General Information
Symbol
Dmel\Drp1
Species
D. melanogaster
Name
Dynamin related protein 1
Annotation Symbol
CG3210
Feature Type
FlyBase ID
FBgn0026479
Gene Model Status
Stock Availability
Gene Snapshot
Dynamin related protein 1 (Drp1) encodes a dynamin-like GTPase that mediates mitochondrial fission through a process that involves translocation to the mitochondrial outer membrane and oligomerization. It is required for normal neuronal development and maintenance of postmitotic neuronal function and viability. [Date last reviewed: 2018-09-27]
Also Known As
l(2)ND3, l(2)ND2, Drp-1, Drp, l(2)22Fc
Genomic Location
Cytogenetic map
Sequence location
2L:2,581,281..2,585,430 [-]
Recombination map
2-7
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
GO Summary Ribbons
Families, Domains and Molecular Function
Gene Group Membership (FlyBase)
Protein Family (UniProt, Sequence Similarities)
-
Molecular Function (see GO section for details)
Experimental Evidence
-
Predictions / Assertions
Summaries
Interactive Fly
a Dynamin GTPase - regulates mitochondrial fission in normal cells including primary spermatocytes - mediates mitochondrial fragmentation during programmed cell death
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\Drp1 or the JBrowse view of Dmel\Drp1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.47
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0077744
2711
735
FBtr0335173
2868
735
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0077424
82.6
735
6.98
FBpp0307166
82.6
735
6.98
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

735 aa isoforms: Drp1-PA, Drp1-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Drp1 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (25 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000170013
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000170013
(assigned by GO_Central )
Biological Process (17 terms)
Terms Based on Experimental Evidence (8 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (10 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN002480309
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000170085
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN002480309
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000170085
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000902162
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN002480309
(assigned by GO_Central )
inferred from electronic annotation with InterPro:IPR030556
(assigned by InterPro )
inferred from biological aspect of ancestor with PANTHER:PTN002480309
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN002480309
(assigned by GO_Central )
Cellular Component (5 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
inferred from direct assay
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000170013
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000170013
(assigned by GO_Central )
inferred from sequence or structural similarity
inferred from biological aspect of ancestor with PANTHER:PTN000170085
(assigned by GO_Central )
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
inferred from direct assay
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Drp1 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 13 )
For All Classical and Insertion Alleles Show
 
Allele of Drp1
Class
Mutagen
Associated Insertion
Stocks
Known lesion
    Yes
      Yes
        0
        Yes
        Other relevant insertions
        Transgenic Constructs ( 18 )
        For All Alleles Carried on Transgenic Constructs Show
        Transgenic constructs containing/affecting coding region of Drp1
        Allele of Drp1
        Mutagen
        Associated Transgenic Construct
        Stocks
        Transgenic constructs containing regulatory region of Drp1
        Deletions and Duplications ( 14 )
        Phenotypes
        For more details about a specific phenotype click on the relevant allele symbol.
        Lethality
        Allele
        Other Phenotypes
        Allele
        Phenotype manifest in
        Allele
        autophagic vacuole & larval fat body | somatic clone | cell autonomous
        lysosome & larval fat body | somatic clone | cell autonomous
        mitochondrion & bouton
        mitochondrion & bouton (with Drp11)
        mitochondrion & bouton (with Drp12)
        mitochondrion & larval nervous system
        mitochondrion & larval salivary gland
        mitochondrion & motor neuron
        mitochondrion & primary spermatocyte | germ-line clone
        Orthologs
        Human Orthologs (via DIOPT v7.1)
        Homo sapiens (Human) (6)
        Species\Gene Symbol
        Score
        Best Score
        Best Reverse Score
        Alignment
        Complementation?
        Transgene?
        14 of 15
        Yes
        Yes
         
