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Gene Dmel\Pten

General Information
Symbol	Dmel\Pten	Species	D. melanogaster
Name	Pten	Annotation symbol	CG5671
Feature type	protein_coding_gene	FlyBase ID	FBgn0026379
Gene Model Status	Current	Stock availability	10 publicly available
Also Known As	dPTEN
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	31B1-31B1	Sequence location	2L:10,256,319..10,261,017 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Pten is referred to in FlyBase by the symbol Dmel\Pten (CG5671, FBgn0026379). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: phosphoprotein phosphatase activity; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity; protein serine/threonine phosphatase activity. There is experimental evidence for 26 unique biological process terms, many of which group under: biological regulation; cellular component organization or biogenesis; organelle organization; actin filament-based process; regulation of developmental process; cellular process; cell proliferation; macromolecule modification; programmed cell death; localization; response to nutrient levels; gland morphogenesis; open tracheal system development; catabolic process; metamorphosis. 39 alleles are reported. The phenotypes of these alleles are annotated with: organ system; organ system subdivision; external compound sense organ; adult segment; peripheral nervous system; thoracic segment; imaginal precursor; adult; embryonic/larval corpus allatum; embryonic/larval fat body; cell part; cell cycle. It has 7 annotated transcripts and 7 annotated polypeptides. Protein features are: Bifunctional phosphatidylinositol trisphosphate phosphatase/dual-specificity phosphatase PTEN; C2 calcium/lipid-binding domain, CaLB; Dual specificity phosphatase, catalytic domain; Phosphatase tensin type; Protein-tyrosine phosphatase, active site; Tensin phosphatase, C2 domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of low expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult crop, larval salivary gland, adult female reproductive system, adult testis. Gene sequence location is 2L:10256319..10261017.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01	References Poon et al., 2011, Dev. Cell 21(5): 896--906 Roubinet et al., 2011, J. Cell Biol. 195(1): 99--112 Yin et al., 2008, BMC Bioinformatics 9: 264 Sequence features BKN29278 HFA03402 BKN60626 BKN60562
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 31B1-31B1   Limits computationally determined from genome sequence between P{lacW}me31Bk06607 and P{PZ}nmd08774
Experimentally Determined Cytological Location
Cytogenetic map Notes References 31B-31C     (Goberdhan, 1999.11.4) 31C-31D     (Tao, 1999.4.19) 31A1-31D6     (Smith, 1999.6.23) 31B-31C   (determined by in situ hybridisation)   (Wilson, 1999.3.4)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Pten for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Alternative translation stop created by use of multiphasic reading frames within coding region.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Pten-RA FBtr0089905  NM_134320   2536   509 Pten-RB FBtr0089904  NM_058075   2323   514 Pten-RC FBtr0089902  NM_058076   1814   418 Pten-RD FBtr0089900  NM_134322   2136   514 Pten-RE FBtr0089901  NM_134321   2349   509 Pten-RG FBtr0300562  NM_001169462   2546   514 Pten-RH FBtr0301521  NM_058074   2435   514
Additional Transcript Data & Comments
Reported size (kB)	1.872 (longest cDNA) (Huang et al., 1999)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Pten-PA   FBpp0088844   58.4   509   7.25     NP_599147   AAF52887 Pten-PB   FBpp0088843   59.0   514   7.25     NP_477423   AAN10731 Pten-PC   FBpp0088841   48.1   418   7.23     NP_477424   AAN10730 Pten-PD   FBpp0088839   59.0   514   7.25     NP_599149   AAF52888 Pten-PE   FBpp0088840   58.4   509   7.25     NP_599148   AAF52889 Pten-PG   FBpp0289789   59.0   514   7.25     NP_001162933   ACZ94222 Pten-PH   FBpp0290736   59.0   514   7.25     NP_477422   AAN10732
Additional Polypeptide Data & Comments
Reported size (kDa)	514 (aa) (Huang et al., 1999) 514, 509 (aa) (Goberdhan et al., 1999) 511, 509, 418 (aa) (Smith et al., 1999)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Dual specificity phosphatase, catalytic domain (IPR000340) C2 calcium/lipid-binding domain, CaLB (IPR008973) Phosphatase tensin type (IPR014019) Tensin phosphatase, C2 domain (IPR014020) Protein-tyrosine phosphatase, active site (IPR016130) Bifunctional phosphatidylinositol trisphosphate phosphatase/dual-specificity phosphatase PTEN (IPR017361)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014134 AAF52887   AE014134 AAF52888   AE014134 AAF52889   AE014134 AAN10730   AE014134 AAN10731   AE014134 AAN10732   AC005454   AC009849   AE014134 ACZ94222   AF144232 AAF08382   AF161257 AAD45362   AF161258 AAD45363   AF161259 AAD45364   AF201904 AAF23235   AF201905 AAF23236   AF201906 AAF23237   AF201907 AAF23238   AI260874   BE977468   BI165965   BI166802   BI214358   BI243738   BI363888   BI365447   BI481544   BI483179   BQ102888   BT025053   CO187855   CO264295   CO265048   CO275349   CO297781   CO298023   CO300933   CO306518   CO307634   CO316575   CO320748   EC062676   EC073976   EC083619   EC084234   EC087905   EC090071   EC213739   EC221290   EC238057   EC238728   EC245536   EC249846   EL884903   EL885023   EL885024   EL885148   EL885149   EV590572
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7KJN5 Q7KJN6 Q9U470 Q9V3L4 Q9Y0B5 Q9Y0B6 Q7KMQ6
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References sequence variant Pten-misc_feature-24 2L:10,257,510..10,257,518 comment=polymorphic region deleted in some genomic and cDNA clones evidence=experimental (Goberdhan et al., 1999)
