FlyBase Gene Report: Dmel\Hsp110

General Information

Symbol

Dmel\Hsp110

Species

D. melanogaster

Name

Heat shock protein 110

Annotation Symbol

CG6603

Feature Type

protein_coding_gene

FlyBase ID

FBgn0026418

Gene Model Status

Current

Stock Availability

19 publicly available

Gene Summary

Heat shock protein 110 (Hsp110) encodes an HSP110 family protein that interacts physically with the product of DnaJ-1 as a chaperone of misfolded proteins. It functions together with the product of DnaJ-1 to prevent the toxicity of aggregation-prone proteins. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

Hsc70Cb, Hsc70, dHsp110, l(3)07621, l(3)00082

Key Links

Genomic Location

Cytogenetic map

70C15-70C15

Sequence location

3L:14,037,019..14,043,686 [+]

Recombination map

3-41

RefSeq locus

NT_037436 REGION:14037019..14043686

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (11 terms)

Molecular Function (5 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (5 terms)

CV Term

Evidence

References

enables adenyl-nucleotide exchange factor activity

inferred from biological aspect of ancestor with PANTHER:PTN002900795

(GO Reference Genome Project, 2011-)

enables ATP binding

inferred from electronic annotation with InterPro:IPR013126

(InterPro Project Members, 2004-)

enables ATP hydrolysis activity

non-traceable author statement

(Easton et al., 2000)

enables ATP-dependent protein folding chaperone

inferred from electronic annotation with InterPro:IPR013126

(InterPro Project Members, 2004-)

enables denatured protein binding

inferred from sequence or structural similarity with UniProtKB:Q60446

(Easton et al., 2000)

Biological Process (3 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in cellular response to heat

inferred from sequence or structural similarity with UniProtKB:Q60446

(Easton et al., 2000)

involved_in chaperone-mediated protein complex assembly

inferred from sequence or structural similarity with UniProtKB:P34932

(Gene Ontology Curators, 2002-)

involved_in protein folding

inferred from biological aspect of ancestor with PANTHER:PTN000452854

(GO Reference Genome Project, 2011-)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

located_in cytoplasm

inferred from high throughput direct assay

(Lee et al., 2014)

located_in cytosol

inferred from high throughput direct assay

(Lye et al., 2014)

located_in nucleus

inferred from high throughput direct assay

(Lee et al., 2014)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

is_active_in cytosol

inferred from biological aspect of ancestor with PANTHER:PTN000452854

(GO Reference Genome Project, 2011-)

is_active_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN000452854

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

ATYPICAL HEAT SHOCK PROTEIN 70 CHAPERONES

Protein Family (UniProt)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

ATP hydrolysis activity
RHEA 13065:

Summaries

Gene Snapshot

Gene Group (FlyBase)

ATYPICAL HEAT SHOCK PROTEIN 70 CHAPERONES -: Atypical Heat Shock Proteins 70 (Hsp70-A) are co-chaperones, acting as nucleotide exchange factors for canonical Hsp70s and holdases, binding to protein folding intermediates. Hsc70Cb and CG2918 are classed as atypical Hsp70 protein chaperones and belonging to the Hsp110 and Grp170 subfamilies, respectively. (Adapted from FBrf0232270, PMID:26913285 and PMID:17441502).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Hsp110 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry M9MSL3)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.46

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Hsp110-RA

FBtr0075771

NM_140430

3187

804

Hsp110-RB

FBtr0075772

NM_168573

3162

804

Hsp110-RC

FBtr0075773

NM_168574

3292

804

Hsp110-RE

FBtr0304034

NM_001202172

3184

804

Hsp110-RF

FBtr0304035

NM_001202173

3159

804

Hsp110-RG

FBtr0304036

NM_001202174

3283

836

Hsp110-RH

FBtr0304037

NM_001202175

3258

836

Hsp110-RI

FBtr0333051

NM_001274893

3590

804

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Hsp110-PA

FBpp0075513

88.5

804

5.07

FBpp0075514

88.5

804

5.07

FBpp0075515

88.5

804

5.07

FBpp0292997

88.5

804

5.07

FBpp0292998

88.5

804

5.07

FBpp0292999

91.9

836

5.00

FBpp0293000

91.9

836

5.00

FBpp0305265

88.5

804

5.07

Q9VUC1

NP_001261822

AGB94515

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

804 aa isoforms: Hsp110-PA, Hsp110-PB, Hsp110-PC, Hsp110-PE, Hsp110-PF, Hsp110-PI

836 aa isoforms: Hsp110-PG, Hsp110-PH

Additional Polypeptide Data and Comments

Reported size (kDa)

804 (aa); 89 (kD predicted)

(Burmester et al., 2000)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Hsp110 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.82

Transcript Expression

distribution deduced from reporter

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

gastric caecum

(Burmester et al., 2000)

embryonic/larval hindgut

(Burmester et al., 2000)

larval brain

(Burmester et al., 2000)

Malpighian tubule

(Burmester et al., 2000)

embryonic/larval midgut

(Burmester et al., 2000)

embryonic/larval proventriculus

(Burmester et al., 2000)

imaginal disc

(Burmester et al., 2000)

embryonic/larval salivary gland

(Burmester et al., 2000)

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic brain

(Fisher et al., 2012)

embryonic/larval midgut

(Fisher et al., 2012)

larval ventral nerve cord

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

day 7 of adulthood -- day 49 of adulthood

adult heart

(Cammarato et al., 2011)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in cytoplasm

inferred from high throughput direct assay

(Lee et al., 2014)

located_in cytosol

inferred from high throughput direct assay

(Lye et al., 2014)

located_in nucleus

inferred from high throughput direct assay

(Lee et al., 2014)

Expression Deduced from Reporters

Reporter: P{ST.lexA::HG}Hsp110^SE430

Stage

Tissue/Position (including subcellular localization)

Reference

wandering third instar larval stage

larval ventral nerve cord

(Bloomington Drosophila Stock Center, 2019)

Reporter: PBac{754.P.FSVS-0}Hsp110^CPTI002201

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

fan-shaped body

(Knowles-Barley, 2011.8.24)

adult antennal lobe

(Knowles-Barley, 2011.8.24)

adult brain cell body rind

(Knowles-Barley, 2011.8.24)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Hsp110 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Hsp110

View exonic expression by tissue for Dmel\Hsp110

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0026418

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

39557/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0026418

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0026418

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0026418

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG6603

Flygut - An atlas of the Drosophila adult midgut

FBgn0026418

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 31 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 8 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Hsp110

Transgenic constructs containing regulatory region of Hsp110

Aberrations (Deficiencies and Duplications) ( 10 )

Inferred from experimentation ( 10 )

Gene disrupted in

Df(3L)D-1rv16

(Burmester et al., 2000, Carpenter, 1994)

Df(3L)D-5rv6

(Burmester et al., 2000, Carpenter, 1994)

Df(3L)fz-CAL5

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Df(3L)fz-GF3b

(Burmester et al., 2000, Spradling et al., 1999, Szeged Stock Center, 1998-, Deak et al., 1997, BDGP Project Members, 1994-1999, Carpenter, 1994)

Gene not disrupted in

Df(3L)D-4rv34

(Carpenter, 1994)

Df(3L)fz-D21

(Burmester et al., 2000, BDGP Project Members, 1994-1999, Carpenter, 1994)

Df(3L)fz-GS1a

(Burmester et al., 2000, Spradling et al., 1999, BDGP Project Members, 1994-1999, Carpenter, 1994)

Df(3L)fz-M21

(Burmester et al., 2000, Spradling et al., 1999, BDGP Project Members, 1994-1999, Carpenter, 1994)

Df(3L)J40

(Burmester et al., 2000)

Gene partially disrupted in

Df(3L)Frl^Ex83

(Dollar et al., 2016)

Inferred from location ( 7 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal

Hsp110^CB02656

lethal, with Scer\GAL4^29BD

Hsp110^GS3087

lethal, with Scer\GAL4^Act5C.PI

Hsp110^GD11973

lethal, with Scer\GAL4^c355

Hsp110^GS3087

lethal, with Scer\GAL4^hs.2sev

Hsp110^GS3087

lethal (with Df(3L)fz-GF3b)

lethal | recessive

lethal - all die before end of larval stage | recessive

Hsp110^S134802

lethal - all die before end of pupal stage | recessive

Hsp110¹

lethal - all die during embryonic stage | recessive

partially lethal - majority die, with Scer\GAL4^pnr-MD237

Hsp110^GD11973

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Hsp110^GD11973

viable, with Scer\GAL4^Mef2.PR

Hsp110^GD11973

viable, with Scer\GAL4^tin.CΔ4

Hsp110^GD11973

Other Phenotypes

Allele

flightless, with Scer\GAL4^Mef2.PR

Hsp110^GD11973

some die during embryonic stage | recessive

some die during larval stage | recessive

Hsp110^S134802

some die during pupal stage, with Scer\GAL4^pnr-MD237

Hsp110^GD11973

some die during pupal stage | recessive

Hsp110¹

visible, with Scer\GAL4^dpp.blk1

Hsp110^GS3087

visible, with Scer\GAL4^pnr-MD237

Hsp110^GD11973

Phenotype manifest in

Allele

arista, with Scer\GAL4^dpp.blk1

Hsp110^GS3087

eye, with Scer\GAL4^ey.PH

Hsp110^GD11973

mesonotum, with Scer\GAL4^pnr-MD237

Hsp110^GD11973

trichogen cell, with Scer\GAL4^pnr-MD237

Hsp110^GD11973

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (19)

Hsap\HSPA4

14 of 14

Yes

Hsap\HSPA4L

13 of 14

Yes

Hsap\HSPH1

13 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

1 of 14

Yes

Hsap\HSPA7

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (17)

Rnor\Hspa4

14 of 14

Yes

Rnor\Hsph1

13 of 14

Yes

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mus musculus (laboratory mouse) (16)

Mmus\Hspa4

14 of 14

Yes

Mmus\Hsph1

13 of 14

Yes

Mmus\Hspa4l

12 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (14)

Xtro\hspa4

7 of 13

Yes

Xtro\hsph1

7 of 13

Yes

Xtro\c7

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\timeless

1 of 13

Xtro\tut7

1 of 13

Xtro\XB5934250

1 of 13

Danio rerio (Zebrafish) (21)

Drer\hspa4a

14 of 14

Yes

Drer\hspa4b

14 of 14

Yes

Drer\hsph1

13 of 14

Yes

Drer\hspa4l

12 of 14

Yes

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (11)

Cele\hsp-110

14 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (11)

Agam\AgaP_AGAP010331

12 of 12

Yes

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (21)

Atha\Hsp70-15

13 of 13

Yes

Atha\HSP91

13 of 13

Yes

Atha\AT1G11660

12 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (14)

Scer\SSE1

13 of 13

Yes

Scer\SSE2

12 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

Schizosaccharomyces pombe (Fission yeast) (8)

Spom\pss1

12 of 12

Yes

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

Escherichia coli (enterobacterium) (4)

Ecol\dnaK

1 of 11

Yes

Ecol\hscA

1 of 11

Yes

Ecol\hscC

1 of 11

Yes

Ecol\yegD

1 of 11

Yes

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Hsp110. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (14)

4 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

2 of 13

2 of 13

2 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 10 )

Allele

Disease

Interaction

References

Hsp110^HMS01080

exacerbates neurodegenerative disease

modeled by Zzzz\CAG^{127Q.UAS.Tag:HA}, DnaJ-1^UAS.cKb

(Kuo et al., 2013)

modeled by Zzzz\CAG^{127Q.UAS.Tag:HA}

(Kuo et al., 2013)

Hsp110^UAS.cKa

ameliorates neurodegenerative disease

modeled by Zzzz\CAG^{127Q.UAS.Tag:HA}, DnaJ-1^UAS.cKb

(Kuo et al., 2013)

ameliorates Huntington's disease

modeled by Hsap\HTT^GMR.Q120, DnaJ-1^UAS.cKb

(Kuo et al., 2013)

modeled by Hsap\HTT^{N548.Q128.UAS}

(Martin et al., 2021)

Hsp110⁰⁰⁰⁸²

exacerbates neurodegenerative disease

modeled by Hsap\HTT^Q93.ex1.UAS

(Zhang et al., 2010)

exacerbates Huntington's disease

modeled by Hsap\HTT^{128Q.1-336.UAS}

(Al-Ramahi et al., 2018)

