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Gene Dmel\Aats-ile

General Information
Symbol	Dmel\Aats-ile	Species	D. melanogaster
Name	Isoleucyl-tRNA synthetase	Annotation symbol	CG11471
Feature type	protein_coding_gene	FlyBase ID	FBgn0027086
Gene Model Status	Current	Stock availability	4 publicly available
Also Known As	l(3)00827
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	79D4-79D4	Sequence location	3L:22,281,765..22,285,910 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Isoleucyl-tRNA synthetase is referred to in FlyBase by the symbol Dmel\Aats-ile (CG11471, FBgn0027086). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: isoleucine-tRNA ligase activity. Based on sequence similarity, it is predicted to be involved in the biological process: isoleucyl-tRNA aminoacylation. 10 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Aminoacyl-tRNA synthetase, class 1a, anticodon-binding; Aminoacyl-tRNA synthetase, class I, conserved site; Aminoacyl-tRNA synthetase, class Ia; Isoleucine-tRNA ligase; Isoleucine-tRNA ligase, type 2; Rossmann-like alpha/beta/alpha sandwich fold; Valyl/Leucyl/Isoleucyl-tRNA synthetase, class I, anticodon-binding; Valyl/Leucyl/Isoleucyl-tRNA synthetase, class Ia, editing domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, larval/adult salivary gland, larval trachea, adult ovary, adult male accessory gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, adult spermathecae, adult testis, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1631106_s_at completely aligns to an exonic region common to each of the 3 FlyBase-annotated transcript isoforms of Aats-ile. Gene sequence location is 3L:22281765..22285910.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 79D4-79D4   Limits computationally determined from genome sequence between P{lacW}l(3)j1B10j1B10 and P{lacW}l(3)j2C4j2C4
Experimentally Determined Cytological Location
Cytogenetic map Notes References 79E1-79E2   (determined by in situ hybridisation)   (Spradling et al., 1999) 79E1-79E2   (determined by in situ hybridisation)   (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Aats-ile for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.44 Gene model reviewed during 5.45
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Aats-ile-RA FBtr0078498  NM_168952   3899   1229 Aats-ile-RC FBtr0078499  NM_080101   3820   1229 Aats-ile-RD FBtr0078500  NM_176387   3845   1229
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Aats-ile-PA   FBpp0078150   141.1   1229   7.56     NP_730716   AAF51822 Aats-ile-PC   FBpp0078151   141.1   1229   7.56     NP_524840   AAF51823 Aats-ile-PD   FBpp0078152   141.1   1229   7.56     NP_788565   AAO41285
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Aminoacyl-tRNA synthetase, class I, conserved site (IPR001412) Aminoacyl-tRNA synthetase, class Ia (IPR002300) Isoleucine-tRNA ligase (IPR002301) Valyl/Leucyl/Isoleucyl-tRNA synthetase, class Ia, editing domain (IPR009008) Aminoacyl-tRNA synthetase, class 1a, anticodon-binding (IPR009080) Valyl/Leucyl/Isoleucyl-tRNA synthetase, class I, anticodon-binding (IPR013155) Isoleucine-tRNA ligase, type 2 (IPR023586) Rossmann-like alpha/beta/alpha sandwich fold (IPR014729)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141753   AA141754   AA201809   AA202938   AA263618   AA391628   AA391924   AA392674   AA695742   AA941855   AA942260   AA948929   AA949364   AA950315   AA951561   AA952170   AA979051   AA979203   AE014296 AAF51822   AE014296 AAF51823   AE014296 AAO41285   AI239204   AI455711   AI456284   AI456652   AI513944   AI514761   AI516155   AI518279   AI518381   AI519844   AI520131   AI531720   AI533506   AI534210   AI534332   AI534413   AI541600   AI546552   AQ026160   AW942740   AY118538 AAM49907   BF500798   BG635427   BG635590   BG638320   BG638337   BG638553   BG638760   BG640220   BG640866   BI163238   BI164013   BI173357   BI214211   BI214401   BI229158   BI233307   BI237210   BI239290   BI239332   BI352361   BI352950   BI355521   BI356590   BI362015   BI370284   BI370324   BI371045   BI371684   BI376145   BI483057   BI483162   BI483751   BI483890   BI485270   BI485293   BI486949   BI580724   BI632975   BI636880   BI637091   CK132404   CK132417   CK658968   CL632139   CO187551   CO277410   CO307008   CO332122   CZ484204   EC060271   EC069116   EC075225   EC201027   EC239714   EC249354   EV584913   FD585486   FD585852   FD586215   FD586587   FD586948   FD587078   GH738804   GH738853   GH738878   GH739013   GH739161   GH739261   GH739460   GH739470   GH739520   GH739553   GH739589   GH739598   GH739766   GH739774   GH739848   GH740029   GH740085   GH740097   GH740337   GH740350   GH740432   GH740486   GH741056   GH741108   GH741282   GH741285   GH741412   GH741612   GH741614   GH741710   GH741839   GH741840   GH742046   GH742065   GH742164   GH742295   GH742334   GH742380   GH742402   GH742425   GH742692   GH742703   GH742748   GH742762   GH742771   GH742873   GH742900   GH742903   GH743012   GH743029   GH743425   GH743492   GH743504   GH743576   GH743653   GH743681   GH743686   GH743719   GH743738   GH743762   GH743796   GH743941   GH743996   GH744019   GH744060   GH744219   GH744344   GH744451   GH744566   GH744586   GH744646   GH744697   GH744736   GH744767   GH744798   GH744988   GH745029   GH745137   GH745138   GH745172   GH745178   GH745298   GH745387   GH745430   GH745567   GH745591   GH745849   GH745888   GH746223   GH746237   GH746281   GH746441   GH746472   GH746509   GH746557   GH746656   GH746668   GH746728   GH746732   GH746781   GH746946   GH747006   GH747007   GH747049   GH747114   GH747129   GH747268   GH747440   GH747460   GH761846   GH761856   GH761944   GH761955   GH762041   GH762082   GH762188   GH762337   GH762420   GH762761   GH762946   GH763329   GH763343   GH763357   GH763429   GH763498   GH763614   GH763668   GH763790   GH763817   GH763898   GH764008   GH764032   GH764111   GH764264   GH764328   GH764405   GH764507   GH764519   GH764579   GH764590   GH764594   GH764602   GH764696   GH765010   GH765039   GH765046   GH765095   GH765213   GH765320   GH765332   GH765464   GH765599   GH765636   GH765791   GH765870   GH766000   GH766012   GH766127   GH766188   GH766201   GH766243   GH766246   GH766316   GH766328   GH766391   GH766411   GH766493   GH766824   GH766855   GH766902   GH767008   GH767041   GH767067   GH767127   GH767193   GH767205   GH767519   GH767564   GH767827   GH768009   GH768064   GH768128   GH768133   GH768306   GH768343   GH768460   GH768782   GH768880   GH768912   GH768965   GH769070   GH769148   GH769200   GH769291   GH769453   GH769472   GH769597   GH769608   GH769614   GH769689   GH769788   GH769809   GH769871   GH769920   GH770017   GH770064   GH770104   GH779211   GH779776   GO254417   GO254444   GO254445   GO254464   GO254471   GO254493   GO254520   GO254572
