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General Information
Symbol
Dmel\Pten
Species
D. melanogaster
Name
Phosphatase and tensin homolog
Annotation Symbol
CG5671
Feature Type
FlyBase ID
FBgn0026379
Gene Model Status
Stock Availability
Enzyme Name (EC)
Protein-serine/threonine phosphatase (3.1.3.16)
Protein-tyrosine-phosphatase (3.1.3.48)
Phosphatidylinositol-3-phosphatase (3.1.3.64)
Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase (3.1.3.67)
Gene Snapshot
Phosphatase and tensin homolog (Pten) encodes a dual lipid and protein phosphatase that primarily counters the effects of the insulin-regulated lipid kinase, encoded by Pi3K92E. It inhibits cell growth, cell proliferation and cellular events controlling cytoskeletal and junctional rearrangements. [Date last reviewed: 2018-10-18]
Also Known As
dPTEN
Key Links
Genomic Location
Cytogenetic map
Sequence location
2L:10,256,319..10,261,049 [-]
Recombination map
2-40
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Protein Family (UniProt)
-
Catalytic Activity (EC)
Experimental Evidence
[a protein]-serine/threonine phosphate + H(2)O = [a protein]- serine/threonine + phosphate (3.1.3.16)
Phosphatidylinositol 3,4,5-trisphosphate + H(2)O = phosphatidylinositol 4,5-bisphosphate + phosphate (3.1.3.67)
Predictions / Assertions
[a protein]-serine/threonine phosphate + H(2)O = [a protein]- serine/threonine + phosphate (3.1.3.16)
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate (3.1.3.48)
1-phosphatidyl-1D-myo-inositol 3-phosphate + H(2)O = 1-phosphatidyl- 1D-myo-inositol + phosphate (3.1.3.64)
Phosphatidylinositol 3,4,5-trisphosphate + H(2)O = phosphatidylinositol 4,5-bisphosphate + phosphate (3.1.3.67)
Summaries
Gene Group (FlyBase)
DUAL SPECIFICITY PHOSPHATASES -
Dual Specificity Phosphatases (DSP) can dephosphorylate both tyrosine and serine/threonine residues. Additionally, DSPs may target a much larger and diverse set of substrates, including phosphoinositide lipids, RNA 5'-triphosphate and carbohydrates. (Adapted from FBrf0227974).
PHOSPHATIDYLINOSITOL PHOSPHATE AND INOSITOL PHOSPHATE PHOSPHATASES -
Phosphoinositide phosphate (PtdInsP) phosphatases and Inositol phosphate (InsP) phosphatases are enzymes that catalyze the hydrolysis of phosphate groups from inositol. Many of these phosphatases can act on both PtdInsP and InsP substrates. (Adapted from PMID:23681533).
Pathway (FlyBase)
Negative Regulators of Insulin-like Receptor Signaling Pathway -
Negative regulators of the Insulin-like Receptor signaling pathway suppress Insulin-like receptor (InR) activation or the activity of intracellular effectors. (Adapted from FBrf0232297, FBrf0230017 and FBrf0229989).
Summary (Interactive Fly)
lipid and protein phosphatase acting in insulin pathway - PTEN, a tumour suppressor, is a lipid and protein phosphatase that inhibits phosphoinositide 3-kinase (PI3K)-dependent signalling by dephosphorylating phosphatidylinositol 3,4,5-trisphosphate
Gene Model and Products
Number of Transcripts
7
Number of Unique Polypeptides
3

Please see the GBrowse view of Dmel\Pten or the JBrowse view of Dmel\Pten for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Alternative translation stop created by use of multiphasic reading frames within coding region.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.46
Low-frequency RNA-Seq exon junction(s) not annotated (in 3' UTR).
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0089905
2568
509
FBtr0089904
2355
514
FBtr0089902
1803
418
FBtr0089900
2125
514
FBtr0089901
2338
509
FBtr0300562
2617
514
FBtr0301521
2467
514
Additional Transcript Data and Comments
Reported size (kB)
1.872 (longest cDNA)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0088844
58.4
509
7.25
FBpp0088843
59.0
514
7.25
FBpp0088841
48.1
418
7.23
FBpp0088839
59.0
514
7.25
FBpp0088840
58.4
509
7.25
FBpp0289789
59.0
514
7.25
FBpp0290736
59.0
514
7.25
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

