hr    14 embryo 12-14hr    15 embryo 14-16hr    13 embryo 16-18hr    15 embryo 18-20hr    15 embryo 20-22hr    12 embryo 22-24hr    14 larva L1    10 larva L2    9 larva L3 12hr old    9 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    21 larva L3 puffstage 7-9    31 white prepupae new    65 white prepupae 12hr    51 white prepupae 24hr    32 pupae 2d postWPP    25 pupae 3d postWPP    15 pupae 4d postWPP    14 adult male 01day    14 adult male 05day    15 adult male 30day    15 adult female 01day    17 adult female 05day    25 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    26 Schneider line 2 Sg4    11 embryonic 1182-4H    13 embryonic GM2    15 embryonic Kc167    13 embryonic S1    24 embryonic S3    12 leg disc CME L1    11 wing disc CME-W2    11 wing disc ML-DmD8    9 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    11 wing disc ML-DmD21    4 wing disc ML-DmD32    9 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2    12 tumorous blood cells mbn2    18 ovary fGS/OSS    10 ovary OSC    7 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  26 Schneider line 2 Sg4    11 embryonic 1182-4H    13 embryonic GM2    15 embryonic Kc167    13 embryonic S1    24 embryonic S3    12 leg disc CME L1    11 wing disc CME-W2    11 wing disc ML-DmD8    9 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    11 wing disc ML-DmD21    4 wing disc ML-DmD32    9 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2    12 tumorous blood cells mbn2    18 ovary fGS/OSS    10 ovary OSC    7 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    26 Schneider line 2 Sg4    11 embryonic 1182-4H    13 embryonic GM2    15 embryonic Kc167    13 embryonic S1    24 embryonic S3    12 leg disc CME L1    11 wing disc CME-W2    11 wing disc ML-DmD8    9 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    11 wing disc ML-DmD21    4 wing disc ML-DmD32    9 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2    12 tumorous blood cells mbn2    18 ovary fGS/OSS    10 ovary OSC    7 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    26 Schneider line 2 Sg4    11 embryonic 1182-4H    13 embryonic GM2    15 embryonic Kc167    13 embryonic S1    24 embryonic S3    12 leg disc CME L1    11 wing disc CME-W2    11 wing disc ML-DmD8    9 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    11 wing disc ML-DmD21    4 wing disc ML-DmD32    9 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2    12 tumorous blood cells mbn2    18 ovary fGS/OSS    10 ovary OSC    7 ovary OSS    6 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    26 Schneider line 2 Sg4    11 embryonic 1182-4H    13 embryonic GM2    15 embryonic Kc167    13 embryonic S1    24 embryonic S3    12 leg disc CME L1    11 wing disc CME-W2    11 wing disc ML-DmD8    9 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    11 wing disc ML-DmD21    4 wing disc ML-DmD32    9 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2    12 tumorous blood cells mbn2    18 ovary fGS/OSS    10 ovary OSC    7 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  26 Schneider line 2 Sg4    11 embryonic 1182-4H    13 embryonic GM2    15 embryonic Kc167    13 embryonic S1    24 embryonic S3    12 leg disc CME L1    11 wing disc CME-W2    11 wing disc ML-DmD8    9 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    11 wing disc ML-DmD21    4 wing disc ML-DmD32    9 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2    12 tumorous blood cells mbn2    18 ovary fGS/OSS    10 ovary OSC    7 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    26 Schneider line 2 Sg4    11 embryonic 1182-4H    13 embryonic GM2    15 embryonic Kc167    13 embryonic S1    24 embryonic S3    12 leg disc CME L1    11 wing disc CME-W2    11 wing disc ML-DmD8    9 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    11 wing disc ML-DmD21    4 wing disc ML-DmD32    9 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2    12 tumorous blood cells mbn2    18 ovary fGS/OSS    10 ovary OSC    7 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    26 Schneider line 2 Sg4    11 embryonic 1182-4H    13 embryonic GM2    15 embryonic Kc167    13 embryonic S1    24 embryonic S3    12 leg disc CME L1    11 wing disc CME-W2    11 wing disc ML-DmD8    9 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    11 wing disc ML-DmD21    4 wing disc ML-DmD32    9 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2    12 tumorous blood cells mbn2    18 ovary fGS/OSS    10 ovary OSC    7 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    5 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    7 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    15 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    8 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    10 Paraquat 10 mM 48 hrs, 4-day adult    14 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    5 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    7 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    