• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • RNA-Seq Search
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • GBrowse 2 Beta
    • CytoSearch
    • Feature Mapper
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Current release
  • Archived releases
  • Map Conversion
  • FTP site:
  • Releases (FTP)
  • Genomes (FTP)
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Vectors & Constructs
  • Other links:
  • BDGP
  • DGRC
  • DIS by issue
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\Axn

General Information
Symbol	Dmel\Axn	Species	D. melanogaster
Name	Axin	Annotation symbol	CG7926
Feature type	protein_coding_gene	FlyBase ID	FBgn0026597
Gene Model Status	Current	Stock availability	8 publicly available
Also Known As	axin, dAxin, d-axin
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	99D2-99D3	Sequence location	3R:25,848,564..25,861,033 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Axin is referred to in FlyBase by the symbol Dmel\Axn (CG7926, FBgn0026597). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: beta-catenin binding; protein kinase binding. There is experimental evidence that it is involved in the biological process: imaginal disc pattern formation; heart development; eye-antennal disc morphogenesis; somatic stem cell maintenance; negative regulation of Wnt receptor signaling pathway; oogenesis; imaginal disc-derived wing morphogenesis; Wnt receptor signaling pathway; phagocytosis, engulfment. 43 alleles are reported. The phenotypes of these alleles are annotated with: organ system; organ system subdivision; adult segment; portion of tissue; thoracic segment; adult; indirect flight muscle; tracheal system; acellular anatomical structure; external compound sense organ. It has 7 annotated transcripts and 7 annotated polypeptides. Protein features are: Axin beta-catenin binding; DIX domain; Regulator of G protein signalling; Regulator of G protein signalling superfamily; Regulator of G-protein signaling, domain 1. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, larval hindgut, larval trachea, adult ovary, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1632134_s_at completely aligns to an exonic region common to each of the 5 FlyBase-annotated transcript isoforms of Axn. Gene sequence location is 3R:25848564..25861033.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02	Controlled Vocabulary Terms GTPase activator activity
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 99D2-99D3   Limits computationally determined from genome sequence between P{PZ}ncd05884 and P{lacW}l(3)s2500s2500
Experimentally Determined Cytological Location
Cytogenetic map Notes References 99D-99D     (Hamada, 1998.8.25) 99D-99D   (determined by in situ hybridisation)   (Willert et al., 1999) 99D3-99D9   (determined by in situ hybridisation)   (Szeged Stock Center, 1998-) 99D-99D   (determined by in situ hybridisation)   (Hamada et al., 1999) 99D3-99D9   (determined by in situ hybridisation)   (Deak et al., 1997)
Experimentally Determined Recombination Data
Location
Left of (cM)	dco (Penton et al., 2002)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Axn for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.47 Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated Low-frequency RNA-Seq exon junction(s) not annotated. Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Axn-RA FBtr0085553  NM_170457   4691   745 Axn-RB FBtr0085555  NM_170458   3638   745 Axn-RC FBtr0085554  NM_170459   4281   739 Axn-RD FBtr0290030  NM_001144654   4553   699 Axn-RE FBtr0300600  NM_001170302   3578   110 Axn-RF FBtr0334702  NM_001276168   4535   693 Axn-RG FBtr0334703  NM_001276169   3620   739
Additional Transcript Data & Comments
Reported size (kB)	2.232 (longest cDNA) (Hamada et al., 1999)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Axn-PA   FBpp0084919   81.7   745   8.05     NP_733336   AAF56993 Axn-PB   FBpp0084921   81.7   745   8.05     NP_733337   AAN14207 Axn-PC   FBpp0084920   81.2   739   7.91     NP_733338   AAN14208 Axn-PD   FBpp0288469   76.9   699   8.22     NP_001138126   ACL83582 Axn-PE   FBpp0289827   12.5   110   6.10     NP_001163773   ACZ95067 Axn-PF   FBpp0306757   76.3   693   8.09     NP_001263097   AGB96476 Axn-PG   FBpp0306758   81.2   739   7.91     NP_001263098   AGB96477
Additional Polypeptide Data & Comments
Reported size (kDa)	743 (aa) (Hamada et al., 1999)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Regulator of G protein signalling (IPR000342) DIX domain (IPR001158) Regulator of G-protein signaling, domain 1 (IPR024066) Axin beta-catenin binding (IPR014936) Regulator of G protein signalling superfamily (IPR016137)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201808   AA246415   AA263825   AA390318   AA391937   AA392189   AA392528   AA392614   AA438976   AA441234   AA441255   AA539960   AA699261   AA951291   AE014297 AAF56993   AE014297 AAN14207   AE014297 AAN14208   AE014297 ACL83582   AE014297 ACZ95067   AF086811 AAD24886   AF091813 AAF21293   AE014297 AGB96476   AE014297 AGB96477   AI061696   AI114120   AI456021   AI456768   AI512229   AI513804   AI518781   AI518785   AI519142   AI519143   AI542455   AW943432   AY069619 AAL39764   BG633432   BG637850   BG638041   BI167942   BI169098   BI172530   BI172539   BI228474   BI241693   BI243408   BI357471   BI565517   BI579610   BI580891   BI585515   BI587775   BI588597   BI588915   BI607382   BI619505   BT011338   BT082102   BT133166   CL526196   CO176748   CO177154   CO178058   CO275705   CO276853   CO282743   CO303716   CO304687   CO306398   CO311605   CO314105   CO315486   CO317856   CO320630   CO323367   CZ484124   EC062126   EC063144   EC065371   EC068237   EC069603   EC076292   EC079065   EC083628   EC084282   EC089622   EC204347   EC204751   EC220565   EC222148   EC229619   EC230188   EC238373   EC248186   EC249037   EC249179   GH943463   GH945899   GH948571   GH960577   GH961532   GH962206   GH964686   GH979937   GH985106
UniProtKB/Swiss-Prot	Q9V407
UniProtKB/TrEMBL	Q8IMJ7 A4V3M5 B7Z0S0 E1JJ18 Q8T022
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Hamada et al., 1999)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
western blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage     (Willert et al., 1999)
Additional Descriptive Data
	Axn protein is detected in embryos from 0-1hr until 11-12hr. The lowest levels are seen at the earliest time points and increasing amounts are seen with developmental time. (Willert et al., 1999)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