514 aa isoforms: Pten-PB, Pten-PD, Pten-PG, Pten-PH
509 aa isoforms: Pten-PA, Pten-PE
Additional Polypeptide Data and Comments
Reported size (kDa)
514, 509 (aa)
511, 509, 418 (aa)
Comments
External Data
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Pten using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (66 terms)
Molecular Function (9 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (9 terms)
CV Term
Evidence
References
inferred from sequence or structural similarity with UniProtKB:P60484
(assigned by UniProt )
inferred from sequence or structural similarity with UniProtKB:P60484
(assigned by UniProt )
inferred from sequence or structural similarity with UniProtKB:P60484
(assigned by UniProt )
inferred from sequence or structural similarity with UniProtKB:P60484
(assigned by UniProt )
inferred from sequence or structural similarity with HGNC:9588
inferred from sequence or structural similarity with UniProtKB:P60484
(assigned by UniProt )
inferred from sequence or structural similarity with UniProtKB:P60484
(assigned by UniProt )
inferred from electronic annotation with InterPro:IPR000340
(assigned by InterPro )
Biological Process (55 terms)
Terms Based on Experimental Evidence (49 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:Atg18a; FB:FBgn0035850
inferred from genetic interaction with FLYBASE:Atg1; FB:FBgn0260945
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:Pi3K92E; FB:FBgn0015279
inferred from genetic interaction with FLYBASE:chico; FB:FBgn0024248
inferred from genetic interaction with FLYBASE:InR; FB:FBgn0283499
inferred from mutant phenotype
inferred from mutant phenotype
(assigned by UniProt )
inferred from mutant phenotype
inferred from genetic interaction with UniProtKB:Q8INB9
(assigned by UniProt )
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
(assigned by UniProt )
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
Terms Based on Predictions or Assertions (11 terms)
CV Term
Evidence
References
inferred from sequence or structural similarity with UniProtKB:P60484
(assigned by UniProt )
inferred from sequence or structural similarity with UniProtKB:P60484
(assigned by UniProt )
inferred from sequence or structural similarity with UniProtKB:P60484
(assigned by UniProt )
inferred from sequence or structural similarity with UniProtKB:P60484
(assigned by UniProt )
inferred from sequence or structural similarity with UniProtKB:P60484
(assigned by UniProt )
inferred from electronic annotation with InterPro:IPR017361
(assigned by InterPro )
non-traceable author statement
inferred from sequence or structural similarity with HGNC:9588
inferred from sequence or structural similarity with UniProtKB:P60484
(assigned by UniProt )
inferred from sequence or structural similarity with UniProtKB:P60484
(assigned by UniProt )
Cellular Component (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
inferred from sequence or structural similarity with HGNC:9588
inferred from sequence or structural similarity with HGNC:9588
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
organism

Comment: maternally deposited

Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Pten in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 15 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 25 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Pten
Transgenic constructs containing regulatory region of Pten
Deletions and Duplications ( 5 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
lipid droplet & larval oenocyte, with Scer\GAL4ppl.PP
lipid particle & nurse cell | somatic clone
nurse cell & actin cytoskeleton | germ-line clone
nurse cell & nucleus | germ-line clone
wing & cell | somatic clone
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (9)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
13 of 15
Yes
Yes
 
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
1 of 15
No
No
1 of 15
No
No
 