15 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    8 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    10 Paraquat 10 mM 48 hrs, 4-day adult    14 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    5 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    7 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    15 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    8 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    10 Paraquat 10 mM 48 hrs, 4-day adult    14 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    5 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    7 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    15 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    8 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    10 Paraquat 10 mM 48 hrs, 4-day adult    14 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    5 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    7 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    15 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    8 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    10 Paraquat 10 mM 48 hrs, 4-day adult    14 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    5 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    7 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    15 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    8 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    10 Paraquat 10 mM 48 hrs, 4-day adult    14 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    5 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    7 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    15 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    8 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    10 Paraquat 10 mM 48 hrs, 4-day adult    14 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    5 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    7 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    15 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    8 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    10 Paraquat 10 mM 48 hrs, 4-day adult    14 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_23 mE1_20_mRNA_expression_cluster_09
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0026369 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG15667-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4da.G32 SaraEY07208 lethal | embryonic stage | maternal effect | recessive Sara1 Sara12 lethal | embryonic stage | recessive | rescuable maternal effect Sara12 lethal | larval stage | recessive Sara12 lethal | pupal stage | recessive Sara12 viable, with Scer\GAL4pnr-MD237 SaraGD8765 Other Phenotypes Allele increased cell death Sara1 increased cell death (with Df(2R)PK1) Sara12 neuroanatomy defective | larval stage, with Sdc48/Sdc10608 SaraUbi.PJ visible Sara1 Phenotype manifest in Allele double row | ectopic, with Scer\GAL4vg.int2.1 SaraF678A.Scer\UAS.T:Hsap\MYC,T:Zzzz\His6 NMJ bouton | larval stage, with Sdc48/Sdc10608 SaraUbi.PJ posterior crossvein Sara12 Sara1 triple row, with Scer\GAL4vg.int2.1 SaraF678A.Scer\UAS.T:Hsap\MYC,T:Zzzz\His6 wing disc Sara1 wing disc (with Df(2R)PK1) Sara12 wing margin | anterior compartment, with Scer\GAL4vg.int2.1 SaraF678A.Scer\UAS.T:Hsap\MYC,T:Zzzz\His6 wing margin | posterior compartment, with Scer\GAL4vg.int2.1 SaraF678A.Scer\UAS.T:Hsap\MYC,T:Zzzz\His6 SaraScer\UAS.T:Hsap\MYC,T:Zzzz\His6 wing vein Sara12 Sara1 wing vein | ectopic Sara12 wing vein L5, with Scer\GAL4vg.int2.1 SaraF678A.Scer\UAS.T:Hsap\MYC,T:Zzzz\His6
Classical Alleles ( 5 )
For All Classical Alleles Show
Allele of Sara Class Mutagen Stocks Known lesion SaraEY07208 1 Yes Sara12 loss of function allele P-element activity 0 Yes Sara1 loss of function allele ethyl methanesulfonate 0 Yes Sara250 0 -- Saraunspecified 0 --
Alleles Carried on Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Sara Class Mutagen Stocks Known lesion SaraF678A.Scer\UAS.T:Hsap\MYC,T:Zzzz\His6 in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - site directed mutagenesis 1 Yes SaraGD8765 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes SaraHMS01239 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes SaraScer\UAS.T:Hsap\MYC,T:Zzzz\His6 in vitro construct - regulatory fusion in vitro construct - coding region fusion 1 Yes SaraUbi.PJ in vitro construct - regulatory fusion 1 Yes SaraScer\UAS.T:Avic\GFP in vitro construct - coding region fusion in vitro construct - regulatory fusion 0 Yes SaraTub.PB in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Partially disrupted in	Df(2R)Sara12 (Bokel et al., 2006)
Disrupted in	Df(2R)48 (Johnson et al., 2004) Df(2R)Exel6076 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD8765} NA P{TRiP.HMS01239} NA P{UAS-Sara.F678A.MYC.His6} NA P{UAS-Sara.GFP} NA P{UAS-Sara.MYC.His6} NA characterization construct P{Tub-Sara.B} NA P{Ubi-Sara.J} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}SdcEY07208 NA P{GSV1}C596C596 NA P{Mae-UAS.6.11}B2034B2034 NA
