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Gene Dmel\Apc2

General Information
Symbol	Dmel\Apc2	Species	D. melanogaster
Name	Adenomatous polyposis coli tumor suppressor homolog 2	Annotation symbol	CG6193
Feature type	protein_coding_gene	FlyBase ID	FBgn0026598
Gene Model Status	Current	Stock availability	13 publicly available
Also Known As	dAPC2, E-APC, D-APC2, APC
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	95E6-95E6	Sequence location	3R:19,989,690..19,994,041 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Adenomatous polyposis coli tumor suppressor homolog 2 is referred to in FlyBase by the symbol Dmel\Apc2 (CG6193, FBgn0026598). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding. There is experimental evidence for 16 unique biological process terms, many of which group under: system development; multicellular organismal development; embryonic development via the syncytial blastoderm; cellular process; cellular component organization or biogenesis; localization; biological regulation; embryo development ending in birth or egg hatching; cell adhesion; chitin-based cuticle development; regulation of Wnt receptor signaling pathway. 29 alleles are reported. The phenotypes of these alleles are annotated with: organ system; multicellular structure; non-connected developing system; portion of tissue; late extended germ band embryo; acellular anatomical structure; organ system subdivision; anatomical structure; extended germ band embryo; ovariole; cell part; adherens junction; embryonic/larval integumentary system; external compound sense organ; adult segment. It has one annotated transcript and one annotated polypeptide. Protein features are: Adenomatous polyposis coli protein, 15 residue repeat; Adenomatous polyposis coli protein, cysteine-rich repeat; Armadillo; Armadillo-like helical; Armadillo-type fold. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1630322_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Apc2. Gene sequence location is 3R:19989690..19994041.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	References Herranz et al., 2010, Mol. Ecol. 19(19): 4255--4264 Bakal et al., 2007, Science 316(5832): 1753--1756
FB2012_01	Transgenic Constructs P{UAS-Apc2.myr} Alleles Apc2[Scer\UAS.T:Src64B,T:Zzzz\FLAG] Sequence features HFA14115 BKN23844 References Peradziryi et al., 2011, EMBO J. 30(18): 3729--3740
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 95E6-95E6   Limits computationally determined from genome sequence between P{PZ}Syx1A06737&P{PZ}Syx1A10660 and P{PZ}crb07207&P{PZ}BRWD305842
Experimentally Determined Cytological Location
Cytogenetic map Notes References 95F-95F     (Yu, 1998.12.14) 95E-95F     (Hamada et al., 1999) 95F1-95F2   (determined by in situ hybridisation)   (McCartney et al., 1999) 95E-95E     (Ahmed, 1999.3.12)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Apc2 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Apc2-RA FBtr0084552  NM_058082   4092   1067
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Apc2-PA   FBpp0083937   116.7   1067   5.67     NP_477430   AAF56249
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Armadillo (IPR000225) Adenomatous polyposis coli protein, cysteine-rich repeat (IPR009223) Adenomatous polyposis coli protein, 15 residue repeat (IPR009240) Armadillo-like helical (IPR011989) Armadillo-type fold (IPR016024)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA539787   AA803211   AA816916   AA820962   AA951250   AE014297 AAF56249   AC008203   AF091430 AAD20985   AF113913 AAD40227   AI455563   AI511644   AI518023   AI530878   AI530887   AI530889   AY051719 AAK93143   BG639078   BI352374   BI366390   BI369944   BI371315   BI374031   BQ103724   BT044211   CA806996   CO178765   CO190098   CO265875   CO272132   CO281247   CO324676   CO326511   EC062713   EC222172   EC241303   EC241768   EC243714   EC256282   EC257961   EV578939   EV582998   EV596934   FD585859   FD586166   GH740958   GH742197   GH743157   GH745468   GH747326   GH748978   GH749258   GH755074   GH760129   GH761757   GH763405   GH764501   GH766818   GH768771   GH769051   GH772089   GH773671   GH774761   GH774920   GH775956   GH776829   GH778338   GH779819   GH782812   GH783505   GH784320   GH791276   GH795503   GH796079   GH797593   GH797820   GH798752   GH805644   GH806695   GH811092   GH811150   GH811660   GH812954   GH819446   GH823534   GH824059   GH824337   GH825168   GH826083   GH826718   GH827024   GH827982   GH830485   GH831353   GH831670   GH831728   GH832036   GH836131   GH836234   GH837414   GH842105   GH843460   GH846319   GH847778   GH850336   GH853269   GH853514   GH853928   GH856060   GH857761   GH860436   GH862780   GH864994   GH865660   GH866493   GH868504   GH868589   GH874438   GH876100   GH878142   GH880491   GH884687   GH887857   GH891799   GH893217   GH895576   GH897772   GH898424   GH899458   GH899982   GH901291   GH903098   GH905175   GH905477   GH910079   GH910571   GH913198   GH914013   GH916285   GH926582   GH927933   GH930925   GH931020   GH932794
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q961B0 Q9Y1T2
