• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • RNA-Seq Search
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • GBrowse 2 Beta
    • CytoSearch
    • Feature Mapper
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Current release
  • Archived releases
  • Map Conversion
  • FTP site:
  • Releases (FTP)
  • Genomes (FTP)
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Vectors & Constructs
  • Other links:
  • BDGP
  • DGRC
  • DIS by issue
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\Nipped-B

General Information
Symbol	Dmel\Nipped-B	Species	D. melanogaster
Name	Nipped-B	Annotation symbol	CG17704
Feature type	protein_coding_gene	FlyBase ID	FBgn0026401
Gene Model Status	Current	Stock availability	5 publicly available
Also Known As	l(2)02047
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	41B3-41C1	Sequence location	2R:579,177..616,522 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Nipped-B is referred to in FlyBase by the symbol Dmel\Nipped-B (CG17704, FBgn0026401). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding. There is experimental evidence that it is involved in the biological process: transcriptional activation by promoter-enhancer looping; synaptonemal complex organization; mitotic sister chromatid cohesion; positive regulation of gene expression; regulation of transcription, DNA-dependent. 38 alleles are reported. The phenotypes of these alleles are annotated with: adult abdomen; male genitalia; synaptonemal complex. It has 6 annotated transcripts and 6 annotated polypeptides. Protein features are: Armadillo-like helical; Armadillo-type fold; HEAT repeat associated with sister chromatid cohesion protein; Sister chromatid cohesion C-terminal domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-18 hour embryonic stages, during early pupal stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: No FlyAtlas data available because no Affy2 ProbeSet aligns to an exon of Nipped-B. Comments on Affy2 ProbeSet: No relevant information because no Affy2 ProbeSet aligns to an exon of Nipped-B. Gene sequence location is 2R:579177..616522.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 41B3-41C1
Experimentally Determined Cytological Location
Cytogenetic map Notes References 41C1-41C6   h46   (Drosophila Heterochromatin Genome Project, 2004) h46-h46   (determined by in situ hybridisation)   (Corradini et al., 2003) 41A-41A     (Rollins, 1998.12.15) 41C1-41C6   (determined by in situ hybridisation)   (Spradling et al., 1999) 41A-41A     (Dorsett, 1999.3.3) 41C1-41C6   48D5--6   (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location	2- (Rollins et al., 1998, Rollins et al., 1997)
Left of (cM)	stw (Dorsett, 1999.3.3)
Right of (cM)	RpL38 (Dorsett, 1999.3.3)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Nipped-B for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.47 Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Nipped-B-RE FBtr0111119  NM_001042987   6711   2077 Nipped-B-RF FBtr0111118  NM_001042986   6683   2077 Nipped-B-RG FBtr0301454  NM_001169581   6604   2053 Nipped-B-RH FBtr0301455  NM_001169582   6639   2053 Nipped-B-RI FBtr0301456  NM_001169583   6611   2053 Nipped-B-RJ FBtr0334994  NM_001273774   6273   1957
Additional Transcript Data & Comments
Reported size (kB)	7.0 (northern blot) (Rollins et al., 1999)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Nipped-B-PE   FBpp0110411   236.7   2077   6.53     NP_001036452   EAA46004 Nipped-B-PF   FBpp0110410   236.7   2077   6.53     NP_001036451   EAA46003 Nipped-B-PG   FBpp0290669   233.9   2053   6.42     NP_001163052   ACZ94332 Nipped-B-PH   FBpp0290670   233.9   2053   6.42     NP_001163053   ACZ94333 Nipped-B-PI   FBpp0290671   233.9   2053   6.42     NP_001163054   ACZ94334 Nipped-B-PJ   FBpp0307004   223.3   1957   6.45     NP_001260703   AGB93238
Additional Polypeptide Data & Comments
Reported size (kDa)	2053 (aa) (Rollins et al., 1999)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Sister chromatid cohesion C-terminal domain (IPR024986) Armadillo-type fold (IPR016024) Armadillo-like helical (IPR011989) HEAT repeat associated with sister chromatid cohesion protein (IPR026003)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201759   AABU01002769 EAA46003   AABU01002769 EAA46004   AE013599 ACZ94332   AE013599 ACZ94333   AE013599 ACZ94334   AF114160 AAD26161   AE013599 AGB93238   AW941568   BE976487   BI169067   BI484337   BI486123   BI486234   BI634967   BP540855   BP558734   BP558735   BT029134   BT029135   BT031155   CO153918   CO156418   CO156673   CO177857   CO178762   CO186516   CO186562   CO186608   CO186747   CO187153   CO187407   CO188351   CO189316   CO190058   CO194861   CO196192   CO261951   CO263231   CO263464   CO264353   CO264806   CO266068   CO271212   CO272075   CO272558   CO273073   CO273762   CO274698   CO275072   CO276694   CO278111   CO279196   CO280145   CO283833   CO285782   CO288843   CO291598   CO292216   CO297422   CO297666   CO303515   CO308292   CO308309   CO308899   CO309784   CO310358   CO310866   CO312126   CO312632   CO312685   CO316733   CO321178   CO321236   CO322807   CO323810   CO324052   CO325325   CO329098   CO331786   CO332670   CO333038   CO335696   CO339025   CO342923   AE013599 EAA46003   AE013599 EAA46004   EC057374   EC058713   EC059947   EC060514   EC061498   EC061780   EC063025   EC066554   EC068811   EC076893   EC079098   EC081987   EC086181   EC086199   EC087908   EC194949   EC195104   EC195109   EC195483   EC197031   EC198180   EC200937   EC202151   EC203165   EC203830   EC209390   EC209828   EC210081   EC210121   EC213705   EC215036   EC216112   EC217007   EC217689   EC218728   EC220522   EC223585   EC224919   EC224995   EC226570   EC228812   EC229431   EC236600   EC236884   EC240788   EC243790   EC244277   EC244551   EC247975   EC248367   EC248423   EC251205   EC253779   EC258419   EC258493   EC264863   EC264885   EC265922   EL873116   EV575482   EV580433   EV584745   EV593316   EV596071   EV597708   G00522   GH747694   GH751800   GH754725   GH756534   GH757600   GH778556   GH784460   GH870671   GH904266
UniProtKB/Swiss-Prot	Q7PLI2
UniProtKB/TrEMBL	E1JGX3
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | faint & ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | faint & ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   organism | faint & ubiquitous   (Fisher et al., 2012) embryonic stage 13 -- 16   organism | faint & ubiquitous   (Fisher et al., 2012) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Rollins et al., 1999)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
