• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • RNA-Seq Search
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • GBrowse 2 Beta
    • CytoSearch
    • Feature Mapper
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Current release
  • Archived releases
  • Map Conversion
  • FTP site:
  • Releases (FTP)
  • Genomes (FTP)
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Vectors & Constructs
  • Other links:
  • BDGP
  • DGRC
  • DIS by issue
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\Pten

General Information
Symbol	Dmel\Pten	Species	D. melanogaster
Name	Pten	Annotation symbol	CG5671
Feature type	protein_coding_gene	FlyBase ID	FBgn0026379
Gene Model Status	Current	Stock availability	10 publicly available
Also Known As	dPTEN
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	31B1-31B1	Sequence location	2L:10,256,319..10,261,049 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Pten is referred to in FlyBase by the symbol Dmel\Pten (CG5671, FBgn0026379). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: phosphoprotein phosphatase activity; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity; protein serine/threonine phosphatase activity. There is experimental evidence for 31 unique biological process terms, many of which group under: biological regulation; cellular component organization or biogenesis; regulation of developmental process; single-organism developmental process; organelle organization; regulation of neurogenesis; actin filament-based process; cell proliferation; immune response; macromolecule modification; programmed cell death; localization; response to nutrient levels; gland morphogenesis; open tracheal system development; catabolic process. 42 alleles are reported. The phenotypes of these alleles are annotated with: organ system; organ system subdivision; external compound sense organ; adult segment; thoracic segment; peripheral nervous system; adult; imaginal precursor; multicellular structure; embryonic/larval corpus allatum; embryonic/larval fat body; cell part; cell cycle. It has 7 annotated transcripts and 7 annotated polypeptides. Protein features are: Bifunctional phosphatidylinositol trisphosphate phosphatase/dual specificity phosphatase PTEN; C2 calcium/lipid-binding domain, CaLB; Dual specificity phosphatase, catalytic domain; Phosphatase tensin type; Protein-tyrosine phosphatase, active site; Tensin phosphatase, C2 domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of low expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult crop, larval salivary gland, adult female reproductive system, adult testis. Gene sequence location is 2L:10256319..10261049.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 31B1-31B1   Limits computationally determined from genome sequence between P{lacW}me31Bk06607 and P{PZ}nmd08774
Experimentally Determined Cytological Location
Cytogenetic map Notes References 31B-31C     (Goberdhan, 1999.11.4) 31C-31D     (Tao, 1999.4.19) 31A1-31D6     (Smith, 1999.6.23) 31B-31C   (determined by in situ hybridisation)   (Wilson, 1999.3.4)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Pten for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Alternative translation stop created by use of multiphasic reading frames within coding region. Gene model reviewed during 5.46 Annotated transcripts do not represent all supported alternative splices within 5' UTR and 3' UTR.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Pten-RA FBtr0089905  NM_134320   2568   509 Pten-RB FBtr0089904  NM_058075   2355   514 Pten-RC FBtr0089902  NM_058076   1803   418 Pten-RD FBtr0089900  NM_134322   2125   514 Pten-RE FBtr0089901  NM_134321   2338   509 Pten-RG FBtr0300562  NM_001169462   2617   514 Pten-RH FBtr0301521  NM_058074   2467   514
Additional Transcript Data & Comments
Reported size (kB)	1.872 (longest cDNA) (Huang et al., 1999)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Pten-PA   FBpp0088844   58.4   509   7.25     NP_599147   AAF52887 Pten-PB   FBpp0088843   59.0   514   7.25     NP_477423   AAN10731 Pten-PC   FBpp0088841   48.1   418   7.23     NP_477424   AAN10730 Pten-PD   FBpp0088839   59.0   514   7.25     NP_599149   AAF52888 Pten-PE   FBpp0088840   58.4   509   7.25     NP_599148   AAF52889 Pten-PG   FBpp0289789   59.0   514   7.25     NP_001162933   ACZ94222 Pten-PH   FBpp0290736   59.0   514   7.25     NP_477422   AAN10732
Additional Polypeptide Data & Comments
Reported size (kDa)	514 (aa) (Huang et al., 1999) 514, 509 (aa) (Goberdhan et al., 1999) 511, 509, 418 (aa) (Smith et al., 1999)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Dual specificity phosphatase, catalytic domain (IPR000340) C2 calcium/lipid-binding domain, CaLB (IPR008973) Phosphatase tensin type (IPR014019) Tensin phosphatase, C2 domain (IPR014020) Protein-tyrosine phosphatase, active site (IPR016130) Bifunctional phosphatidylinositol trisphosphate phosphatase/dual specificity phosphatase PTEN (IPR017361)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014134 AAF52887   AE014134 AAF52888   AE014134 AAF52889   AE014134 AAN10730   AE014134 AAN10731   AE014134 AAN10732   AC005454   AC009849   AE014134 ACZ94222   AF144232 AAF08382   AF161257 AAD45362   AF161258 AAD45363   AF161259 AAD45364   AF201904 AAF23235   AF201905 AAF23236   AF201906 AAF23237   AF201907 AAF23238   AI260874   BE977468   BI165965   BI166802   BI214358   BI243738   BI363888   BI365447   BI481544   BI483179   BQ102888   BT025053   CO187855   CO264295   CO265048   CO275349   CO297781   CO298023   CO300933   CO306518   CO307634   CO316575   CO320748   EC062676   EC073976   EC083619   EC084234   EC087905   EC090071   EC213739   EC221290   EC238057   EC238728   EC245536   EC249846   EL884903   EL885023   EL885024   EL885148   EL885149   EV590572
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9V3L4 Q9Y0B6 Q7KMQ6 Q7KJN5 Q7KJN6 Q9Y0B5 Q9U470
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References sequence variant Pten-misc_feature-24 2L:10,257,510..10,257,518 comment=polymorphic region deleted in some genomic and cDNA clones evidence=experimental (Goberdhan et al., 1999)
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic/larval salivary gland   (Fisher et al., 2012) embryonic/larval salivary gland body   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult crop, larval salivary gland, adult female reproductive system, adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    11 central nervous system, pupae P8    16 head, virgin 1-day female    6 head, virgin 4-day female    9 head, virgin 20-day female    6 head, mated 1-day female    5 head, mated 4-day female    7 head, mated 20-day female    6 head, mated 1-day male    10 head, mated 4-day male    11 head, mated 20-day male    10 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    13 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    6 digestive system, 4-day adult    6 digestive system, 20-day adult    4 fat body, larvae L3 wandering    2 fat body, white prepupae    7 fat body, pupae P8    13 carcass, larvae L3 wandering    7 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    4 ovary, virgin 4-day female    23 ovary, mated 4-day female    12 testis, mated 4-day male    6 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    11 central nervous system, pupae P8    16 head, virgin 1-day female    6 head, virgin 4-day female    9 head, virgin 20-day female    6 head, mated 1-day female    5 head, mated 4-day female    7 head, mated 20-day female    6 head, mated 1-day male    10 head, mated 4-day male    11 head, mated 20-day male    10 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    13 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    6 digestive system, 4-day adult    6 digestive system, 20-day adult    4 fat body, larvae L3 wandering    2 fat body, white prepupae    7 fat body, pupae P8    13 carcass, larvae L3 wandering    7 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    4 ovary, virgin 4-day female    23 ovary, mated 4-day female    12 testis, mated 4-day male    6 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    11 central nervous system, pupae P8    16 head, virgin 1-day female    6 head, virgin 4-day female    9 head, virgin 20-day female    6 head, mated 1-day female    5 head, mated 4-day female    7 head, mated 20-day female    6 head, mated 1-day male    10 head, mated 4-day male    11 head, mated 20-day male    10 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    13 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    6 digestive system, 4-day adult    6 digestive system, 20-day adult    4 fat body, larvae L3 wandering    2 fat body, white prepupae    7 fat body, pupae P8    13 carcass, larvae L3 wandering    7 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    