• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • RNA-Seq Search
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • GBrowse 2 Beta
    • CytoSearch
    • Feature Mapper
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Current release
  • Archived releases
  • Map Conversion
  • FTP site:
  • Releases (FTP)
  • Genomes (FTP)
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Vectors & Constructs
  • Other links:
  • BDGP
  • DGRC
  • DIS by issue
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\Drp1

General Information
Symbol	Dmel\Drp1	Species	D. melanogaster
Name	Dynamin related protein 1	Annotation symbol	CG3210
Feature type	protein_coding_gene	FlyBase ID	FBgn0026479
Gene Model Status	Current	Stock availability	12 publicly available
Also Known As	l(2)ND2, l(2)ND3, Drp-1, Drp
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	23A1-23A1	Sequence location	2L:2,581,281..2,585,430 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Dynamin related protein 1 is referred to in FlyBase by the symbol Dmel\Drp1 (CG3210, FBgn0026479). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: GTP binding; GTPase activity. There is experimental evidence that it is involved in the biological process: sperm mitochondrion organization; mitochondrion localization; intracellular distribution of mitochondria; cytokinesis; vesicle organization; mitochondrion organization. 24 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; Nebenkern; embryonic/larval neuromuscular junction; mitochondrion; ventral furrow. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Dynamin; Dynamin GTPase effector; Dynamin central domain; Dynamin, GTPase domain; Dynamin, GTPase region, conserved site; GTPase effector domain, GED. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval Malpighian tubules, larval salivary gland, adult testis. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult brain, adult crop, larval/adult midgut, larval/adult hindgut, adult Malpighian tubules, adult heart, larval/adult fat body, adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1641560_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Drp1. Gene sequence location is 2L:2581281..2585430.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03	Controlled Vocabulary Terms positive regulation of mitochondrial fission
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 23A1-23A1   Limits computationally determined from genome sequence between P{PZ}dpp10638 and P{EP}EP832
Experimentally Determined Cytological Location
Cytogenetic map Notes References 22F-23A   Determined by comparing Celera genomic sequence with sequence from BDGP BAC and P1 clones.   (Lloyd et al., 2000)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Drp1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.47 Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Drp1-RA FBtr0077744  NM_134850   2711   735 Drp1-RB FBtr0335173  NM_001273017   2868   735
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Drp1-PA   FBpp0077424   82.6   735   6.98     NP_608694   AAF51235 Drp1-PB   FBpp0307166   82.6   735   6.98     NP_001259946   AGB92483
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Dynamin central domain (IPR000375) Dynamin, GTPase domain (IPR001401) Dynamin GTPase effector (IPR003130) Dynamin, GTPase region, conserved site (IPR019762) P-loop containing nucleoside triphosphate hydrolase (IPR027417) GTPase effector domain, GED (IPR020850) Dynamin (IPR022812)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA695034   AE014134 AAF51235   AC002444   AE014134 AGB92483   AI260038   AI388116   AI388411   AI390009   AI511778   AI516455   AI517711   AI530822   AI534399   AI542810   AW941162   AY069246 AAL39391   BF486898   BF487402   BF487860   BF488223   BF488854   BF489344   BF491427   BF492081   BF493324   BF493520   BF494211   BF494965   BF495227   BF495569   BF497786   BF498562   BF499886   BF500478   BF501800   BF501976   BF502151   BF505275   BF505578   BF505640   BF505705   BF505707   BG634226   BH740812   BI167883   BI169952   BI170219   BI239884   BI577137   BP555767   BP558357   BP558358   BT001269 AAN71025   BT133244   CK659536   CO153439   CO303225   CO341020   CZ484989   EC053751   EC077895   EC087091   EC088512   EC238113   EC260384   EC265461   EL869920   EL869921   EL869924   EL869925   EL871174   EL871175   EL871291   EL871292   EL874202   EL874203   EL883170   EV589376   L80127   L80128   L80129   L80130   L80131   L80132
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VQE0 Q8T9L0 Q8IHG0
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
microtubule associated complex inferred from direct assay (Hughes et al., 2008)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval Malpighian tubules, larval salivary gland, adult testis. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult brain, adult crop, larval/adult midgut, larval/adult hindgut, adult Malpighian tubules, adult heart, larval/adult fat body, adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    509.025 Larval Midgut    465 Larval Hindgut    414.9 Larval Malpighian Tubules    549.3 Larval Fat Body    244.1 Larval Salivary Gland    627.6 Larval Trachea    312.35 Larval Carcass    448.8 Adult Head    278.4 Adult Eye    252.025 Adult Brain    467.2 Adult Thoracic-Abdominal Ganglion    554.3 Adult Crop    430.8 Adult Midgut    445.5 Adult Hindgut    347.7 Adult Malpighian Tubules    385.6 Adult Fat Body    358.4 Adult Salivary Gland    271.5 Adult Heart    373.8 Adult VirginFemale Spermatheca    186.6 Adult InseminatedFemale Spermatheca    172.4 Adult Ovary    465.8 Adult Testis    654.4 Adult Male Accessory Gland    470.7 Adult Carcass    293.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  509.025 Larval Midgut    465 Larval Hindgut    414.9 Larval Malpighian Tubules  (549.3) Larval Fat Body    244.1 Larval Salivary Gland  (627.6) Larval Trachea    312.35 Larval Carcass    448.8 Adult Head    278.4 Adult Eye    252.025 Adult Brain    467.2 Adult Thoracic-Abdominal Ganglion  (554.3) Adult Crop    430.8 Adult Midgut    445.5 Adult Hindgut    347.7 Adult Malpighian Tubules    385.6 Adult Fat Body    358.4 Adult Salivary Gland    271.5 Adult Heart    373.8 Adult VirginFemale Spermatheca    186.6 Adult InseminatedFemale Spermatheca    172.4 Adult Ovary    465.8 Adult Testis  (654.4) Adult Male Accessory Gland    470.7 Adult Carcass    293.