FB2021_02, released April 13, 2021

Gene: Dmel\MagR

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General Information
Symbol
Dmel\MagR
Species
D. melanogaster
Name
Magnetic receptor
Annotation Symbol
CG8198
Feature Type
protein_coding_gene
FlyBase ID
FBgn0026666
Gene Model Status
Current
Stock Availability
4 publicly available
Gene Summary
Involved in the assembly of mitochondrial iron-sulfur proteins. Probably involved in the binding of an intermediate of Fe/S cluster assembly (By similarity). Required for maintenance of circadian rhythms under constant darkness (PubMed:22885802). (UniProt, Q8T3X9)
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

l(1)G0136

Key Links
Genomic Location
Cytogenetic map
13E12-13E12
Sequence location
X:15,734,270..15,735,780 [+]
Recombination map
1-51
RefSeq locus
NC_004354 REGION:15734270..15735780
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (7 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables 2 iron, 2 sulfur cluster binding
inferred from biological aspect of ancestor with PANTHER:PTN001601055
(assigned by GO_Central )
(Gaudet et al., 2011)
enables structural molecule activity
inferred from electronic annotation with InterPro:IPR016092
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Biological Process (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
involved_in response to magnetism
inferred from direct assay
(Qin et al., 2016)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in iron-sulfur cluster assembly
inferred from biological aspect of ancestor with PANTHER:PTN001601055
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in protein maturation by iron-sulfur cluster transfer
inferred from biological aspect of ancestor with PANTHER:PTN001601055
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
located_in cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN001601055
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in mitochondrion
inferred from biological aspect of ancestor with PANTHER:PTN000007993
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the HesB/IscA family. (Q8T3X9)
Protein Signatures (InterPro)
Summaries
Protein Function (UniProtKB)
Involved in the assembly of mitochondrial iron-sulfur proteins. Probably involved in the binding of an intermediate of Fe/S cluster assembly (By similarity). Required for maintenance of circadian rhythms under constant darkness (PubMed:22885802).
(UniProt, Q8T3X9)
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\MagR for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.45

Sequence Ontology: Class of Gene
gene_with_edited_transcript
(Graveley et al., 2011)
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
MagR-RA
FBtr0074084
NM_132834
780
130
MagR-RB
FBtr0332613
NM_001272650
783
131
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
MagR-PA
FBpp0073900
14.1
130
9.64
NP_573062
AAF48498
MagR-PB
FBpp0304862
14.2
131
9.64
NP_001259579
AGB95421
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Interacts with cry.

