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Gene Dmel\Hsc70Cb

General Information
Symbol	Dmel\Hsc70Cb	Species	D. melanogaster
Name	Hsc70Cb	Annotation symbol	CG6603
Feature type	protein_coding_gene	FlyBase ID	FBgn0026418
Gene Model Status	Current	Stock availability	15 publicly available
Also Known As	Hsc70
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	70C15-70C15	Sequence location	3L:14,030,119..14,036,786 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Hsc70Cb is referred to in FlyBase by the symbol Dmel\Hsc70Cb (CG6603, FBgn0026418). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: chaperone binding. Based on sequence similarity, it is predicted to be involved in the biological process: protein folding. 30 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; mesothoracic tergum; arista. It has 8 annotated transcripts and 8 annotated polypeptides. Protein features are: Heat shock protein 70 family; Heat shock protein 70, conserved site. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 00-06 hour embryonic stages, during early larval stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1636741_s_at completely aligns to an exonic region common to each of the 3 FlyBase-annotated transcript isoforms of Hsc70Cb. Gene sequence location is 3L:14030119..14036786.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 70C15-70C15   Limits computationally determined from genome sequence between P{EP}EP3561EP3561 and P{PZ}l(3)70Da02402&P{PZ}btl00208
Experimentally Determined Cytological Location
Cytogenetic map Notes References 70C-70C   (determined by in situ hybridisation)   (Burmester et al., 2000) 70C-70C     (Mink, 1999.2.5) 70C-70C     (Mink, 1999.2.5) 70C12-70C13     (Burmester, 1999.3.1) 70C12-70C13   (determined by in situ hybridisation) 70D1--2 (determined by in situ hybridisation)   (Spradling et al., 1999) 70C-70C   (determined by in situ hybridisation) 70D1--2 (determined by in situ hybridisation) 70C (determined by in situ hybridisation)   (Szeged Stock Center, 1998-) 70C12-70C13   70D1--2   (BDGP Project Members, 1994-1999) 70C-70C   Location 70D1--2inferred from insertion in: Hsc70CbS134802(determined by in situ hybridisation) 70D1--2 (determined by in situ hybridisation) 70C (determined by in situ hybridisation)   (Deak et al., 1997)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Hsc70Cb for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.46 Low-frequency RNA-Seq exon junction(s) not annotated. Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Hsc70Cb-RA FBtr0075771  NM_140430   3187   804 Hsc70Cb-RB FBtr0075772  NM_168573   3162   804 Hsc70Cb-RC FBtr0075773  NM_168574   3292   804 Hsc70Cb-RE FBtr0304034  NM_001202172   3184   804 Hsc70Cb-RF FBtr0304035  NM_001202173   3159   804 Hsc70Cb-RG FBtr0304036  NM_001202174   3283   836 Hsc70Cb-RH FBtr0304037  NM_001202175   3258   836 Hsc70Cb-RI FBtr0333051  NM_001274893   3590   804
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Hsc70Cb-PA   FBpp0075513   88.5   804   5.07     NP_648687   AAF49766 Hsc70Cb-PB   FBpp0075514   88.5   804   5.07     NP_729951   AAF49767 Hsc70Cb-PC   FBpp0075515   88.5   804   5.07     NP_729952   AAN11823 Hsc70Cb-PE   FBpp0292997   88.5   804   5.07     NP_001189101   ADV37537 Hsc70Cb-PF   FBpp0292998   88.5   804   5.07     NP_001189102   ADV37538 Hsc70Cb-PG   FBpp0292999   91.9   836   5.00     NP_001189103   ADV37539 Hsc70Cb-PH   FBpp0293000   91.9   836   5.00     NP_001189104   ADV37540 Hsc70Cb-PI   FBpp0305265   88.5   804   5.07     NP_001261822   AGB94515
Additional Polypeptide Data & Comments
Reported size (kDa)	804 (aa); 89 (kD predicted) (Burmester et al., 2000)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Heat shock protein 70, conserved site (IPR018181) Heat shock protein 70 family (IPR013126)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA391348   AA391918   AA540604   AA694877   AA695663   AA696170   AA697561   AA698700   AA938851   AA951892   AA978811   AE014296 AAF49766   AE014296 AAF49767   AE014296 AAN11823   AE014296 ADV37537   AE014296 ADV37538   AE014296 ADV37539   AE014296 ADV37540   AE014296 AGB94515   AI062572   AI062721   AI062791   AI107499   AI109519   AI133940   AI134877   AI257282   AI258104   AI258429   AI293511   AI295472   AI295731   AI297560   AI404342   AI405544   AI513379   AI513476   AI534102   AI541718   AI542331   AI544033   AI945915   AI946241   AJ132807   AJ132808   AJ132811 CAA10789   AJ132812   AJ132829 CAB38172   AQ026227   AW943157   AX094178   AY058632 AAL13861   BF490609   BF491918   BF492053   BF495261   BF501476   BG637687   BG639068   BI164776   BI212476   BI232832   BI237984   BI239399   BI352009   BI353934   BI362737   BI371392   BI374432   BI483406   BI632560   BI633805   BI637211   BP540330   BP544986   BP544987   BQ103164   BZ286270   CK132441   CK604583   CK604584   CK605398   CK605399   CK657695   CK660657   CK662149   CO154044   CO285378   CO286234   CO289701   CO294442   CO297497   CO305810   CO308116   CO310982   CO338061   CO340745   CZ469503   CZ473426   CZ473427   CZ474933   CZ475991   EC063975   EC064742   EC073279   EC085207   EC199892   EC208735   EC230711   EC237929   EC238159   EC245714   EC255881   EC261861   EC264073   EC266182   EV585522   EV586311   EV588392   EV589857   EV592485   EV594140   G00462   GH750008   GH750696   GH754643   GH756087   GH757788   GH759077   GH771925   GH776014   GH783475   GH784981   GH790441   GH795300   GH803351   GH804144   GH813379   GH816911   GH822918   GH828229   GH830108   GH833480   GH838326   GH847167   GH857964   GH860123   GH869068   GH871020   GH875281   GH881684   GH887757   GH892090   GH893914   GH895097   GH895551   GH901939   GH903723   GH908012   GH909214   GH916116   GH919499   GH920664   GH922276   GH923402   GH931937   GH934643   GH937631   GH939185
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VUC1 Q9XZT5 O96818
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
distribution deduced from reporter Stage Tissue/Position (including subcellular localization) Reference third instar larval stage   gastric caecum   (Burmester et al., 2000) embryonic/larval hindgut   (Burmester et al., 2000) embryonic/larval brain   (Burmester et al., 2000) Malpighian tubule   (Burmester et al., 2000) embryonic/larval midgut   (Burmester et al., 2000) embryonic/larval proventriculus   (Burmester et al., 2000) imaginal disc   (Burmester et al., 2000) embryonic/larval salivary gland   (Burmester et al., 2000) in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 13 -- 16   embryonic brain   (Fisher et al., 2012) embryonic/larval midgut   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    474.175 Larval Midgut    324.9 Larval Hindgut    393.7 Larval Malpighian Tubules    341.9 Larval Fat Body    227.9 Larval Salivary Gland    424.8 Larval Trachea    278.05 Larval Carcass    403.1 Adult Head    225.1 Adult Eye    211.525 Adult Brain    187.9 Adult Thoracic-Abdominal Ganglion    196.6 Adult Crop    312.2 Adult Midgut    261.9 Adult Hindgut    261.6 Adult Malpighian Tubules    328.9 Adult Fat Body    449.9 Adult Salivary Gland    288.4 Adult Heart    388.825 Adult VirginFemale Spermatheca    393 Adult InseminatedFemale Spermatheca    393.5 Adult Ovary    637.9 Adult Testis    251.9 Adult Male Accessory Gland    296.9 Adult Carcass    297.