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0026379    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0026379 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of low expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0026379 expression level Developmental Stage   Expression Level embryo 00-02hr    1131 embryo 02-04hr    698 embryo 04-06hr    1159 embryo 06-08hr    905 embryo 08-10hr    985 embryo 10-12hr    572 embryo 12-14hr    1182 embryo 14-16hr    259 embryo 16-18hr    480 embryo 18-20hr    263 embryo 20-22hr    286 embryo 22-24hr    562 larva L1    264 larva L2    292 larva L3 12hr old    205 larva L3 puffstage 1-2    228 larva L3 puffstage 3-6    334 larva L3 puffstage 7-9    804 white prepupae new    839 white prepupae 12hr    857 white prepupae 24hr    920 pupae 2d postWPP    862 pupae 3d postWPP    551 pupae 4d postWPP    182 adult male 01day    353 adult male 05day    308 adult male 30day    224 adult female 01day    287 adult female 05day    1086 adult female 30day    664 Expression Level Scale  None   Extremely low   Very low   Low   Moderate  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1131) embryo 02-04hr  (698) embryo 04-06hr  (1159) embryo 06-08hr  (905) embryo 08-10hr  (985) embryo 10-12hr  (572) embryo 12-14hr  (1182) embryo 14-16hr  (259) embryo 16-18hr  (480) embryo 18-20hr  (263) embryo 20-22hr  (286) embryo 22-24hr  (562) larva L1  (264) larva L2  (292) larva L3 12hr old  (205) larva L3 puffstage 1-2  (228) larva L3 puffstage 3-6  (334) larva L3 puffstage 7-9  (804) white prepupae new  (839) white prepupae 12hr  (857) white prepupae 24hr  (920) pupae 2d postWPP  (862) pupae 3d postWPP  (551) pupae 4d postWPP  (182) adult male 01day  (353) adult male 05day  (308) adult male 30day  (224) adult female 01day  (287) adult female 05day  (1086) adult female 30day  (664) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1131 embryo 02-04hr    698 embryo 04-06hr    1159 embryo 06-08hr    905 embryo 08-10hr    985 embryo 10-12hr    572 embryo 12-14hr    1182 embryo 14-16hr    259 embryo 16-18hr    480 embryo 18-20hr    263 embryo 20-22hr    286 embryo 22-24hr    562 larva L1    264 larva L2    292 larva L3 12hr old    205 larva L3 puffstage 1-2    228 larva L3 puffstage 3-6    334 larva L3 puffstage 7-9    804 white prepupae new    839 white prepupae 12hr    857 white prepupae 24hr    920 pupae 2d postWPP    862 pupae 3d postWPP    551 pupae 4d postWPP    182 adult male 01day    353 adult male 05day    308 adult male 30day    224 adult female 01day    287 adult female 05day    1086 adult female 30day    664 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1131 embryo 02-04hr    698 embryo 04-06hr    1159 embryo 06-08hr    905 embryo 08-10hr    985 embryo 10-12hr    572 embryo 12-14hr    1182 embryo 14-16hr    259 embryo 16-18hr    480 embryo 18-20hr    263 embryo 20-22hr    286 embryo 22-24hr    562 larva L1    264 larva L2    292 larva L3 12hr old    205 larva L3 puffstage 1-2    228 larva L3 puffstage 3-6    334 larva L3 puffstage 7-9    804 white prepupae new    839 white prepupae 12hr    857 white prepupae 24hr    920 pupae 2d postWPP    862 pupae 3d postWPP    551 pupae 4d postWPP    182 adult male 01day    353 adult male 05day    308 adult male 30day    224 adult female 01day    287 adult female 05day    1086 adult female 30day    664 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1131 embryo 02-04hr    698 embryo 04-06hr    1159 embryo 06-08hr    905 embryo 08-10hr    985 embryo 10-12hr    572 embryo 12-14hr    1182 embryo 14-16hr    259 embryo 16-18hr    480 embryo 18-20hr    263 embryo 20-22hr    286 embryo 22-24hr    562 larva L1    264 larva L2    292 larva L3 12hr old    205 larva L3 puffstage 1-2    228 larva L3 puffstage 3-6    334 larva L3 puffstage 7-9    804 white prepupae new    839 white prepupae 12hr    857 white prepupae 24hr    920 pupae 2d postWPP    862 pupae 3d postWPP    551 pupae 4d postWPP    182 adult male 01day    353 adult male 05day    308 adult male 30day    224 adult female 01day    287 adult female 05day    1086 adult female 30day    664 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0026379 expression level Developmental Stage   Expression Level embryo 00-02hr    1131 embryo 02-04hr    698 embryo 04-06hr    1159 embryo 06-08hr    905 embryo 08-10hr    985 embryo 10-12hr    572 embryo 12-14hr    1182 embryo 14-16hr    259 embryo 16-18hr    480 embryo 18-20hr    263 embryo 20-22hr    286 embryo 22-24hr    562 larva L1    264 larva L2    292 larva L3 12hr old    205 larva L3 puffstage 1-2    228 larva L3 puffstage 3-6    334 larva L3 puffstage 7-9    804 white prepupae new    839 white prepupae 12hr    857 white prepupae 24hr    920 pupae 2d postWPP    862 pupae 3d postWPP    551 pupae 4d postWPP    182 adult male 01day    353 adult male 05day    308 adult male 30day    224 adult female 01day    287 adult female 05day    1086 adult female 30day    664 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1131) embryo 02-04hr  (698) embryo 04-06hr  (1159) embryo 06-08hr  (905) embryo 08-10hr  (985) embryo 10-12hr  (572) embryo 12-14hr  (1182) embryo 14-16hr  (259) embryo 16-18hr  (480) embryo 18-20hr  (263) embryo 20-22hr  (286) embryo 22-24hr  (562) larva L1  (264) larva L2  (292) larva L3 12hr old  (205) larva L3 puffstage 1-2  (228) larva L3 puffstage 3-6  (334) larva L3 puffstage 7-9  (804) white prepupae new  (839) white prepupae 12hr  (857) white prepupae 24hr  (920) pupae 2d postWPP  (862) pupae 3d postWPP  (551) pupae 4d postWPP  (182) adult male 01day  (353) adult male 05day  (308) adult male 30day  (224) adult female 01day  (287) adult female 05day  (1086) adult female 30day  (664) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1131 embryo 02-04hr    698 embryo 04-06hr    1159 embryo 06-08hr    905 embryo 08-10hr    985 embryo 10-12hr    572 embryo 12-14hr    1182 embryo 14-16hr    259 embryo 16-18hr    480 embryo 18-20hr    263 embryo 20-22hr    286 embryo 22-24hr    562 larva L1    264 larva L2    292 larva L3 12hr old    205 larva L3 puffstage 1-2    228 larva L3 puffstage 3-6    334 larva L3 puffstage 7-9    804 white prepupae new    839 white prepupae 12hr    857 white prepupae 24hr    920 pupae 2d postWPP    862 pupae 3d postWPP    551 pupae 4d postWPP    182 adult male 01day    353 adult male 05day    308 adult male 30day    224 adult female 01day    287 adult female 05day    1086 adult female 30day    664 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1131 embryo 02-04hr    698 embryo 04-06hr    1159 embryo 06-08hr    905 embryo 08-10hr    985 embryo 10-12hr    572 embryo 12-14hr    1182 embryo 14-16hr    259 embryo 16-18hr    480 embryo 18-20hr    263 embryo 20-22hr    286 embryo 22-24hr    562 larva L1    264 larva L2    292 larva L3 12hr old    205 larva L3 puffstage 1-2    228 larva L3 puffstage 3-6    334 larva L3 puffstage 7-9    804 white prepupae new    839 white prepupae 12hr    857 white prepupae 24hr    920 pupae 2d postWPP    862 pupae 3d postWPP    551 pupae 4d postWPP    182 adult male 01day    353 adult male 05day    308 adult male 30day    224 adult female 01day    287 adult female 05day    1086 adult female 30day    664 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1131 embryo 02-04hr    698 embryo 04-06hr    1159 embryo 06-08hr    905 embryo 08-10hr    985 embryo 10-12hr    572 embryo 12-14hr    1182 embryo 14-16hr    259 embryo 16-18hr    480 embryo 18-20hr    263 embryo 20-22hr    286 