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Gene Dmel\Nc

General Information
Symbol	Dmel\Nc	Species	D. melanogaster
Name	Nedd2-like caspase	Annotation symbol	CG8091
Feature type	protein_coding_gene	FlyBase ID	FBgn0026404
Gene Model Status	Current	Stock availability	10 publicly available
Also Known As	Dronc
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	67D2-67D2	Sequence location	3L:9,961,543..9,964,102 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Nedd2-like caspase is referred to in FlyBase by the symbol Dmel\Nc (CG8091, FBgn0026404). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: endopeptidase activity; cysteine-type endopeptidase activity; protein homodimerization activity. There is experimental evidence for 20 unique biological process terms, many of which group under: programmed cell death; cell death; biological regulation; system development; protein maturation; gland morphogenesis; sensory organ development; neuron differentiation; gene expression; salivary gland morphogenesis. 69 alleles are reported. The phenotypes of these alleles are annotated with: organ system; organ system subdivision; external compound sense organ; peripheral nervous system; adult; cell part; embryonic/larval excretory system; imaginal precursor; adult segment; acellular anatomical structure; cell projection. It has one annotated transcript and one annotated polypeptide. Protein features are: Caspase, interleukin-1 beta convertase; DEATH-like; Peptidase C14, ICE, catalytic subunit p20; Peptidase C14, ICE, catalytic subunit p20, active site; Peptidase C14, caspase catalytic; Peptidase C14, caspase non-catalytic subunit p10; Peptidase C14, caspase precursor p45; Peptidase C14, caspase precursor p45, core. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression. Peak expression observed at stages throughout the pupal period. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval Malpighian tubules, larval trachea, adult ovary, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1641607_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Nc. Gene sequence location is 3L:9961543..9964102.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	Controlled Vocabulary Terms proteolysis References Lee et al., 2011, PLoS Genet. 7(9): e1002261
FB2012_01	Transgenic Constructs P{UAS-Nc.Y} P{UAS-Nc.S130A} Controlled Vocabulary Terms regulation of cell death Alleles Nc[S130A.Scer\UAS] Nc[Scer\UAS.cYa] References Li et al., 2011, Nat. Commun. 2: 408 Yang et al., 2010, EMBO J. 29(18): 3196--3207 Sequence features HFA11231 BKN25238
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 67D2-67D2   Limits computationally determined from genome sequence between P{PZ}fry02240 and P{lacW}l(3)L0539L0539&P{PZ}Dhh1rL562
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Nc for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Nc-RA FBtr0076347  NM_079293   2051   450
Additional Transcript Data & Comments
Reported size (kB)	2.2 (northern blot) (Dorstyn et al., 1999)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Nc-PA   FBpp0076076   51.1   450   7.07     NP_524017   AAF50180
Additional Polypeptide Data & Comments
Reported size (kDa)	450 (aa); 50 (kD observed) (Dorstyn et al., 1999)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Peptidase C14, ICE, catalytic subunit p20 (IPR001309) Peptidase C14, caspase non-catalytic subunit p10 (IPR002138) Peptidase C14, caspase precursor p45 (IPR002398) DEATH-like (IPR011029) Peptidase C14, caspase catalytic (IPR011600) Peptidase C14, caspase precursor p45, core (IPR015917) Peptidase C14, ICE, catalytic subunit p20, active site (IPR016129) Caspase, interleukin-1 beta convertase (IPR017350)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202030   AA391600   AA438366   AA439878   AA539191   AA540020   AA949214   AA949405   AA949406   AA950690   AA979226   AE014296 AAF50180   AF104357 AAD26625   AI062340   AI259409   AI294463   AI296149   AI296445   AI518496   AJ242796 CAB53565   AW944122   AX094189   AY058747 AAL13976   BG639057   BI165219   BI165499   BI166369   BI166829   BI171556   BI171692   BI172494   BI214037   BI214448   BI216367   BI234134   BI234487   BI235921   BI237237   BI243234   BI356851   BI358249   BI362378   BI372449   BI484674   BI487088   BI487161   BI572635   BI578730   BI580186   BI580207   BI641231   CA807852   CL526027   CL868556   CO181756   CO182147   CO266047   CO266314   CO278662   CO290898   CO302172   CO324957   CO328814   EC051724   EC052134   EC054138   EC055117   EC055689   EC056095   EC056407   EC056600   EC066469   EC077933   EC084483   EC194808   EC196493   EC200889   EC202731   EC210055   EC221108   EC246199   EC249791   EC261307   EV583115   X65271
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9XYF4
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References protein binding site FBsf0000159934 3L:9,961,376..9,961,435 bound_moiety=br-XP comment=Region upstream of Nc gene bound by nuclear extracts from -4hrs (prior to puparium formation). Binding complex shown to contain br protein. comment=Region or Nc promoter necessary for transcriptional activation by br protein. evidence=experimental evidence=experimental (Cakouros et al., 2002) protein binding site FBsf0000159935 3L:9,961,476..9,961,534 bound_moiety=br-XP comment=Region upstream of Nc gene bound by nuclear extracts from wandering third instar larvae. Binding complex shown to contain fkh protein. comment=Region upstream of Nc gene bound by nuclear extracts from -4hrs (prior to puparium formation). Binding complex shown to contain br protein. evidence=experimental (Cakouros et al., 2002)
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage | early   organism | ubiquitous   (Dorstyn et al., 1999) embryonic stage -- adult stage     (Dorstyn et al., 1999) third instar larval stage   eye disc   (Dorstyn et al., 1999) embryonic/larval salivary gland   (Dorstyn et al., 1999) embryonic/larval brain   (Dorstyn et al., 1999) embryonic/larval midgut   (Dorstyn et al., 1999) adult stage & oogenesis   egg chamber   (Dorstyn et al., 1999)
Additional Descriptive Data
	Nc transcripts are detected in all developmental stages on northern blots. Nc transcripts are ubiquitously distributed in early embryos and are seen at reduced levels at later stages. High Nc transcript levels are observed in salivary glands and midgut in late third instar larvae but not second instar larvae. Low levels of Nc transcripts are observed throughout third instar eye discs and brain lobes. Nc expression is also observed in egg chambers. Nc expression is induced by ecdysone. (Dorstyn et al., 1999)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference spermatogenesis & adult stage | male   spermatid cyst   • cytoplasm (Arama et al., 2003) spermatid cyst & cystic bulge   (Arama et al., 2003)
Additional Descriptive Data
	Expression of Nc protein is observed in fully elongated spermatid cysts, and is depleted from individualized spermatozoa. (Arama et al., 2003)
