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Gene Dmel\CSN5

General Information
Symbol	Dmel\CSN5	Species	D. melanogaster
Name	COP9 complex homolog subunit 5	Annotation symbol	CG14884
Feature type	protein_coding_gene	FlyBase ID	FBgn0027053
Gene Model Status	Current	Stock availability	3 publicly available
Also Known As	Dch5, jab1/csn5, Jab1, l(3)L4032
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	89B17-89B17	Sequence location	3R:12,295,823..12,297,128 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene COP9 complex homolog subunit 5 is referred to in FlyBase by the symbol Dmel\CSN5 (CG14884, FBgn0027053). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding; NEDD8 activating enzyme activity. There is experimental evidence for 11 unique biological process terms, many of which group under: biological regulation; neuron differentiation; system development; multicellular organism reproduction; macromolecule modification; cellular component organization or biogenesis; localization; gamete generation; anterior/posterior axis specification; sensory organ development; dorsal/ventral axis specification. 32 alleles are reported. The phenotypes of these alleles are annotated with: lamina anlage glial cell; larva; pupa; ovary; embryonic/larval optic neuropil; wing; germarium; melanotic mass; dorsal appendage; nurse cell. It has one annotated transcript and one annotated polypeptide. Protein features are: Mov34/MPN/PAD-1. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages, during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1632776_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CSN5. Gene sequence location is 3R:12295823..12297128.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	References Gemmill et al., 2005, Oncogene 24(21): 3503--3511
FB2012_01	Sequence features BKN20306 HFA16592
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 89B17-89B17   Limits computationally determined from genome sequence between P{PZ}gish04895&P{EP}EP3171 and P{lacW}CSN5L4032
Experimentally Determined Cytological Location
Cytogenetic map Notes References 89D1-89D2     (Freilich et al., 1999) 89D1-89D2   (determined by in situ hybridisation)   (Spradling et al., 1999) 89D1-89D2     (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CSN5 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CSN5-RA FBtr0083292  NM_058094   1194   327
Additional Transcript Data & Comments
Reported size (kB)	1.198 (longest cDNA) (Freilich et al., 1999)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CSN5-PA   FBpp0082743   37.1   327   5.28     NP_477442   AAF55321
Additional Polypeptide Data & Comments
Reported size (kDa)	327 (aa) (Freilich et al., 1999)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Mov34/MPN/PAD-1 (IPR000555)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA439751   AA540077   AA949183   AE014297 AAF55321   AC011615   AF129083 AAD28608   AF132563 AAD27862   AI389593   AI455897   AI456838   AI516182   AI518449   AI518700   AI520380   AQ026260   AY232223   BF499749   BG638850   BG639286   BI231463   BI234171   BI632855   BI636086   BX057857   CA804636   CA804662   CK132884   CO153311   CO302898   CO322401   CO338147   EC063024   EC085993   EC261786   EC264358   EC266070
UniProtKB/Swiss-Prot	Q9XZ58
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0027053    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0027053 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages, during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0027053 expression level Developmental Stage   Expression Level embryo 00-02hr    5275 embryo 02-04hr    7061 embryo 04-06hr    3519 embryo 06-08hr    3121 embryo 08-10hr    3158 embryo 10-12hr    3112 embryo 12-14hr    2174 embryo 14-16hr    1620 embryo 16-18hr    1156 embryo 18-20hr    758 embryo 20-22hr    575 embryo 22-24hr    647 larva L1    1290 larva L2    1865 larva L3 12hr old    1526 larva L3 puffstage 1-2    1924 larva L3 puffstage 3-6    2298 larva L3 puffstage 7-9    2809 white prepupae new    3161 white prepupae 12hr    4248 white prepupae 24hr    4396 pupae 2d postWPP    3228 pupae 3d postWPP    1360 pupae 4d postWPP    953 adult male 01day    1233 adult male 05day    1513 adult male 30day    1359 adult female 01day    2342 adult female 05day    3800 adult female 30day    3960 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (5275) embryo 02-04hr  (7061) embryo 04-06hr  (3519) embryo 06-08hr  (3121) embryo 08-10hr  (3158) embryo 10-12hr  (3112) embryo 12-14hr  (2174) embryo 14-16hr  (1620) embryo 16-18hr  (1156) embryo 18-20hr  (758) embryo 20-22hr  (575) embryo 22-24hr  (647) larva L1  (1290) larva L2  (1865) larva L3 12hr old  (1526) larva L3 puffstage 1-2  (1924) larva L3 puffstage 3-6  (2298) larva L3 puffstage 7-9  (2809) white prepupae new  (3161) white prepupae 12hr  (4248) white prepupae 24hr  (4396) pupae 2d postWPP  (3228) pupae 3d postWPP  (1360) pupae 4d postWPP  (953) adult male 01day  (1233) adult male 05day  (1513) adult male 30day  (1359) adult female 01day  (2342) adult female 05day  (3800) adult female 30day  (3960) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (5275) embryo 02-04hr  (7061) embryo 04-06hr  (3519) embryo 06-08hr  (3121) embryo 08-10hr  (3158) embryo 10-12hr  (3112) embryo 12-14hr  (2174) embryo 14-16hr  (1620) embryo 16-18hr    1156 embryo 18-20hr    758 embryo 20-22hr    575 embryo 22-24hr    647 larva L1    1290 larva L2  (1865) larva L3 12hr old  (1526) larva L3 puffstage 1-2  (1924) larva L3 puffstage 3-6  (2298) larva L3 puffstage 7-9  (2809) white prepupae new  (3161) white prepupae 12hr  (4248) white prepupae 24hr  (4396) pupae 2d postWPP  (3228) pupae 3d postWPP    1360 pupae 4d postWPP    953 adult male 01day    1233 adult male 05day  (1513) adult male 30day    1359 adult female 01day  (2342) adult female 05day  (3800) adult female 30day  (3960) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    5275 embryo 02-04hr    7061 embryo 04-06hr    3519 embryo 06-08hr    3121 embryo 08-10hr    3158 embryo 10-12hr    3112 embryo 12-14hr    2174 embryo 14-16hr    1620 embryo 16-18hr    1156 embryo 18-20hr    758 embryo 20-22hr    575 embryo 22-24hr    647 larva L1    1290 larva L2    1865 larva L3 12hr old    1526 larva L3 puffstage 1-2    1924 larva L3 puffstage 3-6    2298 larva L3 puffstage 7-9    2809 white prepupae new    3161 white prepupae 12hr    4248 white prepupae 24hr    4396 pupae 2d postWPP    3228 pupae 3d postWPP    1360 pupae 4d postWPP    953 adult male 01day    1233 adult male 05day    1513 adult male 30day    1359 adult female 01day    2342 adult female 05day    3800 adult female 30day    3960 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    5275 embryo 02-04hr    7061 embryo 04-06hr    3519 embryo 06-08hr    3121 embryo 08-10hr    3158 embryo 10-12hr    3112 embryo 12-14hr    2174 embryo 14-16hr    1620 embryo 16-18hr    1156 embryo 18-20hr    758 embryo 20-22hr    575 embryo 22-24hr    647 larva L1    1290 larva L2    1865 larva L3 12hr old    1526 larva L3 puffstage 1-2    1924 larva L3 puffstage 3-6    2298 larva L3 puffstage 7-9    2809 white prepupae new    3161 white prepupae 12hr    4248 white prepupae 24hr    4396 pupae 2d postWPP    3228 pupae 3d postWPP    1360 pupae 4d postWPP    953 adult male 01day    1233 adult male 05day    1513 adult male 30day    1359 adult female 01day    2342 adult female 05day    3800 adult female 30day    3960 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0027053 expression level Developmental Stage   Expression Level embryo 00-02hr    5275 embryo 02-04hr    7061 embryo 04-06hr    3519 embryo 06-08hr    3121 embryo 08-10hr    3158 embryo 10-12hr    3112 embryo 12-14hr    2174 embryo 14-16hr    1620 embryo 16-18hr    1156 embryo 18-20hr    758 embryo 20-22hr    575 embryo 22-24hr    647 larva L1    1290 larva L2    1865 larva L3 12hr old    1526 larva L3 puffstage 1-2    1924 larva L3 puffstage 3-6    2298 larva L3 puffstage 7-9    2809 white prepupae new    3161 white prepupae 12hr    4248 white prepupae 24hr    4396 pupae 2d postWPP    3228 pupae 3d postWPP    1360 pupae 4d postWPP    953 adult male 01day    1233 adult male 05day    1513 adult male 30day    1359 adult female 01day    2342 adult female 05day    3800 adult female 30day    3960 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (5275) embryo 02-04hr  (7061) embryo 04-06hr  (3519) embryo 06-08hr  (3121) embryo 08-10hr  (3158) embryo 10-12hr  (3112) embryo 12-14hr  (2174) embryo 14-16hr  (1620) embryo 16-18hr  (1156) embryo 18-20hr  (758) embryo 20-22hr  (575) embryo 22-24hr  (647) larva L1  (1290) larva L2  (1865) larva L3 12hr old  (1526) larva L3 puffstage 1-2  (1924) larva L3 puffstage 3-6  (2298) larva L3 puffstage 7-9  (2809) white prepupae new  (3161) white prepupae 12hr  (4248) white prepupae 24hr  (4396) pupae 2d postWPP  (3228) pupae 3d postWPP  (1360) pupae 4d postWPP  (953) adult male 01day  (1233) adult male 05day  (1513) adult male 30day  (1359) adult female 01day  (2342) adult female 05day  (3800) adult female 30day  (3960) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (5275) embryo 02-04hr  (7061) embryo 04-06hr  (3519) embryo 06-08hr  (3121) embryo 08-10hr  (3158) embryo 10-12hr  (3112) embryo 12-14hr  2174 embryo 14-16hr  1620 embryo 16-18hr    1156 embryo 18-20hr    758 embryo 20-22hr    575 embryo 22-24hr    647 larva L1    1290 larva L2  1865 larva L3 12hr old  1526 larva L3 puffstage 1-2  1924 larva L3 puffstage 3-6  2298 larva L3 puffstage 7-9  (2809) white prepupae new  (3161) white prepupae 12hr  (4248) white prepupae 24hr  (4396) pupae 2d postWPP  (3228) pupae 3d postWPP    1360 pupae 4d postWPP    953 adult male 01day    1233 adult male 05day  1513 adult male 30day    1359 adult female 01day  2342 adult female 05day  (3800) adult female 30day  (3960) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    5275 embryo 02-04hr    7061 embryo 04-06hr    3519 embryo 06-08hr    3121 embryo 08-10hr    3158 embryo 10-12hr    3112 embryo 12-14hr    2174 embryo 14-16hr    1620 