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Gene Dmel\BM-40-SPARC

General Information
Symbol	Dmel\BM-40-SPARC	Species	D. melanogaster
Name	BM-40-SPARC	Annotation symbol	CG6378
Feature type	protein_coding_gene	FlyBase ID	FBgn0026562
Gene Model Status	Current	Stock availability	5 publicly available
Also Known As	SPARC, dsparc, BM-40/SPARC, CT19876
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	97D3-97D3	Sequence location	3R:22,694,960..22,697,717 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene BM-40-SPARC is referred to in FlyBase by the symbol Dmel\BM-40-SPARC (CG6378, FBgn0026562). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: calcium ion binding. There is experimental evidence that it is involved in the biological process: trachea development; anterior Malpighian tubule development; Malpighian tubule morphogenesis; extracellular matrix constituent secretion; mesoderm development; ventral cord development. 25 alleles are reported. The phenotypes of these alleles are annotated with: embryonic/first instar larval cuticle; presumptive embryonic/larval tracheal system. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: EF-Hand 1, calcium-binding site; EF-hand-like domain; Follistatin-like, N-terminal; Osteonectin-like, conserved site; SPARC/Testican, calcium-binding domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression. Peak expression observed within 12-24 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, larval hindgut, adult heart, larval/adult fat body, adult spermathecae, adult male accessory gland, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult midgut, adult hindgut, larval salivary gland, larval trachea, adult testis. Comments on Affy2 ProbeSet: ProbeSet 1625825_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of BM-40-SPARC. Gene sequence location is 3R:22694960..22697717.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 97D3-97D3   Limits computationally determined from genome sequence between P{lacW}His2AvL1602 and P{PZ}sda03884
Experimentally Determined Cytological Location
Cytogenetic map Notes References 97D1-97D4   (determined by in situ hybridisation)   (Martinek et al., 2000)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\BM-40-SPARC for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Low-frequency RNA-Seq exon junction(s) not annotated. Gene model reviewed during 5.47
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) BM-40-SPARC-RA FBtr0085094  NM_143252   1143   304 BM-40-SPARC-RB FBtr0334309  NM_001276069   1131   304
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein BM-40-SPARC-PA   FBpp0084464   35.2   304   4.26     NP_651509   AAF56632 BM-40-SPARC-PB   FBpp0306424   35.2   304   4.26     NP_001262998   AGB96378
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Osteonectin-like, conserved site (IPR001999) EF-hand-like domain (IPR011992) EF-Hand 1, calcium-binding site (IPR018247) Follistatin-like, N-terminal (IPR003645) SPARC/Testican, calcium-binding domain (IPR019577)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA695181   AA803441   AE014297 AAF56632   AF171872   AE014297 AGB96378   AI062733   AI062802   AI062889   AI063761   AI108633   AI108963   AI114297   AI133848   AI134848   AI134920   AI238421   AI238894   AI238939   AI239090   AI259625   AI259921   AI297685   AI387059   AI389590   AI389823   AI402466   AI403759   AI404017   AI404805   AI404837   AI406189   AI513956   AI518650   AI532870   AI533180   AI534476   AI541976   AI543689   AI546709   AJ133736 CAB39319   AY071738 AAL49360   AY232231   BG632694   BG635562   BG635625   BG635853   BG636910   BG637034   BG637057   BG637074   BG637079   BG637182   BG637277   BG637496   BG640231   BG640703   BG640815   BG641018   BG641287   BI141852   BI162304   BI228460   BI228774   BI234216   BI243074   BI352543   BI352759   BI353081   BI353358   BI353638   BI355407   BI364987   BI366573   BI369823   BI371369   BI371701   BI373804   BI563410   BI565778   BI566007   BI574314   BI582189   BI583731   BI584330   BI590188   BI604612   BI605881   BI609520   BI615918   BI619329   BI620554   BI623116   BI623198   BI626310   BI628713   BI632273   BI632377   BI633670   BI633736   BI633737   BI635033   BI635056   BI635448   BI635539   BI635665   BI635671   BI635936   BI636395   BI636729   BI637389   BI637514   BI638613   BI640894   BI641705   BP547277   BP550084   BP550085   BT128781   CK132224   CK604323   CK604324   CK604533   CK604534   CK658405   CK658517   CK659187   CO152853   CO153237   CO153242   CO153591   CO153784   CO154560   CO155528   CO156000   CO156105   CO156441   CO157011   CO179386   CO185721   CO193171   CO287614   CO292746   CO307345   CO314130   CO317044   CO322293   CO324881   CO335425   CO335704   CO336050   CO336083   CO336150   CO336661   CO337326   CO337347   CO337665   CO337771   CO337902   CO337982   CO338222   CO338281   CO338678   CO338712   CO338849   CO339993   EC068450   EC068451   EC081458   EC086608   EC089482   EC207323   EC214144   EC223828   EC226469   EC246468   EC255784   EC260839   EC260881   EC261278   EC261295   EC262987   EC263227   EC263406   EC263538   EC263999   EC264285   EC264287   EC264329   EC264523   EC265038   EC265508   EC265590   EC265740   EC265751   EC266168   EC266176   EC266577   EC266791   EC267106   EC267185   EC267578   EC267760   EL873372   EL880756   EL880868   EL880869   EL881894   EL882748   EL882749   EL882855   EL882856   EL882951   EL885780   EL885781   GH751290   GH753701   GH758725   GH771789   GH773772   GH773810   GH780815   GH789096   GH790075   GH798657   GH802043   GH803057   GH809184   GH811136   GH816083   GH816111   GH829049   GH839049   GH841231   GH841868   GH850851   GH853339   GH854700   GH862246   GH866369   GH867783   GH874797   GH876194   GH876850   GH877918   GH884489   GH894974   GH906452   GH908783   GH909693   GH910310   GH910450   GH915982   GH918640   GH919306   GH921918   GH923947   GH934892   GH936582   GH941024
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	O97365 Q8SY75