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8MSW0
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage   organism | ubiquitous   (Seshaiah and Andrew, 1999) embryonic/larval salivary gland   (Seshaiah and Andrew, 1999) embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   head mesoderm   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) embryonic stage 9 -- 10   anterior endoderm   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) embryonic stage 11 -- 12   anal pad primordium   (Fisher et al., 2012) Comment:reported as anal pad specific anlage anterior midgut primordium   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) hindgut proper primordium   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) posterior midgut primordium   (Fisher et al., 2012) salivary gland body primordium   (Fisher et al., 2012) somatic muscle primordium   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) visceral muscle primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic anal pad   (Fisher et al., 2012) embryonic hindgut   (Fisher et al., 2012) embryonic large intestine   (Fisher et al., 2012) embryonic/larval midgut   (Fisher et al., 2012) embryonic/larval muscle system   (Fisher et al., 2012) embryonic/larval salivary gland   (Fisher et al., 2012) embryonic/larval salivary gland body   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012)
Additional Descriptive Data
	Aats-ile transcripts are at a transiently elevated level in the embryonic salivary gland that persists from ~embryonic stage 11-12. (Seshaiah and Andrew, 1999)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, larval/adult salivary gland, larval trachea, adult ovary, adult male accessory gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, adult spermathecae, adult testis, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    503.625 Larval Midgut    234 Larval Hindgut    404.7 Larval Malpighian Tubules    193.1 Larval Fat Body    202.2 Larval Salivary Gland    1009.1 Larval Trachea    560.05 Larval Carcass    475.4 Adult Head    237.9 Adult Eye    271.1 Adult Brain    161.9 Adult Thoracic-Abdominal Ganglion    191.3 Adult Crop    380 Adult Midgut    305.9 Adult Hindgut    289.8 Adult Malpighian Tubules    298.1 Adult Fat Body    422.7 Adult Salivary Gland    716.3 Adult Heart    261.9 Adult VirginFemale Spermatheca    269.6 Adult InseminatedFemale Spermatheca    347.1 Adult Ovary    589.2 Adult Testis    108.6 Adult Male Accessory Gland    815 Adult Carcass    245.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  503.625 Larval Midgut    234 Larval Hindgut    404.7 Larval Malpighian Tubules    193.1 Larval Fat Body    202.2 Larval Salivary Gland  (1009.1) Larval Trachea  (560.05) Larval Carcass    475.4 Adult Head    237.9 Adult Eye    271.1 Adult Brain    161.9 Adult Thoracic-Abdominal Ganglion    191.3 Adult Crop    380 Adult Midgut    305.9 Adult Hindgut    289.8 Adult Malpighian Tubules    298.1 Adult Fat Body    422.7 Adult Salivary Gland  (716.3) Adult Heart    261.9 Adult VirginFemale Spermatheca    269.6 Adult InseminatedFemale Spermatheca    347.1 Adult Ovary  (589.2) Adult Testis    108.6 Adult Male Accessory Gland  (815) Adult Carcass    245.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    503.625 Larval Midgut    234 Larval Hindgut    404.7 Larval Malpighian Tubules    193.1 Larval Fat Body    202.2 Larval Salivary Gland  1009.1 Larval Trachea    560.05 Larval Carcass    475.4 Adult Head    237.9 Adult Eye    271.1 Adult Brain    161.9 Adult Thoracic-Abdominal Ganglion    191.3 Adult Crop    380 Adult Midgut    305.9 Adult Hindgut    289.8 Adult Malpighian Tubules    298.1 Adult Fat Body    422.7 Adult Salivary Gland    716.3 Adult Heart    261.9 Adult VirginFemale Spermatheca    269.6 Adult InseminatedFemale Spermatheca    347.1 Adult Ovary    589.2 Adult Testis    108.6 Adult Male Accessory Gland    815 Adult Carcass    245.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    503.625 Larval Midgut    234 Larval Hindgut    404.7 Larval Malpighian Tubules    193.1 Larval Fat Body    202.2 Larval Salivary Gland    1009.1 Larval Trachea    560.05 Larval Carcass    475.4 Adult Head    237.9 Adult Eye    271.1 Adult Brain    161.9 Adult Thoracic-Abdominal Ganglion    191.3 Adult Crop    380 Adult Midgut    305.9 Adult Hindgut    289.8 Adult Malpighian Tubules    298.1 Adult Fat Body    422.7 Adult Salivary Gland    716.3 Adult Heart    261.9 Adult VirginFemale Spermatheca    269.6 Adult InseminatedFemale Spermatheca    347.1 Adult Ovary    589.2 Adult Testis    108.6 Adult Male Accessory Gland    815 Adult Carcass    245.9 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    503.625 Larval Midgut    234 Larval Hindgut    404.7 Larval Malpighian Tubules    193.1 Larval Fat Body    202.2 Larval Salivary Gland    1009.1 Larval Trachea    560.05 Larval Carcass    475.4 Adult Head    237.9 Adult Eye    271.1 Adult Brain    161.9 Adult Thoracic-Abdominal Ganglion    191.3 Adult Crop    380 Adult Midgut    305.9 Adult Hindgut    289.8 Adult Malpighian Tubules    298.1 Adult Fat Body    422.7 Adult Salivary Gland    716.3 Adult Heart    261.9 Adult VirginFemale Spermatheca    269.6 Adult InseminatedFemale Spermatheca    347.1 Adult Ovary    589.2 Adult Testis    108.6 Adult Male Accessory Gland    815 Adult Carcass    245.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  503.625 Larval Midgut    234 Larval Hindgut    404.7 Larval Malpighian Tubules    193.1 Larval Fat Body    202.2 Larval Salivary Gland  (1009.1) Larval Trachea  560.05 Larval Carcass    475.4 Adult Head    237.9 Adult Eye    271.1 Adult Brain    161.9 Adult Thoracic-Abdominal Ganglion    191.3 Adult Crop    380 Adult Midgut    305.9 Adult Hindgut    289.8 Adult Malpighian Tubules    298.1 Adult Fat Body    422.7 Adult Salivary Gland  716.3 Adult Heart    261.9 Adult VirginFemale Spermatheca    269.6 Adult InseminatedFemale Spermatheca    347.1 Adult Ovary  589.2 Adult Testis    108.6 Adult Male Accessory Gland  (815) Adult Carcass    245.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    503.625 Larval Midgut    234 Larval Hindgut    404.7 Larval Malpighian Tubules    193.1 Larval Fat Body    202.2 Larval Salivary Gland  1009.1 Larval Trachea    560.05 Larval Carcass    475.4 Adult Head    237.9 Adult Eye    271.1 Adult Brain    161.9 Adult Thoracic-Abdominal Ganglion    191.3 Adult Crop    380 Adult Midgut    305.9 Adult Hindgut    289.8 Adult Malpighian Tubules    298.1 Adult Fat Body    422.7 Adult Salivary Gland    716.3 Adult Heart    261.9 Adult VirginFemale Spermatheca    269.6 Adult InseminatedFemale Spermatheca    347.1 Adult Ovary    589.2 Adult Testis    108.6 Adult Male Accessory Gland    815 Adult Carcass    245.