FlyBase Gene Report: Dmel\RhoGAPp190

General Information

Symbol

Dmel\RhoGAPp190

Species

D. melanogaster

Name

Rho GTPase activating protein p190

Annotation Symbol

CG32555

Feature Type

protein_coding_gene

FlyBase ID

FBgn0026375

Gene Model Status

Current

Stock Availability

27 publicly available

Gene Summary

Rho GTPase activating protein p190 (RhoGAPp190) encodes a Rho GTPase activating protein that binds the semaphorin receptor and regulates axonogenesis. [Date last reviewed: 2019-08-01] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

p190RhoGAP, p190 RhoGAP, p190, RhoGAP

Key Links

Genomic Location

Cytogenetic map

16B10-16B10

Sequence location

X:17,639,147..17,652,562 [-]

Recombination map

1-57

RefSeq locus

NC_004354 REGION:17639147..17652562

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (12 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables GTPase activator activity

inferred from genetic interaction with FLYBASE:Rho1; FB:FBgn0014020

(Billuart et al., 2001)

enables semaphorin receptor binding

inferred from physical interaction with FLYBASE:Sema1a; FB:FBgn0011259

(Jeong et al., 2012)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables GTP binding

inferred from electronic annotation with InterPro:IPR001806

(InterPro Project Members, 2004-)

enables GTPase activator activity

inferred from biological aspect of ancestor with PANTHER:PTN002508977

(GO Reference Genome Project, 2011-)

enables GTPase activity

inferred from electronic annotation with InterPro:IPR001806

(InterPro Project Members, 2004-)

Biological Process (7 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

involved_in defasciculation of motor neuron axon

inferred from mutant phenotype

(Jeong et al., 2012)

involved_in mushroom body development

inferred from mutant phenotype

(Billuart et al., 2001)

involved_in negative regulation of cell size

inferred from mutant phenotype

(Jeong et al., 2012)

involved_in regulation of axonogenesis

inferred from genetic interaction with FLYBASE:LIMK1; FB:FBgn0283712

(Ng and Luo, 2004)

involved_in Rho protein signal transduction

inferred from genetic interaction with FLYBASE:Rho1; FB:FBgn0014020

(Billuart et al., 2001)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

involved_in regulation of axonogenesis

inferred from biological aspect of ancestor with PANTHER:PTN000571300

(GO Reference Genome Project, 2011-)

involved_in regulation of cell size

inferred from biological aspect of ancestor with PANTHER:PTN002508977

(GO Reference Genome Project, 2011-)

involved_in Rho protein signal transduction

inferred from biological aspect of ancestor with PANTHER:PTN002508977

(GO Reference Genome Project, 2011-)

involved_in signal transduction

inferred from electronic annotation with InterPro:IPR000198

(InterPro Project Members, 2004-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in cytosol

inferred from biological aspect of ancestor with PANTHER:PTN002508977

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

RHO GTPASE ACTIVATING PROTEINS

Protein Family (UniProt)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

GTPase activity
RHEA 19669:

Summaries

Gene Snapshot

Rho GTPase activating protein p190 (RhoGAPp190) encodes a Rho GTPase activating protein that binds the semaphorin receptor and regulates axonogenesis. [Date last reviewed: 2019-08-01]

Gene Group (FlyBase)

RHO GTPASE ACTIVATING PROTEINS -: RhoGAPs are GTPase activating proteins for Rho family GTPases. (Adapted from PMID:15731001 and FBrf0158741).

Protein Function (UniProtKB)

GTPase-activating protein (GAP) for RhoA/Rho1 that plays an essential role in the stability of dorsal branches of mushroom body (MB) neurons. The MB neurons are the center for olfactory learning and memory. Acts by converting RhoA/Rho1 to an inactive GDP-bound state, leading to repress the RhoA/Rho1-Drok-MRLC signaling pathway thereby maintaining axon branch stability. ACTIVITY REGULATION: Negatively regulated by integrin, bsk and Src/Src64B.

(UniProt, Q9VX32)

Summary (Interactive Fly)

part of an axon retraction pathway from Rho to myosin in mature neurons - inactivation of RhoGAP leads to axon retraction

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\RhoGAPp190 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VX32)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.51

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated.