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 11 -- 12   plasmatocyte primordium   (Fisher et al., 2012) Comment:reported as plasmatocytes anlage embryonic stage 13 -- 16   embryonic/larval fat body   (Fisher et al., 2012) plasmatocyte   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, larval hindgut, adult heart, larval/adult fat body, adult spermathecae, adult male accessory gland, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult midgut, adult hindgut, larval salivary gland, larval trachea, adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    209.1 Larval Midgut    42.5 Larval Hindgut    515.7 Larval Malpighian Tubules    65 Larval Fat Body    4102.1 Larval Salivary Gland    127.2 Larval Trachea    284.325 Larval Carcass    552.55 Adult Head    2146.9 Adult Eye    1472.95 Adult Brain    1475.7 Adult Thoracic-Abdominal Ganglion    2285.3 Adult Crop    1089.2 Adult Midgut    129.3 Adult Hindgut    404.1 Adult Malpighian Tubules    52.1 Adult Fat Body    3933.7 Adult Salivary Gland    51.8 Adult Heart    3974.1 Adult VirginFemale Spermatheca    3016.8 Adult InseminatedFemale Spermatheca    3406.4 Adult Ovary    95.1 Adult Testis    122.9 Adult Male Accessory Gland    727.7 Adult Carcass    2958 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    209.1 Larval Midgut    42.5 Larval Hindgut  515.7 Larval Malpighian Tubules    65 Larval Fat Body  (4102.1) Larval Salivary Gland    127.2 Larval Trachea    284.325 Larval Carcass  (552.55) Adult Head  (2146.9) Adult Eye  (1472.95) Adult Brain  (1475.7) Adult Thoracic-Abdominal Ganglion  (2285.3) Adult Crop  (1089.2) Adult Midgut    129.3 Adult Hindgut    404.1 Adult Malpighian Tubules    52.1 Adult Fat Body  (3933.7) Adult Salivary Gland    51.8 Adult Heart  (3974.1) Adult VirginFemale Spermatheca  (3016.8) Adult InseminatedFemale Spermatheca  (3406.4) Adult Ovary    95.1 Adult Testis    122.9 Adult Male Accessory Gland  (727.7) Adult Carcass  (2958) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    209.1 Larval Midgut    42.5 Larval Hindgut    515.7 Larval Malpighian Tubules    65 Larval Fat Body  (4102.1) Larval Salivary Gland    127.2 Larval Trachea    284.325 Larval Carcass    552.55 Adult Head  (2146.9) Adult Eye  (1472.95) Adult Brain  (1475.7) Adult Thoracic-Abdominal Ganglion  (2285.3) Adult Crop  (1089.2) Adult Midgut    129.3 Adult Hindgut    404.1 Adult Malpighian Tubules    52.1 Adult Fat Body  (3933.7) Adult Salivary Gland    51.8 Adult Heart  (3974.1) Adult VirginFemale Spermatheca  (3016.8) Adult InseminatedFemale Spermatheca  (3406.4) Adult Ovary    95.1 Adult Testis    122.9 Adult Male Accessory Gland    727.7 Adult Carcass  (2958) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    209.1 Larval Midgut    42.5 Larval Hindgut    515.7 Larval Malpighian Tubules    65 Larval Fat Body    4102.1 Larval Salivary Gland    127.2 Larval Trachea    284.325 Larval Carcass    552.55 Adult Head    2146.9 Adult Eye    1472.95 Adult Brain    1475.7 Adult Thoracic-Abdominal Ganglion    2285.3 Adult Crop    1089.2 Adult Midgut    129.3 Adult Hindgut    404.1 Adult Malpighian Tubules    52.1 Adult Fat Body    3933.7 Adult Salivary Gland    51.8 Adult Heart    3974.1 Adult VirginFemale Spermatheca    3016.8 Adult InseminatedFemale Spermatheca    3406.4 Adult Ovary    95.1 Adult Testis    122.9 Adult Male Accessory Gland    727.7 Adult Carcass    2958 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    209.1 Larval Midgut    42.5 Larval Hindgut    515.7 Larval Malpighian Tubules    65 Larval Fat Body    4102.1 Larval Salivary Gland    127.2 Larval Trachea    284.325 Larval Carcass    552.55 Adult Head    2146.9 Adult Eye    1472.95 Adult Brain    1475.7 Adult Thoracic-Abdominal Ganglion    2285.3 Adult Crop    1089.2 Adult Midgut    129.3 Adult Hindgut    404.1 Adult Malpighian Tubules    52.1 Adult Fat Body    3933.7 Adult Salivary Gland    51.8 Adult Heart    3974.1 Adult VirginFemale Spermatheca    3016.8 Adult InseminatedFemale Spermatheca    3406.4 Adult Ovary    95.1 Adult Testis    122.9 Adult Male Accessory Gland    727.7 Adult Carcass    2958 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    209.1 Larval Midgut    42.5 Larval Hindgut  515.7 Larval Malpighian Tubules    65 Larval Fat Body  (4102.1) Larval Salivary Gland    127.2 Larval Trachea    284.325 Larval Carcass  552.55 Adult Head  (2146.9) Adult Eye  (1472.95) Adult Brain  (1475.7) Adult Thoracic-Abdominal Ganglion  (2285.3) Adult Crop  (1089.2) Adult Midgut    129.3 Adult Hindgut    404.1 Adult Malpighian Tubules    52.1 Adult Fat Body  (3933.7) Adult Salivary Gland    51.8 Adult Heart  (3974.1) Adult VirginFemale Spermatheca  (3016.8) Adult InseminatedFemale Spermatheca  (3406.4) Adult Ovary    95.1 Adult Testis    122.9 Adult Male Accessory Gland  727.7 Adult Carcass  (2958) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    209.1 Larval Midgut    42.5 Larval Hindgut    515.7 Larval Malpighian Tubules    65 Larval Fat Body  (4102.1) Larval Salivary Gland    127.2 Larval Trachea    284.325 Larval Carcass    552.55 Adult Head  (2146.9) Adult Eye  1472.95 Adult Brain  1475.7 Adult Thoracic-Abdominal Ganglion  (2285.3) Adult Crop  1089.2 Adult Midgut    129.3 Adult Hindgut    404.1 Adult Malpighian Tubules    52.1 Adult Fat Body  (3933.7) Adult Salivary Gland    51.8 Adult Heart  (3974.1) Adult VirginFemale Spermatheca  (3016.8) Adult InseminatedFemale Spermatheca  (3406.4) Adult Ovary    95.1 Adult Testis    122.9 Adult Male Accessory Gland    727.7 Adult Carcass  (2958) Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    209.1 Larval Midgut    42.5 Larval Hindgut    515.7 Larval Malpighian Tubules    65 Larval Fat Body    4102.1 Larval Salivary Gland    127.2 Larval Trachea    284.325 Larval Carcass    552.55 Adult Head    2146.9 Adult Eye    1472.95 Adult Brain    1475.7 Adult Thoracic-Abdominal Ganglion    2285.3 Adult Crop    1089.2 Adult Midgut    129.3 Adult Hindgut    404.1 Adult Malpighian Tubules    52.1 Adult Fat Body    3933.7 Adult Salivary Gland    51.8 Adult Heart    3974.1 Adult VirginFemale Spermatheca    3016.8 Adult InseminatedFemale Spermatheca    3406.4 Adult Ovary    95.1 Adult Testis    122.9 Adult Male Accessory Gland    727.7 Adult Carcass    2958 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    2146.9   NA  Eye    1472.95   NA  Brain    1475.7   209.1  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    2285.3   NA  Crop    1089.2   42.5  Midgut    129.3   515.7  Hindgut    404.1   65  Malpighian Tubules    52.1   4102.1  Fat Body    3933.7   127.2  Salivary Gland    no informative data   NA  Heart    3974.1   284.325  Trachea    NA   NA  VirginFemale Spermatheca    3016.8   NA  InseminatedFemale Spermatheca    3406.4   NA  Ovary    95.1   NA  Testis    122.9   NA  Male Accessory Gland    727.7   552.55  Carcass    2958 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    41 central nervous system, larvae L3    49 central nervous system, pupae P8    65 head, virgin 1-day female    357 head, virgin 4-day female    276 head, virgin 20-day female    398 head, mated 1-day female    292 head, mated 4-day female    373 head, mated 20-day female    316 head, mated 1-day male    338 head, mated 4-day male    273 head, mated 20-day male    379 