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Gene Dmel\Rep

General Information
Symbol	Dmel\Rep	Species	D. melanogaster
Name	Rab escort protein	Annotation symbol	CG8432
Feature type	protein_coding_gene	FlyBase ID	FBgn0026378
Gene Model Status	Current	Stock availability	6 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	56D13-56D13	Sequence location	2R:15,379,592..15,381,630 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Rab escort protein is referred to in FlyBase by the symbol Dmel\Rep (CG8432, FBgn0026378). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: Rab GTPase binding; Rab geranylgeranyltransferase activity. It is reported to be involved in the biological process: neurotransmitter secretion; vesicle-mediated transport. 4 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: GDP dissociation inhibitor; Rab protein geranylgeranyltransferase component A, eukaryota. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-06 and 18-24 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult crop, adult midgut, larval hindgut, larval/adult Malpighian tubules, adult salivary gland, larval trachea, adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1631388_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Rep. Gene sequence location is 2R:15379592..15381630.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 56D13-56D13   Limits computationally determined from genome sequence between P{lacW}l(2)k00705k00705&P{lacW}mei-W68k05603 and P{EP}CG11007EP736
Experimentally Determined Cytological Location
Cytogenetic map Notes References 56E-56E     (Dong, 1998.11.7) 56E-56E   (determined by in situ hybridisation)   (Dong et al., 1999) 56D-56E   Determined by comparing Celera genomic sequence with sequence from BDGP BAC and P1 clones.   (Lloyd et al., 2000)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Rep for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.45
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Rep-RA FBtr0086462  NM_058072   1923   511
Additional Transcript Data & Comments
Reported size (kB)	1.955 (compiled cDNA) (Dong et al., 1999)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Rep-PA   FBpp0085658   56.8   511   4.55     NP_477420   AAF57544
Additional Polypeptide Data & Comments
Reported size (kDa)	511 (aa); 60 (kD observed); 56.855 (kD predicted) (Dong et al., 1999)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • GDP dissociation inhibitor (IPR018203) Rab protein geranylgeranyltransferase component A, eukaryota (IPR016664)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202509   AA390716   AA816277   AE013599 AAF57544   AC004311   AF105063 AAD16891   AI404930   AI455247   AI456925   AW941494   AY061052 AAL28600   BI216775   BI482085   BI483743   BI486241   BI578828   CO189920   CO268575   CO268588   CO314428   CO332674   CO344225   CZ483981   EC058177   EC079274   EC082508   EC086943   EC233770   EC265190
UniProtKB/Swiss-Prot	Q9V8W3
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
	In syncytial blastoderm embryos, Rep protein localizes to the nucleus and chromosome throughout the cell cycle. At prophase, the protein localizes in a punctate pattern around the nuclei, and during metaphase is divided equally to the spindle poles. At telophase, the nuclei reform with Rep protein associated with each nucleus. (Dong et al., 1999)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
aster inferred from direct assay (assigned by UniProtKB) (Dong et al., 1999) perinuclear region of cytoplasm inferred from direct assay (assigned by UniProtKB) (Dong et al., 1999) spindle pole inferred from direct assay (assigned by UniProtKB) (Dong et al., 1999)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult crop, adult midgut, larval hindgut, larval/adult Malpighian tubules, adult salivary gland, larval trachea, adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    115.975 Larval Midgut    95.6 Larval Hindgut    118.9 Larval Malpighian Tubules    134.3 Larval Fat Body    46.7 Larval Salivary Gland    63.9 Larval Trachea    113.175 Larval Carcass    77.625 Adult Head    68.3 Adult Eye    49.375 Adult Brain    97.9 Adult Thoracic-Abdominal Ganglion    142.2 Adult Crop    105 Adult Midgut    117.3 Adult Hindgut    93.2 Adult Malpighian Tubules    150.3 Adult Fat Body    68 Adult Salivary Gland    131.3 Adult Heart    79.55 Adult VirginFemale Spermatheca    50.9 Adult InseminatedFemale Spermatheca    67.3 Adult Ovary    131 Adult Testis    11.2 