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General Information
Symbol
Dmel\Dronc
Species
D. melanogaster
Name
Death regulator Nedd2-like caspase
Annotation Symbol
CG8091
Feature Type
FlyBase ID
FBgn0026404
Gene Model Status
Stock Availability
Gene Snapshot
Death regulator Nedd2-like caspase (Dronc) encodes an initiator caspase that is essential for caspase-dependent cell death. It is also implicated in the DNA damage response, sperm differentiation and cell specification. [Date last reviewed: 2018-10-18]
Also Known As

Nc, Nedd2-like caspase, caspase-9

Key Links
Genomic Location
Cytogenetic map
Sequence location
3L:9,968,479..9,971,002 [+]
Recombination map

3-32

RefSeq locus
NT_037436 REGION:9968479..9971002
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the peptidase C14A family. (Q9XYF4)
Summaries
Gene Group (FlyBase)
APOPTOSOME -
The apoptosome is a ring-like multisubunit complex assembled upon receiving a pro-apoptotic signal. In Drosophila, Dark assembles into two stacked rings of eight subunits each. This scaffold binds ADP and an initiator caspase (Dronc in D.mel) which cleaves effector caspase(s). (Adapted from FBrf0212736).
CASPASES -
Caspases are a family of cysteine proteases that are particularly well known for their role in apoptosis. Caspases are translated as inactive zymogen precursor proteins. Initiator caspases have a large prodomain, and are cleaved to yield active enzyme in response to proapoptotic stimuli. Initiator caspases cleave and active effector (or executioner) caspases which cleave the substrates leading to programmed cell death. (Adapted from FBrf0215539).
Protein Function (UniProtKB)
Involved in the activation cascade of caspases responsible for apoptosis execution. Effector of steroid-mediated apoptosis during insect metamorphosis. Overexpression promotes programmed cell death. Interaction with Diap1 is required to suppress Dronc-mediated cell death; via Diap1-mediated ubiquitination of Dronc. Rate-limiting caspase in rpr and hid death pathway.
(UniProt, Q9XYF4)
Summary (Interactive Fly)

cysteine protease - a functional homolog of CED-3/caspase-9 - initiator caspase - involved in programmed cell death - activated by interaction with the Apaf-containing apoptosome

Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\Dronc or the JBrowse view of Dmel\Dronc for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.45

Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0076347
2015
450
Additional Transcript Data and Comments
Reported size (kB)

2.2 (northern blot)

Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0076076
51.1
450
7.07
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)

450 (aa); 50 (kD observed)

Comments
External Data
Subunit Structure (UniProtKB)

Interacts with Diap1; residues 114-125 interact with the second BIR domain of Diap1. Can form a stable complex with Drice. Rpr can out-compete Dronc for binding Diap1, therefore removing Diap1-mediated ubiquitination.

(UniProt, Q9XYF4)
Post Translational Modification

Ubiquitinated by Diap1, leading to its subsequent degradation.

(UniProt, Q9XYF4)
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Dronc using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Gene Ontology (37 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
inferred from sequence model
inferred from sequence or structural similarity with WB:WBGene00000417
Biological Process (27 terms)
Terms Based on Experimental Evidence (25 terms)
CV Term
Evidence
References
inferred from genetic interaction with FLYBASE:Diap1; FB:FBgn0260635
inferred from physical interaction with FLYBASE:Diap1; FB:FBgn0260635
inferred from expression pattern
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:Ca-β; FB:FBgn0259822
inferred from direct assay
inferred from direct assay
inferred from genetic interaction with FLYBASE:Atg1; FB:FBgn0260945
inferred from mutant phenotype
inferred from mutant phenotype
inferred from direct assay
inferred from mutant phenotype
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
Cellular Component (5 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
inferred from direct assay
inferred from direct assay
inferred from direct assay
inferred from direct assay
Terms Based on Predictions or Assertions (0 terms)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
organism

Comment: maternally deposited

northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data

Dronc transcripts are detected in all developmental stages on northern blots. Dronc transcripts are ubiquitously distributed in early embryos and are seen at reduced levels at later stages. High Dronc transcript levels are observed in salivary glands and midgut in late third instar larvae but not second instar larvae. Low levels of Dronc transcripts are observed throughout third instar eye discs and brain lobes. Dronc expression is also observed in egg chambers. Dronc expression is induced by ecdysone.

Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
salivary gland

Comment: reference states 12-14h APF

Malpighian tubule

Comment: reference states 12-14h APF

Additional Descriptive Data

Processing of the full-length Dronc precursor transcript (50 kDa) differs between pupal and larval salivary gland and Malpighian tubule tissue. Only the pupal salivary gland shows a band of activated Dronc at 19 kDa, and almost no full-length protein remaining.

Expression of Dronc protein is observed in fully elongated spermatid cysts, and is depleted from individualized spermatozoa.

Marker for
 
Subcellular Localization
CV Term
Evidence
References
inferred from direct assay
inferred from direct assay
inferred from direct assay
inferred from direct assay
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Dronc in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 23 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 43 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Dronc
Transgenic constructs containing regulatory region of Dronc
Deletions and Duplications ( 6 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
neuroblast & larval abdominal segment 3 | late third instar larval stage
neuroblast & larval abdominal segment 4 | late third instar larval stage
neuroblast & larval abdominal segment 5 | late third instar larval stage
neuroblast & larval abdominal segment 6 | late third instar larval stage
neuroblast & larval abdominal segment 7 | late third instar larval stage
neuron & ventral nerve cord | ectopic (with Dronc51)
neuron & ventral nerve cord | ectopic (with DroncI24)
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (21)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
5 of 15
Yes
Yes
4 of 15
No
Yes
3 of 15
No
Yes
 
3 of 15
No
Yes
3 of 15
No
Yes
3 of 15
No
No
3 of 15
No
No
2 of 15
No
No
 
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
 
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (13)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
5 of 15
Yes
Yes
3 of 15
No
Yes
3 of 15
No
Yes
3 of 15
No
No
3 of 15
No
Yes
3 of 15
No
Yes
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (13)
5 of 13
Yes
Yes
4 of 13
No
Yes
3 of 13
No
Yes
3 of 13
No
No
3 of 13
No
Yes
2 of 13
No
No
2 of 13
No
Yes
2 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
Yes
1 of 13
No
No
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (9)
5 of 12
Yes
Yes
2 of 12
No
Yes
2 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
Yes
Danio rerio (Zebrafish) (24)
4 of 15
Yes
Yes
4 of 15
Yes
Yes
3 of 15
No
Yes
3 of 15
No
No
3 of 15
No
Yes
3 of 15
No
Yes
3 of 15
No
Yes
3 of 15
No
Yes
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
Yes
2 of 15
No
No
2 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (5)
5 of 15
Yes
No
 
3 of 15
No
No
2 of 15
No
No
2 of 15
No
No
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190CAQ )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091504J6 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0KGE )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Nasonia vitripennis
Parasitic wasp
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Tribolium castaneum
Red flour beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Acyrthosiphon pisum
Pea aphid
Acyrthosiphon pisum
Pea aphid
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0KMS )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Strigamia maritima
European centipede
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0XCA )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Ciona intestinalis
Vase tunicate
Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (6)
4 of 10
4 of 10
3 of 10
3 of 10
2 of 10
2 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 2 )
Allele
Disease
Evidence
References
Potential Models Based on Orthology ( 0 )
Human Ortholog
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 3 )
Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Interactions
Summary of Physical Interactions
esyN Network Diagram
Show neighbor-neighbor interactions:
Select Layout:
Legend:
Protein
RNA
Selected Interactor(s)
Interactions Browser

Please see the Physical Interaction reports below for full details
protein-protein
Physical Interaction
Assay
References
Summary of Genetic Interactions
esyN Network Diagram
esyN Network Key:
Suppression
Enhancement

Please look at the allele data for full details of the genetic interactions
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
External Data
Subunit Structure (UniProtKB)
Interacts with Diap1; residues 114-125 interact with the second BIR domain of Diap1. Can form a stable complex with Drice. Rpr can out-compete Dronc for binding Diap1, therefore removing Diap1-mediated ubiquitination.
(UniProt, Q9XYF4 )
Linkouts
BioGRID - A database of protein and genetic interactions.
DroID - A comprehensive database of gene and protein interactions.
InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
Pathways
Signaling Pathways (FlyBase)
Metabolic Pathways
External Data
Linkouts
KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
Genomic Location and Detailed Mapping Data
Chromosome (arm)
3L
Recombination map

