FlyBase Gene Report: Dmel\RpL23A

General Information

Symbol

Dmel\RpL23A

Species

D. melanogaster

Name

Ribosomal protein L23A

Annotation Symbol

CG7977

Feature Type

protein_coding_gene

FlyBase ID

FBgn0026372

Gene Model Status

Current

Stock Availability

5 publicly available

Gene Snapshot

Ribosomal protein L23A (RpL23A) encodes an essential ribosomal RNA binding protein of the large ribosomal subunit involved in protein synthesis. [Date last reviewed: 2018-10-18]

Other Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

L23a

Key Links

Genomic Location

Cytogenetic map

62A10-62A10

Sequence location

3L:1,666,288..1,668,654 [-]

Recombination map

3-0.5

RefSeq locus

NT_037436 REGION:1666288..1668654

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (6 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables structural constituent of ribosome

inferred from high throughput direct assay

(Alonso and Santaren, 2006)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables structural constituent of ribosome

traceable author statement

(Marygold et al., 2007)

inferred from biological aspect of ancestor with PANTHER:PTN000178698

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (3 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in cytoplasmic translation

traceable author statement

(Marygold et al., 2007)

inferred by curator from GO:0022626

(Alonso and Santaren, 2006)

involved_in ribosomal large subunit assembly

inferred from biological aspect of ancestor with PANTHER:PTN000178698

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in translation

inferred from electronic annotation with InterPro:IPR012678, InterPro:IPR013025

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in cytosolic ribosome

inferred from high throughput direct assay

(Alonso and Santaren, 2006)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

part_of cytosolic large ribosomal subunit

traceable author statement

(Marygold et al., 2007)

inferred from biological aspect of ancestor with PANTHER:PTN000178698

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

CYTOPLASMIC LARGE RIBOSOMAL PROTEINS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

CYTOPLASMIC LARGE RIBOSOMAL PROTEINS -: Cytoplasmic ribosomes are found on the endoplasmic reticulum and in the cytoplasm. They translate all mRNAs produced from nuclear genes and perform the majority of cellular protein synthesis. Ribosomes are formed by two ribonucleoprotein subunits, large and small. The principle function of the large subunit is to bind tRNA during the synthesis of polypeptides. (Adapted from FBrf0205398).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\RpL23A for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.40

Gene model reviewed during 5.44

Gene model reviewed during 5.52

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 6.26

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

RpL23A-RA

FBtr0072805

NM_079162

1016

277

RpL23A-RB

FBtr0474640

NM_001370049

1321

277

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

RpL23A-PA

FBpp0072687

29.5

277

11.66

NP_523886

AAF47545

RpL23A-PB

FBpp0423205

29.5

277

11.66

QCD26215

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

277 aa isoforms: RpL23A-PA, RpL23A-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\RpL23A using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 13 -- 16

organism | ubiquitous

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

day 7 of adulthood -- day 49 of adulthood

adult heart

(Cammarato et al., 2011)

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in cytosolic ribosome

inferred from high throughput direct assay

(Alonso and Santaren, 2006)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\RpL23A in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\RpL23A

View exonic expression by tissue for Dmel\RpL23A

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0026372

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0026372

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG7977-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG7977

Flygut - An atlas of the Drosophila adult midgut

FBgn0026372

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 1 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 5 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of RpL23A

Transgenic constructs containing regulatory region of RpL23A

Deletions and Duplications ( 1 )

Disrupted in

Df(3L)ED4275

(Marygold et al., 2007)

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

RpL23A^f02629

Sterility

Allele

fertile

RpL23A^f02629

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\RPL23A

10 of 15

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (12)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Gm6096

7 of 15

Yes

Mmus\Rpl23a

6 of 15

Yes

Mmus\Gm10132

5 of 15

Yes

Mmus\Gm3940

3 of 15

Yes

Mmus\Gm10335

3 of 15

Yes

Mmus\Gm8290

2 of 15

Yes

Mmus\Gm10923

2 of 15

Yes

Mmus\Gm6177

1 of 15

Yes

Mmus\Gm8112

1 of 15

Yes

Mmus\Gm8137

1 of 15

Yes

Mmus\Gm8158

1 of 15

Yes

Mmus\Gm8264

1 of 15

Yes

Rattus norvegicus (Norway rat) (9)

Rnor\Rpl23a

10 of 13

Yes

Rnor\RGD1565170

3 of 13

Yes

Rnor\LOC299190

2 of 13

Yes

Rnor\RGD1565806

2 of 13

Yes

Rnor\LOC680441

1 of 13

Yes

Rnor\LOC689899

1 of 13

Yes

Rnor\LOC690335

1 of 13

Yes

Rnor\RGD1562755

1 of 13

Yes

Rnor\RGD1564606

1 of 13

Yes

Xenopus tropicalis (Western clawed frog) (1)

Xtro\rpl23a

10 of 12

Yes

Danio rerio (Zebrafish) (1)

Drer\rpl23a

7 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (2)

