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Gene Dmel\Aats-tyr

General Information
Symbol	Dmel\Aats-tyr	Species	D. melanogaster
Name	Tyrosyl-tRNA synthetase	Annotation symbol	CG4561
Feature type	protein_coding_gene	FlyBase ID	FBgn0027080
Gene Model Status	Current	Stock availability	2 publicly available
Also Known As	TyrRS, dYARS
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	72F1-72F1	Sequence location	3L:16,410,449..16,412,402 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Tyrosyl-tRNA synthetase is referred to in FlyBase by the symbol Dmel\Aats-tyr (CG4561, FBgn0027080). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: tyrosine-tRNA ligase activity. It is reported to be involved in the biological process: tyrosyl-tRNA aminoacylation. 9 alleles are reported. The phenotypes of these alleles are annotated with: giant fiber neuron; scutellar bristle. It has one annotated transcript and one annotated polypeptide. Protein features are: Aminoacyl-tRNA synthetase, class Ic; Nucleic acid-binding, OB-fold; Rossmann-like alpha/beta/alpha sandwich fold; Tyrosine-tRNA ligase; Tyrosine-tRNA ligase, archaeal/eukaryotic-type; tRNA-binding domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed at stages throughout embryogenesis, during early larval stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1632234_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Aats-tyr. Gene sequence location is 3L:16410449..16412402.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 72F1-72F1   Limits computationally determined from genome sequence between P{lacW}l(3)s3123s3123 and P{lacW}l(3)j10E8j10E8&P{PZ}l(3)1053210532
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Aats-tyr for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.43 Gene model reviewed during 5.44
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Aats-tyr-RA FBtr0075410  NM_140638   1771   525
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Aats-tyr-PA   FBpp0075168   58.2   525   6.86     NP_648895   AAF49462
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Aminoacyl-tRNA synthetase, class Ic (IPR002305) Tyrosine-tRNA ligase (IPR002307) tRNA-binding domain (IPR002547) Nucleic acid-binding, OB-fold (IPR012340) Tyrosine-tRNA ligase, archaeal/eukaryotic-type (IPR023617) Rossmann-like alpha/beta/alpha sandwich fold (IPR014729)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA264169   AA392520   AA392750   AA696144   AA697091   AA735326   AA802954   AA803946   AA821032   AA941825   AA941897   AE014296 AAF49462   AF083316   AI063662   AI257542   AI388949   AI402508   AI455095   AI456249   AI512019   AI518188   AI518442   AI518666   AI519977   AI520432   AI534037   AI534221   AI542238   AY051662 AAK93086   BF497787   BF502792   BF502880   BF505317   BG635425   BG635727   BG635900   BG640603   BG641406   BI163658   BI167824   BI170683   BI215754   BI234871   BI234908   BI236199   BI238901   BI352014   BI352272   BI358340   BI363390   BI364974   BI372143   BI564759   BI565454   BI573645   BI573646   BI586841   BI592997   BI609094   BI611401   BI612120   BI629332   BI633792   BI634713   BI635649   BI636462   BI636837   BI637109   BI639289   BI639858   BI641716   BP540226   BP549632   BP551256   BP553228   BP560097   BQ103236   BX049516   CO194664   CO270878   CO276592   CO292502   CO305231   CO339941   EC063646   EC065158   EC065816   EC082350   EC083081   EC240953   EV597635   EV599599   GH756686   GH776109   GH776957   GH777800   GH780365   GH783126   GH783712   GH791279   GH803982   GH809245   GH810593   GH812427   GH814789   GH816124   GH816685   GH817021   GH817087   GH817783   GH820733   GH821063   GH821784   GH823245   GH824093   GH846440   GH851915   GH856017   GH858510   GH858888   GH860855   GH861136   GH861172   GH862553   GH863719   GH865771   GH866880   GH869638   GH870970   GH872679   GH875378   GH877775   GH885918   GH889785   GH890850   GH896222   GH913233   GH914339   GH914860   GH917742   GH922233   GH924052   GH924183   GH924725   GH928270   GH928339   GH928773   GH929389   GH933384   GH934136   GH937581
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VV60
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage   embryonic/larval salivary gland   (Seshaiah and Andrew, 1999) organism | ubiquitous   (Seshaiah and Andrew, 1999) embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 13 -- 16   organism | ubiquitous   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    243.8 Larval Midgut    276.9 Larval Hindgut    283.7 Larval Malpighian Tubules    339 Larval Fat Body    272.3 Larval Salivary Gland    368.3 Larval Trachea    357.775 Larval Carcass    423.875 Adult Head    211.7 Adult Eye    266.675 Adult Brain    159.4 Adult Thoracic-Abdominal Ganglion    356.6 Adult Crop    257.6 Adult Midgut    281.7 Adult Hindgut    257.5 Adult Malpighian Tubules    344 Adult Fat Body    342 Adult Salivary Gland    216.8 Adult Heart    273.5 Adult VirginFemale Spermatheca    351.5 Adult InseminatedFemale Spermatheca    392.1 Adult Ovary    279.7 Adult Testis    86.8 Adult Male Accessory Gland    345.8 Adult Carcass    260.4 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    243.8 Larval Midgut    276.9 Larval Hindgut    283.7 Larval Malpighian Tubules    339 Larval Fat Body    272.3 Larval Salivary Gland    368.3 Larval Trachea    357.775 Larval Carcass    423.875 Adult Head    211.7 Adult Eye    266.675 Adult Brain    159.4 Adult Thoracic-Abdominal Ganglion    356.6 Adult Crop    257.6 Adult Midgut    281.7 Adult Hindgut    257.5 Adult Malpighian Tubules    344 Adult Fat Body    342 Adult Salivary Gland    216.8 Adult Heart    273.5 Adult VirginFemale Spermatheca    351.5 Adult InseminatedFemale Spermatheca    392.1 Adult Ovary    279.7 Adult Testis    86.8 Adult Male Accessory Gland    345.8 Adult Carcass    260.4 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    243.8 Larval Midgut    276.9 Larval Hindgut    283.7 Larval Malpighian Tubules    339 Larval Fat Body    272.3 Larval Salivary Gland    368.3 Larval Trachea    357.775 Larval Carcass    423.875 Adult Head    211.7 Adult Eye    266.675 Adult Brain    159.4 Adult Thoracic-Abdominal Ganglion    356.6 Adult Crop    257.6 Adult Midgut    281.7 Adult Hindgut    257.5 Adult Malpighian Tubules    344 Adult Fat Body    342 Adult Salivary Gland    216.8 Adult Heart    273.5 Adult VirginFemale Spermatheca    351.5 Adult InseminatedFemale Spermatheca    392.1 Adult Ovary    279.7 Adult Testis    86.8 Adult Male Accessory Gland    345.8 Adult Carcass    260.