FB2025_02 , released April 17, 2025
Gene: Dmel\SPARC
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General Information
Symbol
Dmel\SPARC
Species
D. melanogaster
Name
Secreted protein, acidic, cysteine-rich
Annotation Symbol
CG6378
Feature Type
protein_coding_gene
FlyBase ID
FBgn0026562
Gene Model Status
Current
Stock Availability
14 publicly available
Gene Summary
Secreted protein, acidic, cysteine-rich (SPARC) encodes a small calcium and growth factor-binding secreted glycoprotein that is enriched in basement membranes. During cell competition, it is expressed in "loser" cells so they can avoid apoptosis mediated by the products of fwe and azot. [Date last reviewed: 2018-09-27] (FlyBase Gene Snapshot)
All Summaries
Also Known As

BM-40-SPARC, dsparc, BM-40/SPARC, BM40, CT19876

Key Links
Genomic Location
Cytogenetic map
97D3-97D3
Sequence location
Recombination map
3-92
RefSeq locus
NT_033777 REGION:26869238..26871995
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (14 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables calcium ion binding
inferred from biological aspect of ancestor with PANTHER:PTN001015480
(GO Reference Genome Project, 2011-)
inferred from electronic annotation with InterPro:IPR019577
(InterPro Project Members, 2004-)
enables collagen binding
inferred from biological aspect of ancestor with PANTHER:PTN001015480
(GO Reference Genome Project, 2011-)
enables extracellular matrix binding
inferred from biological aspect of ancestor with PANTHER:PTN001015480
(GO Reference Genome Project, 2011-)
Biological Process (9 terms)
Terms Based on Experimental Evidence (8 terms)
CV Term
Evidence
References
involved_in anterior Malpighian tubule development
inferred from mutant phenotype
(Bunt et al., 2010)
involved_in basement membrane assembly
inferred from mutant phenotype
(Shahab et al., 2015)
involved_in extracellular matrix constituent secretion
inferred from mutant phenotype
(Martinek et al., 2008)
involved_in larval fat body development
inferred from mutant phenotype
(Shahab et al., 2015)
involved_in larval feeding behavior
inferred from mutant phenotype
(Shahab et al., 2015)
involved_in Malpighian tubule morphogenesis
inferred from mutant phenotype
(Bunt et al., 2010)
involved_in mesoderm development
inferred from expression pattern
(Furlong et al., 2001)
involved_in trachea development
inferred from mutant phenotype
(Martinek et al., 2008)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in cell adhesion
inferred from sequence or structural similarity
(Hynes and Zhao, 2000)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
located_in extracellular matrix
inferred from high throughput direct assay
(Sarov et al., 2016)
located_in extracellular space
inferred from direct assay
(Portela et al., 2010)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
located_in extracellular matrix
inferred from sequence or structural similarity
(Hynes and Zhao, 2000)
is_active_in extracellular space
inferred from biological aspect of ancestor with PANTHER:PTN001015480
(GO Reference Genome Project, 2011-)
located_in extracellular space
inferred from electronic annotation with InterPro:IPR001999
(InterPro Project Members, 2004-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Secreted protein, acidic, cysteine-rich (SPARC) encodes a small calcium and growth factor-binding secreted glycoprotein that is enriched in basement membranes. During cell competition, it is expressed in "loser" cells so they can avoid apoptosis mediated by the products of fwe and azot. [Date last reviewed: 2018-09-27]
Summary (Interactive Fly)

basement membrane component required for basal lamina maturation and condensation of the ventral nerve cord

Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\SPARC for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry O97365)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.47

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
SPARC-RA
FBtr0085094
NM_143252
1143
304
SPARC-RB
FBtr0334309
NM_001276069
1131
304
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
SPARC-PA
FBpp0084464
35.2
304
4.26
O97365
NP_651509
AAF56632
SPARC-PB
FBpp0306424
35.2
304
4.26
O97365
NP_001262998
AGB96378
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

304 aa isoforms: SPARC-PA, SPARC-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\SPARC using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.92

