Gene Dmel\SRPK

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General Information

Symbol

Dmel\SRPK

Species

D. melanogaster

Name

SRPK

Annotation symbol

CG8174

Feature type

protein_coding_gene

FlyBase ID

FBgn0026370

Created / Updated

2003-12-02/2003-12-02

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

51F11-51F12

Sequence location

2R:11,268,223..11,275,362 [+]

Map ( GBrowse )

Summary Information

Automatically generated summary

See sections below for more information

This gene is referred to in FlyBase by the symbol SRPK (CG8174, FBgn0026370). It has the cytological map location 51F11-51F12. Its sequence location is 2R:11268223..11275362. Its molecular function is described as: protein kinase activity; protein serine/threonine kinase activity; ATP binding. It is involved in the biological process protein amino acid phosphorylation. 2 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

51F11-51F12

Limits computationally determined from genome sequence between P{lacW}dup^k03308 and P{lacW}Vha36^k07207

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

52A1-52A2

(Allemand, 2000.8.29)

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Molecular Map Data

Gene Order (in direction of increasing cytology)

References

Gene Order (overall orientation not stated)

References

Gene Model & Products

Please see the GBrowse view of Dmel\SRPK for information on other features

Comments on Gene Model

DGC clone SD03158 appears problematic: incomplete CDS

DGC clone SD09672 appears problematic: incomplete CDS (at the 3' end).

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

SRPK-RA

FBtr0087383

NM_166093

5137

764

SRPK-RB

FBtr0087384

NM_137190

4977

764

SRPK-RC

FBtr0087385

NM_166094

4483

607

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kD)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

SRPK-PA

FBpp0086515

85.1

764

9.44

NP_725458

AAF58140

SRPK-PB

FBpp0086516

85.1

764

9.44

NP_611034

AAM68537

SRPK-PC

FBpp0086517

68.1

607

8.99

NP_725459

AAM68538

Additional Polypeptide Data & Comments

Reported size (kD)

Comments

External Data

Linkouts

PANTHER - Protein classification by function, families, and pathways

•

FBgn0026370

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Protein kinase, core (IPR000719)

Serine/threonine protein kinase, active site (IPR008271)

Protein kinase-like (IPR011009)

Serine/threonine protein kinase-related (IPR017442)

Protein kinase ATP binding, conserved site (IPR017441)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

Maps to

DS03596

(Mattox, 1999.3.3)

Does NOT map to

Identified with

(BDGP Project Members, 2000-)

Mapped Features & Mutations

Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

DEDB - Drosophila exon database: splicing graphs

•

12421

Crossreferences

Expression Data

FlyBase-Curated Data

Transcript and
Protein data

Please see the FlyBase Gene Expression Report for details of gene expression from the literature.

Summary of Transcript Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

Summary of Polypeptide Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

Microarray Data

Developmental timecourse, Costello et al., 2008 (Original data from Arbeitman et al., 2002)

Untitled Document detailed view

AI531875
AI456074
AI543080

External Data & Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0026370

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

FBgn0026370

GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies

•

FBgn0026370

BDGP expression data

•

Show all BDGP original images, annotations and embryonic microarray data for SRPK

FlyExpress - Embryonic expression images (BDGP data)

•

Show all FlyExpress processed images for SRPK

Alleles & Phenotypes

Summary of Allele Phenotypes

Phenotype manifest in

Allele

Classical Alleles ( 1 )

For All Classical Alleles Show

Allele of SRPK	Class	Mutagen	Stocks	Known lesion
SRPK^EY03876		P-element activity	1	--

Alleles Carried on Transgenic Constructs ( 1 )

For All Alleles Carried on Transgenic Constructs Show

Allele of SRPK	Class	Mutagen	Stocks	Known lesion
SRPK^GD13826		in vitro construct \| RNAi in vitro construct \| regulatory fusion	1	Yes

