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General Information
Symbol
Dmel\Drp1
Species
D. melanogaster
Name
Dynamin related protein 1
Annotation Symbol
CG3210
Feature Type
FlyBase ID
FBgn0026479
Gene Model Status
Stock Availability
Gene Snapshot
Dynamin related protein 1 (Drp1) encodes a dynamin-like GTPase that mediates mitochondrial fission through a process that involves translocation to the mitochondrial outer membrane and oligomerization. It is required for normal neuronal development and maintenance of postmitotic neuronal function and viability. [Date last reviewed: 2018-09-27]
Also Known As

l(2)ND3, l(2)ND2, dynamin-2, noodle, Drp-1

Key Links
Genomic Location
Cytogenetic map
Sequence location
2L:2,581,281..2,585,430 [-]
Recombination map

2-7

RefSeq locus
NT_033779 REGION:2581281..2585430
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (23 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000170013
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000170013
(assigned by GO_Central )
Biological Process (16 terms)
Terms Based on Experimental Evidence (8 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (8 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN002480309
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN002480309
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN002480309
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000170013
(assigned by GO_Central )
inferred from electronic annotation with InterPro:IPR030556
(assigned by InterPro )
inferred from biological aspect of ancestor with PANTHER:PTN002480309
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN002480309
(assigned by GO_Central )
Cellular Component (4 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
inferred from direct assay
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000170013
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000170013
(assigned by GO_Central )
inferred from sequence or structural similarity
Protein Family (UniProt)
-
Summaries
Summary (Interactive Fly)
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\Drp1 or the JBrowse view of Dmel\Drp1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.47

Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0077744
2711
735
FBtr0335173
2868
735
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0077424
82.6
735
6.98
FBpp0307166
82.6
735
6.98
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

735 aa isoforms: Drp1-PA, Drp1-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Drp1 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
inferred from direct assay
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Drp1 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 16 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 20 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Drp1
Transgenic constructs containing regulatory region of Drp1
Deletions and Duplications ( 14 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
autophagic vacuole & larval fat body | somatic clone | cell autonomous
lysosome & larval fat body | somatic clone | cell autonomous
mitochondrion & bouton
mitochondrion & bouton (with Drp11)
mitochondrion & bouton (with Drp12)
mitochondrion & larval nervous system
mitochondrion & larval salivary gland
mitochondrion & motor neuron
mitochondrion & primary spermatocyte | germ-line clone
Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (9)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
14 of 15
Yes
Yes
 
6  
3 of 15
No
No
3 of 15
No
No
5  
3 of 15
No
No
1 of 15
No
No
2  
1 of 15
No
No
5  
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (8)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
14 of 15
Yes
Yes
3 of 15
No
No
3 of 15
No
No
3 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Rattus norvegicus (Norway rat) (9)
12 of 13
Yes
Yes
2 of 13
No
No
2 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (7)
10 of 12
Yes
Yes
2 of 12
No
No
2 of 12
No
No
2 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
Danio rerio (Zebrafish) (21)
13 of 15
Yes
Yes
10 of 15
No
Yes
3 of 15
No
No
3 of 15
No
No
3 of 15
No
No
3 of 15
No
No
2 of 15
No
Yes
2 of 15
No
Yes
2 of 15
No
Yes
2 of 15
No
Yes
2 of 15
No
Yes
2 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (4)
13 of 15
Yes
Yes
3 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (11)
6 of 9
Yes
Yes
6 of 9
Yes
Yes
2 of 9
No
Yes
2 of 9
No
Yes
2 of 9
No
Yes
2 of 9
No
Yes
2 of 9
No
Yes
1 of 9
No
Yes
1 of 9
No
No
1 of 9
No
Yes
1 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (4)
13 of 15
Yes
Yes
8 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (2)
10 of 12
Yes
Yes
7 of 12
No
Yes
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG0919037C )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091501PZ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W01WT )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X01UE )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G02TQ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Ciona intestinalis
Vase tunicate
Gallus gallus
Domestic chicken
Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (4)
5 of 10
3 of 10
1 of 10
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Potential Models Based on Orthology ( 2 )
Modifiers Based on Experimental Evidence ( 8 )
Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Dmel gene
Ortholog showing functional complementation
Supporting References
Interactions
Summary of Physical Interactions
esyN Network Diagram
Show neighbor-neighbor interactions:
Select Layout:
Legend:
Protein
RNA
Selected Interactor(s)
Interactions Browser

Please see the Physical Interaction reports below for full details
protein-protein
Physical Interaction
Assay
References
Summary of Genetic Interactions
esyN Network Diagram
esyN Network Key:
Suppression
Enhancement

Please look at the allele data for full details of the genetic interactions
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
suppressible
External Data
Linkouts
BioGRID - A database of protein and genetic interactions.
DroID - A comprehensive database of gene and protein interactions.
InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
Pathways
Signaling Pathways (FlyBase)
Metabolic Pathways
External Data
Linkouts
KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
Genomic Location and Detailed Mapping Data
Chromosome (arm)
2L
Recombination map