4 ovary, virgin 4-day female    23 ovary, mated 4-day female    12 testis, mated 4-day male    6 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    11 central nervous system, pupae P8    16 head, virgin 1-day female    6 head, virgin 4-day female    9 head, virgin 20-day female    6 head, mated 1-day female    5 head, mated 4-day female    7 head, mated 20-day female    6 head, mated 1-day male    10 head, mated 4-day male    11 head, mated 20-day male    10 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    13 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    6 digestive system, 4-day adult    6 digestive system, 20-day adult    4 fat body, larvae L3 wandering    2 fat body, white prepupae    7 fat body, pupae P8    13 carcass, larvae L3 wandering    7 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    4 ovary, virgin 4-day female    23 ovary, mated 4-day female    12 testis, mated 4-day male    6 accessory gland, mated 4-day male    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    11 central nervous system, pupae P8    16 head, virgin 1-day female    6 head, virgin 4-day female    9 head, virgin 20-day female    6 head, mated 1-day female    5 head, mated 4-day female    7 head, mated 20-day female    6 head, mated 1-day male    10 head, mated 4-day male    11 head, mated 20-day male    10 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    13 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    6 digestive system, 4-day adult    6 digestive system, 20-day adult    4 fat body, larvae L3 wandering    2 fat body, white prepupae    7 fat body, pupae P8    13 carcass, larvae L3 wandering    7 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    4 ovary, virgin 4-day female    23 ovary, mated 4-day female    12 testis, mated 4-day male    6 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    11 central nervous system, pupae P8    16 head, virgin 1-day female    6 head, virgin 4-day female    9 head, virgin 20-day female    6 head, mated 1-day female    5 head, mated 4-day female    7 head, mated 20-day female    6 head, mated 1-day male    10 head, mated 4-day male    11 head, mated 20-day male    10 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    13 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    6 digestive system, 4-day adult    6 digestive system, 20-day adult    4 fat body, larvae L3 wandering    2 fat body, white prepupae    7 fat body, pupae P8    13 carcass, larvae L3 wandering    7 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    4 ovary, virgin 4-day female    23 ovary, mated 4-day female    12 testis, mated 4-day male    6 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    11 central nervous system, pupae P8    16 head, virgin 1-day female    6 head, virgin 4-day female    9 head, virgin 20-day female    6 head, mated 1-day female    5 head, mated 4-day female    7 head, mated 20-day female    6 head, mated 1-day male    10 head, mated 4-day male    11 head, mated 20-day male    10 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    13 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    6 digestive system, 4-day adult    6 digestive system, 20-day adult    4 fat body, larvae L3 wandering    2 fat body, white prepupae    7 fat body, pupae P8    13 carcass, larvae L3 wandering    7 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    4 ovary, virgin 4-day female    23 ovary, mated 4-day female    12 testis, mated 4-day male    6 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    11 central nervous system, pupae P8    16 head, virgin 1-day female    6 head, virgin 4-day female    9 head, virgin 20-day female    6 head, mated 1-day female    5 head, mated 4-day female    7 head, mated 20-day female    6 head, mated 1-day male    10 head, mated 4-day male    11 head, mated 20-day male    10 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    13 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    6 digestive system, 4-day adult    6 digestive system, 20-day adult    4 fat body, larvae L3 wandering    2 fat body, white prepupae    7 fat body, pupae P8    13 carcass, larvae L3 wandering    7 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    4 ovary, virgin 4-day female    23 ovary, mated 4-day female    12 testis, mated 4-day male    6 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of low expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    15 embryo 02-04hr    9 embryo 04-06hr    15 embryo 06-08hr    12 embryo 08-10hr    13 embryo 10-12hr    7 embryo 12-14hr    15 embryo 14-16hr    3 embryo 16-18hr    6 embryo 18-20hr    3 embryo 20-22hr    4 embryo 22-24hr    7 larva L1    3 larva L2    4 larva L3 12hr old    3 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    11 white prepupae new    11 white prepupae 12hr    11 white prepupae 24hr    12 pupae 2d postWPP    11 pupae 3d postWPP    7 pupae 4d postWPP    2 adult male 01day    5 adult male 05day    4 adult male 30day    3 adult female 01day    4 adult female 05day    14 adult female 30day    9 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    15 embryo 02-04hr    9 embryo 04-06hr    15 embryo 06-08hr    12 embryo 08-10hr    13 embryo 10-12hr    7 embryo 12-14hr    15 embryo 14-16hr    3 embryo 16-18hr    6 embryo 18-20hr    3 embryo 20-22hr    4 embryo 22-24hr    7 larva L1    3 larva L2    4 larva L3 12hr old    3 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    11 white prepupae new    11 white prepupae 12hr    11 white prepupae 24hr    12 pupae 2d postWPP    11 pupae 3d postWPP    7 pupae 4d postWPP    2 adult male 01day    5 adult male 05day    4 adult male 30day    3 adult female 01day    4 adult female 05day    14 adult female 30day    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    15 embryo 02-04hr    9 embryo 04-06hr    15 embryo 06-08hr    12 embryo 08-10hr    13 embryo 10-12hr    7 embryo 12-14hr    15 embryo 14-16hr    3 embryo 16-18hr    6 embryo 18-20hr    3 embryo 20-22hr    4 embryo 22-24hr    7 larva L1    3 larva L2    4 larva L3 12hr old    3 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    11 white prepupae new    11 white prepupae 12hr    11 white prepupae 24hr    12 pupae 2d postWPP    11 pupae 3d postWPP    7 pupae 4d postWPP    2 adult male 01day    5 adult male 05day    4 adult male 30day    3 adult female 01day    4 adult female 05day    14 adult female 30day    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    15 embryo 02-04hr    9 embryo 04-06hr    15 embryo 06-08hr    12 embryo 08-10hr    13 embryo 10-12hr    7 embryo 12-14hr    15 embryo 14-16hr    3 embryo 16-18hr    6 embryo 18-20hr    3 embryo 20-22hr    4 embryo 22-24hr    7 larva L1    3 larva L2    4 larva L3 12hr old    3 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    11 white prepupae new    11 white prepupae 12hr    11 white prepupae 24hr    12 pupae 2d postWPP    11 pupae 3d postWPP    7 pupae 4d postWPP    2 adult male 01day    5 adult male 05day    4 adult male 30day    3 adult female 01day    4 adult female 05day    14 adult female 30day    9 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    15 embryo 02-04hr    9 embryo 04-06hr    15 embryo 06-08hr    12 embryo 08-10hr    13 embryo 10-12hr    7 embryo 12-14hr    15 embryo 14-16hr    3 embryo 16-18hr    6 embryo 18-20hr    3 embryo 20-22hr    4 embryo 22-24hr    7 larva L1    3 larva L2    4 larva L3 12hr old    3 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    11 white prepupae new    11 white prepupae 12hr    11 white prepupae 24hr    12 pupae 2d postWPP    11 pupae 3d postWPP    7 pupae 4d postWPP    2 adult male 01day    5 adult male 05day    4 adult male 30day    3 adult female 01day    4 adult female 05day    14 adult female 30day    9 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    15 embryo 02-04hr    9 embryo 04-06hr    15 embryo 06-08hr    12 embryo 08-10hr    13 embryo 10-12hr    7 embryo 12-14hr    15 embryo 14-16hr    3 embryo 16-18hr    6 embryo 18-20hr    3 embryo 20-22hr    4 embryo 22-24hr    7 larva L1    3 larva L2    4 larva L3 12hr old    3 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    11 white prepupae new    11 white prepupae 12hr    11 white prepupae 24hr    12 pupae 2d postWPP    11 pupae 3d postWPP    7 pupae 4d postWPP    2 adult male 01day    5 adult male 05day    4 adult male 30day    3 adult female 01day    4 adult female 05day    14 adult female 30day    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    15 embryo 02-04hr    9 embryo 04-06hr    15 embryo 06-08hr    12 embryo 08-10hr    13 embryo 10-12hr    7 embryo 12-14hr    15 embryo 14-16hr    3 embryo 16-18hr    6 embryo 18-20hr    3 embryo 20-22hr    4 embryo 22-24hr    7 larva L1    3 larva L2    4 larva L3 12hr old    