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage   organism | ubiquitous   (Hamada et al., 1999) embryonic stage 1 -- 5   organism | ubiquitous & uniform   (Hamada et al., 1999) larval stage   imaginal disc   (Hamada et al., 1999) wing disc   (Hamada et al., 1999) ventral thoracic disc   (Hamada et al., 1999) eye-antennal disc   (Hamada et al., 1999) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage   organism   (Hamada et al., 1999)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage   mesoderm   • membrane (Yu and Bienz, 1999) endoderm   • membrane (Yu and Bienz, 1999) ventral nerve cord   • membrane (Yu and Bienz, 1999) mitotic domain   • cell cortex (McCartney et al., 1999) embryonic epidermis   • cell cortex (McCartney et al., 1999) embryonic hindgut   • adherens junction (McCartney et al., 1999) embryonic hindgut   • apical plasma membrane (McCartney et al., 1999) epithelial cell   • adherens junction (McCartney et al., 1999) epithelial cell   • apical plasma membrane (McCartney et al., 1999) embryonic stage 4   embryonic cortex   • actin cap (Yu and Bienz, 1999) embryonic stage 4 -- 5   embryonic cortex   • apical plasma membrane (Yu et al., 1999) embryonic cycle 10 -- embryonic cycle 13   organism   • actin cytoskeleton (McCartney et al., 1999) embryonic cycle 12   organism   • centrosome (McCartney et al., 1999) embryonic stage 5 -- 6   cell   • cell cortex (McCartney et al., 1999) embryonic stage 5 -- 16   epithelium   • apical plasma membrane (Yu et al., 1999) embryonic stage 5 -- third instar larval stage   cell   • membrane (Yu and Bienz, 1999) embryonic stage 15   denticle field anlage   • apical plasma membrane (McCartney et al., 1999) larval stage   imaginal disc   • adherens junction (McCartney et al., 1999) imaginal disc   • apical plasma membrane (McCartney et al., 1999) third instar larval stage   salivary gland   • nuclear envelope (Yu and Bienz, 1999) embryonic/larval cuprophilic cell   • nuclear envelope (Yu and Bienz, 1999) imaginal disc   • plasma membrane (Yu and Bienz, 1999) wing disc | punctate   • plasma membrane (Yu and Bienz, 1999) eye disc posterior to the morphogenetic furrow   • plasma membrane (Yu and Bienz, 1999) eye disc anterior to the morphogenetic furrow   • plasma membrane (Yu and Bienz, 1999) embryonic/larval brain | restricted   (McCartney et al., 1999) Comment:dividing cells inner proliferation zone | restricted   (McCartney et al., 1999) Comment:dividing cells larval outer optic anlage | restricted   (McCartney et al., 1999) Comment:dividing cells neuroblast   (McCartney et al., 1999) midline glial cell   (McCartney et al., 1999)
Additional Descriptive Data
	Apc2 protein is localized to the apical plasma membrane in the newly formed epithelium of celluarizing embryos. (Yu et al., 1999) Apc2 protein is expressed in all embryonic cells, and at low levels in most larval tissues. In syncyctial blastoderms, Apc2 protein is localized to cortical actin caps that lie above each nucleus; costaining with antibodies to tubulin indicates at Apc2 protein does not bind direction to microtubules. As embryos cellularize, Apc2 protein delocalizes from the actin caps to become associated with membranes. (Yu and Bienz, 1999)
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0026598    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0026598 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0026598 expression level Developmental Stage   Expression Level embryo 00-02hr    4243 embryo 02-04hr    4799 embryo 04-06hr    2350 embryo 06-08hr    2145 embryo 08-10hr    1970 embryo 10-12hr    1122 embryo 12-14hr    789 embryo 14-16hr    765 embryo 16-18hr    552 embryo 18-20hr    327 embryo 20-22hr    373 embryo 22-24hr    542 larva L1    175 larva L2    173 larva L3 12hr old    194 larva L3 puffstage 1-2    368 larva L3 puffstage 3-6    502 larva L3 puffstage 7-9    679 white prepupae new    736 white prepupae 12hr    968 white prepupae 24hr    921 pupae 2d postWPP    420 pupae 3d postWPP    183 pupae 4d postWPP    342 adult male 01day    191 adult male 05day    231 adult male 30day    272 adult female 01day    894 adult female 05day    1807 adult female 30day    1971 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4243) embryo 02-04hr  (4799) embryo 04-06hr  (2350) embryo 06-08hr  (2145) embryo 08-10hr  (1970) embryo 10-12hr  (1122) embryo 12-14hr  (789) embryo 14-16hr  (765) embryo 16-18hr  (552) embryo 18-20hr  (327) embryo 20-22hr  (373) embryo 22-24hr  (542) larva L1  (175) larva L2  (173) larva L3 12hr old  (194) larva L3 puffstage 1-2  (368) larva L3 puffstage 3-6  (502) larva L3 puffstage 7-9  (679) white prepupae new  (736) white prepupae 12hr  (968) white prepupae 24hr  (921) pupae 2d postWPP  (420) pupae 3d postWPP  (183) pupae 4d postWPP  (342) adult male 01day  (191) adult male 05day  (231) adult male 30day  (272) adult female 01day  (894) adult female 05day  (1807) adult female 30day  (1971) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4243) embryo 02-04hr  (4799) embryo 04-06hr  (2350) embryo 06-08hr  (2145) embryo 08-10hr  (1970) embryo 10-12hr    1122 embryo 12-14hr    789 embryo 14-16hr    765 embryo 16-18hr    552 embryo 18-20hr    327 embryo 20-22hr    373 embryo 22-24hr    542 larva L1    175 larva L2    173 larva L3 12hr old    194 larva L3 puffstage 1-2    368 larva L3 puffstage 3-6    502 larva L3 puffstage 7-9    679 white prepupae new    736 white prepupae 12hr    968 white prepupae 24hr    921 pupae 2d postWPP    420 pupae 3d postWPP    183 pupae 4d postWPP    342 adult male 01day    191 adult male 05day    231 adult male 30day    272 adult female 01day    894 adult female 05day  (1807) adult female 30day  (1971) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4243 embryo 02-04hr    4799 embryo 04-06hr    2350 embryo 06-08hr    2145 embryo 08-10hr    1970 embryo 10-12hr    1122 embryo 12-14hr    789 embryo 14-16hr    765 embryo 16-18hr    552 embryo 18-20hr    327 embryo 20-22hr    373 embryo 22-24hr    542 larva L1    175 larva L2    173 larva L3 12hr old    194 larva L3 puffstage 1-2    368 larva L3 puffstage 3-6    502 larva L3 puffstage 7-9    679 white prepupae new    736 white prepupae 12hr    968 white prepupae 24hr    921 pupae 2d postWPP    420 pupae 3d postWPP    183 pupae 4d postWPP    342 adult male 01day    191 adult male 05day    231 adult male 30day    272 adult female 01day    894 adult female 05day    1807 adult female 30day    1971 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4243 embryo 02-04hr    4799 embryo 04-06hr    