FlyBase Gene Report: Dmel\Axn

General Information

Symbol

Dmel\Axn

Species

D. melanogaster

Name

Axin

Annotation Symbol

CG7926

Feature Type

protein_coding_gene

FlyBase ID

FBgn0026597

Gene Model Status

Current

Stock Availability

12 publicly available

Gene Summary

Axin (Axn) encodes the key scaffolding protein for the canonical Wnt signalling pathway. In the absence of signal, it targets the product of arm for proteolysis inhibiting Wnt signalling. In the presence of signal, it forms a part of the membrane activation complex, disrupting the product of arm degradation. This pathway play roles in cell proliferation (imaginal disc), differentiation (embryonic patterning), death and stemness. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Pathway
Gene Group
UniProtKB
Interactive Fly

Also Known As

Daxin, d-axin, GSK3β, l(3)S044230, APC

Key Links

Genomic Location

Cytogenetic map

99D2-99D3

Sequence location

3R:30,022,842..30,035,311 [+]

Recombination map

3-100

RefSeq locus

NT_033777 REGION:30022842..30035311

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (23 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

enables beta-catenin binding

inferred from direct assay

(Hamada et al., 1999)

inferred from physical interaction with FLYBASE:arm; FB:FBgn0000117

(Kremer et al., 2010)

enables molecular adaptor activity

inferred from genetic interaction with FLYBASE:sgg; FB:FBgn0003371, FLYBASE:CkIα; FB:FBgn0015024

(Matsubayashi et al., 2004)

enables protein kinase binding

inferred from physical interaction with FLYBASE:sgg; FB:FBgn0003371

(Kremer et al., 2010)

enables signaling receptor binding

inferred from physical interaction with FLYBASE:arr; FB:FBgn0000119

(Yang et al., 2016)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (14 terms)

Terms Based on Experimental Evidence (14 terms)

CV Term

Evidence

References

involved_in chitin-based larval cuticle pattern formation

inferred from mutant phenotype

(Mendoza-Topaz et al., 2011, Peterson-Nedry et al., 2008, Willert et al., 1999)

involved_in dorsal/ventral pattern formation, imaginal disc

inferred from mutant phenotype

(Mendoza-Topaz et al., 2011)

involved_in eye-antennal disc morphogenesis

inferred from mutant phenotype

(Lee and Treisman, 2001)

acts_upstream_of glycogen metabolic process

inferred from mutant phenotype

(Yamazaki and Yanagawa, 2003)

involved_in heart development

inferred from mutant phenotype

(Casad et al., 2012)

involved_in imaginal disc-derived wing margin morphogenesis

inferred from mutant phenotype

(Willert et al., 1999)

involved_in negative regulation of canonical Wnt signaling pathway

inferred from mutant phenotype

(Schaefer et al., 2020, Tacchelly-Benites et al., 2018, Vuong et al., 2018, Croy et al., 2016, Wang et al., 2016, Roberts et al., 2011, Swarup and Verheyen, 2011, Peterson-Nedry et al., 2008, Matsubayashi et al., 2004, Yamazaki and Yanagawa, 2003, Hamada et al., 1999, Willert et al., 1999)

inferred from genetic interaction with FLYBASE:pan; FB:FBgn0085432

(Lee and Treisman, 2001)

inferred from direct assay

(Lybrand et al., 2019, Hendriksen et al., 2005, Yanagawa et al., 2000)

inferred from genetic interaction with FLYBASE:Apc; FB:FBgn0015589, FLYBASE:Apc2; FB:FBgn0026598

(Mendoza-Topaz et al., 2011)

inferred from genetic interaction with FLYBASE:Wnt2; FB:FBgn0004360

(Willert et al., 1999)

involved_in oogenesis

inferred from mutant phenotype

(Song and Xie, 2003)

involved_in ovarian follicle cell development

inferred from mutant phenotype

(Dai et al., 2017)

involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process

inferred from mutant phenotype

(Roberts et al., 2011)

involved_in regulation of cell death

inferred from genetic interaction with FLYBASE:Rbf; FB:FBgn0015799

(Zhang et al., 2014)

involved_in response to starvation

inferred from mutant phenotype

(Zhang et al., 2014)

involved_in segment polarity determination

inferred from mutant phenotype

(Mendoza-Topaz et al., 2011, Peterson-Nedry et al., 2008, Willert et al., 1999)

involved_in somatic stem cell population maintenance

inferred from mutant phenotype

(Song and Xie, 2003)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (5 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

part_of beta-catenin destruction complex

inferred from direct assay

(Lybrand et al., 2019, Mendoza-Topaz et al., 2011)

located_in cytoplasm

inferred from direct assay

(Fiedler et al., 2011, Cong and Varmus, 2004)

located_in cytosol

inferred from direct assay

(Lybrand et al., 2019)

located_in plasma membrane

inferred from direct assay

(Fiedler et al., 2011)

part_of Wnt signalosome

inferred from direct assay

(Yamazaki and Yanagawa, 2003)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

BETA CATENIN DESTRUCTION COMPLEX

Pathway (FlyBase)

Negative Regulators of Wnt-TCF Signaling Pathway

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Pathway (FlyBase)

Negative Regulators of Wnt-TCF Signaling Pathway -: Negative regulators of Wnt-TCF (canonical Wnt) signaling down-regulate the pathway, resulting in the attenuation of transcriptional regulation mediated by β-catenin (arm).