3 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    11 white prepupae new    11 white prepupae 12hr    11 white prepupae 24hr    12 pupae 2d postWPP    11 pupae 3d postWPP    7 pupae 4d postWPP    2 adult male 01day    5 adult male 05day    4 adult male 30day    3 adult female 01day    4 adult female 05day    14 adult female 30day    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    15 embryo 02-04hr    9 embryo 04-06hr    15 embryo 06-08hr    12 embryo 08-10hr    13 embryo 10-12hr    7 embryo 12-14hr    15 embryo 14-16hr    3 embryo 16-18hr    6 embryo 18-20hr    3 embryo 20-22hr    4 embryo 22-24hr    7 larva L1    3 larva L2    4 larva L3 12hr old    3 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    11 white prepupae new    11 white prepupae 12hr    11 white prepupae 24hr    12 pupae 2d postWPP    11 pupae 3d postWPP    7 pupae 4d postWPP    2 adult male 01day    5 adult male 05day    4 adult male 30day    3 adult female 01day    4 adult female 05day    14 adult female 30day    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    18 Schneider line 2 Sg4    7 embryonic 1182-4H    4 embryonic GM2    20 embryonic Kc167    20 embryonic S1    15 embryonic S3    23 leg disc CME L1    6 wing disc CME-W2    22 wing disc ML-DmD8    16 wing disc ML-DmD9    7 wing disc ML-DmD16-c3    10 wing disc ML-DmD21    12 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    19 eye-antennal disc ML-DmD11    14 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    30 tumorous blood cells mbn2    31 ovary fGS/OSS    9 ovary OSC    13 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    18 Schneider line 2 Sg4    7 embryonic 1182-4H    4 embryonic GM2    20 embryonic Kc167    20 embryonic S1    15 embryonic S3    23 leg disc CME L1    6 wing disc CME-W2    22 wing disc ML-DmD8    16 wing disc ML-DmD9    7 wing disc ML-DmD16-c3    10 wing disc ML-DmD21    12 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    19 eye-antennal disc ML-DmD11    14 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2  (30) tumorous blood cells mbn2  (31) ovary fGS/OSS    9 ovary OSC    13 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    18 Schneider line 2 Sg4    7 embryonic 1182-4H    4 embryonic GM2    20 embryonic Kc167    20 embryonic S1    15 embryonic S3    23 leg disc CME L1    6 wing disc CME-W2    22 wing disc ML-DmD8    16 wing disc ML-DmD9    7 wing disc ML-DmD16-c3    10 wing disc ML-DmD21    12 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    19 eye-antennal disc ML-DmD11    14 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    30 tumorous blood cells mbn2    31 ovary fGS/OSS    9 ovary OSC    13 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    18 Schneider line 2 Sg4    7 embryonic 1182-4H    4 embryonic GM2    20 embryonic Kc167    20 embryonic S1    15 embryonic S3    23 leg disc CME L1    6 wing disc CME-W2    22 wing disc ML-DmD8    16 wing disc ML-DmD9    7 wing disc ML-DmD16-c3    10 wing disc ML-DmD21    12 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    19 eye-antennal disc ML-DmD11    14 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    30 tumorous blood cells mbn2    31 ovary fGS/OSS    9 ovary OSC    13 ovary OSS    8 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    18 Schneider line 2 Sg4    7 embryonic 1182-4H    4 embryonic GM2    20 embryonic Kc167    20 embryonic S1    15 embryonic S3    23 leg disc CME L1    6 wing disc CME-W2    22 wing disc ML-DmD8    16 wing disc ML-DmD9    7 wing disc ML-DmD16-c3    10 wing disc ML-DmD21    12 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    19 eye-antennal disc ML-DmD11    14 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    30 tumorous blood cells mbn2    31 ovary fGS/OSS    9 ovary OSC    13 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    18 Schneider line 2 Sg4    7 embryonic 1182-4H    4 embryonic GM2    20 embryonic Kc167    20 embryonic S1    15 embryonic S3    23 leg disc CME L1    6 wing disc CME-W2    22 wing disc ML-DmD8    16 wing disc ML-DmD9    7 wing disc ML-DmD16-c3    10 wing disc ML-DmD21    12 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    19 eye-antennal disc ML-DmD11    14 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2  30 tumorous blood cells mbn2  31 ovary fGS/OSS    9 ovary OSC    13 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    18 Schneider line 2 Sg4    7 embryonic 1182-4H    4 embryonic GM2    20 embryonic Kc167    20 embryonic S1    15 embryonic S3    23 leg disc CME L1    6 wing disc CME-W2    22 wing disc ML-DmD8    16 wing disc ML-DmD9    7 wing disc ML-DmD16-c3    10 wing disc ML-DmD21    12 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    19 eye-antennal disc ML-DmD11    14 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    30 tumorous blood cells mbn2    31 ovary fGS/OSS    9 ovary OSC    13 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    18 Schneider line 2 Sg4    7 embryonic 1182-4H    4 embryonic GM2    20 embryonic Kc167    20 embryonic S1    15 embryonic S3    23 leg disc CME L1    6 wing disc CME-W2    22 wing disc ML-DmD8    16 wing disc ML-DmD9    7 wing disc ML-DmD16-c3    10 wing disc ML-DmD21    12 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    19 eye-antennal disc ML-DmD11    14 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    30 tumorous blood cells mbn2    31 ovary fGS/OSS    9 ovary OSC    13 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    12 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    14 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    16 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    15 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    12 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    14 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    16 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    15 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    12 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    14 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    16 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    15 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    12 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    14 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    16 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    15 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    12 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    14 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    16 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    15 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    12 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    14 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    16 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    15 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    12 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    14 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    16 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    15 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    12 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    14 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    16 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    15 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_05 mE1_20_mRNA_expression_cluster_05
External Data & Images
Linkouts	BDGP expression data • IP16020 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0026379 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5671-RC;CG5671-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Pten Stages(s) 1-3 Stages(s) 4-6 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4arm.PS PtenScer\UAS.cGb lethal, with Scer\GAL4ey.PH PtenScer\UAS.cKa lethal | first instar larval stage, with Scer\GAL4phm.PO PtenScer\UAS.cGb lethal | larval stage | recessive Ptenunspecified lethal | late third instar larval stage (with Df(2L)flp170B) Pten3 lethal | partially | pupal stage, with Scer\GAL4P0206 PtenScer\UAS.cGb lethal | recessive Pten1 Pten3 Ptenc494 partially lethal - majority die, with Scer\GAL4en-e16E PtenScer\UAS.cGa partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237 PtenGD13500 viable Pten2L100 viable, with Scer\GAL4Scer\UAS.cHa, Scer\GAL4tin.cBa PtenScer\UAS.cGb Other Phenotypes Allele aging defective, with Scer\GAL4Mhc.PW PtenScer\UAS.cHa aging defective, with Scer\GAL4Scer\UAS.cHa, Scer\GAL4tin.cBa PtenScer\UAS.cGb chemical resistant, with Scer\GAL4elav-C155 PtenScer\UAS.cGb chemical resistant | adult stage | heat sensitive, with Scer\GAL4elav-C155, Scer\GAL80ts.