embryo 22-24hr    562 larva L1    264 larva L2    292 larva L3 12hr old    205 larva L3 puffstage 1-2    228 larva L3 puffstage 3-6    334 larva L3 puffstage 7-9    804 white prepupae new    839 white prepupae 12hr    857 white prepupae 24hr    920 pupae 2d postWPP    862 pupae 3d postWPP    551 pupae 4d postWPP    182 adult male 01day    353 adult male 05day    308 adult male 30day    224 adult female 01day    287 adult female 05day    1086 adult female 30day    664 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0026379    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0026379 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult crop, larval salivary gland, adult female reproductive system, adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Heatmap Tissue   Expression Level Larval Central Nervous System no informative data Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary no informative data Adult Testis no informative data Adult Male Accessory Gland no informative data Adult Carcass no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_05
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0026379 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5671-RC;CG5671-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Pten Stages(s) 1-3 Stages(s) 4-6 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4arm.PS PtenScer\UAS.cGb lethal, with Scer\GAL4ey.PH PtenScer\UAS.cKa lethal | first instar larval stage, with Scer\GAL4phm.PO PtenScer\UAS.cGb lethal | larval stage | recessive Ptenunspecified lethal | late third instar larval stage (with Df(2L)flp170B) Pten3 lethal | partially | pupal stage, with Scer\GAL4P0206 PtenScer\UAS.cGb lethal | recessive Pten1 Pten3 Ptenc494 semi-lethal, with Scer\GAL4en-e16E PtenScer\UAS.cGa semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 PtenGD13500 viable Pten2L100 viable, with Scer\GAL4Scer\UAS.cHa, Scer\GAL4tin.cBa PtenScer\UAS.cGb Other Phenotypes Allele aging defective, with Scer\GAL4Mhc.PW PtenScer\UAS.cHa aging defective, with Scer\GAL4Scer\UAS.cHa, Scer\GAL4tin.cBa PtenScer\UAS.cGb chemical resistant, with Scer\GAL4elav-C155 PtenScer\UAS.cGb chemical resistant | adult stage | heat sensitive, with Scer\GAL4elav-C155, Scer\GAL80ts.αTub84B PtenScer\UAS.cGb decreased cell number, with Scer\GAL4ap-md544 PtenScer\UAS.cGb decreased cell number, with Scer\GAL4Bx-MS1096 PtenScer\UAS.cGb decreased cell number, with Scer\GAL4en-e16E PtenScer\UAS.cGb decreased cell size, with Scer\GAL4ap-md544 PtenScer\UAS.cGb decreased cell size, with Scer\GAL4Bx-MS1096 PtenScer\UAS.cGb decreased cell size, with Scer\GAL4en-e16E PtenScer\UAS.cGb decreased cell size, with Scer\GAL4ppl.PP PtenScer\UAS.cHa decreased cell size | somatic clone, with Scer\GAL4Act5C.PP PtenScer\UAS.cGb developmental rate defective | second instar larval stage, with Scer\GAL4P0206 PtenScer\UAS.cGb developmental rate defective | third instar larval stage, with Scer\GAL4P0206 PtenScer\UAS.cGb hyperplasia | somatic clone Pten1 Pten3 increased cell number, with Scer\GAL4nub-AC-62 PtenGD13500 increased cell number (with Pten2L100) Pten117 increased cell number (with Pten117) Pten2L100 increased cell number | recessive | somatic clone Pten117 increased cell number | somatic clone Ptendj189 increased cell size (with Pten2L100) Pten117 increased cell size (with Pten117) Pten2L100 increased cell size | recessive | somatic clone Pten1 Pten117 increased cell size | somatic clone Pten117 Ptendj189 large body (with Pten2L100) Pten117 large body (with Pten117) Pten2L100 large body | pharate adult stage, with Scer\GAL4P0206 PtenScer\UAS.cGb large body | recessive | somatic clone Pten1 Pten117 large body | second instar larval stage, with Scer\GAL4P0206 PtenScer\UAS.cGb large body | somatic clone Pten117 long lived, with Scer\GAL4Mhc.PW PtenScer\UAS.cHa long lived | RU486 conditional, with Scer\GAL4bun-Switch1.32 PtenScer\UAS.cGb neuroanatomy defective | larval stage, with Scer\GAL4C57 Ptendj189 PtendsRNA.Exel.Scer\UAS neuroanatomy defective | larval stage, with Scer\GAL4ppk.PG PtenScer\UAS.cHa neurophysiology defective | larval stage, with Ptendj189, Scer\GAL4C57 PtendsRNA.Exel.Scer\UAS neurophysiology defective | larval stage, with PtendsRNA.Exel.Scer\UAS, Scer\GAL4C57 Ptendj189 planar polarity defective | recessive | somatic clone Pten1 short lived | RU486 conditional, with Scer\GAL4elav.Switch.PO PtenScer\UAS.cGb size defective, with Scer\GAL4nub-AC-62 PtenGD13500 small body, with Scer\GAL4arm.PS PtenScer\UAS.cGb stress response defective (with Pten2L100) Pten117 stress response defective (with Pten117) Pten2L100 visible, with Scer\GAL4ap-md544 PtenScer\UAS.cGa visible, with Scer\GAL4ci.PU PtenScer\UAS.cGa visible, with Scer\GAL4ey.PH PtenScer\UAS.cGb PtenScer\UAS.cHa PtenScer\UAS.cKa PtenScer\UAS.cSa visible, with Scer\GAL4GMR.PF PtenScer\UAS.cHa PtenScer\UAS.cKa visible, with Scer\GAL4pnr-MD237 PtenGD13500 visible, with Scer\GAL4salm.PU PtenScer\UAS.cGa visible | first instar larval stage, with Scer\GAL4hs.PB PtenScer\UAS.cSa visible | recessive | somatic clone Pten117 visible | somatic clone Pten117 Ptenc494 Ptenunspecified wild-type Pten+t6.2 Pten+t6.3 Ptenhs.PG wild-type | RU486 conditional, with Scer\GAL4Switch1.106 PtenScer\UAS.cGb Phenotype manifest in Allele abdominal tracheal primordium 1 | germline clone | maternal effect Ptenc494 abdominal tracheal primordium 2 | germline clone | maternal effect Ptenc494 adult head Pten117 adult head | somatic clone Pten117 adult heart, with Scer\GAL4Scer\UAS.cHa, Scer\GAL4tin.cBa PtenScer\UAS.cGb blastoderm embryo | germline clone | maternal effect Ptendj189 cell cycle, with Scer\GAL4ey.PH PtenScer\UAS.cHa chaeta | supernumerary, with Scer\GAL4pnr-MD237 PtenGD13500 cleavage stage embryo | germline clone | maternal effect Ptendj189 crossvein | somatic clone Pten1 Pten3 dendrite | larval stage, with Scer\GAL4ppk.PG PtenScer\UAS.cHa egg | germline clone | maternal effect Ptendj189 egg | maternal effect Ptenc494 embryonic/first instar larval cuticle | first instar larval stage, with Scer\GAL4hs.PB PtenScer\UAS.cSa embryonic/larval corpus allatum, with Scer\GAL4P0206 PtenScer\UAS.cGb embryonic/larval fat body, with Scer\GAL4ppl.PP PtenScer\UAS.cHa embryonic/larval fat body | somatic clone, with Scer\GAL4Act5C.PP PtenScer\UAS.cGb embryonic/larval neuroblast, with Scer\GAL4nab PtenScer\UAS.cHa embryonic/larval salivary gland, with Scer\GAL429BD PtenScer\UAS.cGb embryonic/larval salivary gland | somatic clone, with Scer\GAL4Act5C.PP PtenScer\UAS.cGb eye, with Scer\GAL4ey.PH PtenScer\UAS.cGb PtenScer\UAS.cHa PtenScer\UAS.cSa eye, with