Gene Group (FlyBase)

BETA CATENIN DESTRUCTION COMPLEX -: The β-catenin destruction complex is a cytoplasmic protein complex that phosphorylates β-catenin, targeting it for ubiquitin-mediated proteolysis. In the absence of Wnt signaling, the β-catenin destruction complex constitutively suppresses the canonical Wnt signaling pathway by preventing the accumulation of cytoplasmic β-catenin (arm). (Adapted from FBrf0217546).

Protein Function (UniProtKB)

Inhibitor of the WG signaling pathway. Down-regulates beta-catenin (armadillo=ARM). Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B (zeste-white 3=ZW3).

(UniProt, Q9V407)

Summary (Interactive Fly)

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Axn for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Gene model reviewed during 5.47

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Axn-RA

FBtr0085553

NM_170457

4691

745

Axn-RB

FBtr0085555

NM_170458

3638

745

Axn-RC

FBtr0085554

NM_170459

4281

739

Axn-RD

FBtr0290030

NM_001144654

4553

699

Axn-RE

FBtr0300600

NM_001170302

3578

110

Axn-RF

FBtr0334702

NM_001276168

4535

693

Axn-RG

FBtr0334703

NM_001276169

3620

739

Additional Transcript Data and Comments

Reported size (kB)

2.232 (longest cDNA)

(Hamada et al., 1999)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Axn-PA

FBpp0084919

81.7

745

8.05

NP_733336

AAF56993

Axn-PB

FBpp0084921

81.7

745

8.05

NP_733337

AAN14207

Axn-PC

FBpp0084920

81.2

739

7.91

NP_733338

AAN14208

Axn-PD

FBpp0288469

76.9

699

8.22

NP_001138126

ACL83582

Axn-PE

FBpp0289827

12.5

110

6.10

NP_001163773

ACZ95067

Axn-PF

FBpp0306757

76.3

693

8.09

NP_001263097

AGB96476

Axn-PG

FBpp0306758

81.2

739

7.91

NP_001263098

AGB96477

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

745 aa isoforms: Axn-PA, Axn-PB

739 aa isoforms: Axn-PC, Axn-PG

Additional Polypeptide Data and Comments

Reported size (kDa)

743 (aa)

(Hamada et al., 1999)

Comments

External Data

Subunit Structure (UniProtKB)

Interacts with ZW3 and ARM. The interaction between AXN and ARM occurs via the armadillo repeats contained in ARM.

(UniProt, Q9V407)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Axn using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Axn_1
Axn_2

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage -- adult stage

(Hamada et al., 1999)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

western blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

(Willert et al., 1999)

Additional Descriptive Data

Axn protein is detected in embryos from 0-1hr until 11-12hr. The lowest levels are seen at the earliest time points and increasing amounts are seen with developmental time.

(Willert et al., 1999)

Marker for

Subcellular Localization

CV Term

Evidence

References

part_of beta-catenin destruction complex

inferred from direct assay

(Lybrand et al., 2019, Mendoza-Topaz et al., 2011)

located_in cytoplasm

inferred from direct assay

(Fiedler et al., 2011, Cong and Varmus, 2004)

located_in cytosol

inferred from direct assay

(Lybrand et al., 2019)

located_in plasma membrane

inferred from direct assay

(Fiedler et al., 2011)

part_of Wnt signalosome

inferred from direct assay

(Yamazaki and Yanagawa, 2003)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Axn in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Axn

View exonic expression by tissue for Dmel\Axn

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0026597

DRscDB

43565/tissue=All

EMBL-EBI Single Cell Expression Atlas

FBgn0026597

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG7926-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG7926

Flygut - An atlas of the Drosophila adult midgut

FBgn0026597

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 18 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 67 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Axn

Transgenic constructs containing regulatory region of Axn

Aberrations (Deficiencies and Duplications) ( 4 )

Inferred from experimentation ( 4 )

Gene disrupted in

Df(3R)B81

(Szeged Stock Center, 1998-)

Df(3R)X3F

(Cook, 2006.1.31)

Gene not disrupted in

Df(3R)01215

(Cook, 2006.1.31)

Df(3R)L127

(Szeged Stock Center, 1998-)

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal

lethal, with Axn^{K446E.αTub84B.Tag:FLAG}

Axn^S044230

lethal, with Axn^{L501P.αTub84B.Tag:FLAG}

Axn^S044230

lethal, with Axn^S044230

lethal (with Axn¹⁵¹¹)

Axn^S044230

lethal (with Axn^S044230)

Axn¹⁵¹¹

lethal | heat sensitive

Axn^{V72R.I169R.L170R.KI}

lethal | maternal effect, with Axn^{H504L.αTub84B.Tag:FLAG}

Axn^S044230

lethal | maternal effect, with Axn^S044230

lethal | maternal effect, with Axn^{ΔArm.αTub84B.Tag:FLAG}

Axn^S044230

lethal | maternal effect, with Axn^{ΔI.αTub84B.Tag:FLAG}

Axn^S044230

lethal | maternal effect, with Axn^{ΔRGS.αTub84B.Tag:FLAG}

Axn^S044230

lethal | recessive

Axn^S044230

lethal - all die before end of larval stage | recessive

Axn^S044230

lethal - all die before end of P-stage, with Axn^{L501P.αTub84B.Tag:FLAG}, Axn^S044230

Axn^{ΔRGS.αTub84B.Tag:FLAG}

lethal - all die before end of P-stage, with Axn^{ΔRGS.αTub84B.Tag:FLAG}, Axn^{L501P.αTub84B.Tag:FLAG}