Aneuploid Aberrations

Useful deficiency

Df(2R)L4

Useful duplication

Dp(2;2)SMG45

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

UAS construct

P{GD13826}

Insertions

Type of insertions

Name

Expression data

miscellaneous insertions

PBac{WH}SRPK^f06594

insertion of mobile activating element

P{EPgy2}SRPK^EY03876

P{Mae-UAS.6.11}B0323^B0323

Related Comments

Please look at the allele reports for the complete phenotype data

Gene Ontology: Function, Process & Cellular Component ( 4 )

Molecular Function

CV term

Evidence

References

ATP binding

inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR017441, InterPro:IPR017442

(FlyBase Curators et al., 2004-)

protein kinase activity

traceable author statement

(Mattox et al., 1999)

inferred from sequence or structural similarity with NCBI_NP:003128

(Mount and Salz, 2000)

non-traceable author statement

(Allemand, 2000.8.29)

protein serine/threonine kinase activity

inferred from sequence or structural similarity with UniProtKB:Q9UPE1

(FlyBase, 1992-)

Biological Process

CV term

Evidence

References

protein amino acid phosphorylation

traceable author statement

(Mattox et al., 1999)

inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR008271, InterPro:IPR017441, InterPro:IPR017442

(FlyBase Curators et al., 2004-)

Cellular Component

CV term

Evidence

References

Sequence Ontology: Class of Gene

protein_coding_gene

nuclear_gene

Interactions & Pathways

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

SRPK allele

Gene

References

External Data

Linkouts

BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions

•

62442

Orthologs

Genome-wide drosophilid orthologs

Dana\GF13033

Dere\GG20515

Dgri\GH20233

Dmoj\GI19404

Dper\GL20063

Dpse\GA20867

Dsec\GM21607

Dsim\GD11112

Dvir\GJ22465

Dwil\GK23016

Dyak\GE11700

Curated drosophilid orthologs

Dpse\GA20867

Linkouts

InParanoid orthologs - Eukaryotic orthologs

•

ENSBTAP00000022397
Bos taurus (Ensembl)
ENSCAFP00000006034
Canis familiaris (Ensembl)
ENSCINP00000013872
Ciona intestinalis (Ensembl)
NEWSINFRUP00000150696
Takifugu rubripes (Ensembl)
NEWSINFRUP00000168495
Takifugu rubripes (Ensembl)
ENSGALP00000001306
Gallus gallus (Ensembl)
ENSP00000339450
Homo sapiens (Ensembl)
ENSMMUP00000029939
Macaca mulatta (Ensembl)
ENSMODP00000017177
Monodelphis domestica (Ensembl)
ENSPTRP00000045275
Pan troglodytes (Ensembl)
ENSRNOP00000000612
Rattus norvegicus (Ensembl)
GSTENP00013029001
Tetraodon nigroviridis (Ensembl)
ENSXETP00000001645
Xenopus tropicalis (Ensembl)
Q69ML8
Oryza sativa (Gramene)
Q8W306
Oryza sativa (Gramene)
AT3G44850.1
Arabidopsis thaliana (Arabidopsis)
AT3G53030.1
Arabidopsis thaliana (Arabidopsis)
WBGene00031566
Caenorhabditis briggsae (Wormbase)
ZDB-CDNA-040425-1197
Danio rerio (Zfin)
ZDB-GENE-030131-2399
Danio rerio (Zfin)
DDB0230135
Dictyostelium discoideum (Dictybase)
MGI:106908
Mus musculus (Informatics)
YMR216C
Saccharomyces cerevisiae (Yeastgenome)

Functional Complementation between Species

Inter-Species Misexpression Data

Produces phenotype in

Produces NO phenotype in

Stocks & Reagents

Stocks Listed in FlyBase ( 2 )

VDRC

v26933

w¹¹¹⁸; P{GD13826}v26933/TM3

Bloomington

15685

y¹ w^67c23; P{EPgy2}SRPK^EY03876

Genomic Clones ( 1 )

BACR03D24

cDNA Clones ( 48 )

Please Note

This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA Clones, Fully Sequenced

BDGP DGC clones

Other clones

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones