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Gene Dmel\Grip84

General Information
Symbol	Dmel\Grip84	Species	D. melanogaster
Name	gamma-tubulin ring protein 84	Annotation symbol	CG3917
Feature type	protein_coding_gene	FlyBase ID	FBgn0026430
Gene Model Status	Current	Stock availability	4 publicly available
Also Known As	Dgrip84, Dgrips84, GCP2
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	18D1-18D1	Sequence location	X:19,455,373..19,459,629 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene gamma-tubulin ring protein 84 is referred to in FlyBase by the symbol Dmel\Grip84 (CG3917, FBgn0026430). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: microtubule minus-end binding; gamma-tubulin binding. There is experimental evidence that it is involved in the biological process: centrosome organization; astral microtubule organization; meiosis; microtubule nucleation; mitosis; mitotic spindle organization; spindle assembly; regulation of cell cycle; spermatogenesis. 12 alleles are reported. The phenotype of these alleles is annotated with: trichogen cell. It has 5 annotated transcripts and 5 annotated polypeptides. Protein features are: Spc97/Spc98. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval trachea, adult testis. Comments on Affy2 ProbeSet: ProbeSet 1633188_a_at completely aligns to an exonic region common to each of the 5 FlyBase-annotated transcript isoforms of Grip84. Gene sequence location is X:19455373..19459629.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 18D1-18D1   Limits computationally determined from genome sequence between P{EP}EP1526&P{EP}PfrxEP1150 and P{EP}Tao-1EP1455
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Grip84 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.44 DGC clone LD12257 appears problematic: incomplete CDS
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Grip84-RA FBtr0074775  NM_167662   3145   926 Grip84-RB FBtr0074776  NM_167663   3069   852 Grip84-RC FBtr0074777  NM_078685   2970   819 Grip84-RD FBtr0301307  NM_001169326   3942   833 Grip84-RE FBtr0301308  NM_001169327   3046   893
Additional Transcript Data & Comments
Reported size (kB)	2.988 (longest cDNA) (Oegema et al., 1999)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Grip84-PA   FBpp0074544   106.8   926   6.39     NP_728264   AAN09501 Grip84-PB   FBpp0074545   98.5   852   6.17     NP_728265   AAF48971 Grip84-PC   FBpp0074546   94.7   819   6.41     NP_523409   AAN09502 Grip84-PD   FBpp0290522   95.7   833   6.86     NP_001162797   ACZ95331 Grip84-PE   FBpp0290523   103.0   893   6.61     NP_001162798   ACZ95332
Additional Polypeptide Data & Comments
Reported size (kDa)	819 (aa); 100 (kD observed) (Oegema et al., 1999)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Spc97/Spc98 (IPR007259)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA246343   AA438312   AA803199   AE014298 AAF48971   AE014298 AAN09501   AE014298 AAN09502   AE014298 ACZ95331   AE014298 ACZ95332   AF118379 AAD27816   AW942226   AY061148 AAL28696   BI169436   BI215963   BI232282   BI233293   BI240421   BP553075   BT021313   CK657909   CO263293   CO278795   CO304938   CO317485   CO321254   CO329432   EC078120   EC080306   EC080307   EC082137   EC088656   EC090202   EC196835   ES688607   ES688608   ES689243   ES689411   ES690652   ES691115   ES691129   ES691153   ES691159   ES691188   ES691234   ES691303   ES691346   ES691351   ES691396   ES691414   ES691638   ES691672   ES691674   ES691748   ES691751   ES691770   ES691804   ES691904   ES691907   ES691919   ES692507   ES693352   ES693373   ES693405   ES693795   ES693875   ES693877   ES693995   ES694012   ES694040   ES694265   ES694273   ES694319   ES694359   ES694370   ES694379   ES694383   ES694388   ES694398   ES694408   ES694409   ES694413   ES694416   ES694417   ES694421   ES694429   ES694433   ES694435   ES694457   ES694461   ES694465   ES694469   ES694474   ES694482   ES694494   ES694496   ES694501   ES694504   ES694506   ES694509   ES694511   ES694515   ES694525   ES694551   ES694555   ES694571   ES694595   ES694597   ES694603   ES694605   ES694609   ES694617   ES694624   ES694629   ES694631   ES694647   ES694652   ES694657   ES694660   ES694662   ES694664   ES694667   ES694668   ES694670   ES694671   ES694770   ES694782   ES694802   ES694815   ES694818   ES694822   ES694827   ES694830   ES694836   ES694838   ES694842   ES694845   ES694853   ES694854   ES694857   ES694860   ES694864   ES694906   ES694908   ES694911   ES694932   ES694941   ES694942   ES694945   ES694947   ES694953   ES694963   ES694975   ES694983   ES695021   ES695025   ES695028   ES695030   ES695034   ES695035   ES695049   ES695057   ES695060   ES695065   ES695069   ES695088   ES695089   ES695091   ES695095   ES695099   ES695113   ES695117   ES695118   ES695122   ES695126   ES695138   ES695145   ES695148   ES695151   ES695157   ES695182   ES695188   ES695416   ES695427   ES695444   GH941642   GH954475   GH959968   GH963827   GH974853   GH976468   GH981787
UniProtKB/Swiss-Prot	Q9XYP7
UniProtKB/TrEMBL	Q8IQW7 E1JJQ4 E1JJQ3
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism   (Fisher et al., 2012) Comment:rapidly degraded embryonic stage 11 -- 12   antennal primordium   (Fisher et al., 2012) Comment:reported as procephalon primordium central brain primordium   (Fisher et al., 2012) Comment:reported as procephalon primordium dorsal head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalon primordium lateral head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalon primordium ventral head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalon primordium visual primordium   (Fisher et al., 2012) Comment:reported as procephalon primordium ventral nerve cord primordium   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage     (Oegema et al., 1999)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