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

RhoGAPp190-RA

FBtr0074483

NM_167572

7348

1561

RhoGAPp190-RB

FBtr0074481

NM_133003

5872

1561

RhoGAPp190-RC

FBtr0074482

NM_167573

7639

1561

RhoGAPp190-RD

FBtr0333659

NM_001272727

7301

1564

RhoGAPp190-RE

FBtr0333660

NM_001272728

7693

1579

RhoGAPp190-RF

FBtr0333661

NM_001272729

7411

1621

RhoGAPp190-RG

FBtr0333662

NM_001272730

6742

1398

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

RhoGAPp190-PA

FBpp0074257

178.8

1561

5.26

FBpp0074255

178.8

1561

5.26

FBpp0074256

178.8

1561

5.26

FBpp0305815

179.1

1564

5.32

FBpp0305816

180.6

1579

5.23

FBpp0305817

185.2

1621

5.18

FBpp0305818

161.2

1398

5.36

M9PJQ3

NP_001259659

AGB95501

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1561 aa isoforms: RhoGAPp190-PA, RhoGAPp190-PB, RhoGAPp190-PC

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\RhoGAPp190 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.89

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

prepupal stage P3

leg joint

Comment: elevated level

(Greenberg and Hatini, 2011)

leg | ubiquitous

(Greenberg and Hatini, 2011)

Additional Descriptive Data

Expression in stage P3 pupal leg discs is ubiquitous but is elevated in the joints.

(Greenberg and Hatini, 2011)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\RhoGAPp190 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\RhoGAPp190

View exonic expression by tissue for Dmel\RhoGAPp190

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0026375

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

32743/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0026375

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0026375

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0026375

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG32555

Flygut - An atlas of the Drosophila adult midgut

FBgn0026375

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 15 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 12 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of RhoGAPp190

Transgenic constructs containing regulatory region of RhoGAPp190

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 22 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^αTub84B.PL

RhoGAPp190^RNAi.GAP.UAS

viable

RhoGAPp190^EY08765

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^pnr-MD237

viable, with Scer\GAL4^tin.CΔ4

Sterility

Allele

fertile

RhoGAPp190^EY08765

Other Phenotypes

Allele

abnormal body color, with Scer\GAL4^pnr-MD237

RhoGAPp190^GD13868

abnormal cell migration | oogenesis, with Scer\GAL4^slbo.2.6

RhoGAPp190^JF01520

abnormal neuroanatomy, with Scer\GAL4^ey-OK107

abnormal neuroanatomy | embryonic stage

RhoGAPp190²

abnormal neuroanatomy | embryonic stage, with Scer\GAL4^elav.PLu

RhoGAPp190^RNAi.N.UAS

Phenotype manifest in

Allele

adult mushroom body, with Scer\GAL4^ey-OK107

RhoGAPp190^UAS.Tag:MYC

adult mushroom body beta-lobe, with Scer\GAL4^ey-OK107

RhoGAPp190^RNAi.GAP.UAS

border follicle cell, with Scer\GAL4^slbo.2.6

RhoGAPp190^JF01520

larval intersegmental nerve branch ISNb of A1-7

RhoGAPp190²

larval intersegmental nerve branch ISNb of A1-7, with Scer\GAL4^elav.PLu

RhoGAPp190^RNAi.N.UAS

medial lobe & axon, with Scer\GAL4^ey-OK107

RhoGAPp190^RNAi.GAP.UAS

mesonotum, with Scer\GAL4^pnr-MD237

RhoGAPp190^GD13868

vertical lobe of adult mushroom body, with Scer\GAL4^ey-OK107

wing hair | increased number, with Scer\GAL4^ptc-559.1

RhoGAPp190^UAS.Tag:MYC

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (9)

Hsap\ARHGAP5

12 of 14

Yes

Hsap\ARHGAP35

12 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (5)

Rnor\Arhgap35

13 of 14

Yes

Rnor\Arhgap5

12 of 14

Yes

Rnor\LOC304239

1 of 14

Rnor\Ralbp1

1 of 14

Rnor\Syde1

1 of 14

Mus musculus (laboratory mouse) (4)