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    503.625 Larval Midgut    234 Larval Hindgut    404.7 Larval Malpighian Tubules    193.1 Larval Fat Body    202.2 Larval Salivary Gland    1009.1 Larval Trachea    560.05 Larval Carcass    475.4 Adult Head    237.9 Adult Eye    271.1 Adult Brain    161.9 Adult Thoracic-Abdominal Ganglion    191.3 Adult Crop    380 Adult Midgut    305.9 Adult Hindgut    289.8 Adult Malpighian Tubules    298.1 Adult Fat Body    422.7 Adult Salivary Gland    716.3 Adult Heart    261.9 Adult VirginFemale Spermatheca    269.6 Adult InseminatedFemale Spermatheca    347.1 Adult Ovary    589.2 Adult Testis    108.6 Adult Male Accessory Gland    815 Adult Carcass    245.9 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    237.9   NA  Eye    271.1   NA  Brain    161.9   503.625  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    191.3   NA  Crop    380   234  Midgut    305.9   404.7  Hindgut    289.8   193.1  Malpighian Tubules    298.1   202.2  Fat Body    422.7   1009.1  Salivary Gland    716.3   NA  Heart    261.9   560.05  Trachea    NA   NA  VirginFemale Spermatheca    269.6   NA  InseminatedFemale Spermatheca    347.1   NA  Ovary    589.2   NA  Testis    108.6   NA  Male Accessory Gland    815   475.4  Carcass    245.9 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3    18 central nervous system, pupae P8    13 head, virgin 1-day female    12 head, virgin 4-day female    10 head, virgin 20-day female    12 head, mated 1-day female    7 head, mated 4-day female    15 head, mated 20-day female    8 head, mated 1-day male    7 head, mated 4-day male    14 head, mated 20-day male    16 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    10 digestive system, 4-day adult    15 digestive system, 20-day adult    11 fat body, larvae L3 wandering    4 fat body, white prepupae    6 fat body, pupae P8    9 carcass, larvae L3 wandering    18 carcass, 1-day adult    8 carcass, 4-day adult    17 carcass, 20-day adult    9 ovary, virgin 4-day female    64 ovary, mated 4-day female    46 testis, mated 4-day male    7 accessory gland, mated 4-day male    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3    18 central nervous system, pupae P8    13 head, virgin 1-day female    12 head, virgin 4-day female    10 head, virgin 20-day female    12 head, mated 1-day female    7 head, mated 4-day female    15 head, mated 20-day female    8 head, mated 1-day male    7 head, mated 4-day male    14 head, mated 20-day male    16 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    10 digestive system, 4-day adult    15 digestive system, 20-day adult    11 fat body, larvae L3 wandering    4 fat body, white prepupae    6 fat body, pupae P8    9 carcass, larvae L3 wandering    18 carcass, 1-day adult    8 carcass, 4-day adult    17 carcass, 20-day adult    9 ovary, virgin 4-day female  (64) ovary, mated 4-day female  (46) testis, mated 4-day male    7 accessory gland, mated 4-day male    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3    18 central nervous system, pupae P8    13 head, virgin 1-day female    12 head, virgin 4-day female    10 head, virgin 20-day female    12 head, mated 1-day female    7 head, mated 4-day female    15 head, mated 20-day female    8 head, mated 1-day male    7 head, mated 4-day male    14 head, mated 20-day male    16 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    10 digestive system, 4-day adult    15 digestive system, 20-day adult    11 fat body, larvae L3 wandering    4 fat body, white prepupae    6 fat body, pupae P8    9 carcass, larvae L3 wandering    18 carcass, 1-day adult    8 carcass, 4-day adult    17 carcass, 20-day adult    9 ovary, virgin 4-day female    64 ovary, mated 4-day female    46 testis, mated 4-day male    7 accessory gland, mated 4-day male    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3    18 central nervous system, pupae P8    13 head, virgin 1-day female    12 head, virgin 4-day female    10 head, virgin 20-day female    12 head, mated 1-day female    7 head, mated 4-day female    15 head, mated 20-day female    8 head, mated 1-day male    7 head, mated 4-day male    14 head, mated 20-day male    16 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    10 digestive system, 4-day adult    15 digestive system, 20-day adult    11 fat body, larvae L3 wandering    4 fat body, white prepupae    6 fat body, pupae P8    9 carcass, larvae L3 wandering    18 carcass, 1-day adult    8 carcass, 4-day adult    17 carcass, 20-day adult    9 ovary, virgin 4-day female    64 ovary, mated 4-day female    46 testis, mated 4-day male    7 accessory gland, mated 4-day male    13 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3    18 central nervous system, pupae P8    13 head, virgin 1-day female    12 head, virgin 4-day female    10 head, virgin 20-day female    12 head, mated 1-day female    7 head, mated 4-day female    15 head, mated 20-day female    8 head, mated 1-day male    7 head, mated 4-day male    14 head, mated 20-day male    16 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    10 digestive system, 4-day adult    15 digestive system, 20-day adult    11 fat body, larvae L3 wandering    4 fat body, white prepupae    6 fat body, pupae P8    9 carcass, larvae L3 wandering    18 carcass, 1-day adult    8 carcass, 4-day adult    17 carcass, 20-day adult    9 ovary, virgin 4-day female    64 ovary, mated 4-day female    46 testis, mated 4-day male    7 accessory gland, mated 4-day male    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3    18 central nervous system, pupae P8    13 head, virgin 1-day female    12 head, virgin 4-day female    10 head, virgin 20-day female    12 head, mated 1-day female    7 head, mated 4-day female    15 head, mated 20-day female    8 head, mated 1-day male    7 head, mated 4-day male    14 head, mated 20-day male    16 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    10 digestive system, 4-day adult    15 digestive system, 20-day adult    11 fat body, larvae L3 wandering    4 fat body, white prepupae    6 fat body, pupae P8    9 carcass, larvae L3 wandering    18 carcass, 1-day adult    8 carcass, 4-day adult    17 carcass, 20-day adult    9 ovary, virgin 4-day female  (64) ovary, mated 4-day female  (46) testis, mated 4-day male    7 accessory gland, mated 4-day male    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3    18 central nervous