2-7

Cytogenetic map
Sequence location
2L:2,581,281..2,585,430 [-]
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
23A1-23A1
Limits computationally determined from genome sequence between P{PZ}dpp10638 and P{EP}EP832
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
Determined by comparing Celera genomic sequence with sequence from BDGP BAC and P1 clones.
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Stocks and Reagents
Stocks (18)
Genomic Clones (13)
 

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (58)
 

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced
BDGP DGC clones
Other clones
Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)
RNAi and Array Information
Linkouts
DRSC - Results frm RNAi screens
GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
Antibody Information
Laboratory Generated Antibodies
Commercially Available Antibodies
 
Other Information
Relationship to Other Genes
Source for database identify of

Source for identity of: noodle CG3210

Source for database merge of

Source for merge of: Drp1 dynamin-2 noodle l(2)22Fc l(2)22Fd

Additional comments

'CG3210', 'Drp1' and 'dynamin-2' may all correspond to the same gene.

Other Comments

Drp1 is required for the normal distribution of mitochondria in spermatocytes and the normal unfurling of the mitochondrial derivatives in early spermatids during sperm formation.

Drp1 is required for normal mitochondrial distribution and morphology in all cells tested.

Mutants show a defect in the formation and recruitment of the synaptic vesicle reserve pool.

Drp1 is required for the proper cellular distribution of mitochondria.

dsRNA directed against this gene causes defects in cytokinesis when tested in an RNAi screen in S2 cells.

Required at the neuromuscular junction.

Mutants show a distinct temperature sensitive paralysis phenotype.

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

Origin and Etymology
Discoverer
Etymology

The gene is named "fratboy" after the mutant phenotype; adult escaper flies are uncoordinated and show numerous neurological defects.

Identification
External Crossreferences and Linkouts ( 57 )
Sequence Crossreferences
NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
Other crossreferences
Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
KEGG Genes - Molecular building blocks of life in the genomic space.
modMine - A data warehouse for the modENCODE project
Linkouts
BioGRID - A database of protein and genetic interactions.
DroID - A comprehensive database of gene and protein interactions.
DRSC - Results frm RNAi screens
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
FlyMine - An integrated database for Drosophila genomics
Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
Synonyms and Secondary IDs (30)
Reported As
Symbol Synonym
Drp1
(Aparicio et al., 2019, Bouska et al., 2019, Gilmore-Hall et al., 2019, Gumeni et al., 2019, Lieber et al., 2019, Meltzer et al., 2019, Sênos Demarco and Jones, 2019, Sênos Demarco et al., 2019, Smith et al., 2019, Tsakiri et al., 2019, Xu et al., 2019, Yadav and Srikrishna, 2019, Zhou et al., 2019, Anding et al., 2018, Bardai et al., 2018, Bertolin et al., 2018, Gene Disruption Project members, 2018-, Lee et al., 2018, Lee et al., 2018, Ordonez et al., 2018, Cao et al., 2017, Lv et al., 2017, Rana et al., 2017, Transgenic RNAi Project members, 2017-, Altanbyek et al., 2016, Chao et al., 2016, Chen et al., 2016, Ding et al., 2016, Fowler and O'Sullivan, 2016, Wang et al., 2016, Wang et al., 2016, Zhang et al., 2016, Bhandari et al., 2015, Deng et al., 2015, Foriel et al., 2015, Gupte, 2015, Liu and Secombe, 2015, Liu et al., 2015, Parker et al., 2015, Zhu et al., 2015, Hwang et al., 2014, Merlo et al., 2014, Mulakkal et al., 2014, Muliyil and Narasimha, 2014, Sandoval et al., 2014, Shiba-Fukushima et al., 2014, Yun et al., 2014, Debattisti and Scorrano, 2013, Lee et al., 2013, Azad et al., 2012, Fabian and Brill, 2012, Humphrey et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Liu et al., 2011, Martinou and Youle, 2011, Rival et al., 2011, Vrailas-Mortimer et al., 2011, Imai et al., 2010, Liu and Lu, 2010, Poole et al., 2010, Vidal et al., 2010, Ziviani et al., 2010, Arsham and Neufeld, 2009, Venken et al., 2009, Venken et al., 2009, Yang et al., 2008, Yang et al., 2008, Aldridge et al., 2007, Engström et al., 2007)
l(2)22Fd
Name Synonyms
Dynamin Related Protein 1
Dynamin related protein 1
dynamin related protein-1
dynamin-related protein
dynamin-related protein 1
dynaminrelated protein 1
lethal(2)22Fc
lethal(2)22Fd
near dpp complementation group 2
near dpp complementation group 3
Secondary FlyBase IDs
  • FBgn0005566
  • FBgn0005579
  • FBgn0031438
  • FBgn0042649
Datasets (0)
Study focus (0)
Experimental Role
Project
Project Type
Title
References (173)