embryo 16-18hr    1156 embryo 18-20hr    758 embryo 20-22hr    575 embryo 22-24hr    647 larva L1    1290 larva L2    1865 larva L3 12hr old    1526 larva L3 puffstage 1-2    1924 larva L3 puffstage 3-6    2298 larva L3 puffstage 7-9    2809 white prepupae new    3161 white prepupae 12hr    4248 white prepupae 24hr    4396 pupae 2d postWPP    3228 pupae 3d postWPP    1360 pupae 4d postWPP    953 adult male 01day    1233 adult male 05day    1513 adult male 30day    1359 adult female 01day    2342 adult female 05day    3800 adult female 30day    3960 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    5275 embryo 02-04hr    7061 embryo 04-06hr    3519 embryo 06-08hr    3121 embryo 08-10hr    3158 embryo 10-12hr    3112 embryo 12-14hr    2174 embryo 14-16hr    1620 embryo 16-18hr    1156 embryo 18-20hr    758 embryo 20-22hr    575 embryo 22-24hr    647 larva L1    1290 larva L2    1865 larva L3 12hr old    1526 larva L3 puffstage 1-2    1924 larva L3 puffstage 3-6    2298 larva L3 puffstage 7-9    2809 white prepupae new    3161 white prepupae 12hr    4248 white prepupae 24hr    4396 pupae 2d postWPP    3228 pupae 3d postWPP    1360 pupae 4d postWPP    953 adult male 01day    1233 adult male 05day    1513 adult male 30day    1359 adult female 01day    2342 adult female 05day    3800 adult female 30day    3960 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0027053    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0027053 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0027053 expression level Tissue   Expression Level Larval Central Nervous System    467.625 Larval Midgut    198.5 Larval Hindgut    197.2 Larval Malpighian Tubules    338.3 Larval Fat Body    329.3 Larval Salivary Gland    314.7 Larval Trachea    373.325 Larval Carcass    258.9 Adult Head    127.9 Adult Eye    188.75 Adult Brain    134.3 Adult Thoracic-Abdominal Ganglion    137.8 Adult Crop    155.3 Adult Midgut    191.8 Adult Hindgut    140.4 Adult Malpighian Tubules    183.8 Adult Fat Body    167.3 Adult Salivary Gland    173.7 Adult Heart    167.975 Adult VirginFemale Spermatheca    203.3 Adult InseminatedFemale Spermatheca    190.7 Adult Ovary    395.3 Adult Testis    176.5 Adult Male Accessory Gland    243.3 Adult Carcass    127.6 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    467.625 Larval Midgut    198.5 Larval Hindgut    197.2 Larval Malpighian Tubules    338.3 Larval Fat Body    329.3 Larval Salivary Gland    314.7 Larval Trachea    373.325 Larval Carcass    258.9 Adult Head    127.9 Adult Eye    188.75 Adult Brain    134.3 Adult Thoracic-Abdominal Ganglion    137.8 Adult Crop    155.3 Adult Midgut    191.8 Adult Hindgut    140.4 Adult Malpighian Tubules    183.8 Adult Fat Body    167.3 Adult Salivary Gland    173.7 Adult Heart    167.975 Adult VirginFemale Spermatheca    203.3 Adult InseminatedFemale Spermatheca    190.7 Adult Ovary    395.3 Adult Testis    176.5 Adult Male Accessory Gland    243.3 Adult Carcass    127.6 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    467.625 Larval Midgut    198.5 Larval Hindgut    197.2 Larval Malpighian Tubules    338.3 Larval Fat Body    329.3 Larval Salivary Gland    314.7 Larval Trachea    373.325 Larval Carcass    258.9 Adult Head    127.9 Adult Eye    188.75 Adult Brain    134.3 Adult Thoracic-Abdominal Ganglion    137.8 Adult Crop    155.3 Adult Midgut    191.8 Adult Hindgut    140.4 Adult Malpighian Tubules    183.8 Adult Fat Body    167.3 Adult Salivary Gland    173.7 Adult Heart    167.975 Adult VirginFemale Spermatheca    203.3 Adult InseminatedFemale Spermatheca    190.7 Adult Ovary    395.3 Adult Testis    176.5 Adult Male Accessory Gland    243.3 Adult Carcass    127.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    467.625 Larval Midgut    198.5 Larval Hindgut    197.2 Larval Malpighian Tubules    338.3 Larval Fat Body    329.3 Larval Salivary Gland    314.7 Larval Trachea    373.325 Larval Carcass    258.9 Adult Head    127.9 Adult Eye    188.75 Adult Brain    134.3 Adult Thoracic-Abdominal Ganglion    137.8 Adult Crop    155.3 Adult Midgut    191.8 Adult Hindgut    140.4 Adult Malpighian Tubules    183.8 Adult Fat Body    167.3 Adult Salivary Gland    173.7 Adult Heart    167.975 Adult VirginFemale Spermatheca    203.3 Adult InseminatedFemale Spermatheca    190.7 Adult Ovary    395.3 Adult Testis    176.5 Adult Male Accessory Gland    243.3 Adult Carcass    127.