FlyBase Gene Report: Dmel\HDAC6

General Information

Symbol

Dmel\HDAC6

Species

D. melanogaster

Name

Histone deacetylase 6

Annotation Symbol

CG6170

Feature Type

protein_coding_gene

FlyBase ID

FBgn0026428

Gene Model Status

Current

Stock Availability

16 publicly available

Gene Summary

Histone deacetylase 6 (HDAC6) encodes a cytosolic deacetylase that functions as a key modulator of proteostasis by mediating ubiquitin-proteasomal and lysosomal degradation of native and/or misfolded proteins. [Date last reviewed: 2018-09-27] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

dHDAC6, HDAC2, HDAC, dHDAC2

Key Links

Genomic Location

Cytogenetic map

13B6-13B6

Sequence location

X:15,333,310..15,340,360 [+]

Recombination map

1-50

RefSeq locus

NC_004354 REGION:15333310..15340360

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (14 terms)

Molecular Function (8 terms)

Terms Based on Experimental Evidence (7 terms)

CV Term

Evidence

References

enables deacetylase activity

inferred from mutant phenotype

(Miskiewicz et al., 2014)

enables histone deacetylase activity

inferred from direct assay

(Cho et al., 2005)

inferred from mutant phenotype

(Feller et al., 2015)

enables histone H4K12 deacetylase activity, hydrolytic mechanism

inferred from direct assay

(Barlow et al., 2001)

enables histone H4K16 deacetylase activity, hydrolytic mechanism

inferred from direct assay

(Barlow et al., 2001)

enables histone H4K5 deacetylase activity, hydrolytic mechanism

inferred from direct assay

(Barlow et al., 2001)

enables histone H4K8 deacetylase activity, hydrolytic mechanism

inferred from direct assay

(Barlow et al., 2001)

enables protein lysine deacetylase activity

inferred from direct assay

(Yan et al., 2017)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables histone deacetylase activity

inferred from biological aspect of ancestor with PANTHER:PTN008143312

(GO Reference Genome Project, 2011-)

non-traceable author statement

(Feller et al., 2015)

enables zinc ion binding

inferred from electronic annotation with InterPro:IPR001607

(InterPro Project Members, 2004-)

Biological Process (4 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

involved_in negative regulation of axon regeneration

inferred from mutant phenotype

(Vargas et al., 2020)

involved_in neurotransmitter secretion

inferred from mutant phenotype

(Miskiewicz et al., 2014)

involved_in regulation of DNA-templated transcription

inferred from direct assay

(Cho et al., 2005)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in epigenetic regulation of gene expression

inferred from biological aspect of ancestor with PANTHER:PTN008143312

(GO Reference Genome Project, 2011-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in cytoplasm

inferred from direct assay

(Cho et al., 2005)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

part_of histone deacetylase complex

inferred from biological aspect of ancestor with PANTHER:PTN000065904

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

RPD3/HDA1 LYSINE DEACETYLASES

Protein Family (UniProt)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

protein lysine deacetylase activity
RHEA 58108:

Summaries

Gene Snapshot

Gene Group (FlyBase)

RPD3/HDA1 LYSINE DEACETYLASES -: The RPD3/HDA1 family are Zn²⁺-dependent lysine deacetylases that share a common catalytic core domain. (Adapted from FBrf0159755).

Summary (Interactive Fly)

a microtubule-associated deacetylase - interacts with polyubiquitinated proteins to stimulate autophagy as a compensatory degradation system when the ubiquitin-proteasome system is impaired

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\HDAC6 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry M9PJN5)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Stop-codon suppression (UGA) postulated; FBrf0216884.

Gene model reviewed during 5.44

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.50

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

HDAC6-RA

FBtr0074008

NM_132789

4483

1128

HDAC6-RB

FBtr0074010

NM_167436

3848

1135

HDAC6-RC

FBtr0074009

NM_167437

4241

1138

HDAC6-RD

FBtr0301774

NM_001169289

3451

883

HDAC6-RE

FBtr0307383

NM_001258751

3817

1108

HDAC6-RF

FBtr0307384

NM_001258752

3272

1022

HDAC6-RG

FBtr0330405

NM_001272640

4483

1179

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

HDAC6-PA

FBpp0073825

124.9

1128

6.45

FBpp0073827

125.8

1135

6.45

FBpp0073826

126.0

1138

6.45

FBpp0290988

98.3

883

6.46

FBpp0298372

122.6

1108

6.32

FBpp0298373

113.3

1022

6.85

FBpp0303431

130.8

1179

6.50

M9PJN5

NP_001259569

AGB95411

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\HDAC6 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.65