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    509.025 Larval Midgut    465 Larval Hindgut    414.9 Larval Malpighian Tubules    549.3 Larval Fat Body    244.1 Larval Salivary Gland    627.6 Larval Trachea    312.35 Larval Carcass    448.8 Adult Head    278.4 Adult Eye    252.025 Adult Brain    467.2 Adult Thoracic-Abdominal Ganglion    554.3 Adult Crop    430.8 Adult Midgut    445.5 Adult Hindgut    347.7 Adult Malpighian Tubules    385.6 Adult Fat Body    358.4 Adult Salivary Gland    271.5 Adult Heart    373.8 Adult VirginFemale Spermatheca    186.6 Adult InseminatedFemale Spermatheca    172.4 Adult Ovary    465.8 Adult Testis    654.4 Adult Male Accessory Gland    470.7 Adult Carcass    293.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    509.025 Larval Midgut    465 Larval Hindgut    414.9 Larval Malpighian Tubules    549.3 Larval Fat Body    244.1 Larval Salivary Gland    627.6 Larval Trachea    312.35 Larval Carcass    448.8 Adult Head    278.4 Adult Eye    252.025 Adult Brain    467.2 Adult Thoracic-Abdominal Ganglion    554.3 Adult Crop    430.8 Adult Midgut    445.5 Adult Hindgut    347.7 Adult Malpighian Tubules    385.6 Adult Fat Body    358.4 Adult Salivary Gland    271.5 Adult Heart    373.8 Adult VirginFemale Spermatheca    186.6 Adult InseminatedFemale Spermatheca    172.4 Adult Ovary    465.8 Adult Testis    654.4 Adult Male Accessory Gland    470.7 Adult Carcass    293.2 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    509.025 Larval Midgut    465 Larval Hindgut    414.9 Larval Malpighian Tubules    549.3 Larval Fat Body    244.1 Larval Salivary Gland    627.6 Larval Trachea    312.35 Larval Carcass    448.8 Adult Head    278.4 Adult Eye    252.025 Adult Brain    467.2 Adult Thoracic-Abdominal Ganglion    554.3 Adult Crop    430.8 Adult Midgut    445.5 Adult Hindgut    347.7 Adult Malpighian Tubules    385.6 Adult Fat Body    358.4 Adult Salivary Gland    271.5 Adult Heart    373.8 Adult VirginFemale Spermatheca    186.6 Adult InseminatedFemale Spermatheca    172.4 Adult Ovary    465.8 Adult Testis    654.4 Adult Male Accessory Gland    470.7 Adult Carcass    293.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  509.025 Larval Midgut    465 Larval Hindgut    414.9 Larval Malpighian Tubules  549.3 Larval Fat Body    244.1 Larval Salivary Gland  627.6 Larval Trachea    312.35 Larval Carcass    448.8 Adult Head    278.4 Adult Eye    252.025 Adult Brain    467.2 Adult Thoracic-Abdominal Ganglion  554.3 Adult Crop    430.8 Adult Midgut    445.5 Adult Hindgut    347.7 Adult Malpighian Tubules    385.6 Adult Fat Body    358.4 Adult Salivary Gland    271.5 Adult Heart    373.8 Adult VirginFemale Spermatheca    186.6 Adult InseminatedFemale Spermatheca    172.4 Adult Ovary    465.8 Adult Testis  654.4 Adult Male Accessory Gland    470.7 Adult Carcass    293.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    509.025 Larval Midgut    465 Larval Hindgut    414.9 Larval Malpighian Tubules    549.3 Larval Fat Body    244.1 Larval Salivary Gland    627.6 Larval Trachea    312.35 Larval Carcass    448.8 Adult Head    278.4 Adult Eye    252.025 Adult Brain    467.2 Adult Thoracic-Abdominal Ganglion    554.3 Adult Crop    430.8 Adult Midgut    445.5 Adult Hindgut    347.7 Adult Malpighian Tubules    385.6 Adult Fat Body    358.4 Adult Salivary Gland    271.5 Adult Heart    373.8 Adult VirginFemale Spermatheca    186.6 Adult InseminatedFemale Spermatheca    172.4 Adult Ovary    465.8 Adult Testis    654.4 Adult Male Accessory Gland    470.7 Adult Carcass    293.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    509.025 Larval Midgut    465 Larval Hindgut    414.9 Larval Malpighian Tubules    549.3 Larval Fat Body    244.1 Larval Salivary Gland    627.6 Larval Trachea    312.35 Larval Carcass    448.8 Adult Head    278.4 Adult Eye    252.025 Adult Brain    467.2 Adult Thoracic-Abdominal Ganglion    554.3 Adult Crop    430.8 Adult Midgut    445.5 Adult Hindgut    347.7 Adult Malpighian Tubules    385.6 Adult Fat Body    358.4 Adult Salivary Gland    271.5 Adult Heart    373.8 Adult VirginFemale Spermatheca    186.6 Adult InseminatedFemale Spermatheca    172.4 Adult Ovary    465.8 Adult Testis    654.4 Adult Male Accessory Gland    470.7 Adult Carcass    293.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    278.4   NA  Eye    252.025   NA  Brain    467.2   509.025  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    554.3   NA  Crop    430.8   465  Midgut    445.5   414.9  Hindgut    347.7   549.3  Malpighian Tubules    385.6   244.1  Fat Body    358.4   627.6  Salivary Gland    271.5   NA  Heart    373.8   312.35  Trachea    NA   NA  VirginFemale Spermatheca    186.6   NA  InseminatedFemale Spermatheca    172.4   NA  Ovary    465.8   NA  Testis    654.4   NA  Male Accessory Gland    470.7   448.8  Carcass    293.2 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    83 central nervous system, larvae L3    44 central nervous system, pupae P8    46 head, virgin 1-day female    22 head, virgin 4-day female    20 head, virgin 20-day female    24 head, mated 1-day female    20 head, mated 4-day female    18 head, mated 20-day female    22 head, mated 1-day male    35 head, mated 4-day male    27 head, mated 20-day male    34 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    8 digestive system, larvae L3 wandering    22 digestive system, 1-day adult    32 digestive system, 4-day adult    29 digestive system, 20-day adult    38 fat body, larvae L3 wandering    10 fat body, white prepupae    21 fat body, pupae P8    38 carcass, larvae L3 wandering    31 carcass, 1-day adult    18 carcass, 4-day adult    21 carcass, 20-day adult    26 ovary, virgin 4-day female    75 ovary, mated 4-day female    65 testis, mated 4-day male    107 accessory gland, mated 4-day male    37 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (83) central nervous system, larvae L3  (44) central nervous system, pupae P8  (46) head, virgin 1-day female    22 head, virgin 4-day female    20 head, virgin 20-day female    24 head, mated 1-day female    20 head, mated 4-day female    18 head, mated 20-day female    22 head, mated 1-day male  (35) head, mated 4-day male  (27) head, mated 20-day male  (34) salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    8 digestive system, larvae L3 wandering    22 digestive system, 1-day adult  (32) digestive system, 4-day adult  (29) digestive system, 20-day adult  (38) fat body, larvae L3 wandering    10 fat body, white prepupae    21 fat body, pupae P8  (38) carcass, larvae L3 wandering  (31) carcass, 1-day adult    18 carcass, 4-day adult    21 carcass, 20-day adult  26 ovary, virgin 4-day female  (75) ovary, mated 4-day female  (65) testis, mated 4-day male  (107) accessory gland, mated 4-day male  (37) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    83 central nervous system, larvae L3    44 central nervous system, pupae P8    46 head, virgin 1-day female    22 head, virgin 4-day female    20 head, virgin 20-day female    24 head, mated 1-day female    20 head, mated 4-day female    18 head, mated 20-day female    22 head, mated 1-day male    35 head, mated 4-day male    27 head, mated 20-day male    34 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    8 digestive system, larvae L3 wandering    22 digestive system, 1-day adult    32 digestive system, 4-day adult    29 digestive system, 20-day adult    38 fat body, larvae L3 wandering    10 fat body, white prepupae    21 fat body, pupae P8    38 carcass, larvae L3 wandering    31 carcass, 1-day adult    18 carcass, 4-day adult    21 carcass, 20-day adult    26 ovary, virgin 4-day female    75 ovary, mated 4-day female    65 testis, mated 4-day male  107 accessory gland, mated 4-day male    37 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    83 central nervous system, larvae L3    44 central nervous system, pupae P8    46 head, virgin 1-day female    22 head, virgin 4-day female    20 head, virgin 20-day female    24 head, mated 1-day female    20 head, mated 4-day female    18 head, mated 20-day female    22 head, mated 1-day male    35 head, mated 4-day male    27 head, mated 20-day male    34 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    8 digestive system, larvae L3 wandering    22 digestive system, 1-day adult    32 digestive system, 4-day adult    29 digestive system, 20-day adult    38 fat body, larvae L3 wandering    10 fat body, white prepupae    21 fat body, pupae P8    38 carcass, larvae L3 wandering    31 carcass, 1-day adult    18 carcass, 4-day adult    21 carcass, 20-day adult    26 ovary, virgin 4-day female    75 ovary, mated 4-day female    65 testis, mated 4-day male    107 accessory gland, mated 4-day male    37 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    83 central nervous system, larvae L3    44 central nervous system, pupae P8    46 head, virgin 1-day female    22 head, virgin 4-day female    20 head, virgin 20-day female    24 head, mated 1-day female    20 head, mated 4-day female    18 head, mated 20-day female    22 head, mated 1-day male    35 head, mated 4-day male    27 head, mated 20-day male    34 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    8 digestive system, larvae L3 wandering    22 digestive system, 1-day adult    32 digestive system, 4-day adult    29 digestive system, 20-day adult    38 fat body, larvae L3 wandering    10 fat body, white prepupae    21 fat body, pupae P8    38 carcass, larvae L3 wandering    31 carcass, 1-day adult    18 carcass, 4-day adult    21 carcass, 20-day adult    26 ovary, virgin 4-day female    75 ovary, mated 4-day female    65 testis, mated 4-day male    107 accessory gland, mated 4-day male    37 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (83) central nervous system, larvae L3  (44) central nervous system, pupae P8  (46) head, virgin 1-day female    22 head, virgin 4-day female    20 head, virgin 20-day female    24 head, mated 1-day female    20 head, mated 4-day female    18 head, mated 20-day female    22 head, mated 1-day male  (35) head, mated 4-day male  27 head, mated 20-day male  (34) salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    8 digestive system, larvae L3 wandering    22 digestive system, 1-day adult  32 digestive system, 4-day adult  29 digestive system, 20-day adult  (38) fat body, larvae L3 wandering    10 fat body, white prepupae    21 fat body, pupae P8  (38) carcass, larvae L3 wandering  31 carcass, 1-day adult    18 carcass, 4-day adult    21 carcass, 20-day adult  26 ovary, virgin 4-day female  (75) ovary, mated 4-day female  (65) testis, mated 4-day male  (107) accessory gland, mated 4-day male  (37) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    83 central nervous system, larvae L3    44 central nervous system, pupae P8    46 head, virgin 1-day female    22 head, virgin 4-day female    20 head, virgin 20-day female    24 head, mated 1-day female    20 head, mated 4-day female    18 head, mated 20-day female    22 head, mated 1-day male    35 head, mated 4-day male    27 head, mated 20-day male    34 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    8 digestive system, larvae L3 wandering    22 digestive system, 1-day adult    32 digestive system, 4-day adult    29 digestive system, 20-day adult    38 fat body, larvae L3 wandering    10 fat body, white prepupae    21 fat body, pupae P8    38 carcass, larvae L3 wandering    31 carcass, 1-day adult    18 carcass, 4-day adult    21 carcass, 20-day adult    26 ovary, virgin 4-day female    75 ovary, mated 4-day female    65 testis, mated 4-day male  107 accessory gland, mated 4-day male    37 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    83 central nervous system, larvae L3    44 central nervous system, pupae P8    46 head, virgin 1-day female    22 head, virgin 4-day female    20 head, virgin 20-day female    24 head, mated 1-day female    20 head, mated 4-day female    18 head, mated 20-day female    22 head, mated 1-day male    35 head, mated 4-day male    27 head, mated 20-day male    34 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    8 digestive system, larvae L3 wandering    22 digestive system, 1-day adult    32 digestive system, 4-day adult    29 digestive system, 20-day adult    38 fat body, larvae L3 wandering    10 fat body, white prepupae    21 fat body, pupae P8    38 carcass, larvae L3 wandering    31 carcass, 1-day adult    18 carcass, 4-day adult    21 carcass, 20-day adult    26 ovary, virgin 4-day female    75 ovary, mated 4-day female    65 testis, mated 4-day male    107 accessory gland, mated 4-day male    37 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages, at stages throughout the pupal period, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    80 embryo 02-04hr    15 embryo 04-06hr    39 embryo 06-08hr    53 embryo 08-10hr    45 embryo 10-12hr    40 embryo 12-14hr    30 embryo 14-16hr    33 embryo 16-18hr    26 embryo 18-20hr    20 embryo 20-22hr    15 embryo 22-24hr    16 larva L1    34 larva L2    39 larva L3 12hr old    36 larva L3 puffstage 1-2    26 larva L3 puffstage 3-6    35 larva L3 puffstage 7-9    38 white prepupae new    39 white prepupae 12hr    46 white prepupae 24hr    59 pupae 2d postWPP    60 pupae 3d postWPP    51 pupae 4d postWPP    35 adult male 01day    54 adult male 05day    69 adult male 30day    70 adult female 01day    53 adult female 05day    65 adult female 30day    66 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (80) embryo 02-04hr    15 embryo 04-06hr  (39) embryo 06-08hr  (53) embryo 08-10hr  (45) embryo 10-12hr  (40) embryo 12-14hr  (30) embryo 14-16hr  (33) embryo 16-18hr  26 embryo 18-20hr    20 embryo 20-22hr    15 embryo 22-24hr    16 larva L1  (34) larva L2  (39) larva L3 12hr old  (36) larva L3 puffstage 1-2  26 larva L3 puffstage 3-6  (35) larva L3 puffstage 7-9  (38) white prepupae new  (39) white prepupae 12hr  (46) white prepupae 24hr  (59) pupae 2d postWPP  (60) pupae 3d postWPP  (51) pupae 4d postWPP  (35) adult male 01day  (54) adult male 05day  (69) adult male 30day  (70) adult female 01day  (53) adult female 05day  (65) adult female 30day  (66) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    80 embryo 02-04hr    15 embryo 04-06hr    39 embryo 06-08hr    53 embryo 08-10hr    45 embryo 10-12hr    40 embryo 12-14hr    30 embryo 14-16hr    33 embryo 16-18hr    26 embryo 18-20hr    20 embryo 20-22hr    15 embryo 22-24hr    16 larva L1    34 larva L2    39 larva L3 12hr old    36 larva L3 puffstage 1-2    26 larva L3 puffstage 3-6    35 larva L3 puffstage 7-9    38 white prepupae new    39 white prepupae 12hr    46 white prepupae 24hr    59 pupae 2d postWPP    60 pupae 3d postWPP    51 pupae 4d postWPP    35 adult male 01day    54 adult male 05day    69 adult male 30day    70 adult female 01day    53 adult female 05day    65 adult female 30day    66 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    80 embryo 02-04hr    15 embryo 04-06hr    39 embryo 06-08hr    53 embryo 08-10hr    45 embryo 10-12hr    40 embryo 12-14hr    30 embryo 14-16hr    33 embryo 16-18hr    26 embryo 18-20hr    20 embryo 20-22hr    15 embryo 22-24hr    16 larva L1    34 larva L2    39 larva L3 12hr old    36 larva L3 puffstage 1-2    26 larva L3 puffstage 3-6    35 larva L3 puffstage 7-9    38 white prepupae new    39 white prepupae 12hr    46 white prepupae 24hr    59 pupae 2d postWPP    60 pupae 3d postWPP    51 pupae 4d postWPP    35 adult male 01day    54 adult male 05day    69 adult male 30day    70 adult female 01day    53 adult female 05day    65 adult female 30day    66 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    80 embryo 02-04hr    15 embryo 04-06hr    39 embryo 06-08hr    53 embryo 08-10hr    45 embryo 10-12hr    40 embryo 12-14hr    30 embryo 14-16hr    33 embryo 16-18hr    26 embryo 18-20hr    20 embryo 20-22hr    15 embryo 22-24hr    16 larva L1    34 larva L2    39 larva L3 12hr old    36 larva L3 puffstage 1-2    26 larva L3 puffstage 3-6    35 larva L3 puffstage 7-9    38 white prepupae new    39 white prepupae 12hr    46 white prepupae 24hr    59 pupae 2d postWPP    60 pupae 3d postWPP    51 pupae 4d postWPP    35 adult male 01day    54 adult male 05day    69 adult male 30day    70 adult female 01day    53 adult female 05day    65 adult female 30day    66 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (80) embryo 02-04hr    15 embryo 04-06hr  (39) embryo 06-08hr  (53) embryo 08-10hr  (45) embryo 10-12hr  (40) embryo 12-14hr  30 embryo 14-16hr  (33) embryo 16-18hr  26 embryo 18-20hr    20 embryo 20-22hr    15 embryo 22-24hr    16 larva L1  (34) larva L2  (39) larva L3 12hr old  (36) larva L3 puffstage 1-2  26 larva L3 puffstage 3-6  (35) larva L3 puffstage 7-9  (38) white prepupae new  (39) white prepupae 12hr  (46) white prepupae 24hr  (59) pupae 2d postWPP  (60) pupae 3d postWPP  (51) pupae 4d postWPP  (35) adult male 01day  (54) adult male 05day  (69) adult male 30day  (70) adult female 01day  (53) adult female 05day  (65) adult female 30day  (66) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    80 embryo 02-04hr    15 embryo 04-06hr    39 embryo 06-08hr    53 embryo 08-10hr    45 embryo 10-12hr    40 embryo 12-14hr    30 embryo 14-16hr    33 embryo 16-18hr    26 embryo 18-20hr    20 embryo 20-22hr    15 embryo 22-24hr    16 larva L1    34 larva L2    39 larva L3 12hr old    36 larva L3 puffstage 1-2    26 larva L3 puffstage 3-6    35 larva L3 puffstage 7-9    38 white prepupae new    39 white prepupae 12hr    46 white prepupae 24hr    59 pupae 2d postWPP    60 pupae 3d postWPP    51 pupae 4d postWPP    35 adult male 01day    54 adult male 05day    69 adult male 30day    70 adult female 01day    53 adult female 05day    65 adult female 30day    66 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    80 embryo 02-04hr    15 embryo 04-06hr    39 embryo 06-08hr    53 embryo 08-10hr    45 embryo 10-12hr    40 embryo 12-14hr    30 embryo 14-16hr    33 embryo 16-18hr    26 embryo 18-20hr    20 embryo 20-22hr    15 embryo 22-24hr    16 larva L1    34 larva L2    39 larva L3 12hr old    36 larva L3 puffstage 1-2    26 larva L3 puffstage 3-6    35 larva L3 puffstage 7-9    38 white prepupae new    39 white prepupae 12hr    46 white prepupae 24hr    59 pupae 2d postWPP    60 pupae 3d postWPP    51 pupae 4d postWPP    35 adult male 01day    54 adult male 05day    69 adult male 30day    70 adult female 01day    53 adult female 05day    65 adult female 30day    66 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    53 Schneider line 2 Sg4    36 embryonic 1182-4H    67 embryonic GM2    42 embryonic Kc167    35 embryonic S1    83 embryonic S3    39 leg disc CME L1    41 wing disc CME-W2    28 wing disc ML-DmD8    38 wing disc ML-DmD9    64 wing disc ML-DmD16-c3    40 wing disc ML-DmD21    44 wing disc ML-DmD32    39 haltere disc ML-DmD17-c3    49 eye-antennal disc ML-DmD11    67 antennal disc ML-DmD20-c5    43 mixed discs ML-DmD4-c1    36 CNS ML-DmBG1-c1    55 CNS ML-DmBG2-c2    28 tumorous blood cells mbn2    36 ovary fGS/OSS    72 ovary OSC    66 ovary OSS    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (53) Schneider line 2 Sg4  (36) embryonic 1182-4H  (67) embryonic GM2  (42) embryonic Kc167  (35) embryonic S1  (83) embryonic S3  (39) leg disc CME L1  (41) wing disc CME-W2  (28) wing disc ML-DmD8  (38) wing disc ML-DmD9  (64) wing disc ML-DmD16-c3  (40) wing disc ML-DmD21  (44) wing disc ML-DmD32  (39) haltere disc ML-DmD17-c3  (49) eye-antennal disc ML-DmD11  (67) antennal disc ML-DmD20-c5  (43) mixed discs ML-DmD4-c1  (36) CNS ML-DmBG1-c1  (55) CNS ML-DmBG2-c2  (28) tumorous blood cells mbn2  (36) ovary fGS/OSS  (72) ovary OSC  (66) ovary OSS    23 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    53 Schneider line 2 Sg4    36 embryonic 1182-4H    67 embryonic GM2    42 embryonic Kc167    35 embryonic S1    83 embryonic S3    39 leg disc CME L1    41 wing disc CME-W2    28 wing disc ML-DmD8    38 wing disc ML-DmD9    64 wing disc ML-DmD16-c3    40 wing disc ML-DmD21    44 wing disc ML-DmD32    39 haltere disc ML-DmD17-c3    49 eye-antennal disc ML-DmD11    67 antennal disc ML-DmD20-c5    43 mixed discs ML-DmD4-c1    36 CNS ML-DmBG1-c1    55 CNS ML-DmBG2-c2    28 tumorous blood cells mbn2    36 ovary fGS/OSS    72 ovary OSC    66 ovary OSS    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    53 Schneider line 2 Sg4    36 embryonic 1182-4H    67 embryonic GM2    42 embryonic Kc167    35 embryonic S1    83 embryonic S3    39 leg disc CME L1    41 wing disc CME-W2    28 wing disc ML-DmD8    38 wing disc ML-DmD9    64 wing disc ML-DmD16-c3    40 wing disc ML-DmD21    44 wing disc ML-DmD32    39 haltere disc ML-DmD17-c3    49 eye-antennal disc ML-DmD11    67 antennal disc ML-DmD20-c5    43 mixed discs ML-DmD4-c1    36 CNS ML-DmBG1-c1    55 CNS ML-DmBG2-c2    28 tumorous blood cells mbn2    36 ovary fGS/OSS    72 ovary OSC    66 ovary OSS    23 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    53 Schneider line 2 Sg4    36 embryonic 1182-4H    67 embryonic GM2    42 embryonic Kc167    35 embryonic S1    83 embryonic S3    39 leg disc CME L1    41 wing disc CME-W2    28 wing disc ML-DmD8    38 wing disc ML-DmD9    64 wing disc ML-DmD16-c3    40 wing disc ML-DmD21    44 wing disc ML-DmD32    39 haltere disc ML-DmD17-c3    49 eye-antennal disc ML-DmD11    67 antennal disc ML-DmD20-c5    43 mixed discs ML-DmD4-c1    36 CNS ML-DmBG1-c1    55 CNS ML-DmBG2-c2    28 tumorous blood cells mbn2    36 ovary fGS/OSS    72 ovary OSC    66 ovary OSS    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (53) Schneider line 2 Sg4  (36) embryonic 1182-4H  (67) embryonic GM2  (42) embryonic Kc167  (35) embryonic S1  (83) embryonic S3  (39) leg disc CME L1  (41) wing disc CME-W2  28 wing disc ML-DmD8  (38) wing disc ML-DmD9  (64) wing disc ML-DmD16-c3  (40) wing disc ML-DmD21  (44) wing disc ML-DmD32  (39) haltere disc ML-DmD17-c3  (49) eye-antennal disc ML-DmD11  (67) antennal disc ML-DmD20-c5  (43) mixed discs ML-DmD4-c1  (36) CNS ML-DmBG1-c1  (55) CNS ML-DmBG2-c2  28 tumorous blood cells mbn2  (36) ovary fGS/OSS  (72) ovary OSC  (66) ovary OSS    23 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    53 Schneider line 2 Sg4    36 embryonic 1182-4H    67 embryonic GM2    42 embryonic Kc167    35 embryonic S1    83 embryonic S3    39 leg disc CME L1    41 wing disc CME-W2    28 wing disc ML-DmD8    38 wing disc ML-DmD9    64 wing disc ML-DmD16-c3    40 wing disc ML-DmD21    44 wing disc ML-DmD32    39 haltere disc ML-DmD17-c3    49 eye-antennal disc ML-DmD11    67 antennal disc ML-DmD20-c5    43 mixed discs ML-DmD4-c1    36 CNS ML-DmBG1-c1    55 CNS ML-DmBG2-c2    28 tumorous blood cells mbn2    36 ovary fGS/OSS    72 ovary OSC    66 ovary OSS    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    53 Schneider line 2 Sg4    36 embryonic 1182-4H    67 embryonic GM2    42 embryonic Kc167    35 embryonic S1    83 embryonic S3    39 leg disc CME L1    41 wing disc CME-W2    28 wing disc ML-DmD8    38 wing disc ML-DmD9    64 wing disc ML-DmD16-c3    40 wing disc ML-DmD21    44 wing disc ML-DmD32    39 haltere disc ML-DmD17-c3    49 eye-antennal disc ML-DmD11    67 antennal disc ML-DmD20-c5    43 mixed discs ML-DmD4-c1    36 CNS ML-DmBG1-c1    55 CNS ML-DmBG2-c2    28 tumorous blood cells mbn2    36 ovary fGS/OSS    72 ovary OSC    66 ovary OSS    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    34 cold shock, 4-day adult    20 heat shock, 4-day adult    40 Cadmium 50 mM 6 hrs, larvae L3    30 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult    39 Cadmium 100 mM 48 hrs, 4-day adult    52 Copper 0.5 mM 12 hrs, larvae L3    19 Copper 15 mM 48 hrs, 4-day adult    20 Zinc 5 mM 12 hrs, larvae L3    22 Zinc 4.5 mM 48 hrs, 4-day adult    21 Ethanol 2.5% 3 hrs, larvae L3    75 Ethanol 5% 3 hrs, larvae L3    30 Ethanol 10% 3 hrs, larvae L3    28 Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    44 Caffeine 25 mg/ml 48 hrs, 4-day adult    25 Paraquat 5 mM 48 hrs, 4-day adult    51 Paraquat 10 mM 48 hrs, 4-day adult    75 Rotenone 2 μg 12 hrs, larvae L3    24 Rotenone 8 μg 12 hrs, larvae L3    33 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (34) cold shock, 4-day adult    20 heat shock, 4-day adult  (40) Cadmium 50 mM 6 hrs, larvae L3  (30) Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult  (39) Cadmium 100 mM 48 hrs, 4-day adult  (52) Copper 0.5 mM 12 hrs, larvae L3    19 Copper 15 mM 48 hrs, 4-day adult    20 Zinc 5 mM 12 hrs, larvae L3    22 Zinc 4.5 mM 48 hrs, 4-day adult    21 Ethanol 2.5% 3 hrs, larvae L3  (75) Ethanol 5% 3 hrs, larvae L3  (30) Ethanol 10% 3 hrs, larvae L3  (28) Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (44) Caffeine 25 mg/ml 48 hrs, 4-day adult    25 Paraquat 5 mM 48 hrs, 4-day adult  (51) Paraquat 10 mM 48 hrs, 4-day adult  (75) Rotenone 2 μg 12 hrs, larvae L3    24 Rotenone 8 μg 12 hrs, larvae L3  (33) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    34 cold shock, 4-day adult    20 heat shock, 4-day adult    40 Cadmium 50 mM 6 hrs, larvae L3    30 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult    39 Cadmium 100 mM 48 hrs, 4-day adult    52 Copper 0.5 mM 12 hrs, larvae L3    19 Copper 15 mM 48 hrs, 4-day adult    20 Zinc 5 mM 12 hrs, larvae L3    22 Zinc 4.5 mM 48 hrs, 4-day adult    21 Ethanol 2.5% 3 hrs, larvae L3    75 Ethanol 5% 3 hrs, larvae L3    30 Ethanol 10% 3 hrs, larvae L3    28 Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    44 Caffeine 25 mg/ml 48 hrs, 4-day adult    25 Paraquat 5 mM 48 hrs, 4-day adult    51 Paraquat 10 mM 48 hrs, 4-day adult    75 Rotenone 2 μg 12 hrs, larvae L3    24 Rotenone 8 μg 12 hrs, larvae L3    33 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    34 cold shock, 4-day adult    20 heat shock, 4-day adult    40 Cadmium 50 mM 6 hrs, larvae L3    30 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult    39 Cadmium 100 mM 48 hrs, 4-day adult    52 Copper 0.5 mM 12 hrs, larvae L3    19 Copper 15 mM 48 hrs, 4-day adult    20 Zinc 5 mM 12 hrs, larvae L3    22 Zinc 4.5 mM 48 hrs, 4-day adult    21 Ethanol 2.5% 3 hrs, larvae L3    75 Ethanol 5% 3 hrs, larvae L3    30 Ethanol 10% 3 hrs, larvae L3    28 Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    44 Caffeine 25 mg/ml 48 hrs, 4-day adult    25 Paraquat 5 mM 48 hrs, 4-day adult    51 Paraquat 10 mM 48 hrs, 4-day adult    75 Rotenone 2 μg 12 hrs, larvae L3    24 Rotenone 8 μg 12 hrs, larvae L3    33 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    34 cold shock, 4-day adult    20 heat shock, 4-day adult    40 Cadmium 50 mM 6 hrs, larvae L3    30 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult    39 Cadmium 100 mM 48 hrs, 4-day adult    52 Copper 0.5 mM 12 hrs, larvae L3    19 Copper 15 mM 48 hrs, 4-day adult    20 Zinc 5 mM 12 hrs, larvae L3    22 Zinc 4.5 mM 48 hrs, 4-day adult    21 Ethanol 2.5% 3 hrs, larvae L3    75 Ethanol 5% 3 hrs, larvae L3    30 Ethanol 10% 3 hrs, larvae L3    28 Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    44 Caffeine 25 mg/ml 48 hrs, 4-day adult    25 Paraquat 5 mM 48 hrs, 4-day adult    51 Paraquat 10 mM 48 hrs, 4-day adult    75 Rotenone 2 μg 12 hrs, larvae L3    24 Rotenone 8 μg 12 hrs, larvae L3    33 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (34) cold shock, 4-day adult    20 heat shock, 4-day adult  (40) Cadmium 50 mM 6 hrs, larvae L3  30 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult  (39) Cadmium 100 mM 48 hrs, 4-day adult  (52) Copper 0.5 mM 12 hrs, larvae L3    19 Copper 15 mM 48 hrs, 4-day adult    20 Zinc 5 mM 12 hrs, larvae L3    22 Zinc 4.5 mM 48 hrs, 4-day adult    21 Ethanol 2.5% 3 hrs, larvae L3  (75) Ethanol 5% 3 hrs, larvae L3  30 Ethanol 10% 3 hrs, larvae L3  28 Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (44) Caffeine 25 mg/ml 48 hrs, 4-day adult    25 Paraquat 5 mM 48 hrs, 4-day adult  (51) Paraquat 10 mM 48 hrs, 4-day adult  (75) Rotenone 2 μg 12 hrs, larvae L3    24 Rotenone 8 μg 12 hrs, larvae L3  (33) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    34 cold shock, 4-day adult    20 heat shock, 4-day adult    40 Cadmium 50 mM 6 hrs, larvae L3    30 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult    39 Cadmium 100 mM 48 hrs, 4-day adult    52 Copper 0.5 mM 12 hrs, larvae L3    19 Copper 15 mM 48 hrs, 4-day adult    20 Zinc 5 mM 12 hrs, larvae L3    22 Zinc 4.5 mM 48 hrs, 4-day adult    21 Ethanol 2.5% 3 hrs, larvae L3    75 Ethanol 5% 3 hrs, larvae L3    30 Ethanol 10% 3 hrs, larvae L3    28 Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    44 Caffeine 25 mg/ml 48 hrs, 4-day adult    25 Paraquat 5 mM 48 hrs, 4-day adult    51 Paraquat 10 mM 48 hrs, 4-day adult    75 Rotenone 2 μg 12 hrs, larvae L3    24 Rotenone 8 μg 12 hrs, larvae L3    33 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    34 cold shock, 4-day adult    20 heat shock, 4-day adult    40 Cadmium 50 mM 6 hrs, larvae L3    30 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult    39 Cadmium 100 mM 48 hrs, 4-day adult    52 Copper 0.5 mM 12 hrs, larvae L3    19 Copper 15 mM 48 hrs, 4-day adult    20 Zinc 5 mM 12 hrs, larvae L3    22 Zinc 4.5 mM 48 hrs, 4-day adult    21 Ethanol 2.5% 3 hrs, larvae L3    75 Ethanol 5% 3 hrs, larvae L3    30 Ethanol 10% 3 hrs, larvae L3    28 Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    44 Caffeine 25 mg/ml 48 hrs, 4-day adult    25 Paraquat 5 mM 48 hrs, 4-day adult    51 Paraquat 10 mM 48 hrs, 4-day adult    75 Rotenone 2 μg 12 hrs, larvae L3    24 Rotenone 8 μg 12 hrs, larvae L3    33 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_21 mE1_20_mRNA_expression_cluster_02
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0026479 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3210-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal Drp1D20 Drp1H22 Drp1H30 Drp1T1 Drp1T9 Drp1T26 lethal (with Drp11) Drp12 lethal (with Drp12) Drp11 lethal | recessive Drp12 viable, with Scer\GAL4pnr-MD237 Drp1GD10456 Other Phenotypes Allele neurophysiology defective Drp11 Drp12 visible, with Scer\GAL4pnr-MD237 Drp1GD10456 Phenotype manifest in Allele autophagic vacuole & larval fat body | somatic clone | cell autonomous Drp1KG03815 embryonic/larval neuromuscular junction Drp12 lysosome & larval fat body | somatic clone | cell autonomous Drp1KG03815 mitochondrial derivative | germline clone Drp1KG03815 mitochondrion Drp1+t9.4 mitochondrion, with Scer\GAL4Mef2.PR Drp1Scer\UAS.cDa mitochondrion (with Drp11) Drp12 mitochondrion (with Drp12) Drp11 mitochondrion & bouton Drp12 mitochondrion & bouton (with Drp11) Drp12 mitochondrion & bouton (with Drp12) Drp11 mitochondrion & larval nervous system Drp12 mitochondrion & larval salivary gland Drp11 Drp12 mitochondrion & motor neuron Drp12 mitochondrion & primary spermatocyte | germ-line clone Drp1KG03815 Nebenkern Drp1βTub85D.PD Nebenkern | germline clone Drp1KG03815 trichogen cell, with Scer\GAL4pnr-MD237 Drp1GD10456 ventral furrow Drp1dsRNA.cGa
Classical Alleles ( 12 )
For All Classical Alleles Show
Allele of Drp1 Class Mutagen Stocks Known lesion Drp1D20 ethyl methanesulfonate 2 -- Drp1KG03815 P-element activity 2 -- Drp11 1 Yes Drp12 1 Yes Drp1f02471 piggyBac transposase 1 -- Drp1T26 ethyl methanesulfonate 1 -- Drp1H12 0 -- Drp1H22 0 -- Drp1H30 0 -- Drp1H7 0 Yes Drp1T1 ethyl methanesulfonate 0 -- Drp1T9 ethyl methanesulfonate 0 --
Alleles Carried on Transgenic Constructs ( 12 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Drp1 Class Mutagen Stocks Known lesion Drp1GD10456 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Drp1JF02762 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Drp1T:Zzzz\FLAG,T:Zzzz\TC,T:Ivir\HA1 in vitro construct - coding region fusion 1 Yes Drp1+t9.4 in vitro construct - genomic fragment 0 Yes Drp1+tCH322-83H15 in vitro construct - genomic fragment 0 Yes Drp1dsRNA.cGa in vitro construct - RNAi 0 Yes Drp1K38A.Scer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Drp1NIG.3210R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Drp1Scer\UAS.cDa in vitro construct - regulatory fusion 0 Yes Drp1Scer\UAS.cDb in vitro construct - regulatory fusion 0 Yes Drp1Scer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Drp1βTub85D.PD in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Not disrupted in	Df(2L)dppd19 (Spencer et al., 1982) Df(2L)dppd21 (Spencer et al., 1982) Df(2L)DTD48 (Gelbart, 1998.10.20)
Disrupted in	Df(2L)C144 (Ly, 2005.3.2, Littleton and Bellen, 1994, McDaniel, 2006.10.11) Df(2L)D20 (Littleton and Bellen, 1994) Df(2L)dppd14 (Ly, 2005.3.2, Bergstrom et al., 1995) Df(2L)dppd19 (Littleton and Bellen, 1994) Df(2L)dpp-H59 (Littleton and Bellen, 1994) Df(2L)DTD2 (Spencer et al., 1982) Df(2L)Exel6008 (Ly, 2005.3.2, Ryder, 2004.4.26, Verstreken et al., 2005) In(2LR)dppd23LDTD21R (Spencer et al., 1982)
Duplicated in	Dp(2;2)dppd13 (Spencer et al., 1982)
Not duplicated in	Dp(2;2)dppd21 (Spencer et al., 1982) Dp(2;2)DTD48 (Spencer et al., 1982)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD10456} NA P{NIG.3210R} NA P{TRiP.JF02762} NA P{UAS-Drp1.D} NA P{UAS-Drp1.Db} NA P{UAS-Drp1.HA} NA P{UAS-Drp1.K38A.HA} NA characterization construct P{Drp1+t9.4} NA P{FLAG-FlAsH-HA-Drp1} NA P{TMR-Drp1.D} NA PBac{CH322-83H15} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{SUPor-P}Drp1KG03815 NA PBac{WH}Drp1f02471 NA
Gene Ontology: Function, Process & Cellular Component ( 11 unique terms )
Terms Based on Experimental Evidence ( 8 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