1 of 15
No
No
 
1 of 15
No
Yes
1 of 15
Yes
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (8)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
13 of 15
Yes
Yes
2 of 15
No
No
2 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (6)
10 of 13
Yes
Yes
2 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
Yes
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (7)
11 of 12
Yes
Yes
2 of 12
No
Yes
2 of 12
No
Yes
1 of 12
No
No
1 of 12
No
No
1 of 12
No
Yes
1 of 12
No
Yes
Danio rerio (Zebrafish) (13)
13 of 15
Yes
Yes
8 of 15
No
Yes
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (2)
9 of 15
Yes
Yes
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (3)
3 of 9
Yes
Yes
3 of 9
Yes
Yes
2 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (2)
7 of 15
Yes
Yes
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (2)
4 of 12
Yes
Yes
1 of 12
No
No
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG0919062I )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091506HB )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W06JY )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X06FR )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G09VG )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (2)
2 of 10
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Potential Models Based on Orthology ( 3 )
Modifiers Based on Experimental Evidence ( 1 )
Allele
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Interactions
Summary of Physical Interactions
esyN Network Diagram
Show neighbor-neighbor interactions:
Select Layout:
Legend:
Protein
RNA
Selected Interactor(s)
Interactions Browser

Please see the Physical Interaction reports below for full details
protein-protein
Physical Interaction
Assay
References
Summary of Genetic Interactions
esyN Network Diagram
esyN Network Key:
Suppression
Enhancement

Please look at the allele data for full details of the genetic interactions
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
External Data
Linkouts
BioGRID - A database of protein and genetic interactions.
DroID - A comprehensive database of gene and protein interactions.
InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
Pathways
Genomic Location and Detailed Mapping Data
Chromosome (arm)
2L
Recombination map
2-40
Cytogenetic map
Sequence location
2L:10,256,319..10,261,049 [-]
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
31B1-31B1
Limits computationally determined from genome sequence between P{lacW}me31Bk06607 and P{PZ}nmd08774
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
31A1-31D6
31B-31C
(determined by in situ hybridisation)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Stocks and Reagents
Stocks (16)
Genomic Clones (26)
cDNA Clones (30)
 

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequences
BDGP DGC clones
Other clones
Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
RNAi and Array Information
Linkouts
DRSC - Results frm RNAi screens
GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
Antibody Information
Laboratory Generated Antibodies
Commercially Available Antibodies
 