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 13 -- 16

organism | faint | ubiquitous

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in cytoplasm

inferred from direct assay

(Cho et al., 2005)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\HDAC6 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\HDAC6

View exonic expression by tissue for Dmel\HDAC6

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0026428

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

32461/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0026428

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0026428

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0026428

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG6170

Flygut - An atlas of the Drosophila adult midgut

FBgn0026428

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 8 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 17 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of HDAC6

Transgenic constructs containing regulatory region of HDAC6

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 14 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^Tub.PU

HDAC6^RNAi.UAS.R16

viable

viable, with Scer\GAL4^Mef2.PR

HDAC6^RNAi.UAS.R16

Sterility

Allele

fertile

fertile, with Scer\GAL4^Mef2.PR

HDAC6^RNAi.UAS.R16

Other Phenotypes

Allele

abnormal locomotor behavior | adult stage | progressive

HDAC6^KO

abnormal neurophysiology

HDAC6^KO

abnormal neurophysiology, with Scer\GAL4^nSyb.PU

HDAC6^UAS.Tag:V5

abnormal touch perception

HDAC6^KO

abnormal touch perception (with Df(3L)BSC113)

HDAC6^KO

abnormal touch response | larval stage

HDAC6^KO

abnormal touch response | larval stage (with Df(3L)BSC113)

HDAC6^KO

decreased cell number | oogenesis, with Scer\GAL4^nanos.PU

HDAC6^JF01501

short lived | nutrition conditional

HDAC6^KO

visible | adult stage, with Scer\GAL4^en.PU

HDAC6^HMS00077

visible | adult stage | progressive, with Scer\GAL4^GMR.PU

HDAC6^RNAi.UAS

Phenotype manifest in

Allele

adult posterior midgut | progressive

HDAC6^KO

centriole

HDAC6^KO

cystoblast | decreased number, with Scer\GAL4^nanos.PU

HDAC6^JF01501

cytoplasmic microtubule | third instar larval stage

HDAC6^KO

cytoplasmic microtubule | third instar larval stage | conditional, with Scer\GAL4^C57

HDAC6^UAS.cDa

embryonic/larval neuromuscular junction | larval stage, with Scer\GAL4^RapGAP1-OK6

eye | adult stage | progressive, with Scer\GAL4^GMR.PU

HDAC6^RNAi.UAS

female germline stem cell | decreased number, with Scer\GAL4^nanos.PU

HDAC6^JF01501

indirect flight muscle cell | progressive

HDAC6^KO

larval somatic muscle cell | third instar larval stage

HDAC6^KO

larval somatic muscle cell | third instar larval stage | conditional, with Scer\GAL4^C57

HDAC6^UAS.cDa

lipid droplet | adult stage | progressive

HDAC6^KO

mesothoracic tergotrochanter muscle cell | progressive

HDAC6^KO

microtubule | larval stage, with Scer\GAL4^RapGAP1-OK6

spermatid axoneme | P-stage

HDAC6^KO

spermatozoon

HDAC6^KO

synapse

HDAC6^KO

synapse, with Scer\GAL4^Act.PU

HDAC6^UAS.Tag:V5

synaptic vesicle

HDAC6^KO

synaptic vesicle, with Scer\GAL4^Act.PU

HDAC6^UAS.Tag:V5

t-bar

HDAC6^KO

t-bar, with Scer\GAL4^Act.PU

HDAC6^UAS.Tag:V5

testis | progressive

HDAC6^KO

type Ib terminal bouton | larval stage, with Scer\GAL4^RapGAP1-OK6

wing disc | third instar larval stage

HDAC6^KO

wing vein, with Scer\GAL4^en.PU

HDAC6^HMS00077

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (20)

Hsap\HDAC6

14 of 14

Yes

Hsap\HDAC10

6 of 14

Yes

4 of 14

4 of 14

4 of 14

4 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Hsap\USP49

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (20)

Rnor\Hdac10

6 of 14

Yes

4 of 14

4 of 14

4 of 14

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Usp51

1 of 14

Mus musculus (laboratory mouse) (20)

Mmus\Hdac6

14 of 14

Yes

Mmus\Hdac10

6 of 14

Yes

4 of 14

4 of 14

4 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Usp51

1 of 14

Xenopus tropicalis (Western clawed frog) (14)

