FB2021_01, released Feb 18, 2021

Gene: Dmel\Fie

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General Information
Symbol
Dmel\Fie
Species
D. melanogaster
Name
Fire exit
Annotation Symbol
CG1079
Feature Type
protein_coding_gene
FlyBase ID
FBgn0026592
Gene Model Status
Current
Stock Availability
9 publicly available
Gene Snapshot
Fire exit (Fie) is expressed in some peripheral glia cells and encodes a transmembrane protein that may be involved in intracellular transport during glial development. [Date last reviewed: 2019-08-01]
Other Summaries
Key Links
Genomic Location
Cytogenetic map
63F5-63F5
Sequence location
3L:3,892,574..3,894,833 [+]
Recombination map

3-9

RefSeq locus
NT_037436 REGION:3892574..3894833
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (1 term)
Molecular Function (0 terms)
There is no information supporting a Molecular Function term for this gene. (Based on a review of available data on: 2012-06-07 )
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
located_in integral component of membrane
inferred from sequence model
(Deligiannaki et al., 2015, With et al., 2003)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
PASIFLORA PROTEINS -
The Pasiflora protein family are a subgroup of the tetraspan superfamily, sharing the characteristic topology - four transmembrane domains and intracellular N- and C-termini. (Adapted from FBrf0229485).
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Fie for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.44

Gene model reviewed during 5.46

Gene model reviewed during 5.56

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Fie-RA
FBtr0073157
NM_133165
1600
250
Fie-RB
FBtr0333140
NM_001274452
1443
250
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Fie-PA
FBpp0073015
28.2
250
8.09
NP_573393
AAF47802
Fie-PB
FBpp0305346
28.2
250
8.09
NP_001261381
AGB94076
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

250 aa isoforms: Fie-PA, Fie-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Fie using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Fie in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 17 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Fie
Transgenic constructs containing regulatory region of Fie
Aberrations (Deficiencies and Duplications) ( 3 )
Inferred from experimentation
Gene disrupted in
Df(3L)Exel6098
(Ryder, 2004.4.26)
Df(3L)rQ286Δ73b
(With et al., 2003)
Df(3L)Y15Δ7b
(With et al., 2003)
Inferred from location
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (0)
No records found.
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (0)
No records found.
Rattus norvegicus (Norway rat) (0)
No records found.
Xenopus tropicalis (Western clawed frog) (0)
No records found.
Danio rerio (Zebrafish) (0)
No records found.
Caenorhabditis elegans (Nematode, roundworm) (0)
No records found.
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190DM9 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00007546
Drosophila simulans
Dsim\GD17625
Drosophila sechellia
Dsec\GM14595
Drosophila erecta
Dere\GG15166
Drosophila yakuba
Dyak\GE21385
Drosophila ananassae
Dana\GF24229
Drosophila pseudoobscura pseudoobscura
Dpse\GA10560
Drosophila persimilis
Dper\GL22361
Drosophila willistoni
Dwil\GK20530
Drosophila virilis
Dvir\GJ12420
Drosophila mojavensis
Dmoj\GI12515
Drosophila grimshawi
Dgri\GH16431
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150B8U )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17017889
Glossina morsitans
Tsetse fly
Gmor\GMOY008000
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_13267
Mayetiola destructor
Hessian fly
Mdes\Mdes007133
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL008826
Anopheles darlingi
American malaria mosquito
Adar\ADAC002092
Anopheles gambiae
Malaria mosquito
Agam\AGAP002039
Anopheles gambiae
Malaria mosquito
Agam\AGAP012803
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ002019
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ019529
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0DJG )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA007022
Danaus plexippus
Monarch butterfly
Dple\DPOGS205891-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL005572
Apis florea
Little honeybee
Aflo\2924555428
Apis mellifera
Western honey bee
Amel\GB49830
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP24167
Bombus terrestris
Buff-tailed bumblebee
Bter\15206883
Linepithema humile
Argentine ant
Lhum\LH20468
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000f50
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG027361
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG022001
Tribolium castaneum
Red flour beetle
Tcas\TC032908
Tribolium castaneum
Red flour beetle
Tcas\TC033938
Tribolium castaneum
Red flour beetle
Tcas\TC032907
Tribolium castaneum
Red flour beetle
Tcas\TC014088
Pediculus humanus
Human body louse
Phum\PHUM094840
Rhodnius prolixus
Kissing bug
Rpro\RPRC003189
Rhodnius prolixus
Kissing bug
Rpro\RPRC009072
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_10207
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_10211
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_13105
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0DH5 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR009853
Strigamia maritima
European centipede
Smar\SMAR010430
Strigamia maritima
European centipede
Smar\SMAR001792
Tetranychus urticae
Two-spotted spider mite
Turt\tetur01g09800
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
No non-Arthropod Metazoa orthologies identified
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (0)
No records found.
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser
    View in Interactions Browser
    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    Fie - CG14715
    experimental knowledge based
    (Guruharsha et al., 2011)
    Fie - Nlp
    experimental knowledge based
    (Guruharsha et al., 2011)
    Summary of Genetic Interactions
    esyN Network Diagram
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    DroID - A comprehensive database of gene and protein interactions.
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    External Data
    Linkouts
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3L
    Recombination map

    3-9

    Cytogenetic map
    63F5-63F5
    Sequence location
    3L:3,892,574..3,894,833 [+]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    63F5-63F5
    Limits computationally determined from genome sequence between P{PZ}kst01318 and P{PZ}Sc205634
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    Experimentally Determined Recombination Data
    Location

    3-9

    (FlyBase, 2016)

    3-8.0

    (Comeron et al., 2012)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (9)
    Genomic Clones (14)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (32)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    BDGP DGC clones
    Other clones
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
     
    Commercially Available Antibodies
     
    Other Information
    Relationship to Other Genes
    Source for database identify of
    Source for database merge of

    Source for merge of: BEST:HL04053 CG1079

    (Bayraktaroglu, 2000.11.2)
    Additional comments
    Other Comments

    Mutants have no obvious disruption to glial function in the embryo.

    (With et al., 2003)

    snRNA:U11 maps in intron 1 of CG1079, but is transcribed in the opposite orientation.

    (Yuan et al., 2003)
    Origin and Etymology
    Discoverer
    Etymology

    The gene is named "Fire exit" as the glia that express it do so during a time when they mark the entry and exit point of axons at the central nervous system/peripheral nervous system boundary.

    (With et al., 2003)
    Identification
    External Crossreferences and Linkouts ( 35 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
    Other crossreferences
    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    Flygut - An atlas of the Drosophila adult midgut
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    InterPro - A database of protein families, domains and functional sites
    KEGG Genes - Molecular building blocks of life in the genomic space.
    modMine - A data warehouse for the modENCODE project
    Linkouts
    DPiM - Drosophila Protein interaction map
    DroID - A comprehensive database of gene and protein interactions.
    DRSC - Results frm RNAi screens
    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
    FlyMine - An integrated database for Drosophila genomics
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Synonyms and Secondary IDs (6)
    Datasets (0)
    Study focus (0)
    Experimental Role
    Project
    Project Type
    Title
    References (32)