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    243.8 Larval Midgut    276.9 Larval Hindgut    283.7 Larval Malpighian Tubules    339 Larval Fat Body    272.3 Larval Salivary Gland    368.3 Larval Trachea    357.775 Larval Carcass    423.875 Adult Head    211.7 Adult Eye    266.675 Adult Brain    159.4 Adult Thoracic-Abdominal Ganglion    356.6 Adult Crop    257.6 Adult Midgut    281.7 Adult Hindgut    257.5 Adult Malpighian Tubules    344 Adult Fat Body    342 Adult Salivary Gland    216.8 Adult Heart    273.5 Adult VirginFemale Spermatheca    351.5 Adult InseminatedFemale Spermatheca    392.1 Adult Ovary    279.7 Adult Testis    86.8 Adult Male Accessory Gland    345.8 Adult Carcass    260.4 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    243.8 Larval Midgut    276.9 Larval Hindgut    283.7 Larval Malpighian Tubules    339 Larval Fat Body    272.3 Larval Salivary Gland    368.3 Larval Trachea    357.775 Larval Carcass    423.875 Adult Head    211.7 Adult Eye    266.675 Adult Brain    159.4 Adult Thoracic-Abdominal Ganglion    356.6 Adult Crop    257.6 Adult Midgut    281.7 Adult Hindgut    257.5 Adult Malpighian Tubules    344 Adult Fat Body    342 Adult Salivary Gland    216.8 Adult Heart    273.5 Adult VirginFemale Spermatheca    351.5 Adult InseminatedFemale Spermatheca    392.1 Adult Ovary    279.7 Adult Testis    86.8 Adult Male Accessory Gland    345.8 Adult Carcass    260.4 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    243.8 Larval Midgut    276.9 Larval Hindgut    283.7 Larval Malpighian Tubules    339 Larval Fat Body    272.3 Larval Salivary Gland    368.3 Larval Trachea    357.775 Larval Carcass    423.875 Adult Head    211.7 Adult Eye    266.675 Adult Brain    159.4 Adult Thoracic-Abdominal Ganglion    356.6 Adult Crop    257.6 Adult Midgut    281.7 Adult Hindgut    257.5 Adult Malpighian Tubules    344 Adult Fat Body    342 Adult Salivary Gland    216.8 Adult Heart    273.5 Adult VirginFemale Spermatheca    351.5 Adult InseminatedFemale Spermatheca    392.1 Adult Ovary    279.7 Adult Testis    86.8 Adult Male Accessory Gland    345.8 Adult Carcass    260.4 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    243.8 Larval Midgut    276.9 Larval Hindgut    283.7 Larval Malpighian Tubules    339 Larval Fat Body    272.3 Larval Salivary Gland    368.3 Larval Trachea    357.775 Larval Carcass    423.875 Adult Head    211.7 Adult Eye    266.675 Adult Brain    159.4 Adult Thoracic-Abdominal Ganglion    356.6 Adult Crop    257.6 Adult Midgut    281.7 Adult Hindgut    257.5 Adult Malpighian Tubules    344 Adult Fat Body    342 Adult Salivary Gland    216.8 Adult Heart    273.5 Adult VirginFemale Spermatheca    351.5 Adult InseminatedFemale Spermatheca    392.1 Adult Ovary    279.7 Adult Testis    86.8 Adult Male Accessory Gland    345.8 Adult Carcass    260.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    243.8 Larval Midgut    276.9 Larval Hindgut    283.7 Larval Malpighian Tubules    339 Larval Fat Body    272.3 Larval Salivary Gland    368.3 Larval Trachea    357.775 Larval Carcass    423.875 Adult Head    211.7 Adult Eye    266.675 Adult Brain    159.4 Adult Thoracic-Abdominal Ganglion    356.6 Adult Crop    257.6 Adult Midgut    281.7 Adult Hindgut    257.5 Adult Malpighian Tubules    344 Adult Fat Body    342 Adult Salivary Gland    216.8 Adult Heart    273.5 Adult VirginFemale Spermatheca    351.5 Adult InseminatedFemale Spermatheca    392.1 Adult Ovary    279.7 Adult Testis    86.8 Adult Male Accessory Gland    345.8 Adult Carcass    260.4 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    211.7   NA  Eye    266.675   NA  Brain    159.4   243.8  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    356.6   NA  Crop    257.6   276.9  Midgut    281.7   283.7  Hindgut    257.5   339  Malpighian Tubules    344   272.3  Fat Body    342   368.3  Salivary Gland    216.8   NA  Heart    273.5   357.775  Trachea    NA   NA  VirginFemale Spermatheca    351.5   NA  InseminatedFemale Spermatheca    392.1   NA  Ovary    279.7   NA  Testis    86.8   NA  Male Accessory Gland    345.8   423.875  Carcass    260.4 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    36 central nervous system, larvae L3    36 central nervous system, pupae P8    17 head, virgin 1-day female    25 head, virgin 4-day female    26 head, virgin 20-day female    26 head, mated 1-day female    26 head, mated 4-day female    32 head, mated 20-day female    22 head, mated 1-day male    24 head, mated 4-day male    26 head, mated 20-day male    26 salivary gland, larvae L3 wandering    16 salivary gland, white prepupae    43 digestive system, larvae L3 wandering    29 digestive system, 1-day adult    36 digestive system, 4-day adult    34 digestive system, 20-day adult    29 fat body, larvae L3 wandering    28 fat body, white prepupae    26 fat body, pupae P8    52 carcass, larvae L3 wandering    50 carcass, 1-day adult    22 carcass, 4-day adult    29 carcass, 20-day adult    24 ovary, virgin 4-day female    62 ovary, mated 4-day female    51 testis, mated 4-day male    33 accessory gland, mated 4-day male    26 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (36) central nervous system, larvae L3  (36) central nervous system, pupae P8    17 head, virgin 1-day female    25 head, virgin 4-day female  