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0027053 expression level Tissue   Expression Level Larval Central Nervous System    467.625 Larval Midgut    198.5 Larval Hindgut    197.2 Larval Malpighian Tubules    338.3 Larval Fat Body    329.3 Larval Salivary Gland    314.7 Larval Trachea    373.325 Larval Carcass    258.9 Adult Head    127.9 Adult Eye    188.75 Adult Brain    134.3 Adult Thoracic-Abdominal Ganglion    137.8 Adult Crop    155.3 Adult Midgut    191.8 Adult Hindgut    140.4 Adult Malpighian Tubules    183.8 Adult Fat Body    167.3 Adult Salivary Gland    173.7 Adult Heart    167.975 Adult VirginFemale Spermatheca    203.3 Adult InseminatedFemale Spermatheca    190.7 Adult Ovary    395.3 Adult Testis    176.5 Adult Male Accessory Gland    243.3 Adult Carcass    127.6 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    467.625 Larval Midgut    198.5 Larval Hindgut    197.2 Larval Malpighian Tubules    338.3 Larval Fat Body    329.3 Larval Salivary Gland    314.7 Larval Trachea    373.325 Larval Carcass    258.9 Adult Head    127.9 Adult Eye    188.75 Adult Brain    134.3 Adult Thoracic-Abdominal Ganglion    137.8 Adult Crop    155.3 Adult Midgut    191.8 Adult Hindgut    140.4 Adult Malpighian Tubules    183.8 Adult Fat Body    167.3 Adult Salivary Gland    173.7 Adult Heart    167.975 Adult VirginFemale Spermatheca    203.3 Adult InseminatedFemale Spermatheca    190.7 Adult Ovary    395.3 Adult Testis    176.5 Adult Male Accessory Gland    243.3 Adult Carcass    127.6 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    467.625 Larval Midgut    198.5 Larval Hindgut    197.2 Larval Malpighian Tubules    338.3 Larval Fat Body    329.3 Larval Salivary Gland    314.7 Larval Trachea    373.325 Larval Carcass    258.9 Adult Head    127.9 Adult Eye    188.75 Adult Brain    134.3 Adult Thoracic-Abdominal Ganglion    137.8 Adult Crop    155.3 Adult Midgut    191.8 Adult Hindgut    140.4 Adult Malpighian Tubules    183.8 Adult Fat Body    167.3 Adult Salivary Gland    173.7 Adult Heart    167.975 Adult VirginFemale Spermatheca    203.3 Adult InseminatedFemale Spermatheca    190.7 Adult Ovary    395.3 Adult Testis    176.5 Adult Male Accessory Gland    243.3 Adult Carcass    127.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    467.625 Larval Midgut    198.5 Larval Hindgut    197.2 Larval Malpighian Tubules    338.3 Larval Fat Body    329.3 Larval Salivary Gland    314.7 Larval Trachea    373.325 Larval Carcass    258.9 Adult Head    127.9 Adult Eye    188.75 Adult Brain    134.3 Adult Thoracic-Abdominal Ganglion    137.8 Adult Crop    155.3 Adult Midgut    191.8 Adult Hindgut    140.4 Adult Malpighian Tubules    183.8 Adult Fat Body    167.3 Adult Salivary Gland    173.7 Adult Heart    167.975 Adult VirginFemale Spermatheca    203.3 Adult InseminatedFemale Spermatheca    190.7 Adult Ovary    395.3 Adult Testis    176.5 Adult Male Accessory Gland    243.3 Adult Carcass    127.6 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    127.9   NA  Eye    188.75   NA  Brain    134.3   467.625  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    137.8   NA  Crop    155.3   198.5  Midgut    191.8   197.2  Hindgut    140.4   338.3  Malpighian Tubules    183.8   329.3  Fat Body    167.3   314.7  Salivary Gland    173.7   NA  Heart    167.975   373.325  Trachea    NA   NA  VirginFemale Spermatheca    203.3   NA  InseminatedFemale Spermatheca    190.7   NA  Ovary    395.3   NA  Testis    176.5   NA  Male Accessory Gland    243.3   258.9  Carcass    127.6 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_06
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0027053 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG14884-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal CSN5N lethal | adult stage (with CSN5quo-2) CSN5quo-3 lethal | adult stage (with CSN5quo-3) CSN5quo-2 lethal | larval stage CSN5N lethal | larval stage | recessive CSN5null lethal | pupal stage (with CSN5null) CSN5quo-1 lethal | pupal stage (with CSN5quo-1) CSN5null lethal | pupal stage | recessive CSN5quo-1 CSN5quo-2 CSN5quo-3 lethal | recessive CSN52 CSN53 CSN5ex9 CSN5ex35 CSN5L4032 CSN5M203 CSN5M233 CSN5M255 CSN5null CSN5quo-1 CSN5quo-2 CSN5quo-3 lethal | recessive | heat sensitive CSN5L4032 lethal | second instar larval stage (with CSN5null) CSN5quo-2 lethal | second instar larval stage (with CSN5quo-2) CSN5null semi-lethal (with CSN5null) CSN5quo-3 semi-lethal (with CSN5quo-3) CSN5null viable CSN5ex15 CSN5ex27 viable (with CSN5ex21) CSN5L4032 viable (with CSN5L4032) CSN5ex21 Sterility Allele female sterile | germline clone | recessive CSN5null female sterile germline-dependent | germline clone CSN5N Other Phenotypes Allele chemical sensitive | larval stage CSN5null developmental rate defective CSN5null size defective (with CSN5null) CSN5quo-3 size defective (with CSN5quo-3) CSN5null visible | somatic clone CSN5null wild-type CSN5T:Hsap\MYC Phenotype manifest in Allele chorion | germline clone CSN5L4032 cystocyte | germline clone CSN5N dorsal appendage (with CSN5ex21) CSN5L4032 dorsal appendage (with CSN5L4032) CSN5ex21 dorsal appendage | germline clone CSN5L4032 CSN5N egg | germline clone CSN5L4032 CSN5N embryonic/larval optic neuropil CSN5quo-2 eye | somatic clone CSN5null female germline stem cell | germline clone CSN5N germarium CSN5L4032 lamina anlage glial cell CSN5quo-1 lamina anlage glial cell | somatic clone CSN5quo-1 larva CSN52 CSN53 CSN5L4032 melanotic mass CSN5null nurse cell (with CSN5ex13) CSN5L4032 nurse cell (with CSN5ex21) CSN5L4032 nurse cell (with CSN5L4032) CSN5ex13 CSN5ex21 nurse cell fusome | germline