2350 embryo 06-08hr    2145 embryo 08-10hr    1970 embryo 10-12hr    1122 embryo 12-14hr    789 embryo 14-16hr    765 embryo 16-18hr    552 embryo 18-20hr    327 embryo 20-22hr    373 embryo 22-24hr    542 larva L1    175 larva L2    173 larva L3 12hr old    194 larva L3 puffstage 1-2    368 larva L3 puffstage 3-6    502 larva L3 puffstage 7-9    679 white prepupae new    736 white prepupae 12hr    968 white prepupae 24hr    921 pupae 2d postWPP    420 pupae 3d postWPP    183 pupae 4d postWPP    342 adult male 01day    191 adult male 05day    231 adult male 30day    272 adult female 01day    894 adult female 05day    1807 adult female 30day    1971 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0026598 expression level Developmental Stage   Expression Level embryo 00-02hr    4243 embryo 02-04hr    4799 embryo 04-06hr    2350 embryo 06-08hr    2145 embryo 08-10hr    1970 embryo 10-12hr    1122 embryo 12-14hr    789 embryo 14-16hr    765 embryo 16-18hr    552 embryo 18-20hr    327 embryo 20-22hr    373 embryo 22-24hr    542 larva L1    175 larva L2    173 larva L3 12hr old    194 larva L3 puffstage 1-2    368 larva L3 puffstage 3-6    502 larva L3 puffstage 7-9    679 white prepupae new    736 white prepupae 12hr    968 white prepupae 24hr    921 pupae 2d postWPP    420 pupae 3d postWPP    183 pupae 4d postWPP    342 adult male 01day    191 adult male 05day    231 adult male 30day    272 adult female 01day    894 adult female 05day    1807 adult female 30day    1971 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4243) embryo 02-04hr  (4799) embryo 04-06hr  (2350) embryo 06-08hr  (2145) embryo 08-10hr  (1970) embryo 10-12hr  (1122) embryo 12-14hr  (789) embryo 14-16hr  (765) embryo 16-18hr  (552) embryo 18-20hr  (327) embryo 20-22hr  (373) embryo 22-24hr  (542) larva L1  (175) larva L2  (173) larva L3 12hr old  (194) larva L3 puffstage 1-2  (368) larva L3 puffstage 3-6  (502) larva L3 puffstage 7-9  (679) white prepupae new  (736) white prepupae 12hr  (968) white prepupae 24hr  (921) pupae 2d postWPP  (420) pupae 3d postWPP  (183) pupae 4d postWPP  (342) adult male 01day  (191) adult male 05day  (231) adult male 30day  (272) adult female 01day  (894) adult female 05day  (1807) adult female 30day  (1971) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4243) embryo 02-04hr  (4799) embryo 04-06hr  2350 embryo 06-08hr  2145 embryo 08-10hr  1970 embryo 10-12hr    1122 embryo 12-14hr    789 embryo 14-16hr    765 embryo 16-18hr    552 embryo 18-20hr    327 embryo 20-22hr    373 embryo 22-24hr    542 larva L1    175 larva L2    173 larva L3 12hr old    194 larva L3 puffstage 1-2    368 larva L3 puffstage 3-6    502 larva L3 puffstage 7-9    679 white prepupae new    736 white prepupae 12hr    968 white prepupae 24hr    921 pupae 2d postWPP    420 pupae 3d postWPP    183 pupae 4d postWPP    342 adult male 01day    191 adult male 05day    231 adult male 30day    272 adult female 01day    894 adult female 05day  1807 adult female 30day  1971 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4243 embryo 02-04hr    4799 embryo 04-06hr    2350 embryo 06-08hr    2145 embryo 08-10hr    1970 embryo 10-12hr    1122 embryo 12-14hr    789 embryo 14-16hr    765 embryo 16-18hr    552 embryo 18-20hr    327 embryo 20-22hr    373 embryo 22-24hr    542 larva L1    175 larva L2    173 larva L3 12hr old    194 larva L3 puffstage 1-2    368 larva L3 puffstage 3-6    502 larva L3 puffstage 7-9    679 white prepupae new    736 white prepupae 12hr    968 white prepupae 24hr    921 pupae 2d postWPP    420 pupae 3d postWPP    183 pupae 4d postWPP    342 adult male 01day    191 adult male 05day    231 adult male 30day    272 adult female 01day    894 adult female 05day    1807 adult female 30day    1971 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4243 embryo 02-04hr    4799 embryo 04-06hr    2350 embryo 06-08hr    2145 embryo 08-10hr    1970 embryo 10-12hr    1122 embryo 12-14hr    789 embryo 14-16hr    765 embryo 16-18hr    552 embryo 18-20hr    327 embryo 20-22hr    373 embryo 22-24hr    542 larva L1    175 larva L2    173 larva L3 12hr old    194 larva L3 puffstage 1-2    368 larva L3 puffstage 3-6    502 larva L3 puffstage 7-9    679 white prepupae new    736 white prepupae 12hr    968 white prepupae 24hr    921 pupae 2d postWPP    420 pupae 3d postWPP    183 pupae 4d postWPP    342 adult male 01day    191 adult male 05day    231 adult male 30day    272 adult female 01day    894 adult female 05day    1807 adult female 30day    1971 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0026598    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0026598 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0026598 expression level Tissue   Expression Level Larval Central Nervous System    8.35 Larval Midgut    7.8 Larval Hindgut    5.1 Larval Malpighian Tubules    6.3 Larval Fat Body no informative data Larval Salivary Gland    9.7 Larval Trachea    9.25 Larval Carcass    7.95 Adult Head    4.4 Adult Eye    8.75 Adult Brain    3.6 Adult Thoracic-Abdominal Ganglion    5.2 Adult Crop no informative data Adult Midgut    8.7 Adult Hindgut    7.5 Adult Malpighian Tubules    3.5 Adult Fat Body    20.9 Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca    16.8 Adult InseminatedFemale Spermatheca    20.8 Adult Ovary    11.6 Adult Testis    5.1 Adult Male Accessory Gland no informative data Adult Carcass    5.6 Expression Level Scale  None   Low  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    8.35 Larval Midgut    7.8 Larval Hindgut    5.1 Larval Malpighian Tubules    6.3 Larval Fat Body no informative data Larval Salivary Gland    9.7 Larval Trachea    9.25 Larval Carcass    7.95 Adult Head    4.4 Adult Eye    8.75 Adult Brain    3.6 Adult Thoracic-Abdominal Ganglion    5.2 Adult Crop no informative data Adult Midgut    8.7 