Hsp110^S004112

exacerbates neurodegenerative disease

modeled by Hsap\HTT^Q93.ex1.UAS

(Zhang et al., 2010)

Hsp110^S031820

exacerbates neurodegenerative disease

modeled by Hsap\HTT^Q93.ex1.UAS

(Zhang et al., 2010)

Hsp110^S064906

exacerbates neurodegenerative disease

modeled by Hsap\HTT^Q93.ex1.UAS

(Zhang et al., 2010)

Hsp110^d03562

ameliorates amyotrophic lateral sclerosis type 6

modeled by Hsap\FUS^{R521C.UAS.Tag:HA}

(Kankel et al., 2020)

ameliorates amyotrophic lateral sclerosis type 10

modeled by Hsap\TARDBP^{M337V.UAS.Tag:MYC}

(Kankel et al., 2020)

ameliorates frontotemporal dementia and/or amyotrophic lateral sclerosis 4

modeled by Zzzz\GGGGCC^30.UAS.EGFP

(Kankel et al., 2020)

Hsp110^UAS.cZa

ameliorates neurodegenerative disease

modeled by Hsap\HTT^Q93.ex1.UAS

(Zhang et al., 2010)

Hsp110^EY00671

exacerbates Huntington's disease

modeled by Hsap\HTT^{128Q.1-336.UAS}

(Al-Ramahi et al., 2018)

Hsp110^NIG.6603R

exacerbates frontotemporal dementia and/or amyotrophic lateral sclerosis 1

modeled by Zzzz\poly-GR^PO-36.UAS

(Park et al., 2021)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

HSPA4; heat shock protein family A (Hsp70) member 4

14 of 14

601113

HSPA4L; heat shock protein family A (Hsp70) member 4 like

13 of 14

619077

HSPH1; heat shock protein family H (Hsp110) member 1

13 of 14

610703

HSPA1A; heat shock protein family A (Hsp70) member 1A

3 of 14

140550

HSPA1B; heat shock protein family A (Hsp70) member 1B

3 of 14

603012

HSPA1L; heat shock protein family A (Hsp70) member 1 like

3 of 14

140559

HSPA6; heat shock protein family A (Hsp70) member 6

3 of 14

140555

HSPA8; heat shock protein family A (Hsp70) member 8

3 of 14

600816

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Show neighbor-neighbor interactions:

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(data from AllianceMine provided by esyN)

Select Layout:

Force Directed

Circle

Concentric

Legend:

Protein

RNA

Selected Interactor(s)

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Hsp110 - Acaa

experimental knowledge based

(Guruharsha et al., 2011)

Hsp110 - Akap200

experimental knowledge based

(Guruharsha et al., 2011)

Hsp110 - AnxB10

experimental knowledge based

(Guruharsha et al., 2011)

Hsp110 - Ar2

experimental knowledge based

(Guruharsha et al., 2011)

Hsp110 - CG14715

experimental knowledge based

(Guruharsha et al., 2011)

Hsp110 - Calr

experimental knowledge based

(Guruharsha et al., 2011)

Hsp110 - Chd64

experimental knowledge based

(Guruharsha et al., 2011)

Hsp110 - Cndp2

experimental knowledge based

(Guruharsha et al., 2011)

Hsp110 - Cs1

experimental knowledge based

(Guruharsha et al., 2011)

Hsp110 - Df31

experimental knowledge based

(Guruharsha et al., 2011)

Hsp110 - DnaJ-1

anti bait coimmunoprecipitation, western blot

(Kuo et al., 2013)

Hsp110 - EndoGI

experimental knowledge based

(Guruharsha et al., 2011)

Hsp110 - Eno

experimental knowledge based

(Guruharsha et al., 2011)

Hsp110 - Fkbp14

experimental knowledge based

(Guruharsha et al., 2011)

Hsp110 - Gdi

experimental knowledge based

(Guruharsha et al., 2011)

Hsp110 - HINT1

experimental knowledge based

(Guruharsha et al., 2011)

Hsp110 - Inos

experimental knowledge based

(Guruharsha et al., 2011)

Hsp110 - Moe

experimental knowledge based

(Guruharsha et al., 2011)