salivary gland, larvae L3 wandering    18 salivary gland, white prepupae    44 digestive system, larvae L3 wandering    23 digestive system, 1-day adult    70 digestive system, 4-day adult    33 digestive system, 20-day adult    25 fat body, larvae L3 wandering    524 fat body, white prepupae    313 fat body, pupae P8    530 carcass, larvae L3 wandering    63 carcass, 1-day adult    302 carcass, 4-day adult    230 carcass, 20-day adult    208 ovary, virgin 4-day female    13 ovary, mated 4-day female    11 testis, mated 4-day male    36 accessory gland, mated 4-day male    55 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (41) central nervous system, larvae L3  (49) central nervous system, pupae P8  (65) head, virgin 1-day female  (357) head, virgin 4-day female  (276) head, virgin 20-day female  (398) head, mated 1-day female  (292) head, mated 4-day female  (373) head, mated 20-day female  (316) head, mated 1-day male  (338) head, mated 4-day male  (273) head, mated 20-day male  (379) salivary gland, larvae L3 wandering    18 salivary gland, white prepupae  (44) digestive system, larvae L3 wandering    23 digestive system, 1-day adult  (70) digestive system, 4-day adult  (33) digestive system, 20-day adult    25 fat body, larvae L3 wandering  (524) fat body, white prepupae  (313) fat body, pupae P8  (530) carcass, larvae L3 wandering  (63) carcass, 1-day adult  (302) carcass, 4-day adult  (230) carcass, 20-day adult  (208) ovary, virgin 4-day female    13 ovary, mated 4-day female    11 testis, mated 4-day male  (36) accessory gland, mated 4-day male  (55) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    41 central nervous system, larvae L3    49 central nervous system, pupae P8    65 head, virgin 1-day female  (357) head, virgin 4-day female  (276) head, virgin 20-day female  (398) head, mated 1-day female  (292) head, mated 4-day female  (373) head, mated 20-day female  (316) head, mated 1-day male  (338) head, mated 4-day male  (273) head, mated 20-day male  (379) salivary gland, larvae L3 wandering    18 salivary gland, white prepupae    44 digestive system, larvae L3 wandering    23 digestive system, 1-day adult    70 digestive system, 4-day adult    33 digestive system, 20-day adult    25 fat body, larvae L3 wandering  (524) fat body, white prepupae  (313) fat body, pupae P8  (530) carcass, larvae L3 wandering    63 carcass, 1-day adult  (302) carcass, 4-day adult  (230) carcass, 20-day adult  (208) ovary, virgin 4-day female    13 ovary, mated 4-day female    11 testis, mated 4-day male    36 accessory gland, mated 4-day male    55 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    41 central nervous system, larvae L3    49 central nervous system, pupae P8    65 head, virgin 1-day female    357 head, virgin 4-day female    276 head, virgin 20-day female    398 head, mated 1-day female    292 head, mated 4-day female    373 head, mated 20-day female    316 head, mated 1-day male    338 head, mated 4-day male    273 head, mated 20-day male    379 salivary gland, larvae L3 wandering    18 salivary gland, white prepupae    44 digestive system, larvae L3 wandering    23 digestive system, 1-day adult    70 digestive system, 4-day adult    33 digestive system, 20-day adult    25 fat body, larvae L3 wandering    524 fat body, white prepupae    313 fat body, pupae P8    530 carcass, larvae L3 wandering    63 carcass, 1-day adult    302 carcass, 4-day adult    230 carcass, 20-day adult    208 ovary, virgin 4-day female    13 ovary, mated 4-day female    11 testis, mated 4-day male    36 accessory gland, mated 4-day male    55 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    41 central nervous system, larvae L3    49 central nervous system, pupae P8    65 head, virgin 1-day female    357 head, virgin 4-day female    276 head, virgin 20-day female    398 head, mated 1-day female    292 head, mated 4-day female    373 head, mated 20-day female    316 head, mated 1-day male    338 head, mated 4-day male    273 head, mated 20-day male    379 salivary gland, larvae L3 wandering    18 salivary gland, white prepupae    44 digestive system, larvae L3 wandering    23 digestive system, 1-day adult    70 digestive system, 4-day adult    33 digestive system, 20-day adult    25 fat body, larvae L3 wandering    524 fat body, white prepupae    313 fat body, pupae P8    530 carcass, larvae L3 wandering    63 carcass, 1-day adult    302 carcass, 4-day adult    230 carcass, 20-day adult    208 ovary, virgin 4-day female    13 ovary, mated 4-day female    11 testis, mated 4-day male    36 accessory gland, mated 4-day male    55 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (41) central nervous system, larvae L3  (49) central nervous system, pupae P8  (65) head, virgin 1-day female  (357) head, virgin 4-day female  (276) head, virgin 20-day female  (398) head, mated 1-day female  (292) head, mated 4-day female  (373) head, mated 20-day female  (316) head, mated 1-day male  (338) head, mated 4-day male  (273) head, mated 20-day male  (379) salivary gland, larvae L3 wandering    18 salivary gland, white prepupae  (44) digestive system, larvae L3 wandering    23 digestive system, 1-day adult  (70) digestive system, 4-day adult  (33) digestive system, 20-day adult    25 fat body, larvae L3 wandering  (524) fat body, white prepupae  (313) fat body, pupae P8  (530) carcass, larvae L3 wandering  (63) carcass, 1-day adult  (302) carcass, 4-day adult  (230) carcass, 20-day adult  (208) ovary, virgin 4-day female    13 ovary, mated 4-day female    11 testis, mated 4-day male  (36) accessory gland, mated 4-day male  (55) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    41 central nervous system, larvae L3    49 central nervous system, pupae P8    65 head, virgin 1-day female  (357) head, virgin 4-day female  (276) head, virgin 20-day female  (398) head, mated 1-day female  (292) head, mated 4-day female  (373) head, mated 20-day female  (316) head, mated 1-day male  (338) head, mated 4-day male  (273) head, mated 20-day male  (379) salivary gland, larvae L3 wandering    18 salivary gland, white prepupae    44 digestive system, larvae L3 wandering    23 digestive system, 1-day adult    70 digestive system, 4-day adult    33 digestive system, 20-day adult    25 fat body, larvae L3 wandering  (524) fat body, white prepupae  (313) fat body, pupae P8  (530) carcass, larvae L3 wandering    63 carcass, 1-day adult  (302) carcass, 4-day adult  (230) carcass, 20-day adult  (208) ovary, virgin 4-day female    13 ovary, mated 4-day female    11 testis, mated 4-day male    36 accessory gland, mated 4-day male    55 