26 head, virgin 20-day female  26 head, mated 1-day female  26 head, mated 4-day female  (32) head, mated 20-day female    22 head, mated 1-day male    24 head, mated 4-day male  26 head, mated 20-day male  26 salivary gland, larvae L3 wandering    16 salivary gland, white prepupae  (43) digestive system, larvae L3 wandering  (29) digestive system, 1-day adult  (36) digestive system, 4-day adult  (34) digestive system, 20-day adult  (29) fat body, larvae L3 wandering  (28) fat body, white prepupae  26 fat body, pupae P8  (52) carcass, larvae L3 wandering  (50) carcass, 1-day adult    22 carcass, 4-day adult  (29) carcass, 20-day adult    24 ovary, virgin 4-day female  (62) ovary, mated 4-day female  (51) testis, mated 4-day male  (33) accessory gland, mated 4-day male  26 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    36 central nervous system, larvae L3    36 central nervous system, pupae P8    17 head, virgin 1-day female    25 head, virgin 4-day female    26 head, virgin 20-day female    26 head, mated 1-day female    26 head, mated 4-day female    32 head, mated 20-day female    22 head, mated 1-day male    24 head, mated 4-day male    26 head, mated 20-day male    26 salivary gland, larvae L3 wandering    16 salivary gland, white prepupae    43 digestive system, larvae L3 wandering    29 digestive system, 1-day adult    36 digestive system, 4-day adult    34 digestive system, 20-day adult    29 fat body, larvae L3 wandering    28 fat body, white prepupae    26 fat body, pupae P8    52 carcass, larvae L3 wandering    50 carcass, 1-day adult    22 carcass, 4-day adult    29 carcass, 20-day adult    24 ovary, virgin 4-day female    62 ovary, mated 4-day female    51 testis, mated 4-day male    33 accessory gland, mated 4-day male    26 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    36 central nervous system, larvae L3    36 central nervous system, pupae P8    17 head, virgin 1-day female    25 head, virgin 4-day female    26 head, virgin 20-day female    26 head, mated 1-day female    26 head, mated 4-day female    32 head, mated 20-day female    22 head, mated 1-day male    24 head, mated 4-day male    26 head, mated 20-day male    26 salivary gland, larvae L3 wandering    16 salivary gland, white prepupae    43 digestive system, larvae L3 wandering    29 digestive system, 1-day adult    36 digestive system, 4-day adult    34 digestive system, 20-day adult    29 fat body, larvae L3 wandering    28 fat body, white prepupae    26 fat body, pupae P8    52 carcass, larvae L3 wandering    50 carcass, 1-day adult    22 carcass, 4-day adult    29 carcass, 20-day adult    24 ovary, virgin 4-day female    62 ovary, mated 4-day female    51 testis, mated 4-day male    33 accessory gland, mated 4-day male    26 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    36 central nervous system, larvae L3    36 central nervous system, pupae P8    17 head, virgin 1-day female    25 head, virgin 4-day female    26 head, virgin 20-day female    26 head, mated 1-day female    26 head, mated 4-day female    32 head, mated 20-day female    22 head, mated 1-day male    24 head, mated 4-day male    26 head, mated 20-day male    26 salivary gland, larvae L3 wandering    16 salivary gland, white prepupae    43 digestive system, larvae L3 wandering    29 digestive system, 1-day adult    36 digestive system, 4-day adult    34 digestive system, 20-day adult    29 fat body, larvae L3 wandering    28 fat body, white prepupae    26 fat body, pupae P8    52 carcass, larvae L3 wandering    50 carcass, 1-day adult    22 carcass, 4-day adult    29 carcass, 20-day adult    24 ovary, virgin 4-day female    62 ovary, mated 4-day female    51 testis, mated 4-day male    33 accessory gland, mated 4-day male    26 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (36) central nervous system, larvae L3  (36) central nervous system, pupae P8    17 head, virgin 1-day female    25 head, virgin 4-day female  26 head, virgin 20-day female  26 head, mated 1-day female  26 head, mated 4-day female  32 head, mated 20-day female    22 head, mated 1-day male    24 head, mated 4-day male  26 head, mated 20-day male  26 salivary gland, larvae L3 wandering    16 salivary gland, white prepupae  (43) digestive system, larvae L3 wandering  29 digestive system, 1-day adult  (36) digestive system, 4-day adult  (34) digestive system, 20-day adult  29 fat body, larvae L3 wandering  28 fat body, white prepupae  26 fat body, pupae P8  (52) carcass, larvae L3 wandering  (50) carcass, 1-day adult    22 carcass, 4-day adult  29 carcass, 20-day adult    24 ovary, virgin 4-day female  (62) ovary, mated 4-day female  (51) testis, mated 4-day male  (33) accessory gland, mated 4-day male  26 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    36 central nervous system, larvae L3    36 central nervous system, pupae P8    17 head, virgin 1-day female    25 head, virgin 4-day female    26 head, virgin 20-day female    26 head, mated 1-day female    26 head, mated 4-day female    32 head, mated 20-day female    22 head, mated 1-day male    24 head, mated 4-day male    26 head, mated 20-day male    26 salivary gland, larvae L3 wandering    16 salivary gland, white prepupae    43 digestive system, larvae L3 wandering    29 digestive system, 1-day adult    36 digestive system, 4-day adult    34 digestive system, 20-day adult    29 fat body, larvae L3 wandering    28 fat body, white prepupae    26 fat body, pupae P8    52 carcass, larvae L3 wandering    50 carcass, 1-day adult    22 carcass, 4-day adult    29 carcass, 20-day adult    24 ovary, virgin 4-day female    62 ovary, mated 4-day female    51 testis, mated 4-day male    33 accessory gland, mated 4-day male    26 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    36 central nervous system, larvae L3    36 central nervous system, pupae P8    17 head, virgin 1-day female    25 head, virgin 4-day female    26 head, virgin 20-day female    26 head, mated 1-day female    26 head, mated 4-day female    32 head, mated 20-day female    22 head, mated 1-day male    24 head, mated 4-day male    26 head, mated 20-day male    26 salivary gland, larvae L3 wandering    16 salivary gland, white prepupae    43 digestive system, larvae L3 wandering    29 digestive system, 1-day adult    36 digestive system, 4-day adult    34 digestive system, 20-day adult    29 fat body, larvae L3 wandering    28 fat body, white prepupae    26 fat body, pupae P8    52 carcass, larvae L3 wandering    50 carcass, 1-day adult    22 carcass, 4-day adult    29 carcass, 20-day adult    24 ovary, virgin 4-day female    62 ovary, mated 4-day female    51 testis, mated 4-day male    33 accessory gland, mated 4-day male    26 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed at stages throughout embryogenesis, during early larval stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    81 embryo 02-04hr    104 embryo 04-06hr    110 embryo 06-08hr    75 embryo 08-10hr    90 embryo 10-12hr    89 embryo 12-14hr    61 embryo 14-16hr    64 embryo 16-18hr    58 embryo 18-20hr    60 embryo 20-22hr    66 embryo 22-24hr    63 larva L1    99 larva L2    99 larva L3 12hr old    75 larva L3 puffstage 1-2    47 larva L3 puffstage 3-6    45 larva L3 puffstage 7-9    52 white prepupae new    50 white prepupae 12hr    43 white prepupae 24hr    42 pupae 2d postWPP    41 pupae 3d postWPP    29 pupae 4d postWPP    33 adult male 01day    33 adult male 05day    31 adult male 30day    26 adult female 01day    67 adult female 05day    82 adult female 30day    85 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (81) embryo 02-04hr  (104) embryo 04-06hr  (110) embryo 06-08hr  (75) embryo 08-10hr  (90) embryo 10-12hr  (89) embryo 12-14hr  (61) embryo 14-16hr  (64) embryo 16-18hr  (58) embryo 18-20hr  (60) embryo 20-22hr  (66) embryo 22-24hr  (63) larva L1  (99) larva L2  (99) larva L3 12hr old  (75) larva L3 puffstage 1-2  (47) larva L3 puffstage 3-6  (45) larva L3 puffstage 7-9  (52) white prepupae new  (50) white prepupae 12hr  (43) white prepupae 24hr  (42) pupae 2d postWPP  (41) pupae 3d postWPP  (29) pupae 4d postWPP  (33) adult male 01day  (33) adult male 05day  (31) adult male 30day  26 adult female 01day  (67) adult female 05day  (82) adult female 30day  (85) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    81 embryo 02-04hr  104 embryo 04-06hr  (110) embryo 06-08hr    75 embryo 08-10hr    90 embryo 10-12hr    89 embryo 12-14hr    61 embryo 14-16hr    64 embryo 16-18hr    58 embryo 18-20hr    60 embryo 20-22hr    66 embryo 22-24hr    63 larva L1    99 larva L2    99 larva L3 12hr old    75 larva L3 puffstage 1-2    47 larva L3 puffstage 3-6    45 larva L3 puffstage 7-9    52 white prepupae new    50 white prepupae 12hr    43 white prepupae 24hr    42 pupae 2d postWPP    41 pupae 3d postWPP    29 pupae 4d postWPP    33 adult male 01day    33 adult male 05day    31 adult male 30day    26 adult female 01day    67 adult female 05day    82 adult female 30day    85 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    81 embryo 02-04hr    104 embryo 04-06hr    110 embryo 06-08hr    75 embryo 08-10hr    90 embryo 10-12hr    89 embryo 12-14hr    61 embryo 14-16hr    64 embryo 16-18hr    58 embryo 18-20hr    60 embryo 20-22hr    66 embryo 22-24hr    63 larva L1    99 larva L2    99 larva L3 12hr old    75 larva L3 puffstage 1-2    47 larva L3 puffstage 3-6    45 larva L3 puffstage 7-9    52 white prepupae new    50 white prepupae 12hr    43 white prepupae 24hr    42 pupae 2d postWPP    41 pupae 3d postWPP    29 pupae 4d postWPP    33 adult male 01day    33 adult male 05day    31 adult male 30day    26 adult female 01day    67 adult female 05day    82 adult female 30day    85 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    81 embryo 02-04hr    104 embryo 04-06hr    110 embryo 06-08hr    75 embryo 08-10hr    90 embryo 10-12hr    89 embryo 12-14hr    61 embryo 14-16hr    64 embryo 16-18hr    58 embryo 18-20hr    60 embryo 20-22hr    66 embryo 22-24hr    63 larva L1    99 larva L2    99 larva L3 12hr old    75 larva L3 puffstage 1-2    47 larva L3 puffstage 3-6    45 larva L3 puffstage 7-9    52 white prepupae new    50 white prepupae 12hr    43 white prepupae 24hr    42 pupae 2d postWPP    41 pupae 3d postWPP    29 pupae 4d postWPP    33 adult male 01day    33 adult male 05day    31 adult male 30day    26 adult female 01day    67 adult female 05day    82 adult female 30day    85 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (81) embryo 02-04hr  (104) embryo 04-06hr  (110) embryo 06-08hr  (75) embryo 08-10hr  (90) embryo 10-12hr  (89) embryo 12-14hr  (61) embryo 14-16hr  (64) embryo 16-18hr  (58) embryo 18-20hr  (60) embryo 20-22hr  (66) embryo 22-24hr  (63) larva L1  (99) larva L2  (99) larva L3 12hr old  (75) larva L3 puffstage 1-2  (47) larva L3 puffstage 3-6  (45) larva L3 puffstage 7-9  (52) white prepupae new  (50) white prepupae 12hr  (43) white prepupae 24hr  (42) pupae 2d postWPP  (41) pupae 3d postWPP  29 pupae 4d postWPP  (33) adult male 01day  (33) adult male 05day  31 adult male 30day  26 adult female 01day  (67) adult female 05day  (82) adult female 30day  (85) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    81 embryo 02-04hr  104 embryo 04-06hr  110 embryo 06-08hr    75 embryo 08-10hr    90 embryo 10-12hr    89 embryo 12-14hr    61 embryo 14-16hr    64 embryo 16-18hr    58 embryo 18-20hr    60 embryo 20-22hr    66 embryo 22-24hr    63 larva L1    99 larva L2    99 larva L3 12hr old    75 larva L3 puffstage 1-2    47 larva L3 puffstage 3-6    45 larva L3 puffstage 7-9    52 white prepupae new    50 white prepupae 12hr    43 white prepupae 24hr    42 pupae 2d postWPP    41 pupae 3d postWPP    29 pupae 4d postWPP    33 adult male 01day    33 adult male 05day    31 adult male 30day    26 adult female 01day    67 adult female 05day    82 