αTub84B PtenScer\UAS.cGb decreased cell number, with Scer\GAL4ap-md544 PtenScer\UAS.cGb decreased cell number, with Scer\GAL4Bx-MS1096 PtenScer\UAS.cGb decreased cell number, with Scer\GAL4dpp.blk1 PtenScer\UAS.cGa decreased cell number, with Scer\GAL4en-e16E PtenScer\UAS.cGb decreased cell size, with Scer\GAL4ap-md544 PtenScer\UAS.cGb decreased cell size, with Scer\GAL4Bx-MS1096 PtenScer\UAS.cGb decreased cell size, with Scer\GAL4dpp.blk1 PtenScer\UAS.cGa decreased cell size, with Scer\GAL4en-e16E PtenScer\UAS.cGb decreased cell size, with Scer\GAL4ppl.PP PtenScer\UAS.cHa decreased cell size | somatic clone, with Scer\GAL4Act5C.PP PtenScer\UAS.cGb developmental rate defective | second instar larval stage, with Scer\GAL4P0206 PtenScer\UAS.cGb developmental rate defective | third instar larval stage, with Scer\GAL4P0206 PtenScer\UAS.cGb hyperplasia | somatic clone Pten1 Pten3 immune response defective | larval stage, with Scer\GAL4Hml.PG PtenGD13500 increased cell number, with Scer\GAL4nub-AC-62 PtenGD13500 increased cell number (with Pten2L100) Pten117 increased cell number (with Pten117) Pten2L100 increased cell number | recessive | somatic clone Pten117 increased cell number | somatic clone Ptendj189 increased cell size (with Pten2L100) Pten117 increased cell size (with Pten117) Pten2L100 increased cell size | recessive | somatic clone Pten1 Pten117 increased cell size | somatic clone Pten117 Ptendj189 large body (with Pten2L100) Pten117 large body (with Pten117) Pten2L100 large body | pharate adult stage, with Scer\GAL4P0206 PtenScer\UAS.cGb large body | pupal stage, with Scer\GAL4tub.PU PtenGD13500 large body | recessive | somatic clone Pten1 Pten117 large body | second instar larval stage, with Scer\GAL4P0206 PtenScer\UAS.cGb large body | somatic clone Pten117 long lived, with Scer\GAL4Mhc.PW PtenScer\UAS.cHa long lived | RU486 conditional, with Scer\GAL4bun-Switch1.32 PtenScer\UAS.cGb neuroanatomy defective | cell autonomous | somatic clone PtenMGH1 neuroanatomy defective | larval stage, with Scer\GAL4C57 Ptendj189 PtendsRNA.Exel.Scer\UAS neuroanatomy defective | larval stage, with Scer\GAL4ppk.PG PtenScer\UAS.cHa neurophysiology defective | larval stage, with Ptendj189, Scer\GAL4C57 PtendsRNA.Exel.Scer\UAS neurophysiology defective | larval stage, with PtendsRNA.Exel.Scer\UAS, Scer\GAL4C57 Ptendj189 planar polarity defective | recessive | somatic clone Pten1 short lived | RU486 conditional, with Scer\GAL4elav.Switch.PO PtenScer\UAS.cGb size defective, with Scer\GAL4nub-AC-62 PtenGD13500 size defective | adult stage, with Scer\GAL4en-e16E PtendsRNA.Exel.Scer\UAS size defective | dominant Ptendj189 small body, with Scer\GAL4arm.PS PtenScer\UAS.cGb stress response defective (with Pten2L100) Pten117 stress response defective (with Pten117) Pten2L100 visible, with Scer\GAL4ap-md544 PtenScer\UAS.cGa visible, with Scer\GAL4ci.PU PtenScer\UAS.cGa visible, with Scer\GAL4ey.PH PtenScer\UAS.cGb PtenScer\UAS.cHa PtenScer\UAS.cKa PtenScer\UAS.cSa visible, with Scer\GAL4GMR.PF PtenScer\UAS.cHa PtenScer\UAS.cKa PtenScer\UAS.cUa visible, with Scer\GAL4pnr-MD237 PtenGD13500 visible, with Scer\GAL4salm.PU PtenScer\UAS.cGa visible | adult stage, with Scer\GAL4en-e16E PtendsRNA.Exel.Scer\UAS visible | first instar larval stage, with Scer\GAL4hs.PB PtenScer\UAS.cSa visible | recessive | somatic clone Pten117 visible | somatic clone Pten117 Ptenc494 Ptenunspecified wild-type Pten+t6.2 Pten+t6.3 Ptenhs.PG wild-type | RU486 conditional, with Scer\GAL4Switch1.106 PtenScer\UAS.cGb Phenotype manifest in Allele abdominal tracheal primordium 1 | germline clone | maternal effect Ptenc494 abdominal tracheal primordium 2 | germline clone | maternal effect Ptenc494 adult head Pten117 adult head | somatic clone Pten117 adult heart, with Scer\GAL4Scer\UAS.cHa, Scer\GAL4tin.cBa PtenScer\UAS.cGb blastoderm embryo | germline clone | maternal effect Ptendj189 cell cycle, with Scer\GAL4ey.PH PtenScer\UAS.cHa chaeta | supernumerary, with Scer\GAL4pnr-MD237 PtenGD13500 cleavage stage embryo | germline clone | maternal effect Ptendj189 crossvein | somatic clone Pten1 Pten3 dendrite | cell autonomous | somatic clone PtenMGH1 dendrite | larval stage, with Scer\GAL4ppk.PG PtenScer\UAS.cHa egg | germline clone | maternal effect Ptendj189 egg | maternal effect Ptenc494 embryonic/first instar larval cuticle | first instar larval stage, with Scer\GAL4hs.PB PtenScer\UAS.cSa embryonic/larval corpus allatum, with Scer\GAL4P0206 PtenScer\UAS.cGb embryonic/larval fat body, with Scer\GAL4ppl.PP PtenScer\UAS.cHa embryonic/larval fat body | somatic clone, with Scer\GAL4Act5C.PP PtenScer\UAS.cGb embryonic/larval fat body | somatic clone | third instar larval stage, with Scer\GAL4Act5C.PP PtenJF01987 PtenKK109278 embryonic/larval neuroblast, with Scer\GAL4nab PtenScer\UAS.cHa embryonic/larval salivary gland, with Scer\GAL429BD PtenScer\UAS.cGb embryonic/larval salivary gland | somatic clone, with Scer\GAL4Act5C.PP PtenScer\UAS.cGb eye, with Scer\GAL4ey.PH PtenScer\UAS.cGb PtenScer\UAS.cHa PtenScer\UAS.cSa eye, with Scer\GAL4GMR.PF PtenScer\UAS.cUa PtenScer\UAS.cGb PtenScer\UAS.cHa PtenScer\UAS.cKa eye | somatic clone Pten1 Pten117 Pten3 Ptendj189 Ptenunspecified eye disc, with Scer\GAL4ey.PH PtenScer\UAS.cHa eye disc, with Scer\GAL4GMR.PF PtenScer\UAS.cHa eye disc | somatic clone Pten1 Ptendj189 eye photoreceptor cell, with Scer\GAL4GMR.PF PtenScer\UAS.cHa eye photoreceptor cell | somatic clone Pten1 Ptendj189 fat body, with Scer\GAL4Lsp2.PH PtenScer\UAS.cGb gastrula embryo | germline clone | maternal effect Ptendj189 head capsule | somatic clone Pten117 interommatidial bristle | somatic clone Pten1 Pten3 Ptendj189 lens, with Scer\GAL4GMR.PF PtenScer\UAS.cHa lipid droplet & larval oenocyte, with Scer\GAL4ppl.PP PtenScer\UAS.cHa lipid particle & nurse cell | somatic clone Pten1 mesothoracic tergum, with Scer\GAL4pnr-MD237 PtenGD13500 mesothoracic tracheal primordium | germline clone | maternal effect Ptenc494 metathoracic tracheal primordium | germline clone | maternal effect Ptenc494 muscle cell, with Scer\GAL4Mhc.PW PtenScer\UAS.cHa NMJ bouton, with Ptendj189, Scer\GAL4C57 PtendsRNA.Exel.Scer\UAS NMJ bouton, with PtendsRNA.Exel.Scer\UAS, Scer\GAL4C57 Ptendj189 NMJ bouton, with Scer\GAL4C57 PtendsRNA.Exel.Scer\UAS nurse cell & actin cytoskeleton | germ-line clone Ptendj189 nurse cell & nucleus | germ-line clone Ptendj189 nurse cell | germline clone Ptendj189 ommatidial precursor cluster | somatic clone Pten1 ommatidium, with Scer\GAL4ey.PH PtenScer\UAS.cHa ommatidium, with Scer\GAL4GMR.PF PtenScer\UAS.cUa PtenScer\UAS.cGb PtenScer\UAS.cHa ommatidium | somatic clone Pten1 Pten117 Pten3 Ptenc494 Ptendj189 photoreceptor cell | cell autonomous | somatic clone Pten1 Pten3 photoreceptor cell | somatic clone Ptenc494 pigment cell, with Scer\GAL4GMR.PF PtenScer\UAS.cHa pole cell | germline clone | maternal effect Ptendj189 prothoracic gland, with Scer\GAL4P0206 PtenScer\UAS.cGb puparium, with Scer\GAL4P0206 PtenScer\UAS.cGb rhabdomere, with Scer\GAL4GMR.PF PtenScer\UAS.cHa rhabdomere | cell autonomous | somatic clone Pten1 Pten3 rhabdomere | somatic clone Pten1 tracheal primordium | ectopic | germline clone | maternal effect Ptenc494 tracheal primordium | germline clone | maternal effect Ptenc494 wing Ptendj189 wing, with Scer\GAL4Bx-MS1096 PtenScer\UAS.cGb wing, with Scer\GAL4ci.PU PtenScer\UAS.cGa wing, with Scer\GAL4dpp.blk1 PtenScer\UAS.cGa wing, with Scer\GAL4en-e16E PtendsRNA.Exel.Scer\UAS wing, with Scer\GAL4nub-AC-62 PtenGD13500 wing, with Scer\GAL4P0206 PtenScer\UAS.cGb wing, with Scer\GAL4salm.PU PtenScer\UAS.cGa wing & cell | somatic clone Pten1 Pten3 wing | dorsal compartment, with Scer\GAL4ap-md544 PtenScer\UAS.cGb wing | posterior compartment, with Scer\GAL4en-e16E PtenScer\UAS.cGa PtenScer\UAS.cGb wing | somatic clone Pten1 Pten3 wing blade, with Scer\GAL4ap-md544 PtenScer\UAS.cGa wing disc Ptenunspecified wing hair | ectopic | somatic clone Pten1 Pten3 wing margin bristle | somatic clone Ptendj189
Classical Alleles ( 12 )
For All Classical Alleles Show
Allele of Pten Class Mutagen Stocks Known lesion PtenC076 1 -- Ptenf04844 1 -- Pten117 loss of function allele 0 Yes Pten1 ethyl methanesulfonate 0 -- Pten2L100 hypomorphic allele - genetic evidence 0 Yes Pten3 ethyl methanesulfonate 0 -- Ptenc494 loss of function allele ethyl methanesulfonate 0 Yes Ptendj189 0 Yes PtenMGH1 ethyl methanesulfonate 0 -- Ptenmgh3 0 -- PtenMGH6 0 -- Ptenunspecified 0 --