cytokinesis inferred from mutant phenotype (Echard et al., 2004) intracellular distribution of mitochondria inferred from mutant phenotype (Ly et al., 2005) mitochondrion localization inferred from mutant phenotype (Verstreken et al., 2005) mitochondrion organization inferred from mutant phenotype (Ly et al., 2005, Rival et al., 2011, Deng et al., 2008) positive regulation of mitochondrial fission inferred from mutant phenotype (Ziviani et al., 2010) sperm mitochondrion organization inferred from mutant phenotype (Aldridge et al., 2007) vesicle organization inferred from mutant phenotype (Ly et al., 2005)
Cellular Component
CV term Evidence References
microtubule associated complex inferred from direct assay (Hughes et al., 2008)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
GTPase activity inferred from electronic annotation with InterPro:IPR001401, InterPro:IPR003130 (FlyBase Curators et al., 2004-) GTP binding inferred from electronic annotation with InterPro:IPR000375, InterPro:IPR001401, InterPro:IPR003130 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
synaptic vesicle budding from presynaptic membrane non-traceable author statement (Lloyd et al., 2000)
Cellular Component
CV term Evidence References
microtubule associated complex inferred from sequence or structural similarity (van der Bliek, 1999) inferred from sequence or structural similarity with EMBL:AF019043 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Drp1 - nemy anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Drp1 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 59672 DroID - A comprehensive database of gene and protein interactions. • FBgn0026479 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33445
Orthologs
OrthoDB Orthologs (41) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG666W5D Dipteran inclusive ortholog search EOG6NVZTG Insect inclusive ortholog search EOG6S1S36 Arthropod inclusive ortholog search EOG6PG4G0 Metazoa inclusive ortholog search EOG65QW64
Orthologs in Drosophila Species (EOG666W5D)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Drp1     Drosophila simulans   Dsim\GD22819 Y   Drosophila sechellia   Dsec\GM18211 Y   Drosophila sechellia   Dsec\GM16218     Drosophila erecta   Dere\GG24504 Y   Drosophila yakuba   Dyak\GE15067 Y   Drosophila ananassae   Dana\GF20595 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA16678 Y   Drosophila persimilis   Dper\GL26456 Y   Drosophila willistoni   Dwil\GK24492 Y   Drosophila virilis   Dvir\GJ23546 Y   Drosophila mojavensis   Dmoj\GI23021 Y   Drosophila grimshawi   Dgri\GH10575 Y
Orthologs in non-Drosophila Dipterans (EOG6NVZTG)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL009068   Anopheles gambiae Malaria mosquito  Agam\AGAP008896   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ801961
Orthologs in non-Dipteran Insects (EOG6S1S36)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\Drp1   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG001110   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH14535   Atta cephalotes Leafcutter ant  Acep\ACEP10654   Camponotus floridanus Florida carpenter ant  Cflo\CFLO16961   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL22412   Linepithema humile Argentine ant  Lhum\LH15877   Pogonomyrmex barbatus Red harvester ant  Pbar\PB19873   Solenopsis invicta Red fire ant  Sinv\SINV26227   Acyrthosiphon pisum Pea aphid  Apim\ACYPI007635   Bombyx mori Silkmoth  Bmor\BGIBMGA001165   Pediculus humanus Human body louse  Phum\PHUM080460   Pediculus humanus Human body louse  Phum\PHUM028830   Tribolium castaneum Red flour beetle  Tcas\TC014137
Orthologs in non-Insect Arthropods (EOG6PG4G0)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_309039   Ixodes scapularis Deer tick  Isca\ISCW018476
Orthologs in non-Arthropod Metazoa (EOG65QW64)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\drp-1   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_018802gn   Danio rerio Zebrafish  Drer\si:dkey-32e23.4   Danio rerio Zebrafish  Drer\dnm1l   Xenopus tropicalis Western clawed frog  Xtro\dnm1l   Gallus gallus Domestic chicken  Ggal\DNM1L   Mus musculus House mouse  Mmus\Dnm1l   Rattus norvegicus Norway rat  Rnor\Dnm1l   Homo sapiens Human  Hsap\ENSG00000087470
Human Orthologs (1)
Gene OMIM HGNC Hsap\ENSG00000087470
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD22819 Drosophila sechellia Dsec\GM18211 Drosophila erecta Dere\GG24504 Drosophila yakuba Dyak\GE15067 Drosophila ananassae Dana\GF20595 Drosophila pseudoobscura pseudoobscura Dpse\GA16678 Drosophila persimilis Dper\GL26456 Drosophila willistoni Dwil\GK24492 Drosophila virilis Dvir\GJ23546 Drosophila mojavensis Dmoj\GI23021 Drosophila grimshawi Dgri\GH10575
Stocks & Reagents
Stocks Listed in FlyBase ( 12 )
Bloomington	27682 y1 v1; P{TRiP.JF02762}attP2 42208 y1 w*; P{FLAG-FlAsH-HA-Drp1}3, Ki1 13510 y1; P{SUPor-P}Drp1KG03815/CyO; ry506 3662 Drp1T26 cn1 bw1 sp1/In(2LR)Gla, wgGla-1 3911 Df(2L)D20, Drp1D20 nrdD20 cn1 bw1 sp1/In(2LR)Gla, wgGla-1 24885 yd2 w1118 P{ey-FLP.N}2 P{GMR-lacZ.C(38.1)}TPN1; P{Car20y}25F Drp11 P{neoFRT}40A/CyO, P{GAL4-Kr.C}DC3, P{UAS-GFP.S65T}DC7 24899 yd2 w1118 P{ey-FLP.N}2 P{GMR-lacZ.C(38.1)}TPN1; P{Car20y}25F Drp12 P{neoFRT}40A/CyO, P{GAL4-Kr.C}DC3, P{UAS-GFP.S65T}DC7
Harvard	- PBac{WH}Drp1f02471
Kyoto	107264 Df(2L)D20, Drp1D20 nrdD20 cn1 bw1 sp1/In(2LR)Gla, wgGla-1 111549 yd2 w1118 P{ey-FLP.N}2 P{GMR-lacZ.C(38.1)}TPN1; P{SUPor-P}Drp1KG03815 P{neoFRT}40A/CyO y+
VDRC	v44155 w1118; P{GD10456}v44155/TM3 v44156 w1118; P{GD10456}v44156/TM3
Genomic Clones ( 2 )
	BACR30P05 BACR34M11 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 58 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT04516 GM01975
Other clones	FI19305
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT01652 AT01807 AT02650 AT03757 AT04103 AT07466 AT07831 AT07909 AT07982 AT07985 AT12078 AT14661 AT15440 AT17357 AT17575 AT17791 AT21462 AT22190 AT22941 AT23440 AT24515 AT25331 AT28165 AT28955 AT30366 GH18911 GH19317 GH21449 GH28763 LD42330 LP03713 LP17360 RE08373 RE11272 RE11609 RE36495 RE70780 SD01547 SD07209 SD09275
Other clones	AT12996 Dmel_neb_015160_0439_2450 EC053751 EK240622 EN01954 EP11734 FGM237A08 FGM314E05 IP02057 IP02059 IP03315 IP03415 IP12885 IP14237 LD43296
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0026479 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33445
Antibody Information
	polyclonal (Poole et al., 2010)
Other Information
Discoverer
Etymology
	The gene is named "fratboy" after the mutant phenotype; adult escaper flies are uncoordinated and show numerous neurological defects. (Verstreken et al., 2005)
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: noodle CG3210 (Rikhy, 2004.3.5)
Source for database merge of	Source for merge of: Drp1 dynamin-2 noodle l(2)22Fc l(2)22Fd (Ly, 2005.3.2)