adult female 30day    85 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    81 embryo 02-04hr    104 embryo 04-06hr    110 embryo 06-08hr    75 embryo 08-10hr    90 embryo 10-12hr    89 embryo 12-14hr    61 embryo 14-16hr    64 embryo 16-18hr    58 embryo 18-20hr    60 embryo 20-22hr    66 embryo 22-24hr    63 larva L1    99 larva L2    99 larva L3 12hr old    75 larva L3 puffstage 1-2    47 larva L3 puffstage 3-6    45 larva L3 puffstage 7-9    52 white prepupae new    50 white prepupae 12hr    43 white prepupae 24hr    42 pupae 2d postWPP    41 pupae 3d postWPP    29 pupae 4d postWPP    33 adult male 01day    33 adult male 05day    31 adult male 30day    26 adult female 01day    67 adult female 05day    82 adult female 30day    85 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    74 Schneider line 2 Sg4    127 embryonic 1182-4H    80 embryonic GM2    89 embryonic Kc167    107 embryonic S1    66 embryonic S3    45 leg disc CME L1    140 wing disc CME-W2    59 wing disc ML-DmD8    43 wing disc ML-DmD9    104 wing disc ML-DmD16-c3    54 wing disc ML-DmD21    73 wing disc ML-DmD32    38 haltere disc ML-DmD17-c3    40 eye-antennal disc ML-DmD11    77 antennal disc ML-DmD20-c5    83 mixed discs ML-DmD4-c1    94 CNS ML-DmBG1-c1    78 CNS ML-DmBG2-c2    48 tumorous blood cells mbn2    53 ovary fGS/OSS    25 ovary OSC    36 ovary OSS    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (74) Schneider line 2 Sg4  (127) embryonic 1182-4H  (80) embryonic GM2  (89) embryonic Kc167  (107) embryonic S1  (66) embryonic S3  (45) leg disc CME L1  (140) wing disc CME-W2  (59) wing disc ML-DmD8  (43) wing disc ML-DmD9  (104) wing disc ML-DmD16-c3  (54) wing disc ML-DmD21  (73) wing disc ML-DmD32  (38) haltere disc ML-DmD17-c3  (40) eye-antennal disc ML-DmD11  (77) antennal disc ML-DmD20-c5  (83) mixed discs ML-DmD4-c1  (94) CNS ML-DmBG1-c1  (78) CNS ML-DmBG2-c2  (48) tumorous blood cells mbn2  (53) ovary fGS/OSS    25 ovary OSC  (36) ovary OSS    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    74 Schneider line 2 Sg4  (127) embryonic 1182-4H    80 embryonic GM2    89 embryonic Kc167  107 embryonic S1    66 embryonic S3    45 leg disc CME L1  (140) wing disc CME-W2    59 wing disc ML-DmD8    43 wing disc ML-DmD9  104 wing disc ML-DmD16-c3    54 wing disc ML-DmD21    73 wing disc ML-DmD32    38 haltere disc ML-DmD17-c3    40 eye-antennal disc ML-DmD11    77 antennal disc ML-DmD20-c5    83 mixed discs ML-DmD4-c1    94 CNS ML-DmBG1-c1    78 CNS ML-DmBG2-c2    48 tumorous blood cells mbn2    53 ovary fGS/OSS    25 ovary OSC    36 ovary OSS    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    74 Schneider line 2 Sg4    127 embryonic 1182-4H    80 embryonic GM2    89 embryonic Kc167    107 embryonic S1    66 embryonic S3    45 leg disc CME L1    140 wing disc CME-W2    59 wing disc ML-DmD8    43 wing disc ML-DmD9    104 wing disc ML-DmD16-c3    54 wing disc ML-DmD21    73 wing disc ML-DmD32    38 haltere disc ML-DmD17-c3    40 eye-antennal disc ML-DmD11    77 antennal disc ML-DmD20-c5    83 mixed discs ML-DmD4-c1    94 CNS ML-DmBG1-c1    78 CNS ML-DmBG2-c2    48 tumorous blood cells mbn2    53 ovary fGS/OSS    25 ovary OSC    36 ovary OSS    14 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    74 Schneider line 2 Sg4    127 embryonic 1182-4H    80 embryonic GM2    89 embryonic Kc167    107 embryonic S1    66 embryonic S3    45 leg disc CME L1    140 wing disc CME-W2    59 wing disc ML-DmD8    43 wing disc ML-DmD9    104 wing disc ML-DmD16-c3    54 wing disc ML-DmD21    73 wing disc ML-DmD32    38 haltere disc ML-DmD17-c3    40 eye-antennal disc ML-DmD11    77 antennal disc ML-DmD20-c5    83 mixed discs ML-DmD4-c1    94 CNS ML-DmBG1-c1    78 CNS ML-DmBG2-c2    48 tumorous blood cells mbn2    53 ovary fGS/OSS    25 ovary OSC    36 ovary OSS    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (74) Schneider line 2 Sg4  (127) embryonic 1182-4H  (80) embryonic GM2  (89) embryonic Kc167  (107) embryonic S1  (66) embryonic S3  (45) leg disc CME L1  (140) wing disc CME-W2  (59) wing disc ML-DmD8  (43) wing disc ML-DmD9  (104) wing disc ML-DmD16-c3  (54) wing disc ML-DmD21  (73) wing disc ML-DmD32  (38) haltere disc ML-DmD17-c3  (40) eye-antennal disc ML-DmD11  (77) antennal disc ML-DmD20-c5  (83) mixed discs ML-DmD4-c1  (94) CNS ML-DmBG1-c1  (78) CNS ML-DmBG2-c2  (48) tumorous blood cells mbn2  (53) ovary fGS/OSS    25 ovary OSC  (36) ovary OSS    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    74 Schneider line 2 Sg4  127 embryonic 1182-4H    80 embryonic GM2    89 embryonic Kc167  107 embryonic S1    66 embryonic S3    45 leg disc CME L1  140 wing disc CME-W2    59 wing disc ML-DmD8    43 wing disc ML-DmD9  104 wing disc ML-DmD16-c3    54 wing disc ML-DmD21    73 wing disc ML-DmD32    38 haltere disc ML-DmD17-c3    40 eye-antennal disc ML-DmD11    77 antennal disc ML-DmD20-c5    83 mixed discs ML-DmD4-c1    94 CNS ML-DmBG1-c1    78 CNS ML-DmBG2-c2    48 tumorous blood cells mbn2    53 ovary fGS/OSS    25 ovary OSC    36 ovary OSS    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    74 Schneider line 2 Sg4    127 embryonic 1182-4H    80 embryonic GM2    89 embryonic Kc167    107 embryonic S1    66 embryonic S3    45 leg disc CME L1    140 wing disc CME-W2    59 wing disc ML-DmD8    43 wing disc ML-DmD9    104 wing disc ML-DmD16-c3    54 wing disc ML-DmD21    73 wing disc ML-DmD32    38 haltere disc ML-DmD17-c3    40 eye-antennal disc ML-DmD11    77 antennal disc ML-DmD20-c5    83 mixed discs ML-DmD4-c1    94 CNS ML-DmBG1-c1    78 CNS ML-DmBG2-c2    48 tumorous blood cells mbn2    53 ovary fGS/OSS    25 ovary OSC    36 ovary OSS    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    13 heat shock, 4-day adult    46 Cadmium 50 mM 6 hrs, larvae L3    45 Cadmium 50 mM 12 hrs, larvae L3    36 Cadmium 50 mM 48 hrs, 4-day adult    50 Cadmium 100 mM 48 hrs, 4-day adult    46 Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult    32 Zinc 5 mM 12 hrs, larvae L3    16 Zinc 4.5 mM 48 hrs, 4-day adult    26 Ethanol 2.5% 3 hrs, larvae L3    54 Ethanol 5% 3 hrs, larvae L3    52 Ethanol 10% 3 hrs, larvae L3    41 Caffeine 1.5 mg/ml 4 hrs, larvae L3    42 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    47 Caffeine 25 mg/ml 48 hrs, 4-day adult    21 Paraquat 5 mM 48 hrs, 4-day adult    41 Paraquat 10 mM 48 hrs, 4-day adult    59 Rotenone 2 μg 12 hrs, larvae L3    47 Rotenone 8 μg 12 hrs, larvae L3    59 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    13 heat shock, 4-day adult  (46) Cadmium 50 mM 6 hrs, larvae L3  (45) Cadmium 50 mM 12 hrs, larvae L3  (36) Cadmium 50 mM 48 hrs, 4-day adult  (50) Cadmium 100 mM 48 hrs, 4-day adult  (46) Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult  (32) Zinc 5 mM 12 hrs, larvae L3    16 Zinc 4.5 mM 48 hrs, 4-day adult  26 Ethanol 2.5% 3 hrs, larvae L3  (54) Ethanol 5% 3 hrs, larvae L3  (52) Ethanol 10% 3 hrs, larvae L3  (41) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (42) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (47) Caffeine 25 mg/ml 48 hrs, 4-day adult    21 Paraquat 5 mM 48 hrs, 4-day adult  (41) Paraquat 10 mM 48 hrs, 4-day adult  (59) Rotenone 2 μg 12 hrs, larvae L3  (47) Rotenone 8 μg 12 hrs, larvae L3  (59) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    13 heat shock, 4-day adult    46 Cadmium 50 mM 6 hrs, larvae L3    45 Cadmium 50 mM 12 hrs, larvae L3    36 Cadmium 50 mM 48 hrs, 4-day adult    50 Cadmium 100 mM 48 hrs, 4-day adult    46 Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult    32 Zinc 5 mM 12 hrs, larvae L3    16 Zinc 4.5 mM 48 hrs, 4-day adult    26 Ethanol 2.5% 3 hrs, larvae L3    54 Ethanol 5% 3 hrs, larvae L3    52 Ethanol 10% 3 hrs, larvae L3    41 Caffeine 1.5 mg/ml 4 hrs, larvae L3    42 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    47 Caffeine 25 mg/ml 48 hrs, 4-day adult    21 Paraquat 5 mM 48 hrs, 4-day adult    41 Paraquat 10 mM 48 hrs, 4-day adult    59 Rotenone 2 μg 12 hrs, larvae L3    47 Rotenone 8 μg 12 hrs, larvae L3    59 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    13 heat shock, 4-day adult    46 Cadmium 50 mM 6 hrs, larvae L3    45 Cadmium 50 mM 12 hrs, larvae L3    36 Cadmium 50 mM 48 hrs, 4-day adult    50 Cadmium 100 mM 48 hrs, 4-day adult    46 Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult    32 Zinc 5 mM 12 hrs, larvae L3    16 Zinc 4.5 mM 48 hrs, 4-day adult    26 Ethanol 2.5% 3 hrs, larvae L3    54 Ethanol 5% 3 hrs, larvae L3    52 Ethanol 10% 3 hrs, larvae L3    41 Caffeine 1.5 mg/ml 4 hrs, larvae L3    42 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    47 Caffeine 25 mg/ml 48 hrs, 4-day adult    21 Paraquat 5 mM 48 hrs, 4-day adult    41 Paraquat 10 mM 48 hrs, 4-day adult    59 Rotenone 2 μg 12 hrs, larvae L3    47 Rotenone 8 μg 12 hrs, larvae L3    59 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    13 heat shock, 4-day adult    46 Cadmium 50 mM 6 hrs, larvae L3    45 Cadmium 50 mM 12 hrs, larvae L3    36 Cadmium 50 mM 48 hrs, 4-day adult    50 Cadmium 100 mM 48 hrs, 4-day adult    46 Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult    32 Zinc 5 mM 12 hrs, larvae L3    16 Zinc 4.5 mM 48 hrs, 4-day adult    26 Ethanol 2.5% 3 hrs, larvae L3    54 Ethanol 5% 3 hrs, larvae L3    52 Ethanol 10% 3 hrs, larvae L3    41 Caffeine 1.5 mg/ml 4 hrs, larvae L3    42 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    47 Caffeine 25 mg/ml 48 hrs, 4-day adult    21 Paraquat 5 mM 48 hrs, 4-day adult    41 Paraquat 10 mM 48 hrs, 4-day adult    59 Rotenone 2 μg 12 hrs, larvae L3    47 Rotenone 8 μg 12 hrs, larvae L3    59 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    13 heat shock, 4-day adult  (46) Cadmium 50 mM 6 hrs, larvae L3  (45) Cadmium 50 mM 12 hrs, larvae L3  (36) Cadmium 50 mM 48 hrs, 4-day adult  (50) Cadmium 100 mM 48 hrs, 4-day adult  (46) Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult  32 Zinc 5 mM 12 hrs, larvae L3    16 Zinc 4.5 mM 48 hrs, 4-day adult  26 Ethanol 2.5% 3 hrs, larvae L3  (54) Ethanol 5% 3 hrs, larvae L3  (52) Ethanol 10% 3 hrs, larvae L3  (41) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (42) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (47) Caffeine 25 mg/ml 48 hrs, 4-day adult    21 Paraquat 5 mM 48 hrs, 4-day adult  (41) Paraquat 10 mM 48 hrs, 4-day adult  (59) Rotenone 2 μg 12 hrs, larvae L3  (47) Rotenone 8 μg 12 hrs, larvae L3  (59) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    13 heat shock, 4-day adult    46 Cadmium 50 mM 6 hrs, larvae L3    45 Cadmium 50 mM 12 hrs, larvae L3    36 Cadmium 50 mM 48 hrs, 4-day adult    50 Cadmium 100 mM 48 hrs, 4-day adult    46 Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult    32 Zinc 5 mM 12 hrs, larvae L3    16 Zinc 4.5 mM 48 hrs, 4-day adult    26 Ethanol 2.5% 3 hrs, larvae L3    54 Ethanol 5% 3 hrs, larvae L3    52 Ethanol 10% 3 hrs, larvae L3    41 Caffeine 1.5 mg/ml 4 hrs, larvae L3    42 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    47 Caffeine 25 mg/ml 48 hrs, 4-day adult    21 Paraquat 5 mM 48 hrs, 4-day adult    41 Paraquat 10 mM 48 hrs, 4-day adult    59 Rotenone 2 μg 12 hrs, larvae L3    47 Rotenone 8 μg 12 hrs, larvae L3    59 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    13 heat shock, 4-day adult    46 Cadmium 50 mM 6 hrs, larvae L3    45 Cadmium 50 mM 12 hrs, larvae L3    36 Cadmium 50 mM 48 hrs, 4-day adult    50 Cadmium 100 mM 48 hrs, 4-day adult    46 Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult    32 Zinc 5 mM 12 hrs, larvae L3    16 Zinc 4.5 mM 48 hrs, 4-day adult    26 Ethanol 2.5% 3 hrs, larvae L3    54 Ethanol 5% 3 hrs, larvae L3    52 Ethanol 10% 3 hrs, larvae L3    41 Caffeine 1.5 mg/ml 4 hrs, larvae L3    42 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    47 Caffeine 25 mg/ml 48 hrs, 4-day adult    21 Paraquat 5 mM 48 hrs, 4-day adult    41 Paraquat 10 mM 48 hrs, 4-day adult    59 Rotenone 2 μg 12 hrs, larvae L3    47 Rotenone 8 μg 12 hrs, larvae L3    59 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_08 mE1_20_mRNA_expression_cluster_02