Axn^S044230

lethal - all die before end of P-stage, with Axn^{ΔRGS.αTub84B.Tag:FLAG}, Axn^S044230

Axn^{L501P.αTub84B.Tag:FLAG}

lethal - all die before end of pupal stage

Axn¹²⁷

lethal - all die during embryonic stage, with Scer\GAL4^arm.PS

Axn^{EDDNmut.UAS.GFP}

lethal - all die during embryonic stage, with Scer\GAL4^ptc-559.1

Axn^UAS.GFP

lethal - all die during embryonic stage | maternal effect

Axn^S044230

lethal - all die during embryonic stage | maternal effect, with Axn^{L447Q.αTub84B.Tag:FLAG}

Axn^S044230

lethal - all die during embryonic stage | maternal effect, with Axn^S044230

lethal - all die during embryonic stage | maternal effect, with Axn^{ΔDIX.αTub84B.Tag:FLAG}

Axn^S044230

lethal - all die during embryonic stage | maternal effect, with Axn^{ΔPP2A.DIX.αTub84B.Tag:FLAG}

Axn^S044230

lethal - all die during embryonic stage | maternal effect, with Axn^{ΔPP2A.αTub84B.Tag:FLAG}

Axn^S044230

lethal - all die during embryonic stage | maternal effect, with Axn^{ΔRGS.Arm.αTub84B.Tag:FLAG}

Axn^S044230

lethal - all die during embryonic stage | maternal effect, with Axn^{ΔSgg.αTub84B.Tag:FLAG}

Axn^S044230

partially lethal - majority die

Axn^{L447Q.αTub84B.Tag:FLAG}

partially lethal - majority live

partially lethal - majority live | maternal effect

Axn^{αTub84B.Tag:FLAG}

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Axn^GD1334

viable, with Scer\GAL4^arm.PS

Axn^{FGmut.UAS.GFP}

viable, with Scer\GAL4^Mef2.PR

Axn^GD1334

viable, with Scer\GAL4^pnr-MD237

Axn^GD1334

viable, with Scer\GAL4^tin.CΔ4

Axn^GD1334

Other Phenotypes

Allele

abnormal cell shape | oogenesis | oogenesis | somatic clone

Axn^S044230

abnormal cell shape | somatic clone | third instar larval stage

Axn^S044230

abnormal mitotic cell cycle | somatic clone

Axn^h

abnormal neuroanatomy, with Scer\GAL4^{neur-GAL4-A101}

Axn^UAS.cHa

abnormal size | larval stage | somatic clone | heat sensitive

abnormal starvation stress response

Axn¹²⁷

abnormal starvation stress response | somatic clone

Axn¹²⁷

increased cell death | somatic clone | nutrition conditional

Axn¹²⁷

increased cell number | oogenesis | somatic clone

increased occurrence of cell division | cell autonomous | somatic clone

Axn^S044230

increased occurrence of cell division | larval stage | somatic clone

Axn^h

majority die during embryonic stage | maternal effect

majority die during embryonic stage | maternal effect, with Axn^{L447S.αTub84B.Tag:FLAG}

Axn^S044230

majority die during embryonic stage | maternal effect, with Axn^S044230

Axn^{L447S.αTub84B.Tag:FLAG}

neoplasia | larval stage | somatic clone

neoplasia | larval stage | somatic clone | heat sensitive

Axn^V72R.KI

some die during embryonic stage, with Scer\GAL4^arm.PS

Axn^{EDDNmut.UAS.GFP}

some die during embryonic stage, with Scer\GAL4^ptc-559.1

Axn^UAS.GFP

some die during embryonic stage | maternal effect

some die during embryonic stage | maternal effect, with Axn^{H504L.αTub84B.Tag:FLAG}

Axn^S044230

some die during embryonic stage | maternal effect, with Axn^{K446E.αTub84B.Tag:FLAG}

Axn^S044230

some die during embryonic stage | maternal effect, with Axn^{L501P.αTub84B.Tag:FLAG}