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 6 -- 8
endoderm
(Martinek et al., 2008)
embryonic stage 6 -- 10
mesoderm
(Martinek et al., 2008)
embryonic stage 11 -- 12
plasmatocyte primordium

Comment: reported as plasmatocytes anlage

(Fisher et al., 2012)
anterior midgut primordium
(Martinek et al., 2008)
posterior midgut primordium
(Martinek et al., 2008)
embryonic stage 12 -- 13
fused midgut primordium
(Martinek et al., 2008)
embryonic stage 12 -- 17
embryonic/larval hemocyte
(Martinek et al., 2008)
embryonic stage 13 -- 16
embryonic/larval fat body
(Fisher et al., 2012)
embryonic/larval plasmatocyte
(Fisher et al., 2012)
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 4 -- 5
organism
(Martinek et al., 2008)
Additional Descriptive Data

SPARC transcript is first detected in cellularizing embryos. SPARC transcript is expressed at the onset of gastrulation, becoming enriched in invaginating mesoderm. As gastrulation progresses, SPARC transcript expression is restricted to mesoderm and invaginating endoderm. SPARC transcript is expressed in the anterior and posterior midgut primordia at embryonic stage 11. Expression in the developing midgut continues through germ band retraction; expression is also observed in hemocytes at this stage.

(Martinek et al., 2008)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 7 -- 8
mesoderm
(Martinek et al., 2008)
anterior midgut primordium
(Martinek et al., 2008)
posterior midgut primordium
(Martinek et al., 2008)
embryonic stage 12 -- 17
embryonic/larval hemocyte
(Martinek et al., 2008)
embryonic stage 14 -- 17
larval ventral nerve cord
(Martinek et al., 2008)
larval brain
(Martinek et al., 2008)
embryonic/larval epidermis
(Martinek et al., 2008)
embryonic stage 16
embryonic/larval hemocyte
(Wolfstetter and Holz, 2012)
larval visceral muscle cell
(Wolfstetter and Holz, 2012)
embryonic stage 16 -- 17
embryonic/larval fat body
(Martinek et al., 2008)
larval channel glial cell
(Martinek et al., 2008)
Additional Descriptive Data

SPARC protein is expressed in mesoderm and in the anterior and posterior midgut primordia in gastrulating embryos. SPARC protein is expressed in hemocytes at from embryonic stage 12, and is secreted from hemocytes into the basal lamina surrounding the brain, ventral nerve cord, VNC channels, channel glia, and epidermis. SPARC protein is also detected in the fat bodies of late stage embryos.