colocalizes_with cohesin complex inferred from direct assay (Gause et al., 2010, Gause et al., 2008) nucleoplasm inferred from direct assay (Gause et al., 2010) nucleus inferred from direct assay (Rollins et al., 2004, Gause et al., 2008) polytene chromosome inferred from direct assay (Gause et al., 2008) protein complex inferred from direct assay (Gause et al., 2008) colocalizes_with synaptonemal complex inferred from direct assay (Gause et al., 2008) transcriptionally active chromatin inferred from direct assay (Misulovin et al., 2008)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    21 central nervous system, larvae L3    22 central nervous system, pupae P8    22 head, virgin 1-day female    10 head, virgin 4-day female    7 head, virgin 20-day female    9 head, mated 1-day female    7 head, mated 4-day female    9 head, mated 20-day female    8 head, mated 1-day male    10 head, mated 4-day male    15 head, mated 20-day male    12 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    9 digestive system, 4-day adult    9 digestive system, 20-day adult    6 fat body, larvae L3 wandering    3 fat body, white prepupae    9 fat body, pupae P8    7 carcass, larvae L3 wandering    12 carcass, 1-day adult    7 carcass, 4-day adult    9 carcass, 20-day adult    6 ovary, virgin 4-day female    68 ovary, mated 4-day female    33 testis, mated 4-day male    5 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    21 central nervous system, larvae L3    22 central nervous system, pupae P8    22 head, virgin 1-day female    10 head, virgin 4-day female    7 head, virgin 20-day female    9 head, mated 1-day female    7 head, mated 4-day female    9 head, mated 20-day female    8 head, mated 1-day male    10 head, mated 4-day male    15 head, mated 20-day male    12 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    9 digestive system, 4-day adult    9 digestive system, 20-day adult    6 fat body, larvae L3 wandering    3 fat body, white prepupae    9 fat body, pupae P8    7 carcass, larvae L3 wandering    12 carcass, 1-day adult    7 carcass, 4-day adult    9 carcass, 20-day adult    6 ovary, virgin 4-day female  (68) ovary, mated 4-day female  (33) testis, mated 4-day male    5 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    21 central nervous system, larvae L3    22 central nervous system, pupae P8    22 head, virgin 1-day female    10 head, virgin 4-day female    7 head, virgin 20-day female    9 head, mated 1-day female    7 head, mated 4-day female    9 head, mated 20-day female    8 head, mated 1-day male    10 head, mated 4-day male    15 head, mated 20-day male    12 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    9 digestive system, 4-day adult    9 digestive system, 20-day adult    6 fat body, larvae L3 wandering    3 fat body, white prepupae    9 fat body, pupae P8    7 carcass, larvae L3 wandering    12 carcass, 1-day adult    7 carcass, 4-day adult    9 carcass, 20-day adult    6 ovary, virgin 4-day female    68 ovary, mated 4-day female    33 testis, mated 4-day male    5 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    21 central nervous system, larvae L3    22 central nervous system, pupae P8    22 head, virgin 1-day female    10 head, virgin 4-day female    7 head, virgin 20-day female    9 head, mated 1-day female    7 head, mated 4-day female    9 head, mated 20-day female    8 head, mated 1-day male    10 head, mated 4-day male    15 head, mated 20-day male    12 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    9 digestive system, 4-day adult    9 digestive system, 20-day adult    6 fat body, larvae L3 wandering    3 fat body, white prepupae    9 fat body, pupae P8    7 carcass, larvae L3 wandering    12 carcass, 1-day adult    7 carcass, 4-day adult    9 carcass, 20-day adult    6 ovary, virgin 4-day female    68 ovary, mated 4-day female    33 testis, mated 4-day male    5 accessory gland, mated 4-day male    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    21 central nervous system, larvae L3    22 central nervous system, pupae P8    22 head, virgin 1-day female    10 head, virgin 4-day female    7 head, virgin 20-day female    9 head, mated 1-day female    7 head, mated 4-day female    9 head, mated 20-day female    8 head, mated 1-day male    10 head, mated 4-day male    15 head, mated 20-day male    12 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    9 digestive system, 4-day adult    9 digestive system, 20-day adult    6 fat body, larvae L3 wandering    3 fat body, white prepupae    9 fat body, pupae P8    7 carcass, larvae L3 wandering    12 carcass, 1-day adult    7 carcass, 4-day adult    9 carcass, 20-day adult    6 ovary, virgin 4-day female    68 ovary, mated 4-day female    33 testis, mated 4-day male    5 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    21 central nervous system, larvae L3    22 central nervous system, pupae P8    22 head, virgin 1-day female    10 head, virgin 4-day female    7 head, virgin 20-day female    9 head, mated 1-day female    7 head, mated 4-day female    9 head, mated 20-day female    8 head, mated 1-day male    10 head, mated 4-day male    15 head, mated 20-day male    12 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    9 digestive system, 4-day adult    9 digestive system, 20-day adult    6 fat body, larvae L3 wandering    3 fat body, white prepupae    9 fat body, pupae P8    7 carcass, larvae L3 wandering    12 carcass, 1-day adult    7 carcass, 4-day adult    9 carcass, 20-day adult    6 ovary, virgin 4-day female  (68) ovary, mated 4-day female  (33) testis, mated 4-day male    5 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    21 central nervous system, larvae L3    22 central nervous system, pupae P8    22 head, virgin 1-day female    10 head, virgin 4-day female    7 head, virgin 20-day female    9 head, mated 1-day female    7 head, mated 4-day female    9 head, mated 20-day female    8 head, mated 1-day male    10 head, mated 4-day male    15 head, mated 20-day male    12 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    9 digestive system, 4-day adult    9 digestive system, 20-day adult    6 fat body, larvae L3 wandering    3 fat body, white prepupae    9 fat body, pupae P8    7 carcass, larvae L3 wandering    12 carcass, 1-day adult    7 carcass, 4-day adult    9 carcass, 20-day adult    6 ovary, virgin 4-day female    68 ovary, mated 4-day female    33 testis, mated 4-day male    5 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    21 central nervous system, larvae L3    22 central nervous system, pupae P8    22 head, virgin 1-day female    10 head, virgin 4-day female    7 head, virgin 20-day female    9 head, mated 1-day female    7 head, mated 4-day female    9 head, mated 20-day female    8 head, mated 1-day male    10 head, mated 4-day male    15 head, mated 20-day male    12 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    9 digestive system, 4-day adult    9 digestive system, 20-day adult    6 fat body, larvae L3 wandering    3 fat body, white prepupae    9 fat body, pupae P8    7 carcass, larvae L3 wandering    12 carcass, 1-day adult    7 carcass, 4-day adult    9 carcass, 20-day adult    6 ovary, virgin 4-day female    68 ovary, mated 4-day female    33 testis, mated 