Scer\GAL4GMR.PF PtenScer\UAS.cGb PtenScer\UAS.cHa PtenScer\UAS.cKa eye | somatic clone Pten1 Pten117 Pten3 Ptendj189 Ptenunspecified eye disc, with Scer\GAL4ey.PH PtenScer\UAS.cHa eye disc, with Scer\GAL4GMR.PF PtenScer\UAS.cHa eye disc | somatic clone Pten1 Ptendj189 eye photoreceptor cell, with Scer\GAL4GMR.PF PtenScer\UAS.cHa eye photoreceptor cell | somatic clone Pten1 Ptendj189 fat body, with Scer\GAL4Lsp2.PH PtenScer\UAS.cGb gastrula embryo | germline clone | maternal effect Ptendj189 head capsule | somatic clone Pten117 interommatidial bristle | somatic clone Pten1 Pten3 Ptendj189 lens, with Scer\GAL4GMR.PF PtenScer\UAS.cHa lipid droplet & larval oenocyte, with Scer\GAL4ppl.PP PtenScer\UAS.cHa lipid particle & nurse cell | somatic clone Pten1 mesothoracic tergum, with Scer\GAL4pnr-MD237 PtenGD13500 mesothoracic tracheal primordium | germline clone | maternal effect Ptenc494 metathoracic tracheal primordium | germline clone | maternal effect Ptenc494 muscle cell, with Scer\GAL4Mhc.PW PtenScer\UAS.cHa NMJ bouton, with Ptendj189, Scer\GAL4C57 PtendsRNA.Exel.Scer\UAS NMJ bouton, with PtendsRNA.Exel.Scer\UAS, Scer\GAL4C57 Ptendj189 NMJ bouton, with Scer\GAL4C57 PtendsRNA.Exel.Scer\UAS nurse cell & actin cytoskeleton | germ-line clone Ptendj189 nurse cell & nucleus | germ-line clone Ptendj189 nurse cell | germline clone Ptendj189 ommatidial precursor cluster | somatic clone Pten1 ommatidium, with Scer\GAL4ey.PH PtenScer\UAS.cHa ommatidium, with Scer\GAL4GMR.PF PtenScer\UAS.cGb PtenScer\UAS.cHa ommatidium | somatic clone Pten1 Pten117 Pten3 Ptenc494 Ptendj189 photoreceptor cell | cell autonomous | somatic clone Pten1 Pten3 photoreceptor cell | somatic clone Ptenc494 pigment cell, with Scer\GAL4GMR.PF PtenScer\UAS.cHa pole cell | germline clone | maternal effect Ptendj189 prothoracic gland, with Scer\GAL4P0206 PtenScer\UAS.cGb puparium, with Scer\GAL4P0206 PtenScer\UAS.cGb rhabdomere, with Scer\GAL4GMR.PF PtenScer\UAS.cHa rhabdomere | cell autonomous | somatic clone Pten1 Pten3 rhabdomere | somatic clone Pten1 tracheal primordium | ectopic | germline clone | maternal effect Ptenc494 tracheal primordium | germline clone | maternal effect Ptenc494 wing, with Scer\GAL4Bx-MS1096 PtenScer\UAS.cGb wing, with Scer\GAL4ci.PU PtenScer\UAS.cGa wing, with Scer\GAL4en-e16E PtenScer\UAS.cGa wing, with Scer\GAL4nub-AC-62 PtenGD13500 wing, with Scer\GAL4P0206 PtenScer\UAS.cGb wing, with Scer\GAL4salm.PU PtenScer\UAS.cGa wing & cell, with Scer\GAL4dpp.blk1 PtenScer\UAS.cGa wing & cell | somatic clone Pten1 Pten3 wing | dorsal compartment, with Scer\GAL4ap-md544 PtenScer\UAS.cGb wing | posterior compartment, with Scer\GAL4en-e16E PtenScer\UAS.cGa PtenScer\UAS.cGb wing | somatic clone Pten1 Pten3 wing blade, with Scer\GAL4ap-md544 PtenScer\UAS.cGa wing disc Ptenunspecified wing hair | ectopic | somatic clone Pten1 Pten3 wing margin bristle | somatic clone Ptendj189
Classical Alleles ( 11 )
For All Classical Alleles Show
Allele of Pten Class Mutagen Stocks Known lesion PtenC076 1 -- Ptenf04844 1 -- Pten117 loss of function allele 0 Yes Pten1 ethyl methanesulfonate 0 -- Pten2L100 hypomorphic allele - genetic evidence 0 Yes Pten3 ethyl methanesulfonate 0 -- Ptenc494 loss of function allele ethyl methanesulfonate 0 Yes Ptendj189 0 Yes PtenMGH1 ethyl methanesulfonate 0 -- Ptenmgh3 0 -- Ptenunspecified 0 --
Alleles Carried on Transgenic Constructs ( 28 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Pten Class Mutagen Stocks Known lesion PtendsRNA.Exel.Scer\UAS in vitro construct - RNAi in vitro construct - regulatory fusion 3 Yes PtenGD13500 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes PtenHMS00044 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes PtenJF01859 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes PtenJF01987 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes PtenKK109278 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Pten+t6.2 in vitro construct - genomic fragment 0 Yes Pten+t6.3 in vitro construct - genomic fragment 0 Yes Pten+t6 in vitro construct - genomic fragment 0 Yes Pten1.Act5C.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Pten2.Act5C.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Pten2.cvSa in vitro construct 0 Yes Pten2.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Pten3.Act5C.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Pten3.cvSa in vitro construct 0 Yes Pten3.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Ptena.cRa in vitro construct - RNAi 0 Yes PtencRa in vitro construct - RNAi 0 Yes PtendsRNA.cCa in vitro construct - RNAi 0 Yes PtendsRNA.cGa in vitro construct - RNAi 0 Yes PtendsRNA.cPa in vitro construct - RNAi 0 Yes PtendsRNA.cSa in vitro construct - RNAi 0 Yes Ptenhs.PG in vitro construct - regulatory fusion 0 Yes PtenScer\UAS.cGa in vitro construct - regulatory fusion 0 Yes PtenScer\UAS.cGb in vitro construct - regulatory fusion 0 -- PtenScer\UAS.cHa in vitro construct - regulatory fusion 0 Yes PtenScer\UAS.cKa in vitro construct - regulatory fusion 0 Yes PtenScer\UAS.cSa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel6026 (Ryder, 2004.4.26) Df(2L)flp170B (Goberdhan et al., 1999) Df(2L)J1 (Huang et al., 1999)
Not disrupted in	Df(2L)41C (Goberdhan et al., 1999) Df(2L)flp147E (Goberdhan et al., 1999)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data heat-shock construct P{hs-Pten.G} NA UAS construct P{GD13500} NA P{KK109278} NA P{TRiP.HMS00044} NA P{TRiP.JF01859} NA P{TRiP.JF01987} NA P{UAS-Pten.2.GFP} NA P{UAS-Pten.3.GFP} NA P{UAS-Pten.dsRNA.Exel} NA P{UAS-Pten.G} NA P{UAS-Pten.Gb} NA P{UAS-Pten.H} NA P{UAS-Pten.K} NA P{UAS-Pten.S} NA characterization construct P{Pten.6.2} NA P{Pten.6.3.vivI} NA P{Pten.6} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions F{}Ptendj189 NA PBac{3HPy+}PtenC076 NA PBac{WH}Ptenf04844 NA
Gene Ontology: Function, Process & Cellular Component ( 49 unique terms )
Terms Based on Experimental Evidence ( 29 terms )
Molecular Function
CV term Evidence References
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity inferred from genetic interaction with Pi3K92E AND inferred from sequence or structural similarity with human PTEN (Goberdhan et al., 1999) phosphoprotein phosphatase activity inferred from mutant phenotype (Huang et al., 1999) protein serine/threonine phosphatase activity inferred from mutant phenotype (Gao et al., 2005)
Biological Process
CV term Evidence References
