HomeGene Dmel\Pten
| General Information | |||
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| Symbol | Dmel\Pten | Species | D. melanogaster |
| Name | Pten | Annotation symbol | CG5671 |
| Feature type | protein_coding_gene | FlyBase ID | FBgn0026379 |
| Created / Updated | 2003-12-22/2003-12-22 | ||
| Genomic Location | |||
| Chromosome (arm) | 2L | Recombination map | |
| Cytogenetic map | 31B1-31B1 | Sequence location | 2L:10,256,318..10,261,017 [-] |
| Map ( GBrowse ) | 
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Summary Information
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Automatically generated summary
See sections below for more information | This gene is referred to in FlyBase by the symbol Pten (CG5671, FBgn0026379). It has the cytological map location 31B1. Its sequence location is 2L:10256318..10261017. Its molecular function is described as: non-membrane spanning protein tyrosine phosphatase activity; phosphoprotein phosphatase activity; protein tyrosine/serine/threonine phosphatase activity; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity; actin binding; protein tyrosine phosphatase activity; protein serine/threonine phosphatase activity; serine-type endopeptidase inhibitor activity. It is involved in the biological processes described with 31 unique terms, many of which group under: regulation of biological process; anatomical structure development; organelle organization and biogenesis; actin filament-based process; negative regulation of growth; cytoskeleton organization and biogenesis; transmembrane receptor protein tyrosine kinase signaling pathway; regulation of multicellular organism growth; regulation of cell size; larval development; organ development. 31 alleles are reported. The phenotypes of these alleles are annotated with 35 unique terms, many of which group under: organ system; peripheral nervous system; nervous system; primordium; extended germ band embryo; adult segment; adult mesothoracic segment; adult; blastoderm embryo; endocrine system. It has 6 annotated transcripts and 6 annotated polypeptides. | ||
| External Summaries | |||
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Detailed Mapping Data
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| FlyBase Computed Cytological Location | |||
Cytogenetic map Evidence for location 31B1-31B1
Limits computationally determined from genome sequence between P{lacW}me31Bk06607 and P{PZ}nmd08774
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| Experimentally Determined Cytological Location | |||
Cytogenetic map Notes References 31B-31C 31C-31D 31A1-31D6 31B-31C (determined by in situ hybridisation)
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| Experimentally Determined Recombination Data | |||
| Location | |||
| Left of (cM) | |||
| Right of (cM) | |||
| Notes | |||
| Molecular Map Data | |||
Gene Order (in direction of increasing cytology)
References In direction of increasing cytology: Ror? Pten? Gene Order (overall orientation not stated) References Overall orientation not stated: Rsf1+ Pten+ | |||
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Gene Model & Products
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Please see the
GBrowse view of
Dmel\Pten
for information on other features
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| Comments on Gene Model | |||
EST data support existence of multiple transcripts Multiphase exon postulated: variable use of small exons; supported exon combinations result in frameshift and premature stop in downstream exon in some transcripts. DGC clone LP04865 appears problematic: incomplete CDS | |||
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Transcript Data
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| Annotated Transcripts | |||
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) | |||
| Additional Transcript Data & Comments | |||
| Reported size (kB) | 1.872 (longest cDNA) | ||
| Comments | |||
| External Data | |||
| Crossreferences | |||
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Polypeptide Data
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| Annotated Polypeptides | |||
Name FlyBase ID
Predicted MW (kD)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
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| Additional Polypeptide Data & Comments | |||
| Reported size (kD) | 514 (aa) 514, 509 (aa) 511, 509, 418 (aa) | ||
| Comments | |||
| External Data | |||
| Linkouts | PANTHER
- Protein classification by function, families, and pathways
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| Crossreferences | InterPro
domains - A database of protein families, domains, and functional sites
• Protease inhibitor I4, serpin (IPR000215)
Protein-tyrosine phosphatase, dual specificity (IPR000340)
Protein-tyrosine phosphatase (IPR000387)
C2 calcium/lipid-binding region, CaLB (IPR008973)
Phosphatase tensin type (IPR014019)
C2 tensin-type (IPR014020)
Protein-tyrosine phosphatase, active site (IPR016130)
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Sequences Consistent with the Gene Model
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| DDBJ
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EMBL / GenBank | DNA sequence Protein sequence Name | ||
| UniProtKB/Swiss-Prot | |||
| UniProtKB/TrEMBL | |||
| Maps to | |||
| Does NOT map to | |||
| Identified with | |||
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Mapped Features & Mutations
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Please see
GBrowse
or insertion reports for information on insertions of transgenic
constructs and features not listed here
Type Symbol & Location Additional Notes References point mutation Pten[c494] 2L:10,259,043..10,259,043 comment=Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. evidence=experimental na_change=G10259043A pr_change=G135E|Pten-PD,G135E|Pten-PE,G135E|Pten-PB,G135 E|Pten-PA,G135E|Pten-PC,G135E|Pten-PF reported_pr_change=G135E rescue fragment Pten[+t6.2] 2L:10,256,223..10,262,525 comment=position of restriction fragment on reference sequence inferred by FlyBase curator evidence=experimental linked_to=SpeI-SpeI_rfrag rescue fragment Pten[+t6] 2L:10,256,262..10,262,450 comment=Extent of rescue fragment provided by author in a personal communication to FlyBase. evidence=experimental rescue fragment Pten[+t6.3] 2L:10,255,830..10,262,130 comment=6.3kb genomic NotI-SalI fragment; NotI is vector derived. 5' end of fragment inferred by Flybase annotator. evidence=experimental linked_to=START-SalI_rfrag sequence variant Pten-misc_feature-24 2L:10,257,510..10,257,518 comment=polymorphic region deleted in some genomic and cDNA clones evidence=experimental | |||
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External Data
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| Linkouts | DEDB
- Drosophila exon database: splicing graphs
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| Crossreferences | |||
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Expression Data
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| FlyBase-Curated Data | |||
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Transcript and Protein data | Please see the FlyBase Gene Expression Report for details of gene expression from the literature. | ||
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Summary of Transcript Expression
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Stage Tissue/Position
Reference
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| Marker for | |||
| Subcellular Localization | |||
| CV Term | |||
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Summary of Polypeptide Expression
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Stage Tissue/Position
Reference
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| Marker for | |||
| Subcellular Localization | |||
| CV Term | |||
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External Data & Images
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| Linkouts | FLIGHT
- Cell culture data for RNAi and other high-throughput technologies
FlyAtlas
- Adult expression by tissue, using Affymetrix Dros2 array
GEO (NCBI)
- Gene expression data: microarray and other high-throughput technologies
FlyExpress
- Embryonic expression images (BDGP data)
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Alleles & Phenotypes
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Summary of Allele Phenotypes
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Lethality Allele Other Phenotypes Allele large body (with Pten117) large body (with Pten2L100) Phenotype manifest in Allele lipid particle & nurse cell | somatic clone wing & cell, with Scer\GAL4dpp.blk1 lipid droplet & larval oenocyte, with Scer\GAL4ppl.PP nurse cell & actin cytoskeleton | germ-line clone | |||
Stage(s)
1-3
Stage(s)
4-6
Stage(s)
9-10
Stage(s)
11-12
Stage(s)
13-16