Alleles Carried on Transgenic Constructs ( 30 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Pten Class Mutagen Stocks Known lesion PtendsRNA.Exel.Scer\UAS in vitro construct - RNAi in vitro construct - regulatory fusion 3 Yes PtenGD13500 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes PtenHMS00044 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes PtenJF01859 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes PtenJF01987 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes PtenKK109278 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Pten+t6.2 in vitro construct - genomic fragment 0 Yes Pten+t6.3 in vitro construct - genomic fragment 0 Yes Pten+t6 in vitro construct - genomic fragment 0 Yes Pten1.Act5C.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Pten2.Act5C.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Pten2.cvSa in vitro construct 0 Yes Pten2.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Pten3.Act5C.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Pten3.cvSa in vitro construct 0 Yes Pten3.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Ptena.cRa in vitro construct - RNAi 0 Yes PtencRa in vitro construct - RNAi 0 Yes PtendsRNA.cCa in vitro construct - RNAi 0 Yes PtendsRNA.cGa in vitro construct - RNAi 0 Yes PtendsRNA.cPa in vitro construct - RNAi 0 Yes PtendsRNA.cSa in vitro construct - RNAi 0 Yes Ptenhs.PG in vitro construct - regulatory fusion 0 Yes PtenNIG.5671R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes PtenScer\UAS.cGa 0 Yes PtenScer\UAS.cGb in vitro construct - regulatory fusion 0 -- PtenScer\UAS.cHa in vitro construct - regulatory fusion 0 Yes PtenScer\UAS.cKa in vitro construct - regulatory fusion 0 Yes PtenScer\UAS.cSa in vitro construct - regulatory fusion 0 Yes PtenScer\UAS.cUa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel6026 (Ryder, 2004.4.26) Df(2L)flp170B (Goberdhan et al., 1999) Df(2L)J1 (Huang et al., 1999)
Not disrupted in	Df(2L)41C (Goberdhan et al., 1999) Df(2L)flp147E (Goberdhan et al., 1999)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data heat-shock construct P{hs-Pten.G} NA UAS construct P{GD13500} NA P{KK109278} NA P{NIG.5671R} NA P{TRiP.HMS00044} NA P{TRiP.JF01859} NA P{TRiP.JF01987} NA P{UAS-Pten.2.GFP} NA P{UAS-Pten.3.GFP} NA P{UAS-Pten.dsRNA.Exel} NA P{UAS-Pten.G} NA P{UAS-Pten.Gb} NA P{UAS-Pten.H} NA P{UAS-Pten.K} NA P{UAS-Pten.S} NA P{UAS-Pten.U} NA characterization construct P{Pten.6.2} NA P{Pten.6.3.vivI} NA P{Pten.6} NA P{UAS-PTEN-DH218} NA P{UAS-PTEN-DHH} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions F{}Ptendj189 NA PBac{3HPy+}PtenC076 NA PBac{WH}Ptenf04844 NA
Gene Ontology: Function, Process & Cellular Component ( 54 unique terms )
Terms Based on Experimental Evidence ( 34 terms )
Molecular Function
CV term Evidence References
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity inferred from genetic interaction with Pi3K92E AND inferred from sequence or structural similarity with human PTEN (Goberdhan et al., 1999) phosphoprotein phosphatase activity inferred from mutant phenotype (Huang et al., 1999) protein serine/threonine phosphatase activity inferred from mutant phenotype (Gao et al., 2005)
Biological Process
CV term Evidence References
actin cytoskeleton organization inferred from mutant phenotype (von Stein et al., 2005) actin filament organization inferred from mutant phenotype (Kiger et al., 2003) apoptotic process inferred from mutant phenotype (Huang et al., 1999) autophagy inferred from mutant phenotype (Rusten et al., 2004) cell adhesion inferred from mutant phenotype (Kiger et al., 2003) cell proliferation inferred from mutant phenotype (Goberdhan et al., 1999, Gao et al., 2000) cellular process inferred from mutant phenotype (Gao et al., 2000) cytoskeleton organization inferred from mutant phenotype (Goberdhan et al., 1999) dendrite regeneration inferred from mutant phenotype (Song et al., 2012) epithelial cell fate determination, open tracheal system inferred from mutant phenotype (Jin et al., 2001) insulin receptor signaling pathway inferred from genetic interaction with Pi3K92E AND inferred from genetic interaction with chico (Huang et al., 1999) larval development inferred from mutant phenotype (Mirth et al., 2005) larval salivary gland morphogenesis inferred from mutant phenotype (Takeo et al., 2005) lipid metabolic process inferred from mutant phenotype (Gutierrez et al., 2007) lipid storage inferred from mutant phenotype (Vereshchagina and Wilson, 2006) melanotic encapsulation of foreign target inferred from mutant phenotype (Howell et al., 2012) metamorphosis inferred from mutant phenotype (Mirth et al., 2005) negative regulation of axon regeneration inferred from mutant phenotype (Song et al., 2012) negative regulation of multicellular organism growth inferred from mutant phenotype (Oldham et al., 2002) negative regulation of organ growth inferred from mutant phenotype (Scanga et al., 2000) organ morphogenesis inferred from mutant phenotype (Gao et al., 2000) protein dephosphorylation inferred from mutant phenotype (Gao et al., 2005) regulation of autophagy inferred from mutant phenotype (Pircs et al., 2012) regulation of cell shape inferred from mutant phenotype (Goberdhan et al., 1999, Kiger et al., 2003) regulation of cell size inferred from mutant phenotype (Huang et al., 1999, Goberdhan et al., 1999) regulation of dendrite development inferred from mutant phenotype (Parrish et al., 2009) regulation of hemocyte proliferation inferred from mutant phenotype (Sinenko et al., 2010) regulation of multicellular organism growth inferred from mutant phenotype (Mirth et al., 2005) response to starvation inferred from mutant phenotype (Oldham et al., 2002) rhabdomere development inferred from mutant phenotype (Pinal et al., 2006) tissue development inferred from mutant phenotype (Gao et al., 2000)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 27 terms )
Molecular Function
CV term Evidence References
actin binding inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000) magnesium ion binding inferred from electronic annotation with InterPro:IPR017361 (FlyBase Curators et al., 2004-) non-membrane spanning protein tyrosine phosphatase activity inferred from sequence or structural similarity (Huang et al., 1999) PDZ domain binding inferred from electronic annotation with InterPro:IPR017361 (FlyBase Curators et al., 2004-) phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity inferred from electronic annotation with InterPro:IPR017361 (FlyBase Curators et al., 2004-) phosphoprotein phosphatase activity inferred from sequence or structural similarity with human PTEN (Goberdhan et al., 1999) protein tyrosine/serine/threonine phosphatase activity inferred from electronic annotation with InterPro:IPR000340 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Huang et al., 1999) non-traceable author statement (Morrison et al., 2000) protein tyrosine phosphatase activity inferred from sequence or structural similarity with human PTEN (Mi et al., 2001.12.13)
Biological Process
CV term Evidence References
apoptotic process traceable author statement (Claeys et al., 2002) inositol phosphate dephosphorylation inferred from electronic annotation with InterPro:IPR017361 (FlyBase Curators et al., 2004-) insulin receptor signaling pathway non-traceable author statement (Johnston and Gallant, 2002) negative regulation of cell cycle traceable author statement (Claeys et al., 2002) negative regulation of cell growth non-traceable author statement (Johnston and Gallant, 2002) negative regulation of cell migration inferred from electronic annotation with InterPro:IPR017361 (FlyBase Curators et al., 2004-) negative regulation of cell proliferation inferred from electronic annotation with InterPro:IPR017361 (FlyBase Curators et al., 2004-) negative regulation of cell size traceable author statement (Weinkove and Leevers, 2000, Potter and Xu, 2001) negative regulation of focal adhesion assembly inferred from electronic annotation with InterPro:IPR017361 (FlyBase Curators et al., 2004-) negative regulation of growth traceable author statement (Oldham and Hafen, 2003) negative regulation of insulin receptor signaling pathway non-traceable author statement (Claeys et al., 2002) traceable author statement (Oldham et al., 2000, Potter and Xu, 2001) negative regulation of organ growth non-traceable author statement (Weinkove and Leevers, 2000) traceable author statement (Oldham et al., 2000, Potter and Xu, 2001) negative regulation of protein kinase B signaling cascade inferred from electronic annotation with InterPro:IPR017361 (FlyBase Curators et al., 2004-) phosphatidylinositol dephosphorylation inferred from electronic annotation with InterPro:IPR017361 (FlyBase Curators et al., 2004-) non-traceable author statement (Oldham and Hafen, 2003) traceable author statement (Oldham et al., 2000) protein dephosphorylation inferred from sequence or structural similarity with human PTEN (Goberdhan et al., 1999) non-traceable author statement (Morrison et al., 2000) regulation of cell size non-traceable author statement (Claeys et al., 2002) regulation of multicellular organism growth non-traceable author statement (Claeys et al., 2002) regulation