4-day male    5 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-18 hour embryonic stages, during early pupal stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    19 embryo 02-04hr    24 embryo 04-06hr    25 embryo 06-08hr    19 embryo 08-10hr    24 embryo 10-12hr    12 embryo 12-14hr    30 embryo 14-16hr    6 embryo 16-18hr    15 embryo 18-20hr    6 embryo 20-22hr    11 embryo 22-24hr    17 larva L1    5 larva L2    8 larva L3 12hr old    5 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    17 white prepupae new    19 white prepupae 12hr    16 white prepupae 24hr    18 pupae 2d postWPP    15 pupae 3d postWPP    9 pupae 4d postWPP    3 adult male 01day    7 adult male 05day    5 adult male 30day    4 adult female 01day    6 adult female 05day    23 adult female 30day    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    19 embryo 02-04hr    24 embryo 04-06hr    25 embryo 06-08hr    19 embryo 08-10hr    24 embryo 10-12hr    12 embryo 12-14hr  (30) embryo 14-16hr    6 embryo 16-18hr    15 embryo 18-20hr    6 embryo 20-22hr    11 embryo 22-24hr    17 larva L1    5 larva L2    8 larva L3 12hr old    5 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    17 white prepupae new    19 white prepupae 12hr    16 white prepupae 24hr    18 pupae 2d postWPP    15 pupae 3d postWPP    9 pupae 4d postWPP    3 adult male 01day    7 adult male 05day    5 adult male 30day    4 adult female 01day    6 adult female 05day    23 adult female 30day    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    19 embryo 02-04hr    24 embryo 04-06hr    25 embryo 06-08hr    19 embryo 08-10hr    24 embryo 10-12hr    12 embryo 12-14hr    30 embryo 14-16hr    6 embryo 16-18hr    15 embryo 18-20hr    6 embryo 20-22hr    11 embryo 22-24hr    17 larva L1    5 larva L2    8 larva L3 12hr old    5 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    17 white prepupae new    19 white prepupae 12hr    16 white prepupae 24hr    18 pupae 2d postWPP    15 pupae 3d postWPP    9 pupae 4d postWPP    3 adult male 01day    7 adult male 05day    5 adult male 30day    4 adult female 01day    6 adult female 05day    23 adult female 30day    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    19 embryo 02-04hr    24 embryo 04-06hr    25 embryo 06-08hr    19 embryo 08-10hr    24 embryo 10-12hr    12 embryo 12-14hr    30 embryo 14-16hr    6 embryo 16-18hr    15 embryo 18-20hr    6 embryo 20-22hr    11 embryo 22-24hr    17 larva L1    5 larva L2    8 larva L3 12hr old    5 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    17 white prepupae new    19 white prepupae 12hr    16 white prepupae 24hr    18 pupae 2d postWPP    15 pupae 3d postWPP    9 pupae 4d postWPP    3 adult male 01day    7 adult male 05day    5 adult male 30day    4 adult female 01day    6 adult female 05day    23 adult female 30day    14 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    19 embryo 02-04hr    24 embryo 04-06hr    25 embryo 06-08hr    19 embryo 08-10hr    24 embryo 10-12hr    12 embryo 12-14hr    30 embryo 14-16hr    6 embryo 16-18hr    15 embryo 18-20hr    6 embryo 20-22hr    11 embryo 22-24hr    17 larva L1    5 larva L2    8 larva L3 12hr old    5 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    17 white prepupae new    19 white prepupae 12hr    16 white prepupae 24hr    18 pupae 2d postWPP    15 pupae 3d postWPP    9 pupae 4d postWPP    3 adult male 01day    7 adult male 05day    5 adult male 30day    4 adult female 01day    6 adult female 05day    23 adult female 30day    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    19 embryo 02-04hr    24 embryo 04-06hr    25 embryo 06-08hr    19 embryo 08-10hr    24 embryo 10-12hr    12 embryo 12-14hr  30 embryo 14-16hr    6 embryo 16-18hr    15 embryo 18-20hr    6 embryo 20-22hr    11 embryo 22-24hr    17 larva L1    5 larva L2    8 larva L3 12hr old    5 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    17 white prepupae new    19 white prepupae 12hr    16 white prepupae 24hr    18 pupae 2d postWPP    15 pupae 3d postWPP    9 pupae 4d postWPP    3 adult male 01day    7 adult male 05day    5 adult male 30day    4 adult female 01day    6 adult female 05day    23 adult female 30day    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    19 embryo 02-04hr    24 embryo 04-06hr    25 embryo 06-08hr    19 embryo 08-10hr    24 embryo 10-12hr    12 embryo 12-14hr    30 embryo 14-16hr    6 embryo 16-18hr    15 embryo 18-20hr    6 embryo 20-22hr    11 embryo 22-24hr    17 larva L1    5 larva L2    8 larva L3 12hr old    5 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    17 white prepupae new    19 white prepupae 12hr    16 white prepupae 24hr    18 pupae 2d postWPP    15 pupae 3d postWPP    9 pupae 4d postWPP    3 adult male 01day    7 adult male 05day    5 adult male 30day    4 adult female 01day    6 adult female 05day    23 adult female 30day    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    19 embryo 02-04hr    24 embryo 04-06hr    25 embryo 06-08hr    19 embryo 08-10hr    24 embryo 10-12hr    12 embryo 12-14hr    30 embryo 14-16hr    6 embryo 16-18hr    15 embryo 18-20hr    6 embryo 20-22hr    11 embryo 22-24hr    17 larva L1    5 larva L2    8 larva L3 12hr old    5 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    17 white prepupae new    19 white prepupae 12hr    16 white prepupae 24hr    18 pupae 2d postWPP    15 pupae 3d postWPP    9 pupae 4d postWPP    3 adult male 01day    7 adult male 05day    5 adult male 30day    4 adult female 01day    6 adult female 05day    23 adult female 30day    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    54 Schneider line 2 Sg4    21 embryonic 1182-4H    13 embryonic GM2    100 embryonic Kc167    75 embryonic S1    26 embryonic S3    48 leg disc CME L1    12 wing disc CME-W2    50 wing disc ML-DmD8    34 wing disc ML-DmD9    10 wing disc ML-DmD16-c3    22 wing disc ML-DmD21    10 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    44 eye-antennal disc ML-DmD11    46 antennal disc ML-DmD20-c5    19 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    23 CNS ML-DmBG2-c2    38 tumorous blood cells mbn2    84 ovary fGS/OSS    15 ovary OSC    24 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (54) Schneider line 2 Sg4    21 embryonic 1182-4H    13 embryonic GM2  (100) embryonic Kc167  (75) embryonic S1  26 embryonic S3  (48) leg disc CME L1    12 wing disc CME-W2  (50) wing disc ML-DmD8  (34) wing disc ML-DmD9    10 wing disc ML-DmD16-c3    22 wing disc ML-DmD21    10 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3  (44) eye-antennal disc ML-DmD11  (46) antennal disc ML-DmD20-c5    19 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    23 CNS ML-DmBG2-c2  (38) tumorous blood cells mbn2  (84) ovary fGS/OSS    15 ovary OSC    24 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    54 Schneider line 2 Sg4    21 embryonic 1182-4H    13 embryonic GM2    100 embryonic Kc167    75 embryonic S1    