clone CSN5N nurse cell spectrosome | germline clone CSN5L4032 CSN5N ovary CSN5quo-2 ovary | germline clone CSN5null CSN5quo-1 photoreceptor cell R1 & axon | somatic clone CSN5quo-1 photoreceptor cell R2 & axon CSN5quo-1 photoreceptor cell R2 & axon (with Df(3R)RK6-3) CSN5quo-1 photoreceptor cell R2 & axon | somatic clone CSN5quo-1 photoreceptor cell R3 & axon CSN5quo-1 photoreceptor cell R3 & axon (with Df(3R)RK6-3) CSN5quo-1 photoreceptor cell R3 & axon | somatic clone CSN5quo-1 photoreceptor cell R4 & axon CSN5quo-1 photoreceptor cell R4 & axon (with Df(3R)RK6-3) CSN5quo-1 photoreceptor cell R4 & axon | somatic clone CSN5quo-1 photoreceptor cell R5 & axon CSN5quo-1 photoreceptor cell R5 & axon (with Df(3R)RK6-3) CSN5quo-1 photoreceptor cell R5 & axon | somatic clone CSN5quo-1 photoreceptor cell R6 & axon | somatic clone CSN5quo-1 pole cell | germline clone CSN5L4032 pupa CSN52 CSN53 CSN5L4032 trichogen cell | somatic clone | supernumerary CSN5null wing (with CSN5null) CSN5quo-3 wing (with CSN5quo-3) CSN5null wing vein | ectopic | somatic clone CSN5null
Classical Alleles ( 19 )
For All Classical Alleles Show
Allele of CSN5 Class Mutagen Stocks Known lesion CSN5L4032 P-element activity 2 Yes CSN52 PM hybrid dysgenesis 0 -- CSN53 PM hybrid dysgenesis 0 -- CSN5ex13 Delta2-3 0 Yes CSN5ex15 Delta2-3 0 Yes CSN5ex21 Delta2-3 0 Yes CSN5ex27 Delta2-3 0 Yes CSN5ex35 Delta2-3 0 Yes CSN5ex9 Delta2-3 0 Yes CSN5M203 ethyl methanesulfonate 0 -- CSN5M233 ethyl methanesulfonate 0 -- CSN5M255 ethyl methanesulfonate 0 -- CSN5N loss of function allele P-element activity 0 Yes CSN5null P-element activity 0 Yes CSN5quo-1 loss of function allele ethyl methanesulfonate 0 Yes CSN5quo-2 ethyl methanesulfonate 0 Yes CSN5quo-3 ethyl methanesulfonate 0 Yes CSN5quo3 0 -- CSN5unspecified 0 --
Alleles Carried on Transgenic Constructs ( 13 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CSN5 Class Mutagen Stocks Known lesion CSN5JF03159 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CSN5+t30 in vitro construct - genomic fragment 0 Yes CSN5+t6.6 in vitro construct - genomic fragment 0 Yes CSN5+tSa in vitro construct - genomic fragment 0 Yes CSN5D148N.hs in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes CSN5D148N.Scer\UAS in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes CSN5dsRNA.cPa in vitro construct - RNAi 0 Yes CSN5GD5708 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes CSN5hs.PS in vitro construct - regulatory fusion 0 Yes CSN5NIG.14884R in vitro construct - RNAi 0 Yes CSN5Scer\UAS.cSa in vitro construct - regulatory fusion 0 Yes CSN5Scer\UAS.cWa in vitro construct - regulatory fusion 0 Yes CSN5T:Hsap\MYC in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)bxd100 (Spradling et al., 1999, Freilich et al., 1999, BDGP Project Members, 1994-1999) Df(3R)Exel6269 (Ryder, 2004.4.26) Df(3R)Exel7330 (Ryder, 2004.4.26) Df(3R)P10 (Sanchez-Herrero, 1996.3.7) Df(3R)P115 (Sanchez-Herrero, 1996.3.7) Df(3R)RK6-3 (Suh et al., 2002)
Not disrupted in	Df(3R)C4 (Sanchez-Herrero, 1996.3.7) Df(3R)P9 (Sanchez-Herrero, 1996.3.7) Df(3R)sbd104 (Suh et al., 2002) Df(3R)Ubx109 (Sanchez-Herrero, 1996.3.7)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD5708} NA P{TRiP.JF03159} NA P{UAS-CSN5.D148N} NA P{UAS-CSN5.S} NA P{UAS-CSN5.W} NA heat-shock construct P{hs-csn5.D148N} NA P{hs-CSN5.S} NA characterization construct P{CSN5.genomic.T:Hsap\MYC} NA P{CSN5.genomic} NA P{CSN5+t6.6} NA P{CSN5+tSa} NA P{NIG.14884R} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}CSN5L4032 No
Gene Ontology: Function, Process & Cellular Component ( 16 unique terms )
Terms Based on Experimental Evidence ( 15 terms )
Molecular Function
CV term Evidence References
NEDD8 activating enzyme activity inferred from mutant phenotype (assigned by UniProtKB) (Doronkin et al., 2003) protein binding inferred from physical interaction with alien (Freilich et al., 1999) inferred from physical interaction with UniProtKB:Q7KRW1 (assigned by UniProtKB) (Gemmill et al., 2002)
Biological Process
CV term Evidence References
axonogenesis inferred from mutant phenotype (Suh et al., 2002) compound eye photoreceptor cell differentiation inferred from mutant phenotype (Suh et al., 2002) glial cell migration inferred from mutant phenotype (Suh et al., 2002) mitotic cell cycle G2/M transition DNA damage checkpoint inferred from genetic interaction with nbs (Kondo and Perrimon, 2011) multicellular organismal development inferred from mutant phenotype (Freilich et al., 1999) negative regulation of proteasomal ubiquitin-dependent protein catabolic process inferred from mutant phenotype (Ullah et al., 2007) oocyte anterior/posterior axis specification inferred from mutant phenotype (Doronkin et al., 2002) oocyte dorsal/ventral axis specification inferred from mutant phenotype (Doronkin et al., 2002) positive regulation of cell cycle inferred from mutant phenotype (Ullah et al., 2007) protein deneddylation inferred from mutant phenotype (assigned by UniProtKB) (Doronkin et al., 2003) protein stabilization inferred from mutant phenotype (Ullah et al., 2007)