Axn^S044230

some die during embryonic stage | maternal effect, with Axn^S044230

some die during larval stage | recessive

Axn^S044230

visible

Axn^{L447Q.αTub84B.Tag:FLAG}

visible, with Scer\GAL4^71B

Axn^UAS.cHa

visible, with Scer\GAL4^bbg-C96

Axn^UAS.GFP

visible, with Scer\GAL4^pnr-MD237

Axn^GD1334

visible, with Scer\GAL4^salm.E

Axn^UAS.cSa

visible, with Scer\GAL4^tsh-Gal4-1

Axn^UAS.cHa

visible | adult stage

Axn^Tag:V5

visible | adult stage, with Scer\GAL4^C-765

visible | somatic clone

wild-type

Phenotype manifest in

Allele

abdominal sternite bristle

Axn^Tag:V5

abdominal sternite bristle, with Scer\GAL4^tsh-Gal4-1

Axn^UAS.cHa

adult abdomen, with Scer\GAL4^tsh-Gal4-1

Axn^UAS.cHa

adult abdomen & macrochaeta | somatic clone

Axn^S044230

adult abdomen | somatic clone

Axn^S044230

adult cuticle | ectopic | somatic clone

Axn^h

adult heart, with Scer\GAL4^tin.CΔ4

Axn^UAS.GFP

basal stalk | somatic clone

denticle, with Scer\GAL4^da.G32

denticle | ectopic, with Scer\GAL4^e22c

Axn^UAS.GFP

denticle | increased number, with Axn^S044230, Scer\GAL4^da.G32

Axn^UAS.cHa

denticle | increased number, with Axn^UAS.cHa, Scer\GAL4^da.G32

Axn^S044230

denticle belt

Axn^S044230

denticle belt, with Axn^S044230, Scer\GAL4^da.G32

denticle belt, with Axn^UAS.cHa, Scer\GAL4^da.G32

Axn^S044230

denticle belt, with Axn^{UAS.Tag:Myr(Src64B),Tag:FLAG}, Scer\GAL4^da.G32

Axn^S044230

denticle belt, with Scer\GAL4^da.G32

Axn^{UAS.Tag:Myr(Src64B),Tag:FLAG}

denticle belt | germline clone

Axn^S044230

denticle belt | maternal effect

denticle belt | maternal effect, with Axn^{L447Q.αTub84B.Tag:FLAG}

Axn^S044230

denticle belt | maternal effect, with Axn^{L447S.αTub84B.Tag:FLAG}

Axn^S044230

denticle belt | maternal effect, with Axn^S044230

denticle belt | maternal effect, with Axn^{ΔArm.αTub84B.Tag:FLAG}

Axn^S044230

denticle belt | maternal effect, with Axn^{ΔRGS.Arm.αTub84B.Tag:FLAG}

Axn^S044230

denticle belt | maternal effect, with Axn^{ΔSgg.αTub84B.Tag:FLAG}

Axn^S044230

denticle row 1 | maternal effect, with Axn^S044230

denticle row 1 | maternal effect, with Axn^{ΔArm.αTub84B.Tag:FLAG}

Axn^S044230

denticle row 1 | maternal effect, with Axn^{ΔRGS.αTub84B.Tag:FLAG}

Axn^S044230

denticle row 1 | maternal effect, with Axn^{ΔRGS.αTub84B.Tag:FLAG}/Axn^{ΔArm.αTub84B.Tag:FLAG}

Axn^S044230

denticle row 1 | maternal effect (with Axn^{ΔArm.αTub84B.Tag:FLAG}), with Axn^S044230

Axn^{ΔRGS.αTub84B.Tag:FLAG}

denticle row 1 | maternal effect (with Axn^{ΔRGS.αTub84B.Tag:FLAG}), with Axn^S044230

Axn^{ΔArm.αTub84B.Tag:FLAG}

denticle row | ectopic | maternal effect, with Axn^S044230

denticle row | ectopic | maternal effect, with Axn^{ΔDIX.αTub84B.Tag:FLAG}

Axn^S044230

denticle row | ectopic | maternal effect, with Axn^{ΔPP2A.αTub84B.Tag:FLAG}

Axn^S044230

dorsal medial indirect flight muscle, with Scer\GAL4¹¹⁵¹

Axn^UAS.GFP

dorsal medial indirect flight muscle, with Scer\GAL4^ebd1.PB

Axn^UAS.GFP

embryonic/first instar larval cuticle

embryonic/first instar larval cuticle, with Scer\GAL4^arm.PS

Axn^UAS.GFP

embryonic/first instar larval cuticle, with Scer\GAL4^e22c

Axn^UAS.GFP

embryonic/first instar larval cuticle | maternal effect

Axn^{ΔPP2A.αTub84B.Tag:FLAG}

embryonic/first instar larval cuticle | maternal effect, with Axn^S044230

embryonic/first instar larval cuticle | maternal effect, with Axn^{ΔDIX.αTub84B.Tag:FLAG}

Axn^S044230

embryonic/first instar larval cuticle | maternal effect, with Axn^{ΔPP2A.DIX.αTub84B.Tag:FLAG}

Axn^S044230

embryonic/first instar larval cuticle | maternal effect, with Axn^{ΔPP2A.αTub84B.Tag:FLAG}