cytoplasm inferred from direct assay (Cong and Varmus, 2004, Fiedler et al., 2011) nucleus inferred from direct assay (Cong and Varmus, 2004) plasma membrane inferred from direct assay (Fiedler et al., 2011)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, larval hindgut, larval trachea, adult ovary, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    383.625 Larval Midgut    77.1 Larval Hindgut    100 Larval Malpighian Tubules    74.3 Larval Fat Body    51.5 Larval Salivary Gland    95.6 Larval Trachea    144.9 Larval Carcass    108.525 Adult Head    78 Adult Eye    102.725 Adult Brain    249.5 Adult Thoracic-Abdominal Ganglion    173.1 Adult Crop    86.1 Adult Midgut    64.4 Adult Hindgut    58.9 Adult Malpighian Tubules    69.6 Adult Fat Body    65.3 Adult Salivary Gland    90.2 Adult Heart    60.075 Adult VirginFemale Spermatheca    77 Adult InseminatedFemale Spermatheca    72 Adult Ovary    308.2 Adult Testis    44.3 Adult Male Accessory Gland    95.2 Adult Carcass    54.4 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    383.625 Larval Midgut    77.1 Larval Hindgut    100 Larval Malpighian Tubules    74.3 Larval Fat Body    51.5 Larval Salivary Gland    95.6 Larval Trachea    144.9 Larval Carcass    108.525 Adult Head    78 Adult Eye    102.725 Adult Brain    249.5 Adult Thoracic-Abdominal Ganglion    173.1 Adult Crop    86.1 Adult Midgut    64.4 Adult Hindgut    58.9 Adult Malpighian Tubules    69.6 Adult Fat Body    65.3 Adult Salivary Gland    90.2 Adult Heart    60.075 Adult VirginFemale Spermatheca    77 Adult InseminatedFemale Spermatheca    72 Adult Ovary    308.2 Adult Testis    44.3 Adult Male Accessory Gland    95.2 Adult Carcass    54.4 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    383.625 Larval Midgut    77.1 Larval Hindgut    100 Larval Malpighian Tubules    74.3 Larval Fat Body    51.5 Larval Salivary Gland    95.6 Larval Trachea    144.9 Larval Carcass    108.525 Adult Head    78 Adult Eye    102.725 Adult Brain    249.5 Adult Thoracic-Abdominal Ganglion    173.1 Adult Crop    86.1 Adult Midgut    64.4 Adult Hindgut    58.9 Adult Malpighian Tubules    69.6 Adult Fat Body    65.3 Adult Salivary Gland    90.2 Adult Heart    60.075 Adult VirginFemale Spermatheca    77 Adult InseminatedFemale Spermatheca    72 Adult Ovary    308.2 Adult Testis    44.3 Adult Male Accessory Gland    95.2 Adult Carcass    54.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    383.625 Larval Midgut    77.1 Larval Hindgut    100 Larval Malpighian Tubules    74.3 Larval Fat Body    51.5 Larval Salivary Gland    95.6 Larval Trachea    144.9 Larval Carcass    108.525 Adult Head    78 Adult Eye    102.725 Adult Brain    249.5 Adult Thoracic-Abdominal Ganglion    173.1 Adult Crop    86.1 Adult Midgut    64.4 Adult Hindgut    58.9 Adult Malpighian Tubules    69.6 Adult Fat Body    65.3 Adult Salivary Gland    90.2 Adult Heart    60.075 Adult VirginFemale Spermatheca    77 Adult InseminatedFemale Spermatheca    72 Adult Ovary    308.2 Adult Testis    44.3 Adult Male Accessory Gland    95.2 Adult Carcass    54.4 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    383.625 Larval Midgut    77.1 Larval Hindgut    100 Larval Malpighian Tubules    74.3 Larval Fat Body    51.5 Larval Salivary Gland    95.6 Larval Trachea    144.9 Larval Carcass    108.525 Adult Head    78 Adult Eye    102.725 Adult Brain    249.5 Adult Thoracic-Abdominal Ganglion    173.1 Adult Crop    86.1 Adult Midgut    64.4 Adult Hindgut    58.9 Adult Malpighian Tubules    69.6 Adult Fat Body    65.3 Adult Salivary Gland    90.2 Adult Heart    60.075 Adult VirginFemale Spermatheca    77 Adult InseminatedFemale Spermatheca    72 Adult Ovary    308.2 Adult Testis    44.3 Adult Male Accessory Gland    95.2 Adult Carcass    54.4 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    383.625 Larval Midgut    77.1 Larval Hindgut    100 Larval Malpighian Tubules    74.3 Larval Fat Body    51.5 Larval Salivary Gland    95.6 Larval Trachea    144.9 Larval Carcass    108.525 Adult Head    78 Adult Eye    102.725 Adult Brain    249.5 Adult Thoracic-Abdominal Ganglion    173.1 Adult Crop    86.1 Adult Midgut    64.4 Adult Hindgut    58.9 Adult Malpighian Tubules    69.6 Adult Fat Body    65.3 Adult Salivary Gland    90.2 Adult Heart    60.075 Adult VirginFemale Spermatheca    77 Adult InseminatedFemale Spermatheca    72 Adult Ovary    308.2 Adult Testis    44.3 Adult Male Accessory Gland    95.2 Adult Carcass    54.4 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    383.625 Larval Midgut    77.1 Larval Hindgut    100 Larval Malpighian Tubules    74.3 Larval Fat Body    51.5 Larval Salivary Gland    95.6 Larval Trachea    144.9 Larval Carcass    108.525 Adult Head    78 Adult Eye    102.725 Adult Brain    249.5 Adult Thoracic-Abdominal Ganglion    173.1 Adult Crop    86.1 Adult Midgut    64.4 Adult Hindgut    58.9 Adult Malpighian Tubules    69.6 Adult Fat Body    65.3 Adult Salivary Gland    90.2 Adult Heart    60.075 Adult VirginFemale Spermatheca    77 Adult InseminatedFemale Spermatheca    72 Adult Ovary    308.2 Adult Testis    44.3 Adult Male Accessory Gland    95.2 Adult Carcass    54.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    383.625 Larval Midgut    77.1 Larval Hindgut    100 Larval Malpighian Tubules    74.3 Larval Fat Body    51.5 Larval Salivary Gland    95.6 Larval Trachea    144.9 Larval Carcass    108.525 Adult Head    78 Adult Eye    102.725 Adult Brain    249.5 Adult Thoracic-Abdominal Ganglion    173.1 Adult Crop    86.1 Adult Midgut    64.4 Adult Hindgut    58.9 Adult Malpighian Tubules    69.6 Adult Fat Body    65.3 Adult Salivary Gland    90.2 Adult Heart    60.075 Adult VirginFemale Spermatheca    77 Adult InseminatedFemale Spermatheca    72 Adult Ovary    308.2 Adult Testis    44.3 Adult Male Accessory Gland    95.2 Adult Carcass    54.4 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    78   NA  Eye    102.725   NA  Brain    249.5   383.625  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    173.1   NA  Crop    86.1   77.1  Midgut    64.4   100  Hindgut    58.9   74.3  Malpighian Tubules    69.6   51.5  Fat Body    65.3   95.6  Salivary Gland    90.2   NA  Heart    60.075   144.9  Trachea    NA   NA  VirginFemale Spermatheca    77   NA  InseminatedFemale Spermatheca    72   NA  Ovary    308.2   NA  Testis    44.3   NA  Male Accessory Gland    95.2   108.525  Carcass    54.4 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    34 central nervous system, larvae L3    37 central nervous system, pupae P8    18 head, virgin 1-day female    8 head, virgin 4-day female    10 head, virgin 20-day female    9 head, mated 1-day female    7 head, mated 4-day female    7 head, mated 20-day female    7 head, mated 1-day male    13 head, mated 4-day male    13 head, mated 20-day male    13 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    8 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    4 digestive system, 4-day adult    6 digestive system, 20-day adult    6 fat body, larvae L3 wandering    4 fat body, white prepupae    8 fat body, pupae P8    9 carcass, larvae L3 wandering    19 carcass, 1-day adult    5 carcass, 4-day adult    7 carcass, 20-day adult    7 ovary, virgin 4-day female    50 ovary, mated 4-day female    42 testis, mated 4-day male    6 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (34) central nervous system, larvae L3  (37) central nervous system, pupae P8    18 head, virgin 1-day female    8 head, virgin 4-day female    10 head, virgin 20-day female    9 head, mated 1-day female    7 head, mated 4-day female    7 head, mated 20-day female    7 head, mated 1-day male    13 head, mated 4-day male    13 head, mated 20-day male    13 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    8 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    4 digestive system, 4-day adult    6 digestive system, 20-day adult    6 fat body, larvae L3 wandering    4 fat body, white prepupae    8 fat body, pupae P8    9 carcass, larvae L3 wandering    19 carcass, 1-day adult    5 carcass, 4-day adult    7 carcass, 20-day adult    7 ovary, virgin 4-day female  (50) ovary, mated 4-day female  (42) testis, mated 4-day male    6 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    34 central nervous system, larvae L3    37 central nervous system, pupae P8    18 head, virgin 1-day female    8 head, virgin 4-day female    