colocalizes_with centrosome inferred from direct assay (Oegema et al., 1999) gamma-tubulin small complex inferred from direct assay (assigned by UniProtKB) (Oegema et al., 1999) inferred from physical interaction with l(1)dd4 (Gunawardane et al., 2000) inferred from physical interaction with γTub23C (Gunawardane et al., 2000) colocalizes_with mitotic spindle inferred from direct assay (Oegema et al., 1999)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval trachea, adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    231.675 Larval Midgut    41.7 Larval Hindgut    70.4 Larval Malpighian Tubules    47.1 Larval Fat Body    56.6 Larval Salivary Gland    92.5 Larval Trachea    105.125 Larval Carcass    66.525 Adult Head    80.8 Adult Eye    73.475 Adult Brain    159.7 Adult Thoracic-Abdominal Ganglion    139.6 Adult Crop    71.7 Adult Midgut    49.9 Adult Hindgut    67.4 Adult Malpighian Tubules    35.8 Adult Fat Body    31.5 Adult Salivary Gland    81.7 Adult Heart    43.475 Adult VirginFemale Spermatheca    19.7 Adult InseminatedFemale Spermatheca    25.6 Adult Ovary    620.1 Adult Testis    125.4 Adult Male Accessory Gland    78 Adult Carcass    62.4 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    231.675 Larval Midgut    41.7 Larval Hindgut    70.4 Larval Malpighian Tubules    47.1 Larval Fat Body    56.6 Larval Salivary Gland    92.5 Larval Trachea    105.125 Larval Carcass    66.525 Adult Head    80.8 Adult Eye    73.475 Adult Brain    159.7 Adult Thoracic-Abdominal Ganglion    139.6 Adult Crop    71.7 Adult Midgut    49.9 Adult Hindgut    67.4 Adult Malpighian Tubules    35.8 Adult Fat Body    31.5 Adult Salivary Gland    81.7 Adult Heart    43.475 Adult VirginFemale Spermatheca    19.7 Adult InseminatedFemale Spermatheca    25.6 Adult Ovary  (620.1) Adult Testis    125.4 Adult Male Accessory Gland    78 Adult Carcass    62.4 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    231.675 Larval Midgut    41.7 Larval Hindgut    70.4 Larval Malpighian Tubules    47.1 Larval Fat Body    56.6 Larval Salivary Gland    92.5 Larval Trachea    105.125 Larval Carcass    66.525 Adult Head    80.8 Adult Eye    73.475 Adult Brain    159.7 Adult Thoracic-Abdominal Ganglion    139.6 Adult Crop    71.7 Adult Midgut    49.9 Adult Hindgut    67.4 Adult Malpighian Tubules    35.8 Adult Fat Body    31.5 Adult Salivary Gland    81.7 Adult Heart    43.475 Adult VirginFemale Spermatheca    19.7 Adult InseminatedFemale Spermatheca    25.6 Adult Ovary    620.1 Adult Testis    125.4 Adult Male Accessory Gland    78 Adult Carcass    62.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    231.675 Larval Midgut    41.7 Larval Hindgut    70.4 Larval Malpighian Tubules    47.1 Larval Fat Body    56.6 Larval Salivary Gland    92.5 Larval Trachea    105.125 Larval Carcass    66.525 Adult Head    80.8 Adult Eye    73.475 Adult Brain    159.7 Adult Thoracic-Abdominal Ganglion    139.6 Adult Crop    71.7 Adult Midgut    49.9 Adult Hindgut    67.4 Adult Malpighian Tubules    35.8 Adult Fat Body    31.5 Adult Salivary Gland    81.7 Adult Heart    43.475 Adult VirginFemale Spermatheca    19.7 Adult InseminatedFemale Spermatheca    25.6 Adult Ovary    620.1 Adult Testis    125.4 Adult Male Accessory Gland    78 Adult Carcass    62.4 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    231.675 Larval Midgut    41.7 Larval Hindgut    70.4 Larval Malpighian Tubules    47.1 Larval Fat Body    56.6 Larval Salivary Gland    92.5 Larval Trachea    105.125 Larval Carcass    66.525 Adult Head    80.8 Adult Eye    73.475 Adult Brain    159.7 Adult Thoracic-Abdominal Ganglion    139.6 Adult Crop    71.7 Adult Midgut    49.9 Adult Hindgut    67.4 Adult Malpighian Tubules    35.8 Adult Fat Body    31.5 Adult Salivary Gland    81.7 Adult Heart    43.475 Adult VirginFemale Spermatheca    19.7 Adult InseminatedFemale Spermatheca    25.6 Adult Ovary    620.1 Adult Testis    125.4 Adult Male Accessory Gland    78 Adult Carcass    62.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    231.675 Larval Midgut    41.7 Larval Hindgut    70.4 Larval Malpighian Tubules    47.1 Larval Fat Body    56.6 Larval Salivary Gland    92.5 Larval Trachea    105.125 Larval Carcass    66.525 Adult Head    80.8 Adult Eye    73.475 Adult Brain    159.7 Adult Thoracic-Abdominal Ganglion    139.6 Adult Crop    71.7 Adult Midgut    49.9 Adult Hindgut    67.4 Adult Malpighian Tubules    35.8 Adult Fat Body    31.5 Adult Salivary Gland    81.7 Adult Heart    43.475 Adult VirginFemale Spermatheca    19.7 Adult InseminatedFemale Spermatheca    25.6 Adult Ovary  620.1 Adult Testis    125.4 Adult Male Accessory Gland    78 Adult Carcass    62.4 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    231.675 Larval Midgut    41.7 Larval Hindgut    70.4 Larval Malpighian Tubules    47.1 Larval Fat Body    56.6 Larval Salivary Gland    92.5 Larval Trachea    105.125 Larval Carcass    66.525 Adult Head    80.8 Adult Eye    73.475 Adult Brain    159.7 Adult Thoracic-Abdominal Ganglion    139.6 Adult Crop    71.7 Adult Midgut    49.9 Adult Hindgut    67.4 Adult Malpighian Tubules    35.8 Adult Fat Body    31.5 Adult Salivary Gland    81.7 Adult Heart    43.475 Adult VirginFemale Spermatheca    19.7 Adult InseminatedFemale Spermatheca    25.6 Adult Ovary    620.1 Adult Testis    125.4 Adult Male Accessory Gland    78 Adult Carcass    62.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    231.675 Larval Midgut    41.7 Larval Hindgut    70.4 Larval Malpighian Tubules    47.1 Larval Fat Body    56.6 Larval Salivary Gland    92.5 Larval Trachea    105.125 Larval Carcass    66.525 Adult Head    80.8 Adult Eye    73.475 Adult Brain    159.7 Adult Thoracic-Abdominal Ganglion    139.6 Adult Crop    71.7 Adult Midgut    49.9 Adult Hindgut    67.4 Adult Malpighian Tubules    35.8 Adult Fat Body    31.5 Adult Salivary Gland    81.7 Adult Heart    43.475 Adult VirginFemale Spermatheca    19.7 Adult InseminatedFemale Spermatheca    25.6 Adult Ovary    620.1 Adult Testis    125.4 Adult Male Accessory Gland    78 Adult Carcass    62.4 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    80.8   NA  Eye    73.475   NA  Brain    159.7   231.675  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    139.6   NA  Crop    71.7   41.7  Midgut    49.9   70.4  Hindgut    67.4   47.1  Malpighian Tubules    35.8   56.6  Fat