Adult Male Accessory Gland    68.1 Adult Carcass    51.3 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    115.975 Larval Midgut    95.6 Larval Hindgut    118.9 Larval Malpighian Tubules    134.3 Larval Fat Body    46.7 Larval Salivary Gland    63.9 Larval Trachea    113.175 Larval Carcass    77.625 Adult Head    68.3 Adult Eye    49.375 Adult Brain    97.9 Adult Thoracic-Abdominal Ganglion    142.2 Adult Crop    105 Adult Midgut    117.3 Adult Hindgut    93.2 Adult Malpighian Tubules    150.3 Adult Fat Body    68 Adult Salivary Gland    131.3 Adult Heart    79.55 Adult VirginFemale Spermatheca    50.9 Adult InseminatedFemale Spermatheca    67.3 Adult Ovary    131 Adult Testis    11.2 Adult Male Accessory Gland    68.1 Adult Carcass    51.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    115.975 Larval Midgut    95.6 Larval Hindgut    118.9 Larval Malpighian Tubules    134.3 Larval Fat Body    46.7 Larval Salivary Gland    63.9 Larval Trachea    113.175 Larval Carcass    77.625 Adult Head    68.3 Adult Eye    49.375 Adult Brain    97.9 Adult Thoracic-Abdominal Ganglion    142.2 Adult Crop    105 Adult Midgut    117.3 Adult Hindgut    93.2 Adult Malpighian Tubules    150.3 Adult Fat Body    68 Adult Salivary Gland    131.3 Adult Heart    79.55 Adult VirginFemale Spermatheca    50.9 Adult InseminatedFemale Spermatheca    67.3 Adult Ovary    131 Adult Testis    11.2 Adult Male Accessory Gland    68.1 Adult Carcass    51.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    115.975 Larval Midgut    95.6 Larval Hindgut    118.9 Larval Malpighian Tubules    134.3 Larval Fat Body    46.7 Larval Salivary Gland    63.9 Larval Trachea    113.175 Larval Carcass    77.625 Adult Head    68.3 Adult Eye    49.375 Adult Brain    97.9 Adult Thoracic-Abdominal Ganglion    142.2 Adult Crop    105 Adult Midgut    117.3 Adult Hindgut    93.2 Adult Malpighian Tubules    150.3 Adult Fat Body    68 Adult Salivary Gland    131.3 Adult Heart    79.55 Adult VirginFemale Spermatheca    50.9 Adult InseminatedFemale Spermatheca    67.3 Adult Ovary    131 Adult Testis    11.2 Adult Male Accessory Gland    68.1 Adult Carcass    51.3 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    115.975 Larval Midgut    95.6 Larval Hindgut    118.9 Larval Malpighian Tubules    134.3 Larval Fat Body    46.7 Larval Salivary Gland    63.9 Larval Trachea    113.175 Larval Carcass    77.625 Adult Head    68.3 Adult Eye    49.375 Adult Brain    97.9 Adult Thoracic-Abdominal Ganglion    142.2 Adult Crop    105 Adult Midgut    117.3 Adult Hindgut    93.2 Adult Malpighian Tubules    150.3 Adult Fat Body    68 Adult Salivary Gland    131.3 Adult Heart    79.55 Adult VirginFemale Spermatheca    50.9 Adult InseminatedFemale Spermatheca    67.3 Adult Ovary    131 Adult Testis    11.2 Adult Male Accessory Gland    68.1 Adult Carcass    51.3 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    115.975 Larval Midgut    95.6 Larval Hindgut    118.9 Larval Malpighian Tubules    134.3 Larval Fat Body    46.7 Larval Salivary Gland    63.9 Larval Trachea    113.175 Larval Carcass    77.625 Adult Head    68.3 Adult Eye    49.375 Adult Brain    97.9 Adult Thoracic-Abdominal Ganglion    142.2 Adult Crop    105 Adult Midgut    117.3 Adult Hindgut    93.2 Adult Malpighian Tubules    150.3 Adult Fat Body    68 Adult Salivary Gland    131.3 Adult Heart    79.55 Adult VirginFemale Spermatheca    50.9 Adult InseminatedFemale Spermatheca    67.3 Adult Ovary    131 Adult Testis    11.2 Adult Male Accessory Gland    68.1 Adult Carcass    51.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    115.975 Larval Midgut    95.6 Larval Hindgut    118.9 Larval Malpighian Tubules    134.3 Larval Fat Body    46.7 Larval Salivary Gland    63.9 Larval Trachea    113.175 Larval Carcass    77.625 Adult Head    68.3 Adult Eye    49.375 Adult Brain    97.9 Adult Thoracic-Abdominal Ganglion    142.2 Adult Crop    105 Adult Midgut    117.3 Adult Hindgut    93.2 Adult Malpighian Tubules    150.3 Adult Fat Body    68 Adult Salivary Gland    131.3 Adult Heart    79.55 Adult VirginFemale Spermatheca    50.9 Adult InseminatedFemale Spermatheca    67.3 Adult Ovary    131 Adult Testis    11.2 Adult Male Accessory Gland    68.1 Adult Carcass    51.