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0026404    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0026404 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression. Peak expression observed at stages throughout the pupal period. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0026404 expression level Developmental Stage   Expression Level embryo 00-02hr    4020 embryo 02-04hr    3914 embryo 04-06hr    1122 embryo 06-08hr    1530 embryo 08-10hr    2304 embryo 10-12hr    2669 embryo 12-14hr    2133 embryo 14-16hr    1262 embryo 16-18hr    1306 embryo 18-20hr    1118 embryo 20-22hr    1109 embryo 22-24hr    1325 larva L1    335 larva L2    530 larva L3 12hr old    622 larva L3 puffstage 1-2    1155 larva L3 puffstage 3-6    2501 larva L3 puffstage 7-9    5892 white prepupae new    8711 white prepupae 12hr    22738 white prepupae 24hr    8430 pupae 2d postWPP    5420 pupae 3d postWPP    2097 pupae 4d postWPP    12034 adult male 01day    953 adult male 05day    429 adult male 30day    358 adult female 01day    1402 adult female 05day    2272 adult female 30day    2282 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4020) embryo 02-04hr  (3914) embryo 04-06hr  (1122) embryo 06-08hr  (1530) embryo 08-10hr  (2304) embryo 10-12hr  (2669) embryo 12-14hr  (2133) embryo 14-16hr  (1262) embryo 16-18hr  (1306) embryo 18-20hr  (1118) embryo 20-22hr  (1109) embryo 22-24hr  (1325) larva L1  (335) larva L2  (530) larva L3 12hr old  (622) larva L3 puffstage 1-2  (1155) larva L3 puffstage 3-6  (2501) larva L3 puffstage 7-9  (5892) white prepupae new  (8711) white prepupae 12hr  (22738) white prepupae 24hr  (8430) pupae 2d postWPP  (5420) pupae 3d postWPP  (2097) pupae 4d postWPP  (12034) adult male 01day  (953) adult male 05day  (429) adult male 30day  (358) adult female 01day  (1402) adult female 05day  (2272) adult female 30day  (2282) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4020) embryo 02-04hr  (3914) embryo 04-06hr    1122 embryo 06-08hr  (1530) embryo 08-10hr  (2304) embryo 10-12hr  (2669) embryo 12-14hr  (2133) embryo 14-16hr    1262 embryo 16-18hr    1306 embryo 18-20hr    1118 embryo 20-22hr    1109 embryo 22-24hr    1325 larva L1    335 larva L2    530 larva L3 12hr old    622 larva L3 puffstage 1-2    1155 larva L3 puffstage 3-6  (2501) larva L3 puffstage 7-9  (5892) white prepupae new  (8711) white prepupae 12hr  (22738) white prepupae 24hr  (8430) pupae 2d postWPP  (5420) pupae 3d postWPP  (2097) pupae 4d postWPP  (12034) adult male 01day    953 adult male 05day    429 adult male 30day    358 adult female 01day  1402 adult female 05day  (2272) adult female 30day  (2282) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4020 embryo 02-04hr    3914 embryo 04-06hr    1122 embryo 06-08hr    1530 embryo 08-10hr    2304 embryo 10-12hr    2669 embryo 12-14hr    2133 embryo 14-16hr    1262 embryo 16-18hr    1306 embryo 18-20hr    1118 embryo 20-22hr    1109 embryo 22-24hr    1325 larva L1    335 larva L2    530 larva L3 12hr old    622 larva L3 puffstage 1-2    1155 larva L3 puffstage 3-6    2501 larva L3 puffstage 7-9    5892 white prepupae new    8711 white prepupae 12hr  (22738) white prepupae 24hr    8430 pupae 2d postWPP    5420 pupae 3d postWPP    2097 pupae 4d postWPP  (12034) adult male 01day    953 adult male 05day    429 adult male 30day    358 adult female 01day    1402 adult female 05day    2272 adult female 30day    2282 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4020 embryo 02-04hr    3914 embryo 04-06hr    1122 embryo 06-08hr    1530 embryo 08-10hr    2304 embryo 10-12hr    2669 embryo 12-14hr    2133 embryo 14-16hr    1262 embryo 16-18hr    1306 embryo 18-20hr    1118 embryo 20-22hr    1109 embryo 22-24hr    1325 larva L1    335 larva L2    530 larva L3 12hr old    622 larva L3 puffstage 1-2    1155 larva L3 puffstage 3-6    2501 larva L3 puffstage 7-9    5892 white prepupae new    8711 white prepupae 12hr    22738 white prepupae 24hr    8430 pupae 2d postWPP    5420 pupae 3d postWPP    2097 pupae 4d postWPP    12034 adult male 01day    953 adult male 05day    429 adult male 30day    358 adult female 01day    1402 adult female 05day    2272 adult female 30day    2282 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0026404 expression level Developmental Stage   Expression Level embryo 00-02hr    4020 embryo 02-04hr    3914 embryo 04-06hr    1122 embryo 06-08hr    1530 embryo 08-10hr    2304 embryo 10-12hr    2669 embryo 12-14hr    2133 embryo 14-16hr    1262 embryo 16-18hr    1306 embryo 18-20hr    1118 embryo 20-22hr    1109 embryo 22-24hr    1325 larva L1    335 larva L2    530 larva L3 12hr old    622 larva L3 puffstage 1-2    1155 larva L3 puffstage 3-6    2501 larva L3 puffstage 7-9    5892 white prepupae new    8711 white prepupae 12hr    22738 white prepupae 24hr    8430 pupae 2d postWPP    5420 pupae 3d postWPP    2097 pupae 4d postWPP    12034 adult male 01day    953 adult male 05day    429 adult male 30day    358 adult female 01day    1402 adult female 05day    2272 adult female 30day    2282 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4020) embryo 02-04hr  (3914) embryo 04-06hr  (1122) embryo 06-08hr  (1530) embryo 08-10hr  (2304) embryo 10-12hr  (2669) embryo 12-14hr  (2133) embryo 14-16hr  (1262) embryo 16-18hr  (1306) embryo 18-20hr  (1118) embryo 20-22hr  (1109) embryo 22-24hr  (1325) larva L1  (335) larva L2  (530) larva L3 12hr old  (622) larva L3 puffstage 1-2  (1155) larva L3 puffstage 3-6  (2501) larva L3 puffstage 7-9  (5892) white prepupae new  (8711) white prepupae 12hr  (22738) white prepupae 24hr  (8430) pupae 2d postWPP  (5420) pupae 3d postWPP  (2097) pupae 4d postWPP  (12034) adult male 01day  (953) adult male 05day  (429) adult male 30day  (358) adult female 01day  (1402) adult female 05day  (2272) adult female 30day  (2282) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4020) embryo 02-04hr  (3914) embryo 04-06hr    1122 embryo 06-08hr  1530 embryo 08-10hr  2304 embryo 10-12hr  (2669) embryo 12-14hr  2133 embryo 14-16hr    1262 embryo 16-18hr    1306 embryo 18-20hr    1118 embryo 20-22hr    1109 embryo 22-24hr    1325 larva L1    335 larva L2    530 larva L3 12hr old    622 larva L3 puffstage 1-2    1155 larva L3 puffstage 3-6  (2501) larva L3 puffstage 7-9  (5892) white prepupae new  (8711) white prepupae 12hr  (22738) white prepupae 24hr  (8430) pupae 2d postWPP  (5420) pupae 3d postWPP  2097 pupae 4d postWPP  (12034) adult male 01day    953 adult male 05day    429 adult male 30day    358 adult female 01day  1402 adult female 05day  2272 adult female 30day  2282 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4020 embryo 02-04hr    3914 embryo 04-06hr    1122 embryo 06-08hr    1530 embryo 08-10hr    2304 embryo 10-12hr    2669 embryo 12-14hr    2133 embryo 14-16hr    1262 embryo 16-18hr    1306 embryo 18-20hr    1118 embryo 20-22hr    1109 embryo 22-24hr    1325 larva L1    335 larva L2    530 larva L3 12hr old    622 larva L3 puffstage 1-2    1155 larva L3 puffstage 3-6    2501 larva L3 puffstage 7-9    5892 white prepupae new    8711 white prepupae 12hr  (22738) white prepupae 24hr    8430 pupae 2d postWPP    5420 pupae 3d postWPP    2097 pupae 4d postWPP  12034 adult male 01day    953 adult male 05day    429 adult male 30day    358 adult female 01day    1402 adult female 05day    2272 adult female 30day    2282 