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    474.175 Larval Midgut    324.9 Larval Hindgut    393.7 Larval Malpighian Tubules    341.9 Larval Fat Body    227.9 Larval Salivary Gland    424.8 Larval Trachea    278.05 Larval Carcass    403.1 Adult Head    225.1 Adult Eye    211.525 Adult Brain    187.9 Adult Thoracic-Abdominal Ganglion    196.6 Adult Crop    312.2 Adult Midgut    261.9 Adult Hindgut    261.6 Adult Malpighian Tubules    328.9 Adult Fat Body    449.9 Adult Salivary Gland    288.4 Adult Heart    388.825 Adult VirginFemale Spermatheca    393 Adult InseminatedFemale Spermatheca    393.5 Adult Ovary  (637.9) Adult Testis    251.9 Adult Male Accessory Gland    296.9 Adult Carcass    297.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    474.175 Larval Midgut    324.9 Larval Hindgut    393.7 Larval Malpighian Tubules    341.9 Larval Fat Body    227.9 Larval Salivary Gland    424.8 Larval Trachea    278.05 Larval Carcass    403.1 Adult Head    225.1 Adult Eye    211.525 Adult Brain    187.9 Adult Thoracic-Abdominal Ganglion    196.6 Adult Crop    312.2 Adult Midgut    261.9 Adult Hindgut    261.6 Adult Malpighian Tubules    328.9 Adult Fat Body    449.9 Adult Salivary Gland    288.4 Adult Heart    388.825 Adult VirginFemale Spermatheca    393 Adult InseminatedFemale Spermatheca    393.5 Adult Ovary    637.9 Adult Testis    251.9 Adult Male Accessory Gland    296.9 Adult Carcass    297.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    474.175 Larval Midgut    324.9 Larval Hindgut    393.7 Larval Malpighian Tubules    341.9 Larval Fat Body    227.9 Larval Salivary Gland    424.8 Larval Trachea    278.05 Larval Carcass    403.1 Adult Head    225.1 Adult Eye    211.525 Adult Brain    187.9 Adult Thoracic-Abdominal Ganglion    196.6 Adult Crop    312.2 Adult Midgut    261.9 Adult Hindgut    261.6 Adult Malpighian Tubules    328.9 Adult Fat Body    449.9 Adult Salivary Gland    288.4 Adult Heart    388.825 Adult VirginFemale Spermatheca    393 Adult InseminatedFemale Spermatheca    393.5 Adult Ovary    637.9 Adult Testis    251.9 Adult Male Accessory Gland    296.9 Adult Carcass    297.3 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    474.175 Larval Midgut    324.9 Larval Hindgut    393.7 Larval Malpighian Tubules    341.9 Larval Fat Body    227.9 Larval Salivary Gland    424.8 Larval Trachea    278.05 Larval Carcass    403.1 Adult Head    225.1 Adult Eye    211.525 Adult Brain    187.9 Adult Thoracic-Abdominal Ganglion    196.6 Adult Crop    312.2 Adult Midgut    261.9 Adult Hindgut    261.6 Adult Malpighian Tubules    328.9 Adult Fat Body    449.9 Adult Salivary Gland    288.4 Adult Heart    388.825 Adult VirginFemale Spermatheca    393 Adult InseminatedFemale Spermatheca    393.5 Adult Ovary    637.9 Adult Testis    251.9 Adult Male Accessory Gland    296.9 Adult Carcass    297.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    474.175 Larval Midgut    324.9 Larval Hindgut    393.7 Larval Malpighian Tubules    341.9 Larval Fat Body    227.9 Larval Salivary Gland    424.8 Larval Trachea    278.05 Larval Carcass    403.1 Adult Head    225.1 Adult Eye    211.525 Adult Brain    187.9 Adult Thoracic-Abdominal Ganglion    196.6 Adult Crop    312.2 Adult Midgut    261.9 Adult Hindgut    261.6 Adult Malpighian Tubules    328.9 Adult Fat Body    449.9 Adult Salivary Gland    288.4 Adult Heart    388.825 Adult VirginFemale Spermatheca    393 Adult InseminatedFemale Spermatheca    393.5 Adult Ovary  637.9 Adult Testis    251.9 Adult Male Accessory Gland    296.9 Adult Carcass    297.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    474.175 Larval Midgut    324.9 Larval Hindgut    393.7 Larval Malpighian Tubules    341.9 Larval Fat Body    227.9 Larval Salivary Gland    424.8 Larval Trachea    278.05 Larval Carcass    403.1 Adult Head    225.1 Adult Eye    211.525 Adult Brain    187.9 Adult Thoracic-Abdominal Ganglion    196.6 Adult Crop    312.2 Adult Midgut    261.9 Adult Hindgut    261.6 Adult Malpighian Tubules    328.9 Adult Fat Body    449.9 Adult Salivary Gland    288.4 Adult Heart    388.825 Adult VirginFemale Spermatheca    393 Adult InseminatedFemale Spermatheca    393.5 Adult Ovary    637.9 Adult Testis    251.9 Adult Male Accessory Gland    296.9 Adult Carcass    297.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    474.175 Larval Midgut    324.9 Larval Hindgut    393.7 Larval Malpighian Tubules    341.9 Larval Fat Body    227.9 Larval Salivary Gland    424.8 Larval Trachea    278.05 Larval Carcass    403.1 Adult Head    225.1 Adult Eye    211.525 Adult Brain    187.9 Adult Thoracic-Abdominal Ganglion    196.6 Adult Crop    312.2 Adult Midgut    261.9 Adult Hindgut    261.6 Adult Malpighian Tubules    328.9 Adult Fat Body    449.9 Adult Salivary Gland    288.4 Adult Heart    388.825 Adult VirginFemale Spermatheca    393 Adult InseminatedFemale Spermatheca    393.5 Adult Ovary    637.9 Adult Testis    251.9 Adult Male Accessory Gland    296.9 Adult Carcass    297.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    225.1   NA  Eye    211.525   NA  Brain    187.9   474.175  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    196.6   NA  Crop    312.2   324.9  Midgut    261.9   393.7  Hindgut    261.6   341.9  Malpighian Tubules    328.9   227.9  Fat Body    449.9   424.8  Salivary Gland    288.4   NA  Heart    388.825   278.05  Trachea    NA   NA  VirginFemale Spermatheca    393   NA  InseminatedFemale Spermatheca    393.5   NA  Ovary    637.9   NA  Testis    251.9   NA  Male Accessory Gland    296.9   403.1  Carcass    297.3 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    121 central nervous system, larvae L3    122 central nervous system, pupae P8    76 head, virgin 1-day female    37 head, virgin 4-day female    34 head, virgin 20-day female    30 head, mated 1-day female    32 head, mated 4-day female    51 head, mated 20-day female    32 head, mated 1-day male    41 head, mated 4-day male    46 head, mated 20-day male    52 salivary gland, larvae L3 wandering    12 salivary gland, white prepupae    33 digestive system, larvae L3 wandering    57 digestive system, 1-day adult    42 digestive system, 4-day adult    73 digestive system, 20-day adult    53 fat body, larvae L3 wandering    20 fat body, white prepupae    48 fat body, pupae P8    54 carcass, larvae L3 wandering    110 carcass, 1-day adult    46 carcass, 4-day adult    63 carcass, 20-day adult    51 ovary, virgin 4-day female    186 ovary, mated 4-day female    168 testis, mated 4-day male    98 accessory gland, mated 4-day male    35 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (121) central nervous system, larvae L3  (122) central nervous system, pupae P8  (76) head, virgin 1-day female  (37) head, virgin 4-day female  (34) head, virgin 20-day female  (30) head, mated 1-day female  (32) head, mated 4-day female  (51) head, mated 20-day female  (32) head, mated 1-day male  (41) head, mated 4-day male  (46) head, mated 20-day male  (52) salivary gland, larvae L3 wandering    12 salivary gland, white prepupae  (33) digestive system, larvae L3 wandering  (57) digestive system, 1-day adult  (42) digestive system, 4-day adult  (73) digestive system, 20-day adult  (53) fat body, larvae L3 wandering    20 fat body, white prepupae  (48) fat body, pupae P8  (54) carcass, larvae L3 wandering  (110) carcass, 1-day adult  (46) carcass, 4-day adult  (63) carcass, 20-day adult  (51) ovary, virgin 4-day female  (186) ovary, mated 4-day female  (168) testis, mated 4-day male  (98) accessory gland, mated 4-day male  (35) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (121) central nervous system, larvae L3  (122) central nervous system, pupae P8    76 head, virgin 1-day female    37 head, virgin 4-day female    34 head, virgin 20-day female    30 head, mated 1-day female    32 head, mated 4-day female    51 head, mated 20-day female    32 head, mated 1-day male    41 head, mated 4-day male    46 head, mated 20-day male    52 salivary gland, larvae L3 wandering    12 salivary gland, white prepupae    33 digestive system, larvae L3 wandering    57 digestive system, 1-day adult    42 digestive system, 4-day adult    73 digestive system, 20-day adult    53 fat body, larvae L3 wandering    20 fat body, white prepupae    48 fat body, pupae P8    54 carcass, larvae L3 wandering  (110) carcass, 1-day adult    46 carcass, 4-day adult    63 carcass, 20-day adult    51 ovary, virgin 4-day female  (186) ovary, mated 4-day female  (168) testis, mated 4-day male    98 accessory gland, mated 4-day male    35 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    121 central nervous system, larvae L3    122 central nervous system, pupae P8    76 head, virgin 1-day female    37 head, virgin 4-day female    34 head, virgin 20-day female    30 head, mated 1-day female    32 head, mated 4-day female    51 head, mated 20-day female    32 head, mated 1-day male    41 head, mated 4-day male    46 head, mated 20-day male    52 salivary gland, larvae L3 wandering    12 salivary gland, white prepupae    33 digestive system, larvae L3 wandering    57 digestive system, 1-day adult    42 digestive system, 4-day adult    73 digestive system, 20-day adult    53 fat body, larvae L3 wandering    20 fat body, white prepupae    48 fat body, pupae P8    54 carcass, larvae L3 wandering    110 carcass, 1-day adult    46 carcass, 4-day adult    63 carcass, 20-day adult    51 ovary, virgin 4-day female    186 ovary, mated 4-day female    168 testis, mated 4-day male    98 accessory gland, mated 4-day male    35 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    121 central nervous system, larvae L3    122 central nervous system, pupae P8    76 head, virgin 1-day female    37 head, virgin 4-day female    34 head, virgin 20-day female    30 head, mated 1-day female    32 head, mated 4-day female    51 head, mated 20-day female    32 head, mated 1-day male    41 head, mated 4-day male    46 head, mated 20-day male    52 salivary gland, larvae L3 wandering    12 salivary gland, white prepupae    33 digestive system, larvae L3 wandering    57 digestive system, 1-day adult    42 digestive system, 4-day adult    73 digestive system, 20-day adult    53 fat body, larvae L3 wandering    20 fat body, white prepupae    48 fat body, pupae P8    54 carcass, larvae L3 wandering    110 carcass, 1-day adult    46 carcass, 4-day adult    63 carcass, 20-day adult    51 ovary, virgin 4-day female    186 ovary, mated 4-day female    168 testis, mated 4-day male    98 accessory gland, mated 4-day male    35 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (121) central nervous system, larvae L3  (122) central nervous system, pupae P8  (76) head, virgin 1-day female  (37) head, virgin 4-day female  (34) head, virgin 20-day female  30 head, mated 1-day female  32 head, mated 4-day female  (51) head, mated 20-day female  32 head, mated 1-day male  (41) head, mated 4-day male  (46) head, mated 20-day male  (52) salivary gland, larvae L3 wandering    12 salivary gland, white prepupae  (33) digestive system, larvae L3 wandering  (57) digestive system, 1-day adult  (42) digestive system, 4-day adult  (73) digestive system, 20-day adult  (53) fat body, larvae L3 wandering    20 fat body, white prepupae  (48) fat body, pupae P8  (54) carcass, larvae L3 wandering  (110) carcass, 1-day adult  (46) carcass, 4-day adult  (63) carcass, 20-day adult  (51) ovary, virgin 4-day female  (186) ovary, mated 4-day female  (168) testis, mated 4-day male  (98) accessory gland, mated 4-day male  (35) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  121 central nervous system, larvae L3  122 central nervous system, pupae P8    76 head, virgin 1-day female    37 head, virgin 4-day female    34 head, virgin 20-day female    30 head, mated 1-day female    32 head, mated 4-day female    51 head, mated 20-day female    32 head, mated 1-day male    41 head, mated 4-day male    46 head, mated 20-day male    52 salivary gland, larvae L3 wandering    12 salivary gland, white prepupae    33 digestive system, larvae L3 wandering    57 digestive system, 1-day adult    42 digestive system, 4-day adult    73 digestive system, 20-day adult    53 fat body, larvae L3 wandering    20 fat body, white prepupae    48 fat body, pupae P8    54 carcass, larvae L3 wandering  110 carcass, 1-day adult    46 carcass, 4-day adult    63 carcass, 20-day adult    51 ovary, virgin 4-day female  (186) ovary, mated 4-day female  (168) testis, mated 4-day male    98 accessory gland, mated 4-day male    35 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    121 central nervous system, larvae L3    122 central nervous system, pupae P8    76 head, virgin 1-day female    37 head, virgin 4-day female    34 head, virgin 20-day female    30 head, mated 1-day female    32 head, mated 4-day female    51 head, mated 20-day female    32 head, mated 1-day male    41 head, mated 4-day male    46 head, mated 20-day male    52 salivary gland, larvae L3 wandering    12 salivary gland, white prepupae    33 digestive system, larvae L3 wandering    57 digestive system, 1-day adult    42 digestive system, 4-day adult    73 digestive system, 20-day adult    53 fat body, larvae L3 wandering    20 fat body, white prepupae    48 fat body, pupae P8    54 carcass, larvae L3 wandering    110 carcass, 1-day adult    46 carcass, 4-day adult    63 carcass, 20-day adult    51 ovary, virgin 4-day female    186 ovary, mated 4-day female    168 testis, mated 4-day male    98 accessory gland, mated 4-day male    35 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 00-06 hour embryonic stages, during early larval stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    161 embryo 02-04hr    38 embryo 04-06hr    60 embryo 06-08hr    110 embryo 08-10hr    100 embryo 10-12hr    90 embryo 12-14hr    69 embryo 14-16hr    60 embryo 16-18hr    47 embryo 18-20hr    46 embryo 20-22hr    65 embryo 22-24hr    63 larva L1    143 larva L2    122 larva L3 12hr old    79 larva L3 puffstage 1-2    43 larva L3 puffstage 3-6    73 larva L3 puffstage 7-9    82 white prepupae new    77 white prepupae 12hr    80 white prepupae 24hr    84 pupae 2d postWPP    70 pupae 3d postWPP    56 pupae 4d postWPP    54 adult male 01day    53 adult male 05day    64 adult male 30day    59 adult female 01day    96 adult female 05day    137 adult female 30day    129 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (161) embryo 