Cellular Component
CV term Evidence References
cytoplasm inferred from direct assay (Suh et al., 2002) signalosome inferred from direct assay (Freilich et al., 1999) inferred from mutant phenotype (assigned by UniProtKB) (Doronkin et al., 2003)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
compound eye photoreceptor cell differentiation traceable author statement (Ou et al., 2003) oogenesis traceable author statement (Wei and Deng, 2003)
Cellular Component
CV term Evidence References
signalosome inferred from sequence or structural similarity (Freilich, 1999.2.17) inferred from sequence or structural similarity with TAIR:gene:2017764; AGI_LocusCode:At1g22920 AND traceable author statement (Suh et al., 2002) non-traceable author statement (Wei and Deng, 2003)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CSN5 allele Gene References CSN5ex9 grk (Doronkin et al., 2002) CSN5ex15 grk (Doronkin et al., 2002) CSN5ex21 mei-41 (Doronkin et al., 2002) CSN5ex35 grk (Doronkin et al., 2002) CSN5L4032 CSN4 (Doronkin et al., 2003) Egfr (Doronkin et al., 2002) grk (Doronkin et al., 2002) mei-41 (Doronkin et al., 2002) Rpn6 (Doronkin et al., 2003) trn (Doronkin et al., 2003) CSN5quo-1 ago (Doronkin et al., 2003) CSN5unspecified lin19 (Doronkin et al., 2003) unspecified slmb (Muzzopappa and Wappner, 2005)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 67045 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0027053 DroID - A comprehensive database of gene and protein interactions. • FBgn0027053 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42000
Orthologs
Genome-wide drosophilid orthologs	Dana\GF18500 Dere\GG17007 Dgri\GH19288 Dmoj\GI23503 Dper\GL22178 Dpse\GA13321 Dsec\GM15160 Dsim\GD19103 Dvir\GJ10255 Dwil\GK14483 Dyak\CSN5
Curated drosophilid orthologs	Dpse\GA13321   Dyak\CSN5
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL001058-PA Aedes aegypti (mosquito) AAEL014747-PA Aedes aegypti (mosquito) AGAP002880-PA Anopheles gambiae (mosquito) XP_623836.1 Apis mellifera (honey bee) XP_001950285.1 Acyrthosiphon pisum (pea aphid) At1g71230.1 Arabidopsis thaliana (wall cress) 15731 Batrachochytrium dendrobatidis (chytrid fungus) 124400 Branchiostoma floridae (lancelet) BGIBMGA002790-PA Bombyx mori (silk worm) ENSBTAP00000003609 Bos taurus (bovine) CN28389 Caenorhabditis brenneri (small nematode) CN30409 Caenorhabditis brenneri (small nematode) CBP04657 Caenorhabditis briggsae (nematode) CE06722 Caenorhabditis elegans (worm) ENSCAFP00000010982 Canis familiaris (dog) CAGL0G05676g Candida glabrata (haploid yeast) ENSCINP00000013258 Ciona intestinalis (sea squirt) JA17956 Caenorhabditis japonica (nematode) cn10113 Cryptococcus neoformans (yeast-like fungus) CPIJ012314 Culex pipens (mosquito) ENSCPOP00000010608 Cavia porcellus (guinea pig) 130343 Chlamidomonas reinhardtii (green alga) RP14950 Caenorhabditis remanei (nematode) ENSCSAVP00000010539 Ciona savignyi (sedentary tunicate) 163387 Capitella spl (polychaete worm) DDB0233103 Dictyostelium discoideum (amoeba) DEHA2F03498g Debaryomyces Hansenii (yeast) 109433 Daphnia pulex (daphnia) ENSDARP00000074782 Danio rerio (zebra fish) ENSECAP00000011800 Equus caballus (horse) XP_656573 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000003803 Gymnopilus aculeatus (mushroom) ENSGALP00000023379 Gallus gallus (chicken) 185158 Hypsipyla robusta (cedar shoot borer) ENSP00000350512 Homo sapiens (human) ISCW019527-PA Ixodes scapularis (deer tick) 224262 Lottia gigantea (owl limpet) LmjF16.0850 Leishmania major (virus) 19880 Monocosta brevicollis (choanoflagellate) ENSMODP00000009744 Monodelphis domestica (gray opossum) ENSMMUP00000008263 Macaca mulatta (rhesus monkey) ENSMUSP00000027050 Mus musculus (house mouse) 182399 Nematostella vectensis (starlet anemone) XP_001599567.1 Nasonia vitripennis (wasp) ENSOANP00000003677 Ornithorynchus anatinus (platypus) ENSORLP00000010536 Oryzias latipes (japanese killifish) LOC_Os04g56070.1 Oryza sativa (asian rice) 8466 Ostreococcus tauri (green alga) PHUM002680-PA Pediculus humanus (human body louse) PP10450 Pristionchus pacificus (nematode) 174024 Physcomitrella patens (moss) 192990 Physcomitrella patens (moss) ENSPPYP00000020922 Pongo pygmaeus (orangutan) 95992 Phytophthora ramorum (sudden oak death pathogen) 134808 Phytophthora sojae (root rot pathogen) 737517 Populus trichocarpa (black cottonwood) ENSPTRP00000043693 Pan troglodytes (chimpanzee) ENSRNOP00000008877 Rattus norvegicus (norway rat) 145540 Sorghum bicolor (sorghum) Smp_131660 Schistosoma mansoni (trematode parasite) SPAC1687.13c Schizosaccharomyces pombe (fission yeast) XP_001190460.1 Strongylocentrotus purpuratus (purple sea urchin) XP_001200311.1 Strongylocentrotus purpuratus (purple sea urchin) 27810 Trichoplax adhaerens (metazoa) XP_972769.1 Tribolium castaneum (red flour beetle) Tc00.1047053507083.60 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053509901.140 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000013006 Tetraodon nigroviridis (green spotted pufferfish) 264451 Thalassiosira pseudonana (marine diatom) ENSTRUP00000023720 Takifugu rubripes (pufferfish Takifugu) 3761.m00260 Tetrahymena thermophila (ciliate protozoa) 96647.m00094 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000050270 Xenopus tropicalis (frog) YALI0E04829g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB11257 NV19042 LH15176 ISCW019527 FBgn0068181 FBgn0216489 FBgn0197541 FBgn0190610 FBgn0170080 JGI_V11_109433 FBgn0073358 FBgn0159770 FBgn0146229 FBgn0126754 FBgn0109235 FBgn0095518 CPIJ012314 BGIBMGA002790 ACYPI006786 GB12145 AGAP002880 AAEL014747 AAEL001058 PHUM016420 GLEAN_11816