(Martinek et al., 2008)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in extracellular matrix
inferred from high throughput direct assay
(Sarov et al., 2016)
located_in extracellular space
inferred from direct assay
(Portela et al., 2010)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\SPARC in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 8 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 14 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of SPARC
Transgenic constructs containing regulatory region of SPARC
Aberrations (Deficiencies and Duplications) ( 4 )
Inferred from experimentation ( 4 )
Gene partially disrupted in
Df(3R)nm136
(Martinek et al., 2008)
Gene disrupted in
Df(3R)nm136
(Shahab et al., 2015)
Gene duplicated in
Dp(3;2)CH322-97107
(Shahab et al., 2015)
Gene not disrupted in
Df(3R)SPARC1510B
(Duncan et al., 2020)
Df(3R)SPARC1510D
(Duncan et al., 2020)
Inferred from location ( 6 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal | recessive
lethal - all die during larval stage
lethal - all die during larval stage, with Scer\GAL4da.G32
lethal - all die during larval stage, with Scer\GAL4Mef2.PR
lethal - all die during larval stage, with Scer\GAL4SPARC-MI00329-GAL4
lethal - all die during larval stage (with Df(3R)BSC524)
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
abnormal developmental rate, with Scer\GAL4Cg.PA
abnormal developmental rate (with Df(3R)BSC524)
abnormal feeding behavior | larval stage
abnormal feeding behavior | larval stage, with Scer\GAL4Cg.PA
abnormal feeding behavior | larval stage (with Df(3R)BSC524)
decreased body size | larval stage (with Df(3R)BSC524)
decreased cell death | pupal stage, with Scer\GAL4elav.PU
decreased cell death | pupal stage, with Scer\GAL4GMR.PF
majority die during first instar larval stage
majority die during second instar larval stage
majority die during second instar larval stage, with Scer\GAL4da.G32
majority die during second instar larval stage, with Scer\GAL4SPARC-MI00329-GAL4
majority die during second instar larval stage (with Df(3R)BSC524)
some die during second instar larval stage
Phenotype manifest in
Allele
adult heart | adult stage, with Scer\GAL4tin.CΔ4
basement membrane, with Scer\GAL4Cg.PA
embryonic/first instar larval cuticle
embryonic/larval fat body, with Scer\GAL4Cg.PA
embryonic/larval fat body (with Df(3R)BSC524)
embryonic/larval fat body (with SPARCMI00329)
embryonic/larval fat body (with SPARCnm136)
embryonic/larval proventriculus (with Df(3R)BSC524)
larval tracheal system
photoreceptor neuron | pupal stage, with Scer\GAL4elav.PU
photoreceptor neuron | pupal stage, with Scer\GAL4GMR.PF
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (12)
Hsap\SPARC
13 of 14
Yes
Yes
1  
Hsap\SPARCL1
11 of 14
No
Yes
Hsap\AGRN
1 of 14
No
No
Hsap\FST
1 of 14
No
No
3  
Hsap\FSTL1
1 of 14
No
Yes
Hsap\FSTL4
1 of 14
No
Yes
Hsap\FSTL5
1 of 14
No
Yes
Hsap\SMOC1
1 of 14
No
No
1  
Hsap\SPOCK1
1 of 14
No
No
Hsap\SPOCK2
1 of 14
No
No
1  
Hsap\SPOCK3
1 of 14
No
No
1  
Hsap\TG
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (11)
Rnor\Sparc
13 of 14
Yes
Yes
Rnor\Sparcl1
11 of 14
No
Yes
Rnor\Agrn
1 of 14
No
No
Rnor\Fstl1
1 of 14
No
Yes
Rnor\Fstl4
1 of 14
No
Yes
Rnor\Fstl5
1 of 14
No
Yes
Rnor\Fst
1 of 14
No
No
Rnor\Smoc1
1 of 14
No
No
Rnor\Spock1
1 of 14
No
No
Rnor\Spock2
1 of 14
No
No
Rnor\Spock3
1 of 14
No
No
Mus musculus (laboratory mouse) (11)
Mmus\Sparc
13 of 14
Yes
Yes
Mmus\Sparcl1
10 of 14
No
Yes
Mmus\Fstl1
1 of 14
No
Yes
Mmus\Fstl4
1 of 14
No
Yes
Mmus\Fstl5
1 of 14
No
Yes
Mmus\Fst
1 of 14
No
No
Mmus\Smoc1
1 of 14
No
No
Mmus\Spock1
1 of 14
No
No
Mmus\Spock2
1 of 14
No
No
Mmus\Spock3
1 of 14
No
No
Mmus\Tmeff1
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (4)
Xtro\sparc
10 of 13
Yes
Yes
Xtro\agrn
1 of 13
No
No
Xtro\smoc1
1 of 13
No
No
Xtro\spock2
1 of 13
No
No
Danio rerio (Zebrafish) (14)
Drer\sparc
13 of 14
Yes
Yes
Drer\sparcl1
10 of 14
No
Yes
Drer\sparcl2
6 of 14
No
Yes
Drer\agrn
1 of 14
No
No
Drer\fstb
1 of 14
No
No
Drer\fstl1a
1 of 14
No
Yes
Drer\fstl1b
1 of 14
No
Yes
Drer\fstl3
1 of 14
No
No
Drer\fstl4
1 of 14
No
Yes
Drer\fstl5
1 of 14
No
Yes
Drer\smoc1
1 of 14
No
No
Drer\spock1
1 of 14
No
No
Drer\spock2
1 of 14
No
No
Drer\spock3
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (5)
Cele\ost-1
13 of 14
Yes
Yes
Cele\agr-1
1 of 14
No
No
Cele\C08G9.2
1 of 14
No
No
Cele\smoc-1
1 of 14
No
No
Cele\test-1
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (3)
Agam\AgaP_AGAP000305
11 of 12
Yes
Yes
Agam\AgaP_AGAP003400
1 of 12
No
No
Agam\AgaP_AGAP007489
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:SPARC. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (3)
Cow
1 of 13
Fs
1 of 13
magu
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Allele
Disease
Evidence
References
SPARCUAS.cMa
model of  cardiomyopathy
CEA
(Vaughan et al., 2018)
Potential Models Based on Orthology ( 1 )
Modifiers Based on Experimental Evidence ( 3 )
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
SPARC; secreted protein acidic and cysteine rich
13 of 14
182120
 