Adult Hindgut    7.5 Adult Malpighian Tubules    3.5 Adult Fat Body    20.9 Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca    16.8 Adult InseminatedFemale Spermatheca    20.8 Adult Ovary    11.6 Adult Testis    5.1 Adult Male Accessory Gland no informative data Adult Carcass    5.6 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    8.35 Larval Midgut    7.8 Larval Hindgut    5.1 Larval Malpighian Tubules    6.3 Larval Fat Body no informative data Larval Salivary Gland    9.7 Larval Trachea    9.25 Larval Carcass    7.95 Adult Head    4.4 Adult Eye    8.75 Adult Brain    3.6 Adult Thoracic-Abdominal Ganglion    5.2 Adult Crop no informative data Adult Midgut    8.7 Adult Hindgut    7.5 Adult Malpighian Tubules    3.5 Adult Fat Body    20.9 Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca    16.8 Adult InseminatedFemale Spermatheca    20.8 Adult Ovary    11.6 Adult Testis    5.1 Adult Male Accessory Gland no informative data Adult Carcass    5.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    8.35 Larval Midgut    7.8 Larval Hindgut    5.1 Larval Malpighian Tubules    6.3 Larval Fat Body no informative data Larval Salivary Gland    9.7 Larval Trachea    9.25 Larval Carcass    7.95 Adult Head    4.4 Adult Eye    8.75 Adult Brain    3.6 Adult Thoracic-Abdominal Ganglion    5.2 Adult Crop no informative data Adult Midgut    8.7 Adult Hindgut    7.5 Adult Malpighian Tubules    3.5 Adult Fat Body    20.9 Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca    16.8 Adult InseminatedFemale Spermatheca    20.8 Adult Ovary    11.6 Adult Testis    5.1 Adult Male Accessory Gland no informative data Adult Carcass    5.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0026598 expression level Tissue   Expression Level Larval Central Nervous System    8.35 Larval Midgut    7.8 Larval Hindgut    5.1 Larval Malpighian Tubules    6.3 Larval Fat Body no informative data Larval Salivary Gland    9.7 Larval Trachea    9.25 Larval Carcass    7.95 Adult Head    4.4 Adult Eye    8.75 Adult Brain    3.6 Adult Thoracic-Abdominal Ganglion    5.2 Adult Crop no informative data Adult Midgut    8.7 Adult Hindgut    7.5 Adult Malpighian Tubules    3.5 Adult Fat Body    20.9 Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca    16.8 Adult InseminatedFemale Spermatheca    20.8 Adult Ovary    11.6 Adult Testis    5.1 Adult Male Accessory Gland no informative data Adult Carcass    5.6 Expression Level Scale  None   Low  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    8.35 Larval Midgut    7.8 Larval Hindgut    5.1 Larval Malpighian Tubules    6.3 Larval Fat Body no informative data Larval Salivary Gland    9.7 Larval Trachea    9.25 Larval Carcass    7.95 Adult Head    4.4 Adult Eye    8.75 Adult Brain    3.6 Adult Thoracic-Abdominal Ganglion    5.2 Adult Crop no informative data Adult Midgut    8.7 Adult Hindgut    7.5 Adult Malpighian Tubules    3.5 Adult Fat Body    20.9 Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca    16.8 Adult InseminatedFemale Spermatheca    20.8 Adult Ovary    11.6 Adult Testis    5.1 Adult Male Accessory Gland no informative data Adult Carcass    5.6 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    8.35 Larval Midgut    7.8 Larval Hindgut    5.1 Larval Malpighian Tubules    6.3 Larval Fat Body no informative data Larval Salivary Gland    9.7 Larval Trachea    9.25 Larval Carcass    7.95 Adult Head    4.4 Adult Eye    8.75 Adult Brain    3.6 Adult Thoracic-Abdominal Ganglion    5.2 Adult Crop no informative data Adult Midgut    8.7 Adult Hindgut    7.5 Adult Malpighian Tubules    3.5 Adult Fat Body    20.9 Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca    16.8 Adult InseminatedFemale Spermatheca    20.8 Adult Ovary    11.6 Adult Testis    5.1 Adult Male Accessory Gland no informative data Adult Carcass    5.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    8.35 Larval Midgut    7.8 Larval Hindgut    5.1 Larval Malpighian Tubules    6.3 Larval Fat Body no informative data Larval Salivary Gland    9.7 Larval Trachea    9.25 Larval Carcass    7.95 Adult Head    4.4 Adult Eye    8.75 Adult Brain    3.6 Adult Thoracic-Abdominal Ganglion    5.2 Adult Crop no informative data Adult Midgut    8.7 Adult Hindgut    7.5 Adult Malpighian Tubules    3.5 Adult Fat Body    20.9 Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca    16.8 Adult InseminatedFemale Spermatheca    20.8 Adult Ovary    11.6 Adult Testis    5.1 Adult Male Accessory Gland no informative data Adult Carcass    5.6 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body no informative data Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop no informative data Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland no informative data Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    4.4   NA  Eye    8.75   NA  Brain    3.6   8.35  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    5.2   NA  Crop    no informative data   7.8  Midgut    8.7   5.1  Hindgut    7.5   6.3  Malpighian Tubules    3.5   no informative data  Fat Body    20.9   9.7  Salivary Gland    no informative data   NA  Heart    no informative data   9.25  Trachea    NA   NA  VirginFemale Spermatheca    16.8   NA  InseminatedFemale Spermatheca    20.8   NA  Ovary    11.6   NA  Testis    5.1   NA  Male Accessory Gland    no informative data   7.95  Carcass    5.6 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_17