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    115.975 Larval Midgut    95.6 Larval Hindgut    118.9 Larval Malpighian Tubules    134.3 Larval Fat Body    46.7 Larval Salivary Gland    63.9 Larval Trachea    113.175 Larval Carcass    77.625 Adult Head    68.3 Adult Eye    49.375 Adult Brain    97.9 Adult Thoracic-Abdominal Ganglion    142.2 Adult Crop    105 Adult Midgut    117.3 Adult Hindgut    93.2 Adult Malpighian Tubules    150.3 Adult Fat Body    68 Adult Salivary Gland    131.3 Adult Heart    79.55 Adult VirginFemale Spermatheca    50.9 Adult InseminatedFemale Spermatheca    67.3 Adult Ovary    131 Adult Testis    11.2 Adult Male Accessory Gland    68.1 Adult Carcass    51.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    68.3   NA  Eye    49.375   NA  Brain    97.9   115.975  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    142.2   NA  Crop    105   95.6  Midgut    117.3   118.9  Hindgut    93.2   134.3  Malpighian Tubules    150.3   no informative data  Fat Body    68   63.9  Salivary Gland    131.3   NA  Heart    79.55   113.175  Trachea    NA   NA  VirginFemale Spermatheca    50.9   NA  InseminatedFemale Spermatheca    67.3   NA  Ovary    131   NA  Testis    no informative data   NA  Male Accessory Gland    68.1   77.625  Carcass    51.3 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3    4 central nervous system, pupae P8    4 head, virgin 1-day female    2 head, virgin 4-day female    1 head, virgin 20-day female    4 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    3 head, mated 4-day male    3 head, mated 20-day male    4 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    4 digestive system, 4-day adult    4 digestive system, 20-day adult    5 fat body, larvae L3 wandering    1 fat body, white prepupae    2 fat body, pupae P8    3 carcass, larvae L3 wandering    5 carcass, 1-day adult    3 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    9 ovary, mated 4-day female    6 testis, mated 4-day male    1 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3    4 central nervous system, pupae P8    4 head, virgin 1-day female    2 head, virgin 4-day female    1 head, virgin 20-day female    4 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    3 head, mated 4-day male    3 head, mated 20-day male    4 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    4 digestive system, 4-day adult    4 digestive system, 20-day adult    5 fat body, larvae L3 wandering    1 fat body, white prepupae    2 fat body, pupae P8    3 carcass, larvae L3 wandering    5 carcass, 1-day adult    3 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    9 ovary, mated 4-day female    6 testis, mated 4-day male    1 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3    4 central nervous system, pupae P8    4 head, virgin 1-day female    2 head, virgin 4-day female    1 head, virgin 20-day female    4 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    3 head, mated 4-day male    3 head, mated 20-day male    4 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    4 digestive system, 4-day adult    4 digestive system, 20-day adult    5 fat body, larvae L3 wandering    1 fat body, white prepupae    2 fat body, pupae P8    3 carcass, larvae L3 wandering    5 carcass, 1-day adult    3 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    9 ovary, mated 4-day female    6 testis, mated 4-day male    1 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3    4 central nervous system, pupae P8    4 head, virgin 1-day female    2 head, virgin 4-day female    1 head, virgin 20-day female    4 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    3 head, mated 4-day male    3 head, mated 20-day male    4 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    4 digestive system, 4-day adult    4 digestive system, 20-day adult    5 fat body, larvae L3 wandering    1 fat body, white prepupae    2 fat body, pupae P8    3 carcass, larvae L3 wandering    5 carcass, 1-day adult    3 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    9 ovary, mated 4-day female    6 testis, mated 4-day male    1 accessory gland, mated 4-day male    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3    4 central nervous system, pupae P8    4 head, virgin 1-day female    2 head, virgin 4-day female    1 head, virgin 20-day female    4 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    3 head, mated 4-day male    3 head, mated 20-day male    4 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    4 digestive system, 4-day adult    4 digestive system, 20-day adult    5 fat body, larvae L3 wandering    1 fat body, white prepupae    2 fat body, pupae P8    3 carcass, larvae L3 wandering    