10 head, virgin 20-day female    9 head, mated 1-day female    7 head, mated 4-day female    7 head, mated 20-day female    7 head, mated 1-day male    13 head, mated 4-day male    13 head, mated 20-day male    13 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    8 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    4 digestive system, 4-day adult    6 digestive system, 20-day adult    6 fat body, larvae L3 wandering    4 fat body, white prepupae    8 fat body, pupae P8    9 carcass, larvae L3 wandering    19 carcass, 1-day adult    5 carcass, 4-day adult    7 carcass, 20-day adult    7 ovary, virgin 4-day female    50 ovary, mated 4-day female    42 testis, mated 4-day male    6 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    34 central nervous system, larvae L3    37 central nervous system, pupae P8    18 head, virgin 1-day female    8 head, virgin 4-day female    10 head, virgin 20-day female    9 head, mated 1-day female    7 head, mated 4-day female    7 head, mated 20-day female    7 head, mated 1-day male    13 head, mated 4-day male    13 head, mated 20-day male    13 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    8 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    4 digestive system, 4-day adult    6 digestive system, 20-day adult    6 fat body, larvae L3 wandering    4 fat body, white prepupae    8 fat body, pupae P8    9 carcass, larvae L3 wandering    19 carcass, 1-day adult    5 carcass, 4-day adult    7 carcass, 20-day adult    7 ovary, virgin 4-day female    50 ovary, mated 4-day female    42 testis, mated 4-day male    6 accessory gland, mated 4-day male    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    34 central nervous system, larvae L3    37 central nervous system, pupae P8    18 head, virgin 1-day female    8 head, virgin 4-day female    10 head, virgin 20-day female    9 head, mated 1-day female    7 head, mated 4-day female    7 head, mated 20-day female    7 head, mated 1-day male    13 head, mated 4-day male    13 head, mated 20-day male    13 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    8 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    4 digestive system, 4-day adult    6 digestive system, 20-day adult    6 fat body, larvae L3 wandering    4 fat body, white prepupae    8 fat body, pupae P8    9 carcass, larvae L3 wandering    19 carcass, 1-day adult    5 carcass, 4-day adult    7 carcass, 20-day adult    7 ovary, virgin 4-day female    50 ovary, mated 4-day female    42 testis, mated 4-day male    6 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (34) central nervous system, larvae L3  (37) central nervous system, pupae P8    18 head, virgin 1-day female    8 head, virgin 4-day female    10 head, virgin 20-day female    9 head, mated 1-day female    7 head, mated 4-day female    7 head, mated 20-day female    7 head, mated 1-day male    13 head, mated 4-day male    13 head, mated 20-day male    13 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    8 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    4 digestive system, 4-day adult    6 digestive system, 20-day adult    6 fat body, larvae L3 wandering    4 fat body, white prepupae    8 fat body, pupae P8    9 carcass, larvae L3 wandering    19 carcass, 1-day adult    5 carcass, 4-day adult    7 carcass, 20-day adult    7 ovary, virgin 4-day female  (50) ovary, mated 4-day female  (42) testis, mated 4-day male    6 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    34 central nervous system, larvae L3    37 central nervous system, pupae P8    18 head, virgin 1-day female    8 head, virgin 4-day female    10 head, virgin 20-day female    9 head, mated 1-day female    7 head, mated 4-day female    7 head, mated 20-day female    7 head, mated 1-day male    13 head, mated 4-day male    13 head, mated 20-day male    13 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    8 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    4 digestive system, 4-day adult    6 digestive system, 20-day adult    6 fat body, larvae L3 wandering    4 fat body, white prepupae    8 fat body, pupae P8    9 carcass, larvae L3 wandering    19 carcass, 1-day adult    5 carcass, 4-day adult    7 carcass, 20-day adult    7 ovary, virgin 4-day female    50 ovary, mated 4-day female    42 testis, mated 4-day male    6 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    34 central nervous system, larvae L3    37 central nervous system, pupae P8    18 head, virgin 1-day female    8 head, virgin 4-day female    10 head, virgin 20-day female    9 head, mated 1-day female    7 head, mated 4-day female    7 head, mated 20-day female    7 head, mated 1-day male    13 head, mated 4-day male    13 head, mated 20-day male    13 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    8 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    4 digestive system, 4-day adult    6 digestive system, 20-day adult    6 fat body, larvae L3 wandering    4 fat body, white prepupae    8 fat body, pupae P8    9 carcass, larvae L3 wandering    19 carcass, 1-day adult    5 carcass, 4-day adult    7 carcass, 20-day adult    7 ovary, virgin 4-day female    50 ovary, mated 4-day female    42 testis, mated 4-day male    6 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    46 embryo 02-04hr    67 embryo 04-06hr    46 embryo 06-08hr    46 embryo 08-10hr    41 embryo 10-12hr    27 embryo 12-14hr    27 embryo 14-16hr    23 embryo 16-18hr    19 embryo 18-20hr    13 embryo 20-22hr    22 embryo 22-24hr    21 larva L1    10 larva L2    8 larva L3 12hr old    6 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    18 white prepupae new    17 white prepupae 12hr    19 white prepupae 24hr    25 pupae 2d postWPP    17 pupae 3d postWPP    8 pupae 4d postWPP    7 adult male 01day    8 adult male 05day    9 adult male 30day    9 adult female 01day    16 adult female 05day    29 adult female 30day    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (46) embryo 02-04hr  (67) embryo 04-06hr  (46) embryo 06-08hr  (46) embryo 08-10hr  (41) embryo 10-12hr  (27) embryo 12-14hr  (27) embryo 14-16hr    23 embryo 16-18hr    19 embryo 18-20hr    13 embryo 20-22hr    22 embryo 22-24hr    21 larva L1    10 larva L2    8 larva L3 12hr old    6 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    18 white prepupae new    17 white prepupae 12hr    19 white prepupae 24hr    25 pupae 2d postWPP    17 pupae 3d postWPP    8 pupae 4d postWPP    7 adult male 01day    8 adult male 05day    9 adult male 30day    9 adult female 01day    16 adult female 05day  (29) adult female 30day  (29) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    46 embryo 02-04hr    67 embryo 04-06hr    46 embryo 06-08hr    46 embryo 08-10hr    41 embryo 10-12hr    27 embryo 12-14hr    27 embryo 14-16hr    23 embryo 16-18hr    19 embryo 18-20hr    13 embryo 20-22hr    22 embryo 22-24hr    21 larva L1    10 larva L2    8 larva L3 12hr old    6 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    18 white prepupae new    17 white prepupae 12hr    19 white prepupae 24hr    25 pupae 2d postWPP    17 pupae 3d postWPP    8 pupae 4d postWPP    7 adult male 01day    8 adult male 05day    9 adult male 30day    9 adult female 01day    16 adult female 05day    29 adult female 30day    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    46 embryo 02-04hr    67 embryo 04-06hr    46 embryo 06-08hr    46 embryo 08-10hr    41 embryo 10-12hr    27 embryo 12-14hr    27 embryo 14-16hr    