26 embryonic S3    48 leg disc CME L1    12 wing disc CME-W2    50 wing disc ML-DmD8    34 wing disc ML-DmD9    10 wing disc ML-DmD16-c3    22 wing disc ML-DmD21    10 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    44 eye-antennal disc ML-DmD11    46 antennal disc ML-DmD20-c5    19 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    23 CNS ML-DmBG2-c2    38 tumorous blood cells mbn2    84 ovary fGS/OSS    15 ovary OSC    24 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    54 Schneider line 2 Sg4    21 embryonic 1182-4H    13 embryonic GM2    100 embryonic Kc167    75 embryonic S1    26 embryonic S3    48 leg disc CME L1    12 wing disc CME-W2    50 wing disc ML-DmD8    34 wing disc ML-DmD9    10 wing disc ML-DmD16-c3    22 wing disc ML-DmD21    10 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    44 eye-antennal disc ML-DmD11    46 antennal disc ML-DmD20-c5    19 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    23 CNS ML-DmBG2-c2    38 tumorous blood cells mbn2    84 ovary fGS/OSS    15 ovary OSC    24 ovary OSS    12 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    54 Schneider line 2 Sg4    21 embryonic 1182-4H    13 embryonic GM2    100 embryonic Kc167    75 embryonic S1    26 embryonic S3    48 leg disc CME L1    12 wing disc CME-W2    50 wing disc ML-DmD8    34 wing disc ML-DmD9    10 wing disc ML-DmD16-c3    22 wing disc ML-DmD21    10 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    44 eye-antennal disc ML-DmD11    46 antennal disc ML-DmD20-c5    19 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    23 CNS ML-DmBG2-c2    38 tumorous blood cells mbn2    84 ovary fGS/OSS    15 ovary OSC    24 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (54) Schneider line 2 Sg4    21 embryonic 1182-4H    13 embryonic GM2  (100) embryonic Kc167  (75) embryonic S1  26 embryonic S3  (48) leg disc CME L1    12 wing disc CME-W2  (50) wing disc ML-DmD8  (34) wing disc ML-DmD9    10 wing disc ML-DmD16-c3    22 wing disc ML-DmD21    10 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3  (44) eye-antennal disc ML-DmD11  (46) antennal disc ML-DmD20-c5    19 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    23 CNS ML-DmBG2-c2  (38) tumorous blood cells mbn2  (84) ovary fGS/OSS    15 ovary OSC    24 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    54 Schneider line 2 Sg4    21 embryonic 1182-4H    13 embryonic GM2    100 embryonic Kc167    75 embryonic S1    26 embryonic S3    48 leg disc CME L1    12 wing disc CME-W2    50 wing disc ML-DmD8    34 wing disc ML-DmD9    10 wing disc ML-DmD16-c3    22 wing disc ML-DmD21    10 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    44 eye-antennal disc ML-DmD11    46 antennal disc ML-DmD20-c5    19 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    23 CNS ML-DmBG2-c2    38 tumorous blood cells mbn2    84 ovary fGS/OSS    15 ovary OSC    24 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    54 Schneider line 2 Sg4    21 embryonic 1182-4H    13 embryonic GM2    100 embryonic Kc167    75 embryonic S1    26 embryonic S3    48 leg disc CME L1    12 wing disc CME-W2    50 wing disc ML-DmD8    34 wing disc ML-DmD9    10 wing disc ML-DmD16-c3    22 wing disc ML-DmD21    10 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    44 eye-antennal disc ML-DmD11    46 antennal disc ML-DmD20-c5    19 mixed discs ML-DmD4-c1    14 CNS ML-DmBG1-c1    23 CNS ML-DmBG2-c2    38 tumorous blood cells mbn2    84 ovary fGS/OSS    15 ovary OSC    24 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    3 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    31 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    49 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    17 Ethanol 5% 3 hrs, larvae L3    10 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    29 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    21 Paraquat 10 mM 48 hrs, 4-day adult    14 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    3 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult  (31) Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult  (49) Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    17 Ethanol 5% 3 hrs, larvae L3    10 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (29) Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    21 Paraquat 10 mM 48 hrs, 4-day adult    14 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    3 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    31 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    49 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    17 Ethanol 5% 3 hrs, larvae L3    10 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    29 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    21 Paraquat 10 mM 48 hrs, 4-day adult    14 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    3 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    31 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    49 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    17 Ethanol 5% 3 hrs, larvae L3    10 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    29 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    21 Paraquat 10 mM 48 hrs, 4-day adult    14 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    3 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    31 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    49 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    17 Ethanol 5% 3 hrs, larvae L3    10 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    29 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    21 Paraquat 10 mM 48 hrs, 4-day adult    14 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    3 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult  31 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult  (49) Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    17 Ethanol 5% 3 hrs, larvae L3    10 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  29 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    21 Paraquat 10 mM 48 hrs, 4-day adult    14 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    3 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    31 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    49 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    17 Ethanol 5% 3 hrs, larvae L3    10 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    29 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    21 Paraquat 10 mM 48 hrs, 4-day adult    14 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    3 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    31 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    49 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    17 Ethanol 5% 3 hrs, larvae L3    10 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    29 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    21 Paraquat 10 mM 48 hrs, 4-day adult    14 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_05 mE1_20_mRNA_expression_cluster_04