3-32

Cytogenetic map
Sequence location
3L:9,968,479..9,971,002 [+]
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
67D2-67D2
Limits computationally determined from genome sequence between P{PZ}fry02240 and P{lacW}l(3)L0539L0539&P{PZ}Dhh1rL562
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Stocks and Reagents
Stocks (21)
Genomic Clones (17)
 

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (75)
 

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequences
BDGP DGC clones
Other clones
Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)
RNAi and Array Information
Linkouts
DRSC - Results frm RNAi screens
GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
Antibody Information
Laboratory Generated Antibodies
Commercially Available Antibodies
 
Other Information
Relationship to Other Genes
Source for database identify of

Source for identity of: Nc CG8091

Source for identity of: Dronc Nc

Source for database merge of

Source for merge of: Nc anon- EST:GressD6

Source for merge of: Nc anon-WO0118547.313

Additional comments

Changed from 'Nc' to 'Dronc' to reflect common usage in the literature.

Source for merge of Nc anon- EST:GressD6 was sequence comparison ( date:030707 ).

Source for merge of Nc anon-WO0118547.313 was sequence comparison ( date:051113 ).

Other Comments

Nc has a role in the coordination of tissue growth; when growth rate is reduced in a specific territory in the developing wing disc, Nc reduces cell proliferation rates in adjacent cell populations.

Nc activity has a negative effect on border follicle cell migration.

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

Area matching Drosophila EST AA540020.

Nc cleaves tetrapeptide and protein substrates carboxy-terminal to glutamate as well as aspartate residues.

th interacts with the pro-domain of Nc and appears to be a critical regulator of activation of Nc in vivo. Nc appears to act in the rpr and W pathway.

Loss of Nc function in early embryos results in a dramatic decrease in cell death in the embryos.

Origin and Etymology
Discoverer
Etymology
Identification
External Crossreferences and Linkouts ( 56 )
Sequence Crossreferences
NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
Other crossreferences
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
KEGG Genes - Molecular building blocks of life in the genomic space.
modMine - A data warehouse for the modENCODE project
Linkouts
BioGRID - A database of protein and genetic interactions.
DPiM - Drosophila Protein interaction map
DroID - A comprehensive database of gene and protein interactions.
DRSC - Results frm RNAi screens
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
FlyMine - An integrated database for Drosophila genomics
Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
Synonyms and Secondary IDs (18)
Reported As
Symbol Synonym
Dronc
(Asri et al., 2019, Jiang et al., 2019, Khan et al., 2019, Meltzer et al., 2019, Pinal et al., 2019, Snigdha et al., 2019, Tang, 2019, Tettamanti and Casartelli, 2019, Wu et al., 2019, Yan et al., 2019, Yuan et al., 2019, Ahmed-de-Prado and Baonza, 2018, Ahmed-de-Prado et al., 2018, Akai et al., 2018, Baena-Lopez et al., 2018, Chi et al., 2018, Diwanji and Bergmann, 2018, Dorstyn et al., 2018, Mlih et al., 2018, Mondal et al., 2018, Ren et al., 2018, Verghese and Su, 2018, Xu et al., 2018, Diwanji and Bergmann, 2017, Kamber Kaya et al., 2017, Khan et al., 2017, Kutscher and Shaham, 2017, Nainu et al., 2017, Nakajima and Kuranaga, 2017, Schott et al., 2017, Suisse et al., 2017, Transgenic RNAi Project members, 2017-, Baker and Kale, 2016, Bhogal et al., 2016, Chen et al., 2016, Dabrowska et al., 2016, Eroglu and Derry, 2016, Kawamoto et al., 2016, Koerver et al., 2016, Lee et al., 2016, Melzer and Broemer, 2016, Padash Barmchi et al., 2016, Qi et al., 2016, Yaniv and Schuldiner, 2016, Zheng et al., 2016, Arya and White, 2015, Denton and Kumar, 2015, Di Cara et al., 2015, Dwivedi et al., 2015, Enomoto et al., 2015, Guntermann et al., 2015, Legent et al., 2015, Means et al., 2015, Reitman et al., 2015, Sakamaki et al., 2015, Su, 2015, Bertet et al., 2014, Griciuc et al., 2014, Huang et al., 2014, Liu et al., 2014, Nandi et al., 2014, Robbins et al., 2014, Steller et al., 2014.7.9, Yang et al., 2014, Christiansen et al., 2013, D'Brot et al., 2013, Denton et al., 2013, Dick and Megeney, 2013, Jenkins et al., 2013, Lee et al., 2013, Liu et al., 2013, Liu et al., 2013, Pérez-Garijo et al., 2013, Rallis et al., 2013, Yuan and Akey, 2013, Zhang and Cohen, 2013, Chen et al., 2012, Darding and Meier, 2012, Domingues and Ryoo, 2012, Fabian and Brill, 2012, Filipiak et al., 2012, Kanao et al., 2012, Ma et al., 2012, Marchal et al., 2012, Miura, 2012, Pushpavalli et al., 2012, Vecchio et al., 2012, Verghese et al., 2012, Keller et al., 2011, Kuranaga, 2011, Li et al., 2011, Miura, 2011, Morata et al., 2011, Ouyang et al., 2011, Rumpf et al., 2011, Suissa et al., 2011, Tao and Rolls, 2011, Yuan et al., 2011, Bergantiños et al., 2010, Kanao et al., 2010, Kim et al., 2010, Mesquita et al., 2010, Paquette et al., 2010, Yang et al., 2010, Glavic et al., 2009, Koto et al., 2009, Liu et al., 2009, Ribaya et al., 2009, Cakouros et al., 2008, Caldwell et al., 2008, Domingues and Ryoo, 2008, Fan and Bergmann, 2008, Lee et al., 2008, Li and Cadigan, 2008, Pret et al., 2008, Tsujimura et al., 2008, Baum et al., 2007, Caldwell and Eberl, 2007, Chandraratna et al., 2007, Chew et al., 2007, Copeland et al., 2007, Fan and Bergmann, 2007, Herman-Bachinsky et al., 2007, Huh et al., 2007, Kim and Yoo, 2007, Kuranaga and Miura, 2007, Link et al., 2007, McCall et al., 2007, Primrose et al., 2007, Shin and Yoo, 2007, Takemoto et al., 2007, Tenev et al., 2007, Wu et al., 2007, Yi et al., 2007, Baehrecke, 2006, Bergman, 2006.7.7, Bergmann, 2006, Kuo et al., 2006, Mendes et al., 2006, Montell, 2006, Muro et al., 2006, Wells et al., 2006, Yan et al., 2006, Alvarez-Garcia and Miska, 2005, Baum et al., 2005, Csiszar et al., 2005, Juhasz and Sass, 2005, Kornbluth and White, 2005, Mazzalupo and Cooley, 2005, Perez-Garijo et al., 2005, Purves et al., 2005, Xu et al., 2005, Anonymous, 2004, Danial and Korsmeyer, 2004, Dotto and Silke, 2004, Geisbrecht and Montell, 2004, Hsu et al., 2004, Huh et al., 2004, Huh