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
Bloomington	28732 y1 v1; P{TRiP.JF03159}attP2 10301 y1 w1118; P{lacW}CSN5L4032/TM3, Ser1
Kyoto	111044 yd2 w1118 P{ey-FLP.N}2 P{GMR-lacZ.C(38.1)}TPN1; P{neoFRT}82B P{lacW}CSN5L4032/TM6B, P{Car20y}TPN1, Tb1
Genomic Clones ( 1 )
	BACR01H23 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 31 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD14392
Other clones	DPiM_LD14392 yak-ad_CSN5
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT14388 GH20811 LD19430 LD27982 LD33883 LD35626 LD36980 LD37813 LD37964 LD38384 LD40523 LD41962 RE21934 RE29827 SD17654 SD26745
Other clones	61763 62483 522275 562146 570000 EK185119 EK188047 EN01721 EN16040 ESG0114c.B21_C09 ESG0114c.B21_G09 LP02439
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0027053 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42000
Antibody Information
	polyclonal (Freilich et al., 1999)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: CH5 l(3)L4032 (Freilich et al., 1999) Source for merge of: CSN5 l(3)89Cf (Doronkin et al., 2003)
Additional comments
Other Comments
	S2 cells are treated with dsRNA made from templates generated with primers directed against this gene to assess effect on degradation of dup and geminin genes. (Higa et al., 2003) Homozygous mutant clones in the female germline disrupt both the dorsoventral and anterioposterior axes of the oocyte as a result of decreased grk protein. (Doronkin et al., 2002) CSN5 is required in R cells to induce lamina glial cell migration. (Suh et al., 2002) COP9 signalosome is essential for development. (Freilich et al., 1999)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_058094 RefSeq (Proteins) • NP_477442 DDBJ / EMBL / GenBank • AA439751 AAD27862 AAD28608 AAF55321 AC011615 AF129083 AF132563 AQ026260 Entrez Gene - A searchable database of RefSeq genes. • 42000 UniProtKB/Swiss-Prot • Q9XZ58
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Mov34/MPN/PAD-1 (IPR000555)
Linkouts
	BioGRID - A database of protein and genetic interactions • 67045 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0027053 DroID - A comprehensive database of gene and protein interactions. • FBgn0027053 DRSC - Results from RNAi screens. • FBgn0027053 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0027053 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG14884-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0027053 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42000 InParanoid A subset of ortholog calls from InParanoid. • AAEL001058-PA Aedes aegypti (mosquito) AAEL014747-PA Aedes aegypti (mosquito) AGAP002880-PA Anopheles gambiae (mosquito) XP_623836.1 Apis mellifera (honey bee) XP_001950285.1 Acyrthosiphon pisum (pea aphid) At1g71230.1 Arabidopsis thaliana (wall cress) 15731 Batrachochytrium dendrobatidis (chytrid fungus) 124400 Branchiostoma floridae (lancelet) BGIBMGA002790-PA Bombyx mori (silk worm) ENSBTAP00000003609 Bos taurus (bovine) CN28389 Caenorhabditis brenneri (small nematode) CN30409 Caenorhabditis brenneri (small nematode) CBP04657 Caenorhabditis briggsae (nematode) CE06722 Caenorhabditis elegans (worm) ENSCAFP00000010982 Canis familiaris (dog) CAGL0G05676g Candida glabrata (haploid yeast) ENSCINP00000013258 Ciona intestinalis (sea squirt) JA17956 Caenorhabditis japonica (nematode) cn10113 Cryptococcus neoformans (yeast-like fungus) CPIJ012314 Culex pipens (mosquito) ENSCPOP00000010608 Cavia porcellus (guinea pig) 130343 Chlamidomonas reinhardtii (green alga) RP14950 Caenorhabditis remanei (nematode) ENSCSAVP00000010539 Ciona savignyi (sedentary tunicate) 163387 Capitella spl (polychaete worm) DDB0233103 Dictyostelium discoideum (amoeba) DEHA2F03498g Debaryomyces Hansenii (yeast) 109433 Daphnia pulex (daphnia) ENSDARP00000074782 Danio rerio (zebra fish) ENSECAP00000011800 Equus caballus (horse) XP_656573 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000003803 Gymnopilus aculeatus (mushroom) ENSGALP00000023379 Gallus gallus (chicken) 185158 Hypsipyla robusta (cedar shoot borer) ENSP00000350512 Homo sapiens (human) ISCW019527-PA Ixodes scapularis (deer tick) 224262 Lottia gigantea (owl limpet) LmjF16.0850 Leishmania major (virus) 19880 Monocosta brevicollis (choanoflagellate) ENSMODP00000009744 Monodelphis domestica (gray opossum) ENSMMUP00000008263 Macaca mulatta (rhesus