Axn^S044230

embryonic/larval cuticle | embryonic stage, with Scer\GAL4^arm.PS

Axn^{EDDNmut.UAS.GFP}

embryonic/larval dorsal branch, with Scer\GAL4^btl.PS

Axn^UAS.cHa

embryonic/larval dorsal trunk, with Scer\GAL4^btl.PS

embryonic/larval lateral trunk, with Scer\GAL4^btl.PS

Axn^UAS.cHa

embryonic epidermis, with Scer\GAL4^da.G32

eye, with Scer\GAL4^GMR.PF

Axn^A1.UAS

eye | somatic clone

eye disc | somatic clone

eye disc | somatic clone | nutrition conditional

Axn¹²⁷

follicle cell | somatic clone

Axn^S044230

follicle stem cell | somatic clone

Axn^S044230

frons | ectopic | somatic clone

Axn^h

G1 phase | somatic clone

Axn^S044230

germline cyst | somatic clone

Axn^S044230

indirect flight muscle, with Scer\GAL4¹¹⁵¹

Axn^UAS.GFP

indirect flight muscle, with Scer\GAL4^ebd1.PB

Axn^UAS.GFP

intestinal stem cell | somatic clone

Axn^S044230

leg, with Scer\GAL4^tsh-Gal4-1

Axn^UAS.cHa

leg | ectopic

Axn^S044230

leg | somatic clone

Axn^S044230

macrochaeta | ectopic | somatic clone

Axn^S044230

mesothoracic tergum, with Scer\GAL4^pnr-MD237

Axn^GD1334

mesothoracic tergum | ectopic, with Scer\GAL4^sd-SG29.1

Axn^A2.UAS

mesothoracic tergum primordium | larval stage | somatic clone

Axn^V72R.KI

mitotic cell cycle | somatic clone

Axn^h

morphogenetic furrow | somatic clone

Axn^E77

multidendritic neuron, with Scer\GAL4^{neur-GAL4-A101}

Axn^UAS.cHa

ovary | somatic clone, with Scer\GAL4^Act5C.PP

Axn^A2.UAS

photoreceptor cell | somatic clone

Axn^unspecified

polar follicle cell | somatic clone

Axn¹⁵¹¹

polar follicle cell | somatic clone | increased number

Axn^S044230

stalk follicle cell | somatic clone

Axn¹⁵¹¹

stalk follicle cell | somatic clone | increased number

Axn^S044230

sternite

Axn^{L447Q.αTub84B.Tag:FLAG}

sternite, with Scer\GAL4^tsh-Gal4-1

Axn^UAS.cHa

tracheal fusion cell, with Scer\GAL4^btl.PS

Axn^UAS.GFP

tracheal tip cell | embryonic stage | increased number, with Scer\GAL4^btl.PS

Axn^UAS.cHa

trichome of the posterior wing margin, with Scer\GAL4^sd-SG29.1

Axn^A2.UAS

ventral thoracic disc, with Scer\GAL4^Dll-md23

Axn^UAS.cHa

wing, with Scer\GAL4^69B

wing, with Scer\GAL4^71B

Axn^UAS.cHa

wing, with Scer\GAL4^ap-md544

Axn^A2.UAS

wing, with Scer\GAL4^sd-SG29.1

Axn^A2.UAS

wing & chaeta | ectopic | somatic clone

Axn^unspecified

wing | somatic clone

wing | somatic clone, with Scer\GAL4^vg.int2.1

Axn^{EDDNmut.UAS.GFP}

wing blade, with Scer\GAL4^C-765

wing disc | somatic clone

wing disc | somatic clone | heat sensitive

wing disc | somatic clone | third instar larval stage

Axn^S044230

wing hinge primordium | larval stage | somatic clone

Axn^V72R.KI

wing margin, with Scer\GAL4^bbg-C96

Axn^UAS.GFP

wing margin, with Scer\GAL4^C-765

wing margin, with Scer\GAL4^salm.E

Axn^UAS.cSa

wing margin, with Scer\GAL4^sd-SG29.1

Axn^A2.UAS

wing margin, with Scer\GAL4^vg.int2.1

Axn^{FGmut.UAS.GFP}

wing margin bristle, with Scer\GAL4^C-765

wing margin bristle | cell autonomous | ectopic | somatic clone

Axn^S044230

wing margin bristle | ectopic | somatic clone

Axn^S044230

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (23)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\AXIN1

12 of 15

Yes

Hsap\AXIN2

10 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (22)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Axin1

12 of 15

Yes

Mmus\Axin2

10 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Rattus norvegicus (Norway rat) (19)

Rnor\Axin2

6 of 13

Yes

Rnor\Axin1

5 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Xenopus tropicalis (Western clawed frog) (16)

Xtro\axin1

11 of 12

Yes

Xtro\axin2

6 of 12

Yes

Xtro\cep112

6 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Danio rerio (Zebrafish) (25)

Drer\axin1

11 of 15

Yes

Drer\axin2

11 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Drer\si:ch211-117l17.5

1 of 15

Drer\si:ch211-117l17.6

1 of 15

Drer\si:ch211-196h16.12

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (13)

Cele\pry-1

3 of 15

Yes

Cele\rgs-8.1

2 of 15

Yes

Cele\rgs-9

2 of 15

Yes

Cele\rgs-10

2 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (2)

Scer\RGS2

1 of 15

Yes

Scer\SST2

1 of 15

Yes

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190493 )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA20694

Drosophila persimilis

Dper\GL14019

Drosophila willistoni

Dwil\GK13864

Drosophila virilis

Dvir\GJ10774

Drosophila mojavensis

Dmoj\GI24204

Drosophila grimshawi

Dgri\GH19169

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091502UI )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17012870

Glossina morsitans

Tsetse fly

Gmor\GMOY010531

Mayetiola destructor

Hessian fly

Mdes\Mdes007114

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL003388

Anopheles darlingi

American malaria mosquito

Adar\ADAC007393

Anopheles gambiae

Malaria mosquito

Agam\AGAP002123

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ001221

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W06UP )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA007134

Bombyx mori

Silkmoth

Bmor\BGIBMGA007135

Danaus plexippus

Monarch butterfly

Dple\DPOGS210820-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL008519

Apis florea

Little honeybee

Aflo\2416052004

Apis mellifera

Western honey bee

Amel\GB47277

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP17164

Bombus terrestris

Buff-tailed bumblebee

Bter\15212487

Linepithema humile

Argentine ant

Lhum\LH20655

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:000f63

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG008398

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_07501

Tribolium castaneum

Red flour beetle

Tcas\Axn

Pediculus humanus

Human body louse

Phum\PHUM327400

Rhodnius prolixus

Kissing bug

Rpro\RPRC013448

Cimex lectularius

Bed bug

Clec\CLEC010968

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI008356

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_01674

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X06PZ )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR013467

Ixodes scapularis

Black-legged tick

Isca\ISCW013850

Stegodyphus mimosarum

African social velvet spider

Smim\KFM57390.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM78439.1

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_301655

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0ABG )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Axin