et al., 2004, Huh et al., 2004, Martin and Baehrecke, 2004, McCall, 2004, Muro et al., 2004, Ryoo et al., 2004, Shiozaki and Shi, 2004, Xu et al., 2004, Yan et al., 2004, Arama et al., 2003, Baehrecke, 2003, Baehrecke, 2003, Brachmann and Cagan, 2003, Cagan, 2003, Claveria and Torres, 2003, Ditzel et al., 2003, Lawen, 2003, Meier and Silke, 2003, Ou et al., 2003, Quinn et al., 2003, Xu et al., 2003, Zachariou et al., 2003, Adams and Cory, 2002, Ditzel and Meier, 2002, Li et al., 2002, Tenev et al., 2002, Wilson et al., 2002, Yoo et al., 2002, Yu et al., 2002, Adams and Cory, 2001, Bangs et al., 2001, Wing et al., 2001, Bangs et al., 2000, Chen and Abrams, 2000, Kumar, 2000, Petritsch et al., 2000, Rodriguez et al., 2000, Tittel and Steller, 2000, Vernooy et al., 2000, White, 2000, Abrams, 1999, White, 1999)
Dronc/Casp9
anon-EST:GreesD6
anon-EST:GressD6
anon-WO0118547.313
dronc
(Robin et al., 2019, Shinoda et al., 2019, Córdoba and Estella, 2018, Pinal et al., 2018, Kang et al., 2017, Lu et al., 2017, Martín et al., 2017, Mondal et al., 2017, Napoletano et al., 2017, Neukomm et al., 2017, Pérez et al., 2017, Recasens-Alvarez et al., 2017, Smart et al., 2017, Ding et al., 2016, Fogarty et al., 2016, Hwangbo et al., 2016, Kale et al., 2015, Means et al., 2015, Nicolson et al., 2015, Seeds et al., 2015, Wang and Baker, 2015, Zhang et al., 2015, Ballesteros-Arias et al., 2014, Fan et al., 2014, Fernández et al., 2014, Kuang et al., 2014, Liang et al., 2014, Obata et al., 2014, Obata et al., 2014, Denton et al., 2013, Dichtel-Danjoy et al., 2013, Gordon et al., 2013, Kanamori et al., 2013, Lee et al., 2013, Lee et al., 2013, Rudrapatna et al., 2013, Shklyar et al., 2013, Yacobi-Sharon et al., 2013, Florentin and Arama, 2012, Inamdar et al., 2012, Kango-Singh, 2012.10.31, Marchal et al., 2012, Shlevkov and Morata, 2012, Kanda et al., 2011, Khammari et al., 2011, Lee et al., 2011, Lee et al., 2011, Fan and Bergmann, 2010, Fan et al., 2010, Lennox and Stronach, 2010, Li et al., 2010, Lin et al., 2010, Malzer et al., 2010, Menéndez et al., 2010, Milet et al., 2010, Schoenmann et al., 2010, Truman et al., 2010, Wang et al., 2010, Amarneh et al., 2009, Chittaranjan et al., 2009, Creagh et al., 2009, Denton et al., 2009, Kondo et al., 2009, Mallik and Lakhotia, 2009, Martín et al., 2009, McNamee and Brodsky, 2009, Pérez-Garijo et al., 2009, Steele et al., 2009, Tanaka-Matakatsu et al., 2009, Xu et al., 2009, Arya and Lakhotia, 2008, Denton et al., 2008, Fan and Bergmann, 2008, Sato et al., 2008, Shapiro et al., 2008, Shlevkov and Morata, 2008, Xu and Bergmann, 2008, Akdemir et al., 2007, Berry and Baehrecke, 2007, Krieser et al., 2007, Krieser et al., 2007, Minakhina et al., 2007, Tanaka-Matakatsu et al., 2007, Thummel, 2007, Togane et al., 2007, Wells and Johnston, 2007, Yin et al., 2007, Zeitouni et al., 2007, Arama et al., 2006, Brun et al., 2006, Choi et al., 2006, Kanao and Miyachi, 2006, Kondo et al., 2006, Kuo et al., 2006, Leulier et al., 2006, Mazzalupo and Cooley, 2006, Means et al., 2006, Mendes et al., 2006, Minakhina and Steward, 2006, Moon et al., 2006, Williams et al., 2006, Xu et al., 2006, Xu et al., 2006, Akdemir et al., 2005, Kilpatrick et al., 2005, Kondo et al., 2005, Xu et al., 2005, Xu et al., 2005, Cakouros et al., 2004, Chew et al., 2004, Daish et al., 2004, Dorstyn et al., 2004, Kumar and Cakouros, 2004, Bergmann et al., 2003, Daish et al., 2003, Gorski et al., 2003, Jassim et al., 2003, Kumar et al., 2003, Li and White, 2003, Ohno et al., 2003, Cakouros et al., 2002, Dorstyn et al., 2002, Gorski and Marra, 2002, Igaki et al., 2002, Lee et al., 2002, Lee et al., 2002, Muro et al., 2002, Richardson and Kumar, 2002, Ryoo et al., 2002, Thummel and Chory, 2002, Doumanis et al., 2001, Harvey et al., 2001, Lee and Baehrecke, 2001, Lee et al., 2001, Lee et al., 2001, Simon et al., 2001, Thummel, 2001, Baehrecke, 2000, Buszczak and Cooley, 2000, Buszczak and Segraves, 2000, Kumar and Doumanis, 2000, Lee et al., 2000, Meier, 2000.4.5, Quinn et al., 2000, Vernooy et al., 2000)
Secondary FlyBase IDs
  • FBgn0025326
  • FBgn0062102
Datasets (0)
Study focus (0)
Experimental Role
Project
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Title
References (501)