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4020 embryo 02-04hr    3914 embryo 04-06hr    1122 embryo 06-08hr    1530 embryo 08-10hr    2304 embryo 10-12hr    2669 embryo 12-14hr    2133 embryo 14-16hr    1262 embryo 16-18hr    1306 embryo 18-20hr    1118 embryo 20-22hr    1109 embryo 22-24hr    1325 larva L1    335 larva L2    530 larva L3 12hr old    622 larva L3 puffstage 1-2    1155 larva L3 puffstage 3-6    2501 larva L3 puffstage 7-9    5892 white prepupae new    8711 white prepupae 12hr    22738 white prepupae 24hr    8430 pupae 2d postWPP    5420 pupae 3d postWPP    2097 pupae 4d postWPP    12034 adult male 01day    953 adult male 05day    429 adult male 30day    358 adult female 01day    1402 adult female 05day    2272 adult female 30day    2282 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0026404    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0026404 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval Malpighian tubules, larval trachea, adult ovary, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0026404 expression level Tissue   Expression Level Larval Central Nervous System    134.125 Larval Midgut no informative data Larval Hindgut    93.2 Larval Malpighian Tubules    119.7 Larval Fat Body    52.8 Larval Salivary Gland no informative data Larval Trachea    158.175 Larval Carcass    138.475 Adult Head no informative data Adult Eye    29.7 Adult Brain    43.4 Adult Thoracic-Abdominal Ganglion    30.9 Adult Crop no informative data Adult Midgut    65.5 Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    34.425 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    246.2 Adult Testis    59.7 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    134.125 Larval Midgut no informative data Larval Hindgut    93.2 Larval Malpighian Tubules    119.7 Larval Fat Body    52.8 Larval Salivary Gland no informative data Larval Trachea    158.175 Larval Carcass    138.475 Adult Head no informative data Adult Eye    29.7 Adult Brain    43.4 Adult Thoracic-Abdominal Ganglion    30.9 Adult Crop no informative data Adult Midgut    65.5 Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    34.425 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    246.2 Adult Testis    59.7 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    134.125 Larval Midgut no informative data Larval Hindgut    93.2 Larval Malpighian Tubules    119.7 Larval Fat Body    52.8 Larval Salivary Gland no informative data Larval Trachea    158.175 Larval Carcass    138.475 Adult Head no informative data Adult Eye    29.7 Adult Brain    43.4 Adult Thoracic-Abdominal Ganglion    30.9 Adult Crop no informative data Adult Midgut    65.5 Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    34.425 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    246.2 Adult Testis    59.7 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    134.125 Larval Midgut no informative data Larval Hindgut    93.2 Larval Malpighian Tubules    119.7 Larval Fat Body    52.8 Larval Salivary Gland no informative data Larval Trachea    158.175 Larval Carcass    138.475 Adult Head no informative data Adult Eye    29.7 Adult Brain    43.4 Adult Thoracic-Abdominal Ganglion    30.9 Adult Crop no informative data Adult Midgut    65.5 Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    34.425 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    246.2 Adult Testis    59.7 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0026404 expression level Tissue   Expression Level Larval Central Nervous System    134.125 Larval Midgut no informative data Larval Hindgut    93.2 Larval Malpighian Tubules    119.7 Larval Fat Body    52.8 Larval Salivary Gland no informative data Larval Trachea    158.175 Larval Carcass    138.475 Adult Head no informative data Adult Eye    29.7 Adult Brain    43.4 Adult Thoracic-Abdominal Ganglion    30.9 Adult Crop no informative data Adult Midgut    65.5 Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    34.425 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    246.2 Adult Testis    59.7 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    134.125 Larval Midgut no informative data Larval Hindgut    93.2 Larval Malpighian Tubules    119.7 Larval Fat Body    52.8 Larval Salivary Gland no informative data Larval Trachea    158.175 Larval Carcass    138.475 Adult Head no informative data Adult Eye    29.7 Adult Brain    43.4 Adult Thoracic-Abdominal Ganglion    30.9 Adult Crop no informative data Adult Midgut    65.5 Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    34.425 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    246.2 Adult Testis    59.7 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    134.125 Larval Midgut no informative data Larval Hindgut    93.2 Larval Malpighian Tubules    119.7 Larval Fat Body    52.8 Larval Salivary Gland no informative data Larval Trachea    158.175 Larval Carcass    138.475 Adult Head no informative data Adult Eye    29.7 Adult Brain    43.4 Adult Thoracic-Abdominal Ganglion    30.9 Adult Crop no informative data Adult Midgut    65.5 Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    34.425 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    246.2 Adult Testis    59.7 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    134.125 Larval Midgut no informative data Larval Hindgut    93.2 Larval Malpighian Tubules    119.7 Larval Fat Body    52.8 Larval Salivary Gland no informative data Larval Trachea    158.175 Larval Carcass    138.475 Adult Head no informative data Adult Eye    29.7 Adult Brain    43.4 Adult Thoracic-Abdominal Ganglion    30.9 Adult Crop no informative data Adult Midgut    65.5 Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    34.425 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    246.2 Adult Testis    59.7 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut no informative data Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland no informative data Larval Trachea     Larval Carcass     Adult Head no informative data Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop no informative data Adult Midgut     Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary     Adult Testis     Adult Male Accessory Gland no informative data Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    no informative data   NA  Eye    29.7   NA  Brain    43.4   134.125  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    30.9   NA  Crop    no informative data   no informative data  Midgut    65.5   93.2  Hindgut    no informative data   119.7  Malpighian Tubules    no informative data   52.8  Fat Body    no informative data   no informative data  Salivary Gland    no informative data   NA  Heart    34.425   158.175  Trachea    NA   NA  VirginFemale Spermatheca    no informative data   NA  InseminatedFemale Spermatheca    no informative data   NA  Ovary    246.2   NA  Testis    59.7   NA  Male Accessory Gland    no informative data   138.475  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_23