External Data & Images
Linkouts	BDGP expression data • LD21116 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0027080 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4561-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4Act5C.PI Aats-tyrE196K.Scer\UAS lethal, with Scer\GAL4pnr-MD237 Aats-tyrGD11353 partially lethal - majority die, with Scer\GAL4Act5C.PI Aats-tyr153-156delVKQV.Scer\UAS Aats-tyrG41R.Scer\UAS viable, with Scer\GAL4Act5C.PI Aats-tyrK264N.Scer\UAS Aats-tyrScer\UAS.cSa viable, with Scer\GAL4n-syb.PS Aats-tyrK264N.Scer\UAS Aats-tyrScer\UAS.cSa Other Phenotypes Allele decreased cell size | cell autonomous | somatic clone, with Scer\GAL4Act5C.PP Aats-tyrdsRNA.Scer\UAS.NIG flightless, with Scer\GAL4Act5C.PU Aats-tyr153-156delVKQV.Scer\UAS Aats-tyrE196K.Scer\UAS Aats-tyrG41R.Scer\UAS jumping defective, with Scer\GAL4Act5C.PU Aats-tyrE196K.Scer\UAS locomotor behavior defective, with Scer\GAL4Act5C.PU Aats-tyr153-156delVKQV.Scer\UAS Aats-tyrE196K.Scer\UAS Aats-tyrG41R.Scer\UAS locomotor behavior defective, with Scer\GAL4n-syb.PS Aats-tyr153-156delVKQV.Scer\UAS Aats-tyrE196K.Scer\UAS Aats-tyrG41R.Scer\UAS neurophysiology defective | adult stage Aats-tyr153-156delVKQV.Scer\UAS neurophysiology defective | adult stage, with Scer\GAL4A307 Aats-tyr153-156delVKQV.Scer\UAS Aats-tyrE196K.Scer\UAS Aats-tyrG41R.Scer\UAS Phenotype manifest in Allele giant fiber neuron Aats-tyr153-156delVKQV.Scer\UAS giant fiber neuron, with Scer\GAL4A307 Aats-tyrE196K.Scer\UAS Aats-tyrG41R.Scer\UAS Aats-tyr153-156delVKQV.Scer\UAS lysosome & larval fat body | somatic clone | cell autonomous, with Scer\GAL4Act5C.PP Aats-tyrdsRNA.Scer\UAS.NIG scutellar bristle, with Scer\GAL4sca.PU Aats-tyrNIG.4561R
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of Aats-tyr Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Aats-tyr Class Mutagen Stocks Known lesion Aats-tyrGD11353 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Aats-tyrKK100551 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Aats-tyr153-156delVKQV.Scer\UAS in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes Aats-tyrdsRNA.Scer\UAS.NIG in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes Aats-tyrE196K.Scer\UAS in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes Aats-tyrG41R.Scer\UAS in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes Aats-tyrK264N.Scer\UAS in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes Aats-tyrNIG.4561R in vitro construct - RNAi 0 -- Aats-tyrScer\UAS.cSa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)Exel6129 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11353} NA P{KK100551} NA P{UAS-Aats-tyr.K264N} NA P{UAS-Aats-tyr.RNAi} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 5 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function
CV term Evidence References
tyrosine-tRNA ligase activity inferred from direct assay (Storkebaum et al., 2009)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR002305, InterPro:IPR002307 (FlyBase Curators et al., 2004-) tRNA binding inferred from electronic annotation with InterPro:IPR002547 (FlyBase Curators et al., 2004-) tyrosine-tRNA ligase activity inferred from sequence or structural similarity with NCBI_gi:4507947 AND non-traceable author statement (FlyBase, 1992-)
Biological Process
CV term Evidence References
tyrosyl-tRNA aminoacylation inferred from electronic annotation with InterPro:IPR002307 (FlyBase Curators et al., 2004-) non-traceable author statement (FlyBase, 1992-)
Cellular Component
CV term Evidence References
cytoplasm inferred from electronic annotation with InterPro:IPR002305, InterPro:IPR002307 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Aats-tyr - clu anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Aats-tyr - eIF-4B experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Aats-tyr allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 65135 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0027080 DroID - A comprehensive database of gene and protein interactions. • FBgn0027080 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39829
Orthologs
OrthoDB Orthologs (41) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6XPR1M Dipteran inclusive ortholog search EOG6G1MQQ Insect inclusive ortholog search EOG6BRVFZ Arthropod inclusive ortholog search EOG6G4F5N Metazoa inclusive ortholog search EOG67Q905
Orthologs in Drosophila Species (EOG6XPR1M)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Aats-tyr     Drosophila simulans   Dsim\GD12469 Y   Drosophila sechellia   Dsec\GM24400 Y   Drosophila erecta   Dere\GG13450 Y   Drosophila yakuba   Dyak\GE22999     Drosophila yakuba   Dyak\GE22552 Y   Drosophila ananassae   Dana\GF10209 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA18259 Y   Drosophila persimilis   Dper\GL17993 Y   Drosophila willistoni   Dwil\GK17487 Y   Drosophila virilis   Dvir\Aats-tyr Y   Drosophila mojavensis   Dmoj\GI16545 Y   Drosophila grimshawi   Dgri\GH15893 Y
Orthologs in non-Drosophila Dipterans (EOG6G1MQQ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL001044   Anopheles gambiae Malaria mosquito  Agam\AGAP003003   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ007229
Orthologs in non-Dipteran Insects (EOG6BRVFZ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\Aats-tyr   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG007699   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH11169   Atta cephalotes Leafcutter ant  Acep\ACEP18296   Camponotus floridanus Florida carpenter ant  Cflo\CFLO15347   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL18791   Linepithema humile Argentine ant  Lhum\LH16191   Pogonomyrmex barbatus Red harvester ant  Pbar\PB17002   Solenopsis invicta Red fire ant  Sinv\SINV13092   Acyrthosiphon pisum Pea aphid  Apim\ACYPI004940   Acyrthosiphon pisum Pea aphid  Apim\ACYPI53903   Bombyx mori Silkmoth  Bmor\BGIBMGA001525   Pediculus humanus Human body louse  Phum\PHUM584030   Tribolium castaneum Red flour beetle  Tcas\TC013181