External Data & Images
Linkouts	BDGP expression data • LD04986 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0026401 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG17704-RF
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal Nipped-BL5 Nipped-BL7 Nipped-BLa6 Nipped-BLf Nipped-BLL lethal (with Df(2R)M41A2) Nipped-B34-3 Nipped-B45-53 Nipped-B292.1 Nipped-B407 Nipped-B02047 Nipped-Bch(2)54 Nipped-BIR13 Nipped-Bk02601a Nipped-BL5 Nipped-BL7 Nipped-BLa6 Nipped-BLf Nipped-BLL Nipped-BNC6 Nipped-BNC7 Nipped-BNC23 Nipped-BNC39 Nipped-BNC41 Nipped-BNC59 Nipped-BNC60 Nipped-BNC71 Nipped-BNC77 Nipped-BNC78 Nipped-BNC91 Nipped-BNC138 lethal (with Nipped-B34-3) Nipped-B45-53 Nipped-B292.1 Nipped-B407 Nipped-B02047 Nipped-Bch(2)54 Nipped-BIR13 Nipped-Bk02601a Nipped-BL5 Nipped-BL7 Nipped-BLa6 Nipped-BLf Nipped-BLL Nipped-BNC6 Nipped-BNC7 Nipped-BNC23 Nipped-BNC39 Nipped-BNC41 Nipped-BNC59 Nipped-BNC60 Nipped-BNC71 Nipped-BNC77 Nipped-BNC78 Nipped-BNC91 Nipped-BNC138 lethal (with Nipped-B45-53) Nipped-B34-3 Nipped-B292.1 Nipped-B407 Nipped-B02047 Nipped-Bch(2)54 Nipped-BIR13 Nipped-Bk02601a Nipped-BL5 Nipped-BL7 Nipped-BLa6 Nipped-BLf Nipped-BLL Nipped-BNC6 Nipped-BNC7 Nipped-BNC23 Nipped-BNC39 Nipped-BNC41 Nipped-BNC59 Nipped-BNC60 Nipped-BNC71 Nipped-BNC77 Nipped-BNC78 Nipped-BNC91 Nipped-BNC138 lethal (with Nipped-B292.1) Nipped-B34-3 Nipped-B45-53 Nipped-B407 Nipped-B02047 Nipped-Bch(2)54 Nipped-BIR13 Nipped-Bk02601a Nipped-BL5 Nipped-BL7 Nipped-BLa6 Nipped-BLf Nipped-BLL Nipped-BNC6 Nipped-BNC7 Nipped-BNC23 Nipped-BNC39 Nipped-BNC41 Nipped-BNC59 Nipped-BNC60 Nipped-BNC71 Nipped-BNC77 Nipped-BNC78 Nipped-BNC91 Nipped-BNC138 lethal (with Nipped-B407) Nipped-B34-3 Nipped-B45-53 Nipped-B292.1 Nipped-B02047 Nipped-Bch(2)54 Nipped-BIR13 Nipped-Bk02601a Nipped-BL5 Nipped-BL7 Nipped-BLa6 Nipped-BLf Nipped-BLL Nipped-BNC6 Nipped-BNC7 Nipped-BNC23 Nipped-BNC39 Nipped-BNC41 Nipped-BNC59 Nipped-BNC60 Nipped-BNC71 Nipped-BNC77 Nipped-BNC78 Nipped-BNC138 lethal (with Nipped-B02047) Nipped-B34-3 Nipped-B45-53 Nipped-B292.1 Nipped-B407 Nipped-Bch(2)54 Nipped-BIR13 Nipped-Bk02601a Nipped-BL5 Nipped-BL7 Nipped-BLa6 Nipped-BLf Nipped-BLL Nipped-BNC6 Nipped-BNC7 Nipped-BNC23 Nipped-BNC39 Nipped-BNC41 Nipped-BNC59 Nipped-BNC60 Nipped-BNC71 Nipped-BNC77 Nipped-BNC78 Nipped-BNC91 Nipped-BNC138 lethal (with Nipped-Bch(2)54) Nipped-B34-3 Nipped-B45-53 Nipped-B292.1 Nipped-B407 Nipped-B02047 Nipped-BIR13 Nipped-Bk02601a Nipped-BL5 Nipped-BL7 Nipped-BLa6 Nipped-BLf Nipped-BLL Nipped-BNC6 Nipped-BNC7 Nipped-BNC23 Nipped-BNC39 Nipped-BNC41 Nipped-BNC59 Nipped-BNC60 Nipped-BNC71 Nipped-BNC77 Nipped-BNC78 Nipped-BNC91 Nipped-BNC138 lethal (with Nipped-BIR13) Nipped-B34-3 Nipped-B45-53 Nipped-B292.1 Nipped-B407 Nipped-B02047 Nipped-Bch(2)54 Nipped-Bk02601a Nipped-BL5 Nipped-BL7 Nipped-BLa6 Nipped-BLf Nipped-BLL Nipped-BNC6 Nipped-BNC7 Nipped-BNC23 Nipped-BNC39 Nipped-BNC41 Nipped-BNC59 Nipped-BNC60 Nipped-BNC71 Nipped-BNC77 Nipped-BNC78 Nipped-BNC91 Nipped-BNC138 lethal (with Nipped-Bk02601a) Nipped-B34-3 Nipped-B45-53 Nipped-B292.1 Nipped-B407 Nipped-B02047 Nipped-Bch(2)54 Nipped-BIR13 Nipped-BL5 Nipped-BL7 Nipped-BLa6 Nipped-BLf Nipped-BLL Nipped-BNC6 Nipped-BNC7 Nipped-BNC23 Nipped-BNC39 Nipped-BNC41 Nipped-BNC59 Nipped-BNC60 Nipped-BNC71 Nipped-BNC77 Nipped-BNC78 Nipped-BNC91 Nipped-BNC138 lethal (with Nipped-BL5) Nipped-B34-3 Nipped-B45-53 Nipped-B292.1 Nipped-B407 Nipped-B02047 Nipped-Bch(2)54 Nipped-BIR13 Nipped-Bk02601a Nipped-BL7 Nipped-BLa6 Nipped-BLf Nipped-BLL Nipped-BNC6 Nipped-BNC7 Nipped-BNC23 Nipped-BNC39 Nipped-BNC41 Nipped-BNC59 Nipped-BNC60 Nipped-BNC71 Nipped-BNC77 Nipped-BNC78 Nipped-BNC91 Nipped-BNC138 lethal (with Nipped-BL7) Nipped-B34-3 Nipped-B45-53 Nipped-B292.1 Nipped-B407 Nipped-B02047 Nipped-Bch(2)54 Nipped-BIR13 Nipped-Bk02601a Nipped-BL5 Nipped-BLa6 Nipped-BLf Nipped-BLL Nipped-BNC6 Nipped-BNC7 Nipped-BNC23 Nipped-BNC39 Nipped-BNC41 Nipped-BNC59 Nipped-BNC60 Nipped-BNC71 Nipped-BNC77 Nipped-BNC78 Nipped-BNC138 lethal (with Nipped-BLa6) Nipped-B34-3 Nipped-B45-53 Nipped-B292.1 Nipped-B407 Nipped-B02047 Nipped-Bch(2)54 Nipped-BIR13 Nipped-Bk02601a Nipped-BL5 Nipped-BL7 Nipped-BLf Nipped-BLL Nipped-BNC6 Nipped-BNC7 Nipped-BNC23 Nipped-BNC39 Nipped-BNC41 Nipped-BNC59 Nipped-BNC60 Nipped-BNC71 Nipped-BNC77 Nipped-BNC78 Nipped-BNC91 Nipped-BNC138 lethal (with Nipped-BLf) Nipped-B34-3 Nipped-B45-53 Nipped-B292.1 Nipped-B407 Nipped-B02047 Nipped-Bch(2)54 Nipped-BIR13 Nipped-Bk02601a Nipped-BL5 Nipped-BL7 Nipped-BLa6 Nipped-BLL Nipped-BNC6 Nipped-BNC7 Nipped-BNC23 Nipped-BNC39 Nipped-BNC41 Nipped-BNC59 Nipped-BNC60 Nipped-BNC71 Nipped-BNC77 Nipped-BNC78 Nipped-BNC91 Nipped-BNC138 lethal (with Nipped-BLL) Nipped-B34-3 Nipped-B45-53 Nipped-B292.1 Nipped-B407 Nipped-B02047 Nipped-Bch(2)54 Nipped-BIR13 Nipped-Bk02601a Nipped-BL5 Nipped-BL7 Nipped-BLa6 Nipped-BLf Nipped-BNC6 Nipped-BNC7 Nipped-BNC23 Nipped-BNC39 Nipped-BNC41 Nipped-BNC59 Nipped-BNC60 Nipped-BNC71 Nipped-BNC77 Nipped-BNC78 Nipped-BNC91 lethal (with Nipped-BNC6) Nipped-B34-3 Nipped-B45-53 Nipped-B292.1 Nipped-B407 Nipped-B02047 Nipped-Bch(2)54 Nipped-BIR13 Nipped-Bk02601a Nipped-BL5 Nipped-BL7 Nipped-BLa6 Nipped-BLf Nipped-BLL Nipped-BNC7 Nipped-BNC23 Nipped-BNC39 Nipped-BNC41 Nipped-BNC59 Nipped-BNC60 Nipped-BNC71 Nipped-BNC77 Nipped-BNC78 Nipped-BNC91 Nipped-BNC138 lethal (with Nipped-BNC7) Nipped-B34-3 Nipped-B45-53 Nipped-B292.1 Nipped-B407 Nipped-B02047 Nipped-Bch(2)54 Nipped-BIR13 Nipped-Bk02601a Nipped-BL5 Nipped-BL7 Nipped-BLa6 Nipped-BLf Nipped-BLL Nipped-BNC6 Nipped-BNC23 Nipped-BNC39 Nipped-BNC41 Nipped-BNC59 Nipped-BNC60 Nipped-BNC71 Nipped-BNC77 Nipped-BNC78 Nipped-BNC91 Nipped-BNC138 lethal (with Nipped-BNC23) Nipped-B34-3 Nipped-B45-53 Nipped-B292.1 Nipped-B407 Nipped-B02047 Nipped-Bch(2)54 Nipped-BIR13 Nipped-Bk02601a Nipped-BL5 Nipped-BL7 Nipped-BLa6 Nipped-BLf Nipped-BLL Nipped-BNC6 Nipped-BNC7 Nipped-BNC39 Nipped-BNC41 Nipped-BNC59 Nipped-BNC60 Nipped-BNC71 Nipped-BNC77 Nipped-BNC78 Nipped-BNC91 Nipped-BNC138 lethal (with Nipped-BNC39) Nipped-B34-3 Nipped-B45-53 Nipped-B292.1 Nipped-B407 Nipped-B02047 Nipped-Bch(2)54 Nipped-BIR13 Nipped-Bk02601a Nipped-BL5 Nipped-BL7 Nipped-BLa6 Nipped-BLf Nipped-BLL Nipped-BNC6 Nipped-BNC7 Nipped-BNC23 Nipped-BNC41 Nipped-BNC59 Nipped-BNC60 Nipped-BNC71 Nipped-BNC77 Nipped-BNC78 Nipped-BNC91 Nipped-BNC138 lethal (with Nipped-BNC41) Nipped-B34-3 Nipped-B45-53 Nipped-B292.1 Nipped-B407 Nipped-B02047 Nipped-Bch(2)54 Nipped-BIR13 Nipped-Bk02601a Nipped-BL5 Nipped-BL7 Nipped-BLa6 Nipped-BLf Nipped-BLL Nipped-BNC6 Nipped-BNC7 Nipped-BNC23 Nipped-BNC39 Nipped-BNC59 Nipped-BNC60 Nipped-BNC71 Nipped-BNC77 Nipped-BNC78 Nipped-BNC91 Nipped-BNC138 lethal (with Nipped-BNC59) Nipped-B34-3 Nipped-B45-53 Nipped-B292.1 Nipped-B407 Nipped-B02047 Nipped-Bch(2)54 Nipped-BIR13 Nipped-Bk02601a Nipped-BL5 