Hsp110 - Nacα

experimental knowledge based

(Guruharsha et al., 2011)

Hsp110 - Prx6c

experimental knowledge based

(Guruharsha et al., 2011)

Hsp110 - Sh3β

experimental knowledge based

(Guruharsha et al., 2011)

Hsp110 - Stip1

experimental knowledge based

(Guruharsha et al., 2011)

Hsp110 - TER94

experimental knowledge based

(Guruharsha et al., 2011)

Hsp110 - Tkt

experimental knowledge based

(Guruharsha et al., 2011)

Hsp110 - awd

experimental knowledge based

(Guruharsha et al., 2011)

Hsp110 - cib

experimental knowledge based

(Guruharsha et al., 2011)

Hsp110 - flr

experimental knowledge based

(Guruharsha et al., 2011)

Hsp110 - orb2

anti bait coimmunoprecipitation, anti tag western blot

(Desai et al., 2024)

Hsp110 - regucalcin

experimental knowledge based

(Guruharsha et al., 2011)

Summary of Genetic Interactions

esyN Network Diagram

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

esyN Network Key:

Suppression

Enhancement

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

DnaJ-1

suppressible

Hsp110

(Kuo et al., 2013)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0026418

MIST (protein-protein) - An integrated Molecular Interaction Database

39557

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Protein processing in endoplasmic reticulum

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-41

Cytogenetic map

70C15-70C15

Sequence location

3L:14,037,019..14,043,686 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

70C15-70C15

Limits computationally determined from genome sequence between P{EP}EP3561^EP3561 and P{PZ}l(3)70Da⁰²⁴⁰²&P{PZ}btl⁰⁰²⁰⁸

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

70C-70C

(determined by in situ hybridisation)

(Burmester et al., 2000)

70C-70C

(Mink, 1999.2.5, Mink, 1999.2.5)

70C12-70C13

(Burmester, 1999.3.1)

70C12-70C13

(determined by in situ hybridisation) 70D1--2 (determined by in situ hybridisation)

(Spradling et al., 1999)

70C-70C

(determined by in situ hybridisation) 70D1--2 (determined by in situ hybridisation) 70C (determined by in situ hybridisation)

(Szeged Stock Center, 1998-, Deak et al., 1997)

70C12-70C13

70D1--2

(BDGP Project Members, 1994-1999)

Location 70D1--2inferred from insertion in: Hsc70Cb^S134802

(Deak et al., 1997)

Experimentally Determined Recombination Data

Location

3-41

(FlyBase, 2016)

3-35.6

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (19)

Genomic Clones (11)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (127)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD32979

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0026418

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0026418

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Kuo et al., 2013)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Host gene for maternally inherited stable intronic sequence RNA (sisRNA).

(Tay and Pek, 2017)

Candidate stable intronic sequence RNA (sisRNA) identified within CDS of this gene.

(Pek et al., 2015)

dsRNA made from templates generated with primers directed against this gene results in a change in cell proliferation and cell size.

(Guertin et al., 2006)

Area matching Drosophila EST AI295731. This EST forms a 2018bp contig with ESTs AI258429, AA696170, AI109519 and AA391348, and has sequence similarity to Mouse APG-1 gene.

(Davies, 2001.3.15)

Relationship to Other Genes

Source for database merge of

Source for merge of: Hsc70Cb l(3)70Ca l(3)S148513 l(3)S134217 l(3)00082

(Maroy, 1999.4.20)

Source for merge of: Hsc70Cb BEST:LD32772

(Bayraktaroglu, 2000.11.2)

Source for merge of: Hsc70Cb anon-WO0118547.302

(Burmester et al., 2000, FlyBase, 1996-)

Additional comments

Source for merge of Hsc70Cb anon-WO0118547.302 was sequence comparison ( date:051113 ).