Body    31.5   92.5  Salivary Gland    81.7   NA  Heart    43.475   105.125  Trachea    NA   NA  VirginFemale Spermatheca    19.7   NA  InseminatedFemale Spermatheca    25.6   NA  Ovary    620.1   NA  Testis    125.4   NA  Male Accessory Gland    78   66.525  Carcass    62.4 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    10 central nervous system, pupae P8    9 head, virgin 1-day female    3 head, virgin 4-day female    2 head, virgin 20-day female    3 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    3 head, mated 1-day male    4 head, mated 4-day male    4 head, mated 20-day male    5 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    3 digestive system, 4-day adult    4 digestive system, 20-day adult    3 fat body, larvae L3 wandering    0 fat body, white prepupae    4 fat body, pupae P8    6 carcass, larvae L3 wandering    6 carcass, 1-day adult    2 carcass, 4-day adult    4 carcass, 20-day adult    2 ovary, virgin 4-day female    51 ovary, mated 4-day female    42 testis, mated 4-day male    8 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    10 central nervous system, pupae P8    9 head, virgin 1-day female    3 head, virgin 4-day female    2 head, virgin 20-day female    3 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    3 head, mated 1-day male    4 head, mated 4-day male    4 head, mated 20-day male    5 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    3 digestive system, 4-day adult    4 digestive system, 20-day adult    3 fat body, larvae L3 wandering    0 fat body, white prepupae    4 fat body, pupae P8    6 carcass, larvae L3 wandering    6 carcass, 1-day adult    2 carcass, 4-day adult    4 carcass, 20-day adult    2 ovary, virgin 4-day female  (51) ovary, mated 4-day female  (42) testis, mated 4-day male    8 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    10 central nervous system, pupae P8    9 head, virgin 1-day female    3 head, virgin 4-day female    2 head, virgin 20-day female    3 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    3 head, mated 1-day male    4 head, mated 4-day male    4 head, mated 20-day male    5 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    3 digestive system, 4-day adult    4 digestive system, 20-day adult    3 fat body, larvae L3 wandering    0 fat body, white prepupae    4 fat body, pupae P8    6 carcass, larvae L3 wandering    6 carcass, 1-day adult    2 carcass, 4-day adult    4 carcass, 20-day adult    2 ovary, virgin 4-day female    51 ovary, mated 4-day female    42 testis, mated 4-day male    8 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    10 central nervous system, pupae P8    9 head, virgin 1-day female    3 head, virgin 4-day female    2 head, virgin 20-day female    3 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    3 head, mated 1-day male    4 head, mated 4-day male    4 head, mated 20-day male    5 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    3 digestive system, 4-day adult    4 digestive system, 20-day adult    3 fat body, larvae L3 wandering    0 fat body, white prepupae    4 fat body, pupae P8    6 carcass, larvae L3 wandering    6 carcass, 1-day adult    2 carcass, 4-day adult    4 carcass, 20-day adult    2 ovary, virgin 4-day female    51 ovary, mated 4-day female    42 testis, mated 4-day male    8 accessory gland, mated 4-day male    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    10 central nervous system, pupae P8    9 head, virgin 1-day female    3 head, virgin 4-day female    2 head, virgin 20-day female    3 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    3 head, mated 1-day male    4 head, mated 4-day male    4 head, mated 20-day male    5 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    3 digestive system, 4-day adult    4 digestive system, 20-day adult    3 fat body, larvae L3 wandering    0 fat body, white prepupae    4 fat body, pupae P8    6 carcass, larvae L3 wandering    6 carcass, 1-day adult    2 carcass, 4-day adult    4 carcass, 20-day adult    2 ovary, virgin 4-day female    51 ovary, mated 4-day female    42 testis, mated 4-day male    8 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    10 central nervous system, pupae P8    9 head, virgin 1-day female    3 head, virgin 4-day female    2 head, virgin 20-day female    3 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    3 head, mated 1-day male    4 head, mated 4-day male    4 head, mated 20-day male    5 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    3 digestive system, 4-day adult    4 digestive system, 20-day adult    3 fat body, larvae L3 wandering    0 fat body, white prepupae    4 fat body, pupae P8    6 carcass, larvae L3 wandering    6 carcass, 1-day adult    2 carcass, 4-day adult    4 carcass, 20-day adult    2 ovary, virgin 4-day female  (51) ovary, mated 4-day female  (42) testis, mated 4-day male    8 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    10 central nervous system, pupae P8    9 head, virgin 1-day female    3 head, virgin 4-day female    2 head, virgin 20-day female    3 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    3 head, mated 1-day male    4 head, mated 4-day male    4 head, mated 20-day male    5 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    3 digestive system, 4-day adult    4 digestive system, 20-day adult    3 fat body, larvae L3 wandering    0 fat body, white prepupae    4 fat body, pupae P8    6 carcass, larvae L3 wandering    6 carcass, 1-day adult    2 carcass, 4-day adult    4 carcass, 20-day adult    2 ovary, virgin 4-day female    51 ovary, mated 4-day female    42 testis, mated 4-day male    8 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    10 central nervous system, pupae P8    9 head, virgin 1-day female    3 head, virgin 4-day female    2 head, virgin 20-day female    3 head, mated 1-day female    2 head, mated 4-day female    2 head, mated 20-day female    3 head, mated 1-day male    4 head, mated 4-day male    4 head, mated 20-day male    5 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    3 digestive system, 4-day adult    4 digestive