02-04hr  (38) embryo 04-06hr  (60) embryo 06-08hr  (110) embryo 08-10hr  (100) embryo 10-12hr  (90) embryo 12-14hr  (69) embryo 14-16hr  (60) embryo 16-18hr  (47) embryo 18-20hr  (46) embryo 20-22hr  (65) embryo 22-24hr  (63) larva L1  (143) larva L2  (122) larva L3 12hr old  (79) larva L3 puffstage 1-2  (43) larva L3 puffstage 3-6  (73) larva L3 puffstage 7-9  (82) white prepupae new  (77) white prepupae 12hr  (80) white prepupae 24hr  (84) pupae 2d postWPP  (70) pupae 3d postWPP  (56) pupae 4d postWPP  (54) adult male 01day  (53) adult male 05day  (64) adult male 30day  (59) adult female 01day  (96) adult female 05day  (137) adult female 30day  (129) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (161) embryo 02-04hr    38 embryo 04-06hr    60 embryo 06-08hr  (110) embryo 08-10hr    100 embryo 10-12hr    90 embryo 12-14hr    69 embryo 14-16hr    60 embryo 16-18hr    47 embryo 18-20hr    46 embryo 20-22hr    65 embryo 22-24hr    63 larva L1  (143) larva L2  (122) larva L3 12hr old    79 larva L3 puffstage 1-2    43 larva L3 puffstage 3-6    73 larva L3 puffstage 7-9    82 white prepupae new    77 white prepupae 12hr    80 white prepupae 24hr    84 pupae 2d postWPP    70 pupae 3d postWPP    56 pupae 4d postWPP    54 adult male 01day    53 adult male 05day    64 adult male 30day    59 adult female 01day    96 adult female 05day  (137) adult female 30day  (129) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    161 embryo 02-04hr    38 embryo 04-06hr    60 embryo 06-08hr    110 embryo 08-10hr    100 embryo 10-12hr    90 embryo 12-14hr    69 embryo 14-16hr    60 embryo 16-18hr    47 embryo 18-20hr    46 embryo 20-22hr    65 embryo 22-24hr    63 larva L1    143 larva L2    122 larva L3 12hr old    79 larva L3 puffstage 1-2    43 larva L3 puffstage 3-6    73 larva L3 puffstage 7-9    82 white prepupae new    77 white prepupae 12hr    80 white prepupae 24hr    84 pupae 2d postWPP    70 pupae 3d postWPP    56 pupae 4d postWPP    54 adult male 01day    53 adult male 05day    64 adult male 30day    59 adult female 01day    96 adult female 05day    137 adult female 30day    129 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    161 embryo 02-04hr    38 embryo 04-06hr    60 embryo 06-08hr    110 embryo 08-10hr    100 embryo 10-12hr    90 embryo 12-14hr    69 embryo 14-16hr    60 embryo 16-18hr    47 embryo 18-20hr    46 embryo 20-22hr    65 embryo 22-24hr    63 larva L1    143 larva L2    122 larva L3 12hr old    79 larva L3 puffstage 1-2    43 larva L3 puffstage 3-6    73 larva L3 puffstage 7-9    82 white prepupae new    77 white prepupae 12hr    80 white prepupae 24hr    84 pupae 2d postWPP    70 pupae 3d postWPP    56 pupae 4d postWPP    54 adult male 01day    53 adult male 05day    64 adult male 30day    59 adult female 01day    96 adult female 05day    137 adult female 30day    129 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (161) embryo 02-04hr  (38) embryo 04-06hr  (60) embryo 06-08hr  (110) embryo 08-10hr  (100) embryo 10-12hr  (90) embryo 12-14hr  (69) embryo 14-16hr  (60) embryo 16-18hr  (47) embryo 18-20hr  (46) embryo 20-22hr  (65) embryo 22-24hr  (63) larva L1  (143) larva L2  (122) larva L3 12hr old  (79) larva L3 puffstage 1-2  (43) larva L3 puffstage 3-6  (73) larva L3 puffstage 7-9  (82) white prepupae new  (77) white prepupae 12hr  (80) white prepupae 24hr  (84) pupae 2d postWPP  (70) pupae 3d postWPP  (56) pupae 4d postWPP  (54) adult male 01day  (53) adult male 05day  (64) adult male 30day  (59) adult female 01day  (96) adult female 05day  (137) adult female 30day  (129) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (161) embryo 02-04hr    38 embryo 04-06hr    60 embryo 06-08hr  110 embryo 08-10hr    100 embryo 10-12hr    90 embryo 12-14hr    69 embryo 14-16hr    60 embryo 16-18hr    47 embryo 18-20hr    46 embryo 20-22hr    65 embryo 22-24hr    63 larva L1  143 larva L2  122 larva L3 12hr old    79 larva L3 puffstage 1-2    43 larva L3 puffstage 3-6    73 larva L3 puffstage 7-9    82 white prepupae new    77 white prepupae 12hr    80 white prepupae 24hr    84 pupae 2d postWPP    70 pupae 3d postWPP    56 pupae 4d postWPP    54 adult male 01day    53 adult male 05day    64 adult male 30day    59 adult female 01day    96 adult female 05day  137 adult female 30day  129 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    161 embryo 02-04hr    38 embryo 04-06hr    60 embryo 06-08hr    110 embryo 08-10hr    100 embryo 10-12hr    90 embryo 12-14hr    69 embryo 14-16hr    60 embryo 16-18hr    47 embryo 18-20hr    46 embryo 20-22hr    65 embryo 22-24hr    63 larva L1    143 larva L2    122 larva L3 12hr old    79 larva L3 puffstage 1-2    43 larva L3 puffstage 3-6    73 larva L3 puffstage 7-9    82 white prepupae new    77 white prepupae 12hr    80 white prepupae 24hr    84 pupae 2d postWPP    70 pupae 3d postWPP    56 pupae 4d postWPP    54 adult male 01day    53 adult male 05day    64 adult male 30day    59 adult female 01day    96 adult female 05day    137 adult female 30day    129 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    127 Schneider line 2 Sg4    168 embryonic 1182-4H    105 embryonic GM2    105 embryonic Kc167    67 embryonic S1    183 embryonic S3    153 leg disc CME L1    154 wing disc CME-W2    100 wing disc ML-DmD8    95 wing disc ML-DmD9    105 wing disc ML-DmD16-c3    118 wing disc ML-DmD21    84 wing disc ML-DmD32    60 haltere disc ML-DmD17-c3    182 eye-antennal disc ML-DmD11    102 antennal disc ML-DmD20-c5    127 mixed discs ML-DmD4-c1    147 CNS ML-DmBG1-c1    119 CNS ML-DmBG2-c2    86 tumorous blood cells mbn2    122 ovary fGS/OSS    129 ovary OSC    134 ovary OSS    84 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (127) Schneider line 2 Sg4  (168) embryonic 1182-4H  (105) embryonic GM2  (105) embryonic Kc167  (67) embryonic S1  (183) embryonic S3  (153) leg disc CME L1  (154) wing disc CME-W2  (100) wing disc ML-DmD8  (95) wing disc ML-DmD9  (105) wing disc ML-DmD16-c3  (118) wing disc ML-DmD21  (84) wing disc ML-DmD32  (60) haltere disc ML-DmD17-c3  (182) eye-antennal disc ML-DmD11  (102) antennal disc ML-DmD20-c5  (127) mixed discs ML-DmD4-c1  (147) CNS ML-DmBG1-c1  (119) CNS ML-DmBG2-c2  (86) tumorous blood cells mbn2  (122) ovary fGS/OSS  (129) ovary OSC  (134) ovary OSS  (84) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (127) Schneider line 2 Sg4  (168) embryonic 1182-4H  105 embryonic GM2  105 embryonic Kc167    67 embryonic S1  (183) embryonic S3  (153) leg disc CME L1  (154) wing disc CME-W2    100 wing disc ML-DmD8    95 wing disc ML-DmD9  105 wing disc ML-DmD16-c3  (118) wing disc ML-DmD21    84 wing disc ML-DmD32    60 haltere disc ML-DmD17-c3  (182) eye-antennal disc ML-DmD11  102 antennal disc ML-DmD20-c5  (127) mixed discs ML-DmD4-c1  (147) CNS ML-DmBG1-c1  (119) CNS ML-DmBG2-c2    86 tumorous blood cells mbn2  (122) ovary fGS/OSS  (129) ovary OSC  (134) ovary OSS    84 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    127 Schneider line 2 Sg4    168 embryonic 1182-4H    105 embryonic GM2    105 embryonic Kc167    67 embryonic S1    183 embryonic S3    153 leg disc CME L1    154 wing disc CME-W2    100 wing disc ML-DmD8    95 wing disc ML-DmD9    105 wing disc ML-DmD16-c3    118 wing disc ML-DmD21    84 wing disc ML-DmD32    