(UniProt, Q8T3X9)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\MagR using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
• membrane
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\MagR in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 2 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of MagR
Transgenic constructs containing regulatory region of MagR
Aberrations (Deficiencies and Duplications) ( 2 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal | larval stage
lethal | prepupal stage
lethal | pupal stage
lethal | recessive
Other Phenotypes
Allele
abnormal locomotor rhythm, with Scer\GAL4tim.PE
Phenotype manifest in
Allele
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (2)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\ISCA1
13 of 15
Yes
Yes
Hsap\ISCA2
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\AK157302
11 of 15
Yes
Yes
Mmus\Isca1
8 of 15
No
Yes
Mmus\Isca2
1 of 15
No
No
Rattus norvegicus (Norway rat) (2)
Rnor\Isca1
12 of 13
Yes
Yes
Rnor\Isca2
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (1)
Xtro\isca1
8 of 12
Yes
Yes
Danio rerio (Zebrafish) (2)
Drer\isca1
13 of 15
Yes
Yes
Drer\isca2
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (2)
Cele\Y39B6A.3
13 of 15
Yes
Yes
Cele\Y54G11A.9
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (3)
Atha\AT2G16710
8 of 9
Yes
Yes
Atha\AT2G36260
7 of 9
No
Yes
Atha\CPISCA
1 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (2)
Scer\ISA1
9 of 15
Yes
Yes
Scer\ISA2
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\isa1
10 of 12
Yes
Yes
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190JF7 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00005914
Drosophila simulans
Dsim\GD17232
Drosophila sechellia
Dsec\GM22570
Drosophila erecta
Dere\GG17904
Drosophila yakuba
Dyak\GE17212
Drosophila ananassae
Dana\GF21925
Drosophila pseudoobscura pseudoobscura
Dpse\GA20890
Drosophila persimilis
Dper\GL16489
Drosophila willistoni
Dwil\GK25017
Drosophila virilis
Dvir\GJ16900
Drosophila mojavensis
Dmoj\GI16259
Drosophila grimshawi
Dgri\GH24545
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150GLV )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17010571
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_00395
Mayetiola destructor
Hessian fly
Mdes\Mdes015885
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL000418
Anopheles darlingi
American malaria mosquito
Adar\ADAC004984
Anopheles gambiae
Malaria mosquito
Agam\AGAP002730
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ002856
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0L5O )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA009980
Danaus plexippus
Monarch butterfly
Dple\DPOGS202462-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL015644
Apis florea
Little honeybee
Aflo\3139481060
Apis mellifera
Western honey bee
Amel\LOC552616
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP11019
Bombus terrestris
Buff-tailed bumblebee
Bter\15210532
Linepithema humile
Argentine ant
Lhum\LH12800
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG001099
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_07709
Tribolium castaneum
Red flour beetle
Tcas\TC011316
Pediculus humanus
Human body louse
Phum\PHUM155090
Rhodnius prolixus
Kissing bug
Rpro\RPRC007983
Cimex lectularius
Bed bug
Clec\CLEC013651
Cimex lectularius
Bed bug
Clec\CLEC000295
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI006095
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_07695
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0LCW )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR014169
Ixodes scapularis
Black-legged tick
Isca\ISCW024242
Ixodes scapularis
Black-legged tick
Isca\ISCW017935
Stegodyphus mimosarum
African social velvet spider
Smim\KFM57083.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur21g01770
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_303520
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0YHY )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Hbld2
Gallus gallus
Domestic chicken
Ggal\ISCA1
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (1)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
CG13623
2 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    ISCA1; iron-sulfur cluster assembly 1
    13 of 15
    611006
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser
    View in Interactions Browser
    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    MagR - cry
    pull down, molecular weight estimation by staining
    (Qin et al., 2016)
    Summary of Genetic Interactions
    esyN Network Diagram
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Subunit Structure (UniProtKB)
    Interacts with cry.
    (UniProt, Q8T3X9 )
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    External Data
    Linkouts
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    X
    Recombination map
    1-51
    Cytogenetic map
    13E12-13E12
    Sequence location
    X:15,734,270..15,735,780 [+]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    13E12-13E12
    Limits computationally determined from genome sequence between P{EP}EP1489 and P{EP}BEST:RE35685EP1581&P{EP}sdEP1088
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    13E8-13E9
    (determined by in situ hybridisation)
    (Peter et al., 2002, Schäfer et al., 1999.3.29)
    Experimentally Determined Recombination Data
    Location

    1-51

    (FlyBase, 2016)

    1-51.9

    (Comeron et al., 2012)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (4)
    Genomic Clones (9)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (5)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    BDGP DGC clones
    Other clones
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
     
    Commercially Available Antibodies
     
    Other Information
    Relationship to Other Genes
    Source for database identify of

    Source for identity of: MagR l(1)G0136

    (Qin et al., 2016)
    Source for database merge of

    Source for merge of: l(1)G0136 CG8198

    (Peter et al., 2002)

    Source for merge of: CG8198 BcDNA:AT26381

    (FlyBase, 1996-)
    Additional comments

    Source for merge of CG8198 BcDNA:AT26381 was a shared cDNA ( date:030728 ).

    (FlyBase, 1996-)
    Other Comments

    Candidate stable intronic sequence RNA (sisRNA) identified within CDS of this gene.

    (Pek et al., 2015)

    RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.

    (Boutros et al., 2004)
    Origin and Etymology
    Discoverer
    Etymology
    Identification
    External Crossreferences and Linkouts ( 36 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
    Other crossreferences
    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    Flygut - An atlas of the Drosophila adult midgut
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    InterPro - A database of protein families, domains and functional sites
    KEGG Genes - Molecular building blocks of life in the genomic space.
    modMine - A data warehouse for the modENCODE project
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DPiM - Drosophila Protein interaction map
    DroID - A comprehensive database of gene and protein interactions.
    DRSC - Results frm RNAi screens
    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
    FlyMine - An integrated database for Drosophila genomics
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    Synonyms and Secondary IDs (11)
    Datasets (0)
    Study focus (0)
    Experimental Role
    Project
    Project Type
    Title
    References (32)