system, 20-day adult    3 fat body, larvae L3 wandering    0 fat body, white prepupae    4 fat body, pupae P8    6 carcass, larvae L3 wandering    6 carcass, 1-day adult    2 carcass, 4-day adult    4 carcass, 20-day adult    2 ovary, virgin 4-day female    51 ovary, mated 4-day female    42 testis, mated 4-day male    8 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    79 embryo 02-04hr    11 embryo 04-06hr    25 embryo 06-08hr    22 embryo 08-10hr    16 embryo 10-12hr    10 embryo 12-14hr    7 embryo 14-16hr    6 embryo 16-18hr    4 embryo 18-20hr    3 embryo 20-22hr    2 embryo 22-24hr    3 larva L1    6 larva L2    6 larva L3 12hr old    5 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    10 white prepupae new    10 white prepupae 12hr    13 white prepupae 24hr    15 pupae 2d postWPP    12 pupae 3d postWPP    8 pupae 4d postWPP    13 adult male 01day    9 adult male 05day    12 adult male 30day    12 adult female 01day    40 adult female 05day    61 adult female 30day    61 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (79) embryo 02-04hr    11 embryo 04-06hr    25 embryo 06-08hr    22 embryo 08-10hr    16 embryo 10-12hr    10 embryo 12-14hr    7 embryo 14-16hr    6 embryo 16-18hr    4 embryo 18-20hr    3 embryo 20-22hr    2 embryo 22-24hr    3 larva L1    6 larva L2    6 larva L3 12hr old    5 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    10 white prepupae new    10 white prepupae 12hr    13 white prepupae 24hr    15 pupae 2d postWPP    12 pupae 3d postWPP    8 pupae 4d postWPP    13 adult male 01day    9 adult male 05day    12 adult male 30day    12 adult female 01day  (40) adult female 05day  (61) adult female 30day  (61) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    79 embryo 02-04hr    11 embryo 04-06hr    25 embryo 06-08hr    22 embryo 08-10hr    16 embryo 10-12hr    10 embryo 12-14hr    7 embryo 14-16hr    6 embryo 16-18hr    4 embryo 18-20hr    3 embryo 20-22hr    2 embryo 22-24hr    3 larva L1    6 larva L2    6 larva L3 12hr old    5 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    10 white prepupae new    10 white prepupae 12hr    13 white prepupae 24hr    15 pupae 2d postWPP    12 pupae 3d postWPP    8 pupae 4d postWPP    13 adult male 01day    9 adult male 05day    12 adult male 30day    12 adult female 01day    40 adult female 05day    61 adult female 30day    61 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    79 embryo 02-04hr    11 embryo 04-06hr    25 embryo 06-08hr    22 embryo 08-10hr    16 embryo 10-12hr    10 embryo 12-14hr    7 embryo 14-16hr    6 embryo 16-18hr    4 embryo 18-20hr    3 embryo 20-22hr    2 embryo 22-24hr    3 larva L1    6 larva L2    6 larva L3 12hr old    5 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    10 white prepupae new    10 white prepupae 12hr    13 white prepupae 24hr    15 pupae 2d postWPP    12 pupae 3d postWPP    8 pupae 4d postWPP    13 adult male 01day    9 adult male 05day    12 adult male 30day    12 adult female 01day    40 adult female 05day    61 adult female 30day    61 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    79 embryo 02-04hr    11 embryo 04-06hr    25 embryo 06-08hr    22 embryo 08-10hr    16 embryo 10-12hr    10 embryo 12-14hr    7 embryo 14-16hr    6 embryo 16-18hr    4 embryo 18-20hr    3 embryo 20-22hr    2 embryo 22-24hr    3 larva L1    6 larva L2    6 larva L3 12hr old    5 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    10 white prepupae new    10 white prepupae 12hr    13 white prepupae 24hr    15 pupae 2d postWPP    12 pupae 3d postWPP    8 pupae 4d postWPP    13 adult male 01day    9 adult male 05day    12 adult male 30day    12 adult female 01day    40 adult female 05day    61 adult female 30day    61 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (79) embryo 02-04hr    11 embryo 04-06hr    25 embryo 06-08hr    22 embryo 08-10hr    16 embryo 10-12hr    10 embryo 12-14hr    7 embryo 14-16hr    6 embryo 16-18hr    4 embryo 18-20hr    3 embryo 20-22hr    2 embryo 22-24hr    3 larva L1    6 larva L2    6 larva L3 12hr old    5 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    10 white prepupae new    10 white prepupae 12hr    13 white prepupae 24hr    15 pupae 2d postWPP    12 pupae 3d postWPP    8 pupae 4d postWPP    13 adult male 01day    9 adult male 05day    12 adult male 30day    12 adult female 01day  (40) adult female 05day  (61) adult female 30day  (61) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    79 embryo 02-04hr    11 embryo 04-06hr    25 embryo 06-08hr    22 embryo 08-10hr    16 embryo 10-12hr    10 embryo 12-14hr    7 embryo 14-16hr    6 embryo 16-18hr    4 embryo 18-20hr    3 embryo 20-22hr    2 embryo 22-24hr    3 larva L1    6 larva L2    6 larva L3 12hr old    5 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    10 white prepupae new    10 white prepupae 12hr    13 white prepupae 24hr    15 pupae 2d postWPP    12 pupae 3d postWPP    8 pupae 4d postWPP    13 adult male 01day    9 adult male 05day    12 adult male 30day    12 adult female 01day    40 adult female 05day    61 adult female 30day    61 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    79 embryo 02-04hr    11 embryo 04-06hr    25 embryo 06-08hr    22 embryo 08-10hr    16 embryo 10-12hr    10 embryo 12-14hr    7 embryo 14-16hr    6 embryo 16-18hr    4 embryo 18-20hr    3 embryo 20-22hr    2 embryo 22-24hr    3 larva L1    6 larva L2    6 larva L3 12hr old    5 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    10 white prepupae new    10 white prepupae 12hr    13 white prepupae 24hr    15 pupae 2d postWPP    12 pupae 3d postWPP    8 pupae 4d postWPP    13 adult male 01day    9 adult male 05day    12 adult male 30day    12 adult female 01day    40 adult female 05day    61 adult female 30day    61 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    15 Schneider line 2 Sg4    11 embryonic 1182-4H    13 embryonic GM2    11 embryonic Kc167    9 embryonic S1    10 embryonic S3    13 leg disc CME L1    11 wing disc CME-W2    10 wing disc ML-DmD8    11 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    10 wing disc ML-DmD21    