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0026404 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8091-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal (with Df(3L)AC1) Nc11 Nc30 Nc51 lethal (with Nc11) Nc30 Nc51 lethal (with Nc30) Nc11 lethal (with Nc51) Nc11 lethal | embryonic stage, with Nca.cQa NccQa lethal | embryonic stage, with NccQa Nca.cQa lethal | embryonic stage | maternal effect | recessive NcΔA8 NcΔB3 NcΔD8 lethal | embryonic stage | recessive | rescuable maternal effect NcI24 NcI29 lethal | embryonic stage | rescuable maternal effect Nc51 lethal | first instar larval stage, with Scer\GAL4c42 NcΔN.Scer\UAS lethal | larval stage Nc11 Nc30 Nc51 lethal | larval stage, with Scer\GAL4Adh.PF NcScer\UAS.T:Avic\GFP-EGFP lethal | partially | pupal stage NcI24 NcI29 NcL32 lethal | pharate adult stage, with Scer\GAL4GMR.PF Ncpro.Scer\UAS NcΔN.Scer\UAS lethal | P-stage, with Scer\GAL4Adh.PF NcScer\UAS.T:Avic\GFP-EGFP lethal | pupal stage, with Scer\GAL4GMR.PF NcScer\UAS.T:Avic\GFP-EGFP lethal | pupal stage (with Df(3L)AC1) Nc51 lethal | pupal stage | recessive Nc51 Ncunspecified NcΔA8 NcΔB3 NcΔD8 lethal | pupal stage | temperature conditional, with Scer\GAL4GMR.PF Ncpro.Scer\UAS NcΔN.Scer\UAS lethal | recessive NcI24 NcKG02994 semi-lethal, with Scer\GAL4c42 Ncpro.Scer\UAS viable NcEY08574 NcEY12339 viable, with Scer\GAL4pnr-MD237 NcGD12376 Sterility Allele female sterile NcI24 NcI29 NcL32 fertile NcEY08574 NcEY12339 male sterile NcI24 NcI29 NcL32 Other Phenotypes Allele cell death defective NcI24 NcI29 cell death defective, with Scer\GAL4Crz.504 NcScer\UAS.T:Avic\GFP-EGFP cell death defective (with Nc51) NcI24 NcI29 cell death defective (with NcI24) Nc51 cell death defective (with NcI29) Nc51 cell death defective | somatic clone Nc51 cell shape defective, with Scer\GAL4Act5C.PI NcdsRNA.cOa.Scer\UAS chemical resistant | recessive | wandering third instar larval stage Nc51 decreased cell death NcdsRNA.cKa NcΔA8 NcΔB3 NcΔD8 decreased cell death, with Nca.cQa NccQa decreased cell death, with NccQa Nca.cQa decreased cell death | embryonic stage 12 | rescuable maternal effect Nc51 decreased cell death | embryonic stage 15 | rescuable maternal effect Nc51 decreased cell death | larval stage Nc11 Nc30 decreased cell death | pupal stage, with Scer\GAL4fkh.PH Ncpro.C-A.Scer\UAS decreased cell death | pupal stage, with Scer\GAL4hs.PB Ncpro.C-A.Scer\UAS decreased cell death | recessive | wandering third instar larval stage Nc51 decreased cell death | rescuable maternal effect NcI24 NcI29 decreased cell number, with Scer\GAL4c42 Ncpro.Scer\UAS developmental rate defective NcKG02994 developmental rate defective, with Scer\GAL4elav-C155 NcScer\UAS.cYa developmental rate defective | larval stage Nc11 Nc30 Nc51 eye color defective NcGMR.PH eye color defective, with Scer\GAL4GMR.PF Ncpro.Scer\UAS NcΔN.Scer\UAS increased cell death NcMPD.MtnA NcMtnA.PQ increased cell death, with Scer\GAL4GMR.PF NcS130A.Scer\UAS NcScer\UAS.cYa NcScer\UAS.T:Avic\GFP-EGFP increased cell death, with Scer\GAL4hs.PB NcScer\UAS.T:Avic\GFP-EGFP neuroanatomy defective Nc11 Nc51 NcΔA8 neuroanatomy defective, with Scer\GAL4477 NcC318G.Scer\UAS.T:Avic\GFP-EGFP neuroanatomy defective, with Scer\GAL4ppk.1.9 NcGD12376 NcΔN.C-A.Scer\UAS short lived, with Scer\GAL4elav-C155 NcScer\UAS.T:Avic\GFP-EGFP short lived | recessive Ncunspecified size defective | larval stage Nc11 Nc30 Nc51 visible NcGMR.PH NcGMR.PY visible, with Scer\GAL4GMR.PF Ncpro.Scer\UAS NcScer\UAS.T:Avic\GFP-EGFP NcΔN.Scer\UAS visible, with Scer\GAL4sca-P309 NcC318G.Scer\UAS NcdsRNA.Scer\UAS visible (with NcI24) NcI29 visible (with NcI29) NcI24 visible | male (with NcI24) NcI29 visible | male (with NcI29) NcI24 wild-type NcC318G.MtnA Phenotype manifest in Allele adult head, with Scer\GAL4GMR.PF Ncpro.Scer\UAS adult head | temperature conditional, with Scer\GAL4GMR.PF NcΔN.Scer\UAS Ncpro.Scer\UAS Bolwig organ | embryonic stage 15 | rescuable maternal effect Nc51 cystic bulge NcI24 NcI29 NcL32 dendrite Nc11 NcI24 Nc51 NcΔA8 dendrite, with Scer\GAL4477 NcC318G.Scer\UAS.T:Avic\GFP-EGFP dendrite, with Scer\GAL4ppk.1.9 NcΔN.C-A.Scer\UAS NcGD12376 dorsal multidendritic neuron ddaC NcΔA8 dorsal multidendritic neuron ddaC, with Scer\GAL4477 NcC318G.Scer\UAS.T:Avic\GFP-EGFP dorsal multidendritic neuron ddaC, with Scer\GAL4ppk.1.9 NcΔN.C-A.Scer\UAS NcGD12376 dorsal ridge primordium | rescuable maternal effect Nc51 embryonic/larval brain | wandering third instar larval stage Nc51 embryonic/larval digestive system (with Df(3L)AC1) Nc2 embryonic/larval digestive system (with Nc2) Nc51 embryonic/larval digestive system (with Nc51) Nc2 embryonic/larval fat body | wandering third instar larval stage, with Scer\GAL4Adh.PF NcScer\UAS.T:Avic\GFP-EGFP embryonic/larval hemocyte | supernumerary Nc51 embryonic/larval Malpighian tubule, with Scer\GAL4c42 Ncpro.Scer\UAS embryonic/larval midgut | late third instar larval stage Nc51 embryonic/larval salivary gland | P-stage, with Scer\GAL4fkh.PH Ncpro.C-A.Scer\UAS embryonic/larval salivary gland | P-stage, with Scer\GAL4hs.PB Ncpro.C-A.Scer\UAS embryonic head | rescuable maternal effect NcI24 NcI29 eo neuron | supernumerary, with Scer\GAL4sca-P309 NcC318G.Scer\UAS eye NcGMR.PH Ncunspecified NcGMR.PY eye, with Scer\GAL4GMR.PF NcΔN.Scer\UAS NcScer\UAS.T:Avic\GFP-EGFP Ncpro.Scer\UAS NcScer\UAS.cYa NcS130A.Scer\UAS eye | somatic clone Nc51 eye | temperature conditional, with Scer\GAL4GMR.PF NcΔN.Scer\UAS Ncpro.Scer\UAS eye disc, with Scer\GAL4GMR.PF NcΔN.Scer\UAS eye disc | posterior, with Scer\GAL4GMR.PF NcScer\UAS.T:Avic\GFP-EGFP eye disc | P-stage, with Scer\GAL4GMR.PF Ncpro.Scer\UAS eye disc | somatic clone NcI24 eye photoreceptor cell NcGMR.PH eye photoreceptor cell, with Scer\GAL4GMR.PF Ncpro.Scer\UAS imaginal disc | wandering third instar larval stage Nc51 imaginal disc epithelial cell | somatic clone Nc51 inter-ommatidial precursor cell | pharate adult stage P9 | supernumerary, with Scer\GAL4GMR.PF NcdsRNA.Scer\UAS.cLa macrochaeta | supernumerary, with Scer\GAL4sca-P309 NcC318G.Scer\UAS NcdsRNA.Scer\UAS male genitalia (with NcI24) NcI29 male genitalia (with NcI29) NcI24 melanotic mass (with Df(3L)AC1) Nc2 melanotic mass (with Nc2) Nc51 melanotic mass (with Nc51) Nc2 midline glial cell | maternal effect | supernumerary NcI29 neuroblast & larval abdominal segment 3 | late third instar larval stage Nc11 Nc30 neuroblast & larval abdominal segment 4 | late third instar larval stage Nc11 Nc30 neuroblast & larval abdominal segment 5 | late third instar larval stage Nc11 Nc30 neuroblast & larval abdominal segment 6 | late third instar larval stage Nc11 Nc30 neuroblast & larval abdominal segment 7 | late third instar larval stage Nc11 Nc30 neuron Nc11 NcI24 NcI29 Nc51 neuron, with Scer\GAL4Crz.504 NcScer\UAS.T:Avic\GFP-EGFP neuron (with Nc51) NcI24 NcI29 neuron (with NcI24) Nc51 neuron (with NcI29) Nc51 neuron & ventral nerve cord | ectopic (with Nc51) NcI24 neuron & ventral nerve cord | ectopic (with NcI24) Nc51 ommatidial precursor cluster | somatic clone Nc51 ommatidium, with Scer\GAL4GMR.PF NcΔN.Scer\UAS NcScer\UAS.T:Avic\GFP-EGFP Ncpro.Scer\UAS ommatidium | cell autonomous | somatic clone NcI29 ommatidium | somatic clone Nc51 pigment cell NcGMR.PH pigment cell, with Scer\GAL4GMR.PF NcΔN.Scer\UAS NcScer\UAS.T:Avic\GFP-EGFP Ncpro.Scer\UAS postalar bristle | supernumerary NcKG02994 Nc51 presumptive embryonic/larval central nervous system | maternal effect NcI29 retina NcGMR.PH retinal pigment cell, with Scer\GAL4GMR.PF NcScer\UAS.cYa salivary gland | pupal stage, with Scer\GAL434B NcdsRNA.Scer\UAS.cLa scolopidial neuron | maternal effect | supernumerary NcI29 sensory mother cell | supernumerary, with Scer\GAL4sca-P309 NcC318G.Scer\UAS spermatid NcDn.βTub85D NcI24 NcI29 NcL32 thecogen cell | supernumerary, with Scer\GAL4sca-P309 NcC318G.Scer\UAS ventral nerve cord | late embryonic stage | rescuable maternal effect Nc51 ventral nerve cord primordium | embryonic stage 15 | rescuable maternal effect Nc51 ventral trunk epidermis primordium | embryonic stage 12 | rescuable maternal effect Nc51 waste bag NcDn.βTub85D NcI24 NcI29 NcL32 wing NcI24 NcI29 Ncunspecified NcΔA8 NcΔB3 NcΔD8 wing, with Scer\GAL4elav-C155 NcScer\UAS.cYa NcS130A.Scer\UAS wing (with NcI24) NcI29 wing (with NcI29) NcI24 wing | adult stage A3 | somatic clone Nc51 wing | somatic clone Nc51