of organ growth non-traceable author statement (Claeys et al., 2002) regulation of protein stability inferred from electronic annotation with InterPro:IPR017361 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Pten - 128up anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pten - AP-2α anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pten - ATPsyn-γ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pten - Arc1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pten - CG10077 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pten - CG10306 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pten - CG10418 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pten - CG11107 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pten - CG11266 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pten - CG1416 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pten - CG16940 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pten - CG17454 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pten - CG17691 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pten - CG2065 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pten - CG31694 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pten - CG31739 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pten - CG3731 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pten - CG3817 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pten - CG3862 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pten - CG4169 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pten - CG4553 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pten - CG4611 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pten - CG4849 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pten - CG5726 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pten - CG6453 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pten - CG6701 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pten - CG7878 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pten - CG8545 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pten - CG9769 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pten - Chc anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pten - Chd64 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pten - CkIIα anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pten - Cyp12d1-p anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pten - FK506-bp2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pten - Gp210 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pten - Int6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pten - LKR anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pten - LanB1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pten - Ote anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pten - P32 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pten - Prp8 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pten - RpL7-like anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pten - RpLP0 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pten - RpS10a anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pten - RpS19a anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pten - RpS29 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pten - Rpt2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pten - Rrp40 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pten - Rrp46 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pten - SmD2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pten - SmD3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pten - SmG anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pten - Srp54 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pten - U4-U6-60K anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pten - cathD anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pten - cher anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pten - coil anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pten - dod anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pten - eIF-2β anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pten - eIF3-S8 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pten - isoQC anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pten - kst anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pten - l(1)G0230 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pten - l(1)G0320 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pten - l(3)72Ab anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pten - mRpL21 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pten - mRpL3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pten - mRpL50 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pten - mRpS24 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pten - mTerf3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pten - me31B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pten - mod anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pten - mts anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pten - ppan anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pten - scny anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pten - tws anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pten - εCOP anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Pten allele Gene References Pten1 Pi3K92E (Goberdhan et al., 1999) Pten2L100 Pi3K21B (Oldham et al., 2002) Pten117 foxo (Junger et al., 2003) lilli (Wittwer et al., 2001) Pi3K21B (Oldham et al., 2002) Tor (Oldham et al., 2000) Ptenc494 Pdk1 (Rintelen et al., 2001) Ptendj189 Akt1 (Gao et al., 2000) eIF-4a (Gao et al., 2000) Pdk1 (Rintelen et al., 2001) Pi3K92E (Gao et al., 2000) PtenScer\UAS.cGa Pi3K92E (Goberdhan et al., 1999) PtenScer\UAS.cGb EcR (Rusten et al., 2004) Pi3K92E (Gao et al., 2000) Tsc1 (Tapon et al., 2001) PtenScer\UAS.cHa chico (Huang et al., 1999) InR (Huang et al., 1999) Pi3K92E (Huang et al., 1999) Ptenunspecified Akt1 (Stocker et al., 2002) unspecified Akt1 (Kiger et al., 2003) CG34384 (Kiger et al., 2003) DJ-1α (Kim et al., 2005) gig (Tapon et al., 2001) LIMK1 (Kiger et al., 2003) MAPk-Ak2 (Kiger et al., 2003) Pi3K92E (Kiger et al., 2003) rictor (Hietakangas and Cohen, 2007) slpr (Kiger et al., 2003) wee (Kiger et al., 2003)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 68762 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0026379 DroID - A comprehensive database of gene and protein interactions. • FBgn0026379 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43991 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q9U470
Orthologs
OrthoDB Orthologs (50) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6X982V Dipteran inclusive ortholog search EOG6640M9 Insect inclusive ortholog search EOG69W19H Arthropod inclusive ortholog search EOG6C867J Metazoa inclusive ortholog search EOG69WF7X
Orthologs in Drosophila Species (EOG6X982V)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Pten     Drosophila simulans   Dsim\GD22287 Y   Drosophila sechellia   Dsec\GM11890 Y   Drosophila erecta   Dere\GG23962 Y   Drosophila yakuba   Dyak\GE26252 Y   Drosophila ananassae   Dana\GF14124 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA19047 Y   Drosophila persimilis   Dper\GL19174 Y   Drosophila willistoni   Dwil\GK15265 Y   Drosophila virilis   Dvir\GJ17528 Y   Drosophila mojavensis   Dmoj\GI18266 Y   Drosophila grimshawi   Dgri\GH13854 Y
Orthologs in non-Drosophila Dipterans (EOG6640M9)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL017224   Anopheles gambiae Malaria mosquito  Agam\AGAP009628   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ008808
Orthologs in non-Dipteran Insects (EOG69W19H)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\Pten   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG012645   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH19352   Atta cephalotes Leafcutter ant  Acep\ACEP12490   Camponotus floridanus Florida carpenter ant  Cflo\CFLO14113   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL22738   Linepithema humile Argentine ant  Lhum\LH15756   Pogonomyrmex barbatus Red harvester ant  Pbar\PB27195   Solenopsis invicta Red fire ant  Sinv\SINV15538   Acyrthosiphon pisum Pea aphid  Apim\ACYPI004294   Bombyx mori Silkmoth  Bmor\BGIBMGA009071   Pediculus humanus Human body louse  Phum\PHUM471760   Tribolium castaneum Red flour beetle  Tcas\TC005314
Orthologs in non-Insect Arthropods (EOG6C867J)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\l(3)87Df   Daphnia pulex Water flea  Dpux\rbcL   Ixodes scapularis Deer tick  Isca\ISCW021211