Cele\rpl-25.1

10 of 15

Yes

Cele\rpl-25.2

9 of 15

Yes

Arabidopsis thaliana (thale-cress) (4)

Atha\RPL23AA

7 of 9

Yes

Atha\RPL23AB

7 of 9

Yes

Atha\AT4G39880

1 of 9

Yes

Atha\rpl23

1 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\RPL25

10 of 15

Yes

Schizosaccharomyces pombe (Fission yeast) (2)

Spom\rpl2502

9 of 12

Yes

Spom\rpl2501

8 of 12

Yes

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190IFQ )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA20736

Drosophila persimilis

Dper\GL12432

Drosophila willistoni

Dwil\GK17068

Drosophila virilis

Dvir\GJ12535

Drosophila mojavensis

Dmoj\GI16793

Drosophila grimshawi

Dgri\GH15515

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150CA5 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17021189

Glossina morsitans

Tsetse fly

Gmor\GMOY011965

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_10722

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL017516

Anopheles gambiae

Malaria mosquito

Agam\Rpl24

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ000279

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0I50 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA006835

Danaus plexippus

Monarch butterfly

Dple\DPOGS206113-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL014068

Apis florea

Little honeybee

Aflo\2430735620

Apis mellifera

Western honey bee

Amel\RpL23A

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP25146

Bombus terrestris

Buff-tailed bumblebee

Bter\15208206

Linepithema humile

Argentine ant

Lhum\LH22940

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:001e40

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG007746

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_07983

Tribolium castaneum

Red flour beetle

Tcas\TC012708

Pediculus humanus

Human body louse

Phum\PHUM361800

Rhodnius prolixus

Kissing bug

Rpro\RPRC005724

Cimex lectularius

Bed bug

Clec\CLEC008966

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI007628

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_11393

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0I8E )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR000901

Ixodes scapularis

Black-legged tick

Isca\ISCW024803

Stegodyphus mimosarum

African social velvet spider

Smim\KFM59155.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur31g00650

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_314559

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0UYL )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_015284gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Rpl23a

Ciona intestinalis

Vase tunicate

Cint\LOC100176316

Gallus gallus

Domestic chicken

Ggal\RPL23A

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (0)

No records found.

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

RPL23A; ribosomal protein L23a

10 of 15

602326

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

RpL23A - Myc

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

RpL23A - Pi3K21B

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

RpL23A - Rack1

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL23A - Ras85D

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

RpL23A - RpL10

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL23A - RpL10Ab

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL23A - RpL11

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL23A - RpL12

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL23A - RpL13

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL23A - RpL13A

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL23A - RpL14

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL23A - RpL15

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL23A - RpL17

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL23A - RpL18

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL23A - RpL18A

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL23A - RpL19

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL23A - RpL21

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL23A - RpL22

cosedimentation, Identification by mass spectrometry, electron microscopy, anti bait coimmunoprecipitation, western blot

(Mageeney and Ware, 2019, Anger et al., 2013)

RpL23A - RpL22-like

anti bait coimmunoprecipitation, western blot

(Mageeney and Ware, 2019)

RpL23A - RpL23

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL23A - RpL24

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL23A - RpL26

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL23A - RpL27

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL23A - RpL27A

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL23A - RpL28

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL23A - RpL29

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL23A - RpL3

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL23A - RpL30

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL23A - RpL31

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL23A - RpL32

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL23A - RpL34a

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL23A - RpL35

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL23A - RpL35A

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL23A - RpL36

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL23A - RpL36A

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL23A - RpL37A

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL23A - RpL37a

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL23A - RpL38

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL23A - RpL39

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL23A - RpL4

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL23A - RpL40

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL23A - RpL41

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL23A - RpL5

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL23A - RpL6

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL23A - RpL7

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL23A - RpL7A

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL23A - RpL8

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL23A - RpL9

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL23A - RpLP0

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL23A - RpLP1

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL23A - RpLP2

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL23A - RpS10a

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL23A - RpS11

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL23A - RpS12

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL23A - RpS13

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL23A - RpS14a

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL23A - RpS14b

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL23A - RpS15

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL23A - RpS15Aa

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL23A - RpS16

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL23A - RpS17

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL23A - RpS18

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL23A - RpS19a

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL23A - RpS2

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL23A - RpS20

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL23A - RpS21

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL23A - RpS23

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL23A - RpS24

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL23A - RpS25

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL23A - RpS26

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL23A - RpS27

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL23A - RpS27A

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL23A - RpS28b

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL23A - RpS29

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL23A - RpS3

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL23A - RpS30

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL23A - RpS3A

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL23A - RpS4

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL23A - RpS5a

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL23A - RpS6

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL23A - RpS7

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL23A - RpS8

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL23A - RpS9

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL23A - S6kII

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

RpL23A - cnk

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

RpL23A - eEF2

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL23A - foxo

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

RpL23A - rictor

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

RpL23A - sima

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

RpL23A - sta

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpL23A - vig2

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RNA-protein

Physical Interaction

Assay

References

RpL23A - 18SrRNA

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL23A - 28SrRNA

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL23A - 2SrRNA

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL23A - 5.8SrRNA

cosedimentation, electron microscopy

(Anger et al., 2013)

RpL23A - 5SrRNA

cosedimentation, electron microscopy

(Anger et al., 2013)

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

63742

DroID - A comprehensive database of gene and protein interactions.