(Burmester et al., 2000, FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: Hsp110 Hsc70Cb

(Easton et al., 2000)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (33)

Reported As

Symbol Synonym

0041/12

(Deak et al., 1997)

0318/20

(Deak et al., 1997)

1342/17

(Deak et al., 1997)

1348/02

(Deak et al., 1997)

1485/13

(Deak et al., 1997)

BEST:LD32772

CG6603

(Kolkhof et al., 2017, Meadows, 2017.1.11, Raut et al., 2017, Tay and Pek, 2017, Çiçek et al., 2016, Hosono et al., 2015, Pek et al., 2015, Christis and Munro, 2012, Cammarato et al., 2011, Monzo et al., 2010, Müller et al., 2010, Ni et al., 2010.12.1, Zhang et al., 2010, Rival et al., 2009, Quinones-Coello, 2007, Quinones-Coello, 2007)

HSC-70

(Richmond and Broadie, 2002)

HSC-70cb

(Yeh et al., 2018)

HSC70

(Folk et al., 2006, Gunawardena et al., 2003)

HSC70cb

(Kuo et al., 2013)

HSP110

(Kuo et al., 2013)

HSP110-1

(Nikolaidis and Nei, 2004)

Hsc70

(Fredriksson et al., 2012, Wellington and Zinsmaier, 2005, Tatar et al., 2003)

Hsc70CB

(Zhang et al., 2021)

Hsc70Cb

(Deo et al., 2024, Desai et al., 2024, Heigwer et al., 2023, Na et al., 2023, Titlow et al., 2023, Kaneko, 2022, Kong et al., 2022, Perlegos et al., 2022, Ribot et al., 2022, Thackray et al., 2022, Martin et al., 2021, Park et al., 2021, Silva et al., 2021, Kankel et al., 2020, Kockel et al., 2019, Al-Ramahi et al., 2018, Gene Disruption Project members, 2018-, Podolsky et al., 2018, Galluzzi et al., 2017, Hsu and Drummond-Barbosa, 2017, Noble et al., 2016, Dent et al., 2015, Jones and Macdonald, 2015, Ashwal-Fluss et al., 2014, Lee et al., 2014, Luck et al., 2014, Vinayagam et al., 2014, Kwon et al., 2013, Gistelinck et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Franco et al., 2011, Monzo et al., 2010, Müller et al., 2010, Takemori and Yamamoto, 2009, Beckstead et al., 2007, Blard et al., 2007, Buszczak et al., 2007, Quinones-Coello, 2007, Quinones-Coello, 2007, Stuart et al., 2007, Guertin et al., 2006, Birch-Machin et al., 2005, Kiss et al., 2005)

Hsc70cb

(Yakubu and Morano, 2021)

Hsp110

(Easton et al., 2000)

LD32772

(Toba et al., 1999)

anon-WO0118547.302

dHsp110

(Thackray et al., 2022, Xu et al., 2015, Zhang et al., 2010)

hsc70Cb

(Neal et al., 2006, Burmester, 1999.3.1)

hsc70cb

(Tay and Pek, 2017, Pek et al., 2015, Kuo et al., 2013)

l(3)00082

(Spradling et al., 1999)

l(3)07621

(Maroy, 1999.4.20)

l(3)134217

(Mink, 1999.2.5)

l(3)148513

(Mink, 1999.2.5)

l(3)70Ca

(Burmester et al., 2000)

l(3)70Cb

(Maroy, 1999.4.20)

l(3)S134217

l(3)S134802

l(3)S148513

Name Synonyms

Heat shock protein 110

Hsc70Cb

(Cammarato et al., 2011, Takemori and Yamamoto, 2009)

Secondary FlyBase IDs

FBgn0010707
FBgn0010924
FBgn0013562
FBgn0026569
FBgn0027982
FBgn0028258
FBgn0028259
FBgn0062110

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 84 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

39557

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

M9MSL3

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

M9MSL3

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0026418

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

39557/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0026418

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0026418

FlyMine - An integrated database for Drosophila genomics

FBgn0026418

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG6603

MARRVEL_MODEL - MARRVEL (model organism gene)

39557

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0026418

DroID - A comprehensive database of gene and protein interactions.

FBgn0026418

DRSC - Results frm RNAi screens

FBgn0026418

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0026418

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0026418

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG6603

Flygut - An atlas of the Drosophila adult midgut

FBgn0026418

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0026418

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC007971

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Protein processing in endoplasmic reticulum

MIST (protein-protein) - An integrated Molecular Interaction Database

39557

References (131)

The following external sites may use different assemblies or annotations than FlyBase.

0.82

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