Orthologs in non-Arthropod Metazoa (EOG69WF7X)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\daf-18   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_003142gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_009522gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_023882gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_002928gn   Danio rerio Zebrafish  Drer\tpte   Danio rerio Zebrafish  Drer\ptenb   Danio rerio Zebrafish  Drer\ptena   Xenopus tropicalis Western clawed frog  Xtro\tpte2   Xenopus tropicalis Western clawed frog  Xtro\pten   Gallus gallus Domestic chicken  Ggal\TPTE   Gallus gallus Domestic chicken  Ggal\PTEN   Mus musculus House mouse  Mmus\Pten   Mus musculus House mouse  Mmus\Tpte   Rattus norvegicus Norway rat  Rnor\Pten   Rattus norvegicus Norway rat  Rnor\Tpte   Homo sapiens Human  Hsap\TPTE   Homo sapiens Human  Hsap\ENSG00000132958   Homo sapiens Human  Hsap\PTEN
Human Orthologs (3)
Gene OMIM HGNC Hsap\TPTE     Hsap\ENSG00000132958     Hsap\PTEN
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD22287 Drosophila sechellia Dsec\GM11890 Drosophila erecta Dere\GG23962 Drosophila yakuba Dyak\GE26252 Drosophila ananassae Dana\GF14124 Drosophila pseudoobscura pseudoobscura Dpse\GA19047 Drosophila persimilis Dper\GL19174 Drosophila willistoni Dwil\GK15265 Drosophila virilis Dvir\GJ17528 Drosophila mojavensis Dmoj\GI18266 Drosophila grimshawi Dgri\GH13854
Stocks & Reagents
Stocks Listed in FlyBase ( 10 )
Bloomington	8550 w1118; P{UAS-Pten.dsRNA.Exel}3 25841 y1 v1; P{TRiP.JF01859}attP2 33643 y1 v1; P{TRiP.HMS00044}attP2 8548 P{UAS-Pten.dsRNA.Exel}1, y1 w1118 8549 y1 w1118; P{UAS-Pten.dsRNA.Exel}2 25967 y1 v1; P{TRiP.JF01987}attP2/TM3, Sb1 16275 y1 w1118; PBac{3HPy+}PtenC076/CyO
Harvard	- PBac{WH}Ptenf04844
VDRC	v101475 P{KK109278}VIE-260B v35731 w1118; P{GD13500}v35731
Genomic Clones ( 2 )
	BACR07H08 BACR30M19 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 40 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	IP16020
Other clones	DPiM_IP16020
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LP04865 RE05970 RE07023 RE20136 RE41458 RE48862 RE50762 RE64115 RE66028
Other clones	14870 30423 31540 46802 54792 56960 103607 104644 148894 161485 165423 180184 bs64d06 Dmel_neb_013338_0438_1077 EK034305 EK117232 EK138431 EK141358 EK170529 EK171137 EK179719 EK251309 EK255133 EK265318 EK287932 IP16120 IP16220 IP16320 UUGC0282
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0026379 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43991
Antibody Information
	polyclonal (Ramachandran et al., 2009)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Pten CG5671 (Bayraktaroglu, 2000.4.13)
Additional comments
Other Comments
	dsRNA has been made from templates generated with primers directed against this gene. (Frias et al., 2006) dsRNA made from templates generated with primers directed against this gene results in an increase in mean cell diameter. (Guertin et al., 2006) dsRNA made from templates generated with primers directed against this gene increase the levels of phosphorylation of boh Akt1 and S6k in S2 cells. (Yang et al., 2006) dsRNA made from templates generated with primers directed against this gene used to treat S2 cells. (Yang et al., 2006) One of 42 Drosophila genes identified as being most likely to reveal molecular and cellular mechanisms of nervous system development or plasticity relevant to human Mental Retardation disorders. (Inlow and Restifo, 2004) PI3K activity is regulated through EcR signalling in a cell-autonomous manner to allow programmed autophagy in the fat body. (Rusten et al., 2004) RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167 cells: change from round to spindle-shaped, with the formation of F-actin puncta and microtubule extensions. Alterations of cell shape are also evident in S2R+ cells - they become round and detached. The Kc167 cell-shape change is suppressed by simultaneous treatment with dsRNA targetted against Akt1, CG31187, LIMK1, MAPk-Ak2, Pi3K92E, slpr or wee. (Kiger et al., 2003) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) Pten plays an essential role in the control of, cell size, cell number, and organ size. (Gao et al., 2000) Pten acts antagonistically to Pi3K92E and chico. In direction of increasing cytology: chico- bsk- Ror+ Pten- (Goberdhan et al., 1999) Pten has a complex role in regulating tissue and body size. Pten regulates the subcellular organization of the actin cytoskeleton in multiple cell types. (Goberdhan et al., 1999) Both inactivation and overexpression of Pten affect cell size, and overexpression of Pten inhibits cell cycle progression at early mitosis and promotes cell death during eye development. Phenotypes caused by overexpression of Hsap\PTEN and Pten are indistinguishable. (Huang et al., 1999) The phosphatase activity of Pten is necessary for it to exert its functions during development. In direction of increasing cytology: Rsf1+ Pten+ CG5676+ Ror- bsk+ chico+ (Huang et al., 1999) Pten acts in the insulin signalling pathway. All signals from the InR protein can be antagonized by Pten. (Huang et al., 1999) Pten regulates cell size and cell proliferation via the actin cytoskeleton. (Wilson et al., 1999)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_058074 NM_058075 NM_058076 NM_134320 NM_134321 NM_134322 NM_001169462 RefSeq (Proteins) • NP_477422 NP_477423 NP_477424 NP_599147 NP_599148 NP_599149 NP_001162933 DDBJ / EMBL / GenBank • AAD45362 AAD45363 AAD45364 AAF08382 AAF23235 AAF23236 AAF23237 AAF23238 AAF52887 AAF52888 AAF52889 AAN10730 AAN10731 AAN10732 AC005454 AC009849 ACZ94222 AF144232 AF161257 AF161258 AF161259 AF201904 AF201905 AF201906 AF201907 AI260874 Entrez Gene - A searchable database of RefSeq genes. • 43991 UniProtKB/TrEMBL • Q7KJN5 Q7KJN6 Q7KMQ6 Q9U470 Q9V3L4 Q9Y0B5 Q9Y0B6
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Dual specificity phosphatase, catalytic domain (IPR000340) C2 calcium/lipid-binding domain, CaLB (IPR008973) Phosphatase tensin type (IPR014019) Tensin phosphatase, C2 domain (IPR014020) Protein-tyrosine phosphatase, active site (IPR016130) Bifunctional phosphatidylinositol trisphosphate phosphatase/dual specificity phosphatase PTEN (IPR017361) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • IP16020
Linkouts
	BioGRID - A database of protein and genetic interactions • 68762 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0026379 DroID - A comprehensive database of gene and protein interactions. • FBgn0026379 DRSC - Results from RNAi screens. • FBgn0026379 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0026379 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5671-RC;CG5671-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0026379 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43991 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /cytoskel/pten1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43991 modMine - Data generated by the modENCODE project. • FBgn0026379 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q9U470
Synonyms & Secondary IDs ( 15 )
Reported As
Symbol Synonym	CG5671 (Goldstein and Gunawardena, 2000, Morrison et al., 2000, Perkins et al., 1.15.2009, Keleman et al., 2009.8.5, Ni et al., 2010.12.1, Howell et al., 2012) dPTEN (Wu et al., 2005, Sarbassov et al., 2005, Wessells et al., 2004, Burgering and Kops, 2002, Findlay et al., 2005, Maehama et al., 2004, Junger et al., 2003, Szuplewski et al., 2003, Raisin et al., 2003, Jin et al., 2001, Downward and Leevers, 2001, Oldham and Hafen, 2003, Marygold and Leevers, 2002, Radimerski et al., 2002, Prober and Edgar, 2002, Stocker et al., 2002, Oldham et al., 2002, Kozma and Thomas, 2002, Britton et al., 2002, Rintelen et al., 2001, Gingras et al., 2001, Potter et al., 2001, Zhang et al., 2000, Stocker and Hafen, 2000, Gao et al., 2000, Huang et al., 1999, DiAngelo and Birnbaum, 2007, Yang et al., 2006, Gao et al., 2005, Yang et al., 2006, DiAngelo and Birnbaum, 2006, Kim et al., 2005, Cavaliere et al., 2005, Miron et al., 2003, Trotta et al., 2005, Dekanty et al., 2005, Kim et al., 2008, Lizcano et al., 2003, Read et al., 2009, Montagne et al., 2010, Song et al., 2007, Honegger et al., 2008, Porstmann et al., 2008, Kim et al., 2004) DPTEN (Partridge, 2005, Claeys et al., 2002, Towers and Sattelle, 2002, Goberdhan and Wilson, 2002, Goberdhan and Wilson, 2002, Coelho and Leevers, 2000, Clemens et al., 2000, Potter et al., 2000, Goberdhan et al., 1999, Smith et al., 1999, Wilson et al., 1999, Scanga et al., 2000) dPten (Wittwer et al., 2005) dpten (Ma et al., 2008) pten (McNeill et al., 2008, Bateman and McNeill, 2004, Lee and Orr-Weaver, 2003, Menut et al., 2007, Ramachandran et al., 2009, Wang et al., 2009, Wang et al., 2012, Hafezi et al., 2012, Killip and Grewal, 2012) PTEN (Mirth et al., 2005, Shingleton, 2005, Cygnar et al., 2005, Scott et al., 2004, Scott et al., 2004, Pan et al., 2004, McNeill and Bateman, 