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0026598 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6193-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | embryonic stage | maternal effect (with Df(3R)w6) Apc2d40 lethal | embryonic stage | maternal effect | recessive Apc2N175K lethal | embryonic stage | non-rescuable maternal effect | heat sensitive Apc2c9 lethal | embryonic stage | recessive | rescuable maternal effect Apc2d40 lethal | embryonic stage | rescuable maternal effect Apc2d40 Apc2f90 Apc2g10 Apc2g41 Apc2N175K lethal | embryonic stage | rescuable maternal effect | heat sensitive Apc2b5 Apc2e90 Apc2ΔS lethal | maternal effect | recessive Apc2d40 lethal | maternal effect | recessive | heat sensitive Apc2ΔS lethal | recessive | rescuable maternal effect | heat sensitive Apc2ΔS viable Apc2d40 Apc2f90 Apc2g10 Apc2N175K Apc2ΔS viable, with Scer\GAL4pnr-MD237 Apc2GD11854 viable, with Scer\GAL4pros.PMG Apc2Scer\UAS.T:Avic\GFP Sterility Allele sterile (with Apc2N175K) Apc2ΔS sterile (with Apc2ΔS) Apc2N175K sterile | recessive Apc2N175K Other Phenotypes Allele visible | recessive Apc2N175K wild-type Apc2+t7 Phenotype manifest in Allele abdominal lateral oblique muscle 1 founder cell Apc2d40 abdominal ventral acute muscle 1 founder cell | supernumerary Apc2ΔS Apc2d40 abdominal ventral acute muscle 2 founder cell | supernumerary Apc2ΔS Apc2d40 abdominal ventral acute muscle 3 founder cell | supernumerary Apc2ΔS Apc2d40 abdominal ventral transverse muscle 1 founder cell Apc2d40 actin filament | embryonic stage 4 | germline clone Apc2g10 chaeta Apc2N175K cortical actin cytoskeleton & syncytial blastoderm embryo | maternal effect Apc2ΔS Apc2d40 Apc2g10 denticle Apc2d40 denticle | heat sensitive Apc2ΔS denticle | supernumerary, with Scer\GAL4da.G32 Apc2Scer\UAS.T:Src64B,T:Zzzz\FLAG denticle belt Apc2ΔS Apc2243-956 Apc2N175K Apc2a.243-956 Apc233 denticle belt, with Scer\GAL4da.G32 Apc2Scer\UAS.T:Src64B,T:Zzzz\FLAG denticle belt | maternal effect Apc2N175K Apc2d40 Apc2f90 Apc2g10 Apc2g41 denticle belt | maternal effect | heat sensitive Apc2ΔS Apc2b5 Apc2c9 dorsal fine hair | heat sensitive Apc2ΔS egg chamber Apc2ΔS Apc2N175K embryonic/first instar larval cuticle Apc2d40 Apc2unspecified Apc233 embryonic/first instar larval cuticle | heat sensitive Apc2ΔS embryonic/first instar larval cuticle | maternal effect Apc2ΔS Apc2N175K Apc2d40 Apc2f90 Apc2g10 Apc2g41 embryonic/first instar larval cuticle | maternal effect (with Df(3R)w6) Apc2d40 embryonic/first instar larval cuticle | maternal effect | heat sensitive Apc2ΔS Apc2b5 Apc2c9 Apc2e90 embryonic epidermis Apc2243-956 Apc2a.243-956 epithelial cell Apc2dsRNA.cLa hub cell Apc2unspecified male germline stem cell & centrosome (with Apc2d40) Apc2ΔS male germline stem cell & centrosome (with Apc2ΔS) Apc2d40 male germline stem cell & spindle (with Apc2d40) Apc2ΔS male germline stem cell & spindle (with Apc2ΔS) Apc2d40 male germline stem cell | supernumerary Apc2unspecified midgut constriction 1 Apc2243-956 Apc2a.243-956 nucleus | embryonic stage 4 | germline clone Apc2ΔS Apc2N175K Apc2d40 Apc2g10 Apc2c9 nurse cell Apc2N175K nurse cell & plasma membrane Apc2N175K ommatidium Apc2N175K oocyte Apc2ΔS Apc2N175K plasma membrane Apc2N175K spindle & syncytial blastoderm embryo | maternal effect Apc2d40 Apc2g10 spindle | embryonic stage 4 | germline clone Apc2ΔS spot adherens junction Apc2N175K syncytial blastoderm embryo | germline clone Apc2ΔS Apc2d40 wing vein Apc2N175K
Classical Alleles ( 17 )
For All Classical Alleles Show
Allele of Apc2 Class Mutagen Stocks Known lesion Apc2c03232 piggyBac transposase 2 -- Apc2N175K loss of function allele ethyl methanesulfonate 2 Yes Apc2ΔS antimorphic allele - genetic evidence, hypomorphic allele - genetic evidence 2 Yes Apc2d40 antimorphic allele - genetic evidence, hypomorphic allele - genetic evidence ethyl methanesulfonate 1 Yes Apc2g10 amorphic allele - genetic evidence, loss of function allele ethyl methanesulfonate 0 Yes Apc2123 hypomorphic allele - genetic evidence Delta2-3 0 Yes Apc219-3 hypomorphic allele - genetic evidence Delta2-3 0 Yes Apc233 hypomorphic allele - genetic evidence Delta2-3 0 Yes Apc245 hypomorphic allele - genetic evidence Delta2-3 0 Yes Apc25-3 hypomorphic allele - genetic evidence Delta2-3 0 Yes Apc2b5 ethyl methanesulfonate 0 Yes Apc2c9 ethyl methanesulfonate 0 Yes Apc2e90 ethyl methanesulfonate 0 Yes Apc2f90 loss of function allele ethyl methanesulfonate 0 Yes Apc2g41 ethyl methanesulfonate 0 Yes Apc2G5028 hypomorphic allele - genetic evidence 0 Yes Apc2unspecified 0 --
Alleles Carried on Transgenic Constructs ( 12 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Apc2 Class Mutagen Stocks Known lesion Apc2GD11854 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Apc2HM05073 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Apc2HMS00194 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Apc2KK103652 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Apc2Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 1 Yes Apc2+t7 in vitro construct - genomic fragment 0 Yes Apc2243-956 in vitro construct - RNAi 0 Yes Apc2a.243-956 in vitro construct - RNAi 0 Yes Apc2cMa in vitro construct - regulatory fusion 0 Yes Apc2dsRNA.cLa in vitro construct - RNAi 0 Yes Apc2Scer\UAS.T:Src64B,T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Apc2Δ20rep.T:Ivir\HA1 in vitro construct - deletion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Apc2-79 (Takacs et al., 2008) Df(3R)ED6187 (Ryder and Roote, 2004.11.10) Df(3R)Exel6198 (Ryder, 2004.4.26) Df(3R)w6 (Ahmed et al., 2002)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11854} NA P{KK103652} NA P{TRiP.HM05073} NA P{TRiP.HMS00194} NA P{UAS-Apc2.GFP} NA P{UAS-Apc2.myr} NA characterization construct P{Apc2.M} NA P{Apc2+t7} NA P{Apc2Δ20rep} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{?EP}Apc25-3 NA P{?EP}Apc219-3 NA P{?EP}Apc245 NA P{?EP}Apc2123 NA P{?EPgy2}Apc233 NA PBac{PB}Apc2c03232 NA insertion of mobile activating element P{EP}Apc2G5028 NA
Gene Ontology: Function, Process & Cellular Component ( 37 unique terms )