5 carcass, 1-day adult    3 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    9 ovary, mated 4-day female    6 testis, mated 4-day male    1 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3    4 central nervous system, pupae P8    4 head, virgin 1-day female    2 head, virgin 4-day female    1 head, virgin 20-day female    4 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    3 head, mated 4-day male    3 head, mated 20-day male    4 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    4 digestive system, 4-day adult    4 digestive system, 20-day adult    5 fat body, larvae L3 wandering    1 fat body, white prepupae    2 fat body, pupae P8    3 carcass, larvae L3 wandering    5 carcass, 1-day adult    3 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    9 ovary, mated 4-day female    6 testis, mated 4-day male    1 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3    4 central nervous system, pupae P8    4 head, virgin 1-day female    2 head, virgin 4-day female    1 head, virgin 20-day female    4 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    3 head, mated 4-day male    3 head, mated 20-day male    4 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    4 digestive system, 4-day adult    4 digestive system, 20-day adult    5 fat body, larvae L3 wandering    1 fat body, white prepupae    2 fat body, pupae P8    3 carcass, larvae L3 wandering    5 carcass, 1-day adult    3 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    9 ovary, mated 4-day female    6 testis, mated 4-day male    1 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    4 central nervous system, larvae L3    4 central nervous system, pupae P8    4 head, virgin 1-day female    2 head, virgin 4-day female    1 head, virgin 20-day female    4 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    3 head, mated 4-day male    3 head, mated 20-day male    4 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    4 digestive system, 4-day adult    4 digestive system, 20-day adult    5 fat body, larvae L3 wandering    1 fat body, white prepupae    2 fat body, pupae P8    3 carcass, larvae L3 wandering    5 carcass, 1-day adult    3 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    9 ovary, mated 4-day female    6 testis, mated 4-day male    1 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-06 and 18-24 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    28 embryo 02-04hr    35 embryo 04-06hr    32 embryo 06-08hr    15 embryo 08-10hr    16 embryo 10-12hr    15 embryo 12-14hr    13 embryo 14-16hr    15 embryo 16-18hr    16 embryo 18-20hr    17 embryo 20-22hr    21 embryo 22-24hr    24 larva L1    9 larva L2    10 larva L3 12hr old    8 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    15 white prepupae new    15 white prepupae 12hr    11 white prepupae 24hr    11 pupae 2d postWPP    9 pupae 3d postWPP    7 pupae 4d postWPP    7 adult male 01day    7 adult male 05day    7 adult male 30day    7 adult female 01day    10 adult female 05day    16 adult female 30day    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (28) embryo 02-04hr  (35) embryo 04-06hr  (32) embryo 06-08hr    15 embryo 08-10hr    16 embryo 10-12hr    15 embryo 12-14hr    13 embryo 14-16hr    15 embryo 16-18hr    16 embryo 18-20hr    17 embryo 20-22hr    21 embryo 22-24hr    24 larva L1    9 larva L2    10 larva L3 12hr old    8 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    15 white prepupae new    15 white prepupae 12hr    11 white prepupae 24hr    11 pupae 2d postWPP    9 pupae 3d postWPP    7 pupae 4d postWPP    7 adult male 01day    7 adult male 05day    7 adult male 30day    7 adult female 01day    10 adult female 05day    16 adult female 30day    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    28 embryo 02-04hr    35 embryo 04-06hr    32 embryo 06-08hr    15 embryo 08-10hr    16 embryo 10-12hr    15 embryo 12-14hr    13 embryo 14-16hr    15 embryo 16-18hr    16 embryo 18-20hr    17 embryo 20-22hr    21 embryo 22-24hr    24 larva L1    9 larva L2    10 larva L3 12hr old    8 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    15 white prepupae new    15 white prepupae 12hr    11 white prepupae 24hr    11 pupae 2d postWPP    9 pupae 3d postWPP    7 pupae 4d postWPP    7 adult male 01day    7 adult male 05day    7 adult male 30day    7 adult female 01day    10 adult female 05day    16 adult female 30day    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    28 