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000002620

Gallus gallus

Domestic chicken

Ggal\AXIN2

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000027391

Gallus gallus

Domestic chicken

Ggal\AXIN1

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000025994

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (4)

Gene Symbol

Score

Source

Alignment

1 of 10

1 of 10

1 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

cancer, multiple, AXIN-related

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 3 )

Allele

Disease

Evidence

References

Axn^{FGmut.UAS.GFP}

model of cancer

CEA

(Mendoza-Topaz et al., 2011)

Axn^L67P.KI

model of cancer

CEA

(Anvarian et al., 2016)

Axn^V72R.KI

model of cancer

CEA

(Anvarian et al., 2016)

Potential Models Based on Orthology ( 2 )

Human Ortholog

Disease

Evidence

References

AXIN1; axin 1

model of hepatocellular carcinoma

IEA

(FlyBase, 2019-)

AXIN2; axin 2

model of colorectal cancer

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 4 )

Allele

Disease

Interaction

References

Axn^GD1334

exacerbates cancer

modeled by Dl^UAS.cDa, lola^GS88A8, psq^GS88A8

(Even et al., 2019)

Axn^UAS.GFP

DOES NOT ameliorate cancer

modeled by Hipk^UAS.Tag:HA

(Blaquiere et al., 2018)

ameliorates familial adenomatous polyposis 1

modeled by Apc2^N175K, Apc^Q8

(Mendoza-Topaz et al., 2011)

Axn^{FGmut.UAS.GFP}

model of cancer

is exacerbated by dsh³

(Mendoza-Topaz et al., 2011)

Axn^UAS.cUa

ameliorates Huntington's disease

modeled by Hsap\HTT^Q93.ex1.UAS

(Dupont et al., 2012)

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

AXIN1; axin 1

12 of 15

603816

hepatocellular carcinoma

AXIN2; axin 2

10 of 15

604025

colorectal cancer

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Axn - Apc2

bimolecular fluorescence complementation, fluorescence microscopy, anti tag coimmunoprecipitation, anti tag western blot, two hybrid, western blot

(Lybrand et al., 2019, Tacchelly-Benites et al., 2018, Croy et al., 2016, Wang et al., 2016, Kunttas-Tatli et al., 2015, Pronobis et al., 2015, Peradziryi et al., 2011, Roberts et al., 2011)

Axn - CAP

pull down, western blot, two hybrid

(Yamazaki and Yanagawa, 2003, Yamazaki and Nusse, 2002)

Axn - Gαo

pull down, molecular weight estimation by staining

(Egger-Adam and Katanaev, 2010)

Axn - Klp64D

anti bait coimmunoprecipitation, western blot

(Vuong et al., 2018)

Axn - Oseg1

anti tag coimmunoprecipitation, western blot

(Vuong et al., 2018)

Axn - Tnks

anti tag coimmunoprecipitation, anti tag western blot

(Feng et al., 2014)

Axn - arm

two hybrid

(Kremer et al., 2010, Tolwinski et al., 2003)

Axn - arr

two hybrid, pull down, western blot, anti tag coimmunoprecipitation

(Tacchelly-Benites et al., 2018, Tolwinski et al., 2003, Yamazaki and Yanagawa, 2003)

Axn - dsh

pull down, autoradiography, western blot

(Capilla et al., 2012, Yamazaki and Yanagawa, 2003)

Axn - rempA

pull down, western blot, anti tag coimmunoprecipitation

(Vuong et al., 2018)

Axn - sgg

anti tag coimmunoprecipitation, peptide massfingerprinting, bimolecular fluorescence complementation, fluorescence microscopy, two hybrid

(Lybrand et al., 2019, Neumüller et al., 2012, Kremer et al., 2010)

RNA-RNA

Physical Interaction

Assay

References

Axn - mir-315

luminiscence technology, necessary binding region, fluorescence technology

(Silver et al., 2007)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Axn

suppressible

arm

(Caviglia and Luschnig, 2013)

enhanceable

(Dai et al., 2017)

suppressible

(Cliffe et al., 2003)

Axn|Rbf

suppressible

hid

(Zhang et al., 2014)

enhanceable

(Lee et al., 2009)

enhanceable

(Zhang et al., 2014)

Rbf|Axn

enhanceable

Lkb1

(Zhang et al., 2014)

Axn

enhanceable

(Dai et al., 2017)

Axn

suppressible

nmo

(Zeng and Verheyen, 2004)

Axn

suppressible

pan

(Lee et al., 2009, Lee and Treisman, 2001)

Axn

suppressible

pygo

(Parker et al., 2002)

Axn|Rbf

suppressible

raptor

(Zhang et al., 2014)

Axn

enhanceable

Rbf

(Zhang et al., 2014)

Axn|Rbf

suppressible

Rheb

(Zhang et al., 2014)

Axn

suppressible

salm

(Caviglia and Luschnig, 2013)

Axn

suppressible

Tnks

(Feng et al., 2014)

Axn

enhanceable

Tnks

(Feng et al., 2014)

Axn

suppressible

tum

(Jones and Bejsovec, 2005)

Axn

suppressible

(Cliffe et al., 2003)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

aop

suppressible

Axn

(Olson et al., 2011)

