DCH5, l(3)L4032, COP9 complex homolog subunit 5, l(3)89Cf, jab1/csn5
Gene model reviewed during 5.47
None of the polypeptides share 100% sequence identity.
Component of the CSN complex, probably composed of CSN1b, alien/CSN2, CSN3, CSN4, CSN5, CSN6, CSN7 and CSN8. Interacts directly with CSN2. Also exists as monomeric form. Interacts via its MPN domain with Trc8.
The JAMM motif is essential for the protease activity of the CSN complex resulting in deneddylation of cullins. It constitutes the catalytic center of the complex (By similarity).
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CSN5 using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\CSN5 in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Homozygous mutant clones in the female germline disrupt both the dorsoventral and anterioposterior axes of the oocyte as a result of decreased grk protein.
COP9 signalosome is essential for development.