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Gene Dmel\Or22a

General Information
Symbol	Dmel\Or22a	Species	D. melanogaster
Name	Odorant receptor 22a	Annotation symbol	CG12193
Feature type	protein_coding_gene	FlyBase ID	FBgn0026398
Created / Updated	2003-12-01/2003-12-01
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	22A2-22A2	Sequence location	2L:1,520,613..1,522,151 [+]
Map ( GBrowse )	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Odorant receptor 22a is referred to in FlyBase by the symbol Or22a (CG12193, FBgn0026398). It has the cytological map location 22A2. Its sequence location is 2L:1520613..1522151. Its molecular function is described as: olfactory receptor activity; odorant binding. It is involved in the biological process sensory perception of smell. 8 alleles are reported. The phenotype of these alleles is annotated with olfactory neuron. It has one annotated transcript and one annotated polypeptide.
External Summaries
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 22A2-22A2   Limits computationally determined from genome sequence between P{PZ}l(2)1068510685&P{lacW}Tango14k00619 and P{lacW}RFeSPk11704
Experimentally Determined Cytological Location
Cytogenetic map Notes References 22A2-22A3   (Vosshall, 1999.2.9)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology) References In direction of increasing cytology: Or22a+ Or22b+ (Clyne et al., 1999) Gene Order (overall orientation not stated) References
Gene Model & Products
Please see the GBrowse view of Dmel\Or22a for information on other features
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Or22a-RA FBtr0077873  NM_078729   1294   397
Additional Transcript Data & Comments
Reported size (kB)	1.305 (longest cDNA) (Vosshall et al., 1999)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kD) Length (aa) Theoretical pI RefSeq ID GenBank protein Or22a-PA   FBpp0077541   46.8   397   7.62     NP_523453   AAF51364
Additional Polypeptide Data & Comments
Reported size (kD)	393 (aa) (Vosshall et al., 1999) 404 (aa) (Gao and Chess, 1999)
Comments
External Data
Linkouts	PANTHER - Protein classification by function, families, and pathways • FBgn0026398
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Olfactory receptor, Drosophila (IPR004117)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AC004121   AE003586 AAF51364   AF127923 AAD26358   BD268280   CO278430   CO321005   CO328891   EC051855   EC054272   EC056496   EC198671
UniProtKB/Swiss-Prot	P81909
UniProtKB/TrEMBL
Maps to	DS05342 (Clyne et al., 1999, Vosshall et al., 1999)
Does NOT map to
Identified with
Mapped Features & Mutations
Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here Type Symbol & Location Additional Notes References rescue fragment Or22a[+tDa] 2L:1,512,417..1,524,408 comment=Position of restriction fragment on reference sequence inferred by FlyBase curator. evidence=experimental (Dobritsa et al., 2003)
External Data
Linkouts	DEDB - Drosophila exon database: splicing graphs • 5701
Crossreferences
Expression Data
FlyBase-Curated Data
Transcript and Protein data	Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
Summary of Transcript Expression
Stage Tissue/Position Reference  adult stage  sensory neuron <of> antennal segment 3 (Gao and Chess, 1999)
Marker for
Subcellular Localization
CV Term
Summary of Polypeptide Expression
Stage Tissue/Position Reference
Marker for
Subcellular Localization
CV Term
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0026398 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • FBgn0026398 GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies • FBgn0026398
Alleles & Phenotypes
Summary of Allele Phenotypes
Other Phenotypes Allele neurophysiology defective, with Scer\GAL4Or67d.PF Or22aScer\UAS.cLb Phenotype manifest in Allele olfactory neuron, with Scer\GAL4Or67d.PF Or22aScer\UAS.cLb
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of Or22a Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Or22a Class Mutagen Stocks Known lesion Or22a+tDa in vitro construct | genomic fragment 0 Yes Or22aGD17729 in vitro construct | RNAi in vitro construct | regulatory fusion 1 Yes Or22aGD805 in vitro construct | RNAi in vitro construct | regulatory fusion 0 Yes Or22aScer\UAS.T:Hsap\MYC in vitro construct | regulatory fusion in vitro construct | coding region fusion 0 Yes Or22aScer\UAS.cLb in vitro construct | regulatory fusion 0 Yes Or22aT:Avic\GFP in vitro construct | coding region fusion in vitro construct | minigene 0 Yes Or22acDa in vitro construct | other 0 Yes Or22atDb in vitro construct | other 0 Yes
Aneuploid Aberrations
Useful deficiency	Df(2L)frtz17
Useful duplication	Dp(2;2)M+Su24+-1
Disrupted in	Df(2L)Exel8004 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD17729} NA P{GD805} NA P{UAS-Or22a.myc} NA characterization construct P{Or22a-GAL4.7.717} NA P{Or22a-GAL4.8010} NA P{Or22a-GAL4.8197} NA P{Or22a-Mmus\Cd8a.GFP} NA P{Or22a-dsRed.8197} NA P{Or22a+Or22b+} NA P{Or22a+Or22b-} NA P{Or22a-Or22b+} NA P{Or22a-Or22b-} NA
Insertions
	Type of insertions Name Expression data
Related Comments
	Please look at the allele reports for the complete phenotype data
Gene Ontology: Function, Process & Cellular Component ( 6 )
Molecular Function
CV term Evidence References
odorant binding inferred from electronic annotation with InterPro:IPR004117 (FlyBase Curators et al., 2004-)