Apc2|Apc

suppressible

Axn

(Mendoza-Topaz et al., 2011, Tolwinski, 2009, Cliffe et al., 2003)

arm

suppressible

Axn

(Tolwinski and Wieschaus, 2001)

brat

enhanceable

Axn

(Komori et al., 2014)

enhanceable

(Dai et al., 2017)

suppressible

(Mitchell et al., 2008)

CycE

enhanceable

Axn

(Brumby et al., 2004)

enhanceable

Axn

(Even et al., 2019)

Dl|lola|psq

enhanceable

Axn

(Even et al., 2019)

dsh

suppressible

Axn

(Penton et al., 2002)

gskt

suppressible

Axn

(Kalamegham et al., 2007)

hep

suppressible

Axn

(Zhang et al., 2015)

Hipk

suppressible

Axn

(Blaquiere et al., 2018)

mir-315

suppressible

Axn

(Silver et al., 2007)

nmo

enhanceable

Axn

(Zeng and Verheyen, 2004)

Rbf

enhanceable

Axn

(Zhang et al., 2014)

Rnf146

suppressible

Axn

(Gultekin and Steller, 2019)

sgg

suppressible

Axn

(Tolwinski, 2009, Collins and Treisman, 2000)

Tnks

suppressible

Axn

(Wang et al., 2016)

tsh

suppressible

Axn

(Bessa and Casares, 2005)

suppressible

Axn

(Tolwinski et al., 2003)

Wnt2

suppressible

Axn

(Willert et al., 1999)

External Data

Subunit Structure (UniProtKB)

Interacts with ZW3 and ARM. The interaction between AXN and ARM occurs via the armadillo repeats contained in ARM.

(UniProt, Q9V407 )

Linkouts

BioGRID - A database of protein and genetic interactions.

68421

DroID - A comprehensive database of gene and protein interactions.

FBgn0026597

MIST (genetic) - An integrated Molecular Interaction Database

MIST (protein-protein) - An integrated Molecular Interaction Database

Pathways

Signaling Pathways (FlyBase)

Negative Regulators of Wnt-TCF Signaling Pathway -: Negative regulators of Wnt-TCF (canonical Wnt) signaling down-regulate the pathway, resulting in the attenuation of transcriptional regulation mediated by β-catenin (arm).

Metabolic Pathways

External Data

Linkouts

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Wnt signaling pathway

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-100

Cytogenetic map

99D2-99D3

Sequence location

3R:30,022,842..30,035,311 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

99D2-99D3

Limits computationally determined from genome sequence between P{PZ}ncd⁰⁵⁸⁸⁴ and P{lacW}l(3)s2500^s2500

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

99D-99D

(Hamada, 1998.8.25)

99D3-99D9

(determined by in situ hybridisation)

(Szeged Stock Center, 1998-, Deak et al., 1997)

99D-99D

(determined by in situ hybridisation)

(Hamada et al., 1999, Willert et al., 1999)

Experimentally Determined Recombination Data

Location

3-100

(FlyBase, 2016)

3-97.4

(Comeron et al., 2012)

Left of (cM)

(Penton et al., 2002)

Right of (cM)

Notes

Stocks and Reagents

Stocks (12)

Bloomington

85627

w¹¹¹⁸; PBac{WH}Axn^f01654

31705

y¹ v¹; P{TRiP.HM04012}attP2

7225

w^*; Kr^If-1/CyO; P{UAS-Axn.GFP}3

9520

w¹¹⁸; P{UAS-dsh.myc}3-8 Axn^8-66

62434

y¹ v¹; P{TRiP.HMJ23888}attP40/CyO

7224

w^*; P{UAS-Axn.GFP}2/CyO; Ki¹/TM3, Sb¹

9523

w¹¹⁸; P{UAS-dsh.myc}1-16 Axn^16-21/TM6B, Tb¹

80521

y¹ sc^* v¹ sev²¹; P{TOE.GS02478}attP40

17649

y¹ w^67c23; P{EPgy2}Axn^EY10228/TM3, Sb¹ Ser¹

VDRC

v330421

P{VSH330421}attP40

v7748

w¹¹¹⁸; P{GD1334}v7748/TM3

v318788

PBac{fTRG01182.sfGFP-TVPTBF}VK00002

Genomic Clones (18)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (46)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

FI19317

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0026597

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0026597

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

43565

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Wang et al., 2016, Yang et al., 2016, Peradziryi et al., 2011, Yamazaki and Nusse, 2002, Willert et al., 1999)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for database merge of

Additional comments

Other Comments

dsRNA made from templates generated with primers directed against this gene.

(Mosimann et al., 2006)

dsRNA has been made from templates generated with primers directed against this gene.

(Rives et al., 2006)

S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.

(Stroschein-Stevenson et al., 2006)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Mutations in Axn prevent photoreceptor differentiation and lead to tissue overgrowth in the eye disc, due to ectopic activation of the wg pathway.

(Lee and Treisman, 2001)

Axn negatively regulates wg signaling by downregulating the level of arm.

(Hamada et al., 1999)

Axn inhibits Wnt signalling.

(Willert et al., 1999)

Axn loss of function phenotypes are similar to wg overexpression phenotypes. Axn overexpression phenotypes are similar to wg loss of function phenotypes.

(Willert et al., 1999)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 90 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

43565

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9V407

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0026597

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0026597

DRscDB

43565/tissue=All

EMBL-EBI Single Cell Expression Atlas

FBgn0026597

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Axn_1
Axn_2

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG7926

Flygut - An atlas of the Drosophila adult midgut

FBgn0026597

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

85721

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

43565

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC006314

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG7926

MARRVEL_MODEL

43565

modMine - A data warehouse for the modENCODE project

FBgn0026597

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q9V407

Linkouts

BioGRID - A database of protein and genetic interactions.