actin cytoskeleton organization inferred from mutant phenotype (von Stein et al., 2005) actin filament organization inferred from mutant phenotype (Kiger et al., 2003) apoptotic process inferred from mutant phenotype (Huang et al., 1999) autophagy inferred from mutant phenotype (Rusten et al., 2004) cell adhesion inferred from mutant phenotype (Kiger et al., 2003) cell proliferation inferred from mutant phenotype (Goberdhan et al., 1999, Gao et al., 2000) cellular process inferred from mutant phenotype (Gao et al., 2000) cytoskeleton organization inferred from mutant phenotype (Goberdhan et al., 1999) epithelial cell fate determination, open tracheal system inferred from mutant phenotype (Jin et al., 2001) insulin receptor signaling pathway inferred from genetic interaction with Pi3K92E AND inferred from genetic interaction with chico (Huang et al., 1999) larval development inferred from mutant phenotype (Mirth et al., 2005) larval salivary gland morphogenesis inferred from mutant phenotype (Takeo et al., 2005) lipid metabolic process inferred from mutant phenotype (Gutierrez et al., 2007) lipid storage inferred from mutant phenotype (Vereshchagina and Wilson, 2006) metamorphosis inferred from mutant phenotype (Mirth et al., 2005) negative regulation of multicellular organism growth inferred from mutant phenotype (Oldham et al., 2002) negative regulation of organ growth inferred from mutant phenotype (Scanga et al., 2000) organ morphogenesis inferred from mutant phenotype (Gao et al., 2000) protein dephosphorylation inferred from mutant phenotype (Gao et al., 2005) regulation of cell shape inferred from mutant phenotype (Goberdhan et al., 1999, Kiger et al., 2003) regulation of cell size inferred from mutant phenotype (Huang et al., 1999, Goberdhan et al., 1999) regulation of dendrite development inferred from mutant phenotype (Parrish et al., 2009) regulation of multicellular organism growth inferred from mutant phenotype (Mirth et al., 2005) response to starvation inferred from mutant phenotype (Oldham et al., 2002) rhabdomere development inferred from mutant phenotype (Pinal et al., 2006) tissue development inferred from mutant phenotype (Gao et al., 2000)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 27 terms )
Molecular Function
CV term Evidence References
actin binding inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000) magnesium ion binding inferred from electronic annotation with InterPro:IPR017361 (FlyBase Curators et al., 2004-) non-membrane spanning protein tyrosine phosphatase activity inferred from sequence or structural similarity (Huang et al., 1999) PDZ domain binding inferred from electronic annotation with InterPro:IPR017361 (FlyBase Curators et al., 2004-) phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity inferred from electronic annotation with InterPro:IPR017361 (FlyBase Curators et al., 2004-) phosphoprotein phosphatase activity inferred from sequence or structural similarity with human PTEN (Goberdhan et al., 1999) protein tyrosine/serine/threonine phosphatase activity inferred from electronic annotation with InterPro:IPR000340 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Huang et al., 1999) non-traceable author statement (Morrison et al., 2000) protein tyrosine phosphatase activity inferred from sequence or structural similarity with human PTEN (Mi et al., 2001.12.13)
Biological Process
CV term Evidence References
apoptotic process traceable author statement (Claeys et al., 2002) inositol phosphate dephosphorylation inferred from electronic annotation with InterPro:IPR017361 (FlyBase Curators et al., 2004-) insulin receptor signaling pathway non-traceable author statement (Johnston and Gallant, 2002) negative regulation of cell cycle traceable author statement (Claeys et al., 2002) negative regulation of cell growth non-traceable author statement (Johnston and Gallant, 2002) negative regulation of cell migration inferred from electronic annotation with InterPro:IPR017361 (FlyBase Curators et al., 2004-) negative regulation of cell proliferation inferred from electronic annotation with InterPro:IPR017361 (FlyBase Curators et al., 2004-) negative regulation of cell size traceable author statement (Weinkove and Leevers, 2000, Potter and Xu, 2001) negative regulation of focal adhesion assembly inferred from electronic annotation with InterPro:IPR017361 (FlyBase Curators et al., 2004-) negative regulation of growth traceable author statement (Oldham and Hafen, 2003) negative regulation of insulin receptor signaling pathway non-traceable author statement (Claeys et al., 2002) traceable author statement (Oldham et al., 2000, Potter and Xu, 2001) negative regulation of organ growth non-traceable author statement (Weinkove and Leevers, 2000) traceable author statement (Oldham et al., 2000, Potter and Xu, 2001) negative regulation of protein kinase B signaling cascade inferred from electronic annotation with InterPro:IPR017361 (FlyBase Curators et al., 2004-) phosphatidylinositol dephosphorylation inferred from electronic annotation with InterPro:IPR017361 (FlyBase Curators et al., 2004-) non-traceable author statement (Oldham and Hafen, 2003) traceable author statement (Oldham et al., 2000) protein dephosphorylation inferred from sequence or structural similarity with human PTEN (Goberdhan et al., 1999) non-traceable author statement (Morrison et al., 2000) regulation of cell size non-traceable author statement (Claeys et al., 2002) regulation of multicellular organism growth non-traceable author statement (Claeys et al., 2002) regulation of organ growth non-traceable author statement (Claeys et al., 2002) regulation of protein stability inferred from electronic annotation with InterPro:IPR017361 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Pten allele Gene References Pten1 Pi3K92E (Goberdhan et al., 1999) Pten2L100 Pi3K21B (Oldham et al., 2002) Pten117 foxo (Junger et al., 2003) lilli (Wittwer et al., 2001) Pi3K21B (Oldham et al., 2002) Tor (Oldham et al., 2000) Ptenc494 Pdk1 (Rintelen et al., 2001) Ptendj189 Akt1 (Gao et al., 2000) eIF-4a (Gao et al., 2000) Pdk1 (Rintelen et al., 2001) Pi3K92E (Gao et al., 2000) PtenScer\UAS.cGa Pi3K92E (Goberdhan et al., 1999) PtenScer\UAS.cGb EcR (Rusten et al., 2004) Pi3K92E (Gao et al., 2000) Tsc1 (Tapon et al., 2001) PtenScer\UAS.cHa chico (Huang et al., 1999) InR (Huang et al., 1999) Pi3K92E (Huang et al., 1999) Ptenunspecified Akt1 (Stocker et al., 2002) unspecified Akt1 (Kiger et al., 2003) CG34384 (Kiger et al., 2003) DJ-1α (Kim et al., 2005) gig (Tapon et al., 2001) LIMK1 (Kiger et al., 2003) MAPk-Ak2 (Kiger et al., 2003) Pi3K92E (Kiger et al., 2003) rictor (Hietakangas and Cohen, 2007) slpr (Kiger et al., 2003) wee (Kiger et al., 2003)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 68762 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0026379 DroID - A comprehensive database of gene and protein interactions. • FBgn0026379 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43991