Nipped-BL7 Nipped-BLa6 Nipped-BLf Nipped-BLL Nipped-BNC6 Nipped-BNC7 Nipped-BNC23 Nipped-BNC39 Nipped-BNC41 Nipped-BNC60 Nipped-BNC71 Nipped-BNC77 Nipped-BNC78 Nipped-BNC91 Nipped-BNC138 lethal (with Nipped-BNC60) Nipped-B34-3 Nipped-B45-53 Nipped-B292.1 Nipped-B407 Nipped-B02047 Nipped-Bch(2)54 Nipped-BIR13 Nipped-Bk02601a Nipped-BL5 Nipped-BL7 Nipped-BLa6 Nipped-BLf Nipped-BLL Nipped-BNC6 Nipped-BNC7 Nipped-BNC23 Nipped-BNC39 Nipped-BNC41 Nipped-BNC59 Nipped-BNC71 Nipped-BNC77 Nipped-BNC78 Nipped-BNC91 Nipped-BNC138 lethal (with Nipped-BNC71) Nipped-B34-3 Nipped-B45-53 Nipped-B292.1 Nipped-B407 Nipped-B02047 Nipped-Bch(2)54 Nipped-BIR13 Nipped-Bk02601a Nipped-BL5 Nipped-BL7 Nipped-BLa6 Nipped-BLf Nipped-BLL Nipped-BNC6 Nipped-BNC7 Nipped-BNC23 Nipped-BNC39 Nipped-BNC41 Nipped-BNC59 Nipped-BNC60 Nipped-BNC77 Nipped-BNC78 Nipped-BNC91 Nipped-BNC138 lethal (with Nipped-BNC77) Nipped-B34-3 Nipped-B45-53 Nipped-B292.1 Nipped-B407 Nipped-B02047 Nipped-Bch(2)54 Nipped-BIR13 Nipped-Bk02601a Nipped-BL5 Nipped-BL7 Nipped-BLa6 Nipped-BLf Nipped-BLL Nipped-BNC6 Nipped-BNC7 Nipped-BNC23 Nipped-BNC39 Nipped-BNC41 Nipped-BNC59 Nipped-BNC60 Nipped-BNC71 Nipped-BNC78 Nipped-BNC91 Nipped-BNC138 lethal (with Nipped-BNC78) Nipped-B34-3 Nipped-B45-53 Nipped-B292.1 Nipped-B407 Nipped-B02047 Nipped-Bch(2)54 Nipped-BIR13 Nipped-Bk02601a Nipped-BL5 Nipped-BL7 Nipped-BLa6 Nipped-BLf Nipped-BLL Nipped-BNC6 Nipped-BNC7 Nipped-BNC23 Nipped-BNC39 Nipped-BNC41 Nipped-BNC59 Nipped-BNC60 Nipped-BNC71 Nipped-BNC77 Nipped-BNC91 Nipped-BNC138 lethal (with Nipped-BNC91) Nipped-B34-3 Nipped-B45-53 Nipped-B292.1 Nipped-B02047 Nipped-Bch(2)54 Nipped-BIR13 Nipped-Bk02601a Nipped-BL5 Nipped-BLa6 Nipped-BLf Nipped-BLL Nipped-BNC6 Nipped-BNC7 Nipped-BNC23 Nipped-BNC39 Nipped-BNC41 Nipped-BNC59 Nipped-BNC60 Nipped-BNC71 Nipped-BNC77 Nipped-BNC78 Nipped-BNC138 lethal (with Nipped-BNC138) Nipped-B34-3 Nipped-B45-53 Nipped-B292.1 Nipped-B407 Nipped-B02047 Nipped-Bch(2)54 Nipped-BIR13 Nipped-Bk02601a Nipped-BL5 Nipped-BL7 Nipped-BLa6 Nipped-BLf Nipped-BNC6 Nipped-BNC7 Nipped-BNC23 Nipped-BNC39 Nipped-BNC41 Nipped-BNC59 Nipped-BNC60 Nipped-BNC71 Nipped-BNC77 Nipped-BNC78 Nipped-BNC91 lethal | larval stage | recessive Nipped-B4 Nipped-B292.1 Nipped-B359.1 Nipped-B407 lethal | pupal stage, with Scer\GAL4Act5C.PI Nipped-BdsRNA.Sym.Scer\UAS lethal | recessive Nipped-B34-3 Nipped-B45-53 Nipped-B02047 Nipped-BIR13 Nipped-Bk02601a Nipped-Bk13422a lethal | recessive | second instar larval stage Nipped-B407 Nipped-BNC6 Nipped-BNC7 Nipped-BNC23 Nipped-BNC39 Nipped-BNC41 Nipped-BNC59 Nipped-BNC71 Nipped-BNC77 Nipped-BNC78 viable (with Nipped-B407) Nipped-BNC91 viable (with Nipped-BL7) Nipped-BNC91 viable (with Nipped-BLL) Nipped-BNC138 viable (with Nipped-BNC91) Nipped-B407 Nipped-BL7 viable (with Nipped-BNC138) Nipped-BLL Other Phenotypes Allele mitotic cell cycle defective (with Nipped-B02047) Nipped-BNC6 Nipped-BNC7 Nipped-BNC23 Nipped-BNC39 Nipped-BNC41 Nipped-BNC59 Nipped-BNC71 Nipped-BNC77 Nipped-BNC78 mitotic cell cycle defective (with Nipped-BNC6) Nipped-B02047 mitotic cell cycle defective (with Nipped-BNC7) Nipped-B02047 mitotic cell cycle defective (with Nipped-BNC23) Nipped-B02047 mitotic cell cycle defective (with Nipped-BNC39) Nipped-B02047 mitotic cell cycle defective (with Nipped-BNC41) Nipped-B02047 mitotic cell cycle defective (with Nipped-BNC59) Nipped-B02047 mitotic cell cycle defective (with Nipped-BNC71) Nipped-B02047 mitotic cell cycle defective (with Nipped-BNC77) Nipped-B02047 mitotic cell cycle defective (with Nipped-BNC78) Nipped-B02047 Phenotype manifest in Allele adult abdomen, with Scer\GAL4da.G32 Nipped-BScer\UAS.T:Zzzz\FLAG male genitalia, with Scer\GAL4da.G32 Nipped-BScer\UAS.T:Zzzz\FLAG synaptonemal complex Nipped-B292.1 Nipped-B359.1 Nipped-B407 Nipped-B10E
Classical Alleles ( 30 )
For All Classical Alleles Show
Allele of Nipped-B Class Mutagen Stocks Known lesion Nipped-B02047 P-element activity 1 Yes Nipped-BNC138 ethyl methanesulfonate 1 -- Nipped-B10E loss of function allele P-element activity 0 Yes Nipped-B292.1 loss of function allele gamma ray 0 -- Nipped-B29 0 -- Nipped-B34-3 ethyl methanesulfonate 0 Yes Nipped-B359.1 loss of function allele gamma ray 0 -- Nipped-B407 loss of function allele gamma ray 0 -- Nipped-B45-53 ethyl methanesulfonate 0 Yes Nipped-B4 loss of function allele gamma ray 0 -- Nipped-Bch(2)54 P-element activity 0 -- Nipped-BIR13 IR-hybrid dysgenesis 0 -- Nipped-Bk02601a P-element activity 0 -- Nipped-Bk13422a P-element activity 0 -- Nipped-BL5 ethyl methanesulfonate 0 -- Nipped-BL7 ethyl methanesulfonate 0 -- Nipped-BLa6 ethyl methanesulfonate 0 -- Nipped-BLf ethyl methanesulfonate 0 -- Nipped-BLL ethyl methanesulfonate 0 -- Nipped-BNC23 ethyl methanesulfonate 0 Yes Nipped-BNC39 ethyl methanesulfonate 0 Yes Nipped-BNC41 ethyl methanesulfonate 0 Yes Nipped-BNC59 ethyl methanesulfonate 0 Yes Nipped-BNC60 ethyl methanesulfonate 0 -- Nipped-BNC6 ethyl methanesulfonate 0 Yes Nipped-BNC71 ethyl methanesulfonate 0 Yes Nipped-BNC77 ethyl methanesulfonate 0 Yes Nipped-BNC78 ethyl methanesulfonate 0 Yes Nipped-BNC7 ethyl methanesulfonate 0 Yes Nipped-BNC91 0 --
Alleles Carried on Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Nipped-B Class Mutagen Stocks Known lesion Nipped-BGL00574 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Nipped-BHM05172 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Nipped-BHMS00401 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Nipped-BChi.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Nipped-BChi.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Nipped-BdsRNA.Sym.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes Nipped-BNIG.17704R in vitro construct - RNAi in vitro construct - regulatory fusion 0 -- Nipped-BScer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)M41A2 (Myster et al., 2004, Myster et al., 2004, Coulthard et al., 2010, Coulthard et al., 2010) Df(2R)M41A4 (Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(2R)M41A8 (Rollins et al., 1999, Myster et al., 2004, Myster et al., 2004, Gambetta and Mueller, 2009.8.18) Df(2R)M41A10 (Rollins et al., 1999, Corradini et al., 2003, Myster et al., 2004, Myster et al., 2004, Gambetta and Mueller, 2009.8.18) Df(2R)nap13 (BDGP Project Members, 1994-1999) Df(2R)NC13 (Myster and Peifer, 2003.9.11, Myster et al., 2004) Df(2R)NC50 (Myster et al., 2004) Df(2R)NC68 (Myster et al., 2004) Df(2R)NC125 (Myster et al., 2004) Df(2R)NC167 (Myster et al., 2004) Df(2R)NC191 (Myster et al., 2004) Df(2R)NC202 (Myster et al., 2004) Df(2R)NC218 (Myster et al., 2004) Df(2R)NC228 (Myster and Peifer, 2003.9.11, Myster et al., 2004) Df(2R)Nipped-AC25 (Rollins et al., 1999) Df(2R)Nipped-C160.1 (Rollins et al., 1999) Df(2R)Nipped-D (Myster et al., 2004, Myster et al., 2004) Df(2R)Nipped-D263.3 (Rollins et al., 1999) Df(2R)Nipped-D341.1 (Rollins et al., 1999) Df(2R)Nipped-E43 (Rollins et al., 1999) Df(2R)Nipped-E299.1 (Rollins et al., 1999) Df(2R)Nipped-E338 (Rollins et al., 1999) T(2;3)Nipped-B4 (Rollins et al., 1999) T(2;3)Nipped-B359.1 (Rollins et al., 1999) T(2;3)Nipped-C138.2 (Rollins et al., 1999)