60 haltere disc ML-DmD17-c3    182 eye-antennal disc ML-DmD11    102 antennal disc ML-DmD20-c5    127 mixed discs ML-DmD4-c1    147 CNS ML-DmBG1-c1    119 CNS ML-DmBG2-c2    86 tumorous blood cells mbn2    122 ovary fGS/OSS    129 ovary OSC    134 ovary OSS    84 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    127 Schneider line 2 Sg4    168 embryonic 1182-4H    105 embryonic GM2    105 embryonic Kc167    67 embryonic S1    183 embryonic S3    153 leg disc CME L1    154 wing disc CME-W2    100 wing disc ML-DmD8    95 wing disc ML-DmD9    105 wing disc ML-DmD16-c3    118 wing disc ML-DmD21    84 wing disc ML-DmD32    60 haltere disc ML-DmD17-c3    182 eye-antennal disc ML-DmD11    102 antennal disc ML-DmD20-c5    127 mixed discs ML-DmD4-c1    147 CNS ML-DmBG1-c1    119 CNS ML-DmBG2-c2    86 tumorous blood cells mbn2    122 ovary fGS/OSS    129 ovary OSC    134 ovary OSS    84 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (127) Schneider line 2 Sg4  (168) embryonic 1182-4H  (105) embryonic GM2  (105) embryonic Kc167  (67) embryonic S1  (183) embryonic S3  (153) leg disc CME L1  (154) wing disc CME-W2  (100) wing disc ML-DmD8  (95) wing disc ML-DmD9  (105) wing disc ML-DmD16-c3  (118) wing disc ML-DmD21  (84) wing disc ML-DmD32  (60) haltere disc ML-DmD17-c3  (182) eye-antennal disc ML-DmD11  (102) antennal disc ML-DmD20-c5  (127) mixed discs ML-DmD4-c1  (147) CNS ML-DmBG1-c1  (119) CNS ML-DmBG2-c2  (86) tumorous blood cells mbn2  (122) ovary fGS/OSS  (129) ovary OSC  (134) ovary OSS  (84) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  127 Schneider line 2 Sg4  (168) embryonic 1182-4H  105 embryonic GM2  105 embryonic Kc167    67 embryonic S1  (183) embryonic S3  (153) leg disc CME L1  (154) wing disc CME-W2    100 wing disc ML-DmD8    95 wing disc ML-DmD9  105 wing disc ML-DmD16-c3  118 wing disc ML-DmD21    84 wing disc ML-DmD32    60 haltere disc ML-DmD17-c3  (182) eye-antennal disc ML-DmD11  102 antennal disc ML-DmD20-c5  127 mixed discs ML-DmD4-c1  (147) CNS ML-DmBG1-c1  119 CNS ML-DmBG2-c2    86 tumorous blood cells mbn2  122 ovary fGS/OSS  129 ovary OSC  134 ovary OSS    84 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    127 Schneider line 2 Sg4    168 embryonic 1182-4H    105 embryonic GM2    105 embryonic Kc167    67 embryonic S1    183 embryonic S3    153 leg disc CME L1    154 wing disc CME-W2    100 wing disc ML-DmD8    95 wing disc ML-DmD9    105 wing disc ML-DmD16-c3    118 wing disc ML-DmD21    84 wing disc ML-DmD32    60 haltere disc ML-DmD17-c3    182 eye-antennal disc ML-DmD11    102 antennal disc ML-DmD20-c5    127 mixed discs ML-DmD4-c1    147 CNS ML-DmBG1-c1    119 CNS ML-DmBG2-c2    86 tumorous blood cells mbn2    122 ovary fGS/OSS    129 ovary OSC    134 ovary OSS    84 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    59 cold shock, 4-day adult    40 heat shock, 4-day adult    125 Cadmium 50 mM 6 hrs, larvae L3    45 Cadmium 50 mM 12 hrs, larvae L3    46 Cadmium 50 mM 48 hrs, 4-day adult    81 Cadmium 100 mM 48 hrs, 4-day adult    135 Copper 0.5 mM 12 hrs, larvae L3    46 Copper 15 mM 48 hrs, 4-day adult    180 Zinc 5 mM 12 hrs, larvae L3    37 Zinc 4.5 mM 48 hrs, 4-day adult    66 Ethanol 2.5% 3 hrs, larvae L3    150 Ethanol 5% 3 hrs, larvae L3    39 Ethanol 10% 3 hrs, larvae L3    52 Caffeine 1.5 mg/ml 4 hrs, larvae L3    25 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    111 Caffeine 25 mg/ml 48 hrs, 4-day adult    55 Paraquat 5 mM 48 hrs, 4-day adult    95 Paraquat 10 mM 48 hrs, 4-day adult    95 Rotenone 2 μg 12 hrs, larvae L3    53 Rotenone 8 μg 12 hrs, larvae L3    51 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (59) cold shock, 4-day adult  (40) heat shock, 4-day adult  (125) Cadmium 50 mM 6 hrs, larvae L3  (45) Cadmium 50 mM 12 hrs, larvae L3  (46) Cadmium 50 mM 48 hrs, 4-day adult  (81) Cadmium 100 mM 48 hrs, 4-day adult  (135) Copper 0.5 mM 12 hrs, larvae L3  (46) Copper 15 mM 48 hrs, 4-day adult  (180) Zinc 5 mM 12 hrs, larvae L3  (37) Zinc 4.5 mM 48 hrs, 4-day adult  (66) Ethanol 2.5% 3 hrs, larvae L3  (150) Ethanol 5% 3 hrs, larvae L3  (39) Ethanol 10% 3 hrs, larvae L3  (52) Caffeine 1.5 mg/ml 4 hrs, larvae L3    25 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (111) Caffeine 25 mg/ml 48 hrs, 4-day adult  (55) Paraquat 5 mM 48 hrs, 4-day adult  (95) Paraquat 10 mM 48 hrs, 4-day adult  (95) Rotenone 2 μg 12 hrs, larvae L3  (53) Rotenone 8 μg 12 hrs, larvae L3  (51) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    59 cold shock, 4-day adult    40 heat shock, 4-day adult  (125) Cadmium 50 mM 6 hrs, larvae L3    45 Cadmium 50 mM 12 hrs, larvae L3    46 Cadmium 50 mM 48 hrs, 4-day adult    81 Cadmium 100 mM 48 hrs, 4-day adult  (135) Copper 0.5 mM 12 hrs, larvae L3    46 Copper 15 mM 48 hrs, 4-day adult  (180) Zinc 5 mM 12 hrs, larvae L3    37 Zinc 4.5 mM 48 hrs, 4-day adult    66 Ethanol 2.5% 3 hrs, larvae L3  (150) Ethanol 5% 3 hrs, larvae L3    39 Ethanol 10% 3 hrs, larvae L3    52 Caffeine 1.5 mg/ml 4 hrs, larvae L3    25 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (111) Caffeine 25 mg/ml 48 hrs, 4-day adult    55 Paraquat 5 mM 48 hrs, 4-day adult    95 Paraquat 10 mM 48 hrs, 4-day adult    95 Rotenone 2 μg 12 hrs, larvae L3    53 Rotenone 8 μg 12 hrs, larvae L3    51 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    59 cold shock, 4-day adult    40 heat shock, 4-day adult    125 Cadmium 50 mM 6 hrs, larvae L3    45 Cadmium 50 mM 12 hrs, larvae L3    46 Cadmium 50 mM 48 hrs, 4-day adult    81 Cadmium 100 mM 48 hrs, 4-day adult    135 Copper 0.5 mM 12 hrs, larvae L3    46 Copper 15 mM 48 hrs, 4-day adult    180 Zinc 5 mM 12 hrs, larvae L3    37 Zinc 4.5 mM 48 hrs, 4-day adult    66 Ethanol 2.5% 3 hrs, larvae L3    150 Ethanol 5% 3 hrs, larvae L3    39 Ethanol 10% 3 hrs, larvae L3    52 Caffeine 1.5 mg/ml 4 hrs, larvae L3    25 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    111 Caffeine 25 mg/ml 48 hrs, 4-day adult    55 Paraquat 5 mM 48 hrs, 4-day adult    95 Paraquat 10 mM 48 hrs, 4-day adult    95 Rotenone 2 μg 12 hrs, larvae L3    53 Rotenone 8 μg 12 hrs, larvae L3    51 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    59 cold shock, 4-day adult    40 heat shock, 4-day adult    125 Cadmium 50 mM 6 hrs, larvae L3    45 Cadmium 50 mM 12 hrs, larvae L3    46 Cadmium 50 mM 48 hrs, 4-day adult    81 Cadmium 100 mM 48 hrs, 4-day adult    135 Copper 0.5 mM 12 hrs, larvae L3    46 Copper 15 mM 48 hrs, 4-day adult    180 Zinc 5 mM 12 hrs, larvae L3    37 Zinc 4.5 mM 48 hrs, 4-day adult    66 Ethanol 2.5% 3 hrs, larvae L3    150 Ethanol 5% 3 hrs, larvae L3    39 Ethanol 10% 3 hrs, larvae L3    52 Caffeine 1.5 mg/ml 4 hrs, larvae L3    25 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    111 Caffeine 25 mg/ml 48 hrs, 4-day adult    55 Paraquat 5 mM 48 hrs, 4-day adult    95 Paraquat 10 mM 48 hrs, 4-day adult    95 Rotenone 2 μg 12 hrs, larvae L3    53 Rotenone 8 μg 12 hrs, larvae L3    51 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (59) cold shock, 4-day adult  (40) heat shock, 4-day adult  (125) Cadmium 50 mM 6 hrs, larvae L3  (45) Cadmium 50 mM 12 hrs, larvae L3  (46) Cadmium 50 mM 48 hrs, 4-day adult  (81) Cadmium 100 mM 48 hrs, 4-day adult  (135) Copper 0.5 mM 12 hrs, larvae L3  (46) Copper 15 mM 48 hrs, 4-day adult  (180) Zinc 5 mM 12 hrs, larvae L3  (37) Zinc 4.5 mM 48 hrs, 4-day adult  (66) Ethanol 2.5% 3 hrs, larvae L3  (150) Ethanol 5% 3 hrs, larvae L3  (39) Ethanol 10% 3 hrs, larvae L3  (52) Caffeine 1.5 mg/ml 4 hrs, larvae L3    25 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (111) Caffeine 25 mg/ml 48 hrs, 4-day adult  (55) Paraquat 5 mM 48 hrs, 4-day adult  (95) Paraquat 10 mM 48 hrs, 4-day adult  (95) Rotenone 2 μg 12 hrs, larvae L3  (53) Rotenone 8 μg 12 hrs, larvae L3  (51) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    59 cold shock, 4-day adult    40 heat shock, 4-day adult  125 Cadmium 50 mM 6 hrs, larvae L3    45 Cadmium 50 mM 12 hrs, larvae L3    46 Cadmium 50 mM 48 hrs, 4-day adult    81 Cadmium 100 mM 48 hrs, 4-day adult  135 Copper 0.5 mM 12 hrs, larvae L3    46 Copper 15 mM 48 hrs, 4-day adult  (180) Zinc 5 mM 12 hrs, larvae L3    37 Zinc 4.5 mM 48 hrs, 4-day adult    66 Ethanol 2.5% 3 hrs, larvae L3  (150) Ethanol 5% 3 hrs, larvae L3    39 Ethanol 10% 3 hrs, larvae L3    52 Caffeine 1.5 mg/ml 4 hrs, larvae L3    25 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  111 Caffeine 25 mg/ml 48 hrs, 4-day adult    55 Paraquat 5 mM 48 hrs, 4-day adult    95 Paraquat 10 mM 48 hrs, 4-day adult    95 Rotenone 2 μg 12 hrs, larvae L3    53 Rotenone 8 μg 12 hrs, larvae L3    51 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    59 cold shock, 4-day adult    40 heat shock, 4-day adult    125 Cadmium 50 mM 6 hrs, larvae L3    45 Cadmium 50 mM 12 hrs, larvae L3    46 Cadmium 50 mM 48 hrs, 4-day adult    81 Cadmium 100 mM 48 hrs, 4-day adult    135 Copper 0.5 mM 12 hrs, larvae L3    46 Copper 15 mM 48 hrs, 4-day adult    180 Zinc 5 mM 12 hrs, larvae L3    37 Zinc 4.5 mM 48 hrs, 4-day adult    66 Ethanol 2.5% 3 hrs, larvae L3    150 Ethanol 5% 3 hrs, larvae L3    39 Ethanol 10% 3 hrs, larvae L3    52 Caffeine 1.5 mg/ml 4 hrs, larvae L3    25 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    111 Caffeine 25 mg/ml 48 hrs, 4-day adult    55 Paraquat 5 mM 48 hrs, 4-day adult    95 Paraquat 10 mM 48 hrs, 4-day adult    95 Rotenone 2 μg 12 hrs, larvae L3    53 Rotenone 8 μg 12 hrs, larvae L3    51 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_03 mE1_20_mRNA_expression_cluster_02
External Data & Images
Linkouts	BDGP expression data • LD32979 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0026418 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6603-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal Hsc70CbCB02656 lethal, with Scer\GAL429BD Hsc70CbGS3087 lethal, with Scer\GAL4c355 Hsc70CbGS3087 lethal, with Scer\GAL4hs.2sev Hsc70CbGS3087 lethal (with Df(3L)fz-GF3b) Hsc70CbS004112 Hsc70CbS031820 Hsc70CbS064906 Hsc70CbS132307a Hsc70CbS134217 Hsc70CbS134802 Hsc70CbS148513 lethal | embryonic stage | recessive Hsc70Cb1 Hsc70Cb00082 Hsc70CbS031820 Hsc70CbS064906 Hsc70CbS132307a Hsc70CbS134217 Hsc70CbS134802 Hsc70CbS148513 lethal | larval stage | recessive Hsc70CbS134802 lethal | pupal stage | recessive Hsc70Cb1 lethal | recessive Hsc70Cb00082 Hsc70Cb06704 Hsc70Cb07621 Hsc70CbS004112 Hsc70CbS031820 Hsc70CbS064906 Hsc70CbS134217 Hsc70CbS134802 Hsc70CbS148513 Hsc70CbYB0298 partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237 Hsc70CbGD11973 Other Phenotypes Allele visible, with Scer\GAL4dpp.blk1 Hsc70CbGS3087 visible, with Scer\GAL4pnr-MD237 Hsc70CbGD11973 Phenotype manifest in Allele arista, with Scer\GAL4dpp.blk1 Hsc70CbGS3087 mesothoracic tergum, with Scer\GAL4pnr-MD237 Hsc70CbGD11973 trichogen cell, with Scer\GAL4pnr-MD237 Hsc70CbGD11973
Classical Alleles ( 27 )
For All Classical Alleles Show
Allele of Hsc70Cb Class Mutagen Stocks Known lesion Hsc70CbEY00671 2 -- Hsc70Cb00082 P-element activity X ray 1 Yes Hsc70Cb5-HA-2768 1 -- Hsc70Cb5-SZ-3315 1 -- Hsc70Cb5-SZ-3951 1 -- Hsc70Cbc04771 piggyBac transposase 1 -- Hsc70CbCB-5489-3 1 -- Hsc70Cbd03562 P-element activity 1 -- Hsc70Cbd06126 P-element activity 1 -- Hsc70CbKG03227a P-element activity 1 -- Hsc70CbUM-8096-3 1 -- Hsc70Cb06704 P-element activity 0 -- Hsc70Cb07621 P-element activity 0 Yes Hsc70Cb1 X ray 0 -- Hsc70CbCB02656 P-element activity 0 Yes Hsc70CbCPTI002201 piggyBac transposase 0 Yes Hsc70CbCPTI002804 piggyBac transposase 0 Yes Hsc70Cbd07917 P-element activity 0 -- Hsc70CbGS3087 Delta2-3 0 Yes Hsc70CbS004112 Delta2-3 P-element activity 0 -- Hsc70CbS031820 Delta2-3 P-element activity 0 -- Hsc70CbS064906 Delta2-3 0 -- Hsc70CbS132307a Delta2-3 0 -- Hsc70CbS134217 Delta2-3 P-element activity 0 Yes Hsc70CbS134802 Delta2-3 P-element activity 0 -- Hsc70CbS148513 Delta2-3 P-element activity 0 -- Hsc70CbYB0298 Delta2-3 0 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Hsc70Cb Class Mutagen Stocks Known lesion Hsc70CbGD11973 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Hsc70CbHMS01080 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Hsc70CbNIG.6603R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)D-1rv16 (Burmester et al., 2000, Carpenter, 1994) Df(3L)D-5rv6 (Burmester et al., 2000, Carpenter, 1994) Df(3L)fz-CAL5 (Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(3L)fz-GF3b (Szeged Stock Center, 1998-, Spradling et al., 1999, Burmester et al., 2000, BDGP Project Members, 1994-1999, Carpenter, 1994, Deak et al., 1997)
Not disrupted in	Df(3L)D-4rv34 (Carpenter, 1994) Df(3L)fz-D21 (Burmester et al., 2000, BDGP Project Members, 1994-1999, Carpenter, 1994) Df(3L)fz-GS1a (Spradling et al., 1999, Burmester et al., 2000, BDGP Project Members, 1994-1999, Carpenter, 1994) Df(3L)fz-M21 (Spradling et al., 1999, Burmester et al., 2000, BDGP Project Members, 1994-1999, Carpenter, 1994) Df(3L)J40 (Burmester et al., 2000)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11973} NA P{NIG.6603R} NA P{TRiP.HMS01080} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}Hsc70CbS004112 No P{lacW}Hsc70CbS031820 No P{lacW}Hsc70CbS064906 No P{lacW}Hsc70CbS134217 No P{lacW}Hsc70CbS134802 No P{lacW}Hsc70CbS148513 No P{PZ}Hsc70Cb00082 No P{PZ}Hsc70Cb06704 No P{PZ}Hsc70Cb07621 No miscellaneous insertions P{PTT-GB}Hsc70CbCB02656 NA P{PTT-GB}Hsc70CbYB0298 NA P{RS3}Hsc70CbCB-5489-3 NA P{RS3}Hsc70CbUM-8096-3 NA P{RS5}Hsc70Cb5-HA-2768 NA P{RS5}Hsc70Cb5-SZ-3315 NA P{RS5}Hsc70Cb5-SZ-3951 NA P{SUPor-P}Hsc70CbKG03227a NA PBac{754.P.FSVS-0}Hsc70CbCPTI002201 NA PBac{754.P.FSVS-0}Hsc70CbCPTI002804 NA PBac{PB}Hsc70Cbc04771 NA insertion of mobile activating element P{EPgy2}Hsc70CbEY00671 NA P{GSV1}1774 NA P{GSV1}Hsc70CbGS3087 NA P{XP}Hsc70Cbd03562 NA P{XP}Hsc70Cbd06126 NA P{XP}Hsc70Cbd07917 NA
Gene Ontology: Function, Process & Cellular Component ( 2 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
chaperone binding inferred from sequence or structural similarity with Saccharomyces SSE1 (FlyBase, 1992-)
Biological Process
CV term Evidence References