Classical Alleles ( 22 )
For All Classical Alleles Show
Allele of Nc Class Mutagen Stocks Known lesion NcKG02994 hypomorphic allele - genetic evidence 2 Yes Nc51 amorphic allele - genetic evidence Delta2-3 1 Yes Ncc01030 1 -- NcEY08574 P-element activity 1 Yes NcEY12339 P-element activity 1 -- NcI24 amorphic allele - genetic evidence, loss of function allele ethyl methanesulfonate 0 Yes NcI29 amorphic allele - genetic evidence, loss of function allele ethyl methanesulfonate 0 Yes Nc11 P-element activity 0 Yes Nc1 ethyl methanesulfonate 0 Yes Nc2 ethyl methanesulfonate 0 Yes Nc30 P-element activity 0 Yes NcF118E.GMR 0 -- NcL32 loss of function allele, hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes Ncrev78 Delta2-3 0 Yes Ncrev79 Delta2-3 0 Yes Ncunspecified 0 -- NcZ P-element activity 0 Yes NcΔA1 P-element activity 0 Yes NcΔA8 P-element activity 0 Yes NcΔB3 P-element activity 0 Yes NcΔD8 P-element activity 0 Yes NcΔE10 P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 47 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Nc Class Mutagen Stocks Known lesion NcGD12376 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes NcHMS00758 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes NcKK104278 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Nc+t.drf in vitro construct - genomic fragment 0 Yes Nca.cIa in vitro construct - RNAi in vitro construct 0 Yes Nca.cQa in vitro construct - RNAi 0 Yes NcC318A.MtnA.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - site directed mutagenesis 0 Yes NcC318A.MtnA.T:Zzzz\FLAG in vitro construct - coding region fusion in vitro construct - regulatory fusion 0 Yes NcC318G.MtnA in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes NcC318G.Scer\UAS.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes NcC318G.Scer\UAS in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes NcC318S.cYa.GMR 0 Yes NcC318S.GMR in vitro construct - regulatory fusion 0 Yes NcC318S.Scer\UAS in vitro construct - regulatory fusion 0 Yes NcCARD.Scer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes NcCARD.Scer\UAS in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes NccIa in vitro construct - RNAi in vitro construct 0 Yes NccQa in vitro construct - RNAi 0 Yes NcDn.βTub85D in vitro construct - regulatory fusion 0 Yes NcdsRNA.1-765 in vitro construct - RNAi 0 Yes NcdsRNA.16-1160 in vitro construct - RNAi 0 Yes NcdsRNA.781-1047 in vitro construct - RNAi 0 Yes NcdsRNA.cDa in vitro construct - RNAi 0 Yes NcdsRNA.cKa in vitro construct - RNAi 0 Yes NcdsRNA.cMa in vitro construct - RNAi 0 Yes NcdsRNA.cOa.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes NcdsRNA.Scer\UAS.cLa in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes NcdsRNA.Scer\UAS in vitro construct - coding region fusion in vitro construct - RNAi 0 Yes NcE352A.GMR in vitro construct - regulatory fusion 0 Yes NcGMR.PH in vitro construct - regulatory fusion 0 Yes NcGMR.PY in vitro construct - regulatory fusion 0 Yes NcMPD.MtnA in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes NcMtnA.PQ in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes NcMtnA.T:Ivir\HA1,T:Zzzz\His6 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes NcMtnA.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes NcNIG.8091-R1 0 Yes Ncpro.C-A.Scer\UAS in vitro construct - regulatory fusion in vitro construct - deletion in vitro construct - amino acid replacement 0 Yes Ncpro.Scer\UAS in vitro construct - regulatory fusion 0 Yes NcS130A.Scer\UAS in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes NcScer\UAS.cIa in vitro construct - regulatory fusion 0 Yes NcScer\UAS.cYa in vitro construct - regulatory fusion 0 Yes NcScer\UAS.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes NcScer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes NctDa in vitro construct 0 Yes NcΔN.C-A.Scer\UAS in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes NcΔN.MtnA in vitro construct - regulatory fusion 0 Yes NcΔN.Scer\UAS in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes
Aneuploid Aberrations
Partially disrupted in	Df(3L)Nc11 (Waldhuber et al., 2005) Df(3L)NcZ (Daish et al., 2004) Df(3L)NcΔE10 (Kondo et al., 2006)
Disrupted in	Df(3L)AC1 (Tenev et al., 2002, Xu et al., 2005) Df(3L)vncM2 (Wang et al., 2010) Df(3L)vncMK (Wang et al., 2010)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD12376} NA P{KK104278} NA P{TRiP.HMS00758} NA P{UAS-dronc.C318G} NA P{UAS-dronc-CARD} NA P{UAS-Nc.C318S} NA P{UAS-Nc.dsRNA} NA P{UAS-Nc.EGFP.C318G} NA P{UAS-Nc.EGFP} NA P{UAS-Nc.S130A} NA P{UAS-Nc.Y} NA P{UAS-pro-dronc.C->A} NA P{UAS-pro-dronc} NA P{UAS-ΔNdronc.C->A} NA P{UAS-ΔNdronc} NA reporter construct P{Nc-lacZ.0.54} No P{Nc-lacZ.1.1} No P{Nc-LacZ.1.33kb} No P{Nc-LacZ.1.64kb} No P{Nc-lacZ.2.3} No P{Nc-lacZ.2.8} No P{Nc-LacZ.2.8kb} No P{Nc-LacZ.2.8kbEcRBE} No characterization construct P{CG6685+tDa} NA P{drf} NA P{GMR-Nc.C318S.cYa} NA P{GMR-Nc.C318S} NA P{GMR-Nc.E352A} NA P{GMR-Nc.H} NA P{GMR-Nc.WT} NA P{NIG.8091-R1} NA P{Tub-Dn-DRONC} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}NcEY08574 NA P{EPgy2}NcEY12339 NA miscellaneous insertions P{SUPor-P}NcKG02994 NA PBac{PB}Ncc01030 NA
Gene Ontology: Function, Process & Cellular Component ( 30 unique terms )
Terms Based on Experimental Evidence ( 25 terms )
Molecular Function
CV term Evidence References
cysteine-type endopeptidase activity inferred from direct assay (Meier et al., 2000, Kanuka et al., 2005) inferred from direct assay AND inferred from sequence or structural similarity with worm ced-3 (Dorstyn et al., 1999) endopeptidase activity inferred from direct assay (Yan et al., 2006) protein homodimerization activity inferred from direct assay (Yan et al., 2006)
Biological Process
CV term Evidence References