7 wing disc ML-DmD32    9 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    10 mixed discs ML-DmD4-c1    7 CNS ML-DmBG1-c1    16 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    7 ovary fGS/OSS    20 ovary OSC    13 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    15 Schneider line 2 Sg4    11 embryonic 1182-4H    13 embryonic GM2    11 embryonic Kc167    9 embryonic S1    10 embryonic S3    13 leg disc CME L1    11 wing disc CME-W2    10 wing disc ML-DmD8    11 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    10 wing disc ML-DmD21    7 wing disc ML-DmD32    9 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    10 mixed discs ML-DmD4-c1    7 CNS ML-DmBG1-c1    16 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    7 ovary fGS/OSS    20 ovary OSC    13 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    15 Schneider line 2 Sg4    11 embryonic 1182-4H    13 embryonic GM2    11 embryonic Kc167    9 embryonic S1    10 embryonic S3    13 leg disc CME L1    11 wing disc CME-W2    10 wing disc ML-DmD8    11 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    10 wing disc ML-DmD21    7 wing disc ML-DmD32    9 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    10 mixed discs ML-DmD4-c1    7 CNS ML-DmBG1-c1    16 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    7 ovary fGS/OSS    20 ovary OSC    13 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    15 Schneider line 2 Sg4    11 embryonic 1182-4H    13 embryonic GM2    11 embryonic Kc167    9 embryonic S1    10 embryonic S3    13 leg disc CME L1    11 wing disc CME-W2    10 wing disc ML-DmD8    11 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    10 wing disc ML-DmD21    7 wing disc ML-DmD32    9 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    10 mixed discs ML-DmD4-c1    7 CNS ML-DmBG1-c1    16 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    7 ovary fGS/OSS    20 ovary OSC    13 ovary OSS    10 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    15 Schneider line 2 Sg4    11 embryonic 1182-4H    13 embryonic GM2    11 embryonic Kc167    9 embryonic S1    10 embryonic S3    13 leg disc CME L1    11 wing disc CME-W2    10 wing disc ML-DmD8    11 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    10 wing disc ML-DmD21    7 wing disc ML-DmD32    9 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    10 mixed discs ML-DmD4-c1    7 CNS ML-DmBG1-c1    16 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    7 ovary fGS/OSS    20 ovary OSC    13 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    15 Schneider line 2 Sg4    11 embryonic 1182-4H    13 embryonic GM2    11 embryonic Kc167    9 embryonic S1    10 embryonic S3    13 leg disc CME L1    11 wing disc CME-W2    10 wing disc ML-DmD8    11 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    10 wing disc ML-DmD21    7 wing disc ML-DmD32    9 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    10 mixed discs ML-DmD4-c1    7 CNS ML-DmBG1-c1    16 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    7 ovary fGS/OSS    20 ovary OSC    13 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    15 Schneider line 2 Sg4    11 embryonic 1182-4H    13 embryonic GM2    11 embryonic Kc167    9 embryonic S1    10 embryonic S3    13 leg disc CME L1    11 wing disc CME-W2    10 wing disc ML-DmD8    11 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    10 wing disc ML-DmD21    7 wing disc ML-DmD32    9 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    10 mixed discs ML-DmD4-c1    7 CNS ML-DmBG1-c1    16 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    7 ovary fGS/OSS    20 ovary OSC    13 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    15 Schneider line 2 Sg4    11 embryonic 1182-4H    13 embryonic GM2    11 embryonic Kc167    9 embryonic S1    10 embryonic S3    13 leg disc CME L1    11 wing disc CME-W2    10 wing disc ML-DmD8    11 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    10 wing disc ML-DmD21    7 wing disc ML-DmD32    9 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    10 mixed discs ML-DmD4-c1    7 CNS ML-DmBG1-c1    16 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    7 ovary fGS/OSS    20 ovary OSC    13 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    5 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    25 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    40 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    28 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    26 Paraquat 10 mM 48 hrs, 4-day adult    27 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    5 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    25 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3  (40) Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (28) Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult  26 Paraquat 10 mM 48 hrs, 4-day adult  (27) Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    5 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    25 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    40 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    28 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    26 Paraquat 10 mM 48 hrs, 4-day adult    27 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    5 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    25 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    40 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    28 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    26 Paraquat 10 mM 48 hrs, 4-day adult    27 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    5 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    25 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    40 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    28 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    26 Paraquat 10 mM 48 hrs, 4-day adult    27 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    5 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    25 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3  (40) Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  28 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult  26 Paraquat 10 mM 48 hrs, 4-day adult  27 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    5 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    25 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    40 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    28 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    26 Paraquat 10 mM 48 hrs, 4-day adult    27 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    5 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    13 Cadmium 100 mM 48 hrs, 4-day adult    25 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    13 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    40 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    28 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    26 Paraquat 10 mM 48 hrs, 4-day adult    27 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_06
External Data & Images
Linkouts	BDGP expression data • PC00480 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0026430 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3917-RC FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Grip84 Stages(s) 7-8 Stages(s) 11-12
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | recessive Grip84PG36 Grip84PG66 Grip84R20 partially lethal - majority die | recessive Grip84PG36 viable, with Scer\GAL4pnr-MD237 Grip84GD11106 Sterility Allele male sterile Grip84PG36 Other Phenotypes Allele meiotic cell cycle defective Grip84PG36 mitotic cell cycle defective Grip84PG36 mitotic cell cycle defective | third instar larval stage Grip84PG66 Grip84R20 visible, with Scer\GAL4pnr-MD237 Grip84GD11106 Phenotype manifest in Allele aster & primary spermatocyte Grip84PG36 chromosome & procephalic neuroblast | third instar larval stage Grip84PG36 Grip84PG66 Grip84R20 cuticle & abdomen Grip84PG36 macrochaeta & thorax Grip84PG36 Nebenkern & onion stage spermatid Grip84PG36 Nebenkern & onion stage spermatid | supernumerary Grip84PG36 nucleus & onion stage spermatid Grip84PG36 nucleus & onion stage spermatid | supernumerary Grip84PG36 pericentriolar material & primary spermatocyte Grip84PG36 pericentriolar material & procephalic neuroblast | third instar larval stage Grip84R20 spindle & primary spermatocyte Grip84PG36 spindle & procephalic neuroblast | third instar larval stage Grip84R20 trichogen cell, with Scer\GAL4pnr-MD237 Grip84GD11106
Classical Alleles ( 6 )
For All Classical Alleles Show
Allele of Grip84 Class Mutagen Stocks Known lesion Grip84PG36 hypomorphic allele - genetic evidence Delta2-3 0 -- Grip84PG66 loss of function allele Delta2-3 0 -- Grip84R20 Delta2-3 0 Yes Grip84Δ141 P-element activity 0 Yes Grip84Δ163 P-element activity 0 Yes Grip84Δ33 P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Grip84 Class Mutagen Stocks Known lesion Grip84GD11106 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Grip84HMS00627 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Grip84KK101253 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Grip84t4.4 in vitro construct - genomic fragment 0 Yes Grip84T:Zzzz\FLAG in vitro construct - coding region fusion 0 Yes Grip84Ubi-p63E.PC in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Partially disrupted in	Df(1)carΔ33 (Akbar et al., 2009) Df(1)carΔ141 (Akbar et al., 2009) Df(1)carΔ163 (Akbar et al., 2009)
Disrupted in	Df(1)14.4 (Gomez et al., 2012)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11106} NA P{KK101253} NA P{TRiP.HMS00627} NA characterization construct P{car+t4.4} NA P{Ubi-p63E-Grip84.C} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap binary system P{GawB}Grip84PG36 No P{GawB}Grip84PG66 No
Gene Ontology: Function, Process & Cellular Component ( 19 unique terms )
Terms Based on Experimental Evidence ( 14 terms )
Molecular Function
CV term Evidence References
gamma-tubulin binding inferred from direct assay (Gunawardane et al., 2003) contributes_to microtubule minus-end binding inferred from direct assay (Gunawardane et al., 2000)
Biological Process
CV term Evidence References
astral microtubule organization inferred from mutant phenotype (Colombie et al., 2006) centrosome organization inferred from mutant phenotype (Goshima et al., 2007, Colombie et al., 2006, Müller et al., 2010) meiosis inferred from mutant phenotype (Colombie et al., 2006) microtubule nucleation inferred from direct assay (Gunawardane et al., 2000) inferred from direct assay (assigned by UniProtKB) (Oegema et al., 1999) mitosis inferred from mutant phenotype (Colombie et al., 2006, Ducat et al., 2008) mitotic spindle organization inferred from mutant phenotype (Goshima et al., 2007) regulation of cell cycle inferred from mutant phenotype (Muller et al., 2006) spermatogenesis inferred from mutant phenotype (Colombie et al., 2006) spindle assembly inferred from mutant phenotype (Colombie et al., 2006)
Cellular Component
CV term Evidence References
colocalizes_with centrosome inferred from direct assay (Oegema et al., 1999) gamma-tubulin small complex inferred from direct assay (assigned by UniProtKB) (Oegema et al., 1999) inferred from physical interaction with l(1)dd4 (Gunawardane et al., 2000) inferred from physical interaction with γTub23C (Gunawardane et al., 2000) colocalizes_with mitotic spindle inferred from direct assay (Oegema et al., 1999)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
microtubule binding inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000) tubulin binding non-traceable author statement (FlyBase, 1992-)
Biological Process
CV term Evidence References
microtubule-based process inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000)
Cellular Component
CV term Evidence References
gamma-tubulin small complex non-traceable author statement (Zheng, 1999.1.6) microtubule associated complex inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000) spindle pole inferred from electronic annotation with InterPro:IPR007259 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Grip84 - γTub23C anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Grip84 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 59246 DroID - A comprehensive database of gene and protein interactions. • FBgn0026430 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32946