23 embryo 16-18hr    19 embryo 18-20hr    13 embryo 20-22hr    22 embryo 22-24hr    21 larva L1    10 larva L2    8 larva L3 12hr old    6 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    18 white prepupae new    17 white prepupae 12hr    19 white prepupae 24hr    25 pupae 2d postWPP    17 pupae 3d postWPP    8 pupae 4d postWPP    7 adult male 01day    8 adult male 05day    9 adult male 30day    9 adult female 01day    16 adult female 05day    29 adult female 30day    29 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    46 embryo 02-04hr    67 embryo 04-06hr    46 embryo 06-08hr    46 embryo 08-10hr    41 embryo 10-12hr    27 embryo 12-14hr    27 embryo 14-16hr    23 embryo 16-18hr    19 embryo 18-20hr    13 embryo 20-22hr    22 embryo 22-24hr    21 larva L1    10 larva L2    8 larva L3 12hr old    6 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    18 white prepupae new    17 white prepupae 12hr    19 white prepupae 24hr    25 pupae 2d postWPP    17 pupae 3d postWPP    8 pupae 4d postWPP    7 adult male 01day    8 adult male 05day    9 adult male 30day    9 adult female 01day    16 adult female 05day    29 adult female 30day    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (46) embryo 02-04hr  (67) embryo 04-06hr  (46) embryo 06-08hr  (46) embryo 08-10hr  (41) embryo 10-12hr  27 embryo 12-14hr  27 embryo 14-16hr    23 embryo 16-18hr    19 embryo 18-20hr    13 embryo 20-22hr    22 embryo 22-24hr    21 larva L1    10 larva L2    8 larva L3 12hr old    6 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    18 white prepupae new    17 white prepupae 12hr    19 white prepupae 24hr    25 pupae 2d postWPP    17 pupae 3d postWPP    8 pupae 4d postWPP    7 adult male 01day    8 adult male 05day    9 adult male 30day    9 adult female 01day    16 adult female 05day  29 adult female 30day  29 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    46 embryo 02-04hr    67 embryo 04-06hr    46 embryo 06-08hr    46 embryo 08-10hr    41 embryo 10-12hr    27 embryo 12-14hr    27 embryo 14-16hr    23 embryo 16-18hr    19 embryo 18-20hr    13 embryo 20-22hr    22 embryo 22-24hr    21 larva L1    10 larva L2    8 larva L3 12hr old    6 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    18 white prepupae new    17 white prepupae 12hr    19 white prepupae 24hr    25 pupae 2d postWPP    17 pupae 3d postWPP    8 pupae 4d postWPP    7 adult male 01day    8 adult male 05day    9 adult male 30day    9 adult female 01day    16 adult female 05day    29 adult female 30day    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    46 embryo 02-04hr    67 embryo 04-06hr    46 embryo 06-08hr    46 embryo 08-10hr    41 embryo 10-12hr    27 embryo 12-14hr    27 embryo 14-16hr    23 embryo 16-18hr    19 embryo 18-20hr    13 embryo 20-22hr    22 embryo 22-24hr    21 larva L1    10 larva L2    8 larva L3 12hr old    6 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    18 white prepupae new    17 white prepupae 12hr    19 white prepupae 24hr    25 pupae 2d postWPP    17 pupae 3d postWPP    8 pupae 4d postWPP    7 adult male 01day    8 adult male 05day    9 adult male 30day    9 adult female 01day    16 adult female 05day    29 adult female 30day    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    26 Schneider line 2 Sg4    13 embryonic 1182-4H    16 embryonic GM2    12 embryonic Kc167    17 embryonic S1    23 embryonic S3    13 leg disc CME L1    14 wing disc CME-W2    14 wing disc ML-DmD8    18 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    14 wing disc ML-DmD21    13 wing disc ML-DmD32    10 haltere disc ML-DmD17-c3    16 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    20 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    16 ovary fGS/OSS    20 ovary OSC    14 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  26 Schneider line 2 Sg4    13 embryonic 1182-4H    16 embryonic GM2    12 embryonic Kc167    17 embryonic S1    23 embryonic S3    13 leg disc CME L1    14 wing disc CME-W2    14 wing disc ML-DmD8    18 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    14 wing disc ML-DmD21    13 wing disc ML-DmD32    10 haltere disc ML-DmD17-c3    16 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    20 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    16 ovary fGS/OSS    20 ovary OSC    14 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    26 Schneider line 2 Sg4    13 embryonic 1182-4H    16 embryonic GM2    12 embryonic Kc167    17 embryonic S1    23 embryonic S3    13 leg disc CME L1    14 wing disc CME-W2    14 wing disc ML-DmD8    18 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    14 wing disc ML-DmD21    13 wing disc ML-DmD32    10 haltere disc ML-DmD17-c3    16 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    20 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    16 ovary fGS/OSS    20 ovary OSC    14 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    26 Schneider line 2 Sg4    13 embryonic 1182-4H    16 embryonic GM2    12 embryonic Kc167    17 embryonic S1    23 embryonic S3    13 leg disc CME L1    14 wing disc CME-W2    14 wing disc ML-DmD8    18 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    14 wing disc ML-DmD21    13 wing disc ML-DmD32    10 haltere disc ML-DmD17-c3    16 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    20 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    16 ovary fGS/OSS    20 ovary OSC    14 ovary OSS    9 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    26 Schneider line 2 Sg4    13 embryonic 1182-4H    16 embryonic GM2    12 embryonic Kc167    17 embryonic S1    23 embryonic S3    13 leg disc CME L1    14 wing disc CME-W2    14 wing disc ML-DmD8    18 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    14 wing disc ML-DmD21    13 wing disc ML-DmD32    10 haltere disc ML-DmD17-c3    16 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    20 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    16 ovary fGS/OSS    20 ovary OSC    14 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  26 Schneider line 2 Sg4    13 embryonic 1182-4H    16 embryonic GM2    12 embryonic Kc167    17 embryonic S1    23 embryonic S3    13 leg disc CME L1    14 wing disc CME-W2    14 wing disc ML-DmD8    18 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    14 wing disc ML-DmD21    13 wing disc ML-DmD32    10 haltere disc ML-DmD17-c3    16 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    20 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    16 ovary fGS/OSS    20 ovary OSC    14 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    26 Schneider line 2 Sg4    13 embryonic 1182-4H    16 embryonic GM2    12 embryonic Kc167    17 embryonic S1    23 embryonic S3    13 leg disc CME L1    14 wing disc CME-W2    14 wing disc ML-DmD8    18 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    14 wing disc ML-DmD21    13 wing disc ML-DmD32    10 haltere disc ML-DmD17-c3    16 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    20 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    16 ovary fGS/OSS    20 ovary OSC    14 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    26 Schneider line 2 Sg4    13 embryonic 1182-4H    16 embryonic GM2    12 embryonic Kc167    17 embryonic S1    23 embryonic S3    13 leg disc CME L1    14 wing disc CME-W2    14 wing disc ML-DmD8    18 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    14 wing disc ML-DmD21    13 wing disc ML-DmD32    