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    41 central nervous system, larvae L3    49 central nervous system, pupae P8    65 head, virgin 1-day female    357 head, virgin 4-day female    276 head, virgin 20-day female    398 head, mated 1-day female    292 head, mated 4-day female    373 head, mated 20-day female    316 head, mated 1-day male    338 head, mated 4-day male    273 head, mated 20-day male    379 salivary gland, larvae L3 wandering    18 salivary gland, white prepupae    44 digestive system, larvae L3 wandering    23 digestive system, 1-day adult    70 digestive system, 4-day adult    33 digestive system, 20-day adult    25 fat body, larvae L3 wandering    524 fat body, white prepupae    313 fat body, pupae P8    530 carcass, larvae L3 wandering    63 carcass, 1-day adult    302 carcass, 4-day adult    230 carcass, 20-day adult    208 ovary, virgin 4-day female    13 ovary, mated 4-day female    11 testis, mated 4-day male    36 accessory gland, mated 4-day male    55 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression. Peak expression observed within 12-24 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    4 embryo 04-06hr    6 embryo 06-08hr    21 embryo 08-10hr    33 embryo 10-12hr    96 embryo 12-14hr    106 embryo 14-16hr    414 embryo 16-18hr    613 embryo 18-20hr    994 embryo 20-22hr    650 embryo 22-24hr    492 larva L1    477 larva L2    492 larva L3 12hr old    701 larva L3 puffstage 1-2    204 larva L3 puffstage 3-6    141 larva L3 puffstage 7-9    86 white prepupae new    93 white prepupae 12hr    218 white prepupae 24hr    179 pupae 2d postWPP    170 pupae 3d postWPP    314 pupae 4d postWPP    245 adult male 01day    282 adult male 05day    211 adult male 30day    152 adult female 01day    245 adult female 05day    102 adult female 30day    114 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    4 embryo 04-06hr    6 embryo 06-08hr    21 embryo 08-10hr  (33) embryo 10-12hr  (96) embryo 12-14hr  (106) embryo 14-16hr  (414) embryo 16-18hr  (613) embryo 18-20hr  (994) embryo 20-22hr  (650) embryo 22-24hr  (492) larva L1  (477) larva L2  (492) larva L3 12hr old  (701) larva L3 puffstage 1-2  (204) larva L3 puffstage 3-6  (141) larva L3 puffstage 7-9  (86) white prepupae new  (93) white prepupae 12hr  (218) white prepupae 24hr  (179) pupae 2d postWPP  (170) pupae 3d postWPP  (314) pupae 4d postWPP  (245) adult male 01day  (282) adult male 05day  (211) adult male 30day  (152) adult female 01day  (245) adult female 05day  (102) adult female 30day  (114) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    4 embryo 04-06hr    6 embryo 06-08hr    21 embryo 08-10hr    33 embryo 10-12hr    96 embryo 12-14hr  106 embryo 14-16hr  (414) embryo 16-18hr  (613) embryo 18-20hr  (994) embryo 20-22hr  (650) embryo 22-24hr  (492) larva L1  (477) larva L2  (492) larva L3 12hr old  (701) larva L3 puffstage 1-2  (204) larva L3 puffstage 3-6  (141) larva L3 puffstage 7-9    86 white prepupae new    93 white prepupae 12hr  (218) white prepupae 24hr  (179) pupae 2d postWPP  (170) pupae 3d postWPP  (314) pupae 4d postWPP  (245) adult male 01day  (282) adult male 05day  (211) adult male 30day  (152) adult female 01day  (245) adult female 05day  102 adult female 30day  (114) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    4 embryo 04-06hr    6 embryo 06-08hr    21 embryo 08-10hr    33 embryo 10-12hr    96 embryo 12-14hr    106 embryo 14-16hr    414 embryo 16-18hr    613 embryo 18-20hr    994 embryo 20-22hr    650 embryo 22-24hr    492 larva L1    477 larva L2    492 larva L3 12hr old    701 larva L3 puffstage 1-2    204 larva L3 puffstage 3-6    141 larva L3 puffstage 7-9    86 white prepupae new    93 white prepupae 12hr    218 white prepupae 24hr    179 pupae 2d postWPP    170 pupae 3d postWPP    314 pupae 4d postWPP    245 adult male 01day    282 adult male 05day    211 adult male 30day    152 adult female 01day    245 adult female 05day    102 adult female 30day    114 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    4 embryo 04-06hr    6 embryo 06-08hr    21 embryo 08-10hr    33 embryo 10-12hr    96 embryo 12-14hr    106 embryo 14-16hr    414 embryo 16-18hr    613 embryo 18-20hr    994 embryo 20-22hr    650 embryo 22-24hr    492 larva L1    477 larva L2    492 larva L3 12hr old    701 larva L3 puffstage 1-2    204 larva L3 puffstage 3-6    141 larva L3 puffstage 7-9    86 white prepupae new    93 white prepupae 12hr    218 white prepupae 24hr    179 pupae 2d postWPP    170 pupae 3d postWPP    314 pupae 4d postWPP    245 adult male 01day    282 adult male 05day    211 adult male 30day    152 adult female 01day    245 adult female 05day    102 adult female 30day    114 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    4 embryo 04-06hr    6 embryo 06-08hr    21 embryo 08-10hr  (33) embryo 10-12hr  (96) embryo 12-14hr  (106) embryo 14-16hr  (414) embryo 16-18hr  (613) embryo 18-20hr  (994) embryo 20-22hr  (650) embryo 22-24hr  (492) larva L1  (477) larva L2  (492) larva L3 12hr old  (701) larva L3 puffstage 1-2  (204) larva L3 puffstage 3-6  (141) larva L3 puffstage 7-9  (86) white prepupae new  (93) white prepupae 12hr  (218) white prepupae 24hr  (179) pupae 2d postWPP  (170) pupae 3d postWPP  (314) pupae 4d postWPP  (245) adult male 01day  (282) adult male 05day  (211) adult male 30day  (152) adult female 01day  (245) adult female 05day  (102) adult female 30day  (114) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    4 embryo 04-06hr    6 embryo 06-08hr    21 embryo 08-10hr    33 embryo 10-12hr    96 embryo 12-14hr  106 embryo 14-16hr  (414) embryo 16-18hr  (613) embryo 18-20hr  (994) embryo 20-22hr  (650) embryo 22-24hr  (492) larva L1  (477) larva L2  (492) larva L3 12hr old  (701) larva L3 puffstage 1-2  (204) larva L3 puffstage 3-6  141 larva L3 puffstage 7-9    86 white prepupae new    93 white prepupae 12hr  (218) white prepupae 24hr  (179) pupae 2d postWPP  (170) pupae 3d postWPP  (314) pupae 4d postWPP  (245) adult male 01day  (282) adult male 05day  (211) adult male 30day  (152) adult female 01day  (245) adult female 05day  102 adult female 30day  114 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    4 embryo 04-06hr    6 embryo 06-08hr    21 embryo 08-10hr    33 embryo 10-12hr    96 embryo 12-14hr    106 embryo 14-16hr    414 embryo 16-18hr    613 embryo 18-20hr    994 embryo 20-22hr    650 embryo 22-24hr    492 larva L1    477 larva L2    492 larva L3 12hr old    701 larva L3 puffstage 1-2    204 larva L3 puffstage 3-6    141 larva L3 puffstage 7-9    86 white prepupae new    93 white prepupae 12hr    218 white prepupae 24hr    179 pupae 2d postWPP    170 pupae 3d postWPP    