Not disrupted in	Df(2L)C' (BDGP Project Members, 1994-1999) Df(2L)TW161 (BDGP Project Members, 1994-1999) Df(2R)34-2 (Coulthard et al., 2010) Df(2R)244 (Myster et al., 2004) Df(2R)247 (Myster et al., 2004) Df(2R)Dark2 (Myster et al., 2004) Df(2R)nap1 (Myster et al., 2004, Gambetta and Mueller, 2009.8.18) Df(2R)nap4 (Gambetta and Mueller, 2009.8.18) Df(2R)nap8 (Gambetta and Mueller, 2009.8.18) Df(2R)nap11 (Gambetta and Mueller, 2009.8.18) Df(2R)NC32 (Myster et al., 2004, Gambetta and Mueller, 2009.8.18) Df(2R)NC73 (Myster et al., 2004) Df(2R)NC98 (Myster et al., 2004) Df(2R)NC168 (Myster et al., 2004) Df(2R)NC195 (Myster et al., 2004) Df(2R)NC207 (Myster et al., 2004) Df(2R)NC219 (Myster et al., 2004) Df(2R)NC1198 (Myster et al., 2004) Df(2R)rl-10G (Rollins et al., 1999)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{Sym-UAS-Nipped-B} NA P{TRiP.GL00574} NA P{TRiP.HM05172} NA P{TRiP.HMS00401} NA P{UAS-Nipped-B.FLAG} NA characterization construct P{Chi-Nipped-B.FLAG} NA P{Chi-Nipped-B-EGFP} NA P{NIG.17704R} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}Nipped-Bk02601a No P{lacW}Nipped-Bk13422a No P{PZ}Nipped-B02047 No P{PZ}Nipped-Bch(2)54 No
Gene Ontology: Function, Process & Cellular Component ( 13 unique terms )
Terms Based on Experimental Evidence ( 13 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with CG4203 (Seitan et al., 2006)
Biological Process
CV term Evidence References
mitotic sister chromatid cohesion inferred from mutant phenotype (Rollins et al., 2004, Gause et al., 2008) positive regulation of gene expression inferred from genetic interaction with hh (Hallson et al., 2008) inferred from mutant phenotype (Gause et al., 2008) regulation of transcription, DNA-dependent inferred from mutant phenotype (assigned by UniProtKB) (Rollins et al., 2004) synaptonemal complex organization inferred from mutant phenotype (Gause et al., 2008) transcriptional activation by promoter-enhancer looping inferred from genetic interaction with ct (Rollins et al., 1999)
Cellular Component
CV term Evidence References
colocalizes_with cohesin complex inferred from direct assay (Gause et al., 2010, Gause et al., 2008) nucleoplasm inferred from direct assay (Gause et al., 2010) nucleus inferred from direct assay (Rollins et al., 2004, Gause et al., 2008) polytene chromosome inferred from direct assay (Gause et al., 2008) protein complex inferred from direct assay (Gause et al., 2008) colocalizes_with synaptonemal complex inferred from direct assay (Gause et al., 2008) transcriptionally active chromatin inferred from direct assay (Misulovin et al., 2008)
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Nipped-B - Pk17E anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Nipped-B - kay anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Nipped-B allele Gene References Nipped-B4 ct (Rollins et al., 1999) mam (Rollins et al., 1999) Nipped-B292.1 ct (Rollins et al., 1999) mam (Rollins et al., 1999) N (Rollins et al., 1999) Ubx (Rollins et al., 1999) Nipped-B359.1 ct (Rollins et al., 1999) Nipped-B407 ct (Rollins et al., 1999) N (Rollins et al., 1999) Ubx (Rollins et al., 1999) unspecified vg (Rollins et al., 1999)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 78261 DroID - A comprehensive database of gene and protein interactions. • FBgn0026401 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 3355136
Orthologs
OrthoDB Orthologs (41) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6X0NBM Dipteran inclusive ortholog search EOG6K3M45 Insect inclusive ortholog search EOG6280WD Arthropod inclusive ortholog search EOG6M0CGG Metazoa inclusive ortholog search EOG6Z6FF4
Orthologs in Drosophila Species (EOG6X0NBM)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Nipped-B     Drosophila sechellia   Dsec\GM13622     Drosophila erecta   Dere\GG21418     Drosophila yakuba   Dyak\GE18632     Drosophila pseudoobscura pseudoobscura   Dpse\GA27714     Drosophila persimilis   Dper\GL18991     Drosophila willistoni   Dwil\GK18592     Drosophila willistoni   Dwil\GK18593     Drosophila mojavensis   Dmoj\GI18280     Drosophila grimshawi   Dgri\GH13548
Orthologs in non-Drosophila Dipterans (EOG6K3M45)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL007242   Anopheles gambiae Malaria mosquito  Agam\AGAP009290   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ012525
Orthologs in non-Dipteran Insects (EOG6280WD)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB44252   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG014336   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH11689   Atta cephalotes Leafcutter ant  Acep\ACEP18969   Camponotus floridanus Florida carpenter ant  Cflo\CFLO23005   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL23403   Linepithema humile Argentine ant  Lhum\LH16073   Pogonomyrmex barbatus Red harvester ant  Pbar\PB20959   Pogonomyrmex barbatus Red harvester ant  Pbar\PB23398   Solenopsis invicta Red fire ant  Sinv\SINV17780   Acyrthosiphon pisum Pea aphid  Apim\ACYPI005925   Bombyx mori Silkmoth  Bmor\BGIBMGA006830   Pediculus humanus Human body louse  Phum\PHUM035670   Tribolium castaneum Red flour beetle  Tcas\TC004719
Orthologs in non-Insect Arthropods (EOG6M0CGG)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_221684   Ixodes scapularis Deer tick  Isca\ISCW005186
Orthologs in non-Arthropod Metazoa (EOG6Z6FF4)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\pqn-85   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_025723gn   Danio rerio Zebrafish  Drer\nipblb   Danio rerio Zebrafish  Drer\si:ch73-311f13.1   Danio rerio Zebrafish  Drer\nipbla   Xenopus tropicalis Western clawed frog  Xtro\nipbl   Gallus gallus Domestic chicken  Ggal\ENSGALG00000013312   Gallus gallus Domestic chicken  Ggal\NIPBL   Gallus gallus Domestic chicken  Ggal\ENSGALG00000021294   Mus musculus House mouse  Mmus\Nipbl   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000025680   Homo sapiens Human  Hsap\ENSG00000164190
Human Orthologs (1)
Gene OMIM HGNC Hsap\ENSG00000164190
AAA Orthologs (0) based on analysis using Dmel annotation version 4.3
No orthologs identified
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	7163 Nipped-BNC138 cn1 bw1/SM1 32406 y1 sc* v1; P{TRiP.HMS00401}attP2 36614 y1 sc* v1; P{TRiP.GL00574}attP40 11143 P{PZ}Nipped-B02047 cn1/CyO; ry506 28961 y1 v1; P{TRiP.HM05172}attP2/TM3, Sb1
Genomic Clones ( 1 )
	BACR15A11 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 150 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD02874 LD10860 RE31579
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RE10040 RE67424 RE69490 RE69635 RH39952