10 haltere disc ML-DmD17-c3    16 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    20 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    16 ovary fGS/OSS    20 ovary OSC    14 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    11 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    33 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    15 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    30 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    29 Caffeine 25 mg/ml 48 hrs, 4-day adult    13 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    11 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult  (33) Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    15 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3  (30) Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (29) Caffeine 25 mg/ml 48 hrs, 4-day adult    13 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    11 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    33 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    15 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    30 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    29 Caffeine 25 mg/ml 48 hrs, 4-day adult    13 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    11 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    33 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    15 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    30 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    29 Caffeine 25 mg/ml 48 hrs, 4-day adult    13 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    11 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    33 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    15 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    30 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    29 Caffeine 25 mg/ml 48 hrs, 4-day adult    13 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    11 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult  (33) Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    15 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3  30 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  29 Caffeine 25 mg/ml 48 hrs, 4-day adult    13 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    11 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    33 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    15 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    30 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    29 Caffeine 25 mg/ml 48 hrs, 4-day adult    13 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    11 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    33 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    15 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    30 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    29 Caffeine 25 mg/ml 48 hrs, 4-day adult    13 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_17 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0026597 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7926-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | embryonic stage, with Scer\GAL4arm.PS AxnEDDNmut.Scer\UAS.T:Avic\GFP lethal | embryonic stage, with Scer\GAL4ptc-559.1 AxnScer\UAS.T:Avic\GFP lethal | larval stage | recessive AxnS044230 lethal | recessive AxnS044230 viable Axn8-13 Axn8-66 Axn16-21 viable, with Scer\GAL4arm.PS AxnFGmut.Scer\UAS.T:Avic\GFP viable, with Scer\GAL4pnr-MD237 AxnGD1334 Other Phenotypes Allele cell shape defective | somatic clone | third instar larval stage AxnS044230 mitotic cell cycle defective | somatic clone Axnh neuroanatomy defective, with Scer\GAL4neur-GAL4-A101 AxnScer\UAS.cHa visible, with Scer\GAL471B AxnScer\UAS.cHa visible, with Scer\GAL4pnr-MD237 AxnGD1334 visible, with Scer\GAL4tsh-Gal4-1 AxnScer\UAS.cHa visible | somatic clone AxnS044230 Axnunspecified wild-type Axn8-13 Axn8-66 Axn16-21 Phenotype manifest in Allele abdominal sternite bristle, with Scer\GAL4tsh-Gal4-1 AxnScer\UAS.cHa adult abdomen, with Scer\GAL4tsh-Gal4-1 AxnScer\UAS.cHa adult abdomen & macrochaeta | somatic clone AxnS044230 adult abdomen | somatic clone AxnS044230 adult cuticle | ectopic | somatic clone Axnh adult heart, with Scer\GAL4tin.CΔ4 AxnScer\UAS.T:Avic\GFP denticle AxnA1 Axna.A1 denticle, with Scer\GAL4da.G32 AxnΔRGS.Scer\UAS AxnA1.Scer\UAS denticle | ectopic, with Scer\GAL4e22c AxnScer\UAS.T:Avic\GFP denticle | supernumerary, with AxnS044230, Scer\GAL4da.G32 AxnScer\UAS.cHa denticle | supernumerary, with AxnScer\UAS.cHa, Scer\GAL4da.G32 AxnS044230 denticle belt AxnS044230 AxndsRNA.cTa AxndsRNA.cHa denticle belt, with AxnS044230, Scer\GAL4da.G32 AxnScer\UAS.cHa AxnScer\UAS.T:Myr-Src64B,T:Zzzz\FLAG denticle belt, with AxnScer\UAS.cHa, Scer\GAL4da.G32 AxnS044230 denticle belt, with AxnScer\UAS.T:Myr-Src64B,T:Zzzz\FLAG, Scer\GAL4da.G32 AxnS044230 denticle belt, with Scer\GAL4da.G32 AxnScer\UAS.T:Myr-Src64B,T:Zzzz\FLAG denticle belt | germline clone AxnS044230 dorsal medial muscle, with Scer\GAL41151 AxnScer\UAS.T:Avic\GFP dorsal medial muscle, with Scer\GAL4ebd1.PB AxnScer\UAS.T:Avic\GFP embryonic/first instar larval cuticle AxnS044230 AxndsRNA.cTa Axnunspecified AxndsRNA.cHa embryonic/first instar larval cuticle, with Scer\GAL4arm.PS AxnScer\UAS.T:Avic\GFP embryonic/first instar larval cuticle, with Scer\GAL4e22c AxnScer\UAS.T:Avic\GFP embryonic/larval cuticle | embryonic stage, with Scer\GAL4arm.PS AxnEDDNmut.Scer\UAS.T:Avic\GFP embryonic/larval dorsal branch, with Scer\GAL4btl.PS AxnScer\UAS.cHa embryonic/larval dorsal trunk, with Scer\GAL4btl.PS AxnScer\UAS.cHa embryonic/larval lateral trunk, with Scer\GAL4btl.PS AxnScer\UAS.cHa embryonic epidermis AxnA1 Axna.A1 embryonic epidermis, with Scer\GAL4da.G32 AxnΔRGS.Scer\UAS AxnA1.Scer\UAS eye, with Scer\GAL4GMR.PF AxnA1.Scer\UAS eye | somatic clone Axnh Axnunspecified eye disc | somatic clone AxnE77 Axnh Axnunspecified follicle cell | somatic clone AxnS044230 follicle stem cell | somatic clone AxnS044230 frons | ectopic | somatic clone Axnh G1 phase | somatic clone AxnS044230 germline cyst | somatic clone AxnS044230 indirect flight muscle, with Scer\GAL41151 AxnScer\UAS.T:Avic\GFP indirect flight muscle, with Scer\GAL4ebd1.PB AxnScer\UAS.T:Avic\GFP intestinal stem cell | somatic clone AxnS044230 leg, with Scer\GAL4tsh-Gal4-1 AxnScer\UAS.cHa leg | ectopic AxnS044230 leg | somatic clone AxnS044230 macrochaeta | ectopic | somatic clone AxnS044230 mesothoracic tergum, with Scer\GAL4pnr-MD237 AxnGD1334 mesothoracic tergum | ectopic, with Scer\GAL4sd-SG29.1 AxnA2.Scer\UAS mitotic cell cycle | somatic clone Axnh morphogenetic furrow | somatic clone AxnE77 multidendritic neuron, with Scer\GAL4neur-GAL4-A101 AxnScer\UAS.cHa ovary | somatic clone, with Scer\GAL4Act5C.PP AxnA2.Scer\UAS photoreceptor cell | somatic clone Axnunspecified sternite, with Scer\GAL4tsh-Gal4-1 AxnScer\UAS.cHa tracheal tip cell | embryonic stage | supernumerary, with Scer\GAL4btl.PS AxnScer\UAS.cHa trichome of the posterior wing margin, with Scer\GAL4sd-SG29.1 AxnA2.Scer\UAS ventral thoracic disc, with Scer\GAL4Dll-md23 AxnScer\UAS.cHa wing, with Scer\GAL469B AxnΔRGS.Scer\UAS AxnA1.Scer\UAS wing, with Scer\GAL471B AxnScer\UAS.cHa wing, with Scer\GAL4ap-md544 AxnA2.Scer\UAS wing, with Scer\GAL4sd-SG29.1 AxnA2.Scer\UAS wing & chaeta | ectopic | somatic clone Axnunspecified wing | somatic clone AxnS044230 Axnunspecified wing | somatic clone, with Scer\GAL4vg.int2.1 AxnEDDNmut.Scer\UAS.T:Avic\GFP wing disc | somatic clone | third instar larval stage AxnS044230 wing margin, with Scer\GAL4sd-SG29.1 AxnA2.Scer\UAS wing margin, with Scer\GAL4vg.int2.1 AxnFGmut.Scer\UAS.T:Avic\GFP wing margin bristle | cell autonomous | ectopic | somatic clone AxnS044230 wing margin bristle | ectopic | somatic clone AxnS044230