Orthologs
OrthoDB Orthologs (38) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6G7CHS Dipteran inclusive ortholog search EOG669R2V Insect inclusive ortholog search EOG69S528 Arthropod inclusive ortholog search EOG6CJSZ2 Metazoa inclusive ortholog search EOG68Q0BX
Orthologs in Drosophila Species (EOG6G7CHS)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Grip84     Drosophila simulans   Dsim\GD15576 Y   Drosophila sechellia   Dsec\GM22736 Y   Drosophila erecta   Dere\GG18049 Y   Drosophila yakuba   Dyak\GE17380 Y   Drosophila ananassae   Dana\GF20484 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA17771 Y   Drosophila persimilis   Dper\GL14777 Y   Drosophila willistoni   Dwil\GK25106 Y   Drosophila virilis   Dvir\GJ15836 Y   Drosophila mojavensis   Dmoj\GI16432 Y   Drosophila grimshawi   Dgri\GH17863
Orthologs in non-Drosophila Dipterans (EOG669R2V)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL013903   Anopheles gambiae Malaria mosquito  Agam\AGAP005575   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ015217
Orthologs in non-Dipteran Insects (EOG69S528)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB46012   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG009129   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH14694   Atta cephalotes Leafcutter ant  Acep\ACEP24121   Camponotus floridanus Florida carpenter ant  Cflo\CFLO13955   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL18829   Linepithema humile Argentine ant  Lhum\LH18832   Linepithema humile Argentine ant  Lhum\LH18836   Pogonomyrmex barbatus Red harvester ant  Pbar\PB11644   Solenopsis invicta Red fire ant  Sinv\SINV19079   Acyrthosiphon pisum Pea aphid  Apim\ACYPI003879   Bombyx mori Silkmoth  Bmor\BGIBMGA000979   Pediculus humanus Human body louse  Phum\PHUM028000   Tribolium castaneum Red flour beetle  Tcas\GLEAN_07942
Orthologs in non-Insect Arthropods (EOG6CJSZ2)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\matK   Ixodes scapularis Deer tick  Isca\ISCW013617
Orthologs in non-Arthropod Metazoa (EOG68Q0BX)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_000278gn   Danio rerio Zebrafish  Drer\tubgcp2   Xenopus tropicalis Western clawed frog  Xtro\tubgcp2   Gallus gallus Domestic chicken  Ggal\TUBGCP2   Mus musculus House mouse  Mmus\Tubgcp2   Rattus norvegicus Norway rat  Rnor\Tubgcp2   Homo sapiens Human  Hsap\TUBGCP2
Human Orthologs (1)
Gene OMIM HGNC Hsap\TUBGCP2
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD15576 Drosophila sechellia Dsec\GM22736 Drosophila erecta Dere\GG18049 Drosophila yakuba Dyak\GE17380 Drosophila ananassae Dana\GF20484 Drosophila pseudoobscura pseudoobscura Dpse\GA17771 Drosophila persimilis Dper\GL14777 Drosophila willistoni Dwil\GK25106 Drosophila virilis Dvir\GJ15836 Drosophila mojavensis Dmoj\GI16432 Drosophila grimshawi Dgri\GH16357
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	33548 y1 sc* v1; P{TRiP.HMS00627}attP2
VDRC	v105640 P{KK101253}VIE-260B v34731 w1118; P{GD11106}v34731 v34730 w1118; P{GD11106}v34730/TM3
Genomic Clones ( 2 )
	BACR10M08 BACR27L16 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 180 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD12257 RE12810
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GM10386 LD05202 RE10613 RE22744 RE28328 RE29146 RE29596 RE37263
Other clones	123934 163855 190589 CK01.26A.C6 CK01.105B.A2 EK088025 EK131702 EK246753 EK268339 EK290602 EK292830 FGM222D08 RC0-DA0001-120700-011-A08 RC0-DA0001-120700-011-C12 RC0-DA0001-120700-011-G12 RC0-DA0001-120700-012-A03 RC0-DA0001-120700-012-A06 RC0-DA0001-120700-013-A03 RC0-DA0001-120700-013-E10 RC0-DA0001-120700-015-C03 RC0-DA0001-120700-016-A10 RC0-DA0001-120700-016-A12 RC0-DA0001-120700-016-H07 RC0-DA0001-120700-018-d04 RC0-DA0001-120700-018-e01 RC0-DA0001-120700-019-D06 RC0-DA0001-120700-019-G08 RC0-DA0001-120700-111-B11 RC0-DA0001-120700-112-D12 RC0-DA0001-130700-114-A09 RC0-DA0001-130700-114-B02 RC0-DA0001-130700-116-B01 RC0-DA0001-130700-116-B11 RC0-DA0001-130700-116-E10 RC0-DA0001-130700-117-A12 RC0-DA0001-130700-118-A09 RC0-DA0001-130700-121-C01 RC0-DA0001-130700-121-C04 RC0-DA0001-130700-121-E07 RC0-DL0001-140700-011-A09 RC0-DL0001-140700-011-C04 RC0-DL0001-140700-011-D07 RC0-DL0001-140700-011-D12 RC0-DL0001-140700-011-E09 RC0-DL0001-140700-011-G10 RC0-DL0001-140700-012-A07 RC0-DL0001-140700-012-A09 RC0-DL0001-140700-012-B08 RC0-DL0001-140700-012-C01 RC0-DL0001-140700-012-C02 RC0-DL0001-140700-012-D04 RC0-DL0001-140700-012-E07 RC0-DL0001-140700-012-E12 RC0-DL0001-140700-012-F03 RC0-DL0001-140700-012-F08 RC0-DL0001-140700-014-B07 RC0-DL0001-140700-014-C05 RC0-DL0001-140700-014-C10 RC0-DL0001-140700-014-D05 RC0-DL0001-140700-014-E01 RC0-DL0001-140700-014-E12 RC0-DL0001-140700-014-H08 RC0-DL0001-140700-015-B08 RC0-DL0001-140700-015-B12 RC0-DL0001-140700-015-C06 RC0-DL0001-140700-015-D02 RC0-DL0001-140700-015-D05 RC0-DL0001-140700-015-E02 RC0-DL0001-140700-015-E06 RC0-DL0001-140700-015-E08 RC0-DL0001-140700-015-F05 RC0-DL0001-140700-015-H03 RC0-DL0001-140700-016-F05 RC0-DL0001-140700-016-G09 RC0-DL0001-140700-017-D01 RC0-DL0001-140700-018-a12 RC0-DL0001-140700-018-b06 RC0-DL0001-140700-018-c05 RC0-DL0001-140700-018-c12 RC0-DL0001-140700-018-d05 RC0-DL0001-140700-018-f04 RC0-DL0001-140700-018-g07 RC0-DL0001-140700-018-h11 RC0-DL0001-140700-019-A01 RC0-DL0001-140700-019-D08 RC0-DL0001-140700-019-E05 RC0-DL0001-140700-019-F07 RC0-DL0001-140700-019-F11 RC0-DL0001-140700-019-G04 RC0-DL0001-140700-019-G06 RC0-DL0001-140700-019-G11 RC0-DL0001-140700-019-H03 RC0-DL0001-140700-019-H04 RC0-DL0001-140700-019-H07 RC0-DL0001-140700-019-H10 RC0-DL0001-140700-110-A07 RC0-DL0001-140700-110-D03 RC0-DL0001-140700-111-A08 RC0-DL0001-140700-111-D11 RC0-DL0001-140700-111-F02 RC0-DL0001-140700-111-G05 RC0-DL0001-140700-111-H04 RC0-DL0001-140700-111-H10 RC0-DL0001-140700-112-A10 RC0-DL0001-140700-112-A12 RC0-DL0001-140700-112-B06 