Xtro\hdac6

6 of 13

Yes

Xtro\hdac10

5 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\usp49

1 of 13

Danio rerio (Zebrafish) (20)

Drer\hdac6

14 of 14

Yes

Drer\hdac10

6 of 14

Yes

4 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Drer\usp49

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (14)

Cele\hda-6

13 of 14

Yes

Cele\hda-10

5 of 14

Yes

Cele\hda-5

4 of 14

Yes

Cele\hda-4

3 of 14

Cele\F43G6.17

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

Yes

Cele\F43G6.4

1 of 14

Cele\Y67D2.2

1 of 14

Anopheles gambiae (African malaria mosquito) (10)

Agam\AgaP_AGAP000532

11 of 12

Yes

3 of 12

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (18)

Atha\HDA05

9 of 13

Yes

Atha\HDA18

8 of 13

Yes

Atha\HDA15

7 of 13

Yes

Atha\HDA14

5 of 13

Yes

Atha\AT5G61050

4 of 13

Yes

Atha\HDA08

4 of 13

Yes

Atha\AT2G14825

2 of 13

Yes

Atha\AT4G09784

2 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

Yes

Atha\hda17

2 of 13

Yes

Atha\BRIZ1

1 of 13

Atha\BRIZ2

1 of 13

Atha\UBP22

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (8)

Scer\HDA1

9 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

Schizosaccharomyces pombe (Fission yeast) (6)

Spom\clr3

7 of 12

Yes

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:HDAC6. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (12)

6 of 13

4 of 13

4 of 13

4 of 13

1 of 13

not

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

age-dependent ectopic fat accumulation, HDAC6-related

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Allele

Disease

Evidence

References

HDAC6^KO

model of obesity

CEA

(Yan et al., 2017)

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

HDAC6; histone deacetylase 6

model of chondrodysplasia with platyspondyly, distinctive brachydactyly, hydrocephaly, and microphthalmia

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 9 )

Allele

Disease

Interaction

References

HDAC6^JF01501

ameliorates frontotemporal dementia and/or amyotrophic lateral sclerosis 2

modeled by Zzzz\GGGGCC^30.UAS.EGFP

(Kankel et al., 2020)

ameliorates autosomal dominant distal hereditary motor neuronopathy 3

modeled by Hsap\HSPB1^S135F.UAS

(Kang et al., 2020)

HDAC6^UAS.cDa

ameliorates Parkinson's disease

modeled by Hsap\SNCA^UAS.cFa

(Du et al., 2010)

ameliorates obesity

modeled by Lsd-2^UAS.EYFP

(Yan et al., 2017)

ameliorates Kufor-Rakeb syndrome

modeled by anne^HM05242

(Wang et al., 2019)

ameliorates Alzheimer's disease 1

modeled by Hsap\APP^{Aβ42.UAS.Tag:SS(rPENK)}

(Cheng et al., 2022)

HDAC6^KO

exacerbates Parkinson's disease

modeled by Hsap\SNCA^UAS.cFa

(Du et al., 2010)

ameliorates tauopathy

modeled by Hsap\MAPT^V337M.UAS

(Xiong et al., 2013)

modeled by Hsap\MAPT^UAS.cWa

(Xiong et al., 2013)

model of obesity

is ameliorated by Hsc70-4^UAS.cEa

(Yan et al., 2017)

is ameliorated by Lsd-2^HMS00629

(Yan et al., 2017)

is ameliorated by Lsd-2^KG00149

(Yan et al., 2017)

HDAC6^UAS.Tag:V5

ameliorates Kennedy's disease

modeled by Hsap\APP^{Aβ42.UAS.Tag:SS(nec)}

(Pandey et al., 2007)

modeled by Hsap\AR^Q52.UAS

(Pandey et al., 2007)

HDAC6^RNAi.UAS

exacerbates neurodegenerative disease

modeled by Zzzz\CGG^90.UAS.EGFP

(Todd et al., 2010)

HDAC6^KK100215

ameliorates Parkinson's disease

modeled by Hsap\LRRK2^{R1441C.UAS.Tag:FLAG}

(Godena et al., 2014)

modeled by Hsap\LRRK2^Y1699C.UAS

(Godena et al., 2014)

HDAC6^H237A.UAS

exacerbates Alzheimer's disease 1

modeled by Hsap\APP^{Aβ42.UAS.Tag:SS(rPENK)}

(Cheng et al., 2022)

HDAC6^{H237A.H664A.UAS}

ameliorates Alzheimer's disease 1

modeled by Hsap\APP^{Aβ42.UAS.Tag:SS(rPENK)}

(Cheng et al., 2022)