Classical Alleles ( 9 )
For All Classical Alleles Show
Allele of Axn Class Mutagen Stocks Known lesion Axn16-21 chemical 1 Yes Axn8-66 chemical 1 Yes AxnEY10228 P-element activity 1 -- Axnf01654 piggyBac transposase 1 -- Axn8-13 chemical 0 Yes AxnE77 ethyl methanesulfonate 0 -- Axnh 0 -- AxnS044230 Delta2-3 P-element activity 0 Yes Axnunspecified 0 --
Alleles Carried on Transgenic Constructs ( 34 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Axn Class Mutagen Stocks Known lesion AxnScer\UAS.T:Avic\GFP in vitro construct - site directed mutagenesis 2 Yes AxnGD1334 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes AxnHM04012 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Axn1.MtnA.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes Axn2.MtnA.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes Axn3.MtnA.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes Axn330-642.Act5C in vitro construct - regulatory fusion 0 Yes Axn4.MtnA.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes Axn5.MtnA.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes Axn531-671 in vitro construct - RNAi 0 Yes Axn6.MtnA.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes Axn7.MtnA.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes Axn8.MtnA.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes Axna.531-671 in vitro construct - RNAi 0 Yes Axna.A1 in vitro construct 0 Yes AxnA1.Scer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes AxnA1.Scer\UAS in vitro construct - regulatory fusion 0 Yes AxnA1 in vitro construct 0 Yes AxnA2.hs in vitro construct - regulatory fusion 0 Yes AxnA2.Scer\UAS in vitro construct - regulatory fusion 0 Yes AxnAct5C.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes AxndsRNA.cBa in vitro construct - RNAi 0 Yes AxndsRNA.cHa in vitro construct - RNAi 0 Yes AxndsRNA.cTa in vitro construct - RNAi 0 Yes AxnEDDNmut.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - amino acid replacement in vitro construct - coding region fusion 0 Yes AxnFGmut.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes Axnhs.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes AxnM2.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes AxnM3.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes AxnM4.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes AxnMtnA.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes AxnScer\UAS.cHa in vitro construct - regulatory fusion 0 Yes AxnScer\UAS.T:Myr-Src64B,T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes AxnΔRGS.Scer\UAS in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)B81 (Szeged Stock Center, 1998-) Df(3R)X3F (Cook, 2006.1.31)
Not disrupted in	Df(3R)01215 (Cook, 2006.1.31) Df(3R)L127 (Szeged Stock Center, 1998-)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1334} NA P{TRiP.HM04012} NA P{UAS-Axn.A1} NA P{UAS-Axn.A2} NA P{UAS-Axn.EDDNmut.GFP} NA P{UAS-Axn.FGmut.GFP} NA P{UAS-Axn.GFP} NA P{UAS-Axn.H} NA P{UAS-Axn.M2.GFP} NA P{UAS-Axn.M3.GFP} NA P{UAS-Axn.M4.GFP} NA P{UAS-Axn.Myc} NA P{UAS-Axn.myr.FLAG} NA P{UAS-Axn.ΔRGS} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}AxnEY10228 NA miscellaneous insertions PBac{WH}Axnf01654 NA insertion of enhancer trap P{lacW}AxnS044230 No
Gene Ontology: Function, Process & Cellular Component ( 17 unique terms )
Terms Based on Experimental Evidence ( 14 terms )
Molecular Function
CV term Evidence References
beta-catenin binding inferred from physical interaction with arm (Kremer et al., 2010) protein kinase binding inferred from physical interaction with sgg (Kremer et al., 2010)
Biological Process
CV term Evidence References
eye-antennal disc morphogenesis inferred from mutant phenotype (Lee and Treisman, 2001) heart development inferred from mutant phenotype (Casad et al., 2012) imaginal disc-derived wing morphogenesis inferred from mutant phenotype (Willert et al., 1999) imaginal disc pattern formation inferred from mutant phenotype (Willert et al., 1999) negative regulation of Wnt receptor signaling pathway inferred from direct assay (Hendriksen et al., 2005) inferred from genetic interaction with Wnt2 (Willert et al., 1999) inferred from mutant phenotype (Willert et al., 1999) oogenesis inferred from mutant phenotype (Song and Xie, 2003) phagocytosis, engulfment inferred from mutant phenotype (Stroschein-Stevenson et al., 2006) somatic stem cell maintenance inferred from mutant phenotype (Song and Xie, 2003) Wnt receptor signaling pathway inferred from genetic interaction with pan (Lee and Treisman, 2001)
Cellular Component
CV term Evidence References
cytoplasm inferred from direct assay (Cong and Varmus, 2004, Fiedler et al., 2011) nucleus inferred from direct assay (Cong and Varmus, 2004) plasma membrane inferred from direct assay (Fiedler et al., 2011)
Terms Based on Predictions or Assertions ( 8 terms )
Molecular Function
CV term Evidence References
beta-catenin binding non-traceable author statement (Swiss-Prot Project Members, 2000.10.1) GTPase activator activity inferred from biological aspect of ancestor with PANTHER:PTN000090250 (assigned by RefGenome) (Gaudet et al., 2010) signal transducer activity inferred from electronic annotation with InterPro:IPR001158 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
negative regulation of Wnt receptor signaling pathway non-traceable author statement (Swiss-Prot Project Members, 2000.10.1) termination of G-protein coupled receptor signaling pathway inferred from electronic annotation with InterPro:IPR000342, InterPro:IPR016137 (FlyBase Curators et al., 2004-) Wnt receptor signaling pathway inferred from sequence or structural similarity with UniProtKB:O35625 (FlyBase, 1992-)
Cellular Component
CV term Evidence References
cytoplasm non-traceable author statement (Swiss-Prot Project Members, 2000.10.1) plasma membrane inferred from biological aspect of ancestor with PANTHER:PTN000090250 (assigned by RefGenome) (Gaudet et al., 2010)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Axn - CAP pull down, western blot, two hybrid (Yamazaki and Nusse, 2002) Axn - arm anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Axn - sgg anti tag coimmunoprecipitation, peptide massfingerprinting (Neumüller et al., 2012)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Axn allele Gene References Axn8-13 dsh (Penton et al., 2002) Axn8-66 dsh (Penton et al., 2002) Axn16-21 dsh (Penton et al., 2002) AxnA2.Scer\UAS arm (Tolwinski and Wieschaus, 2001) nmo (Zeng and Verheyen, 2004) Wnt2 (Willert et al., 1999) AxndsRNA.cTa arr (Tolwinski et al., 2003) AxnE77 CycE (Brumby et al., 2004) pan (Lee and Treisman, 2001) sgg (Collins and Treisman, 2000) AxnS044230 wg (Tolwinski et al., 2003) AxnScer\UAS.T:Avic\GFP tum (Jones and Bejsovec, 2005) Axnunspecified pygo (Parker et al., 2002) unspecified pygo (Cadigan, 2002.1.24)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 68421 DroID - A comprehensive database of gene and protein interactions. • FBgn0026597 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43565 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q9V407
Orthologs