Orthologs
Genome-wide drosophilid orthologs	Dana\GF14124 Dere\GG23962 Dgri\GH13854 Dmoj\GI18266 Dper\GL19174 Dpse\GA19047 Dsec\GM11890 Dsim\GD22287 Dvir\GJ17528 Dwil\GK15265 Dyak\GE26252
Curated drosophilid orthologs	Dpse\GA19047
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AGAP009628-PA Anopheles gambiae (mosquito) XP_395326.3 Apis mellifera (honey bee) At3g19420.1 Arabidopsis thaliana (wall cress) At3g50110.1 Arabidopsis thaliana (wall cress) 88827 Branchiostoma floridae (lancelet) BGIBMGA009071-PA Bombyx mori (silk worm) ENSBTAP00000035646 Bos taurus (bovine) CAL0000491 Candida albicans (a form of yeast) CBP17866 Caenorhabditis briggsae (nematode) ENSCAFP00000023027 Canis familiaris (dog) CAGL0L04180g Candida glabrata (haploid yeast) Chro.30223 Cryptosporidium hominis (obligate parasite) ENSCINP00000004840 Ciona intestinalis (sea squirt) cgd3_1890 Cryptosporidium parvum (protozoan parasite) ENSCPOP00000018437 Cavia porcellus (guinea pig) RP28668 Caenorhabditis remanei (nematode) ENSCSAVP00000017307 Ciona savignyi (sedentary tunicate) 90711 Capitella spl (polychaete worm) DDB0229881 Dictyostelium discoideum (amoeba) 49762 Daphnia pulex (daphnia) ENSDARP00000073594 Danio rerio (zebra fish) ENSECAP00000006650 Equus caballus (horse) XP_655519 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000012236 Gymnopilus aculeatus (mushroom) ENSGALP00000005747 Gallus gallus (chicken) GL50803_16728 Giardia lamblia (flagellated protozoan) 120014 Hypsipyla robusta (cedar shoot borer) ENSP00000361021 Homo sapiens (human) ISCW021211-PA Ixodes scapularis (deer tick) 195725 Lottia gigantea (owl limpet) 38555 Monocosta brevicollis (choanoflagellate) ENSMODP00000020601 Monodelphis domestica (gray opossum) ENSMMUP00000011055 Macaca mulatta (rhesus monkey) ENSMUSP00000013807 Mus musculus (house mouse) 131389 Nematostella vectensis (starlet anemone) XP_001601470.1 Nasonia vitripennis (wasp) ENSOANP00000013040 Ornithorynchus anatinus (platypus) ENSORLP00000007828 Oryzias latipes (japanese killifish) LOC_Os12g21890.1 Oryza sativa (asian rice) PHUM003797-PA Pediculus humanus (human body louse) ENSPPYP00000002838 Pongo pygmaeus (orangutan) 84941 Phytophthora ramorum (sudden oak death pathogen) 144659 Phytophthora sojae (root rot pathogen) 259295 Populus trichocarpa (black cottonwood) ENSPTRP00000004746 Pan troglodytes (chimpanzee) ENSRNOP00000028143 Rattus norvegicus (norway rat) 142278 Sorghum bicolor (sorghum) XP_795616.2 Strongylocentrotus purpuratus (purple sea urchin) 28654 Trichoplax adhaerens (metazoa) XP_974994.1 Tribolium castaneum (red flour beetle) Tc00.1047053510879.160 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000008724 Tetraodon nigroviridis (green spotted pufferfish) ENSTNIP00000016308 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000024744 Takifugu rubripes (pufferfish Takifugu) 3728.m00047 Tetrahymena thermophila (ciliate protozoa) 81840.m00178 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000020363 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB18578 NV15889 LH15756 ISCW021211 FBgn0243283 FBgn0217270 FBgn0204698 FBgn0193695 FBgn0166831 JGI_V11_49762 FBgn0079045 FBgn0156773 FBgn0141005 FBgn0121330 FBgn0116101 FBgn0091151 CPIJ008808 BGIBMGA009070 BGIBMGA009071 ACYPI004294 GB14441 AGAP009628 AAEL017224 PHUM471760 GLEAN_05314
Stocks & Reagents
Stocks Listed in FlyBase ( 10 )
Bloomington	8550 w1118; P{UAS-Pten.dsRNA.Exel}3 25841 y1 v1; P{TRiP.JF01859}attP2 33643 y1 v1; P{TRiP.HMS00044}attP2 8548 P{UAS-Pten.dsRNA.Exel}1, y1 w1118 8549 y1 w1118; P{UAS-Pten.dsRNA.Exel}2 25967 y1 v1; P{TRiP.JF01987}attP2/TM3, Sb1 16275 y1 w1118; PBac{3HPy+}PtenC076/CyO
Harvard	- PBac{WH}Ptenf04844
VDRC	v101475 P{KK109278}VIE-260B v35731 w1118; P{GD13500}v35731
Genomic Clones ( 2 )
	BACR07H08 BACR30M19 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 40 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	IP16020
Other clones	DPiM_IP16020
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LP04865 RE05970 RE07023 RE20136 RE41458 RE48862 RE50762 RE64115 RE66028
Other clones	14870 30423 31540 46802 54792 56960 103607 104644 148894 161485 165423 180184 bs64d06 Dmel_neb_013338_0438_1077 EK034305 EK117232 EK138431 EK141358 EK170529 EK171137 EK179719 EK251309 EK255133 EK265318 EK287932 IP16120 IP16220 IP16320 UUGC0282
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0026379 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43991
Antibody Information
	polyclonal (Ramachandran et al., 2009)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Pten CG5671 (Bayraktaroglu, 2000.4.13)
Additional comments
Other Comments
	dsRNA has been made from templates generated with primers directed against this gene. (Frias et al., 2006) dsRNA made from templates generated with primers directed against this gene results in an increase in mean cell diameter. (Guertin et al., 2006) dsRNA made from templates generated with primers directed against this gene increase the levels of phosphorylation of boh Akt1 and S6k in S2 cells. (Yang et al., 2006) dsRNA made from templates generated with primers directed against this gene used to treat S2 cells. (Yang et al., 2006) One of 42 Drosophila genes identified as being most likely to reveal molecular and cellular mechanisms of nervous system development or plasticity relevant to human Mental Retardation disorders. (Inlow and Restifo, 2004) PI3K activity is regulated through EcR signalling in a cell-autonomous manner to allow programmed autophagy in the fat body. (Rusten et al., 2004) RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167 cells: change from round to spindle-shaped, with the formation of F-actin puncta and microtubule extensions. Alterations of cell shape are also evident in S2R+ cells - they become round and detached. The Kc167 cell-shape change is suppressed by simultaneous treatment with dsRNA targetted against Akt1, CG31187, LIMK1, MAPk-Ak2, Pi3K92E, slpr or wee. (Kiger et al., 2003) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) Pten plays an essential role in the control of, cell size, cell number, and organ size. (Gao et al., 2000) Pten acts antagonistically to Pi3K92E and chico. In direction of increasing cytology: chico- bsk- Ror+ Pten- (Goberdhan et al., 1999) Pten has a complex role in regulating tissue and body size. Pten regulates the subcellular organization of the actin cytoskeleton in multiple