protein folding inferred from sequence or structural similarity with Saccharomyces SSE1 (FlyBase, 1992-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Hsc70Cb - Akap200 experimental knowledge based (Guruharsha et al., 2011) Hsc70Cb - AnxB10 experimental knowledge based (Guruharsha et al., 2011) Hsc70Cb - CG10425 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hsc70Cb - CG10638 experimental knowledge based (Guruharsha et al., 2011) Hsc70Cb - CG11191 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hsc70Cb - CG13539 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hsc70Cb - CG14715 experimental knowledge based (Guruharsha et al., 2011) Hsc70Cb - CG14762 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hsc70Cb - CG17337 experimental knowledge based (Guruharsha et al., 2011) Hsc70Cb - CG18335 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hsc70Cb - CG2862 experimental knowledge based (Guruharsha et al., 2011) Hsc70Cb - CG5044 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hsc70Cb - CG5380 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hsc70Cb - CG5577 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hsc70Cb - CG6674 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hsc70Cb - CG8036 experimental knowledge based (Guruharsha et al., 2011) Hsc70Cb - CSN4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hsc70Cb - Chd64 experimental knowledge based (Guruharsha et al., 2011) Hsc70Cb - Crc experimental knowledge based (Guruharsha et al., 2011) Hsc70Cb - D1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hsc70Cb - Df31 experimental knowledge based (Guruharsha et al., 2011) Hsc70Cb - EndoGI experimental knowledge based (Guruharsha et al., 2011) Hsc70Cb - Eno experimental knowledge based (Guruharsha et al., 2011) Hsc70Cb - Fkbp13 experimental knowledge based (Guruharsha et al., 2011) Hsc70Cb - Gdi experimental knowledge based (Guruharsha et al., 2011) Hsc70Cb - Hop experimental knowledge based (Guruharsha et al., 2011) Hsc70Cb - Hsp70Bb anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hsc70Cb - Inos experimental knowledge based (Guruharsha et al., 2011) Hsc70Cb - Mip anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hsc70Cb - Moe experimental knowledge based (Guruharsha et al., 2011) Hsc70Cb - Mst85C anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hsc70Cb - Nacα experimental knowledge based (Guruharsha et al., 2011) Hsc70Cb - Oat anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hsc70Cb - PP2A-B' anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hsc70Cb - Proct anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hsc70Cb - Prx2540-2 experimental knowledge based (Guruharsha et al., 2011) Hsc70Cb - RpS21 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hsc70Cb - Sh3β experimental knowledge based (Guruharsha et al., 2011) Hsc70Cb - TER94 experimental knowledge based (Guruharsha et al., 2011) Hsc70Cb - aur anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hsc70Cb - awd experimental knowledge based (Guruharsha et al., 2011) Hsc70Cb - cib experimental knowledge based (Guruharsha et al., 2011) Hsc70Cb - flr experimental knowledge based (Guruharsha et al., 2011) Hsc70Cb - fzr2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hsc70Cb - kdn experimental knowledge based (Guruharsha et al., 2011) Hsc70Cb - regucalcin experimental knowledge based (Guruharsha et al., 2011) Hsc70Cb - yip2 experimental knowledge based (Guruharsha et al., 2011)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Hsc70Cb allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0026418 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39557
Orthologs
OrthoDB Orthologs (54) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG69ZZ7N Dipteran inclusive ortholog search EOG60CHR1 Insect inclusive ortholog search EOG6NK9QJ Arthropod inclusive ortholog search EOG61VHHW Metazoa inclusive ortholog search EOG6W9WWP
Orthologs in Drosophila Species (EOG69ZZ7N)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Hsc70Cb     Drosophila simulans   Dsim\GD14475 Y   Drosophila sechellia   Dsec\GM25449 Y   Drosophila erecta   Dere\GG15669 Y   Drosophila yakuba   Dyak\GE21998 Y   Drosophila ananassae   Dana\GF24591 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA19716 Y   Drosophila persimilis   Dper\GL25289 Y   Drosophila willistoni   Dwil\GK17034 Y   Drosophila virilis   Dvir\GJ13748 Y   Drosophila mojavensis   Dmoj\GI13757 Y   Drosophila grimshawi   Dgri\GH15106 Y
Orthologs in non-Drosophila Dipterans (EOG60CHR1)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL017315   Anopheles gambiae Malaria mosquito  Agam\AGAP010331   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ019868
Orthologs in non-Dipteran Insects (EOG6NK9QJ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB50730   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG008765   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH23190   Atta cephalotes Leafcutter ant  Acep\ACEP21726   Camponotus floridanus Florida carpenter ant  Cflo\CFLO17185   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL13702   Linepithema humile Argentine ant  Lhum\LH25035   Pogonomyrmex barbatus Red harvester ant  Pbar\PB21958   Solenopsis invicta Red fire ant  Sinv\SINV17895   Acyrthosiphon pisum Pea aphid  Apim\ACYPI004698   Acyrthosiphon pisum Pea aphid  Apim\ACYPI004544   Bombyx mori Silkmoth  Bmor\BGIBMGA001218   Pediculus humanus Human body louse  Phum\PHUM507200   Tribolium castaneum Red flour beetle  Tcas\GLEAN_07971
Orthologs in non-Insect Arthropods (EOG61VHHW)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_229110   Daphnia pulex Water flea  Dpux\JGI_V11_53476   Daphnia pulex Water flea  Dpux\JGI_V11_53625   Ixodes scapularis Deer tick  Isca\ISCW024057   Ixodes scapularis Deer tick  Isca\ISCW016090
Orthologs in non-Arthropod Metazoa (EOG6W9WWP)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\C30C11.4   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_002779gn   Danio rerio Zebrafish  Drer\wu:fc07b10   Danio rerio Zebrafish  Drer\AL929092.1   Danio rerio Zebrafish  Drer\hspa4   Danio rerio Zebrafish  Drer\hspa4l   Xenopus tropicalis Western clawed frog  Xtro\hspa4   Xenopus tropicalis Western clawed frog  Xtro\hsph1   Gallus gallus Domestic chicken  Ggal\HSPA4   Gallus gallus Domestic chicken  Ggal\HSPH1   Gallus gallus Domestic chicken  Ggal\HSPA4L   Mus musculus House mouse  Mmus\Hspa4   Mus musculus House mouse  Mmus\Hspa4l   Mus musculus House mouse  Mmus\Hsph1   Rattus norvegicus Norway rat  Rnor\Hsph1   Rattus norvegicus Norway rat  Rnor\Hspa4l   Rattus norvegicus Norway rat  Rnor\Hspa4   Homo sapiens Human  Hsap\HSPA4L   Homo sapiens Human  Hsap\HSPH1   Homo sapiens Human  Hsap\HSPA4
Human Orthologs (3)
Gene OMIM HGNC Hsap\HSPA4L     Hsap\HSPH1     Hsap\HSPA4
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD14475 Drosophila sechellia Dsec\GM25449 Drosophila erecta Dere\GG15669 Drosophila yakuba Dyak\GE21998 Drosophila ananassae Dana\GF24591 Drosophila pseudoobscura pseudoobscura Dpse\GA19716 Drosophila persimilis Dper\GL25289 Drosophila willistoni Dwil\GK17034 Drosophila virilis Dvir\GJ13748 Drosophila mojavensis Dmoj\GI13757 Drosophila grimshawi Dgri\GH15106
Stocks & Reagents
Stocks Listed in FlyBase ( 15 )
Bloomington	33742 y1 sc* v1; P{TRiP.HMS01080}attP2 11485 P{PZ}Hsc70Cb00082 ry506/TM3, ryRK Sb1 Ser1
Harvard	- P{XP}Hsc70Cbd03562 - P{XP}Hsc70Cbd06126 - PBac{PB}Hsc70Cbc04771
Kyoto	123656 w1118; P{RS3}Hsc70CbCB-5489-3 124338 w1118; P{RS3}Hsc70CbUM-8096-3 125662 w1118; P{RS5}Hsc70Cb5-HA-2768 125991 w1118; P{RS5}Hsc70Cb5-SZ-3315 126248 w1118; P{RS5}Hsc70Cb5-SZ-3951
VDRC	v27680 w1118; P{GD11973}v27680 v27681 w1118; P{GD11973}v27681/CyO
	More stocks available...