HDAC6^{UAS.Tag:V5,Tag:polyHis}

ameliorates neurodegenerative disease

modeled by Zzzz\CGG^90.UAS.EGFP

(Todd et al., 2010)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

HDAC6; histone deacetylase 6

14 of 14

300272

CHONDRODYSPLASIA WITH PLATYSPONDYLY, DISTINCTIVE BRACHYDACTYLY, HYDROCEPHALY, AND MICROPHTHALMIA

chondrodysplasia with platyspondyly, distinctive brachydactyly, hydrocephaly, and microphthalmia

HDAC10; histone deacetylase 10

6 of 14

608544

HDAC4; histone deacetylase 4

4 of 14

605314

NEURODEVELOPMENTAL DISORDER WITH CENTRAL HYPOTONIA AND DYSMORPHIC FACIES; NEDCHF

HDAC5; histone deacetylase 5

4 of 14

605315

HDAC7; histone deacetylase 7

4 of 14

606542

HDAC9; histone deacetylase 9

4 of 14

606543

AURICULOCONDYLAR SYNDROME 4; ARCND4

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Show neighbor-neighbor interactions:

Off

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

Select Layout:

Force Directed

Circle

Concentric

Legend:

Protein

RNA

Selected Interactor(s)

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

RNA-protein

Physical Interaction

Assay

References

HDAC6 - TBPH

anti tag coimmunoprecipitation, primer specific pcr

(Godena et al., 2011)

protein-protein

Physical Interaction

Assay

References

HDAC6 - Hsap\SNCA

anti bait coimmunoprecipitation, western blot

(Du et al., 2010)

HDAC6 - Hsc70-4

anti tag coimmunoprecipitation, anti tag western blot, enzymatic study, autoradiography

(Yan et al., 2017)

HDAC6 - Ufm1

anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based

(Rhee et al., 2014)

Summary of Genetic Interactions

esyN Network Diagram

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

esyN Network Key:

Suppression

Enhancement

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Yan et al., 2017)

enhanceable

(Dietz et al., 2015)

HDAC6

suppressible

Lsd-2

(Yan et al., 2017)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

anne

suppressible

HDAC6

(Wang et al., 2019)

Cep97

suppressible

HDAC6

(Dobbelaere et al., 2020)

suppressible

(Mao et al., 2014)

suppressible

(Yan et al., 2017)

suppressible

(Pandey et al., 2007)

Sirt2

enhanceable

HDAC6

(Dobbelaere et al., 2020)

Sirt2

suppressible

HDAC6

(Dobbelaere et al., 2020)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

58816

DroID - A comprehensive database of gene and protein interactions.

FBgn0026428

MIST (protein-protein) - An integrated Molecular Interaction Database

32461

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

gene_with_stop_codon_read_through

(Jungreis et al., 2011)

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-50

Cytogenetic map

13B6-13B6

Sequence location

X:15,333,310..15,340,360 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

13B6-13B6

Limits computationally determined from genome sequence between P{EP}hiw^EP1308 and P{EP}Ahcy13^EP1007

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

13B-13B

(Barlow, 1999.2.18)

Experimentally Determined Recombination Data

Location

1-50

(FlyBase, 2016)

1-50.6

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (16)

Genomic Clones (11)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (72)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

DPiM_LD43531

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0026428

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0026428

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Chen et al., 2008)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

HDAC6 regulates T-bar morphology.

(Miskiewicz et al., 2014)

Gene expression is increased in response to the presence of two copies of Scer\GAL4^hs.PB.

(Liu and Lehmann, 2008)

S2 cells which have been treated with dsRNA made from templates generated with primers directed against HDAC6 show no significant inhibition of cell growth.

(Foglietti et al., 2006)

The HDAC6 gene can be spliced into two isoforms, HDAC6-S, and HDAC6-L, containing 883 and 1128 amino acids, respectively. These isoforms are identical except that HDAC6-L has an additional 75 amino acids at the N terminus and 170 amino acids at the C terminus containing a ubiquitin binding protein domain.