314 pupae 4d postWPP    245 adult male 01day    282 adult male 05day    211 adult male 30day    152 adult female 01day    245 adult female 05day    102 adult female 30day    114 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    5162 Schneider line 2 Sg4    3653 embryonic 1182-4H    4888 embryonic GM2    657 embryonic Kc167    687 embryonic S1    1348 embryonic S3    9825 leg disc CME L1    4864 wing disc CME-W2    1890 wing disc ML-DmD8    2908 wing disc ML-DmD9    5592 wing disc ML-DmD16-c3    3249 wing disc ML-DmD21    6155 wing disc ML-DmD32    4181 haltere disc ML-DmD17-c3    559 eye-antennal disc ML-DmD11    2994 antennal disc ML-DmD20-c5    1458 mixed discs ML-DmD4-c1    7938 CNS ML-DmBG1-c1    1781 CNS ML-DmBG2-c2    357 tumorous blood cells mbn2    4603 ovary fGS/OSS    1198 ovary OSC    149 ovary OSS    375 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (5162) Schneider line 2 Sg4  (3653) embryonic 1182-4H  (4888) embryonic GM2  (657) embryonic Kc167  (687) embryonic S1  (1348) embryonic S3  (9825) leg disc CME L1  (4864) wing disc CME-W2  (1890) wing disc ML-DmD8  (2908) wing disc ML-DmD9  (5592) wing disc ML-DmD16-c3  (3249) wing disc ML-DmD21  (6155) wing disc ML-DmD32  (4181) haltere disc ML-DmD17-c3  (559) eye-antennal disc ML-DmD11  (2994) antennal disc ML-DmD20-c5  (1458) mixed discs ML-DmD4-c1  (7938) CNS ML-DmBG1-c1  (1781) CNS ML-DmBG2-c2  (357) tumorous blood cells mbn2  (4603) ovary fGS/OSS  (1198) ovary OSC  (149) ovary OSS  (375) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (5162) Schneider line 2 Sg4  (3653) embryonic 1182-4H  (4888) embryonic GM2  (657) embryonic Kc167  (687) embryonic S1  (1348) embryonic S3  (9825) leg disc CME L1  (4864) wing disc CME-W2  (1890) wing disc ML-DmD8  (2908) wing disc ML-DmD9  (5592) wing disc ML-DmD16-c3  (3249) wing disc ML-DmD21  (6155) wing disc ML-DmD32  (4181) haltere disc ML-DmD17-c3  (559) eye-antennal disc ML-DmD11  (2994) antennal disc ML-DmD20-c5  (1458) mixed discs ML-DmD4-c1  (7938) CNS ML-DmBG1-c1  (1781) CNS ML-DmBG2-c2  (357) tumorous blood cells mbn2  (4603) ovary fGS/OSS  (1198) ovary OSC  (149) ovary OSS  (375) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    5162 Schneider line 2 Sg4    3653 embryonic 1182-4H    4888 embryonic GM2    657 embryonic Kc167    687 embryonic S1    1348 embryonic S3    9825 leg disc CME L1    4864 wing disc CME-W2    1890 wing disc ML-DmD8    2908 wing disc ML-DmD9    5592 wing disc ML-DmD16-c3    3249 wing disc ML-DmD21    6155 wing disc ML-DmD32    4181 haltere disc ML-DmD17-c3    559 eye-antennal disc ML-DmD11    2994 antennal disc ML-DmD20-c5    1458 mixed discs ML-DmD4-c1    7938 CNS ML-DmBG1-c1    1781 CNS ML-DmBG2-c2    357 tumorous blood cells mbn2    4603 ovary fGS/OSS    1198 ovary OSC    149 ovary OSS    375 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    5162 Schneider line 2 Sg4    3653 embryonic 1182-4H    4888 embryonic GM2    657 embryonic Kc167    687 embryonic S1    1348 embryonic S3    9825 leg disc CME L1    4864 wing disc CME-W2    1890 wing disc ML-DmD8    2908 wing disc ML-DmD9    5592 wing disc ML-DmD16-c3    3249 wing disc ML-DmD21    6155 wing disc ML-DmD32    4181 haltere disc ML-DmD17-c3    559 eye-antennal disc ML-DmD11    2994 antennal disc ML-DmD20-c5    1458 mixed discs ML-DmD4-c1    7938 CNS ML-DmBG1-c1    1781 CNS ML-DmBG2-c2    357 tumorous blood cells mbn2    4603 ovary fGS/OSS    1198 ovary OSC    149 ovary OSS    375 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (5162) Schneider line 2 Sg4  (3653) embryonic 1182-4H  (4888) embryonic GM2  (657) embryonic Kc167  (687) embryonic S1  (1348) embryonic S3  (9825) leg disc CME L1  (4864) wing disc CME-W2  (1890) wing disc ML-DmD8  (2908) wing disc ML-DmD9  (5592) wing disc ML-DmD16-c3  (3249) wing disc ML-DmD21  (6155) wing disc ML-DmD32  (4181) haltere disc ML-DmD17-c3  (559) eye-antennal disc ML-DmD11  (2994) antennal disc ML-DmD20-c5  (1458) mixed discs ML-DmD4-c1  (7938) CNS ML-DmBG1-c1  (1781) CNS ML-DmBG2-c2  (357) tumorous blood cells mbn2  (4603) ovary fGS/OSS  (1198) ovary OSC  (149) ovary OSS  (375) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (5162) Schneider line 2 Sg4  (3653) embryonic 1182-4H  (4888) embryonic GM2  (657) embryonic Kc167  (687) embryonic S1  (1348) embryonic S3  (9825) leg disc CME L1  (4864) wing disc CME-W2  (1890) wing disc ML-DmD8  (2908) wing disc ML-DmD9  (5592) wing disc ML-DmD16-c3  (3249) wing disc ML-DmD21  (6155) wing disc ML-DmD32  (4181) haltere disc ML-DmD17-c3  (559) eye-antennal disc ML-DmD11  (2994) antennal disc ML-DmD20-c5  (1458) mixed discs ML-DmD4-c1  (7938) CNS ML-DmBG1-c1  (1781) CNS ML-DmBG2-c2  (357) tumorous blood cells mbn2  (4603) ovary fGS/OSS  (1198) ovary OSC  (149) ovary OSS  (375) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    5162 Schneider line 2 Sg4    3653 embryonic 1182-4H    4888 embryonic GM2    657 embryonic Kc167    687 embryonic S1    1348 embryonic S3    9825 leg disc CME L1    4864 wing disc CME-W2    1890 wing disc ML-DmD8    2908 wing disc ML-DmD9    5592 wing disc ML-DmD16-c3    3249 wing disc ML-DmD21    6155 wing disc ML-DmD32    4181 haltere disc ML-DmD17-c3    559 eye-antennal disc ML-DmD11    2994 antennal disc ML-DmD20-c5    1458 mixed discs ML-DmD4-c1    7938 CNS ML-DmBG1-c1    1781 CNS ML-DmBG2-c2    357 tumorous blood cells mbn2    4603 ovary fGS/OSS    1198 ovary OSC    149 ovary OSS    375 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    109 cold shock, 4-day adult    92 heat shock, 4-day adult    260 Cadmium 50 mM 6 hrs, larvae L3    469 Cadmium 50 mM 12 hrs, larvae L3    206 Cadmium 50 mM 48 hrs, 4-day adult    272 Cadmium 100 mM 48 hrs, 4-day adult    45 Copper 0.5 mM 12 hrs, larvae L3    332 Copper 15 mM 48 hrs, 4-day adult    30 Zinc 5 mM 12 hrs, larvae L3    209 Zinc 4.5 mM 48 hrs, 4-day adult    81 Ethanol 2.5% 3 hrs, larvae L3    103 Ethanol 5% 3 hrs, larvae L3    394 Ethanol 10% 3 hrs, larvae L3    478 Caffeine 1.5 mg/ml 4 hrs, larvae L3    302 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    62 Caffeine 25 mg/ml 48 hrs, 4-day adult    86 Paraquat 5 mM 48 hrs, 4-day adult    122 Paraquat 10 mM 48 hrs, 4-day adult    123 Rotenone 2 μg 12 hrs, larvae L3    407 Rotenone 8 μg 12 hrs, larvae L3    621 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (109) cold shock, 4-day adult  (92) heat shock, 4-day adult  (260) Cadmium 50 mM 6 hrs, larvae L3  (469) Cadmium 50 mM 12 hrs, larvae L3  (206) Cadmium 50 mM 48 hrs, 4-day adult  (272) Cadmium 100 mM 48 hrs, 4-day adult  (45) Copper 0.5 mM 12 hrs, larvae L3  (332) Copper 15 mM 48 hrs, 4-day adult  (30) Zinc 5 mM 12 hrs, larvae L3  (209) Zinc 4.5 mM 48 hrs, 4-day adult  (81) Ethanol 2.5% 3 hrs, larvae L3  (103) Ethanol 5% 3 hrs, larvae L3  (394) Ethanol 10% 3 hrs, larvae L3  (478) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (302) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (62) Caffeine 25 mg/ml 48 hrs, 4-day adult  (86) Paraquat 5 mM 48 hrs, 4-day adult  (122) Paraquat 10 mM 48 hrs, 4-day adult  (123) Rotenone 2 μg 12 hrs, larvae L3  (407) Rotenone 8 μg 12 hrs, larvae L3  (621) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult  (109) cold shock, 4-day adult    92 heat shock, 4-day adult  (260) Cadmium 50 mM 6 hrs, larvae L3  (469) Cadmium 50 mM 12 hrs, larvae L3  (206) Cadmium 50 mM 48 hrs, 4-day adult  (272) Cadmium 100 mM 48 hrs, 4-day adult    45 Copper 0.5 mM 12 hrs, larvae L3  (332) Copper 15 mM 48 hrs, 4-day adult    30 Zinc 5 mM 12 hrs, larvae L3  (209) Zinc 4.5 mM 48 hrs, 4-day adult    81 Ethanol 2.5% 3 hrs, larvae L3  103 Ethanol 5% 3 hrs, larvae L3  (394) Ethanol 10% 3 hrs, larvae L3  (478) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (302) Caffeine 2.5 mg/ml 48 hrs, 4-day adult    62 Caffeine 25 mg/ml 48 hrs, 4-day adult    86 Paraquat 5 mM 48 hrs, 4-day adult  (122) Paraquat 10 mM 48 hrs, 4-day adult  (123) Rotenone 2 μg 12 hrs, larvae L3  (407) Rotenone 8 μg 12 hrs, larvae L3  (621) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    109 cold shock, 4-day adult    92 heat shock, 4-day adult    260 Cadmium 50 mM 6 hrs, larvae L3    469 Cadmium 50 mM 12 hrs, larvae L3    206 Cadmium 50 mM 48 hrs, 4-day adult    272 Cadmium 100 mM 48 hrs, 4-day adult    45 Copper 0.5 mM 12 hrs, larvae L3    332 Copper 15 mM 48 hrs, 4-day adult    30 Zinc 5 mM 12 hrs, larvae L3    209 Zinc 4.5 mM 48 hrs, 4-day adult    81 Ethanol 2.5% 3 hrs, larvae L3    103 Ethanol 5% 3 hrs, larvae L3    394 Ethanol 10% 3 hrs, larvae L3    478 Caffeine 1.5 mg/ml 4 hrs, larvae L3    302 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    62 Caffeine 25 mg/ml 48 hrs, 4-day adult    86 Paraquat 5 mM 48 hrs, 4-day adult    122 Paraquat 10 mM 48 hrs, 4-day adult    123 Rotenone 2 μg 12 hrs, larvae L3    407 Rotenone 8 μg 12 hrs, larvae L3    621 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    109 cold shock, 4-day adult    92 heat shock, 4-day adult    260 Cadmium 50 mM 6 hrs, larvae L3    469 Cadmium 50 mM 12 hrs, larvae L3    206 Cadmium 50 mM 48 hrs, 4-day adult    272 Cadmium 100 mM 48 hrs, 4-day adult    45 Copper 0.5 mM 12 hrs, larvae L3    332 Copper 15 mM 48 hrs, 4-day adult    30 Zinc 5 mM 12 hrs, larvae L3    209 Zinc 4.5 mM 48 hrs, 4-day adult    81 Ethanol 2.5% 3 hrs, larvae L3    103 Ethanol 5% 3 hrs, larvae L3    394 Ethanol 10% 3 hrs, larvae L3    478 Caffeine 1.5 mg/ml 4 hrs, larvae L3    302 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    62 Caffeine 25 mg/ml 48 hrs, 4-day adult    86 Paraquat 5 mM 48 hrs, 4-day adult    122 Paraquat 10 mM 48 hrs, 4-day adult    123 Rotenone 2 μg 12 hrs, larvae L3    407 Rotenone 8 μg 12 hrs, larvae L3    621 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (109) cold shock, 4-day adult  (92) heat shock, 4-day adult  (260) Cadmium 50 mM 6 hrs, larvae L3  (469) Cadmium 50 mM 12 hrs, larvae L3  (206) Cadmium 50 mM 48 hrs, 4-day adult  (272) Cadmium 100 mM 48 hrs, 4-day adult  (45) Copper 0.5 mM 12 hrs, larvae L3  (332) Copper 15 mM 48 hrs, 4-day adult  30 Zinc 5 mM 12 hrs, larvae L3  (209) Zinc 4.5 mM 48 hrs, 4-day adult  (81) Ethanol 2.5% 3 hrs, larvae L3  (103) Ethanol 5% 3 hrs, larvae L3  (394) Ethanol 10% 3 hrs, larvae L3  (478) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (302) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (62) Caffeine 25 mg/ml 48 hrs, 4-day adult  (86) Paraquat 5 mM 48 hrs, 4-day adult  (122) Paraquat 10 mM 48 hrs, 4-day adult  (123) Rotenone 2 μg 12 hrs, larvae L3  (407) Rotenone 8 μg 12 hrs, larvae L3  (621) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult  109 cold shock, 4-day adult    92 heat shock, 4-day adult  (260) Cadmium 50 mM 6 hrs, larvae L3  (469) Cadmium 50 mM 12 hrs, larvae L3  (206) Cadmium 50 mM 48 hrs, 4-day adult  (272) Cadmium 100 mM 48 hrs, 4-day adult    45 Copper 0.5 mM 12 hrs, larvae L3  (332) Copper 15 mM 48 hrs, 4-day adult    30 Zinc 5 mM 12 hrs, larvae L3  (209) Zinc 4.5 mM 48 hrs, 4-day adult    81 Ethanol 2.5% 3 hrs, larvae L3  103 Ethanol 5% 3 hrs, larvae L3  (394) Ethanol 10% 3 hrs, larvae L3  (478) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (302) Caffeine 2.5 mg/ml 48 hrs, 4-day adult    62 Caffeine 25 mg/ml 48 hrs, 4-day adult    86 Paraquat 5 mM 48 hrs, 4-day adult  122 Paraquat 10 mM 48 hrs, 4-day adult  123 Rotenone 2 μg 12 hrs, larvae L3  (407) Rotenone 8 μg 12 hrs, larvae L3  (621) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    109 cold shock, 4-day adult    92 heat shock, 4-day adult    260 Cadmium 50 mM 6 hrs, larvae L3    469 Cadmium 50 mM 12 hrs, larvae L3    206 Cadmium 50 mM 48 hrs, 4-day adult    272 Cadmium 100 mM 48 hrs, 4-day adult    45 Copper 0.5 mM 12 hrs, larvae L3    332 Copper 15 mM 48 hrs, 4-day adult    30 Zinc 5 mM 12 hrs, larvae L3    209 Zinc 4.5 mM 48 hrs, 4-day adult    81 Ethanol 2.5% 3 hrs, larvae L3    103 Ethanol 5% 3 hrs, larvae L3    394 Ethanol 10% 3 hrs, larvae L3    478 Caffeine 1.5 mg/ml 4 hrs, larvae L3    302 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    62 Caffeine 25 mg/ml 48 hrs, 4-day adult    86 Paraquat 5 mM 48 hrs, 4-day adult    122 Paraquat 10 mM 48 hrs, 4-day adult    123 Rotenone 2 μg 12 hrs, larvae L3    407 Rotenone 8 μg 12 hrs, larvae L3    621 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_18 mE1_20_mRNA_expression_cluster_10
External Data & Images
Linkouts	BDGP expression data • RH45818 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0026562 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6378-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for BM-40-SPARC Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal BM-40-SPARCnm136 viable, with Scer\GAL4pnr-MD237 BM-40-SPARCGD5660 Phenotype manifest in Allele embryonic/first instar larval cuticle BM-40-SPARCnm136 presumptive embryonic/larval tracheal system BM-40-SPARCnm136 ventral nerve cord | embryonic stage BM-40-SPARCnm136
Classical Alleles ( 3 )
For All Classical Alleles Show
Allele of BM-40-SPARC Class Mutagen Stocks Known lesion BM-40-SPARCMI00329 1 Yes BM-40-SPARCMI00329-GAL4 site specific recombinase 0 Yes BM-40-SPARCnm136 Delta2-3 0 Yes
Alleles Carried on Transgenic Constructs ( 22 )
For All Alleles Carried on Transgenic Constructs Show