         
        3 of 15
        No
        No
        3 of 15
        No
        No
         
        3 of 15
        No
        No
        1 of 15
        No
        Yes
        1 of 15
        No
        Yes
        Model Organism Orthologs (via DIOPT v7.1)
        Mus musculus (laboratory mouse) (4)
        Species\Gene Symbol
        Score
        Best Score
        Best Reverse Score
        Alignment
        Complementation?
        Transgene?
        14 of 15
        Yes
        Yes
        3 of 15
        No
        No
        3 of 15
        No
        No
        3 of 15
        No
        No
        Rattus norvegicus (Norway rat) (6)
        12 of 13
        Yes
        Yes
        2 of 13
        No
        No
        1 of 13
        No
        No
        1 of 13
        No
        No
        1 of 13
        No
        Yes
        1 of 13
        No
        Yes
        Xenopus tropicalis (Western clawed frog) (4)
        8 of 12
        Yes
        Yes
        2 of 12
        No
        No
        2 of 12
        No
        No
        2 of 12
        No
        No
        Danio rerio (Zebrafish) (15)
        13 of 15
        Yes
        Yes
        3 of 15
        No
        No
        3 of 15
        No
        No
        3 of 15
        No
        No
        3 of 15
        No
        No
        1 of 15
        No
        No
        1 of 15
        No
        Yes
        1 of 15
        No
        Yes
        1 of 15
        No
        Yes
        1 of 15
        No
        Yes
        1 of 15
        No
        Yes
        1 of 15
        No
        Yes
        1 of 15
        No
        Yes
        Caenorhabditis elegans (Nematode, roundworm) (2)
        12 of 15
        Yes
        Yes
        3 of 15
        No
        No
        Arabidopsis thaliana (thale-cress) (11)
        6 of 9
        Yes
        Yes
        6 of 9
        Yes
        Yes
        1 of 9
        No
        Yes
        1 of 9
        No
        Yes
        1 of 9
        No
        Yes
        1 of 9
        No
        Yes
        1 of 9
        No
        Yes
        1 of 9
        No
        Yes
        1 of 9
        No
        Yes
        1 of 9
        No
        Yes
        1 of 9
        No
        Yes
        Saccharomyces cerevisiae (Brewer's yeast) (3)
        14 of 15
        Yes
        Yes
        8 of 15
        No
        Yes
        1 of 15
        No
        No
        Schizosaccharomyces pombe (Fission yeast) (2)
        11 of 12
        Yes
        Yes
        7 of 12
        No
        Yes
        Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG0919037C )
        Organism
        Common Name
        Gene
        AAA Syntenic Ortholog
        Multiple Dmel Genes in this Orthologous Group
        Drosophila melanogaster
        fruit fly
        Drosophila suzukii
        Spotted wing Drosophila
        Drosophila simulans
        Drosophila sechellia
        Drosophila sechellia
        Drosophila erecta
        Drosophila yakuba
        Drosophila ananassae
        Drosophila pseudoobscura pseudoobscura
        Drosophila persimilis
        Drosophila willistoni
        Drosophila virilis
        Drosophila mojavensis
        Drosophila grimshawi
        Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091501PZ )
        Organism
        Common Name
        Gene
        Multiple Dmel Genes in this Orthologous Group
        Musca domestica
        House fly
        Glossina morsitans
        Tsetse fly
        Lucilia cuprina
        Australian sheep blowfly
        Mayetiola destructor
        Hessian fly
        Aedes aegypti
        Yellow fever mosquito
        Anopheles darlingi
        American malaria mosquito
        Anopheles gambiae
        Malaria mosquito
        Culex quinquefasciatus
        Southern house mosquito
        Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W01WT )
        Organism
        Common Name
        Gene
        Multiple Dmel Genes in this Orthologous Group
        Bombyx mori
        Silkmoth
        Danaus plexippus
        Monarch butterfly
        Heliconius melpomene
        Postman butterfly
        Apis florea
        Little honeybee
        Apis mellifera
        Western honey bee
        Bombus impatiens
        Common eastern bumble bee
        Bombus terrestris
        Buff-tailed bumblebee
        Linepithema humile
        Argentine ant
        Megachile rotundata
        Alfalfa leafcutting bee
        Nasonia vitripennis
        Parasitic wasp
        Dendroctonus ponderosae
        Mountain pine beetle
        Tribolium castaneum
        Red flour beetle
        Pediculus humanus
        Human body louse
        Pediculus humanus
        Human body louse
        Rhodnius prolixus
        Kissing bug
        Cimex lectularius
        Bed bug
        Cimex lectularius
        Bed bug
        Acyrthosiphon pisum
        Pea aphid
        Zootermopsis nevadensis
        Nevada dampwood termite
        Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X01UE )
        Organism
        Common Name
        Gene
        Multiple Dmel Genes in this Orthologous Group
        Strigamia maritima
        European centipede
        Ixodes scapularis
        Black-legged tick
        Stegodyphus mimosarum
        African social velvet spider
        Tetranychus urticae
        Two-spotted spider mite
        Tetranychus urticae
        Two-spotted spider mite
        Daphnia pulex
        Water flea
        Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G02TQ )
        Organism
        Common Name
        Gene
        Multiple Dmel Genes in this Orthologous Group
        Strongylocentrotus purpuratus
        Purple sea urchin
        Ciona intestinalis
        Vase tunicate
        Gallus gallus
        Domestic chicken
        Human Disease Model Data
        FlyBase Human Disease Model Reports
        Alleles Reported to Model Human Disease (Disease Ontology)
        Download
        Models ( 0 )
        Allele
        Disease
        Evidence
        References
        Interactions ( 8 )
        Comments ( 1 )
         