system, pupae P8    13 head, virgin 1-day female    12 head, virgin 4-day female    10 head, virgin 20-day female    12 head, mated 1-day female    7 head, mated 4-day female    15 head, mated 20-day female    8 head, mated 1-day male    7 head, mated 4-day male    14 head, mated 20-day male    16 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    10 digestive system, 4-day adult    15 digestive system, 20-day adult    11 fat body, larvae L3 wandering    4 fat body, white prepupae    6 fat body, pupae P8    9 carcass, larvae L3 wandering    18 carcass, 1-day adult    8 carcass, 4-day adult    17 carcass, 20-day adult    9 ovary, virgin 4-day female    64 ovary, mated 4-day female    46 testis, mated 4-day male    7 accessory gland, mated 4-day male    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3    18 central nervous system, pupae P8    13 head, virgin 1-day female    12 head, virgin 4-day female    10 head, virgin 20-day female    12 head, mated 1-day female    7 head, mated 4-day female    15 head, mated 20-day female    8 head, mated 1-day male    7 head, mated 4-day male    14 head, mated 20-day male    16 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    10 digestive system, 4-day adult    15 digestive system, 20-day adult    11 fat body, larvae L3 wandering    4 fat body, white prepupae    6 fat body, pupae P8    9 carcass, larvae L3 wandering    18 carcass, 1-day adult    8 carcass, 4-day adult    17 carcass, 20-day adult    9 ovary, virgin 4-day female    64 ovary, mated 4-day female    46 testis, mated 4-day male    7 accessory gland, mated 4-day male    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    63 embryo 02-04hr    86 embryo 04-06hr    45 embryo 06-08hr    36 embryo 08-10hr    46 embryo 10-12hr    36 embryo 12-14hr    48 embryo 14-16hr    36 embryo 16-18hr    34 embryo 18-20hr    17 embryo 20-22hr    30 embryo 22-24hr    38 larva L1    47 larva L2    49 larva L3 12hr old    36 larva L3 puffstage 1-2    18 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    25 white prepupae new    23 white prepupae 12hr    18 white prepupae 24hr    21 pupae 2d postWPP    27 pupae 3d postWPP    19 pupae 4d postWPP    11 adult male 01day    15 adult male 05day    14 adult male 30day    13 adult female 01day    40 adult female 05day    67 adult female 30day    60 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (63) embryo 02-04hr  (86) embryo 04-06hr  (45) embryo 06-08hr  (36) embryo 08-10hr  (46) embryo 10-12hr  (36) embryo 12-14hr  (48) embryo 14-16hr  (36) embryo 16-18hr  (34) embryo 18-20hr    17 embryo 20-22hr  (30) embryo 22-24hr  (38) larva L1  (47) larva L2  (49) larva L3 12hr old  (36) larva L3 puffstage 1-2    18 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    25 white prepupae new    23 white prepupae 12hr    18 white prepupae 24hr    21 pupae 2d postWPP  (27) pupae 3d postWPP    19 pupae 4d postWPP    11 adult male 01day    15 adult male 05day    14 adult male 30day    13 adult female 01day  (40) adult female 05day  (67) adult female 30day  (60) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    63 embryo 02-04hr    86 embryo 04-06hr    45 embryo 06-08hr    36 embryo 08-10hr    46 embryo 10-12hr    36 embryo 12-14hr    48 embryo 14-16hr    36 embryo 16-18hr    34 embryo 18-20hr    17 embryo 20-22hr    30 embryo 22-24hr    38 larva L1    47 larva L2    49 larva L3 12hr old    36 larva L3 puffstage 1-2    18 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    25 white prepupae new    23 white prepupae 12hr    18 white prepupae 24hr    21 pupae 2d postWPP    27 pupae 3d postWPP    19 pupae 4d postWPP    11 adult male 01day    15 adult male 05day    14 adult male 30day    13 adult female 01day    40 adult female 05day    67 adult female 30day    60 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    63 embryo 02-04hr    86 embryo 04-06hr    45 embryo 06-08hr    36 embryo 08-10hr    46 embryo 10-12hr    36 embryo 12-14hr    48 embryo 14-16hr    36 embryo 16-18hr    34 embryo 18-20hr    17 embryo 20-22hr    30 embryo 22-24hr    38 larva L1    47 larva L2    49 larva L3 12hr old    36 larva L3 puffstage 1-2    18 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    25 white prepupae new    23 white prepupae 12hr    18 white prepupae 24hr    21 pupae 2d postWPP    27 pupae 3d postWPP    19 pupae 4d postWPP    11 adult male 01day    15 adult male 05day    14 adult male 30day    13 adult female 01day    40 adult female 05day    67 adult female 30day    60 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    63 embryo 02-04hr    86 embryo 04-06hr    45 embryo 06-08hr    36 embryo 08-10hr    46 embryo 10-12hr    36 embryo 12-14hr    48 embryo 14-16hr    36 embryo 16-18hr    34 embryo 18-20hr    17 embryo 20-22hr    30 embryo 22-24hr    38 larva L1    47 larva L2    49 larva L3 12hr old    36 larva L3 puffstage 1-2    18 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    25 white prepupae new    23 white prepupae 12hr    18 white prepupae 24hr    21 pupae 2d postWPP    27 pupae 3d postWPP    19 pupae 4d postWPP    11 adult male 01day    15 adult male 05day    14 adult male 30day    13 adult female 01day    40 adult female 05day    67 adult female 30day    60 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (63) embryo 02-04hr  (86) embryo 04-06hr  (45) embryo 06-08hr  (36) embryo 08-10hr  (46) embryo 10-12hr  (36) embryo 12-14hr  (48) embryo 14-16hr  (36) embryo 16-18hr  (34) embryo 18-20hr    17 embryo 20-22hr  30 embryo 22-24hr  (38) larva L1  (47) larva L2  (49) larva L3 12hr old  (36) larva L3 puffstage 1-2    18 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    25 white prepupae new    23 white prepupae 12hr    18 white prepupae 24hr    21 pupae 2d postWPP  27 pupae 3d postWPP    19 pupae 4d postWPP    11 adult male 01day    15 adult male 05day    14 adult male 30day    13 adult female 01day  (40) adult female 05day  (67) adult female 30day  (60) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    63 embryo 02-04hr    86 embryo 04-06hr    45 embryo 06-08hr    36 embryo 08-10hr    46 embryo 10-12hr    36 embryo 12-14hr    48 embryo 14-16hr    36 embryo 16-18hr    34 embryo 18-20hr    17 embryo 20-22hr    30 embryo 22-24hr    38 larva L1    47 larva L2    49 larva L3 12hr old    36 larva L3 puffstage 1-2    18 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    25 white prepupae new    23 white prepupae 12hr    18 white prepupae 24hr    21 pupae 2d postWPP    27 pupae 3d postWPP    19 pupae 4d postWPP    11 adult male 01day    15 adult male 05day    14 adult male 30day    13 adult female 01day    40 adult female 05day    67 adult female 30day    60 