Other clones	612 9803 11477 11576 13285 18799 19226 19442 30227 30882 34651 39323 61764 63264 65056 65237 67471 83105 97048 99038 99186 100415 103164 103370 104669 104718 105474 118983 121806 153893 153914 156720 162345 182094 211084.2 214321.37 214347.34 214403.42 280679 527911 528115 542632 bs52b03 CK01.16B.E8 CK01.21D.E12 CK01.22B.E7 CK01.23D.A1 CK01.25D.D11 CK01.27B.D10 CK01.30C.G2 CK01.34B.B4 CK01.34C.B6 CK01.57A.F10 CK01.72C.D11 CK01.88B.C3 CK01.102A.B12 CK01.110B.C12 CK01.112D.E9 CK01.143B.G2 Dmel_dig_002368_0596_3719 Dmel_dig_005585_0663_3653 Dmel_dig_007616_0670_3604 Dmel_neb_009845_0658_0413 Dmel_neb_013471_0825_3162 Dmel_neb_014274_0594_0604 EC39380 EK001819 EK020520 EK020939 EK021501 EK022716 EK026757 EK029129 EK039264 EK043925 EK046241 EK054521 EK057514 EK060705 EK069510 EK082235 EK087835 EK088606 EK102332 EK105806 EK107627 EK109427 EK112121 EK115147 EK116357 EK121847 EK128908 EK133745 EK138724 EK140356 EK144839 EK152740 EK164536 EK170315 EK188953 EK191545 EK192426 EK196125 EK197803 EK199501 EK216938 EK219312 EK221324 EK222843 EK227916 EK229540 EK229645 EK241921 EK257423 EK257461 EK259620 EK265738 EK290442 EK290546 EK292027 EK301708 EK304206 EK305521 EN03106 EN08029 EN08548 EN11014 EP00638 EP15742 FGA008E04 FGM316G08 IP04939 LD04986 RP003081910 RP003125836 RP003198693 RP003240915 RP003251067 RP003268557 RP003271671 RP003272306 RP003392985
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0026401 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 3355136
Antibody Information
	polyclonal (Gause et al., 2008, Rollins et al., 2004)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Nipped-B l(2)02047 (Rollins et al., 1999)
Additional comments	'Nipped' mutations disrupt one or more of four recessive lethal complementation groups: l(2)41Ae, RpL38, Nipped-A and Nipped-B. (Rollins et al., 1999)
Other Comments
	Transiently named CG40281 in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003) 'Nipped' mutations identify four essential complementation groups, l(2)41Ae, RpL38, Nipped-A and Nipped-B, that play distinct roles in regulating ct and N signalling. (Rollins et al., 1999) The Nipped-B protein may function architecturally between enhancers and promoters to facilitate enhancer-promoter interactions. (Rollins et al., 1999) Nipped-B influences N receptor signalling or N expression primarily during development of the eye. Nipped-B is particularly antagonistic to the insulator activity of Su(H). (Rollins et al., 1999) The Nipped-group genes regulate ct and Ubx. (Rollins et al., 1997) "G00522; BDGP:Dm0206; BDGP:l(2)02047" was stated as revision.
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_001042986 NM_001042987 NM_001169581 NM_001169582 NM_001169583 NM_001273774 RefSeq (Proteins) • NP_001036451 NP_001036452 NP_001163052 NP_001163053 NP_001163054 NP_001260703 DDBJ / EMBL / GenBank • AABU01002769 AAD26161 ACZ94332 ACZ94333 ACZ94334 AF114160 AGB93238 EAA46003 EAA46004 G00522 Entrez Gene - A searchable database of RefSeq genes. • 3355136 UniProtKB/Swiss-Prot • Q7PLI2 UniProtKB/TrEMBL • E1JGX3
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Sister chromatid cohesion C-terminal domain (IPR024986) Armadillo-type fold (IPR016024) Armadillo-like helical (IPR011989) HEAT repeat associated with sister chromatid cohesion protein (IPR026003) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD04986
Linkouts
	BioGRID - A database of protein and genetic interactions • 78261 DroID - A comprehensive database of gene and protein interactions. • FBgn0026401 DRSC - Results from RNAi screens. • FBgn0026401 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0026401 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG17704-RF FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0026401 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 3355136 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /genebrief/nipped-b.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 3355136 modMine - Data generated by the modENCODE project. • FBgn0026401
Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym	CG17704 (Dimitri et al., 2005, Labourier et al., 2002, Ni et al., 2011.7.19, Perkins et al., 2009, Ni et al., 2010.12.1) CG40281 (Giot et al., 2003, ) l(2)02047 (Spradling et al., 1999, Jackle and Janning, 1998.8.10, BDGP Project Members, 1994-1999, ) NipB (Gause et al., 2008) Nipped-B (Rossi et al., 2007, Dorsett et al., 2005, Pauli et al., 2007, Dimitri et al., 2003, Kharchenko et al., 2011, Fay et al., 2011, Kallappagoudar et al., 2010, Dimitri et al., 2003, Misulovin et al., 2008, Gause et al., 2008, Hallson et al., 2008, Rollins et al., 2004, Seitan et al., 2006, Macalpine et al., 2010, Coulthard et al., 2010, Rhodes et al., 2010, Di Stefano et al., 2011, Wasbrough et al., 2010, Fasulo et al., 2012, Antao et al., 2012, Cunningham et al., 2012) nipped-B (Zhang et al., 2011)
Name Synonym	Nipped (Rollins et al., 1997) Nipped B (Geyer and Clark, 2002, Choo, 2001) Nipped-B (Dorsett et al., 2005, Rollins et al., 2004, Schaaf et al., 2009, Gambetta and Mueller, 2009.8.18, Seitan et al., 2006, Macalpine et al., 2010, Rhodes et al., 2010, Gause et al., 2010)
Secondary FlyBase IDs
	FBan0017704 FBgn0010505 FBgn0020393 FBgn0058281
References ( 78 )
Generate a list of	All references relating to this gene ( 78 )
List References by type	Research paper  ( 34 ) Supplementary material  ( 5 ) Review  ( 15 ) Personal communication to FlyBase  ( 14 ) Abstract  ( 7 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 1 ) Website  ( 1 )
Recent research papers ( 9 )
	Antao et al., 2012, Mol. Cell. Biol. 32(12): 2170--2182 Protein Landscape at Drosophila melanogaster Telomere-Associated Sequence Repeats. [FBrf0218429] Baradaran-Heravi et al., 2012, Hum. Mol. Genet. 21(11): 2572--2587 Penetrance of biallelic SMARCAL1 mutations is associated with environmental and genetic disturbances of gene expression. [FBrf0218299] Cunningham et al., 2012, Development 139(22): 4172--4179 Wapl antagonizes cohesin binding and promotes Polycomb-group silencing in Drosophila. [FBrf0219747] Fasulo et al., 2012, PLoS Genet. 8(8): e1002878 The Drosophila MI-2 chromatin-remodeling factor regulates higher-order chromatin structure and cohesin dynamics in vivo. [FBrf0219217] Krauchunas et al., 2012, Dev. Biol. 370(1): 125--134 Protein phosphorylation changes reveal new candidates in the regulation of egg activation and early embryogenesis in D. melanogaster. [FBrf0219342] Di Stefano et al., 2011, Genes Dev. 25(1): 17--28 Functional antagonism between histone H3K4 demethylases in vivo. [FBrf0212709] Fay et al., 2011, Curr. Biol. 21(19): 1624--1634 Cohesin selectively binds and regulates genes with paused RNA polymerase. [FBrf0216412] Kharchenko et al., 2011, Nature 471(7339): 480--485 Comprehensive analysis of the chromatin landscape in Drosophila melanogaster. [FBrf0213294] Zhang et al., 2011, Chromosoma 120(1): 97--108 Drosophila melanogaster heterochromatin protein HP1b plays important roles in transcriptional activation and development. [FBrf0212898] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...