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function
CV term Evidence References
protein phosphatase 1 binding inferred from physical interaction with flw (Bennett et al., 2006) inferred from physical interaction with Pp1-13C (Bennett et al., 2006) inferred from physical interaction with Pp1-87B (Bennett et al., 2006) inferred from physical interaction with Pp1α-96A (Bennett et al., 2006)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
early endosome inferred from direct assay (Bokel et al., 2006, Bokel et al., 2006)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
metal ion binding inferred from electronic annotation with InterPro:IPR000306 (FlyBase Curators et al., 2004-) transforming growth factor beta receptor binding non-traceable author statement (Bennett and Alphey, 2002)
Biological Process
CV term Evidence References
protein localization non-traceable author statement (Bennett and Alphey, 2002) transforming growth factor beta receptor signaling pathway non-traceable author statement (Bennett, 2001.3.30)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Sara - Smox anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Sara - mib2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Sara allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 68929 DroID - A comprehensive database of gene and protein interactions. • FBgn0026369 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 44263 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q960V6
Orthologs
OrthoDB Orthologs (50) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6DZ2DK Dipteran inclusive ortholog search EOG65496Q Insect inclusive ortholog search EOG6FJ74N Arthropod inclusive ortholog search EOG6H9W1D Metazoa inclusive ortholog search EOG66XB26
Orthologs in Drosophila Species (EOG6DZ2DK)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Sara     Drosophila simulans   Dsim\GD11597 Y   Drosophila sechellia   Dsec\GM15837 Y   Drosophila erecta   Dere\GG22114 Y   Drosophila yakuba   Dyak\GE12197 Y   Drosophila ananassae   Dana\GF12817 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA13882 Y   Drosophila persimilis   Dper\GL16978 Y   Drosophila willistoni   Dwil\GK20901 Y   Drosophila virilis   Dvir\GJ20050 Y   Drosophila mojavensis   Dmoj\GI19076 Y   Drosophila grimshawi   Dgri\GH21833 Y
Orthologs in non-Drosophila Dipterans (EOG65496Q)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL009110   Anopheles gambiae Malaria mosquito  Agam\AGAP004049   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ004061
Orthologs in non-Dipteran Insects (EOG6FJ74N)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB45214   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG001422   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH21329   Atta cephalotes Leafcutter ant  Acep\ACEP11540   Atta cephalotes Leafcutter ant  Acep\ACEP11552   Atta cephalotes Leafcutter ant  Acep\ACEP11544   Camponotus floridanus Florida carpenter ant  Cflo\CFLO22399   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL17343   Linepithema humile Argentine ant  Lhum\LH16784   Pogonomyrmex barbatus Red harvester ant  Pbar\PB17677   Solenopsis invicta Red fire ant  Sinv\SINV16426   Solenopsis invicta Red fire ant  Sinv\SINV16394   Solenopsis invicta Red fire ant  Sinv\SINV16413   Acyrthosiphon pisum Pea aphid  Apim\ACYPI003303   Pediculus humanus Human body louse  Phum\PHUM397040   Tribolium castaneum Red flour beetle  Tcas\GLEAN_15198
Orthologs in non-Insect Arthropods (EOG6H9W1D)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_219380   Ixodes scapularis Deer tick  Isca\ISCW015633
Orthologs in non-Arthropod Metazoa (EOG66XB26)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\aka-1   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_014763gn   Danio rerio Zebrafish  Drer\ENSDARG00000075747   Danio rerio Zebrafish  Drer\ENSDARG00000023701   Danio rerio Zebrafish  Drer\ENSDARG00000087295   Danio rerio Zebrafish  Drer\ENSDARG00000062723   Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000031551   Xenopus tropicalis Western clawed frog  Xtro\zfyve9   Gallus gallus Domestic chicken  Ggal\LOC427315   Gallus gallus Domestic chicken  Ggal\LOC768383   Gallus gallus Domestic chicken  Ggal\ZFYVE9   Mus musculus House mouse  Mmus\Zfyve16   Mus musculus House mouse  Mmus\Zfyve9   Rattus norvegicus Norway rat  Rnor\Zfyve9   Rattus norvegicus Norway rat  Rnor\Zfyve16   Homo sapiens Human  Hsap\ZFYVE16   Homo sapiens Human  Hsap\ENSG00000157077
Human Orthologs (2)
Gene OMIM HGNC Hsap\ZFYVE16     Hsap\ENSG00000157077
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD11597 Drosophila sechellia Dsec\GM15837 Drosophila erecta Dere\GG22114 Drosophila yakuba Dyak\GE12197 Drosophila ananassae Dana\GF12817 Drosophila pseudoobscura pseudoobscura Dpse\GA13882 Drosophila persimilis Dper\GL16978 Drosophila willistoni Dwil\GK20901 Drosophila virilis Dvir\GJ20050 Drosophila mojavensis Dmoj\GI19076 Drosophila grimshawi Dgri\GH21833