(Cho et al., 2005)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: HDAC2 CG6170

(Wang, 1999.11)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (17)

Reported As

Symbol Synonym

CG6170

(Sun et al., 2023, Meadows, 2017.1.11, Çiçek et al., 2016, Ni et al., 2011.7.19, Keleman et al., 2009.8.5, Chen et al., 2008, Ni et al., 2008, Grieder et al., 2007, Foglietti et al., 2006)

DHDAC2

(Foglietti et al., 2006)

DmHDAC2

(Chen and Courey, 2000)

HDAC

(Padmanabhan et al., 2006, Guenther and Lazar, 2001, Jones and Kadonaga, 2000)

HDAC2

(Beaver et al., 2022, Ramirez Moreno et al., 2021, Beaver et al., 2020, Zhang et al., 2020, Milon et al., 2012)

HDAC6

(Willnow and Teleman, 2024, Wippich et al., 2023, Wu et al., 2023, Miao et al., 2022, Saunders et al., 2022, Zhao et al., 2022, Keegan and Hughes, 2021, Layalle et al., 2021, Yamaguchi et al., 2021, Gohel et al., 2020, Haudry et al., 2020, Jeon et al., 2020, Kang et al., 2020, Kankel et al., 2020, Vargas et al., 2020, Engel et al., 2019, Meltzer et al., 2019, Rodriguez-Fernandez et al., 2019, Sang Cho et al., 2019, Shimaji et al., 2019, Suda et al., 2019, Wang et al., 2019, Gene Disruption Project members, 2018-, Liu et al., 2018, Yan et al., 2018, Mohr et al., 2017, Perry et al., 2017, Transgenic RNAi Project members, 2017-, Yan et al., 2017, Hirano et al., 2016, Sarov et al., 2016, Schwartz et al., 2016, Aradska et al., 2015, Casci and Pandey, 2015, Dietz et al., 2015, Duncker et al., 2015, Nikalayevich and Ohkura, 2015, Godena et al., 2014, Ho et al., 2014, Mao et al., 2014, Miskiewicz et al., 2014, Mulakkal et al., 2014, Slattery et al., 2014, Zhang et al., 2014, Puram and Bonni, 2013, Rallis et al., 2013, Xiong et al., 2013, Meijering et al., 2012, Pushpavalli et al., 2012, Romano et al., 2012, Jungreis et al., 2011, Miśkiewicz et al., 2011, Nègre et al., 2011, Blanco et al., 2010, Fiesel et al., 2010, Lee et al., 2010, Todd et al., 2010, Svetec et al., 2009, Chen et al., 2008, Liu and Lehmann, 2008, Pallos et al., 2008, Pandey et al., 2007, Cho et al., 2005)

Hdac6

(Even et al., 2021, Dobbelaere et al., 2020)

dHDAC2

(Taylor-Harding et al., 2004, Mallin et al., 2000)

dHDAC6

(Wang et al., 2019, Muñoz-Soriano and Paricio, 2011, Du et al., 2010, Lee et al., 2010, Todd et al., 2010, Pandey et al., 2007, Kim et al., 2005, Taylor-Harding et al., 2004, Barlow et al., 2001)

dmHDA404

(Pandey et al., 2002)

hDAC6

(Manola et al., 2021)

hdac2

(Amcheslavsky et al., 2014)

hdac6

(Tsakiri et al., 2019, Gupta et al., 2016, Godena et al., 2011)

Name Synonyms

HDAC6

Histone Deacetylase 6

(Du et al., 2010)

Histone deacetylase 6

histone deacetylase 6

(Lee et al., 2014, Mulakkal et al., 2014, Muñoz-Soriano and Paricio, 2011, Fiesel et al., 2010, Todd et al., 2010)

histone deacetylase HDA2

(Barlow, 1999.2.18)

Secondary FlyBase IDs

Datasets (1)

Study focus (1)

Experimental Role

Project

Project Type

Title

bait_protein

modENCODE_regulation_chromatin

genome binding

Genome-wide localization of chromatin factors by ChIP-chip and ChIP-Seq.

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 103 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

32461

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

M9PJN5

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

M9PJN5

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0026428

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

32461/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0026428

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0026428

FlyMine - An integrated database for Drosophila genomics

FBgn0026428

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG6170

MARRVEL_MODEL - MARRVEL (model organism gene)

32461

Linkouts

BioGRID - A database of protein and genetic interactions.

58816

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0026428

DroID - A comprehensive database of gene and protein interactions.

FBgn0026428

DRSC - Results frm RNAi screens

FBgn0026428

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0026428

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0026428

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG6170

Flygut - An atlas of the Drosophila adult midgut

FBgn0026428

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0026428

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC014236

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (protein-protein) - An integrated Molecular Interaction Database

32461

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (142)

The following external sites may use different assemblies or annotations than FlyBase.

0.65

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