Terms Based on Experimental Evidence ( 24 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with arm (McCartney et al., 1999, Webb et al., 2009) inferred from physical interaction with dia (Webb et al., 2009) inferred from physical interaction with Kap3 (Webb et al., 2009)
Biological Process
CV term Evidence References
axon guidance inferred from genetic interaction with Apc (Hayden et al., 2007) brain development inferred from genetic interaction with Apc (Akong et al., 2002) cell adhesion inferred from mutant phenotype (Hamada and Bienz, 2002) cell-cell adhesion inferred from genetic interaction with Apc (Hayden et al., 2007) chitin-based embryonic cuticle biosynthetic process inferred from mutant phenotype (McCartney et al., 2006) chitin-based larval cuticle pattern formation inferred from genetic interaction with Apc (Akong et al., 2002) establishment or maintenance of microtubule cytoskeleton polarity inferred from mutant phenotype (Mattie et al., 2010) head involution inferred from genetic interaction with Apc (Akong et al., 2002) imaginal disc pattern formation inferred from genetic interaction with Apc (Akong et al., 2002) medulla oblongata development inferred from genetic interaction with Apc (Hayden et al., 2007) negative regulation of Wnt receptor signaling pathway inferred from genetic interaction with Apc (Hayden et al., 2007) inferred from genetic interaction with wg (McCartney et al., 1999) neuroblast proliferation inferred from genetic interaction with Apc (Akong et al., 2002) oocyte localization involved in germarium-derived egg chamber formation inferred from genetic interaction with Apc (Hamada and Bienz, 2002) inferred from mutant phenotype (Hamada and Bienz, 2002) pseudocleavage involved in syncytial blastoderm formation inferred from mutant phenotype (Webb et al., 2009) regulation of Wnt receptor signaling pathway inferred from genetic interaction with Apc (Ahmed et al., 2002, Akong et al., 2002) inferred from mutant phenotype (Ahmed et al., 2002) syncytial nuclear migration inferred from mutant phenotype (McCartney et al., 2006)
Cellular Component
CV term Evidence References
colocalizes_with actin filament inferred from direct assay (Webb et al., 2009) apical cortex inferred from direct assay (Akong et al., 2002) cell cortex inferred from direct assay (McCartney et al., 2006, Akong et al., 2002) cleavage furrow inferred from direct assay (Akong et al., 2002) dendrite inferred from direct assay (Rolls et al., 2007) neuronal cell body inferred from direct assay (Rolls et al., 2007) protein complex inferred from physical interaction with dia (Webb et al., 2009)
Terms Based on Predictions or Assertions ( 14 terms )
Molecular Function
CV term Evidence References
beta-catenin binding inferred from electronic annotation with InterPro:IPR009240 (FlyBase Curators et al., 2004-) microtubule binding inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000)
Biological Process
CV term Evidence References
cell adhesion non-traceable author statement (Bienz, 2002) cytokinesis traceable author statement (Johnston and Gallant, 2002) establishment of mitotic spindle localization traceable author statement (Bienz, 2002, Gonczy, 2002) microtubule-based process inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000) traceable author statement (Bienz, 2002) negative regulation of transcription, DNA-dependent traceable author statement (Bienz, 2002) positive regulation of proteolysis traceable author statement (Bienz, 2002) Wnt receptor signaling pathway traceable author statement (Ostrowski et al., 2002)
Cellular Component
CV term Evidence References
adherens junction traceable author statement (Bienz, 2002, Johnston and Gallant, 2002) apicolateral plasma membrane traceable author statement (Tepass et al., 2001, Bienz, 2002) cytoplasm traceable author statement (Bienz, 2002) microtubule associated complex inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000) nucleus traceable author statement (Bienz, 2002)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Apc2 allele Gene References Apc2+t7 Apc (Ahmed et al., 2002) Apc2d40 Apc (Ahmed et al., 2002, Akong et al., 2002, Akong et al., 2002) Apc2g10 Apc (Akong et al., 2002, Akong et al., 2002) Apc2N175K Apc (Hamada and Bienz, 2002) Apc2Scer\UAS.T:Avic\GFP Apc (Akong et al., 2002) Apc2ΔS Apc (Akong et al., 2002, Akong et al., 2002) wg (McCartney et al., 1999) unspecified Apc (Takacs et al., 2008, Takacs et al., 2008) arm (Takacs et al., 2008)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 67803 DroID - A comprehensive database of gene and protein interactions. • FBgn0026598 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42871
Orthologs
Genome-wide drosophilid orthologs	Dana\GF16111 Dere\GG11262 Dgri\GH18502 Dmoj\GI24175 Dpse\GA19428 Dsec\GM26568 Dsim\GD21072 Dvir\GJ14208 Dwil\GK11381 Dyak\GE23455
Curated drosophilid orthologs	Dpse\GA19428
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • JA14291 Caenorhabditis japonica (nematode) CPIJ018110 Culex pipens (mosquito) RP41510 Caenorhabditis remanei (nematode) 108915 Capitella spl (polychaete worm) ENSDARP00000086108 Danio rerio (zebra fish) PP21821 Pristionchus pacificus (nematode) XP_971309.1 Tribolium castaneum (red flour beetle) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0240638 FBgn0213392 FBgn0201423 FBgn0192527 FBgn0181421 FBgn0079425 FBgn0161002 FBgn0146898 FBgn0125969 FBgn0103563 FBgn0093133
Stocks & Reagents
Stocks Listed in FlyBase ( 13 )
Bloomington	28585 y1 v1; P{TRiP.HM05073}attP2 6801 Apc2d40 ca1/TM3, Sb1 8815 w*; P{UAS-Apc2.GFP}3/TM3, Sb1 34875 y1 sc* v1; P{TRiP.HMS00194}attP2 11224 w1118; PBac{PB}Apc2c03232/TM6B, Tb1 5917 th1 st1 cu1 sr1 Apc2ΔS/TM6B, Tb1 7210 w*; P{neoFRT}82B P{πM}87E sr1 e1 Apc2N175K/TM3, Sb1 Ser1
Harvard	- PBac{PB}Apc2c03232
Kyoto	108486 th1 st1 cu1 sr1 Apc2ΔS/TM6B, Tb1
VDRC	v100104 P{KK103652}VIE-260B v22290 w1118 P{GD11854}v22290 v22289 w1118; P{GD11854}v22289
	More stocks available...