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	23709 w*; P{UAS-Sara.MYC.His6}BC 23710 w*; P{UAS-Sara.F678A.MYC.His6}B26 8585 w*; Df(2R)48, P{Ubi-Sara.J}2/CyO, P{ActGFP}JMR1 34894 y1 sc* v1; P{TRiP.HMS01239}attP2 16802 y1 w67c23; P{EPgy2}SdcEY07208 SaraEY07208
VDRC	v19150 w1118; P{GD8765}v19150/CyO
Genomic Clones ( 1 )
	BACR13H23 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 40 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD33044
Other clones	FI05490
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GM03381 GM29960 LD13137 LP04269 LP06454 LP12019 LP16254 RE07556 RE11616 RE67682 RE70484 SD05374
Other clones	19329 56811 120660 121693 156492 160145 183257 214223.46 CK01.119D.A2 CK01.119D.D2 Dmel_neb_000639_0688_3727 Dmel_neb_006531_0605_3710 Dmel_neb_007098_0851_0702 Dmel_neb_009886_0691_1223 Dmel_neb_010687_0698_2678 Dmel_neb_012813_0819_2913 EK091333 EK091345 EK170615 EK179802 EK240632 EK259621 EK262934 EK288359 EK290404 EP03813
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0026369 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 44263
Antibody Information
	polyclonal (Coumailleau et al., 2009)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Sara CG15667 (FlyBase, 1996-)
Additional comments	Source for merge of Sara CG15667 was sequence comparison (date:000423). (FlyBase, 1996-)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079990 RefSeq (Proteins) • NP_524729 DDBJ / EMBL / GenBank • AA438782 AA978867 AAF46725 AAF64468 AAK93245 AAM70899 AF239997 AJ310804 AW943160 AY051821 CAC37791 Entrez Gene - A searchable database of RefSeq genes. • 44263 UniProtKB/TrEMBL • Q7K9H6 Q960V6
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, FYVE-type (IPR000306) Zinc finger, FYVE/PHD-type (IPR011011) Zinc finger, FYVE-type, SARA/endofin (IPR017165) Zinc finger, FYVE-related (IPR017455) Smad anchor for receptor activation, Smad-binding domain (IPR024608) Domain of unknown function DUF3480 (IPR022557) Zinc finger, RING/FYVE/PHD-type (IPR013083)
Linkouts
	BioGRID - A database of protein and genetic interactions • 68929 DroID - A comprehensive database of gene and protein interactions. • FBgn0026369 DRSC - Results from RNAi screens. • FBgn0026369 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0026369 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG15667-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0026369 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 44263 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 44263 modMine - Data generated by the modENCODE project. • FBgn0026369 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q960V6
Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym	CG15667 (Brody et al., 2002, Molnar et al., 2006, Grieder et al., 2007, Ni et al., 2011.7.19, Bennett et al., 2006) dSARA (Chong et al., 2004, Bokel and Gonzalez-Gaitan, 2003, Martin et al., 2002, Bennett and Alphey, 2002, Bennett and Alphey, 2001, Das et al., 2000, Martin et al., 1999, Peterson et al., 2012) SARA (Ashe, 2006, Gonzalez-Gaitan, 2003, Ashe, 2002, Marques, 2005, Muñoz-Descalzo et al., 2010, Peterson et al., 2012) sara (Lee et al., 2003, Epstein et al., 2002, Epstein et al., 2001, Bokel et al., 2006, Molnar et al., 2006, Johnson et al., 2006, Schulz et al., 2011) Sara (Jordan et al., 2005, Gonzales-Gaitan, 2007, Knoblich, 2006, Bokel et al., 2006, Kirchner, 2007.7.19, Grieder et al., 2007, Coumailleau et al., 2009, Halbsgut et al., 2011, Zeng et al., 2008, Winkler et al., 2005, Bennett et al., 2006, Daskalaki et al., 2011, Couturier et al., 2012)
Name Synonym	Smad anchor for receptor activation (Bennett and Alphey, 2001, Epstein et al., 2001, Jordan et al., 2005, Bennett et al., 2006) Smad Anchor for Receptor Activation (Peterson et al., 2012)
Secondary FlyBase IDs
	FBgn0034630
References ( 61 )
Generate a list of	All references relating to this gene ( 61 )
List References by type	Research paper  ( 22 ) Supplementary material  ( 7 ) Review  ( 7 ) Personal communication to FlyBase  ( 9 ) Abstract  ( 9 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 2 ) Thesis  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 5 )
	Couturier et al., 2012, Nat. Cell Biol. 14(2): 131--139 Endocytosis by Numb breaks Notch symmetry at cytokinesis. [FBrf0217937] Peterson et al., 2012, PLoS ONE 7(5): e36548 R-smad competition controls activin receptor output in Drosophila. [FBrf0218205] Daskalaki et al., 2011, J. Cell Biol. 195(6): 1017--1031 Distinct intracellular motifs of Delta mediate its ubiquitylation and activation by Mindbomb1 and Neuralized. [FBrf0216896] Halbsgut et al., 2011, Mol. Biol. Cell 22(22): 4373--4379 Apical-basal polarity in Drosophila neuroblasts is independent of vesicular trafficking. [FBrf0216808] Schulz et al., 2011, EMBO Rep. 12(10): 1039--1046 Drosophila syndecan regulates tracheal cell migration by stabilizing Robo levels. [FBrf0216287] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...