2005, Bilder, 2004, von Stein et al., 2003, Clague et al., 2004, von Stein et al., 2004, Gao et al., 2002, Oldham et al., 2001, Neufeld, 2001.1.11, Wilson et al., 2000, Weinkove and Leevers, 2000, Potter et al., 2000, Smith, 1999.6.23, Smith, 1999.6.23, Smith, 1999.6.23, Edgar, 2006, Vereshchagina and Wilson, 2006, Tyler et al., 2007, Palmer and Pichaud, 2007, Wilson et al., 2007, Fehon, 2006, Mikeladze-Dvali et al., 2005, Edgar, 2006, Betschinger et al., 2006, Guertin et al., 2006, Bergman et al., 2007, Frias et al., 2006, Cortina-Andrada et al., 2007, Basu and Krek, 2007, Shiojima, 2006, Gutierrez et al., 2007, Hoshizaki and Gibbs, 2007, Libert, 2007, Frias et al., 2006, Howlett et al., 2008, Ikeya et al., 2009, Seisenbacher et al., 2008, Hietakangas and Cohen, 2007, Hardie, 2003, Mesquita et al., 2010, Géminard et al., 2009, Scanga et al., 2000, Tsuda et al., 2010, Park et al., 2011, Tang et al., 2011, Bakal et al., 2008, Jovceva et al., 2007, Vereshchagina et al., 2008, Rafel and Milán, 2008, Lee et al., 2008, Lee et al., 2010, Hall et al., 2007, Read et al., 2009, Shelly et al., 2009, Ninov et al., 2009, Juhász et al., 2007, Nuzhdin et al., 2009, Mattila et al., 2008, Pinal et al., 2006, Werz et al., 2009, Zheng and Sehgal, 2010, Delanoue et al., 2010, Tsuda et al., 2010, Honegger et al., 2008, Friedman et al., 2011, Resnik-Docampo and de Celis, 2011, Montagne et al., 2010, Lindmo et al., 2006, Poon et al., 2011, Okamoto et al., 2013, Gault et al., 2012) Pten (Wiggin et al., 2005, Bruckner et al., 2004, Knox et al., 2007, Friedman and Perrimon, 2006, Nedelsky et al., 2010, Chen et al., 2007, Zhai et al., 2012, Yin et al., 2008, Sinenko et al., 2010, Zhou et al., 2008, Lindquist et al., 2011, Hou et al., 2008, Demontis and Perrimon, 2009, Rhiner et al., 2009, Alvarez-Ponce et al., 2009, Lee et al., 2010, Mirth et al., 2009, Ford et al., 2007, Qian and Bodmer, 2009, Parrish et al., 2009, Doumanis et al., 2009, Mummery-Widmer et al., 2009, Sims et al., 2009, Kim et al., 2010, Sousa-Nunes et al., 2011, Haberman et al., 2010, Djiane et al., 2011, Demontis and Perrimon, 2010, Eddison et al., 2011, Wheeler et al., 2004, Howell et al., 2012, Tokusumi et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Song et al., 2012, Justiniano et al., 2012, Marinari et al., 2012, Pircs et al., 2012) PTEN3 (Goldstein and Gunawardena, 2000)
Name Synonym	Drosophila phosphatase and tensin homologue deleted on chromosome 10 (Lizcano et al., 2003) phosphatase and tensin homolog (Lee et al., 2010) Phosphatase and tensin homologue (Lee et al., 2008) phosphatidylinositol (3,4,5)-trisphosphate phosphatase (Jovceva et al., 2007) PI 3-phosphatase (Hardie, 2003) PtdIns(3,4,5)P3 phosphatase (Jovceva et al., 2007) Pten (Zhou et al., 2008, Mummery-Widmer et al., 2009, Justiniano et al., 2012) PTEN (Hall et al., 2007)
Secondary FlyBase IDs
	FBgn0032201
References ( 261 )
Generate a list of	All references relating to this gene ( 261 )
List References by type	Research paper  ( 157 ) Supplementary material  ( 12 ) Review  ( 38 ) Personal communication to FlyBase  ( 15 ) Abstract  ( 24 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 5 ) Conference report  ( 2 ) Stock list  ( 1 ) Website  ( 1 ) Letter  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 32 )
	Okamoto et al., 2013, Genes Dev. 27(1): 87--97 A secreted decoy of InR antagonizes insulin/IGF signaling to restrict body growth in Drosophila. [FBrf0220509] Benmimoun et al., 2012, Development 139(10): 1713--1717 Dual role for Insulin/TOR signaling in the control of hematopoietic progenitor maintenance in Drosophila. [FBrf0218049] Dahlgaard et al., 2012, Proc. Natl. Acad. Sci. U.S.A. 109(18): 6987--6992 Neurofibromatosis-like phenotype in Drosophila caused by lack of glucosylceramide extension. [FBrf0218176] Denton et al., 2012, Cell Death Differ. 19(8): 1299--1307 Relationship between growth arrest and autophagy in midgut programmed cell death in Drosophila. [FBrf0218812] Dragojlovic-Munther and Martinez-Agosto, 2012, Development 139(20): 3752--3763 Multifaceted roles of PTEN and TSC orchestrate growth and differentiation of Drosophila blood progenitors. [FBrf0219482] Gault et al., 2012, J. Cell Biol. 196(5): 605--621 Drosophila CK1-γ, gilgamesh, controls PCP-mediated morphogenesis through regulation of vesicle trafficking. [FBrf0217630] Hafezi et al., 2012, Dev. Biol. 368(2): 358--369 Differences in levels of the transmembrane protein Crumbs can influence cell survival at clonal boundaries. [FBrf0218964] Howell et al., 2012, Immunogenetics 64(2): 155--161 A directed miniscreen for genes involved in the Drosophila anti-parasitoid immune response. [FBrf0217123] Johnson et al., 2012, Genes Brain Behav. 11(7): 848--858 Ras-dependent and Ras-independent effects of PI3K in Drosophila motor neurons. [FBrf0219522] Justiniano et al., 2012, PLoS ONE 7(2): e31417 Loss of the Tumor Suppressor Pten Promotes Proliferation of Drosophila melanogaster Cells In Vitro and Gives Rise to Continuous Cell Lines. [FBrf0217611] Killip and Grewal, 2012, Dev. Biol. 371(2): 191--202 DREF is required for cell and organismal growth in Drosophila and functions downstream of the nutrition/TOR pathway. [FBrf0219592] Kuo et al., 2012, PLoS Genet. 8(4): e1002684 Insulin signaling mediates sexual attractiveness in Drosophila. [FBrf0218255] Marinari et al., 2012, Nature 484(7395): 542--545 Live-cell delamination counterbalances epithelial growth to limit tissue overcrowding. [FBrf0218620] Pircs et al., 2012, PLoS ONE 7(8): e44214 Advantages and Limitations of Different p62-Based Assays for Estimating Autophagic Activity in Drosophila. [FBrf0219364] Song et al., 2012, Genes Dev. 26(14): 1612--1625 Regeneration of Drosophila sensory neuron axons and dendrites is regulated by the Akt pathway involving Pten and microRNA bantam. [FBrf0218927] Tokusumi et al., 2012, PLoS ONE 7(7): e41604 Gene regulatory networks controlling hematopoietic progenitor niche cell production and differentiation in the Drosophila lymph gland. [FBrf0219204] Wang et al., 2012, Nat. Commun. 3: 769 Drosophila follicle stem cells are regulated by proliferation and niche adhesion as well as mitochondria and ROS. [FBrf0217898] Zhai et al., 2012, PLoS Genet. 8(3): e1002582 Antagonistic regulation of apoptosis and differentiation by the cut transcription factor represents a tumor-suppressing mechanism in Drosophila. [FBrf0217859] Cheng et al., 2011, Cell 146(3): 435--447 Anaplastic Lymphoma Kinase Spares Organ Growth during Nutrient Restriction in Drosophila. [FBrf0214599] Djiane et al., 2011, J. Cell Biol. 192(1): 189--200 Su(dx) E3 ubiquitin ligase-dependent and -independent functions of Polychaetoid, the Drosophila ZO-1 homologue. [FBrf0212737] Eddison et al., 2011, Neuron 70(5): 979--990 arouser Reveals a Role for Synapse Number in the Regulation of Ethanol Sensitivity. [FBrf0213908] Friedman et al., 2011, Sci. Signal. 4(196): rs10 Proteomic and functional genomic landscape of receptor tyrosine kinase and ras to extracellular signal-regulated kinase signaling. [FBrf0216513] Horn et al., 2011, Nat. Methods 8(4): 341--346 Mapping of signaling networks through synthetic genetic interaction analysis by RNAi. [FBrf0213352] Lindquist et al., 2011, Genome Res. 21(3): 433--446 Genome-scale RNAi on living-cell microarrays identifies novel regulators of Drosophila melanogaster TORC1-S6K pathway signaling. [FBrf0213199] Nakajima et al., 2011, Mol. Cell. Biol. 31(12): 2499--2512 Nonautonomous Apoptosis Is Triggered by Local Cell Cycle Progression during Epithelial Replacement in Drosophila. [FBrf0213728] Parisi et al., 2011, BMC Biol. 9: 65 Drosophila insulin and target of rapamycin (TOR) pathways regulate GSK3 beta activity to control Myc stability and determine Myc expression in vivo. [FBrf0216934] Park et al., 2011, Cell. Molec. Life Sci. 68(20): 3377--3384 Protein O-GlcNAcylation regulates Drosophila growth through the insulin signaling pathway. [FBrf0216304] Poon et al., 2011, Dev. Cell 21(5): 896--906 The Sterile 20-like Kinase Tao-1 Controls Tissue Growth by Regulating the Salvador-Warts-Hippo Pathway. [FBrf0216620] Resnik-Docampo and de Celis, 2011, PLoS ONE 6(1): e14528 MAP4K3 Is a Component of the TORC1 Signalling Complex that Modulates Cell Growth and Viability in Drosophila melanogaster. [FBrf0212911] Roubinet et al., 2011, J. Cell Biol. 195(1): 99--112 Molecular networks linked by Moesin drive remodeling of the cell cortex during mitosis. [FBrf0216647] Sousa-Nunes et al., 2011, Nature 471(7339): 508--512 Fat cells reactivate quiescent neuroblasts via TOR and glial insulin relays in Drosophila. [FBrf0214426] Tang et al., 2011, PLoS Genet. 7(11): e1002373 FOXO Regulates Organ-Specific Phenotypic Plasticity In Drosophila. [FBrf0216701] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...