activation of caspase activity inferred from mutant phenotype (Akdemir et al., 2007) apoptotic process inferred from expression pattern AND inferred from mutant phenotype (Dorstyn et al., 1999) inferred from genetic interaction with th (Meier et al., 2000) inferred from mutant phenotype (Chew et al., 2004, Xu et al., 2005, Meier et al., 2000) inferred from physical interaction with th (Meier et al., 2000) autophagic cell death inferred from expression pattern (Gorski et al., 2003) central nervous system development inferred from mutant phenotype (Chew et al., 2004) compound eye development inferred from mutant phenotype (Chew et al., 2004) dendrite morphogenesis inferred from mutant phenotype (Williams et al., 2006) determination of adult lifespan inferred from mutant phenotype (Bauer et al., 2005) developmental programmed cell death inferred from mutant phenotype (Kondo et al., 2006) head involution inferred from mutant phenotype (Chew et al., 2004) hemocyte development inferred from mutant phenotype (Chew et al., 2004) neuron remodeling inferred from mutant phenotype (Schoenmann et al., 2010) positive regulation of compound eye retinal cell programmed cell death inferred from mutant phenotype (Leulier et al., 2006) programmed cell death inferred from direct assay (Lee et al., 2011) protein autoprocessing inferred from direct assay (Yan et al., 2006) regulation of cell death inferred from mutant phenotype (Yang et al., 2010) salivary gland cell autophagic cell death inferred from expression pattern (Gorski et al., 2003) salivary gland histolysis inferred from mutant phenotype (Leulier et al., 2006) sensory organ development inferred from mutant phenotype (Kanuka et al., 2005) sperm individualization inferred from mutant phenotype (Huh et al., 2004, Arama et al., 2006) zymogen activation inferred from direct assay (Yan et al., 2006) inferred from mutant phenotype (Yan et al., 2006)
Cellular Component
CV term Evidence References
cytoplasm inferred from direct assay (Dorstyn et al., 1999) NOT mitochondrion inferred from direct assay (Dorstyn et al., 1999)
Terms Based on Predictions or Assertions ( 7 terms )
Molecular Function
CV term Evidence References
cysteine-type endopeptidase activity non-traceable author statement (Kumar, 1998.11.4) traceable author statement (Kumar and Doumanis, 2000, Richardson and Kumar, 2002, Brachmann and Cagan, 2003, Tittel and Steller, 2000, Abrams, 1999)
Biological Process
CV term Evidence References
apoptotic process non-traceable author statement (Lawen, 2003) traceable author statement (Kumar and Doumanis, 2000, Richardson and Kumar, 2002, Bergmann et al., 2003) embryonic development via the syncytial blastoderm non-traceable author statement (Kumar and Doumanis, 2000) traceable author statement (Richardson and Kumar, 2002) induction of programmed cell death by hormones traceable author statement (Buszczak and Segraves, 2000) metamorphosis traceable author statement (Kumar and Doumanis, 2000) proteolysis inferred from electronic annotation with InterPro:IPR001309, InterPro:IPR002138, InterPro:IPR002398, InterPro:IPR011600, InterPro:IPR016129 (FlyBase Curators et al., 2004-) regulation of retinal cell programmed cell death non-traceable author statement (Brachmann and Cagan, 2003)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Nc allele Gene References Nca.cIa rpr (Igaki et al., 2002) th (Igaki et al., 2002) NcC318G.Scer\UAS egr (Igaki et al., 2002) rpr (Igaki et al., 2002) NcC318S.GMR BacA\p35 (Yu et al., 2002) grim (Hawkins et al., 2000, Wing et al., 2001) rpr (Hawkins et al., 2000, Wing et al., 2001) W (Hawkins et al., 2000) NcC318S.Scer\UAS BacA\p35 (Huh et al., 2004) NcCARD.Scer\UAS egr (Moreno et al., 2002) Rac1 (Geisbrecht and Montell, 2004) rpr (Meier et al., 2000) NccIa rpr (Igaki et al., 2002) th (Igaki et al., 2002) NcdsRNA.16-1160 th (Muro et al., 2002) NcGMR.PH mir-14 (Xu et al., 2003) th (Hawkins et al., 2000) NcMPD.MtnA Iap2 (Quinn et al., 2000) th (Quinn et al., 2000) Ncpro.C-A.Scer\UAS rpr (Meier et al., 2000) Ncpro.Scer\UAS eff (Ryoo et al., 2002) th (Meier et al., 2000, Wilson et al., 2002) NcScer\UAS.T:Avic\GFP-EGFP Ark (Quinn et al., 2000) BacA\p35 (Huh et al., 2004) Iap2 (Quinn et al., 2000) th (Quinn et al., 2000) NcΔN.C-A.Scer\UAS Rac1 (Geisbrecht and Montell, 2004) unspecified Ark (Chew et al., 2004) grim (Yan et al., 2006) rpr (Yan et al., 2006, Quinn et al., 2000, Xu et al., 2005) sgg (Kanuka et al., 2005) th (Xu et al., 2005) W (Yan et al., 2006, Quinn et al., 2000, Xu et al., 2005) wg (Wells et al., 2006, Kanuka et al., 2005)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 64560 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0026404 DroID - A comprehensive database of gene and protein interactions. • FBgn0026404 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39173
Orthologs
Genome-wide drosophilid orthologs	Dana\GF10584 Dere\GG15422 Dgri\GH16053 Dmoj\GI12317 Dper\GL12563 Dpse\GA20817 Dsec\GM25197 Dsim\GD14228 Dvir\GJ13253 Dwil\GK16787 Dyak\GE21731
Curated drosophilid orthologs	Dpse\GA20817
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL011562-PA Aedes aegypti (mosquito) AGAP004754-PA Anopheles gambiae (mosquito) BGIBMGA002841-PA Bombyx mori (silk worm) ENSCINP00000007986 Ciona intestinalis (sea squirt) CPIJ002923 Culex pipens (mosquito) ENSCSAVP00000009349 Ciona savignyi (sedentary tunicate) 209613 Capitella spl (polychaete worm) ISCW014750-PA Ixodes scapularis (deer tick) XP_001602058.1 Nasonia vitripennis (wasp) PHUM009584-PA Pediculus humanus (human body louse) XP_001813274.1 Tribolium castaneum (red flour beetle) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV21460 NV15018 LH12760 FBgn0238977 FBgn0218787 FBgn0200479 FBgn0185914 FBgn0180057 JGI_V11_216854 FBgn0080807 FBgn0150169 FBgn0135074 FBgn0123524 FBgn0107673 FBgn0087625 CPIJ002923 BGIBMGA002841 ACYPI43249 ACYPI25243 GB18722 CASPL2 PB20887 PHUM428060 GLEAN_12579 GLEAN_12580 GLEAN_12581
Stocks & Reagents
Stocks Listed in FlyBase ( 10 )
Bloomington	17475 y1 w67c23; P{EPgy2}NcEY08574 20736 y1 w67c23; P{EPgy2}NcEY12339 23284 y1 w*; Nc51/TM3, Sb1 32963 y1 sc* v1; P{TRiP.HMS00758}attP2 13338 y1; P{SUPor-P}NcKG02994 ry506/TM3, Sb1 Ser1
Harvard	- PBac{PB}Ncc01030
Kyoto	111539 yd2 w1118 P{ey-FLP.N}2 P{GMR-lacZ.C(38.1)}TPN1; P{SUPor-P}NcKG02994 P{neoFRT}80B/TM6B, P{Car20y}TPN1, Tb1
VDRC	v100424 P{KK104278}VIE-260B v23033 w1118; P{GD12376}v23033 v23035 w1118; P{GD12376}v23035
Genomic Clones ( 1 )
	BACR16K12 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 77 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LP09975
Other clones	DPiM_LP09975
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH01511 LD03633 LD10648 LD12627 LD14558 LD18847 LD19343 LD28024 LD28291 LD28292 LD30667 LD33560 LD38033 LD42745 LP02817 LP07841 LP10341 RE05059 RE05417 RE06475 RE07052 RE13362 RE13521 RE15006 RE19730 RE20261 RE23484 RE29779 RE30191 RE31878 RE33427 RE40812 RE43105 RE44961 RE46921 RE59413 RE67815 RE70594 RE70676 RE72638 RE74334 RE74356 RH08224 SD24451
Other clones	18103 21388 35390 59194 66937 107554 160564 160638 160654 533941 CK01.21D.F10 CK01.97C.E3 Dmel_dig_013345_0708_0759 EC14933 EC22167 EC051724 EC052134 EC054138 EC055117 EC055689 EC056095 EC056407 EC056600 EK075518 EK130862 EK144801 EK146015 EK183319 EK195236 EK291448 ESG019d.E21_H12
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0026404 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39173
Antibody Information
	polyclonal (Koto et al., 2009, Settles and Friesen, 2008, Yang et al., 2010) polyclonal antibody (Arama et al., 2003)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Nc CG8091 (Zhang, 1999.11)