Mmus\Arhgap5

12 of 14

Yes

Mmus\Arhgap35

12 of 14

Yes

Mmus\Ralbp1

1 of 14

Mmus\Syde1

1 of 14

Xenopus tropicalis (Western clawed frog) (5)

Xtro\arhgap35

11 of 13

Yes

Xtro\arhgap5

10 of 13

Yes

Xtro\arhgap22

1 of 13

Yes

Xtro\dph3

1 of 13

Xtro\ralbp1

1 of 13

Danio rerio (Zebrafish) (4)

Drer\arhgap35a

13 of 14

Yes

Drer\arhgap35b

13 of 14

Yes

Drer\arhgap5

11 of 14

Yes

Drer\ralbp1

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (2)

Cele\rga-5

11 of 14

Yes

Cele\rlbp-1

1 of 14

Anopheles gambiae (African malaria mosquito) (2)

Agam\AgaP_AGAP000870

12 of 12

Yes

Agam\AgaP_AGAP003146

1 of 12

Arabidopsis thaliana (thale-cress) (4)

Atha\AT5G12150

1 of 13

Yes

Atha\AT5G19390

1 of 13

Yes

Atha\AT5G61530

1 of 13

Yes

Atha\REN1

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:RhoGAPp190. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (2)

RhoGAP102A

1 of 13

Rlip

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 2 )

Allele

Disease

Interaction

References

RhoGAPp190^EP1357

exacerbates Huntington's disease

modeled by Hsap\HTT^{128Q.1-336.UAS}

(Branco et al., 2008)

exacerbates olivopontocerebellar atrophy

modeled by Hsap\ATXN1^82Q.UAS

(Branco et al., 2008)

RhoGAPp190^RNAi.N.UAS

ameliorates amyotrophic lateral sclerosis type 10

modeled by TBPH^Δ23, TBPH^GD6943

(Langellotti et al., 2018)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

ARHGAP5; Rho GTPase activating protein 5

12 of 14

602680

ARHGAP35; Rho GTPase activating protein 35

12 of 14

605277

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

RNA-protein

Physical Interaction

Assay

References

RhoGAPp190 - TBPH

pull down, quantitative reverse transcription pcr, anti tag coimmunoprecipitation

(Langellotti et al., 2018)

protein-protein

Physical Interaction

Assay

References

RhoGAPp190 - PlexA

anti tag coimmunoprecipitation, anti tag western blot

(Jeong et al., 2012)

RhoGAPp190 - PlexB

anti tag coimmunoprecipitation, anti tag western blot

(Jeong et al., 2012)

RhoGAPp190 - Sema1a

anti bait coimmunoprecipitation, anti tag western blot, anti tag coimmunoprecipitation

(Jeong et al., 2012)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

RhoGAPp190

suppressible

mys

(Billuart et al., 2001)

RhoGAPp190

suppressible

pbl

(Jeong et al., 2012)

RhoGAPp190

enhanceable

Rho1

(Billuart et al., 2001)

RhoGAPp190

suppressible

Sema1a

(Jeong et al., 2012)

RhoGAPp190

suppressible

sqh

(Billuart et al., 2001)

RhoGAPp190

enhanceable

sqh

(Billuart et al., 2001)

RhoGAPp190

suppressible

Src64B

(Billuart et al., 2001)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

LIMK1

suppressible

RhoGAPp190

(Chen et al., 2004, Ng and Luo, 2004)

mwh

enhanceable

RhoGAPp190

(Yan et al., 2009)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

59069

DroID - A comprehensive database of gene and protein interactions.

FBgn0026375

MIST (genetic) - An integrated Molecular Interaction Database

32743

MIST (protein-protein) - An integrated Molecular Interaction Database

32743

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-57

Cytogenetic map

16B10-16B10

Sequence location

X:17,639,147..17,652,562 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

16B10-16B10

Limits computationally determined from genome sequence between P{EP}baz^EP1446 and P{EP}EP1464

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

1-57

(FlyBase, 2016)

1-58.1

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (27)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

49951

w¹¹¹⁸; P{GMR37C02-GAL4}attP2

49965

w¹¹¹⁸; P{GMR37G02-GAL4}attP2

69403

w¹¹¹⁸; P{R37C02-GAL4.DBD}attP2

69475

w¹¹¹⁸; P{R37G02-GAL4.DBD}attP2

52761

w¹¹¹⁸; P{GMR37C02-lexA}attP40/CyO

43987

y¹ v¹; P{TRiP.HMJ02052}attP40

Korea

10756

P{EP}RhoGAPp190^G1116

11287

P{EP}RhoGAPp190^G10390

11304

P{EP}RhoGAPp190^G10464

11430

P{EP}RhoGAPp190^G11058

VDRC

v110213

P{KK102627}VIE-260B

v28877

w¹¹¹⁸; P{GD13856}v28877

More stocks available...