SPARCL1; SPARC like 1
11 of 14
606041
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Interactions
      Summary of Physical Interactions
      Summary of Genetic Interactions
      Interaction Browsers
      View in FlyBase Interactions Browser   View in MIST tool (external link)
      Please look at the allele data for full details of the genetic interactions
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      Klf15
      suppressible
      SPARC
      (Hartley et al., 2016)
      Myc
      suppressible
      SPARC
      (Portela et al., 2010)
      Myc
      enhanceable
      SPARC
      (Portela et al., 2010)
      Ras85D|scrib
      suppressible
      SPARC
      (Bakopoulos et al., 2023)
      Ras85D|scrib
      enhanceable
      SPARC
      (Bakopoulos et al., 2023)
      wupA
      suppressible
      SPARC
      (Casas-Tintó et al., 2016)
      External Data
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      MIST (genetic) - An integrated Molecular Interaction Database
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Pathways
      Signaling Pathways (FlyBase)
      Metabolic Pathways
      FlyBase
      External Links
      External Data
      Class of Gene
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      3R
      Recombination map
      3-92
      Cytogenetic map
      97D3-97D3
      Sequence location
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      97D3-97D3
      Limits computationally determined from genome sequence between P{lacW}His2AvL1602 and P{PZ}sda03884
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      97D1-97D4
      (determined by in situ hybridisation)
      (Martinek et al., 2000)
      Experimentally Determined Recombination Data
      Location

      3-92

      (FlyBase, 2016)

      3-88.9

      (Comeron et al., 2012)
      Left of (cM)
      Right of (cM)
      Notes
      Stocks and Reagents
      Stocks (14)
      Genomic Clones (13)
       

      Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

      cDNA Clones (238)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequenced
      BDGP DGC clones
      Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      Antibody Information
      Laboratory Generated Antibodies
       

      polyclonal

      (Khalili et al., 2021)

      monoclonal

      (Portela et al., 2010)
      Commercially Available Antibodies
       
      Cell Line Information
      Publicly Available Cell Lines
       
        Other Stable Cell Lines
         
          Other Comments
          Relationship to Other Genes
          Source for database merge of

          Source for merge of: BM-40/SPARC anon- EST:Posey291

          (Bayraktaroglu, 2000.11.2)
          Additional comments
          Nomenclature History
          Source for database identify of

          Source for identity of: SPARC BM-40-SPARC

          (FlyBase, 2009-)
          Nomenclature comments

          Renamed from 'BM-40-SPARC' to 'SPARC' to reflect usage in the literature, provide a briefer symbol, and to be consistent with the symbol of the mammalian ortholog.