Source for database merge of	Source for merge of: Nc anon-EST:GressD6 (FlyBase, 1996-) Source for merge of: Nc anon-WO0118547.313 (FlyBase, 1996-)
Additional comments	Source for merge of Nc anon-WO0118547.313 was sequence comparison (date:051113). (FlyBase, 1996-) Source for merge of Nc anon-EST:GressD6 was sequence comparison (date:030707). (FlyBase, 1996-)
Other Comments
	Nc has a role in the coordination of tissue growth; when growth rate is reduced in a specific territory in the developing wing disc, Nc reduces cell proliferation rates in adjacent cell populations. (Mesquita et al., 2010) Nc activity has a negative effect on border follicle cell migration. (Geisbrecht and Montell, 2004) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) Area matching Drosophila EST AA540020. (Davies, 2001.3.15) Nc cleaves tetrapeptide and protein substrates carboxy-terminal to glutamate as well as aspartate residues. (Hawkins et al., 2000) th interacts with the pro-domain of Nc and appears to be a critical regulator of activation of Nc in vivo. Nc appears to act in the rpr and W pathway. (Meier et al., 2000) Loss of Nc function in early embryos results in a dramatic decrease in cell death in the embryos. (Quinn et al., 2000)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079293 RefSeq (Proteins) • NP_524017 DDBJ / EMBL / GenBank • AA438366 AA540020 AA949406 AA950690 AAD26625 AAF50180 AAL13976 AF104357 AI296149 AJ242796 AW944122 AX094189 AY058747 CAB53565 CL526027 CL868556 X65271 Entrez Gene - A searchable database of RefSeq genes. • 39173 UniProtKB/TrEMBL • Q9XYF4
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Peptidase C14, ICE, catalytic subunit p20 (IPR001309) Peptidase C14, caspase non-catalytic subunit p10 (IPR002138) Peptidase C14, caspase precursor p45 (IPR002398) DEATH-like (IPR011029) Peptidase C14, caspase catalytic (IPR011600) Peptidase C14, caspase precursor p45, core (IPR015917) Peptidase C14, ICE, catalytic subunit p20, active site (IPR016129) Caspase, interleukin-1 beta convertase (IPR017350)
Linkouts
	BioGRID - A database of protein and genetic interactions • 64560 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0026404 DroID - A comprehensive database of gene and protein interactions. • FBgn0026404 DRSC - Results from RNAi screens. • FBgn0026404 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0026404 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8091-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0026404 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39173 InParanoid A subset of ortholog calls from InParanoid. • AAEL011562-PA Aedes aegypti (mosquito) AGAP004754-PA Anopheles gambiae (mosquito) BGIBMGA002841-PA Bombyx mori (silk worm) ENSCINP00000007986 Ciona intestinalis (sea squirt) CPIJ002923 Culex pipens (mosquito) ENSCSAVP00000009349 Ciona savignyi (sedentary tunicate) 209613 Capitella spl (polychaete worm) ISCW014750-PA Ixodes scapularis (deer tick) XP_001602058.1 Nasonia vitripennis (wasp) PHUM009584-PA Pediculus humanus (human body louse) XP_001813274.1 Tribolium castaneum (red flour beetle) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /dbzhnsky/dronc1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39173 modMine - Data generated by the modENCODE project. • FBgn0026404 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV21460 NV15018 LH12760 FBgn0238977 FBgn0218787 FBgn0200479 FBgn0185914 FBgn0180057 JGI_V11_216854 FBgn0080807 FBgn0150169 FBgn0135074 FBgn0123524 FBgn0107673 FBgn0087625 CPIJ002923 BGIBMGA002841 ACYPI43249 ACYPI25243 GB18722 CASPL2 PB20887 PHUM428060 GLEAN_12579 GLEAN_12580 GLEAN_12581 REDfly - A database of transcriptional regulatory elements. • FBgn0026404
Synonyms & Secondary IDs ( 16 )
Reported As
Symbol Synonym	anon-EST:GreesD6   anon-EST:GressD6   anon-WO0118547.313   caspase-9 (Mendes et al., 2006) CG8090 (Yi et al., 2007) CG8091 (Lee et al., 2003, Begun et al., 2007, Liu et al., 2009, Keleman et al., 2009.8.5, Ni et al., 2010.12.1, Kanao and Miyachi, 2006) Dronc (Baum et al., 2007, Cakouros et al., 2008, Alvarez-Garcia and Miska, 2005, Perez-Garijo et al., 2005, Xu et al., 2005, Dotto and Silke, 2004, Meier and Silke, 2003, Adams and Cory, 2001, Shiozaki and Shi, 2004, Anonymous, 2004, Huh et al., 2004, Abrams, 1999, Purves et al., 2005, Mazzalupo and Cooley, 2005, Csiszar et al., 2005, Baum et al., 2005, Xu et al., 2004, McCall, 2004, Geisbrecht and Montell, 2004, Zachariou et al., 2003, Martin and Baehrecke, 2004, Arama et al., 2003, Huh et al., 2004, Danial and Korsmeyer, 2004, Huh et al., 2004, Lawen, 2003, Baehrecke, 2003, Adams and Cory, 2002, Kumar, 2000, Cagan, 2003, Quinn et al., 2003, Ou et al., 2003, Ditzel et al., 2003, Xu et al., 2003, Yoo et al., 2002, Tittel and Steller, 2000, Claveria and Torres, 2003, Ditzel and Meier, 2002, Wilson et al., 2002, Brachmann and Cagan, 2003, Tenev et al., 2002, Yu et al., 2002, Wing et al., 2001, Bangs et al., 2001, Bangs et al., 2000, Vernooy et al., 2000, White, 2000, Rodriguez et al., 2000, Petritsch et al., 2000, Chen and Abrams, 2000, White, 1999, Mendes et al., 2006, Shin and Yoo, 2007, Kim and Yoo, 2007, Fan and Bergmann, 2007, McCall et al., 2007, Chew et al., 2007, Caldwell and Eberl, 2007, Bergman, 2006.7.7, Muro et al., 2006, Wells et al., 2006, Ryoo et al., 2004, Bergmann, 2006, Huh et al., 2007, Kuranaga and Miura, 2007, Hsu et al., 2004, Baehrecke, 2006, Montell, 2006, Li et al., 2002, Fan and Bergmann, 2008, Li and Cadigan, 2008, Domingues and Ryoo, 2008, Pret et al., 2008, Tsujimura et al., 2008, Yan et al., 2006, Baehrecke, 2003, Kornbluth and White, 2005, Mesquita et al., 2010, Li et al., 2011, Wu et al., 2007, Link et al., 2007, Yi et al., 2007, Lee et al., 2008, Takemoto et al., 2007, Muro et al., 2004, Chandraratna et al., 2007, Caldwell et al., 2008, Primrose et al., 2007, Copeland et al., 2007, Herman-Bachinsky et al., 2007, Tenev et al., 2007, Ribaya et al., 2009, Liu et al., 2009, Glavic et al., 2009, Kuo et al., 2006, Koto et al., 2009, Paquette et al., 2010, Yuan et al., 2011, Tao and Rolls, 2011, Suissa et al., 2011, Juhasz and Sass, 2005, Yan et al., 2004, Yang et al., 2010) DRONC (Bedoukian et al., 2009, Kanuka et al., 2005, Cakouros et al., 2004, Igaki and Miura, 2004, Morey et al., 2003, Varfolomeev and Ashkenazi, 2004, Jabbour et al., 2002, Ilangovan et al., 2003, Moreno and Basler, 2003, Moreno et al., 2002, Kanda et al., 2002, Martin, 2002, Igaki et al., 2002, Petritsch et al., 2000, Yu et al., 2001, Matova and Cooley, 2001, Meier et al., 2000, Hu and Yang, 2000, Hawkins et al., 2000, Jones et al., 2000, Meier et al., 2000, Kanuka et al., 1999, Igaki et al., 2000, Kumar, 1998.11.4, Wang et al., 1999, Quinn et al., 1999, Dorstyn et al., 1999, Waldhuber et al., 2005, Muro, 2005, Bauer et al., 2005, Adrain, 2006, Dorstyn et al., 2004, Oshima et al., 2006, Oshima, 2006, Kuranaga et al., 2006, Renault et al., 2004, Waldhuber et al., 2005, Luo et al., 2007, Challa et al., 2007, Morey et al., 2003, Chandraratna et al., 2007, Dorstyn and Kumar, 2008, Snipas et al., 2008, Ditzel et al., 2008, Ertürk-Hasdemir et al., 