Orthologs in non-Insect Arthropods (EOG6G4F5N)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\rpoB   Ixodes scapularis Deer tick  Isca\ISCW001421
Orthologs in non-Arthropod Metazoa (EOG67Q905)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\yrs-2   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_016421gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_007595gn   Danio rerio Zebrafish  Drer\ENSDARG00000035913   Xenopus tropicalis Western clawed frog  Xtro\yars   Gallus gallus Domestic chicken  Ggal\YARS   Mus musculus House mouse  Mmus\Yars   Rattus norvegicus Norway rat  Rnor\Yars   Homo sapiens Human  Hsap\YARS
Human Orthologs (1)
Gene OMIM HGNC Hsap\YARS
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD12469 Drosophila sechellia Dsec\GM24400 Drosophila erecta Dere\GG13450 Drosophila yakuba Dyak\GE22552 Drosophila ananassae Dana\GF10209 Drosophila pseudoobscura pseudoobscura Dpse\GA18259 Drosophila persimilis Dper\GL17993 Drosophila willistoni Dwil\GK17487 Drosophila virilis Dvir\Aats-tyr Drosophila mojavensis Dmoj\GI16545 Drosophila grimshawi Dgri\GH15893
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
VDRC	v105615 P{KK100551}VIE-260B v40541 w1118; P{GD11353}v40541/TM3
Genomic Clones ( 1 )
	BACR09I16 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 146 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD21116
Other clones	DPiM_LD21116
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT07521 AT12079 AT18612 AT18726 GH03606 GH20011 GH21743 GM05154 GM05448 GM06639 GM09071 GM12333 GM17240 GM18607 LD07937 LD11402 LD11886 LD27229 LD36136 LD37632 LD37954 LD38307 LD39873 LD40592 LD43635 LP05943 RE03111 RE08304 RE12222 RE22354 RE30640 RE30680 RE32229 RE42019 RE45083 RE48183 RE50183 RE59024 RH10852 RH13837 RH17604 RH26951 RH38920 RH40522 RH58177 RH62261 RH63230 SD06511 SD06816 SD08402 SD11728 SD12738 SD12833 SD13205 SD13418 SD17062 SD18146 SD18663 SD19029 SD21839 SD22555 SD25284 SD27952
Other clones	694 72048 106089 125644 CK01.34A.F5 CK01.110C.G1 Dmel_neb_004399_0937_3596 Dmel_neb_011414_0842_3063 EC38990 EK100919 EK121517 EK200330 EK247716 EP09707 FGA001C01 FGM102E11 FGM211H05 FGM223C10 FGM324F07 LD27125 RH09208 RP003012685 RP003073056 RP003085734 RP003099849 RP003116137 RP003118916 RP003122790 RP003143534 RP003153124 RP003158158 RP003168768 RP003174481 RP003176029 RP003177963 RP003180662 RP003180769 RP003197007 RP003205591 RP003208288 RP003213599 RP003221322 RP003222399 RP003222425 RP003224887 RP003232206 RP003234529 RP003246675 RP003259858 RP003260094 RP003260801 RP003267091 RP003268305 RP003274016 RP003275228 RP003293268 RP003302125 RP003323629 RP003326220 RP003345728 RP003345886 RP003347784 RP003349141 RP003350619 RP003356219 RP003359731 RP003368106 RP003422371 RP003427008 RP003427444 RP003442331 RP003489848 RP003501418 RP003505124 RP003518706 RP003562377 RP003568821 RP003571906 RP003622153 RP003657384 UUGC0638
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0027080 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39829
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Aats-tyr CG4561 (FlyBase, 1996-) Source for merge of: CG4561 anon-EST:Posey261 (Bayraktaroglu, 2000.11.2)
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_140638 RefSeq (Proteins) • NP_648895 DDBJ / EMBL / GenBank • AA697091 AA735326 AAF49462 AAK93086 AF083316 AI455095 AY051662 Entrez Gene - A searchable database of RefSeq genes. • 39829 UniProtKB/TrEMBL • Q9VV60
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Aminoacyl-tRNA synthetase, class Ic (IPR002305) Tyrosine-tRNA ligase (IPR002307) tRNA-binding domain (IPR002547) Nucleic acid-binding, OB-fold (IPR012340) Tyrosine-tRNA ligase, archaeal/eukaryotic-type (IPR023617) Rossmann-like alpha/beta/alpha sandwich fold (IPR014729) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD21116
Linkouts
	BioGRID - A database of protein and genetic interactions • 65135 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0027080 DroID - A comprehensive database of gene and protein interactions. • FBgn0027080 DRSC - Results from RNAi screens. • FBgn0027080 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0027080 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4561-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0027080 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39829 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39829 modMine - Data generated by the modENCODE project. • FBgn0027080
Synonyms & Secondary IDs ( 9 )
Reported As
Symbol Synonym	Aats-tyr (Pierce et al., 2008, Storkebaum et al., 2009, Conant and Wagner, 2005, Parry et al., 2010) anon-EST:Posey261   CG4561 (Gong et al., 2004, Pile et al., 2003, Giot et al., 2003, Keleman et al., 2009.8.5) dYARS (Storkebaum et al., 2009, Leitao-Goncalves et al., 2012) TyrRS (Seshaiah and Andrew, 1999.7.29, Leitao-Goncalves et al., 2012) YARS (Leitao-Goncalves et al., 2012) YRS (Seshaiah and Andrew, 1999)
Name Synonym	Tyrosyl-tRNA synthetase (Seshaiah and Andrew, 1999) tyrosyl-tRNA synthetase (Leitao-Goncalves et al., 2012)
Secondary FlyBase IDs
	FBgn0025537 FBgn0036630
References ( 28 )
Generate a list of	All references relating to this gene ( 28 )
List References by type	Research paper  ( 10 ) Supplementary material  ( 5 ) Personal communication to FlyBase  ( 8 ) FlyBase analysis  ( 2 ) Website  ( 1 ) Curated genome annotation  ( 1 ) DNA/RNA sequence record  ( 1 )
Recent research papers ( 1 )
	Leitao-Goncalves et al., 2012, Amino Acids 42(5): 1661--1668 Drosophila as a platform to predict the pathogenicity of novel aminoacyl-tRNA synthetase mutations in CMT. [FBrf0218080] Show all research papers ...