embryo 02-04hr    35 embryo 04-06hr    32 embryo 06-08hr    15 embryo 08-10hr    16 embryo 10-12hr    15 embryo 12-14hr    13 embryo 14-16hr    15 embryo 16-18hr    16 embryo 18-20hr    17 embryo 20-22hr    21 embryo 22-24hr    24 larva L1    9 larva L2    10 larva L3 12hr old    8 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    15 white prepupae new    15 white prepupae 12hr    11 white prepupae 24hr    11 pupae 2d postWPP    9 pupae 3d postWPP    7 pupae 4d postWPP    7 adult male 01day    7 adult male 05day    7 adult male 30day    7 adult female 01day    10 adult female 05day    16 adult female 30day    17 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    28 embryo 02-04hr    35 embryo 04-06hr    32 embryo 06-08hr    15 embryo 08-10hr    16 embryo 10-12hr    15 embryo 12-14hr    13 embryo 14-16hr    15 embryo 16-18hr    16 embryo 18-20hr    17 embryo 20-22hr    21 embryo 22-24hr    24 larva L1    9 larva L2    10 larva L3 12hr old    8 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    15 white prepupae new    15 white prepupae 12hr    11 white prepupae 24hr    11 pupae 2d postWPP    9 pupae 3d postWPP    7 pupae 4d postWPP    7 adult male 01day    7 adult male 05day    7 adult male 30day    7 adult female 01day    10 adult female 05day    16 adult female 30day    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  28 embryo 02-04hr  (35) embryo 04-06hr  32 embryo 06-08hr    15 embryo 08-10hr    16 embryo 10-12hr    15 embryo 12-14hr    13 embryo 14-16hr    15 embryo 16-18hr    16 embryo 18-20hr    17 embryo 20-22hr    21 embryo 22-24hr    24 larva L1    9 larva L2    10 larva L3 12hr old    8 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    15 white prepupae new    15 white prepupae 12hr    11 white prepupae 24hr    11 pupae 2d postWPP    9 pupae 3d postWPP    7 pupae 4d postWPP    7 adult male 01day    7 adult male 05day    7 adult male 30day    7 adult female 01day    10 adult female 05day    16 adult female 30day    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    28 embryo 02-04hr    35 embryo 04-06hr    32 embryo 06-08hr    15 embryo 08-10hr    16 embryo 10-12hr    15 embryo 12-14hr    13 embryo 14-16hr    15 embryo 16-18hr    16 embryo 18-20hr    17 embryo 20-22hr    21 embryo 22-24hr    24 larva L1    9 larva L2    10 larva L3 12hr old    8 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    15 white prepupae new    15 white prepupae 12hr    11 white prepupae 24hr    11 pupae 2d postWPP    9 pupae 3d postWPP    7 pupae 4d postWPP    7 adult male 01day    7 adult male 05day    7 adult male 30day    7 adult female 01day    10 adult female 05day    16 adult female 30day    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    28 embryo 02-04hr    35 embryo 04-06hr    32 embryo 06-08hr    15 embryo 08-10hr    16 embryo 10-12hr    15 embryo 12-14hr    13 embryo 14-16hr    15 embryo 16-18hr    16 embryo 18-20hr    17 embryo 20-22hr    21 embryo 22-24hr    24 larva L1    9 larva L2    10 larva L3 12hr old    8 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    15 white prepupae new    15 white prepupae 12hr    11 white prepupae 24hr    11 pupae 2d postWPP    9 pupae 3d postWPP    7 pupae 4d postWPP    7 adult male 01day    7 adult male 05day    7 adult male 30day    7 adult female 01day    10 adult female 05day    16 adult female 30day    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    26 Schneider line 2 Sg4    9 embryonic 1182-4H    15 embryonic GM2    15 embryonic Kc167    10 embryonic S1    13 embryonic S3    10 leg disc CME L1    9 wing disc CME-W2    13 wing disc ML-DmD8    14 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    9 wing disc ML-DmD21    9 wing disc ML-DmD32    9 haltere disc ML-DmD17-c3    21 eye-antennal disc ML-DmD11    14 antennal disc ML-DmD20-c5    22 mixed discs ML-DmD4-c1    15 CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    28 ovary fGS/OSS    7 ovary OSC    5 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  26 Schneider line 2 Sg4    9 embryonic 1182-4H    15 embryonic GM2    15 embryonic Kc167    10 embryonic S1    13 embryonic S3    10 leg disc CME L1    9 wing disc CME-W2    13 wing disc ML-DmD8    14 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    9 wing disc ML-DmD21    9 wing disc ML-DmD32    9 haltere disc ML-DmD17-c3    21 eye-antennal disc ML-DmD11    14 antennal disc ML-DmD20-c5    22 mixed discs ML-DmD4-c1    15 CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2  (28) ovary fGS/OSS    7 ovary OSC    5 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    26 Schneider line 2 Sg4    9 embryonic 1182-4H    15 embryonic GM2    15 embryonic Kc167    10 embryonic S1    13 embryonic S3    10 leg disc CME L1    9 wing disc CME-W2    13 wing disc ML-DmD8    14 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    9 wing disc ML-DmD21    9 wing disc ML-DmD32    9 haltere disc ML-DmD17-c3    21 eye-antennal disc ML-DmD11    14 antennal disc ML-DmD20-c5    22 mixed discs ML-DmD4-c1    15 CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    28 ovary fGS/OSS    7 ovary OSC    5 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    26 Schneider line 2 Sg4    9 embryonic 1182-4H    15 embryonic GM2    15 embryonic Kc167    10 embryonic S1    13 embryonic S3    10 leg disc CME L1    9 wing disc CME-W2    13 wing disc ML-DmD8    14 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    9 wing disc ML-DmD21    9 wing disc ML-DmD32    9 haltere disc ML-DmD17-c3    21 eye-antennal disc ML-DmD11    14 antennal disc ML-DmD20-c5    22 mixed discs ML-DmD4-c1    15 CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    28 ovary fGS/OSS    7 ovary OSC    5 ovary OSS    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    26 Schneider line 2 Sg4    9 embryonic 1182-4H    15 embryonic GM2    15 embryonic Kc167    10 embryonic S1    13 embryonic S3    10 leg disc CME L1    9 wing disc CME-W2    13 wing disc ML-DmD8    14 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    9 wing disc ML-DmD21    9 wing disc ML-DmD32    9 haltere disc ML-DmD17-c3    21 eye-antennal disc ML-DmD11    14 antennal disc ML-DmD20-c5    22 mixed discs ML-DmD4-c1    15 CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    28 ovary fGS/OSS    7 ovary OSC    5 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  26 Schneider line 2 Sg4    9 embryonic 1182-4H    15 embryonic GM2    15 embryonic Kc167    10 embryonic S1    13 embryonic S3    10 leg disc CME L1    9 wing disc CME-W2    13 wing disc ML-DmD8    14 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    9 wing disc ML-DmD21    9 wing disc ML-DmD32    9 haltere disc ML-DmD17-c3    21 eye-antennal disc ML-DmD11    14 antennal disc ML-DmD20-c5    22 mixed discs ML-DmD4-c1    15 CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2  28 ovary fGS/OSS    7 ovary OSC    5 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    26 Schneider line 2 Sg4    9 embryonic 1182-4H    15 embryonic GM2    15 embryonic Kc167    10 embryonic S1    13 embryonic S3    10 leg disc CME L1    9 wing disc CME-W2    13 wing disc ML-DmD8    14 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    9 wing disc ML-DmD21    9 wing disc ML-DmD32    9 haltere disc ML-DmD17-c3    21 eye-antennal disc ML-DmD11    14 antennal disc ML-DmD20-c5    22 mixed discs ML-DmD4-c1    15 CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    28 ovary fGS/OSS    7 ovary OSC    5 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    26 Schneider line 2 Sg4    9 embryonic 1182-4H    15 embryonic GM2    15 embryonic Kc167    10 embryonic S1    13 embryonic S3    10 leg disc CME L1    9 wing disc CME-W2    13 wing disc ML-DmD8    14 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    9 wing disc ML-DmD21    9 wing disc ML-DmD32    9 haltere disc ML-DmD17-c3    21 eye-antennal disc ML-DmD11    14 antennal disc ML-DmD20-c5    22 mixed discs ML-DmD4-c1    15 CNS ML-DmBG1-c1    11 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    28 ovary fGS/OSS    7 ovary OSC    5 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    8 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    7 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    6 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    8 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    7 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    6 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    8 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    7 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    6 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    8 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    7 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    6 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    8 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    7 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    6 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    8 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    7 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    6 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    8 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    7 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    6 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    8 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    7 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    6 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_05 mE1_20_mRNA_expression_cluster_04