monkey) ENSMUSP00000027050 Mus musculus (house mouse) 182399 Nematostella vectensis (starlet anemone) XP_001599567.1 Nasonia vitripennis (wasp) ENSOANP00000003677 Ornithorynchus anatinus (platypus) ENSORLP00000010536 Oryzias latipes (japanese killifish) LOC_Os04g56070.1 Oryza sativa (asian rice) 8466 Ostreococcus tauri (green alga) PHUM002680-PA Pediculus humanus (human body louse) PP10450 Pristionchus pacificus (nematode) 174024 Physcomitrella patens (moss) 192990 Physcomitrella patens (moss) ENSPPYP00000020922 Pongo pygmaeus (orangutan) 95992 Phytophthora ramorum (sudden oak death pathogen) 134808 Phytophthora sojae (root rot pathogen) 737517 Populus trichocarpa (black cottonwood) ENSPTRP00000043693 Pan troglodytes (chimpanzee) ENSRNOP00000008877 Rattus norvegicus (norway rat) 145540 Sorghum bicolor (sorghum) Smp_131660 Schistosoma mansoni (trematode parasite) SPAC1687.13c Schizosaccharomyces pombe (fission yeast) XP_001190460.1 Strongylocentrotus purpuratus (purple sea urchin) XP_001200311.1 Strongylocentrotus purpuratus (purple sea urchin) 27810 Trichoplax adhaerens (metazoa) XP_972769.1 Tribolium castaneum (red flour beetle) Tc00.1047053507083.60 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053509901.140 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000013006 Tetraodon nigroviridis (green spotted pufferfish) 264451 Thalassiosira pseudonana (marine diatom) ENSTRUP00000023720 Takifugu rubripes (pufferfish Takifugu) 3761.m00260 Tetrahymena thermophila (ciliate protozoa) 96647.m00094 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000050270 Xenopus tropicalis (frog) YALI0E04829g Yarrowia lipolytica (nonconventional yeast) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /dbzhnsky/csn5-1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42000 modMine - Data generated by the modENCODE project. • FBgn0027053 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB11257 NV19042 LH15176 ISCW019527 FBgn0068181 FBgn0216489 FBgn0197541 FBgn0190610 FBgn0170080 JGI_V11_109433 FBgn0073358 FBgn0159770 FBgn0146229 FBgn0126754 FBgn0109235 FBgn0095518 CPIJ012314 BGIBMGA002790 ACYPI006786 GB12145 AGAP002880 AAEL014747 AAEL001058 PHUM016420 GLEAN_11816
Synonyms & Secondary IDs ( 24 )
Reported As
Symbol Synonym	BcDNA:LD14392   BcDNA.LD14392 (Tsang, 1999.3.2) CG14884 (Perkins et al., 2009, Gandhi et al., 2007) CH5   CSN5 (Gemmill et al., 2005, Buckley et al., 2007, Buckley et al., 2006, Oren-Giladi et al., 2008, Mummery-Widmer et al., 2009, White et al., 2011, Wu et al., 2005, Ullah et al., 2007, Higa et al., 2006, Chan et al., 2008, Knowles et al., 2009, Chan et al., 2008, Dworkin et al., 2009, Djagaeva and Doronkin, 2009, Rencus-Lazar et al., 2008, Broemer et al., 2010, Kondo and Perrimon, 2011, Kim et al., 2010) csn5 (Oron et al., 2005, Harari-Steinberg et al., 2005, Park et al., 2004, Wei and Deng, 2003, Oron et al., 2002, Oren-Giladi et al., 2008, Harari-Steinberg et al., 2007, Ullah et al., 2007, Rencus-Lazar et al., 2008) Csn5 (Oron et al., 2001, Cope et al., 2002, Ullah et al., 2007) CSN-5 (Gemmill et al., 2002) Dch5 (Wei and Deng, 2003, Freilich et al., 1999) DCH5 (Segal et al., 2000, Freilich, 1999.2.17, Segal et al., 1999, ) dch5 (Freilich et al., 1999) Jab1 (Doronkin et al., 2001, Cope et al., 2002) JAB1 (Gemmill et al., 2002) jab1/csn5 (Chotard and Salecker, 2004, Tayler and Garrity, 2003) JAB1/CSN5 (Suh et al., 2002) JadBp (Spradling et al., 1999) l(3)89Cf (Sanchez-Herrero, 1996.3.7, ) l(3)L4032 (Beaton, 2000.1.31, BDGP Project Members, 1994-1999, ) l(3)M203 (Sanchez-Herrero, 1998.8.30) quo (Suh et al., 2002)
Name Synonym	COP9 complex homolog subunit 5 (Freilich, 1999.2.17, ) Drosophila COP9 signalosome homolog 5 (Freilich et al., 1999) Jun activation domain binding protein (Spradling et al., 1999) JUN activation domain-binding protein-1 (Doronkin et al., 2001)
Secondary FlyBase IDs
	FBgn0016027 FBgn0024551
References ( 68 )
Generate a list of	All references relating to this gene ( 68 )
List References by type	Research paper  ( 30 ) Supplementary material  ( 5 ) Review  ( 7 ) Personal communication to FlyBase  ( 5 ) Abstract  ( 12 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 2 ) Computer file  ( 2 ) Curated genome annotation  ( 1 ) Automatic genome annotation  ( 1 ) Stock list  ( 1 )
Recent research papers ( 4 )
	Kondo and Perrimon, 2011, Sci. Signal. 4(154): rs1 A Genome-Wide RNAi Screen Identifies Core Components of the G2-M DNA Damage Checkpoint. [FBrf0212700] White et al., 2011, J. Cell Biol. 193(4): 677--694 Drosophila histone locus bodies form by hierarchical recruitment of components. [FBrf0213662] Broemer et al., 2010, Mol. Cell 40(5): 810--822 Systematic In Vivo RNAi Analysis Identifies IAPs as NEDD8-E3 Ligases. [FBrf0212528] Kim et al., 2010, Dev. Biol. 346(2): 247--257 Drosophila Cand1 regulates Cullin3-dependent E3 ligases by affecting the neddylation of Cullin3 and by controlling the stability of Cullin3 and adaptor protein. [FBrf0211875] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...