FBgn0026372

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

38208

MIST (protein-protein) - An integrated Molecular Interaction Database

RpL23A

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Ribosome

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-0.5

Cytogenetic map

62A10-62A10

Sequence location

3L:1,666,288..1,668,654 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

62A10-62A10

Limits computationally determined from genome sequence between P{EP}rho^EP3704&P{PZ}l(3)06226⁰⁶²²⁶ and P{PZ}dlt⁰⁴²⁷⁶

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

62C-62C

(determined by in situ hybridisation)

(Hursh, 1995.7.5)

Experimentally Determined Recombination Data

Location

3-0.5

(FlyBase, 2016)

3-2.5

(Comeron et al., 2012)

(Hursh, 1995.7.5)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (5)

Bloomington

18568

w¹¹¹⁸; PBac{WH}RpL23A^f02629

51818

y¹ sc^* v¹ sev²¹; P{TRiP.HMC03389}attP2

FlyORF

F001369

M{UAS-RpL23A.ORF}ZH-86Fb

F000974

M{UAS-RpL23A.ORF.3xHA}ZH-86Fb

VDRC

v101337

P{KK107646}VIE-260B

Genomic Clones (21)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (1215)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

FI01658

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0026372

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0026372

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

38208

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for database merge of

Source for merge of: RpL23a anon- EST:fe2D1

(Bayraktaroglu, 2000.11.2)

Source for merge of: RpL23a RpL25

(Luschnig, 2003.6.11)

Source for merge of: RpL23A anon- EST:Liang-1.4

(Ashburner, 2004.6.30)

Additional comments

"RpL23A" likely corresponds to "M(3)62A".

(Marygold et al., 2007)

FlyBase curator comment: the insertion in the "e04143" Exelixis line (PBac{RB}RabX5^e04143) was originally assigned to the RpL23A gene in FBrf0179797, resulting in the "RpL23A^e04143" (FBal0159876) allele. However, FBrf0184340 shows that the insertion is actually within RabX5.

(Bloomington Drosophila Stock Center, 2004.11.6)

Other Comments

Haploinsufficient locus.

(Cook et al., 2012)

Likely Minute gene.

(Marygold et al., 2007)

Deletions removing RpL23A but no other cytoplasmic ribosomal protein-encoding genes show Minute phenotypes.

(Marygold et al., 2007)

Identification: Protein that interacts with the AM domain of Parp protein.

(Koyama et al., 1999)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 53 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

38208

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0026372

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0026372

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG7977

Flygut - An atlas of the Drosophila adult midgut

FBgn0026372

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

38208

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG7977

modMine - A data warehouse for the modENCODE project

FBgn0026372

Linkouts

BioGRID - A database of protein and genetic interactions.

63742

DroID - A comprehensive database of gene and protein interactions.

FBgn0026372

DRSC - Results frm RNAi screens

FBgn0026372

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0026372

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG7977-RA

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0026372

FlyMine - An integrated database for Drosophila genomics

FBgn0026372

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

38208

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Ribosome

MIST (protein-protein) - An integrated Molecular Interaction Database

RpL23A

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synonyms and Secondary IDs (21)

Reported As

Symbol Synonym

153215_at

(Kristensen et al., 2005)

CG7977

(Kolkhof et al., 2017, Rosa-Ferreira et al., 2015, Fukuoh et al., 2014, Schertel et al., 2013, Cammarato et al., 2011, Müller et al., 2010, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Marygold et al., 2007, Ashburner, 2004.6.30)

L23A

(Carpenter et al., 2009)

L23a

(Miwa et al., 2020, Ross et al., 2007, Eastman and Ware, 2001)

PBP-3

(Koyama et al., 1999)

RPL23a

(Pinnola et al., 2007)

Rp L23A

(Alonso and Santaren, 2006)

RpL23a

(Wang and DiMario, 2017, Aradska et al., 2015, Wang et al., 2004, Luschnig, 2003.6.11, Koyama et al., 1999)

RpL25

anon-EST:Liang-1.4

anon-EST:fe2D1

clone 1.4

(Liang and Biggin, 1998)

eRpL23a

(Mageeney and Ware, 2019)

rpL25

(Dooijes et al., 1998)

rpl23a

(Koyama, 1998.7.24)

Name Synonyms

PARP-binding protein-3

(Koyama et al., 1999)

Ribosomal protein L23A

(Cammarato et al., 2011, Ashburner and Marygold, 2004.7.2)

Ribosomal protein L23a

(Koyama et al., 1999)

Ribosomal protein L25

anon-fast-evolving-2D1

Secondary FlyBase IDs

FBgn0014878
FBgn0025226
FBgn0025992

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (77)

The following external sites may use different assemblies or annotations than FlyBase.

Report Sections