cell types. (Goberdhan et al., 1999) Both inactivation and overexpression of Pten affect cell size, and overexpression of Pten inhibits cell cycle progression at early mitosis and promotes cell death during eye development. Phenotypes caused by overexpression of Hsap\PTEN and Pten are indistinguishable. (Huang et al., 1999) The phosphatase activity of Pten is necessary for it to exert its functions during development. In direction of increasing cytology: Rsf1+ Pten+ CG5676+ Ror- bsk+ chico+ (Huang et al., 1999) Pten acts in the insulin signalling pathway. All signals from the InR protein can be antagonized by Pten. (Huang et al., 1999) Pten regulates cell size and cell proliferation via the actin cytoskeleton. (Wilson et al., 1999)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_058074 NM_058075 NM_058076 NM_134320 NM_134321 NM_134322 NM_001169462 RefSeq (Proteins) • NP_477422 NP_477423 NP_477424 NP_599147 NP_599148 NP_599149 NP_001162933 DDBJ / EMBL / GenBank • AAD45362 AAD45363 AAD45364 AAF08382 AAF23235 AAF23236 AAF23237 AAF23238 AAF52887 AAF52888 AAF52889 AAN10730 AAN10731 AAN10732 AC005454 AC009849 ACZ94222 AF144232 AF161257 AF161258 AF161259 AF201904 AF201905 AF201906 AF201907 AI260874 Entrez Gene - A searchable database of RefSeq genes. • 43991 UniProtKB/TrEMBL • Q7KJN5 Q7KJN6 Q7KMQ6 Q9U470 Q9V3L4 Q9Y0B5 Q9Y0B6
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Dual specificity phosphatase, catalytic domain (IPR000340) C2 calcium/lipid-binding domain, CaLB (IPR008973) Phosphatase tensin type (IPR014019) Tensin phosphatase, C2 domain (IPR014020) Protein-tyrosine phosphatase, active site (IPR016130) Bifunctional phosphatidylinositol trisphosphate phosphatase/dual-specificity phosphatase PTEN (IPR017361)
Linkouts
	BioGRID - A database of protein and genetic interactions • 68762 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0026379 DroID - A comprehensive database of gene and protein interactions. • FBgn0026379 DRSC - Results from RNAi screens. • FBgn0026379 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0026379 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5671-RC;CG5671-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0026379 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43991 InParanoid A subset of ortholog calls from InParanoid. • AGAP009628-PA Anopheles gambiae (mosquito) XP_395326.3 Apis mellifera (honey bee) At3g19420.1 Arabidopsis thaliana (wall cress) At3g50110.1 Arabidopsis thaliana (wall cress) 88827 Branchiostoma floridae (lancelet) BGIBMGA009071-PA Bombyx mori (silk worm) ENSBTAP00000035646 Bos taurus (bovine) CAL0000491 Candida albicans (a form of yeast) CBP17866 Caenorhabditis briggsae (nematode) ENSCAFP00000023027 Canis familiaris (dog) CAGL0L04180g Candida glabrata (haploid yeast) Chro.30223 Cryptosporidium hominis (obligate parasite) ENSCINP00000004840 Ciona intestinalis (sea squirt) cgd3_1890 Cryptosporidium parvum (protozoan parasite) ENSCPOP00000018437 Cavia porcellus (guinea pig) RP28668 Caenorhabditis remanei (nematode) ENSCSAVP00000017307 Ciona savignyi (sedentary tunicate) 90711 Capitella spl (polychaete worm) DDB0229881 Dictyostelium discoideum (amoeba) 49762 Daphnia pulex (daphnia) ENSDARP00000073594 Danio rerio (zebra fish) ENSECAP00000006650 Equus caballus (horse) XP_655519 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000012236 Gymnopilus aculeatus (mushroom) ENSGALP00000005747 Gallus gallus (chicken) GL50803_16728 Giardia lamblia (flagellated protozoan) 120014 Hypsipyla robusta (cedar shoot borer) ENSP00000361021 Homo sapiens (human) ISCW021211-PA Ixodes scapularis (deer tick) 195725 Lottia gigantea (owl limpet) 38555 Monocosta brevicollis (choanoflagellate) ENSMODP00000020601 Monodelphis domestica (gray opossum) ENSMMUP00000011055 Macaca mulatta (rhesus monkey) ENSMUSP00000013807 Mus musculus (house mouse) 131389 Nematostella vectensis (starlet anemone) XP_001601470.1 Nasonia vitripennis (wasp) ENSOANP00000013040 Ornithorynchus anatinus (platypus) ENSORLP00000007828 Oryzias latipes (japanese killifish) LOC_Os12g21890.1 Oryza sativa (asian rice) PHUM003797-PA Pediculus humanus (human body louse) ENSPPYP00000002838 Pongo pygmaeus (orangutan) 84941 Phytophthora ramorum (sudden oak death pathogen) 144659 Phytophthora sojae (root rot pathogen) 259295 Populus trichocarpa (black cottonwood) ENSPTRP00000004746 Pan troglodytes (chimpanzee) ENSRNOP00000028143 Rattus norvegicus (norway rat) 142278 Sorghum bicolor (sorghum) XP_795616.2 Strongylocentrotus purpuratus (purple sea urchin) 28654 Trichoplax adhaerens (metazoa) XP_974994.1 Tribolium castaneum (red flour beetle) Tc00.1047053510879.160 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000008724 Tetraodon nigroviridis (green spotted pufferfish) ENSTNIP00000016308 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000024744 Takifugu rubripes (pufferfish Takifugu) 3728.m00047 Tetrahymena thermophila (ciliate protozoa) 81840.m00178 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000020363 Xenopus tropicalis (frog) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /cytoskel/pten1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43991 modMine - Data generated by the modENCODE project. • FBgn0026379 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB18578 NV15889 LH15756 ISCW021211 FBgn0243283 FBgn0217270 FBgn0204698 FBgn0193695 FBgn0166831 JGI_V11_49762 FBgn0079045 FBgn0156773 FBgn0141005 FBgn0121330 FBgn0116101 FBgn0091151 CPIJ008808 BGIBMGA009070 BGIBMGA009071 ACYPI004294 GB14441 AGAP009628 AAEL017224 PHUM471760 GLEAN_05314
Synonyms & Secondary IDs ( 15 )
Reported As
Symbol Synonym	CG5671 (Goldstein and Gunawardena, 2000, Morrison et al., 2000, Perkins et al., 1.15.2009, Keleman et al., 2009.8.5, Ni et al., 2010.12.1) dPTEN (Wu et al., 2005, Sarbassov et al., 2005, Wessells et al., 2004, Burgering and Kops, 2002, Findlay et al., 2005, Maehama et al., 2004, Junger et al., 2003, Szuplewski et al., 2003, Raisin et al., 2003, Jin et al., 2001, Downward and Leevers, 2001, Oldham and Hafen, 2003, Marygold and Leevers, 2002, Radimerski et al., 2002, Prober and Edgar, 2002, Stocker et al., 2002, Oldham et al., 2002, Kozma and Thomas, 2002, Britton et al., 2002, Rintelen et al., 2001, Gingras et al., 2001, Potter et al., 2001, Zhang et al., 2000, Stocker and Hafen, 2000, Gao et al., 2000, Huang et al., 1999, DiAngelo and Birnbaum, 2007, Yang et al., 2006, Gao et al., 2005, Yang et al., 2006, DiAngelo and Birnbaum, 2006, Kim et al., 2005, Cavaliere et al., 2005, Miron et al., 2003, Dekanty et al., 2005, Kim et al., 2008, Lizcano et al., 2003, Read et al., 