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    63 embryo 02-04hr    86 embryo 04-06hr    45 embryo 06-08hr    36 embryo 08-10hr    46 embryo 10-12hr    36 embryo 12-14hr    48 embryo 14-16hr    36 embryo 16-18hr    34 embryo 18-20hr    17 embryo 20-22hr    30 embryo 22-24hr    38 larva L1    47 larva L2    49 larva L3 12hr old    36 larva L3 puffstage 1-2    18 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    25 white prepupae new    23 white prepupae 12hr    18 white prepupae 24hr    21 pupae 2d postWPP    27 pupae 3d postWPP    19 pupae 4d postWPP    11 adult male 01day    15 adult male 05day    14 adult male 30day    13 adult female 01day    40 adult female 05day    67 adult female 30day    60 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    84 Schneider line 2 Sg4    44 embryonic 1182-4H    31 embryonic GM2    186 embryonic Kc167    95 embryonic S1    54 embryonic S3    73 leg disc CME L1    47 wing disc CME-W2    148 wing disc ML-DmD8    32 wing disc ML-DmD9    35 wing disc ML-DmD16-c3    30 wing disc ML-DmD21    18 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3    88 eye-antennal disc ML-DmD11    38 antennal disc ML-DmD20-c5    47 mixed discs ML-DmD4-c1    30 CNS ML-DmBG1-c1    58 CNS ML-DmBG2-c2    139 tumorous blood cells mbn2    102 ovary fGS/OSS    39 ovary OSC    45 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (84) Schneider line 2 Sg4  (44) embryonic 1182-4H  (31) embryonic GM2  (186) embryonic Kc167  (95) embryonic S1  (54) embryonic S3  (73) leg disc CME L1  (47) wing disc CME-W2  (148) wing disc ML-DmD8  (32) wing disc ML-DmD9  (35) wing disc ML-DmD16-c3  (30) wing disc ML-DmD21    18 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3  (88) eye-antennal disc ML-DmD11  (38) antennal disc ML-DmD20-c5  (47) mixed discs ML-DmD4-c1  (30) CNS ML-DmBG1-c1  (58) CNS ML-DmBG2-c2  (139) tumorous blood cells mbn2  (102) ovary fGS/OSS  (39) ovary OSC  (45) ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    84 Schneider line 2 Sg4    44 embryonic 1182-4H    31 embryonic GM2  (186) embryonic Kc167    95 embryonic S1    54 embryonic S3    73 leg disc CME L1    47 wing disc CME-W2  (148) wing disc ML-DmD8    32 wing disc ML-DmD9    35 wing disc ML-DmD16-c3    30 wing disc ML-DmD21    18 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3    88 eye-antennal disc ML-DmD11    38 antennal disc ML-DmD20-c5    47 mixed discs ML-DmD4-c1    30 CNS ML-DmBG1-c1    58 CNS ML-DmBG2-c2  (139) tumorous blood cells mbn2  102 ovary fGS/OSS    39 ovary OSC    45 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    84 Schneider line 2 Sg4    44 embryonic 1182-4H    31 embryonic GM2    186 embryonic Kc167    95 embryonic S1    54 embryonic S3    73 leg disc CME L1    47 wing disc CME-W2    148 wing disc ML-DmD8    32 wing disc ML-DmD9    35 wing disc ML-DmD16-c3    30 wing disc ML-DmD21    18 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3    88 eye-antennal disc ML-DmD11    38 antennal disc ML-DmD20-c5    47 mixed discs ML-DmD4-c1    30 CNS ML-DmBG1-c1    58 CNS ML-DmBG2-c2    139 tumorous blood cells mbn2    102 ovary fGS/OSS    39 ovary OSC    45 ovary OSS    8 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    84 Schneider line 2 Sg4    44 embryonic 1182-4H    31 embryonic GM2    186 embryonic Kc167    95 embryonic S1    54 embryonic S3    73 leg disc CME L1    47 wing disc CME-W2    148 wing disc ML-DmD8    32 wing disc ML-DmD9    35 wing disc ML-DmD16-c3    30 wing disc ML-DmD21    18 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3    88 eye-antennal disc ML-DmD11    38 antennal disc ML-DmD20-c5    47 mixed discs ML-DmD4-c1    30 CNS ML-DmBG1-c1    58 CNS ML-DmBG2-c2    139 tumorous blood cells mbn2    102 ovary fGS/OSS    39 ovary OSC    45 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (84) Schneider line 2 Sg4  (44) embryonic 1182-4H  31 embryonic GM2  (186) embryonic Kc167  (95) embryonic S1  (54) embryonic S3  (73) leg disc CME L1  (47) wing disc CME-W2  (148) wing disc ML-DmD8  32 wing disc ML-DmD9  (35) wing disc ML-DmD16-c3  30 wing disc ML-DmD21    18 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3  (88) eye-antennal disc ML-DmD11  (38) antennal disc ML-DmD20-c5  (47) mixed discs ML-DmD4-c1  30 CNS ML-DmBG1-c1  (58) CNS ML-DmBG2-c2  (139) tumorous blood cells mbn2  (102) ovary fGS/OSS  (39) ovary OSC  (45) ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    84 Schneider line 2 Sg4    44 embryonic 1182-4H    31 embryonic GM2  (186) embryonic Kc167    95 embryonic S1    54 embryonic S3    73 leg disc CME L1    47 wing disc CME-W2  (148) wing disc ML-DmD8    32 wing disc ML-DmD9    35 wing disc ML-DmD16-c3    30 wing disc ML-DmD21    18 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3    88 eye-antennal disc ML-DmD11    38 antennal disc ML-DmD20-c5    47 mixed discs ML-DmD4-c1    30 CNS ML-DmBG1-c1    58 CNS ML-DmBG2-c2  139 tumorous blood cells mbn2  102 ovary fGS/OSS    39 ovary OSC    45 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    84 Schneider line 2 Sg4    44 embryonic 1182-4H    31 embryonic GM2    186 embryonic Kc167    95 embryonic S1    54 embryonic S3    73 leg disc CME L1    47 wing disc CME-W2    148 wing disc ML-DmD8    32 wing disc ML-DmD9    35 wing disc ML-DmD16-c3    30 wing disc ML-DmD21    18 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3    88 eye-antennal disc ML-DmD11    38 antennal disc ML-DmD20-c5    47 mixed discs ML-DmD4-c1    30 CNS ML-DmBG1-c1    58 CNS ML-DmBG2-c2    139 tumorous blood cells mbn2    102 ovary fGS/OSS    39 ovary OSC    45 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    7 heat shock, 4-day adult    27 Cadmium 50 mM 6 hrs, larvae L3    16 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult    25 Cadmium 100 mM 48 hrs, 4-day adult    38 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    32 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    17 Ethanol 2.5% 3 hrs, larvae L3    38 Ethanol 5% 3 hrs, larvae L3    20 Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3    21 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    29 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    34 Paraquat 10 mM 48 hrs, 4-day adult    38 Rotenone 2 μg 12 hrs, larvae L3    26 Rotenone 8 μg 12 hrs, larvae L3    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    7 heat shock, 4-day adult  (27) Cadmium 50 mM 6 hrs, larvae L3    16 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult    25 Cadmium 100 mM 48 hrs, 4-day adult  (38) Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult  (32) Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    17 Ethanol 2.5% 3 hrs, larvae L3  (38) Ethanol 5% 3 hrs, larvae L3    20 Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3    21 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (29) Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult  (34) Paraquat 10 mM 48 hrs, 4-day adult  (38) Rotenone 2 μg 12 hrs, larvae L3  26 Rotenone 8 μg 12 hrs, larvae L3    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    7 heat shock, 4-day adult    27 Cadmium 50 mM 6 hrs, larvae L3    16 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult    25 Cadmium 100 mM 48 hrs, 4-day adult    38 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    32 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    17 Ethanol 2.5% 3 hrs, larvae L3    38 Ethanol 5% 3 hrs, larvae L3    20 Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3    21 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    29 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    34 Paraquat 10 mM 48 hrs, 4-day adult    38 Rotenone 2 μg 12 hrs, larvae L3    26 Rotenone 8 μg 12 hrs, larvae L3    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    7 heat shock, 4-day adult    27 Cadmium 50 mM 6 hrs, larvae L3    16 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult    25 Cadmium 100 mM 48 hrs, 4-day adult    38 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    32 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    17 Ethanol 2.5% 3 hrs, larvae L3    38 Ethanol 5% 3 hrs, larvae L3    20 Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3    21 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    29 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    34 Paraquat 10 mM 48 hrs, 4-day adult    38 Rotenone 2 μg 12 hrs, larvae L3    26 Rotenone 8 μg 12 hrs, larvae L3    15 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    7 heat shock, 4-day adult    27 Cadmium 50 mM 6 hrs, larvae L3    16 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult    25 Cadmium 100 mM 48 hrs, 4-day adult    38 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    32 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    17 Ethanol 2.5% 3 hrs, larvae L3    38 Ethanol 5% 3 hrs, larvae L3    20 Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3    21 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    29 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    34 Paraquat 10 mM 48 hrs, 4-day adult    38 Rotenone 2 μg 12 hrs, larvae L3    26 Rotenone 8 μg 12 hrs, larvae L3    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    7 heat shock, 4-day adult  27 Cadmium 50 mM 6 hrs, larvae L3    16 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult    25 Cadmium 100 mM 48 hrs, 4-day adult  (38) Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult  32 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    17 Ethanol 2.5% 3 hrs, larvae L3  (38) Ethanol 5% 3 hrs, larvae L3    20 Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3    21 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  29 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult  (34) Paraquat 10 mM 48 hrs, 4-day adult  (38) Rotenone 2 μg 12 hrs, larvae L3  26 Rotenone 8 μg 12 hrs, larvae L3    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    7 heat shock, 4-day adult    27 Cadmium 50 mM 6 hrs, larvae L3    16 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult    25 Cadmium 100 mM 48 hrs, 4-day adult    38 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    32 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    17 Ethanol 2.5% 3 hrs, larvae L3    38 Ethanol 5% 3 hrs, larvae L3    20 Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3    21 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    29 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    34 Paraquat 10 mM 48 hrs, 4-day adult    38 Rotenone 2 μg 12 hrs, larvae L3    26 Rotenone 8 μg 12 hrs, larvae L3    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    7 heat shock, 4-day adult    27 Cadmium 50 mM 6 hrs, larvae L3    16 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult    25 Cadmium 100 mM 48 hrs, 4-day adult    38 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    32 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    17 Ethanol 2.5% 3 hrs, larvae L3    38 Ethanol 5% 3 hrs, larvae L3    20 Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3    21 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    29 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    34 Paraquat 10 mM 48 hrs, 4-day adult    38 Rotenone 2 μg 12 hrs, larvae L3    26 Rotenone 8 μg 12 hrs, larvae L3    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_08 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	BDGP expression data • LD27166 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0027086 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11471-RC FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Aats-ile Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | recessive Aats-ile00827 Aats-ileB44 Aats-ileC19 Aats-ileC62 Other Phenotypes Allele decreased cell number | somatic clone | third instar larval stage Aats-ileB44 Aats-ileC19 Aats-ileC62 Phenotype manifest in Allele embryonic/larval brain | somatic clone | third instar larval stage Aats-ileB44 Aats-ileC19 Aats-ileC62
Classical Alleles ( 8 )
For All Classical Alleles Show
Allele of Aats-ile Class Mutagen Stocks Known lesion Aats-ile00827 P-element activity 1 -- Aats-ileCB-6683-3 1 -- Aats-ileEY03542 P-element activity 1 -- Aats-ilef01737 piggyBac transposase 1 -- Aats-ileB44 ethyl methanesulfonate 0 -- Aats-ileC19 ethyl methanesulfonate 0 -- Aats-ileC62 ethyl methanesulfonate 0 -- Aats-ileDG09701 0 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Aats-ile Class Mutagen Stocks Known lesion Aats-ileGD1341 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Aats-ileNIG.11471R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)BSC420 (Christensen et al., 2008.4.15) Df(3L)BSC451 (Christensen et al., 2008.4.15) Df(3L)Exel6138 (Ryder, 2004.4.26)
Not disrupted in	Df(3L)Pc-MK (Spradling et al., 1999, BDGP Project Members, 1994-1999)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1341} NA P{NIG.11471R} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{PZ}Aats-ile00827 No insertion of mobile activating element P{EPgy2}Aats-ileEY03542 NA miscellaneous insertions P{RS3}Aats-ileCB-6683-3 NA P{wHy}Aats-ileDG09701 NA PBac{WH}Aats-ilef01737 NA
Gene Ontology: Function, Process & Cellular Component ( 5 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