Allele of BM-40-SPARC Class Mutagen Stocks Known lesion BM-40-SPARCGD5660 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes BM-40-SPARCHMS02133 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes BM-40-SPARCKK108185 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes BM-40-SPARC+1nt.MtnA.T:Avic\GFP-EGFP in vitro construct - site directed mutagenesis 0 Yes BM-40-SPARC+2nt.MtnA.T:Avic\GFP-EGFP in vitro construct - site directed mutagenesis 0 Yes BM-40-SPARC+3nt.63.MtnA.T:Avic\GFP-EGFP in vitro construct - site directed mutagenesis 0 Yes BM-40-SPARC+3nt.88.MtnA.T:Avic\GFP-EGFP in vitro construct - site directed mutagenesis 0 Yes BM-40-SPARCchgmut1.MtnA.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 -- BM-40-SPARCchgmut1.MtnA.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes BM-40-SPARCchgmut2.MtnA.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 -- BM-40-SPARCchgmut2.MtnA.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes BM-40-SPARCdsRNA.cRa in vitro construct - RNAi 0 Yes BM-40-SPARCMtnA.PH in vitro construct - regulatory fusion 0 Yes BM-40-SPARCNIG.6378R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes BM-40-SPARCScer\UAS.cMa in vitro construct - regulatory fusion 0 Yes BM-40-SPARCsilmut.MtnA.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes BM-40-SPARCΔ1-40.BiPss.MtnA in vitro construct - regulatory fusion in vitro construct - deletion in vitro construct - coding region fusion 0 Yes BM-40-SPARCΔ1-40.MtnA in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes BM-40-SPARCΔ139-304.MtnA.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes BM-40-SPARCΔ139-304.MtnA in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes BM-40-SPARCΔ41-138.MtnA in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes BM-40-SPARCΔ84-304.MtnA in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes
Aneuploid Aberrations
Partially disrupted in	Df(3R)nm136 (Martinek et al., 2008)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD5660} NA P{KK108185} NA P{NIG.6378R} NA P{TRiP.HMS02133} NA P{UAS-SPARC.M} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{GT-GAL4}BM-40-SPARCMI00329-GAL4 NA Mi{MIC}BM-40-SPARCMI00329 NA
Gene Ontology: Function, Process & Cellular Component ( 12 unique terms )
Terms Based on Experimental Evidence ( 6 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
anterior Malpighian tubule development inferred from mutant phenotype (Bunt et al., 2010) extracellular matrix constituent secretion inferred from mutant phenotype (Martinek et al., 2008) Malpighian tubule morphogenesis inferred from mutant phenotype (Bunt et al., 2010) mesoderm development inferred from expression pattern (Furlong et al., 2001) trachea development inferred from mutant phenotype (Martinek et al., 2008) ventral cord development inferred from mutant phenotype (Martinek et al., 2008)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
calcium ion binding inferred from electronic annotation with InterPro:IPR011992, InterPro:IPR019577 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
cell adhesion inferred from sequence or structural similarity (Hynes and Zhao, 2000) signal transduction inferred from electronic annotation with InterPro:IPR019577 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
basement membrane non-traceable author statement (Kohfeldt, 1999.3.16, FlyBase, 1992-) extracellular space inferred from electronic annotation with InterPro:IPR001999 (FlyBase Curators et al., 2004-) proteinaceous extracellular matrix inferred from electronic annotation with InterPro:IPR019577 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Hynes and Zhao, 2000)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions BM-40-SPARC allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 68121 DroID - A comprehensive database of gene and protein interactions. • FBgn0026562 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43230
Orthologs
OrthoDB Orthologs (42) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG680JGV Dipteran inclusive ortholog search EOG6NP7CB Insect inclusive ortholog search EOG6B8H8X Arthropod inclusive ortholog search EOG6DR7V4 Metazoa inclusive ortholog search EOG6V4G30
Orthologs in Drosophila Species (EOG680JGV)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\BM-40-SPARC     Drosophila simulans   Dsim\GD18115 Y   Drosophila sechellia   Dsec\GM10161 Y   Drosophila erecta   Dere\GG12168 Y   Drosophila yakuba   Dyak\BM-40-SPARC Y   Drosophila ananassae   Dana\GF18564 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA19550 Y   Drosophila persimilis   Dper\GL27264 Y   Drosophila willistoni   Dwil\GK13743 Y   Drosophila mojavensis   Dmoj\GI24525 Y   Drosophila grimshawi   Dgri\GH23669 Y
Orthologs in non-Drosophila Dipterans (EOG6NP7CB)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL013656   Anopheles gambiae Malaria mosquito  Agam\AGAP000305   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ005566
Orthologs in non-Dipteran Insects (EOG6B8H8X)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\BM-40-SPARC   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG013906   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH26762   Atta cephalotes Leafcutter ant  Acep\ACEP15543   Camponotus floridanus Florida carpenter ant  Cflo\CFLO16399   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL28496   Linepithema humile Argentine ant  Lhum\LH24912   Pogonomyrmex barbatus Red harvester ant  Pbar\PB16282   Solenopsis invicta Red fire ant  Sinv\SINV14625   Acyrthosiphon pisum Pea aphid  Apim\ACYPI001359   Bombyx mori Silkmoth  Bmor\SPARC   Pediculus humanus Human body louse  Phum\PHUM407560   Tribolium castaneum Red flour beetle  Tcas\TC000930
Orthologs in non-Insect Arthropods (EOG6DR7V4)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\l(3)73Ah   Ixodes scapularis Deer tick  Isca\ISCW022231
Orthologs in non-Arthropod Metazoa (EOG6V4G30)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\ost-1   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_028275gn   Danio rerio Zebrafish  Drer\sparc   Danio rerio Zebrafish  Drer\sparcl1   Xenopus tropicalis Western clawed frog  Xtro\sparc   Gallus gallus Domestic chicken  Ggal\SPARCL1   Gallus gallus Domestic chicken  Ggal\SPARC   Mus musculus House mouse  Mmus\Sparcl1   Mus musculus House mouse  Mmus\Sparc   Rattus norvegicus Norway rat  Rnor\Sparcl1   Rattus norvegicus Norway rat  Rnor\Sparc   Homo sapiens Human  Hsap\SPARCL1   Homo sapiens Human  Hsap\SPARC
Human Orthologs (2)
Gene OMIM HGNC Hsap\SPARCL1     Hsap\SPARC
AAA Orthologs (10) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD18115 Drosophila sechellia Dsec\GM10161 Drosophila erecta Dere\GG12168 Drosophila yakuba Dyak\BM-40-SPARC Drosophila ananassae Dana\GF18564 Drosophila pseudoobscura pseudoobscura Dpse\GA19550 Drosophila persimilis Dper\GL27264 Drosophila willistoni Dwil\GK13743 Drosophila mojavensis Dmoj\GI24525 Drosophila grimshawi Dgri\GH23669