          (FlyBase, 2009-)
          Etymology
          Synonyms and Secondary IDs (16)
          Reported As
          Symbol Synonym
          BM-40 Sparc
          (Rehwinkel et al., 2004)
          BM-40-SPARC
          (Ugrankar et al., 2018, Ríos-Barrera et al., 2017, Sarov et al., 2016, Dequéant et al., 2015, Van Bortle et al., 2015, Zang et al., 2015, Ibrahim et al., 2013, Kwon et al., 2013, Kwon et al., 2013, Butchar et al., 2012, Fu and Whitfield, 2012, Japanese National Institute of Genetics, 2012.5.21, Cherbas et al., 2011, Friedman et al., 2011, Venken et al., 2011, Venken et al., 2011, Hollien and Weissman, 2006)
          BM-40/SPARC
          (Loop et al., 2004, Butler et al., 2003, Egger et al., 2002)
          BM40
          (Olivares et al., 2023, Eble et al., 2001)
          CG6378
          (Ibrahim et al., 2013, Mosallanejad et al., 2010, Ni et al., 2010.12.1, Portela et al., 2010, Keleman et al., 2009.8.5, Hollien and Weissman, 2006, Roos et al., 2005, Furlong et al., 2001)
          CT19876
          (Hynes and Zhao, 2000, Hynes and Zhao, 2000)
          SPARC
          (Pignataro et al., 2024, Qu et al., 2024, Khalili et al., 2023, Corrales et al., 2022, Hultmark and Andó, 2022, Baker et al., 2021, Costa-Rodrigues et al., 2021, Khalili et al., 2021, Michki et al., 2021, Csordás et al., 2020, Duncan et al., 2020, Gutiérrez-Martínez et al., 2020, Parra and Johnston, 2020, Pastor-Pareja, 2020, Rust et al., 2020, Töpfer and Holz, 2020, Blice-Baum et al., 2019, Ramos-Lewis and Page-McCaw, 2019, Ray et al., 2019, Wittes and Schüpbach, 2019, Croset et al., 2018, Chen et al., 2017, Crest et al., 2017, Di Giacomo et al., 2017, Hughes and Jacobs, 2017, Ríos-Barrera et al., 2017, Yadav et al., 2017, Di Gregorio et al., 2016, Dequéant et al., 2015, Gogna et al., 2015, Shahab et al., 2015, Tiwari et al., 2015, Arefin et al., 2014, Merino et al., 2013, Wolfstetter and Holz, 2012, Pastor-Pareja and Xu, 2011, Martinek et al., 2008, Junion et al., 2007, Hollien and Weissman, 2006, Martinek et al., 2002, Martinek et al., 2001, Martinek et al., 2000)
          Sparc
          (Walther et al., 2024, Paraskevopoulos and McGuigan, 2021, Casas-Tintó et al., 2016, Merino et al., 2016, Casas-Tintó et al., 2015, Merino et al., 2015, Coelho et al., 2013, Levayer and Moreno, 2013, Baker, 2011)
          anon-EST:Posey291
          dSPARC
          (Portela et al., 2010, Martinek et al., 2002)
          dSparc
          (Hartley et al., 2016)
          dsparc
          (Weavers and Skaer, 2013, Bunt et al., 2010, Portela et al., 2010, Martinek et al., 2008, Martinek and Ringuette, 2004)
          sparc
          (Bakopoulos et al., 2023, Coelho et al., 2013, Moore et al., 2013)
          Name Synonyms
          BM-40-SPARC
          BM-40-secreted protein acidic and rich in cysteine
          (Dequéant et al., 2015)
          Osteonectin
          (Banyai and Patthy, 2004)
          SPARC
          (Amoyel and Bach, 2014)
          Secreted protein, acidic, cysteine-rich
          Secondary FlyBase IDs
          • FBgn0027691
          Datasets (0)
          Study focus (0)
          Experimental Role
          Project
          Project Type
          Title
          Study result (0)
          Result
          Result Type
          Title
          External Crossreferences and Linkouts ( 47 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
          Other crossreferences
          AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
          DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
          EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
          FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
          FlyMine - An integrated database for Drosophila genomics
          InterPro - A database of protein families, domains and functional sites
          KEGG Genes - Molecular building blocks of life in the genomic space.
          MARRVEL_MODEL - MARRVEL (model organism gene)
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
          DroID - A comprehensive database of gene and protein interactions.
          DRSC - Results frm RNAi screens
          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          Flygut - An atlas of the Drosophila adult midgut
          FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
          Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
          MIST (genetic) - An integrated Molecular Interaction Database
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          References (129)