aminoacyl-tRNA editing activity inferred from electronic annotation with InterPro:IPR009008 (FlyBase Curators et al., 2004-) ATP binding inferred from electronic annotation with InterPro:IPR001412, InterPro:IPR002300, InterPro:IPR002301, InterPro:IPR009008, InterPro:IPR009080, InterPro:IPR013155 (FlyBase Curators et al., 2004-) isoleucine-tRNA ligase activity inferred from sequence or structural similarity (Spradling et al., 1999) inferred from sequence or structural similarity with Saccharomyces ILS1 (FlyBase, 1992-)
Biological Process
CV term Evidence References
isoleucyl-tRNA aminoacylation inferred from sequence or structural similarity with Saccharomyces ILS1 (FlyBase, 1992-)
Cellular Component
CV term Evidence References
cytoplasm inferred from electronic annotation with InterPro:IPR001412, InterPro:IPR002300, InterPro:IPR002301, InterPro:IPR009008, InterPro:IPR009080, InterPro:IPR013155 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Aats-ile - Aats-arg experimental knowledge based (Guruharsha et al., 2011) Aats-ile - Aats-asn anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Aats-ile - Aats-asp experimental knowledge based (Guruharsha et al., 2011) Aats-ile - Aats-gln anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Aats-ile - Aats-glupro experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) Aats-ile - Aats-lys anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Aats-ile - CG10496 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Aats-ile - CG10934 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Aats-ile - CG15100 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Aats-ile - CG2183 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Aats-ile - CG2789 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Aats-ile - CG30184 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Aats-ile - CG5027 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Aats-ile - CG5190 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Aats-ile - CG5850 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Aats-ile - CG5886 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Aats-ile - CG6652 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Aats-ile - CG8235 experimental knowledge based (Guruharsha et al., 2011) Aats-ile - CG9062 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Aats-ile - Cyp9b2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Aats-ile - Gmd anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Aats-ile - Jon65Ai anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Aats-ile - Nup50 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Aats-ile - Pdk1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Aats-ile - Pp2B-14D anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Aats-ile - RluA-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Aats-ile - Saf-B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Aats-ile - Sbp2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Aats-ile - TfIIEα anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Aats-ile - Tg anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Aats-ile - inaC anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Aats-ile - lectin-46Ca anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Aats-ile - phl anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Aats-ile - rho anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Aats-ile - stas anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Aats-ile - βCop experimental knowledge based (Guruharsha et al., 2011)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Aats-ile allele Gene References
External Data
Linkouts	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0027086 DroID - A comprehensive database of gene and protein interactions. • FBgn0027086 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 45785
Orthologs
OrthoDB Orthologs (39) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6MCXJP Dipteran inclusive ortholog search EOG602X14 Insect inclusive ortholog search EOG6J6QKQ Arthropod inclusive ortholog search EOG6W9GJQ Metazoa inclusive ortholog search EOG6C8MK1
Orthologs in Drosophila Species (EOG6MCXJP)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Aats-ile     Drosophila simulans   Dsim\GD15025 Y   Drosophila sechellia   Dsec\GM22440 Y   Drosophila erecta   Dere\GG16252 Y   Drosophila yakuba   Dyak\GE22611 Y   Drosophila ananassae   Dana\GF10975 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA11021 Y   Drosophila persimilis   Dper\GL16214 Y   Drosophila willistoni   Dwil\GK16057 Y   Drosophila virilis   Dvir\GJ11630 Y   Drosophila mojavensis   Dmoj\GI11376 Y   Drosophila grimshawi   Dgri\GH16690 Y
Orthologs in non-Drosophila Dipterans (EOG602X14)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL000388   Anopheles gambiae Malaria mosquito  Agam\AGAP002101   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ016361
Orthologs in non-Dipteran Insects (EOG6J6QKQ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\Aats-ile   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG009192   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH18237   Atta cephalotes Leafcutter ant  Acep\ileS   Camponotus floridanus Florida carpenter ant  Cflo\ileS   Harpegnathos saltator Jerdons jumping ant  Hsal\ileS   Linepithema humile Argentine ant  Lhum\LH17135   Pogonomyrmex barbatus Red harvester ant  Pbar\PB18968   Solenopsis invicta Red fire ant  Sinv\SINV14636   Acyrthosiphon pisum Pea aphid  Apim\ACYPI006430   Bombyx mori Silkmoth  Bmor\BGIBMGA001558   Pediculus humanus Human body louse  Phum\PHUM515270   Tribolium castaneum Red flour beetle  Tcas\TC010772
Orthologs in non-Insect Arthropods (EOG6W9GJQ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\ileS   Ixodes scapularis Deer tick  Isca\ISCW013321
Orthologs in non-Arthropod Metazoa (EOG6C8MK1)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\irs-1   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_008455gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_021302gn   Danio rerio Zebrafish  Drer\iars   Xenopus tropicalis Western clawed frog  Xtro\iars   Gallus gallus Domestic chicken  Ggal\IARS   Mus musculus House mouse  Mmus\Iars   Rattus norvegicus Norway rat  Rnor\Iars   Homo sapiens Human  Hsap\IARS
Human Orthologs (1)
Gene OMIM HGNC Hsap\IARS
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD15025 Drosophila sechellia Dsec\GM22440 Drosophila erecta Dere\GG16252 Drosophila yakuba Dyak\GE22611 Drosophila ananassae Dana\GF10975 Drosophila pseudoobscura pseudoobscura Dpse\GA11021 Drosophila persimilis Dper\GL16214 Drosophila willistoni Dwil\GK16057 Drosophila virilis Dvir\GJ11630 Drosophila mojavensis Dmoj\GI11376 Drosophila grimshawi Dgri\GH16690