OrthoDB Orthologs (45) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG63R465 Dipteran inclusive ortholog search EOG62BXHR Insect inclusive ortholog search EOG6BP06T Arthropod inclusive ortholog search EOG6P5HR5 Metazoa inclusive ortholog search EOG671695, EOG6HJ1W0
Orthologs in Drosophila Species (EOG63R465)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Axn     Drosophila simulans   Dsim\Axn Y   Drosophila sechellia   Dsec\GM12852 Y   Drosophila erecta   Dere\GG11721 Y   Drosophila yakuba   Dyak\GE10849 Y   Drosophila ananassae   Dana\GF22991 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA20694 Y   Drosophila persimilis   Dper\GL14019 Y   Drosophila willistoni   Dwil\GK13864 Y   Drosophila virilis   Dvir\GJ10774 Y   Drosophila mojavensis   Dmoj\GI24204 Y   Drosophila grimshawi   Dgri\GH19169 Y
Orthologs in non-Drosophila Dipterans (EOG62BXHR)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL003388   Anopheles gambiae Malaria mosquito  Agam\AGAP002123   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ001221
Orthologs in non-Dipteran Insects (EOG6BP06T)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB47277   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG008398   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH17573   Atta cephalotes Leafcutter ant  Acep\ACEP15865   Camponotus floridanus Florida carpenter ant  Cflo\CFLO15934   Camponotus floridanus Florida carpenter ant  Cflo\CFLO13884   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL20864   Linepithema humile Argentine ant  Lhum\LH20655   Pogonomyrmex barbatus Red harvester ant  Pbar\PB14593   Solenopsis invicta Red fire ant  Sinv\SINV21811   Acyrthosiphon pisum Pea aphid  Apim\ACYPI008356   Bombyx mori Silkmoth  Bmor\BGIBMGA007134   Pediculus humanus Human body louse  Phum\PHUM327400   Tribolium castaneum Red flour beetle  Tcas\Axn
Orthologs in non-Insect Arthropods (EOG6P5HR5)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_301655   Ixodes scapularis Deer tick  Isca\ISCW013850
Orthologs in non-Arthropod Metazoa (EOG671695, EOG6HJ1W0)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_001072gn   Danio rerio Zebrafish  Drer\axin1   Danio rerio Zebrafish  Drer\axin2   Xenopus tropicalis Western clawed frog  Xtro\axin2   Xenopus tropicalis Western clawed frog  Xtro\xarp   Xenopus tropicalis Western clawed frog  Xtro\axin1   Gallus gallus Domestic chicken  Ggal\AXIN2   Gallus gallus Domestic chicken  Ggal\AXIN1   Mus musculus House mouse  Mmus\Axin1   Mus musculus House mouse  Mmus\Axin2   Rattus norvegicus Norway rat  Rnor\Axin2   Rattus norvegicus Norway rat  Rnor\Axin1   Homo sapiens Human  Hsap\ENSG00000168646   Homo sapiens Human  Hsap\AXIN1
Human Orthologs (2)
Gene OMIM HGNC Hsap\ENSG00000168646     Hsap\AXIN1
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\Axn Drosophila sechellia Dsec\GM12852 Drosophila erecta Dere\GG11721 Drosophila yakuba Dyak\GE10849 Drosophila ananassae Dana\GF22991 Drosophila pseudoobscura pseudoobscura Dpse\GA20694 Drosophila persimilis Dper\GL14019 Drosophila willistoni Dwil\GK13864 Drosophila virilis Dvir\GJ10774 Drosophila mojavensis Dmoj\GI24204 Drosophila grimshawi Dgri\GH19169
Stocks & Reagents
Stocks Listed in FlyBase ( 8 )
Bloomington	31705 y1 v1; P{TRiP.HM04012}attP2 9520 w118; P{UAS-dsh.myc}3-8 Axn8-66 7224 w*; P{UAS-Axn.GFP}2/CyO; Ki1/TM3, Sb1 7225 w*; KrIf-1/CyO; P{UAS-Axn.GFP}3/TM3, Sb1 9523 w118; P{UAS-dsh.myc}1-16 Axn16-21/TM6B, Tb1 17649 y1 w67c23; P{EPgy2}AxnEY10228/TM3, Sb1 Ser1
Harvard	- PBac{WH}Axnf01654
VDRC	v7748 w1118; P{GD1334}v7748/TM3
Genomic Clones ( 1 )
	BACR07A18 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 89 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT13274 LD38584 RH74443
Other clones	FI19317
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH10808 HL08054 LD03259 LD03738 LD05394 LD06084 LD07021 LD10863 LD11090 LD11821 LD15995 LD16126 LD19270 LD31679 LD33775 LD35840 LD36889 LD38510 LD38522 LD38585 LD44001 RE08459 RE10076 RE15048 RE15061 RE26027 RE38821 RE41043 RE43969 RE73671 RE75138 RH25117 RH28644 RH29975 RH30374 RH50551 RH63301 SD08789
Other clones	1466 15025 32539 38974 45522 63595 102374 102816 108626 122438 144781 158809 165335 167308 181883 194450 CK01.42A.F1 CK01.67A.B12 CK01.68D.F10 CK01.113C.D5 EK050821 EK052640 EK055141 EK118350 EK122227 EK161123 EK190326 EK225539 EK235115 EK242617 EK245717 EK250948 EK261629 EK269516 EK286711 GH26903 LD12886 LD13381 RP004197498 RP004216058 RP004224365 RP004245781 RP004250513 RP004501106 RP004527900 RP004534974 RP004543984
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0026597 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43565
Antibody Information
	polyclonal (Willert et al., 1999, Peradziryi et al., 2011, Yamazaki and Nusse, 2002)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	dsRNA made from templates generated with primers directed against this gene. (Mosimann et al., 2006) dsRNA has been made from templates generated with primers directed against this gene. (Rives et al., 2006) S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells. (Stroschein-Stevenson et al., 2006) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) Mutations in Axn prevent photoreceptor differentiation and lead to tissue overgrowth in the eye disc, due to ectopic activation of the wg pathway. (Lee and Treisman, 2001) Axn negatively regulates wg signaling by downregulating the level of arm. (Hamada et al., 1999) Axn inhibits Wnt signalling. (Willert et al., 1999) Axn loss of function phenotypes are similar to wg overexpression phenotypes. Axn overexpression phenotypes are similar to wg loss of function phenotypes. (Willert et al., 1999)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_170457 NM_170458 NM_170459 NM_001144654 NM_001170302 NM_001276168 NM_001276169 RefSeq (Proteins) • NP_733336 NP_733337 NP_733338 NP_001138126 NP_001163773 NP_001263097 NP_001263098 DDBJ / EMBL / GenBank • AA699261 AAD24886 AAF21293 AAF56993 AAL39764 AAN14207 AAN14208 ACL83582 ACZ95067 AF086811 AF091813 AGB96476 AGB96477 AI519142 AW943432 AY069619 BI607382 CL526196 CZ484124 Entrez Gene - A searchable database of RefSeq genes. • 43565 UniProtKB/Swiss-Prot • Q9V407 UniProtKB/TrEMBL • A4V3M5 B7Z0S0 E1JJ18 Q8IMJ7 Q8T022
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Regulator of G protein signalling (IPR000342) DIX domain (IPR001158) Regulator of G-protein signaling, domain 1 (IPR024066) Axin beta-catenin binding (IPR014936) Regulator of G protein signalling superfamily (IPR016137)
Linkouts
	BioGRID - A database of protein and genetic interactions • 68421 DroID - A comprehensive database of gene and protein interactions. • FBgn0026597 DRSC - Results from RNAi screens. • FBgn0026597 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0026597 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7926-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0026597 FlyReactome - A curated knowledgebase of Drosophila melanogaster pathways • 85721 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43565 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /segment/axin1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43565 modMine - Data generated by the modENCODE project. • FBgn0026597 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q9V407
Synonyms & Secondary IDs ( 20 )
Reported As