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0026378 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8432-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | pupal stage, with Scer\GAL4pnr-MD237 RepGD13780 Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of Rep Class Mutagen Stocks Known lesion Repf01510 piggyBac transposase 3 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Rep Class Mutagen Stocks Known lesion RepGD13780 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes RepJF02882 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes RepNIG.8432R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD13780} NA P{NIG.8432R} NA P{TRiP.JF02882} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{WH}Repf01510 NA
Gene Ontology: Function, Process & Cellular Component ( 11 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function ( 0 terms)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
aster inferred from direct assay (assigned by UniProtKB) (Dong et al., 1999) perinuclear region of cytoplasm inferred from direct assay (assigned by UniProtKB) (Dong et al., 1999) spindle pole inferred from direct assay (assigned by UniProtKB) (Dong et al., 1999)
Terms Based on Predictions or Assertions ( 8 terms )
Molecular Function
CV term Evidence References
contributes_to Rab geranylgeranyltransferase activity inferred from sequence or structural similarity with UniProtKB:P37727 (FlyBase, 1992-) Rab GTPase binding inferred from sequence or structural similarity with UniProtKB:P37727 (FlyBase, 1992-) non-traceable author statement (Dong, 1998.11.7)
Biological Process
CV term Evidence References
neurotransmitter secretion non-traceable author statement (Lloyd et al., 2000) vesicle-mediated transport non-traceable author statement (Lloyd et al., 2000)
Cellular Component
CV term Evidence References
cytoplasm inferred from sequence or structural similarity with UniProtKB:P32864 (assigned by UniProtKB) (Dong et al., 1999) membrane inferred from sequence or structural similarity with UniProtKB:P32864 (assigned by UniProtKB) (Dong et al., 1999) Rab-protein geranylgeranyltransferase complex inferred from sequence or structural similarity with UniProtKB:P37727 (FlyBase, 1992-) synaptic vesicle non-traceable author statement (Lloyd et al., 2000)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Rep allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 62904 DroID - A comprehensive database of gene and protein interactions. • FBgn0026378 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37246
Orthologs
OrthoDB Orthologs (41) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG60CJ2V Dipteran inclusive ortholog search EOG64TPHD Insect inclusive ortholog search EOG64XHC8 Arthropod inclusive ortholog search EOG68KPSN Metazoa inclusive ortholog search EOG6Z6FG2
Orthologs in Drosophila Species (EOG60CJ2V)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Rep     Drosophila simulans   Dsim\GD11461 Y   Drosophila sechellia   Dsec\GM21968 Y   Drosophila erecta   Dere\GG21980 Y   Drosophila yakuba   Dyak\GE12059 Y   Drosophila ananassae   Dana\GF11718 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA21074 Y   Drosophila persimilis   Dper\GL11541 Y   Drosophila willistoni   Dwil\GK15875 Y   Drosophila virilis   Dvir\GJ20912 Y   Drosophila mojavensis   Dmoj\GI18968 Y   Drosophila grimshawi   Dgri\GH23002 Y
Orthologs in non-Drosophila Dipterans (EOG64TPHD)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL004329   Anopheles gambiae Malaria mosquito  Agam\AGAP010419   Anopheles gambiae Malaria mosquito  Agam\AGAP012773   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ010669