Genomic Clones ( 1 )
	BACR35M01 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 140 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD32979
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT04147 AT16829 AT27136 AT28763 AT28924 GH01807 GH02028 GH02128 GH08741 GH11225 GH12450 GH24004 GH25571 GH26562 GH26584 GM01716 GM03212 GM05215 GM13939 GM17218 GM25637 HL02779 LD10211 LD10827 LD20342 LD32772 LD43019 LD46052 LP01204 LP01630 LP05594 LP06674 LP09125 LP09444 LP11886 LP13968 LP19408 LP22151 LP24193 RE04520 RE17573 RE28955 RE34345 RE35877 RE47386 RE58270 RE62021 RE66303 SD06616 SD06763 SD08619 SD19160 SD26371 SD27966
Other clones	39825 50578 52645 53272 76631 100452 146608 153301 214575.32 523076 534002 569917 bs18c08 bs22e04 CK01.91D.G7 CK01.128D.D11 Dmel_dig_017105_0684_2640 Dmel_neb_004607_0203_0422 Dmel_neb_011135_0128_1848 Dmel_neb_011346_0601_3480 Dmel_neb_014049_0664_2008 Dmel_neb_014737_0427_0732 EK062201 EK071828 EK168853 EK169946 EK206937 EK223110 EK249460 EK256655 EN03350 EN15859 EP11249 FGA002C11 FGC028H05 HL05504 RP003040397 RP003070726 RP003075079 RP003088687 RP003096084 RP003108233 RP003131103 RP003133370 RP003136064 RP003154285 RP003174542 RP003183498 RP003202872 RP003246768 RP003252945 RP003255618 RP003274854 RP003278243 RP003289631 RP003292167 RP003301018 RP003308604 RP003323376 RP003327046 RP003335712 RP003339215 RP003348345 RP003362366 RP003395976 RP003410921 RP003447984 RP003485817 RP003489312 RP003492472 RP003522402 RP003526700 RP003554569 RP003568529 RP003592245 RP003594638 RP003606227 RP003624340 RP003626722 RP003638842 RP003647563 RP003673004 UT01295 UT01906 UUGC0562
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0026418 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39557
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Hsc70Cb anon-WO0118547.302 (Burmester et al., 2000, FlyBase, 1996-) Source for merge of: Hsc70Cb BEST:LD32772 (Bayraktaroglu, 2000.11.2) Source for merge of: Hsc70Cb l(3)70Ca l(3)S148513 l(3)S134217 l(3)00082 (Maroy, 1999.4.20)
Additional comments	Source for merge of Hsc70Cb anon-WO0118547.302 was sequence comparison (date:051113). (Burmester et al., 2000, FlyBase, 1996-)
Other Comments
	dsRNA made from templates generated with primers directed against this gene results in a change in cell proliferation and cell size. (Guertin et al., 2006) Area matching Drosophila EST AI295731. This EST forms a 2018bp contig with ESTs AI258429, AA696170, AI109519 and AA391348, and has sequence similarity to Mouse APG-1 gene. (Davies, 2001.3.15)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_140430 NM_168573 NM_168574 NM_001202172 NM_001202173 NM_001202174 NM_001202175 NM_001274893 RefSeq (Proteins) • NP_648687 NP_729951 NP_729952 NP_001189101 NP_001189102 NP_001189103 NP_001189104 NP_001261822 DDBJ / EMBL / GenBank • AA951892 AA978811 AAF49766 AAF49767 AAL13861 AAN11823 ADV37537 ADV37538 ADV37539 ADV37540 AGB94515 AI062572 AI107499 AI134877 AI258429 AI295731 AI945915 AI946241 AJ132807 AJ132808 AJ132811 AJ132812 AJ132829 AQ026227 AW943157 AX094178 AY058632 BZ286270 CAA10789 CAB38172 CZ469503 CZ473426 CZ473427 CZ474933 CZ475991 G00462 Entrez Gene - A searchable database of RefSeq genes. • 39557 UniProtKB/TrEMBL • O96818 Q9VUC1 Q9XZT5
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Heat shock protein 70, conserved site (IPR018181) Heat shock protein 70 family (IPR013126) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD32979
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0026418 DRSC - Results from RNAi screens. • FBgn0026418 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0026418 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6603-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0026418 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39557 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39557 modMine - Data generated by the modENCODE project. • FBgn0026418
Synonyms & Secondary IDs ( 25 )
Reported As
Symbol Synonym	0041/12 (Deak et al., 1997) 0318/20 (Deak et al., 1997) 1342/17 (Deak et al., 1997) 1348/02 (Deak et al., 1997) 1485/13 (Deak et al., 1997) anon-WO0118547.302   BEST:LD32772   CG6603 (Quinones-Coello, 2007, Quinones-Coello, 2007, Rival et al., 2009, Monzo et al., 2010, Zhang et al., 2010, Ni et al., 2010.12.1, Cammarato et al., 2011) dHsp110 (Zhang et al., 2010) Hsc70 (Wellington and Zinsmaier, 2005, Tatar et al., 2003, Fredriksson et al., 2012) HSC-70 (Richmond and Broadie, 2002) HSC70 (Gunawardena et al., 2003, Folk et al., 2006) hsc70Cb (Burmester, 1999.3.1, Neal et al., 2006) Hsc70Cb (Guertin et al., 2006, Stuart et al., 2007, Buszczak et al., 2007, Quinones-Coello, 2007, Quinones-Coello, 2007, Kiss et al., 2005, Takemori and Yamamoto, 2009, Blard et al., 2007, Birch-Machin et al., 2005, Monzo et al., 2010, Beckstead et al., 2007, Franco et al., 2011, Japanese National Institute of Genetics, 2012.5.21) HSP110-1 (Nikolaidis and Nei, 2004) l(3)70Ca (Burmester et al., 2000, ) l(3)70Cb (Maroy, 1999.4.20, ) l(3)00082 (Spradling et al., 1999, ) l(3)07621 (Maroy, 1999.4.20, ) l(3)134217 (Mink, 1999.2.5) l(3)148513 (Mink, 1999.2.5) l(3)S134217   l(3)S134802   l(3)S148513   LD32772 (Toba et al., 1999)
Name Synonym	Hsc70Cb (Takemori and Yamamoto, 2009, Cammarato et al., 2011)
Secondary FlyBase IDs
	FBgn0010707 FBgn0010924 FBgn0013562 FBgn0026569 FBgn0027982 FBgn0028258 FBgn0028259 FBgn0062110
References ( 61 )
Generate a list of	All references relating to this gene ( 61 )
List References by type	Research paper  ( 21 ) Supplementary material  ( 7 ) Review  ( 2 ) Personal communication to FlyBase  ( 15 ) Abstract  ( 2 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 4 ) Stock list  ( 3 ) Patent  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 3 )
	Fredriksson et al., 2012, Aging Cell 11(4): 634--643 Effects of aging and reproduction on protein quality control in soma and gametes of Drosophila melanogaster. [FBrf0218923] Krauchunas et al., 2012, Dev. Biol. 370(1): 125--134 Protein phosphorylation changes reveal new candidates in the regulation of egg activation and early embryogenesis in D. melanogaster. [FBrf0219342] Franco et al., 2011, Mol. Cell. Proteomics 10(5): M110.002188 A Novel Strategy to Isolate Ubiquitin Conjugates Reveals Wide Role for Ubiquitination during Neural Development. [FBrf0213919] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...