Symbol Synonym	0442/30 (Deak et al., 1997) APC (Casad et al., 2012) axin (Kalderon, 2002, Quinn et al., 2004, Tolwinski and Wieschaus, 2004, Liu and Cadigan, 2003, Belenkaya et al., 2002, Bienz, 2002, Penton et al., 2002, Cadigan, 2002.1.24, Lee and Treisman, 2001, Lee et al., 2000, Bienz, 1999, Vincent et al., 2011, Carrera et al., 2008, Cliffe et al., 2004, Tolwinski, 2009, Sato et al., 2008) Axin (Egger-Adam and Katanaev, 2010, Tountas and Fortini, 2007, Tolwinski, 2007, Xin et al., 2011, Lee et al., 2009, Fiedler et al., 2011, Roberts et al., 2012, Casad et al., 2012, Mendoza-Topaz et al., 2011, Yamazaki and Nusse, 2002, Chang et al., 2008) axn (Brumby et al., 2004, Bartoszewski and Grosshans, 2003, Baonza and Freeman, 2002, Tolwinski and Wieschaus, 2001, DasGupta et al., 2005, Stroschein-Stevenson et al., 2006, DasGupta et al., 2007, Awofala et al., 2012, Smibert et al., 2012) Axn (Lai et al., 2007, Mosimann et al., 2006, Hayward et al., 2006, Hartmann et al., 2009, Toku et al., 2011, Chiang et al., 2009, Zimmerman et al., 2010, Friedman et al., 2011, Casad et al., 2012, Karim and Moore, 2011, Awofala et al., 2012) CG7926 (Ni et al., 2008, Awofala et al., 2012) dAxin (Zheng et al., 1999, Parker et al., 2002, Srahna et al., 2006, Gonsalves et al., 2011, Luo et al., 2007) Daxin (Baeg et al., 2004, Zeng and Verheyen, 2004, Yamazaki and Yanagawa, 2003, Rives et al., 2002, Yamazaki et al., 2000, Chihara and Hayashi, 2000, Yanagawa et al., 2000, Willert et al., 1999, Hendriksen et al., 2005) DAxin (Cong and Varmus, 2004, Rulifson et al., 2000) d-axin (Tomoyasu et al., 2000, Hamada, 1998.8.25, Hamada et al., 1999, ) D-Axin (Siegfried and Steitz, 2000, Hamada et al., 1999, Ruel et al., 1999) dAXIN (Li et al., 2002) din (Colton et al., 1999) GSK3β (Casad et al., 2012) l(3)S044230 (Hamada et al., 1999, )
Name Synonym	Axin (Bilder, 2001, Nusse, 2001, Behrens, 2000, Peifer and Polakis, 2000, Colton et al., 1999, Wehrli et al., 2007, Zimmerman et al., 2007, Heeg-Truesdell, 2006, Rives et al., 2006, Furlong, 2005, Clevers, 2006, Takacs et al., 2008, Egger-Adam and Katanaev, 2010, Kremer et al., 2010, Benchabane et al., 2011, Takacs et al., 2008, Alexandre et al., 2008, Wehrli et al., 2008, Marques, 2005, Hayward et al., 2006, Song et al., 2009, Muñoz-Descalzo et al., 2011, Chan et al., 2007, Blauwkamp et al., 2008, Herranz et al., 2008, Silver et al., 2007, Mitchell et al., 2008, Rafel and Milán, 2008, Peterson-Nedry et al., 2008, Chang et al., 2008, Xie et al., 2005, Kalamegham et al., 2007, Taniue et al., 2010, Jones et al., 2010, Roberts et al., 2011, Karim and Moore, 2011, Peradziryi et al., 2011, Awofala et al., 2012) axin (DasGupta et al., 2005, Stadeli, 2006, Thompson et al., 2008, Olson et al., 2011, Tyler and Baker, 2007, Estella and Mann, 2008, Baig-Lewis et al., 2007, Piddini and Vincent, 2009, Zimmerman et al., 2010, Silver et al., 2007, Tolwinski, 2009, Zhang et al., 2011) axn (Cliffe et al., 2004) D-axin (Wharton et al., 2000) daxin (Colton et al., 1999) Daxin (Matsubayashi et al., 2004, Lee et al., 2009, Zhang et al., 2011) dAxin (Kalamegham et al., 2007, Quijano et al., 2010, Quijano et al., 2011) d-Axin (Kalamegham et al., 2007) Dm Axin (Konikoff et al., 2010)
Secondary FlyBase IDs
	FBgn0028152
References ( 192 )
Generate a list of	All references relating to this gene ( 192 )
List References by type	Research paper  ( 107 ) Supplementary material  ( 8 ) Review  ( 31 ) Personal communication to FlyBase  ( 9 ) Abstract  ( 27 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 1 ) Conference report  ( 3 ) Stock list  ( 1 ) Protein sequence record  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 22 )
	Caviglia and Luschnig, 2013, Development 140(6): 1240--1249 The ETS domain transcriptional repressor Anterior open inhibits MAP kinase and Wingless signaling to couple tracheal cell fate with branch identity. [FBrf0220890] Awofala et al., 2012, Funct. Integr. Genomics 12(2): 305--315 Functional roles for redox genes in ethanol sensitivity in Drosophila. [FBrf0218408] Casad et al., 2012, Mol. Genet. Genomics 287(4): 351--360 Deletion of Siah-interacting protein gene in Drosophila causes cardiomyopathy. [FBrf0217871] Krauchunas et al., 2012, Dev. Biol. 370(1): 125--134 Protein phosphorylation changes reveal new candidates in the regulation of egg activation and early embryogenesis in D. melanogaster. [FBrf0219342] Neumüller et al., 2012, Genetics 190(3): 931--940 Stringent analysis of gene function and protein-protein interactions using fluorescently tagged genes. [FBrf0217811] Roberts et al., 2012, PLoS ONE 7(2): e31284 Defining Components of the ßcatenin Destruction Complex and Exploring Its Regulation and Mechanisms of Action during Development. [FBrf0217546] Vied et al., 2012, Dev. Cell 23(4): 836--848 Regulation of stem cells by intersecting gradients of long-range niche signals. [FBrf0219709] Fiedler et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(5): 1937--1942 Dishevelled interacts with the DIX domain polymerization interface of Axin to interfere with its function in down-regulating {beta}-catenin. [FBrf0212953] Friedman et al., 2011, Sci. Signal. 4(196): rs10 Proteomic and functional genomic landscape of receptor tyrosine kinase and ras to extracellular signal-regulated kinase signaling. [FBrf0216513] Gonsalves et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(15): 5954--5963 An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway. [FBrf0214389] Karim and Moore, 2011, J. Neurosci. 31(47): 17017--17027 Convergent local identity and topographic projection of sensory neurons. [FBrf0216770] Mendoza-Topaz et al., 2011, Open Biol. 1(3): 110013 The Adenomatous polyposis coli tumour suppressor is essential for Axin complex assembly and function and opposes Axin's interaction with Dishevelled. [FBrf0218486] Muñoz-Descalzo et al., 2011, Development 138(8): 1501--1506 Modulation of the ligand-independent traffic of Notch by Axin and Apc contributes to the activation of Armadillo in Drosophila. [FBrf0213312] Olson et al., 2011, EMBO Rep. 12(10): 1047--1054 Yan, an ETS-domain transcription factor, negatively modulates the Wingless pathway in the Drosophila eye. [FBrf0216277] Peradziryi et al., 2011, EMBO J. 30(18): 3729--3740 PTK7/Otk interacts with Wnts and inhibits canonical Wnt signalling. [FBrf0215241] Quijano et al., 2011, Genetics 189(3): 809--824 Wg Signaling via Zw3 and Mad Restricts Self-Renewal of Sensory Organ Precursor Cells in Drosophila. [FBrf0216675] Roberts et al., 2011, Mol. Biol. Cell 22(11): 1845--1863 Deconstructing the sscatenin destruction complex: mechanistic roles for the tumor suppressor APC in regulating Wnt signaling. [FBrf0213765] Swarup and Verheyen, 2011, Proc. Natl. Acad. Sci. U.S.A. 108(24): 9887--9892 Drosophila homeodomain-interacting protein kinase inhibits the Skp1-Cul1-F-box E3 ligase complex to dually promote Wingless and Hedgehog signaling. [FBrf0214241] Toku et al., 2011, Comput. Biol. Chem. 35(5): 282--292 Reconstruction and crosstalk of protein-protein interaction networks of Wnt and Hedgehog signaling in Drosophila melanogaster. [FBrf0216393] Vincent et al., 2011, Dev. Cell 21(2): 366--374 Steep differences in wingless signaling trigger myc-independent competitive cell interactions. [FBrf0214665] Xin et al., 2011, Development 138(22): 4955--4967 Erect Wing facilitates context-dependent Wnt/Wingless signaling by recruiting the cell-specific Armadillo-TCF adaptor Earthbound to chromatin. [FBrf0216486] Zhang et al., 2011, Nat. Cell Biol. 13(5): 623--629 RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling. [FBrf0218772] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...