Genomic Clones ( 1 )
	BACR29F06 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 136 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD24920
Other clones	FI05284
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GM10405 GM19011 LD18122 LD21721 LD31622 LD37423 LD43120 RE51917 RE56287 RE58182 RE61539 SD01634 SD01649 SD01652
Other clones	7978 39223 57455 214343.12 214443.6 CK01.57B.H9 CK01.72C.E11 Dmel_dig_005871_0659_2663 Dmel_dig_014905_0647_1355 Dmel_neb_016584_0939_0480 EK046531 EK057518 EK105960 EK144310 EK156262 EK194510 EP04036 ESG015d.E21.1_E04 RM02251 RM02451 RP001002550 RP001005053 RP001008431 RP001010730 RP001013133 RP001013498 RP001017180 RP001043245 RP001047384 RP001051156 RP001052992 RP001053816 RP003010718 RP003011738 RP003018096 RP003033043 RP003033358 RP003040831 RP003040994 RP003041420 RP003042588 RP003055635 RP003065238 RP003068565 RP003080008 RP003096307 RP003101074 RP003101839 RP003106203 RP003107869 RP003111578 RP003111965 RP003128843 RP003133501 RP003143968 RP003144817 RP003166157 RP003171651 RP003171772 RP003179500 RP003198343 RP003203982 RP003204983 RP003206608 RP003213996 RP003214231 RP003215419 RP003220203 RP003234280 RP003244980 RP003245357 RP003251902 RP003268547 RP003271902 RP003276736 RP003289092 RP003297587 RP003298723 RP003311746 RP003314600 RP003329964 RP003330479 RP003335080 RP003337463 RP003338537 RP003349522 RP003375290 RP003377403 RP003378565 RP003380170 RP003381177 RP003384806 RP003386233 RP003406456 RP003414709 RP003455122 RP003463754 RP003467080 RP003471904 RP003479520 RP003489759 RP003491547 RP003497394 RP003531037 RP003531428 RP003551387 RP003569158 RP003576400 RP003579216 RP003589155 RP003593997 RP003607162 RP003612928 RP003619943 RP003633931 RP003645252 RP003658318 RP003675093 RP003676622 UUGC1135
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0026598 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42871
Antibody Information
	polyclonal (Yu and Bienz, 1999, McCartney et al., 1999)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Apc2 CG6193 (Kodira, 1999.11)
Source for database merge of
Additional comments
Other Comments
	Apc and Apc2 are required in intestinal stem cells in the adult midgut to regulate proliferation. (Lee et al., 2009) dsRNA made from templates generated with primers directed against this gene. (Mosimann et al., 2006) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) Apc2 is a negative regulator of wg signaling in the embryonic epidermis. (McCartney et al., 1999) Identification: Isolated in a yeast two hybrid screen that used arm protein as the bait. (Yu et al., 1999) Interference with Apc2 function causes phenotypes like those of sgg mutants. (Yu et al., 1999)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_058082 RefSeq (Proteins) • NP_477430 DDBJ / EMBL / GenBank • AA539787 AA820962 AAD20985 AAD40227 AAF56249 AAK93143 AC008203 AF091430 AF113913 AI455563 AY051719 Entrez Gene - A searchable database of RefSeq genes. • 42871 UniProtKB/TrEMBL • Q9Y1T2 Q961B0
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Armadillo (IPR000225) Adenomatous polyposis coli protein, cysteine-rich repeat (IPR009223) Adenomatous polyposis coli protein, 15 residue repeat (IPR009240) Armadillo-like helical (IPR011989) Armadillo-type fold (IPR016024)
Linkouts
	BioGRID - A database of protein and genetic interactions • 67803 DroID - A comprehensive database of gene and protein interactions. • FBgn0026598 DRSC - Results from RNAi screens. • FBgn0026598 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0026598 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6193-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0026598 FlyReactome - A curated knowledgebase of Drosophila melanogaster pathways • 205598 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42871 InParanoid A subset of ortholog calls from InParanoid. • JA14291 Caenorhabditis japonica (nematode) CPIJ018110 Culex pipens (mosquito) RP41510 Caenorhabditis remanei (nematode) 108915 Capitella spl (polychaete worm) ENSDARP00000086108 Danio rerio (zebra fish) PP21821 Pristionchus pacificus (nematode) XP_971309.1 Tribolium castaneum (red flour beetle) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /segment/apctwo1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42871 modMine - Data generated by the modENCODE project. • FBgn0026598 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0240638 FBgn0213392 FBgn0201423 FBgn0192527 FBgn0181421 FBgn0079425 FBgn0161002 FBgn0146898 FBgn0125969 FBgn0103563 FBgn0093133
Synonyms & Secondary IDs ( 18 )
Reported As