olfactory receptor activity non-traceable author statement (Swiss-Prot Project Members, 1999.8.1) inferred from direct assay (Hallem and Carlson, 2006)
Biological Process
CV term Evidence References
sensory perception of smell inferred from mutant phenotype (Dobritsa et al., 2003) non-traceable author statement (Swiss-Prot Project Members, 1999.8.1)
Cellular Component
CV term Evidence References
dendrite inferred from direct assay (Dobritsa et al., 2003)
integral to membrane non-traceable author statement (Swiss-Prot Project Members, 1999.8.1)
membrane inferred from electronic annotation with InterPro:IPR004117 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	protein_coding_gene   nuclear_gene
Interactions & Pathways
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Or22a allele Gene References
External Data
Linkouts	BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions • 59579
Orthologs
Genome-wide drosophilid orthologs	Dana\GF15846 Dsim\GD23102
Curated drosophilid orthologs	Dpse\Or22a1 (Richards et al., 2005.6.27) Dsim\Or22a (Dobritsa et al., 2003)
Linkouts
Functional Complementation between Species
Inter-Species Misexpression Data
Produces phenotype in
Produces NO phenotype in
Stocks & Reagents
Stocks Listed in FlyBase ( 1 )
VDRC	v49835 w1118; P{GD17729}v49835
Genomic Clones ( 1 )
	BACR28O09
cDNA Clones ( 6 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	EC054272 EC056496 EK290124 EK130046 EC051855 EK291616
RNAi & Array Information
Affy Oligo
Linkouts	DRSC - RNAi screening (Harvard): high-throughput cell culture data and design • FBgn0026398 GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data • FBgn0026398
Antibody Information
Other Information
Discoverer
Etymology
Identification
Position Effect Variegation Data
Relationship to Other Genes
Source for database identity of	Source for identity of: Or22a Or22A.1 (Warr and Vosshall, 2000.5.19)
Source for database merge of
Additional comments
Comments About Role
Comments About Molecular Function
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078729 RefSeq (Proteins) • NP_523453 DDBJ / EMBL / GenBank • AC004121 AE003586 AAF51364 AF127923 AAD26358 BD268280 UniProtKB/Swiss-Prot • P81909
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Olfactory receptor, Drosophila (IPR004117)
Linkouts
	BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions • 59579 DEDB - Drosophila exon database: splicing graphs • 5701 DRSC - RNAi screening (Harvard): high-throughput cell culture data and design • FBgn0026398 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0026398 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • FBgn0026398 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0026398 GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies • FBgn0026398 GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data • FBgn0026398 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /hjmuller/or22s-1.htm PANTHER - Protein classification by function, families, and pathways • FBgn0026398
Synonyms & Secondary IDs ( 18 )
Reported As
Symbol Synonym	22a (Vogt et al., 2002) 22A.1 (Warr and Vosshall, 2000.5.19) AN11 (Warr and Vosshall, 2000.5.19, Gao and Chess, 1999, ) CG12193 (Warr and Vosshall, 2000.5.19, ) Dmel22a (Dekker et al., 2006) Dmel Or22a (Dekker et al., 2006) DOR22a (Dobritsa et al., 2001, Neuhaus et al., 2005) DOR22A.1 (Clyne et al., 1999) DOR53 (Warr and Vosshall, 2000.5.19) Dor53 (Vosshall, 1999.2.9, ) dor53 (Vosshall et al., 1999) Or22a (Hallem and Carlson, 2006, de Bruyne and Warr, 2006, Komiyama et al., 2004, Goldman et al., 2005, Dobritsa et al., 2003, Bargmann, 2006, van der Goes van Naters and Carlson, 2006, Benton et al., 2007, Benton et al., 2007, Dekker et al., 2006, Dekker et al., 2006) OR22a (Benton et al., 2006, Gross, 2006) Or22A.1   Or53
Name Synonym	Odorant receptor 22a   Odorant receptor 53   Olfactory receptor 22A.1 (Clyne et al., 1999)
Secondary FlyBase IDs
References ( 50 )
Generate a list of	All references relating to this gene ( 50 )
List References by type	Research paper  ( 26 ) Supplementary material  ( 4 ) Review  ( 6 ) Personal communication to FlyBase  ( 4 ) Abstract  ( 2 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 2 ) Patent  ( 1 ) Protein sequence record  ( 1 ) Curated genome annotation  ( 1 ) Automatic genome annotation  ( 1 ) Letter  ( 1 )
Recent research papers ( 4 )
	Benton et al., 2007, Nature 450(7167): 289--293 An essential role for a CD36-related receptor in pheromone detection in Drosophila. [FBrf0202608] Benton et al., 2006, PLoS Biol. 4(2): e20 Atypical membrane topology and heteromeric function of Drosophila odorant receptors in vivo. [FBrf0192657] Dekker et al., 2006, Curr. Biol. 16(1): 101--109 Olfactory shifts parallel superspecialism for toxic fruit in Drosophila melanogaster sibling, D. sechellia. [FBrf0190007] Hallem and Carlson, 2006, Cell 125(1): 143--160 Coding of odors by a receptor repertoire. [FBrf0189911] Show all research papers ...
Recent reviews ( 4 )
	Bargmann, 2006, Nature 444(7117): 295--301 Comparative chemosensation from receptors to ecology. [FBrf0194573] de Bruyne and Warr, 2006, BioEssays 28(1): 23--34 Molecular and cellular organization of insect chemosensory neurons. [FBrf0189797] Gross, 2006, PLoS Biol. 4(2): e34 A novel design principle for the insect odorant receptor. [FBrf0200116] van der Goes van Naters and Carlson, 2006, Nature 444(7117): 302--307 Insects as chemosensors of humans and crops. [FBrf0200019] Show all reviews ...