Other Information
Relationship to Other Genes
Source for database identify of
Source for database merge of
Source for merge of: Pten CG5671
Additional comments
Other Comments
dsRNA has been made from templates generated with primers directed against this gene.
dsRNA made from templates generated with primers directed against this gene results in an increase in mean cell diameter.
dsRNA made from templates generated with primers directed against this gene used to treat S2 cells.
dsRNA made from templates generated with primers directed against this gene increase the levels of phosphorylation of boh Akt1 and S6k in S2 cells.
One of 42 Drosophila genes identified as being most likely to reveal molecular and cellular mechanisms of nervous system development or plasticity relevant to human Mental Retardation disorders.
PI3K activity is regulated through EcR signalling in a cell-autonomous manner to allow programmed autophagy in the fat body.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167 cells: change from round to spindle-shaped, with the formation of F-actin puncta and microtubule extensions. Alterations of cell shape are also evident in S2R+ cells - they become round and detached. The Kc167 cell-shape change is suppressed by simultaneous treatment with dsRNA targetted against Akt1, CG31187, LIMK1, MAPk-Ak2, Pi3K92E, slpr or wee.
Pten plays an essential role in the control of, cell size, cell number, and organ size.
Pten acts antagonistically to Pi3K92E and chico. In direction of increasing cytology: chico- bsk- Ror+ Pten-
Pten has a complex role in regulating tissue and body size. Pten regulates the subcellular organization of the actin cytoskeleton in multiple cell types.
Both inactivation and overexpression of Pten affect cell size, and overexpression of Pten inhibits cell cycle progression at early mitosis and promotes cell death during eye development. Phenotypes caused by overexpression of Hsap\PTEN and Pten are indistinguishable.
The phosphatase activity of Pten is necessary for it to exert its functions during development. In direction of increasing cytology: Rsf1+ Pten+ CG5676+ Ror- bsk+ chico+
Pten acts in the insulin signalling pathway. All signals from the InR protein can be antagonized by Pten.
Pten regulates cell size and cell proliferation via the actin cytoskeleton.
Origin and Etymology
Discoverer
Etymology
Identification
External Crossreferences and Linkouts ( 104 )
Sequence Crossreferences
NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
Other crossreferences
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
KEGG Genes - Molecular building blocks of life in the genomic space.
KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
modMine - A data warehouse for the modENCODE project
SignaLink - A signaling pathway resource with multi-layered regulatory networks.
Linkouts
BioGRID - A database of protein and genetic interactions.
DPiM - Drosophila Protein interaction map
DroID - A comprehensive database of gene and protein interactions.
DRSC - Results frm RNAi screens
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyMine - An integrated database for Drosophila genomics
Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
Synonyms and Secondary IDs (17)
Reported As
Symbol Synonym
PTEN
(Galenza and Foley, 2019, Hwang et al., 2019, Mondin et al., 2019, Rosen et al., 2019, Ghiglione et al., 2018, Gruntenko and Rauschenbach, 2018, Inoue et al., 2018, Parvy et al., 2018, Pichaud, 2018, Poon et al., 2018, Richardson and Portela, 2018, Spéder and Brand, 2018, Swevers et al., 2018, Brace and DiAntonio, 2017, Moeller et al., 2017, Murillo-Maldonado and Riesgo-Escovar, 2017, Paglia et al., 2017, Romero-Pozuelo et al., 2017, Cheng et al., 2016, Kaynar et al., 2016, Marmor-Kollet and Schuldiner, 2016, Yadav et al., 2016, Aradhya et al., 2015, Bennett et al., 2015, Nässel et al., 2015, Devergne et al., 2014, Oliveira et al., 2014, Pichaud, 2014, Radermacher et al., 2014, Wang et al., 2014, Andersen et al., 2013, Chen and Zhang, 2013, Hwang et al., 2013, Koyama et al., 2013, Nowak et al., 2013, Okamoto et al., 2013, Oortveld et al., 2013, Shim et al., 2013, Sim and Denlinger, 2013, Tran et al., 2013, Wong et al., 