Nc, Nedd2-like caspase, caspase-9
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.45
There is only one protein coding transcript and one polypeptide associated with this gene
450 (aa); 50 (kD observed)
Interacts with Diap1; residues 114-125 interact with the second BIR domain of Diap1. Can form a stable complex with Drice. Rpr can out-compete Dronc for binding Diap1, therefore removing Diap1-mediated ubiquitination.
Ubiquitinated by Diap1, leading to its subsequent degradation.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Dronc using the Feature Mapper tool.
Dronc transcripts are detected in all developmental stages on northern blots. Dronc transcripts are ubiquitously distributed in early embryos and are seen at reduced levels at later stages. High Dronc transcript levels are observed in salivary glands and midgut in late third instar larvae but not second instar larvae. Low levels of Dronc transcripts are observed throughout third instar eye discs and brain lobes. Dronc expression is also observed in egg chambers. Dronc expression is induced by ecdysone.
Processing of the full-length Dronc precursor transcript (50 kDa) differs between pupal and larval salivary gland and Malpighian tubule tissue. Only the pupal salivary gland shows a band of activated Dronc at 19 kDa, and almost no full-length protein remaining.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Dronc in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
Area matching Drosophila EST AA540020.
Nc cleaves tetrapeptide and protein substrates carboxy-terminal to glutamate as well as aspartate residues.