        Drp1+t9.4 ameliorates the bioenergetic defects seen in the Pink1B9 Parkinson's model.
        Human Orthologs (via DIOPT v7.1)
        Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Dmel gene
        Ortholog showing functional complementation
        Supporting References
        Interactions
        Summary of Physical Interactions
        esyN Network Diagram
        Show neighbor-neighbor interactions:
        Select Layout:
        Legend:
        Protein
        RNA
        Selected Interactor(s)
        Interactions Browser

        Please look at the Interaction Group reports for full details of the physical interactions
        protein-protein
        Interacting group
        Assay
        References
        Summary of Genetic Interactions
        esyN Network Diagram
        esyN Network Key:
        Suppression
        Enhancement

        Please look at the allele data for full details of the genetic interactions
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        suppressible
        External Data
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        Pathways
        Gene Group - Pathway Membership (FlyBase)
        External Data
        Linkouts
        KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        2L
        Recombination map
        2-7
        Cytogenetic map
        Sequence location
        2L:2,581,281..2,585,430 [-]
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        23A1-23A1
        Limits computationally determined from genome sequence between P{PZ}dpp10638 and P{EP}EP832
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        Determined by comparing Celera genomic sequence with sequence from BDGP BAC and P1 clones.
        Experimentally Determined Recombination Data
        Location
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (17)
        Genomic Clones (13)
         

        Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

        cDNA Clones (58)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequences
        BDGP DGC clones
        Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        Antibody Information
        Laboratory Generated Antibodies
         
        polyclonal
        Commercially Available Antibodies
         
        Other Information
        Relationship to Other Genes
        Source for database identify of
        Source for identity of: noodle CG3210
        Source for database merge of
        Source for merge of: Drp1 dynamin-2 noodle l(2)22Fc l(2)22Fd
        Additional comments
        'CG3210', 'Drp1' and 'dynamin-2' may all correspond to the same gene.
        Other Comments
        Drp1 is required for the normal distribution of mitochondria in spermatocytes and the normal unfurling of the mitochondrial derivatives in early spermatids during sperm formation.
        Drp1 is required for normal mitochondrial distribution and morphology in all cells tested.
        Mutants show a defect in the formation and recruitment of the synaptic vesicle reserve pool.
        Drp1 is required for the proper cellular distribution of mitochondria.
        dsRNA directed against this gene causes defects in cytokinesis when tested in an RNAi screen in S2 cells.
        Required at the neuromuscular junction.
        Mutants show a distinct temperature sensitive paralysis phenotype.
        dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
        Origin and Etymology
        Discoverer
        Etymology
        The gene is named "fratboy" after the mutant phenotype; adult escaper flies are uncoordinated and show numerous neurological defects.
        Identification
        External Crossreferences and Linkouts ( 57 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center cDNA clones
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        Flygut - An atlas of the Drosophila adult midgut
        FlyMine - An integrated database for Drosophila genomics
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
        Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        KEGG Genes - Molecular building blocks of life in the genomic space.
        KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
        MIST (genetic) - An integrated Molecular Interaction Database
        MIST (protein-protein) - An integrated Molecular Interaction Database
        modMine - A data warehouse for the modENCODE project
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Synonyms and Secondary IDs (30)
        Reported As
        Symbol Synonym
        l(2)22Fd
        Name Synonyms
        Dynamin Related Protein 1
        Dynamin related protein 1
        dynamin related protein-1
        dynamin-related protein
        dynamin-related protein 1
        dynaminrelated protein 1
        lethal(2)22Fc
        lethal(2)22Fd
        near dpp complementation group 2
        near dpp complementation group 3
        Secondary FlyBase IDs
        • FBgn0005566
        • FBgn0005579
        • FBgn0031438
        • FBgn0042649
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        References (152)