68421

DroID - A comprehensive database of gene and protein interactions.

FBgn0026597

DRSC - Results frm RNAi screens

FBgn0026597

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG7926-RA

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0026597

FlyMine - An integrated database for Drosophila genomics

FBgn0026597

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Wnt signaling pathway

MIST (genetic) - An integrated Molecular Interaction Database

MIST (protein-protein) - An integrated Molecular Interaction Database

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synonyms and Secondary IDs (21)

Reported As

Symbol Synonym

0442/30

(Deak et al., 1997)

APC

(Chen and Jiang, 2013, Casad et al., 2012)

CG7926

(Meadows, 2017.9.14, Fukuoh et al., 2014, Awofala et al., 2012, Perkins et al., 2009, Ni et al., 2008)

D-Axin

(Siegfried and Steitz, 2000, Hamada et al., 1999)

DAxin

(Cong and Varmus, 2004, Rulifson et al., 2000)

Daxin

(Merino et al., 2015, Merino et al., 2013, Hendriksen et al., 2005, Baeg et al., 2004, Zeng and Verheyen, 2004, Yamazaki and Yanagawa, 2003, Rives et al., 2002, Chihara and Hayashi, 2000, Yamazaki et al., 2000, Yanagawa et al., 2000, Willert et al., 1999)

GSK3β

(Zhang et al., 2021, Prüßing et al., 2013, Casad et al., 2012)

axn

(Baker, 2020, Melamed and Kalderon, 2020, Vuong et al., 2018, Moulton and Letsou, 2016, Matsuda et al., 2015, Zhang et al., 2014, Awofala et al., 2012, Smibert et al., 2012, DasGupta et al., 2007, Stroschein-Stevenson et al., 2006, DasGupta et al., 2005, Brumby et al., 2004, Bartoszewski and Großhans, 2003, Baonza and Freeman, 2002, Tolwinski and Wieschaus, 2001)

d-axin

(Tomoyasu et al., 2000, Hamada et al., 1999, Hamada, 1998.8.25)

dAXIN

(Li et al., 2002)

dAxin

(Magri et al., 2018, Gonsalves et al., 2011, Luo et al., 2007, Srahna et al., 2006, Parker et al., 2002, Zheng et al., 1999)

din

(Colton et al., 1999)

l(3)S044230

(Hamada et al., 1999)

Name Synonyms

Axin

(Cui et al., 2020, Newell et al., 2020, Even et al., 2019, Lybrand et al., 2019, Wang et al., 2019, Xu et al., 2019, Anvarian et al., 2016, Croy et al., 2016, Deshpande et al., 2016, Wang et al., 2016, Balmer et al., 2015, Matsuda et al., 2015, Jenny and Basler, 2014, Komori et al., 2014, Kunttas-Tatli et al., 2014, Zhang et al., 2014, Caviglia and Luschnig, 2013, Mbodj et al., 2013, Pancratov et al., 2013, Awofala et al., 2012, Capilla et al., 2012, Benchabane et al., 2011, Karim and Moore, 2011, Muñoz-Descalzo et al., 2011, Peradziryi et al., 2011, Roberts et al., 2011, Egger-Adam and Katanaev, 2010, Jones et al., 2010, Kremer et al., 2010, Metcalfe et al., 2010, Taniue et al., 2010, Song et al., 2009, Alexandre et al., 2008, Blauwkamp et al., 2008, Chang et al., 2008, Herranz et al., 2008, Mitchell et al., 2008, Peterson-Nedry et al., 2008, Rafel and Milán, 2008, Takacs et al., 2008, Takacs et al., 2008, Wehrli et al., 2008, Chan et al., 2007, Kalamegham et al., 2007, Silver et al., 2007, Wehrli et al., 2007, Zimmerman et al., 2007, Clevers, 2006, Hayward et al., 2006, Heeg-Truesdell, 2006, Rives et al., 2006, Furlong, 2005, Marques, 2005, Xie et al., 2005, Bilder, 2001, Nusse, 2001, Behrens, 2000, Peifer and Polakis, 2000, Colton et al., 1999)

Axn

(Abdou et al., 2011)

D-axin

(Wharton et al., 2000)

Daxin

(Feng et al., 2014, Zhang et al., 2011, Lee et al., 2009, Matsubayashi et al., 2004)

Dm Axin

(Konikoff et al., 2010)

axin

(Baker, 2017, Grifoni and Bellosta, 2015, Dupont et al., 2012, Olson et al., 2011, Zhang et al., 2011, Kremer et al., 2010, Zimmerman et al., 2010, Piddini and Vincent, 2009, Tolwinski, 2009, Estella and Mann, 2008, Peterson-Nedry et al., 2008, Thompson et al., 2008, Baig-Lewis et al., 2007, Silver et al., 2007, Tyler and Baker, 2007, Stadeli, 2006, DasGupta et al., 2005)

axn

(Cliffe et al., 2004)

d-Axin

(Kalamegham et al., 2007)

dAxin

(Anvarian et al., 2016, Quijano et al., 2011, Quijano et al., 2010, Kalamegham et al., 2007)

daxin

(Colton et al., 1999)

glycogen synthase kinase 3β

(Prüßing et al., 2013)

Secondary FlyBase IDs

FBgn0028152

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