RC0-DL0001-140700-112-C08 RC0-DL0001-140700-112-E07 RC0-DL0001-140700-112-E08 RC0-DL0001-140700-112-F02 RC0-DL0001-140700-112-F06 RC0-DL0001-140700-112-G09 RC0-DL0001-140700-114-E04 RC0-DL0001-140700-114-F05 RC0-DL0001-140700-114-F09 RC0-DL0001-140700-114-F12 RC0-DL0001-140700-116-D06 RC0-DL0001-140700-116-H04 RC0-DL0001-140700-116-H10 RC0-DL0001-140700-117-A12 RC0-DL0001-140700-117-B12 RC0-DL0001-140700-117-D11 RC0-DL0001-140700-117-G07 RC0-DL0001-140700-118-B05 RC0-DL0001-140700-118-C02 RC0-DL0001-140700-118-E02 RC0-DL0001-140700-118-G08 RC0-DL0001-140700-119-A07 RC0-DL0001-140700-119-C05 RC0-DL0001-140700-119-F10 RC0-DL0001-140700-120-E02 RC0-DL0001-140700-120-G07 RC0-DL0001-140700-120-G11 RC0-DL0001-140700-120-H02 RC0-DL0001-140700-120-H12 RC0-DL0001-140700-121-A02 RC0-DL0001-140700-121-A12 RC0-DL0001-140700-121-D03 RC0-DL0001-140700-121-E04 RC0-DL0001-140700-121-F05 RC0-DL0001-140700-121-G11 RC0-DL0001-140700-121-H06 RC0-DL0001-140700-122-C12 RC0-DL0001-140700-122-D02 RC0-DL0001-140700-122-E02 RC0-DL0001-140700-122-E11 RC0-DL0001-140700-122-F04 RC0-DL0001-140700-122-G10 RC0-DL0001-140700-123-A02 RC0-DL0001-140700-123-E04 RC0-DL0001-140700-123-E07 RC0-DL0001-140700-123-G06 RC0-DL0001-140700-123-G06_1 RC0-DL0001-140700-123-G12 RC0-DL0001-140700-123-H09 RC0-DL0001-140700-124-C02 RC0-DL0001-140700-124-D01 RC0-DL0001-140700-124-G07 RC0-DL0001-140700-124-H05 RC0-DL0001-140700-124-H12 RC0-DL0001-140700-125-B07 RC0-DL0001-140700-125-H08 RC0-DL0001-140700-126-B03 RP004113697 RP004228370 RP004263768 RP004319286 RP004355300 RP004511055 RP004550090
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0026430 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32946
Antibody Information
	polyclonal (Oegema et al., 1999)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	RNAi screen using dsRNA made from templates generated with primers directed against this gene results in the formation of an aberrantly long, monopolar spindle when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA. (Goshima et al., 2007) SL2 cells treated with dsRNA against Grip84 show a clear increase in the mitotic index compared to control cells. The treated cells show bipolar monastral and monopolar anastral spindle organisation with metaphase-like chromosome arrangements. (Muller et al., 2006) The interaction between Grip84 and γ-Tubulin facilitates γ-Tubulin binding to GTP. (Gunawardane et al., 2003) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) Identification: Protein identified as part of a γ tubulin ring complex. (Oegema et al., 1999)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078685 NM_167662 NM_167663 NM_001169326 NM_001169327 RefSeq (Proteins) • NP_523409 NP_728264 NP_728265 NP_001162797 NP_001162798 DDBJ / EMBL / GenBank • AA438312 AAD27816 AAF48971 AAL28696 AAN09501 AAN09502 ACZ95331 ACZ95332 AF118379 AW942226 AY061148 Entrez Gene - A searchable database of RefSeq genes. • 32946 UniProtKB/Swiss-Prot • Q9XYP7 UniProtKB/TrEMBL • E1JJQ3 E1JJQ4 Q8IQW7
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Spc97/Spc98 (IPR007259) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • PC00480
Linkouts
	BioGRID - A database of protein and genetic interactions • 59246 DroID - A comprehensive database of gene and protein interactions. • FBgn0026430 DRSC - Results from RNAi screens. • FBgn0026430 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0026430 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3917-RC FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0026430 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32946 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /genebrief/grip84.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32946 modMine - Data generated by the modENCODE project. • FBgn0026430
Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	CG3917 (Bourbon et al., 2002, Goldstein and Gunawardena, 2000, Goshima et al., 2007, Ducat et al., 2008, Keleman et al., 2009.8.5, Ni et al., 2010.12.1) Dgrip84 (Stumpff et al., 2005, Stumpff et al., 2004, Kawaguchi and Zheng, 2004, Cha et al., 2002, Gunawardane et al., 2000, Gunawardane et al., 2000, Goldstein and Gunawardena, 2000, Dias et al., 1999, Sibon et al., 2000, Gunawardane et al., 1999, Zheng, 1999.1.6, Oegema et al., 1999, Verollet et al., 2006, Goshima et al., 2007, Vogt et al., 2006, Colombie et al., 2006, Goshima et al., 2007, Minakhina et al., 2007, Moutinho-Pereira et al., 2009, Jankovics and Brunner, 2006, Zhang and Megraw, 2007, Wiese, 2008, Trammell et al., 2008, Bouissou et al., 2009) DGrip84 (Brodu et al., 2010) Dgrips84 (Gunawardane et al., 2003, Blagden and Glover, 2003) GCP2 (Jeng and Stearns, 1999, Wiese, 2008) Grip84 (Muller et al., 2006, Bakal et al., 2007, Berezikov et al., 2011, Ducat et al., 2008, Straub et al., 2008, Ruby et al., 2007, Habermann et al., 2012, Gopalakrishnan et al., 2012) grip84 (Akbar et al., 2009) l(1)tPG36 (Colombie et al., 2006) l(1)tPG66 (Colombie et al., 2006)
Name Synonym	DGrip84 (Brodu et al., 2010) gamma-tubulin ring protein 84
Secondary FlyBase IDs
References ( 57 )
Generate a list of	All references relating to this gene ( 57 )
List References by type	Research paper  ( 32 ) Supplementary material  ( 8 ) Review  ( 2 ) Personal communication to FlyBase  ( 6 ) Abstract  ( 3 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 4 )
	Gomez et al., 2012, J. Cell Biol. 199(7): 1131--1143 Tao controls epithelial morphogenesis by promoting Fasciclin 2 endocytosis. [FBrf0220436] Gopalakrishnan et al., 2012, Nat. Cell Biol. 14(8): 865--873 Tubulin nucleotide status controls Sas-4-dependent pericentriolar material recruitment. [FBrf0219801] Habermann et al., 2012, Mol. Cell. Biol. 32(17): 3554--3569 Functional Analysis of Centrosomal Kinase Substrates in Drosophila melanogaster Reveals a New Function of the Nuclear Envelope Component Otefin in Cell Cycle Progression. [FBrf0219185] Berezikov et al., 2011, Genome Res. 21(2): 203--215 Deep annotation of Drosophila melanogaster microRNAs yields insights into their processing, modification, and emergence. [FBrf0213080] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...