Additional comments	'CG3210', 'Drp1' and 'dynamin-2' may all correspond to the same gene. (Hales, 2002.7.8)
Other Comments
	Drp1 is required for the normal distribution of mitochondria in spermatocytes and the normal unfurling of the mitochondrial derivatives in early spermatids during sperm formation. (Aldridge et al., 2007) Drp1 is required for normal mitochondrial distribution and morphology in all cells tested. (Ly et al., 2005) Mutants show a defect in the formation and recruitment of the synaptic vesicle reserve pool. (Ly et al., 2005) Drp1 is required for the proper cellular distribution of mitochondria. (Verstreken et al., 2005) dsRNA directed against this gene causes defects in cytokinesis when tested in an RNAi screen in S2 cells. (Echard et al., 2004) Required at the neuromuscular junction. (Rikhy et al., 2004) Mutants show a distinct temperature sensitive paralysis phenotype. (Rikhy et al., 2004) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_134850 NM_001273017 RefSeq (Proteins) • NP_608694 NP_001259946 DDBJ / EMBL / GenBank • AA695034 AAF51235 AAL39391 AAN71025 AC002444 AGB92483 AW941162 AY069246 BF495569 BH740812 BT001269 CZ484989 L80127 L80128 L80129 L80130 L80131 L80132 Entrez Gene - A searchable database of RefSeq genes. • 33445 UniProtKB/TrEMBL • Q8IHG0 Q8T9L0 Q9VQE0
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Dynamin central domain (IPR000375) Dynamin, GTPase domain (IPR001401) Dynamin GTPase effector (IPR003130) Dynamin, GTPase region, conserved site (IPR019762) P-loop containing nucleoside triphosphate hydrolase (IPR027417) GTPase effector domain, GED (IPR020850) Dynamin (IPR022812)
Linkouts
	BioGRID - A database of protein and genetic interactions • 59672 DroID - A comprehensive database of gene and protein interactions. • FBgn0026479 DRSC - Results from RNAi screens. • FBgn0026479 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0026479 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3210-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0026479 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33445 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /genebrief/dynaminrp.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33445 modMine - Data generated by the modENCODE project. • FBgn0026479
Synonyms & Secondary IDs ( 26 )
Reported As
Symbol Synonym	CG3210 (Echard et al., 2004, Hales, 2002.7.8, Gong et al., 2004, Verstreken et al., 2005, Perkins et al., 2009, Liebl and Featherstone, 2005, Hughes et al., 2008, Puri et al., 2008, Azad et al., 2012) Dnm1/Drp1 (van der Bliek, 1999) Drp (Venken, 2006, Venken et al., 2006) Drp1 (Aldridge et al., 2007, Rival et al., 2011, Yang et al., 2008, Liu et al., 2011, Venken et al., 2009, Arsham and Neufeld, 2009, Yang et al., 2008, Venken et al., 2009, Engström et al., 2007, Poole et al., 2010, Ziviani et al., 2010, Imai et al., 2010, Vidal et al., 2010, Vrailas-Mortimer et al., 2011, Azad et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Humphrey et al., 2012) Drp-1 (Anonymous, 2007) drp1 (Venken, 2006, Hollenbeck, 2005, Vilain et al., 2012, Chouhan et al., 2010, Rival et al., 2011, Poole et al., 2008, Fernandes and Rao, 2011, Muliyil et al., 2011, Abdelwahid et al., 2007, Verstreken et al., 2005, Park et al., 2009, Deng et al., 2008, Park et al., 2010, Mitra et al., 2012) DRP1 (McBride et al., 2006, Mitra et al., 2012, Duboff et al., 2012) drp-1 (Goyal et al., 2007) frat (Verstreken et al., 2005) l(2)22Fc (Bloomington Drosophila Stock Center, 1998.8.28, ) l(2)22Fd   l(2)ND2 (Bergstrom et al., 1995, Littleton and Bellen, 1994, Spencer et al., 1982, ) l(2)ND3 (Bergstrom et al., 1995, Littleton and Bellen, 1994, Spencer et al., 1982, ) unnamed (Rikhy et al., 2004)
Name Synonym	dynamin-2 (Kjaerulff et al., 2002, Hales, 2002.7.8, Lloyd et al., 2000, ) dynamin-related protein (Verstreken et al., 2005) Dynamin related protein 1 (van der Bliek, 1999, ) dynamin related protein-1 (Chouhan et al., 2010) dynamin-related protein 1 (Mitra et al., 2012) fratboy (Ly et al., 2005, Verstreken et al., 2005) lethal(2)22Fc   lethal(2)22Fd   near dpp complementation group 2 (Spencer et al., 1982) near dpp complementation group 3 (Spencer et al., 1982) noodle (Aldridge and Hales, 2005, Rikhy, 2004.3.5, ) Noodle (Puri et al., 2008)
Secondary FlyBase IDs
	FBgn0005566 FBgn0005579 FBgn0031438 FBgn0042649
References ( 77 )
Generate a list of	All references relating to this gene ( 77 )
List References by type	Research paper  ( 39 ) Supplementary material  ( 9 ) Review  ( 5 ) Erratum  ( 1 ) Personal communication to FlyBase  ( 14 ) Abstract  ( 4 ) FlyBase analysis  ( 1 ) Stock list  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 12 )
	Azad et al., 2012, G3 (Bethesda) 2(10): 1169--1178 Identification of Genes Underlying Hypoxia Tolerance in Drosophila by a P-element Screen. [FBrf0219647] Burman et al., 2012, Proc. Natl. Acad. Sci. U.S.A. 109(26): 10438--10443 Analysis of neural subtypes reveals selective mitochondrial dysfunction in dopaminergic neurons from parkin mutants. [FBrf0218718] Duboff et al., 2012, Neuron 75(4): 618--632 Tau Promotes Neurodegeneration via DRP1 Mislocalization In Vivo. [FBrf0219271] Humphrey et al., 2012, Hum. Mol. Genet. 21(12): 2698--2712 Alternative oxidase rescues mitochondria-mediated dopaminergic cell loss in Drosophila. [FBrf0218424] Mitra et al., 2012, J. Cell Biol. 197(4): 487--497 DRP1-dependent mitochondrial fission initiates follicle cell differentiation during Drosophila oogenesis. [FBrf0218275] Vilain et al., 2012, PLoS Genet. 8(1): e1002456 The Yeast Complex I Equivalent NADH Dehydrogenase Rescues pink1 Mutants. [FBrf0217195] Fernandes and Rao, 2011, Mol. Brain 4(1): 17 Genome-wide screen for modifiers of Parkinson's disease genes in Drosophila. [FBrf0213658] Liu et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(31): 12920--12924 Pink1 regulates the oxidative phosphorylation machinery via mitochondrial fission. [FBrf0214637] Muliyil et al., 2011, Development 138(14): 3043--3054 Spatial, temporal and molecular hierarchies in the link between death, delamination and dorsal closure. [FBrf0215259] Rival et al., 2011, EMBO Rep. 12(3): 223--230 Inner-membrane proteins PMI/TMEM11 regulate mitochondrial morphogenesis independently of the DRP1/MFN fission/fusion pathways. [FBrf0213174] Tanner et al., 2011, Development 138(2): 327--338 Bcl-2 proteins and autophagy regulate mitochondrial dynamics during programmed cell death in the Drosophila ovary. [FBrf0212552] Vrailas-Mortimer et al., 2011, Dev. Cell 21(4): 783--795 A Muscle-Specific p38 MAPK/Mef2/MnSOD Pathway Regulates Stress, Motor Function, and Life Span in Drosophila. [FBrf0216446] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...