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	11510 P{PZ}Aats-ile00827 ry506/TM3, ryRK Sb1 Ser1 19905 y1 w67c23; P{EPgy2}Aats-ileEY03542/TM3, Sb1 Ser1
Harvard	- PBac{WH}Aats-ilef01737
Kyoto	124179 w1118; P{RS3}Aats-ileCB-6683-3
Genomic Clones ( 1 )
	BACR48E10 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 311 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD27166
Other clones	DPiM_LD27166
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT15835 GM04407 GM18963 GM21401 GM31217 LD03435 LD03957 LD06755 LD10677 LD10833 LD11930 LD22586 LD22795 LD26368 LD27628 LD28231 LD28834 LD32144 LD33304 LD33516 LD36176 LD36745 LD37748 LD37873 LD39666 LD40163 LD41920 LD45986 LD46446 LP13912 LP13936 LP16327 RE02583 RE03568 RE16258 RE19951 RE20189 RE26880 RE29617 RE33394 RE35746 RE35796 RE42772 RE46465 RE56747 RE56793 RE57854 RE58621 RE64078 RE65892 RE66010 RE66682 RE66851 RE68570 RE68595 RE70438 RE74947 SD02782 SD02961 SD05356 SD06323 SD06792 SD07130 SD07224 SD11188 SD12030 SD12836 SD13045 SD18720 SD19007 SD26887
Other clones	5281 70448 73629 147708 274864 CK01.35C.B2 CK02366 Dmel_dig_016909_0713_1988 EK030328 EK124340 EK253064 EK302547 GM06592 LD29251 LD35356 RM01031 RM01131 RM01231 RM01531 RM01631 RM01731 RP01065 RP01132 RP01318 RP01324 RP01332 RP01385 RP01417 RP01418 RP01431 RP01527 RP01551 RP001001486 RP001001952 RP001002165 RP001002370 RP001002897 RP001003281 RP001005458 RP001005949 RP001006033 RP001006208 RP001006834 RP001006902 RP001007120 RP001007672 RP001007924 RP001008310 RP001008775 RP001008868 RP001009274 RP001009460 RP001009583 RP001009833 RP001010515 RP001011034 RP001011105 RP001011556 RP001012108 RP001012453 RP001012714 RP001014048 RP001014827 RP001014991 RP001015139 RP001015142 RP001015164 RP001015193 RP001015430 RP001015613 RP001015620 RP001015676 RP001016066 RP001016157 RP001016245 RP001016829 RP001016901 RP001016918 RP001017159 RP001017187 RP001017356 RP001017439 RP001017841 RP001017946 RP001017982 RP001018105 RP001018225 RP001018226 RP001018382 RP001018818 RP001019071 RP001019150 RP001019418 RP001019442 RP001019738 RP001019828 RP001019878 RP001020110 RP001020133 RP001020354 RP001020447 RP001020602 RP001020721 RP001021043 RP001021045 RP001021656 RP001021853 RP001022039 RP001022074 RP001022609 RP001022926 RP001023001 RP001023371 RP001023467 RP001023518 RP001023595 RP001023863 RP001024259 RP001024826 RP001024859 RP001025203 RP001025736 RP001025853 RP001025888 RP001026376 RP001026638 RP001027135 RP001028026 RP001028416 RP001028554 RP001028561 RP001029481 RP001029811 RP001030108 RP001030158 RP001030181 RP001030917 RP001031654 RP001031722 RP001031778 RP001032488 RP001032614 RP001032645 RP001033060 RP001033136 RP001033186 RP001033342 RP001033562 RP001033728 RP001033868 RP001034371 RP001034591 RP001034655 RP001034998 RP001035343 RP001035394 RP001035661 RP001035701 RP001036102 RP001036725 RP001037271 RP001037773 RP001038113 RP001038368 RP001038369 RP001038408 RP001038442 RP001038554 RP001039064 RP001039098 RP001039111 RP001039737 RP001040148 RP001040150 RP001040300 RP001040427 RP001040469 RP001040728 RP001040893 RP001041068 RP001041159 RP001042386 RP001042463 RP001042524 RP001042757 RP001042996 RP001043141 RP001043309 RP001043500 RP001043700 RP001044273 RP001044392 RP001045026 RP001045085 RP001045185 RP001045198 RP001045333 RP001045354 RP001046110 RP001046748 RP001046856 RP001047314 RP001047421 RP001047634 RP001047678 RP001048263 RP001048312 RP001048588 RP001048791 RP001048796 RP001049335 RP001050237 RP001050264 RP001050299 RP001050584 RP001051209 RP001051369 RP001051381 RP001051415 RP001051579 RP001051595 RP001051636 RP001051831 RP001051845 RP001052033 RP001052240 RP001052311 RP001052388 RP001053068 RP001053735 RP001054875 RP001055083 RP001055239 RP001055669 RP001055949 RP001056089 RP001056357 RP001056593
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0027086 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 45785
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Aats-ile CG11471 (Misra, 2000.8.9) Source for merge of: Aats-ile l(3)00827 (Spradling et al., 1999)
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080101 NM_168952 NM_176387 RefSeq (Proteins) • NP_524840 NP_730716 NP_788565 DDBJ / EMBL / GenBank • AA392674 AA695742 AA941855 AAF51822 AAF51823 AAM49907 AAO41285 AQ026160 AW942740 AY118538 CL632139 CZ484204 Entrez Gene - A searchable database of RefSeq genes. • 45785 UniProtKB/TrEMBL • Q8MSW0
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Aminoacyl-tRNA synthetase, class I, conserved site (IPR001412) Aminoacyl-tRNA synthetase, class Ia (IPR002300) Isoleucine-tRNA ligase (IPR002301) Valyl/Leucyl/Isoleucyl-tRNA synthetase, class Ia, editing domain (IPR009008) Aminoacyl-tRNA synthetase, class 1a, anticodon-binding (IPR009080) Valyl/Leucyl/Isoleucyl-tRNA synthetase, class I, anticodon-binding (IPR013155) Isoleucine-tRNA ligase, type 2 (IPR023586) Rossmann-like alpha/beta/alpha sandwich fold (IPR014729) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD27166
Linkouts
	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0027086 DroID - A comprehensive database of gene and protein interactions. • FBgn0027086 DRSC - Results from RNAi screens. • FBgn0027086 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0027086 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11471-RC FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0027086 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 45785 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 45785 modMine - Data generated by the modENCODE project. • FBgn0027086
Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	Aats-ile (Stuart et al., 2007, Christensen et al., 2008.4.15, Christensen et al., 2008.4.15, Wong et al., 2005, Slack et al., 2006, Loop et al., 2004, Bridon et al., 2012, Japanese National Institute of Genetics, 2012.5.21) CG11471 (Bridon et al., 2012) IleRS (Seshaiah and Andrew, 1999.7.29) IRS (Seshaiah and Andrew, 1999) l(3)00827 (Meister and Braun, 1995.10, Baumgartner et al., 1995, BDGP Project Members, 1994-1999, )
Name Synonym	Isoleucyl-tRNA synthetase (Seshaiah and Andrew, 1999)
Secondary FlyBase IDs
	FBgn0010728 FBgn0037159
References ( 33 )
Generate a list of	All references relating to this gene ( 33 )
List References by type	Research paper  ( 9 ) Supplementary material  ( 4 ) Personal communication to FlyBase  ( 14 ) FlyBase analysis  ( 2 ) Stock list  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 1 )
	Bridon et al., 2012, J. Proteome Res. 11(2): 927--940 Improvement of Phosphoproteome Analyses Using FAIMS and Decision Tree Fragmentation. Application to the Insulin Signaling Pathway in Drosophila melanogaster S2 Cells. [FBrf0217365] Show all research papers ...