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	40885 y1 v1; P{TRiP.HMS02133}attP40 30711 y1 w*; Mi{MIC}BM-40-SPARCMI00329/TM6B, Tb1
VDRC	v100566 P{KK108185}VIE-260B v16677 w1118; P{GD5660}v16677 v16678 w1118; P{GD5660}v16678
Genomic Clones ( 1 )
	BACR24O14 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 247 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RH45818
Other clones	AF171872 MIP10412 yak-ad_BM
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH02045 GH02145 GH02251 GH03735 GH07448 GH07839 GH10591 GH11103 GH12416 GH12486 GH12505 GH14461 GH15031 GH15085 GH15268 GH17484 GH20808 GH21093 GH21692 GH23264 GH23595 GH24642 GH24675 GH26410 GH26984 GM02366 GM13178 GM19730 GM20620 GM22141 GM23279 GM24532 GM30669 LD38276 LP03083 LP03445 LP12045 LP13579 LP15308 LP15482 LP16774 RE01661 RE26011 RE26417 RE29878 RE40622 RE50202 RE52146 RE56132 RE58244 RE58645 RE61224 RH03773 RH14315 RH20141 RH22411 RH23081 RH23508 RH34042 RH35088 RH50343 RH51723 RH55204 RH55289 RH57239 RH63596 RH66884 RH70038 RH71884 SD01754 SD02348 SD04511 SD04921 SD07323 SD07968 SD10463 SD10562 SD11203 SD11843 SD11968 SD12238 SD12605 SD13013 SD13083 SD13353 SD14731 SD14880 SD14907 SD14926 SD14934 SD15057 SD15194 SD15518 SD15790 SD16812 SD16913 SD17079 SD17089 SD17478 SD18058 SD18537 SD19389 SD19553 SD20952 SD23919 SD25257 SD26010 SD26143 SD27817 SD27885 SD27886
Other clones	62586 66793 72294 108728 149305 162702 214441.16 522199 522205 522581 522796 523879 524961 525763 525790 527047 527146 527935 533560 533861 542642 556937 556974 557055 568975 569000 569506 569621 569759 569837 571170 575634 576499 CK01.5B.C7 CK01.75D.F12 CK01.83A.C5 EC35239 EK011132 EK059256 EK066311 EK187832 EK195054 EK200859 EK235152 EK254411 EK266937 EN00609 EN01540 EN01546 EN02410 EN02819 EN04351 EN06246 EN07160 EN07345 EN08057 EN09743 EN10315 EN11026 EN11726 EN11764 EN11937 EN13001 EN14261 EN14333 EN15029 EN15254 EN15540 EN15721 EN16244 EN16402 EN17402 EN17448 EN17810 EP09833 FGH115C07 FGM105B12 IP05239 IP10604 IP10704 IP11708 IP12441 IP12541 IP12641 IP17125 RP003039599 RP003051214 RP003058325 RP003064024 RP003105519 RP003109724 RP003113238 RP003114821 RP003119521 RP003144480 RP003157756 RP003165710 RP003168370 RP003168788 RP003168992 RP003171371 RP003172493 RP003214970 RP003237757 RP003241991 RP003276528 RP003277886 RP003286384 RP003303132 RP003315962 RP003316262 RP003335035 RP003344729 RP003353204 RP003353313 RP003374642 RP003471562 RP003474556 RP003475662 RP003522226 RP003531951 RP003544086 RP003547430 RP003602189 RP003603310 RP003607243 RP003641082 RP003661699 RP003663236 RP003674142 UT01093 UT01260
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0026562 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43230
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: BM-40/SPARC anon-EST:Posey291 (Bayraktaroglu, 2000.11.2)
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_143252 NM_001276069 RefSeq (Proteins) • NP_651509 NP_001262998 DDBJ / EMBL / GenBank • AA695181 AAF56632 AAL49360 AF171872 AGB96378 AJ133736 AY071738 BI615918 CAB39319 Entrez Gene - A searchable database of RefSeq genes. • 43230 UniProtKB/TrEMBL • O97365 Q8SY75
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Osteonectin-like, conserved site (IPR001999) EF-hand-like domain (IPR011992) EF-Hand 1, calcium-binding site (IPR018247) Follistatin-like, N-terminal (IPR003645) SPARC/Testican, calcium-binding domain (IPR019577) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • RH45818
Linkouts
	BioGRID - A database of protein and genetic interactions • 68121 DroID - A comprehensive database of gene and protein interactions. • FBgn0026562 DRSC - Results from RNAi screens. • FBgn0026562 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0026562 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6378-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0026562 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43230 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43230 modMine - Data generated by the modENCODE project. • FBgn0026562
Synonyms & Secondary IDs ( 11 )
Reported As
Symbol Synonym	anon-EST:Posey291   BM40 (Eble et al., 2001) BM-40/SPARC (Butler et al., 2003, Egger et al., 2002, Loop et al., 2004) BM-40-SPARC (Hollien and Weissman, 2006, Venken et al., 2011, Venken et al., 2011, Butchar et al., 2012, Cherbas et al., 2011, Japanese National Institute of Genetics, 2012.5.21, Fu and Whitfield, 2012) BM-40 Sparc (Rehwinkel et al., 2004) CG6378 (Furlong et al., 2001, Roos et al., 2005, Hollien and Weissman, 2006, Mosallanejad et al., 2010, Keleman et al., 2009.8.5, Portela et al., 2010, Ni et al., 2010.12.1) CT19876 (Hynes and Zhao, 2000, Hynes and Zhao, 2000) dsparc (Martinek and Ringuette, 2004, Martinek et al., 2008, Bunt et al., 2010, Portela et al., 2010) dSPARC (Martinek et al., 2002) SPARC (Martinek et al., 2002, Martinek et al., 2001, Martinek et al., 2000, Hollien and Weissman, 2006, Pastor-Pareja and Xu, 2011, Martinek et al., 2008, Junion et al., 2007)
Name Synonym	BM-40-SPARC   Osteonectin (Banyai and Patthy, 2004)
Secondary FlyBase IDs
	FBgn0027691
References ( 48 )
Generate a list of	All references relating to this gene ( 48 )
List References by type	Research paper  ( 21 ) Supplementary material  ( 7 ) Review  ( 2 ) Personal communication to FlyBase  ( 7 ) Abstract  ( 4 ) FlyBase analysis  ( 1 ) Stock list  ( 1 ) DNA/RNA sequence record  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 5 )
	Butchar et al., 2012, Genetics 191(4): 1213--1226 New negative feedback regulators of egfr signaling in Drosophila. [FBrf0219175] Fu and Whitfield, 2012, PLoS ONE 7(5): e29157 Genes associated with honey bee behavioral maturation affect clock-dependent and -independent aspects of daily rhythmic activity in fruit flies. [FBrf0218339] Cherbas et al., 2011, Genome Res. 21(2): 301--314 The transcriptional diversity of 25 Drosophila cell lines. [FBrf0213077] Pastor-Pareja and Xu, 2011, Dev. Cell 21(2): 245--256 Shaping Cells and Organs in Drosophila by Opposing Roles of Fat Body-Secreted Collagen IV and Perlecan. [FBrf0214668] Venken et al., 2011, Nat. Methods 8(9): 737--743 MiMIC: a highly versatile transposon insertion resource for engineering Drosophila melanogaster genes. [FBrf0216331] Show all research papers ...
Recent reviews ( 1 )
	Broadie et al., 2011, Dev. Neurobiol. 71(11): 1102--1130 Extracellular matrix and its receptors in drosophila neural development. [FBrf0216377] Show all reviews ...