2013, Yin et al., 2013, Chountala et al., 2012, Dahlgaard et al., 2012, Denton et al., 2012, Eleftherianos and Castillo, 2012, Gault et al., 2012, Lv et al., 2012, Tepass, 2012, Bangi et al., 2011, Friedman et al., 2011, Laprise and Tepass, 2011, Miles et al., 2011, Oldham, 2011, Park et al., 2011, Partridge et al., 2011, Poon et al., 2011, Read, 2011, Resnik-Docampo and de Celis, 2011, Tang et al., 2011, Yang and Xu, 2011, Delanoue et al., 2010, Lee et al., 2010, Mesquita et al., 2010, Montagne et al., 2010, Tsuda et al., 2010, Tsuda et al., 2010, Géminard et al., 2009, Ikeya et al., 2009, Ninov et al., 2009, Nuzhdin et al., 2009, Read et al., 2009, Shelly et al., 2009, Werz et al., 2009, Bakal et al., 2008, Honegger et al., 2008, Howlett et al., 2008, Lee et al., 2008, Mattila et al., 2008, Rafel and Milán, 2008, Seisenbacher et al., 2008, Vereshchagina et al., 2008, Basu and Krek, 2007, Bergman et al., 2007, Cortina-Andrada et al., 2007, Gutierrez et al., 2007, Hall et al., 2007, Hietakangas and Cohen, 2007, Hoshizaki and Gibbs, 2007, Jovceva et al., 2007, Juhász et al., 2007, Libert, 2007, Palmer and Pichaud, 2007, Tyler et al., 2007, Wilson et al., 2007, Betschinger et al., 2006, Edgar, 2006, Edgar, 2006, Fehon, 2006, Frias et al., 2006, Frias et al., 2006, Guertin et al., 2006, Lindmo et al., 2006, Pinal et al., 2006, Shiojima and Walsh, 2006, Vereshchagina and Wilson, 2006, Cygnar et al., 2005, McNeill and Bateman, 2005, Mikeladze-Dvali et al., 2005, Mirth et al., 2005, Shingleton, 2005, Bilder, 2004, Clague et al., 2004, Pan et al., 2004, Scott et al., 2004, Scott et al., 2004, von Stein et al., 2004, Hardie, 2003, von Stein et al., 2003, Gao et al., 2002, Neufeld, 2001.1.11, Oldham et al., 2001, Potter et al., 2000, Scanga et al., 2000, Weinkove and Leevers, 2000, Wilson et al., 2000, Smith, 1999.6.23, Smith, 1999.6.23, Smith, 1999.6.23)
Pten
(Birnbaum et al., 2019, Brodskiy et al., 2019, Hwang et al., 2019, Zheng, 2019.3.1, Ayala et al., 2018, Kang et al., 2018, Nowak et al., 2018, Tang et al., 2018, Villegas et al., 2018, Viswanatha et al., 2018, Wang et al., 2018, Fedina et al., 2017, Hevia et al., 2017, Mensah et al., 2017, Song et al., 2017, Transgenic RNAi Project members, 2017-, Di Cara and King-Jones, 2016, Padash Barmchi et al., 2016, Schmid et al., 2016, Vinayagam et al., 2016, Xu et al., 2016, Grotewiel and Bettinger, 2015, Hatzihristidis et al., 2015, Jia et al., 2015, Kwon et al., 2015, Mensah et al., 2015, Park et al., 2015, Song et al., 2015, Sopko et al., 2015, Tokusumi et al., 2015, Das et al., 2014, Khadilkar et al., 2014, Sato-Miyata et al., 2014, Sopko et al., 2014, Wang et al., 2014, Carter, 2013, Dobens and Dobens, 2013, Heigwer et al., 2013, Pickering et al., 2013, Pomerantz and Blau, 2013, Rousso et al., 2013, Schertel et al., 2013, Sopko and Perrimon, 2013, Tixier et al., 2013, Tixier et al., 2013, Howell et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Justiniano et al., 2012, Kuo et al., 2012, Marinari et al., 2012, Papatheodorou et al., 2012, Pircs et al., 2012, Song et al., 2012, Tokusumi et al., 2012, Zhai et al., 2012, Djiane et al., 2011, Eddison et al., 2011, Lindquist et al., 2011, Sousa-Nunes et al., 2011, Willecke et al., 2011, Demontis and Perrimon, 2010, Haberman et al., 2010, Kim et al., 2010, Lee et al., 2010, Nedelsky et al., 2010, Sinenko et al., 2010, Zheng and Sehgal, 2010, Alvarez-Ponce et al., 2009, Demontis and Perrimon, 2009, Doumanis et al., 2009, Mirth et al., 2009, Mummery-Widmer et al., 2009, Parrish et al., 2009, Qian and Bodmer, 2009, Rhiner et al., 2009, Sims et al., 2009, Hou et al., 2008, Yin et al., 2008, Zhou et al., 2008, Chen et al., 2007, Ford et al., 2007, Knox et al., 2007, Friedman and Perrimon, 2006, Wiggin et al., 2005, Bruckner et al., 2004, Wheeler et al., 2004)
Name Synonyms
Drosophila phosphatase and tensin homologue deleted on chromosome 10
PI 3-phosphatase
Phosphatase and tensin homolog
Phosphatase and tensin homologue
PtdIns(3,4,5)P3 phosphatase
phosphatase and tensin homolog
phosphatidylinositol (3,4,5)-trisphosphate phosphatase
Secondary FlyBase IDs
  • FBgn0032201
Datasets (0)
Study focus (0)
Experimental Role
Project
Project Type
Title
References (433)