Symbol Synonym	APC (Perez-Moreno et al., 2003, McNally, 2001) APC2 (Xi, 2005, McCartney and Peifer, 2003, Roegiers and Jan, 2004, Subramanian et al., 2003, Akong et al., 2002, Akong et al., 2002, McEwen and Peifer, 2001, Zimmerman et al., 2006, Webb et al., 2007, Zhou et al., 2007, Zimmerman et al., 2007, McCartney et al., 2006, Mosimann et al., 2006, Nystul and Spradling, 2006, He and Axelrod, 2006, Fuller and Spradling, 2007, Hayden et al., 2007, Bakal et al., 2007, Zhou et al., 2008, Zimmerman et al., 2008, Lu et al., 2008, Lin, 2008, Buttrick et al., 2008, Rusan et al., 2008, Price et al., 2006, Webb et al., 2009, Sheng et al., 2009, Viquez et al., 2009, Zimmerman et al., 2010, Kazgan et al., 2010) apc2 (Tolwinski and Wieschaus, 2004, Yamashita et al., 2004, Yamashita et al., 2003, Yamashita et al., 2003, Yamashita et al., 2005, Yamashita and Fuller, 2008, Tolwinski, 2009, Cheng et al., 2011) Apc2 (Takacs et al., 2008, Stone et al., 2010, Ahmed et al., 2002, Benchabane et al., 2011, Hueber et al., 2007, Takacs et al., 2008, Bakal et al., 2007, Yamashita et al., 2005, Weaver and Krasnow, 2008, Cao et al., 2007, Benchabane et al., 2008, Yang et al., 2008, Webb et al., 2009, Lee et al., 2009, Rolls et al., 2007, Cao et al., 2010, Pospisilik et al., 2010, Mattie et al., 2010) CG6193 (Goldstein and Gunawardena, 2000, Keleman et al., 2009.8.5, Perkins et al., 2009, Ni et al., 2011.7.19) dAPC2 (Cox and Baylies, 2005, Delon et al., 2003, Humbert et al., 2003, Gonczy, 2002, Bienz, 2002, Ostrowski et al., 2002, Kramps et al., 2002, Akong et al., 2002, Tepass et al., 2001, McCartney et al., 2001, Price et al., 2001, Akong et al., 2001, Townsley and Bienz, 2000, Peifer and Polakis, 2000, McCartney et al., 2000, Roose and Clevers, 1999, McCartney et al., 1999, Kirkpatrick, 1998.9.11, Wells, 1999, McCartney et al., 1999, Cliffe et al., 2004, Quijano et al., 2010, Bhandari and Shashidhara, 2001) dApc2 (Bienz and Clevers, 2000, van Es et al., 1999, van Es et al., 1999, Mieszczanek et al., 2008) D-APC2 (Siegfried and Steitz, 2000, Wharton et al., 2000, Ahmed et al., 1999) d-APC2 (Hamada et al., 1999) dAPC2/E-APC (Mimori-Kiyosue and Tsukita, 2001) Dm APC2 (Konikoff et al., 2010) E-APC (He, 2003, Hamada and Bienz, 2002, Bienz, 2001, Perez-Moreno et al., 2003, Barth and Nelson, 2002, Bienz, 2002, Tepass et al., 2001, Lu et al., 2001, Bienz and Clevers, 2000, Townsley and Bienz, 2000, Rosin-Arbesfeld et al., 2000, Ferkey and Kimelman, 2000, Seidensticker and Behrens, 2000, Yu, 1998.12.14, Wells, 1999, Yu et al., 1999, Hamada et al., 1999, Bienz, 1999, Yu and Bienz, 1999, Cliffe et al., 2004, Tran et al., 2008) E-APC dAPC2 (Bienz and Hamada, 2004)
Name Synonym	adenomatous polyposis coli 2 (Lin, 2008) Adenomatous polyposis coli 2 (Yamashita and Fuller, 2008) Adenomatous Polyposis Coli 2 (Sheng et al., 2009) Adenomatous polyposis coli tumor suppressor homolog 2   Epithelial Adenomatous Polyposis Coli
Secondary FlyBase IDs
References ( 146 )
Generate a list of	All references relating to this gene ( 146 )
List References by type	Research paper  ( 57 ) Supplementary material  ( 10 ) Review  ( 27 ) Personal communication to FlyBase  ( 10 ) Abstract  ( 31 ) FlyBase analysis  ( 2 ) Conference report  ( 2 ) DNA/RNA sequence record  ( 2 ) Meeting report  ( 1 ) Curated genome annotation  ( 2 ) Computer file  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 10 )
	Cheng et al., 2011, Development 138(5): 831--837 Asymmetric division of cyst stem cells in Drosophila testis is ensured by anaphase spindle repositioning. [FBrf0213009] Peradziryi et al., 2011, EMBO J. 30(18): 3729--3740 PTK7/Otk interacts with Wnts and inhibits canonical Wnt signalling. [FBrf0215241] Cao et al., 2010, Curr. Biol. 20(8): 770--776 Cortical Actin Dynamics Facilitate Early-Stage Centrosome Separation. [FBrf0211162] Kazgan et al., 2010, Mol. Biol. Cell 21(19): 3433--3442 Identification of a nuclear export signal in the catalytic subunit of AMP-activated protein kinase. [FBrf0211940] Konikoff et al., 2010, J. Mol. Evol. 70(4): 303--312 Distinct molecular evolutionary mechanisms underlie the functional diversification of the Wnt and TGFbeta signaling pathways. [FBrf0210842] Mattie et al., 2010, Curr. Biol. 20(24): 2169--2177 Directed Microtubule Growth, +TIPs, and Kinesin-2 Are Required for Uniform Microtubule Polarity in Dendrites. [FBrf0212550] Pospisilik et al., 2010, Cell 140(1): 148--160 Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate. [FBrf0212676] Quijano et al., 2010, PLoS ONE 5(7): e11619 The Sno Oncogene Antagonizes Wingless Signaling during Wing Development in Drosophila. [FBrf0211340] Stone et al., 2010, Mol. Biol. Cell 21(5): 767--777 Global Up-Regulation of Microtubule Dynamics and Polarity Reversal during Regeneration of an Axon from a Dendrite. [FBrf0210095] Zimmerman et al., 2010, Dev. Biol. 340(1): 54--66 Apical constriction and invagination downstream of the canonical Wnt signaling pathway require Rho1 and Myosin II. [FBrf0210185] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...