Orthologs in non-Dipteran Insects (EOG64XHC8)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB42516   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG009088   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH16350   Atta cephalotes Leafcutter ant  Acep\ACEP20197   Camponotus floridanus Florida carpenter ant  Cflo\CFLO21693   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL18728   Linepithema humile Argentine ant  Lhum\LH18594   Pogonomyrmex barbatus Red harvester ant  Pbar\PB12354   Solenopsis invicta Red fire ant  Sinv\SINV23384   Acyrthosiphon pisum Pea aphid  Apim\ACYPI009536   Bombyx mori Silkmoth  Bmor\BGIBMGA001126   Pediculus humanus Human body louse  Phum\PHUM432580   Tribolium castaneum Red flour beetle  Tcas\GLEAN_07846
Orthologs in non-Insect Arthropods (EOG68KPSN)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_329332   Ixodes scapularis Deer tick  Isca\ISCW023023
Orthologs in non-Arthropod Metazoa (EOG6Z6FG2)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\rep-1   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_013346gn   Danio rerio Zebrafish  Drer\chm   Xenopus tropicalis Western clawed frog  Xtro\chm   Gallus gallus Domestic chicken  Ggal\CHML   Mus musculus House mouse  Mmus\ENSMUSG00000078185   Mus musculus House mouse  Mmus\Chm   Rattus norvegicus Norway rat  Rnor\Chm   Homo sapiens Human  Hsap\CHM   Homo sapiens Human  Hsap\CHML
Human Orthologs (2)
Gene OMIM HGNC Hsap\CHM     Hsap\CHML
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD11461 Drosophila sechellia Dsec\GM21968 Drosophila erecta Dere\GG21980 Drosophila yakuba Dyak\GE12059 Drosophila ananassae Dana\GF11718 Drosophila pseudoobscura pseudoobscura Dpse\GA21074 Drosophila persimilis Dper\GL11541 Drosophila willistoni Dwil\GK15875 Drosophila virilis Dvir\GJ20912 Drosophila mojavensis Dmoj\GI18968 Drosophila grimshawi Dgri\GH23002
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	28047 y1 v1; P{TRiP.JF02882}attP2 18445 w1118; PBac{WH}Repf01510/CyO
Harvard	- PBac{WH}Repf01510
Kyoto	114525 yd2 w1118 P{ey-FLP.N}2; P{neoFRT}42D PBac{WH}Repf01510 /CyO y+
VDRC	v28866 w1118; P{GD13780}v28866 v28864 w1118; P{GD13780}v28864/TM3
Genomic Clones ( 2 )
	BACR25K02 BACR26L01 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 23 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD02194
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH24791 LD01134 LD09431 LD22257 LD37092 RE24025 RE64736 RE66671 RE69643 RE72758
Other clones	39573 77358 277087 569040 CK01.66C.H4 CK01.120C.D8 EK045603 EK092009 EK092034 EK236157 EK304212 EP18901
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0026378 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37246
Antibody Information
	polyclonal (Dong et al., 1999)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Rep CG8432 (Milshina, 1999.11)
Source for database merge of
Additional comments
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_058072 RefSeq (Proteins) • NP_477420 DDBJ / EMBL / GenBank • AA202509 AAD16891 AAF57544 AAL28600 AC004311 AF105063 AW941494 AY061052 CZ483981 Entrez Gene - A searchable database of RefSeq genes. • 37246 UniProtKB/Swiss-Prot • Q9V8W3
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • GDP dissociation inhibitor (IPR018203) Rab protein geranylgeranyltransferase component A, eukaryota (IPR016664)
Linkouts
	BioGRID - A database of protein and genetic interactions • 62904 DroID - A comprehensive database of gene and protein interactions. • FBgn0026378 DRSC - Results from RNAi screens. • FBgn0026378 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0026378 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8432-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0026378 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37246 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37246 modMine - Data generated by the modENCODE project. • FBgn0026378
Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	CG8432 (Pile et al., 2003, Sinka et al., 2008, Perkins et al., 2009) REP (Dong et al., 1999) Rep (Sinka et al., 2008, Buffin and Gho, 2010, Japanese National Institute of Genetics, 2012.5.21)
Name Synonym	rab escort protein (Lloyd et al., 2000) Rab escort protein (Buffin and Gho, 2010) Rab escort protein homolog (Dong, 1998.11.7)
Secondary FlyBase IDs
References ( 26 )
Generate a list of	All references relating to this gene ( 26 )
List References by type	Research paper  ( 5 ) Supplementary material  ( 6 ) Personal communication to FlyBase  ( 7 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 1 ) Stock list  ( 1 ) Curated genome annotation  ( 3 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2011 Show research papers ...