Genomic Clones (12)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (141)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0026375

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0026375

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Sema-1a-mediated motor axon defasciculation is promoted by pbl and inhibited by RhoGAPp190. The opposing pbl and RhoGAPp190 functions mediate Sema-1a reverse signaling through the regulation of Rho1 activity.

(Jeong et al., 2012)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Inactivation of RhoGAPp190 results in axon retraction in the mushroom body.

(Billuart et al., 2001)

Relationship to Other Genes

Source for database merge of

Source for merge of: RhoGAPp190 BcDNA:GM05133

(FlyBase, 1996-)

Source for merge of: RhoGAPp190 BcDNA:GH17919

(FlyBase, 1996-)

Additional comments

Annotations CG8240, CG8267 merged as CG32555 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Source for identity of RhoGAP CG8240 CG8267 was sequence comparison ( date:011104 ).

(FlyBase, 1996-)

Source for merge of RhoGAPp190 BcDNA:GM05133 was a shared cDNA ( date:030728 ).

(FlyBase, 1996-)

Source for merge of RhoGAPp190 BcDNA:GH17919 was a shared cDNA ( date:030728 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: RhoGAP CG8240 CG8267

(FlyBase, 1996-)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (20)

Reported As

Symbol Synonym

8267

(Hu et al., 2005)

BcDNA:GH17919

BcDNA:GM05133

CG32555

(Greenberg and Hatini, 2011, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Ni et al., 2008, Larschan et al., 2007, Larschan et al., 2007)

CG8240

(Bernards, 2003, Billuart et al., 2001)

CG8267

(Hu, 2005, Bernards, 2003, Billuart et al., 2001)

D-p190

(Billuart et al., 2001)

DRhoGAP

(Sotillos and Campuzano, 1999)

RhoGAP

(Sailem et al., 2014)

RhoGAP P190

(Yan et al., 2009)

RhoGAP-16B12

(Billuart et al., 2001)

RhoGap190

(Sharma et al., 2020)

mdcds_56566

(Chen and Oliver, 2014.8.15)

p190

(Hernandez-Fleming et al., 2017, Battistini and Tamagnone, 2016, Jeong et al., 2012)

p190 RhoGAP

(Govek et al., 2005, Piekny et al., 2005, Leslie, 2001)

p190-RhoGAP

(Oliva and Sierralta, 2010)

p190RhoGAP

(Stiegler and Boggon, 2017, Bakal et al., 2008, Bakal et al., 2007, Ng and Luo, 2004, Bokel and Brown, 2002)

Name Synonyms

Rho GTPase activating protein p190

RhoGAPp190

(Branco et al., 2008)

Rp190RhoGAP

(Chen et al., 2004)

Secondary FlyBase IDs

FBgn0030856
FBgn0030857
FBgn0046792
FBgn0052555
FBgn0062491

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 101 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

32743

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VX32

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9VX32

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VX32

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0026375

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

32743/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0026375

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0026375

FlyMine - An integrated database for Drosophila genomics

FBgn0026375

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG32555

MARRVEL_MODEL - MARRVEL (model organism gene)

32743

Linkouts

BioGRID - A database of protein and genetic interactions.

59069

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0026375

DroID - A comprehensive database of gene and protein interactions.

FBgn0026375

DRSC - Results frm RNAi screens

FBgn0026375

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0026375

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0026375

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG32555

Flygut - An atlas of the Drosophila adult midgut

FBgn0026375

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC004583

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (genetic) - An integrated Molecular Interaction Database

32743

MIST (protein-protein) - An integrated Molecular Interaction Database

32743

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (87)

The following external sites may use different assemblies or annotations than FlyBase.

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