2009, Williams et al., 2006, Shukla and Tapadia, 2011, Lannan et al., 2007, Settles and Friesen, 2008) dronc (Arama et al., 2006, Kilpatrick et al., 2005, Li and White, 2003, Kondo et al., 2005, Xu et al., 2005, Akdemir et al., 2005, Kumar and Cakouros, 2004, Cakouros et al., 2004, Bergmann et al., 2003, Jassim et al., 2003, Dorstyn et al., 2002, Cakouros et al., 2002, Kumar et al., 2003, Muro et al., 2002, Ryoo et al., 2002, Igaki et al., 2002, Thummel and Chory, 2002, Lee et al., 2002, Ohno et al., 2003, Lee et al., 2002, Richardson and Kumar, 2002, Gorski and Marra, 2002, Simon et al., 2001, Lee et al., 2001, Lee et al., 2001, Thummel, 2001, Harvey et al., 2001, Lee and Baehrecke, 2001, Kumar and Doumanis, 2000, Buszczak and Segraves, 2000, Quinn et al., 2000, Buszczak and Cooley, 2000, Baehrecke, 2000, Vernooy et al., 2000, Lee et al., 2000, Meier, 2000.4.5, Gorski et al., 2003, Xu et al., 2006, Chew et al., 2004, Minakhina and Steward, 2006, Wells and Johnston, 2007, Tanaka-Matakatsu et al., 2007, Krieser et al., 2007, Choi et al., 2006, Xu et al., 2005, Dorstyn et al., 2004, Doumanis et al., 2001, Togane et al., 2007, Lennox and Stronach, 2010, Daish et al., 2003, Berry and Baehrecke, 2007, Denton et al., 2008, Xu and Bergmann, 2008, Shlevkov and Morata, 2008, Williams et al., 2006, Akdemir et al., 2007, Krieser et al., 2007, Thummel, 2007, Wang et al., 2010, Kondo et al., 2006, Moon et al., 2006, Zeitouni et al., 2007, Mendes et al., 2006, Minakhina et al., 2007, Daish et al., 2004, Fan and Bergmann, 2008, Yin et al., 2007, Kuo et al., 2006, Sato et al., 2008, Means et al., 2006, Leulier et al., 2006, Shapiro et al., 2008, Xu et al., 2006, Tanaka-Matakatsu et al., 2009, Chittaranjan et al., 2009, Pérez-Garijo et al., 2009, Amarneh et al., 2009, Creagh et al., 2009, Brun et al., 2006, Steele et al., 2009, Martín et al., 2009, Kondo et al., 2009, Arya and Lakhotia, 2008, Denton et al., 2009, Mallik and Lakhotia, 2009, Lin et al., 2010, Truman et al., 2010, Li et al., 2010, Fan and Bergmann, 2010, Fan et al., 2010, Schoenmann et al., 2010, Menéndez et al., 2010, Malzer et al., 2010, Lee et al., 2011, Kanao and Miyachi, 2006) Dronc/Casp9 (Agnès et al., 2007) Nc (Bergman, 2006.7.7, Muro et al., 2006, Bergman, 2007.4.12, Jordan et al., 2005, Kornbluth and White, 2005, Zeitouni et al., 2007, Haerty et al., 2007, Begun et al., 2007, Chittaranjan et al., 2009, Dworkin et al., 2009, Kim et al., 2005, Terashima and Bownes, 2005, Wang et al., 2010) Nc\Dronc (Martin et al., 2007)
Name Synonym	Caspase-9-like (Fan and Bergmann, 2010) DRONC (Mills et al., 2006) dronc (Xu and Bergmann, 2007, Cakouros et al., 2008, Babcock et al., 2009, Neto-Silva et al., 2010) Dronc (Shapiro and Ryoo, 2008, Chew et al., 2009, Zhong and Belote, 2007, Koto et al., 2009, Du, 2010.4.23, Juhasz and Sass, 2005) Drosophila Nedd2-like caspase (Adrain, 2006) Nedd2-like caspase (Williams et al., 2006, Snipas et al., 2008, Martín et al., 2009, Truman et al., 2010) Nedd 2-like caspase (Terashima and Bownes, 2005)
Secondary FlyBase IDs
	FBgn0025326 FBgn0062102
References ( 284 )
Generate a list of	All references relating to this gene ( 284 )
List References by type	Research paper  ( 165 ) Supplementary material  ( 7 ) Review  ( 49 ) Personal communication to FlyBase  ( 8 ) Abstract  ( 44 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 2 ) Curated genome annotation  ( 2 ) Patent  ( 1 ) Computer file  ( 2 ) Automatic genome annotation  ( 1 )
Recent research papers ( 22 )
	Lee et al., 2011, J. Comp. Neurol. 519(1): 34--48 Drosophila caspases involved in developmentally regulated programmed cell death of peptidergic neurons during early metamorphosis. [FBrf0212368] Lee et al., 2011, PLoS Genet. 7(9): e1002261 Drosophila IAP1-Mediated Ubiquitylation Controls Activation of the Initiator Caspase DRONC Independent of Protein Degradation. [FBrf0215256] Li et al., 2011, Nat. Commun. 2: 408 Structural mechanisms of DIAP1 auto-inhibition and DIAP1-mediated inhibition of drICE. [FBrf0214630] Shukla and Tapadia, 2011, Europ. J. Cell Biol. 90(1): 72--80 Differential localization and processing of apoptotic proteins in Malpighian tubules of Drosophila during metamorphosis. [FBrf0212365] Suissa et al., 2011, J. Biol. Chem. 286(17): 15556--15564 The NAB-Brk Signal Bifurcates at JNK to Independently Induce Apoptosis and Compensatory Proliferation. [FBrf0213516] Tao and Rolls, 2011, J. Neurosci. 31(14): 5398--5405 Dendrites have a rapid program of injury-induced degeneration that is molecularly distinct from developmental pruning. [FBrf0213404] Yuan et al., 2011, Structure 19(1): 128--140 Structure of the Drosophila apoptosome at 6.9 å resolution. [FBrf0212736] Fan and Bergmann, 2010, Cell Death Differ. 17(3): 534--539 The cleaved-Caspase-3 antibody is a marker of Caspase-9-like DRONC activity in Drosophila. [FBrf0209949] Fan et al., 2010, Cell Death Differ. 17(6): 912--921 Dual roles of Drosophila p53 in cell death and cell differentiation. [FBrf0210741] Lennox and Stronach, 2010, Dev. Dyn. 239(2): 651--664 POSH misexpression induces caspase-dependent cell death in Drosophila. [FBrf0209862] Li et al., 2010, Cancer Cell 17(5): 469--480 Specific Killing of Rb Mutant Cancer Cells by Inactivating TSC2. [FBrf0210758] Lin et al., 2010, Development 137(1): 43--51 Lineage-specific effects of Notch/Numb signaling in post-embryonic development of the Drosophila brain. [FBrf0209573] Malzer et al., 2010, J. Cell Sci. 123(17): 2892--2900 Impaired tissue growth is mediated by checkpoint kinase 1 (CHK1) in the integrated stress response. [FBrf0211608] Menéndez et al., 2010, Proc. Natl. Acad. Sci. U.S.A. 107(33): 14651--14656 A tumor-suppressing mechanism in Drosophila involving cell competition and the Hippo pathway. [FBrf0211593] Mesquita et al., 2010, PLoS Biol. 8(12): e1000566 A dp53-Dependent Mechanism Involved in Coordinating Tissue Growth in Drosophila. [FBrf0212630] Neto-Silva et al., 2010, Dev. Cell 19(4): 507--520 Evidence for a Growth-Stabilizing Regulatory Feedback Mechanism between Myc and Yorkie, the Drosophila Homolog of Yap. [FBrf0212043] Paquette et al., 2010, Mol. Cell 37(2): 172--182 Caspase-Mediated Cleavage, IAP Binding, and Ubiquitination: Linking Three Mechanisms Crucial for Drosophila NF-kappaB Signaling. [FBrf0209837] Schoenmann et al., 2010, J. Neurosci. 30(18): 6375--6386 Axonal degeneration is regulated by the apoptotic machinery or a NAD+-sensitive pathway in insects and mammals. [FBrf0210748] Truman et al., 2010, Development 137(1): 53--61 Role of Notch signaling in establishing the hemilineages of secondary neurons in Drosophila melanogaster. [FBrf0209606] Wang et al., 2010, Dev. Dyn. 239(3): 954--964 Med24 and Mdh2 are required for Drosophila larval salivary gland cell death. [FBrf0210136] Wang et al., 2010, Dev. Dyn. 239(11): 2813--2827 Drosophila variable nurse cells encodes arrest defective 1 (ARD1), the catalytic subunit of the major N-terminal acetyltransferase complex. [FBrf0212164] Yang et al., 2010, EMBO J. 29(18): 3196--3207 Metabolic regulation of Drosophila apoptosis through inhibitory phosphorylation of Dronc. [FBrf0211843] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...