2009, Montagne et al., 2010, Honegger et al., 2008, Porstmann et al., 2008, Kim et al., 2004) DPTEN (Partridge, 2005, Claeys et al., 2002, Towers and Sattelle, 2002, Goberdhan and Wilson, 2002, Goberdhan and Wilson, 2002, Coelho and Leevers, 2000, Clemens et al., 2000, Potter et al., 2000, Goberdhan et al., 1999, Smith et al., 1999, Wilson et al., 1999, Scanga et al., 2000) dPten (Wittwer et al., 2005) dpten (Ma et al., 2008) pten (McNeill et al., 2008, Bateman and McNeill, 2004, Lee and Orr-Weaver, 2003, Menut et al., 2007, Ramachandran et al., 2009, Wang et al., 2009) PTEN (Mirth et al., 2005, Shingleton, 2005, Cygnar, 2005, Scott et al., 2004, Scott et al., 2004, Pan et al., 2004, McNeill and Bateman, 2005, Bilder, 2004, von Stein et al., 2003, Clague et al., 2004, von Stein et al., 2004, Gao et al., 2002, Oldham et al., 2001, Neufeld, 2001.1.11, Wilson et al., 2000, Weinkove and Leevers, 2000, Potter et al., 2000, Smith, 1999.6.23, Smith, 1999.6.23, Smith, 1999.6.23, Edgar, 2006, Vereshchagina and Wilson, 2006, Tyler et al., 2007, Palmer and Pichaud, 2007, Wilson et al., 2007, Fehon, 2006, Mikeladze-Dvali et al., 2005, Edgar, 2006, Betschinger et al., 2006, Guertin et al., 2006, Bergman et al., 2007, Frias et al., 2006, Cortina-Andrada et al., 2007, Basu and Krek, 2007, Shiojima, 2006, Gutierrez et al., 2007, Hoshizaki and Gibbs, 2007, Libert, 2007, Frias et al., 2006, Howlett et al., 2008, Ikeya et al., 2009, Seisenbacher et al., 2008, Hietakangas and Cohen, 2007, Hardie, 2003, Mesquita et al., 2010, Scanga et al., 2000, Bakal et al., 2008, Jovceva et al., 2007, Vereshchagina et al., 2008, Rafel and Milán, 2008, Lee et al., 2008, Lee et al., 2010, Hall et al., 2007, Read et al., 2009, Shelly et al., 2009, Ninov et al., 2009, Juhasz et al., 2007, Nuzhdin et al., 2009, Mattila et al., 2008, Pinal et al., 2006, Werz et al., 2009, Zheng and Sehgal, 2010, Delanoue et al., 2010, Tsuda et al., 2010, Honegger et al., 2008, Resnik-Docampo and de Celis, 2011, Montagne et al., 2010) Pten (Wiggin et al., 2005, Bruckner et al., 2004, Knox et al., 2007, Friedman and Perrimon, 2006, Nedelsky et al., 2010, Chen et al., 2007, Yin et al., 2008, Zhou et al., 2008, Hou et al., 2008, Demontis and Perrimon, 2009, Rhiner et al., 2009, Alvarez-Ponce et al., 2009, Lee et al., 2010, Mirth et al., 2009, Ford et al., 2007, Qian and Bodmer, 2009, Parrish et al., 2009, Doumanis et al., 2009, Mummery-Widmer et al., 2009, Sims et al., 2009, Kim et al., 2010, Sousa-Nunes et al., 2011, Haberman et al., 2010, Djiane et al., 2011, Demontis and Perrimon, 2010, Eddison et al., 2011) PTEN3 (Goldstein and Gunawardena, 2000)
Name Synonym	Drosophila phosphatase and tensin homologue deleted on chromosome 10 (Lizcano et al., 2003) phosphatase and tensin homolog (Lee et al., 2010) Phosphatase and tensin homologue (Lee et al., 2008) phosphatidylinositol (3,4,5)-trisphosphate phosphatase (Jovceva et al., 2007) PI 3-phosphatase (Hardie, 2003) PtdIns(3,4,5)P3 phosphatase (Jovceva et al., 2007) Pten (Zhou et al., 2008, Mummery-Widmer et al., 2009) PTEN (Hall et al., 2007)
Secondary FlyBase IDs
	FBgn0032201
References ( 227 )
Generate a list of	All references relating to this gene ( 227 )
List References by type	Research paper  ( 127 ) Supplementary material  ( 11 ) Review  ( 38 ) Personal communication to FlyBase  ( 13 ) Abstract  ( 24 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 5 ) Conference report  ( 2 ) Letter  ( 1 ) Computer file  ( 1 ) Curated genome annotation  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 19 )
	Cheng et al., 2011, Cell 146(3): 435--447 Anaplastic Lymphoma Kinase Spares Organ Growth during Nutrient Restriction in Drosophila. [FBrf0214599] Djiane et al., 2011, J. Cell Biol. 192(1): 189--200 Su(dx) E3 ubiquitin ligase-dependent and -independent functions of Polychaetoid, the Drosophila ZO-1 homologue. [FBrf0212737] Eddison et al., 2011, Neuron 70(5): 979--990 arouser Reveals a Role for Synapse Number in the Regulation of Ethanol Sensitivity. [FBrf0213908] Horn et al., 2011, Nat. Methods 8(4): 341--346 Mapping of signaling networks through synthetic genetic interaction analysis by RNAi. [FBrf0213352] Nakajima et al., 2011, Mol. Cell. Biol. 31(12): 2499--2512 Nonautonomous Apoptosis Is Triggered by Local Cell Cycle Progression during Epithelial Replacement in Drosophila. [FBrf0213728] Poon et al., 2011, Dev. Cell 21(5): 896--906 The Sterile 20-like Kinase Tao-1 Controls Tissue Growth by Regulating the Salvador-Warts-Hippo Pathway. [FBrf0216620] Resnik-Docampo and de Celis, 2011, PLoS ONE 6(1): e14528 MAP4K3 Is a Component of the TORC1 Signalling Complex that Modulates Cell Growth and Viability in Drosophila melanogaster. [FBrf0212911] Roubinet et al., 2011, J. Cell Biol. 195(1): 99--112 Molecular networks linked by Moesin drive remodeling of the cell cortex during mitosis. [FBrf0216647] Sousa-Nunes et al., 2011, Nature 471(7339): 508--512 Fat cells reactivate quiescent neuroblasts via TOR and glial insulin relays in Drosophila. [FBrf0214426] Delanoue et al., 2010, Dev. Cell 18(6): 1012--1021 The steroid hormone ecdysone controls systemic growth by repressing dMyc function in Drosophila fat cells. [FBrf0211284] Demontis and Perrimon, 2010, Cell 143(5): 813--825 FOXO/4E-BP Signaling in Drosophila Muscles Regulates Organism-wide Proteostasis during Aging. [FBrf0212347] Haberman et al., 2010, Development 137(13): 2157--2166 Drosophila acinus encodes a novel regulator of endocytic and autophagic trafficking. [FBrf0211007] Kim et al., 2010, BMC Cell Biol. 11: 9 A genetic screen for modifiers of Drosophila caspase Dcp-1 reveals caspase involvement in autophagy and novel caspase-related genes. [FBrf0209948] Lee et al., 2010, Science 327(5970): 1223--1228 Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies. [FBrf0210161] Mesquita et al., 2010, PLoS Biol. 8(12): e1000566 A dp53-Dependent Mechanism Involved in Coordinating Tissue Growth in Drosophila. [FBrf0212630] Montagne et al., 2010, PLoS Genet. 6: e1000937 The nuclear receptor DHR3 modulates dS6 kinase-dependent growth in Drosophila. [FBrf0210767] Nedelsky et al., 2010, Neuron 67(6): 936--952 Native functions of the androgen receptor are essential to pathogenesis in a Drosophila model of spinobulbar muscular atrophy. [FBrf0211903] Tsuda et al., 2010, FEBS Lett. 584(22): 4689--4694 POSH promotes cell survival in Drosophila and in human RASF cells. [FBrf0212255] Zheng and Sehgal, 2010, Curr. Biol. 20(13): 1203--1208 AKT and TOR Signaling Set the Pace of the Circadian Pacemaker. [FBrf0211221] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...