FlyBase Gene Report: Dmel\Dyrk3

DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION REGULATED KINASES -: The DYRK (Dual-specificity tyrosine phosphorylation-regulated kinase) family kinases phosphorylate serine/threonine on other proteins (trans-phosphorylation), but can also autophosphorylate on tyrosine. Autophosphorylation within the activation loop occurs while still attached to the ribosome. (Adapted from PMID:15960979).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the GBrowse view of Dmel\Dyrk3 or the JBrowse view of Dmel\Dyrk3 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.46

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Dyrk3-RA

FBtr0100402

NM_001038721

3384

828

Dyrk3-RC

FBtr0100404

NM_001038723

3320

828

Dyrk3-RE

FBtr0100406

NM_001038725

4032

828

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Dyrk3-PA

FBpp0099816

92.7

828

8.70

NP_001033810

ABC65837

Dyrk3-PC

FBpp0099818

92.7

828

8.70

NP_001033812

ABC65839

Dyrk3-PE

FBpp0099820

92.7

828

8.70

NP_001033814

ABC65841

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

828 aa isoforms: Dyrk3-PA, Dyrk3-PC, Dyrk3-PE

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Post Translational Modification

Autophosphorylated on tyrosine residues.

(UniProt, P83102)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

P83102

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Dyrk3 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Dyrk3_1

Linkouts

Gene Ontology (7 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

ATP binding

inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR002290, InterPro:IPR017441

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

protein serine/threonine kinase activity

inferred from biological aspect of ancestor with PANTHER:PTN000624408

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

peptidyl-serine phosphorylation

inferred from biological aspect of ancestor with PANTHER:PTN000624408

(assigned by GO_Central )

(Gaudet et al., 2011)

peptidyl-threonine phosphorylation

inferred from biological aspect of ancestor with PANTHER:PTN000624408

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

cytoplasm

inferred from biological aspect of ancestor with PANTHER:PTN000624546

(assigned by GO_Central )

(Gaudet et al., 2011)

cytoskeleton

inferred from biological aspect of ancestor with PANTHER:PTN000624546

(assigned by GO_Central )

(Gaudet et al., 2011)

nucleus

inferred from biological aspect of ancestor with PANTHER:PTN001173333

(assigned by GO_Central )

(Gaudet et al., 2011)

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 13 -- 16

organism | faint | ubiquitous

(Fisher et al., 2012)

pharate adult stage P9

third segment of antenna | restricted

(Luebbering et al., 2013)

late third instar larval stage

morphogenetic furrow

(Luebbering et al., 2013)

Additional Descriptive Data

Dyrk3 transcript is expressed in the third antennal segment in late pupae (65 hr APF). Dyrk3 transcript is expressed the morphogenetic furrow of the eye disc in late third instar larvae; transcript is not detected in the antennal disc at this stage. Eye disc morphogenetic furrow expression is localized slightly ahead of elav-expressing terminally differentiated neuronal cells.

(Luebbering et al., 2013)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

late third instar larval stage

morphogenetic furrow

(Luebbering et al., 2013)

Additional Descriptive Data

Dyrk3 protein is expressed the morphogenetic furrow of the eye disc in late third instar larvae; localized slightly ahead of elav-expressing terminally differentiated neuronal cells.

(Luebbering et al., 2013)

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Dyrk3 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Dyrk3

View exonic expression by tissue for Dmel\Dyrk3

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0027101

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0027101

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG40478-RA

Flygut - An atlas of the Drosophila adult midgut

FBgn0027101

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 2 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 5 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Dyrk3

Transgenic constructs containing regulatory region of Dyrk3

Deletions and Duplications ( 1 )

Disrupted in

Df(4)TZ^DC

(Zhang et al., 2015)

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

Dyrk3^118E-15

Sterility

Allele

female semi-sterile, with Scer\GAL4^nos.PG, Scer\GAL4^VP16.nos.UTR, Scer\GAL4^VP16.otu

Dyrk3^GL00283

female semi-sterile, with Scer\GAL4^{VP16.mat.αTub67C}

Dyrk3^GL01131

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v7.1)

Homo sapiens (Human) (14)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\DYRK2

10 of 15

Yes

Hsap\DYRK3

9 of 15

Yes

3 of 15

3 of 15

3 of 15

3 of 15

3 of 15

3 of 15

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Model Organism Orthologs (via DIOPT v7.1)

Mus musculus (laboratory mouse) (13)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Dyrk2

10 of 15

Yes

Mmus\Dyrk3

9 of 15

Yes

4 of 15

3 of 15

3 of 15

3 of 15

2 of 15

2 of 15

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Rattus norvegicus (Norway rat) (14)

Rnor\Dyrk2

9 of 13

Yes

Rnor\Dyrk3

4 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Xenopus tropicalis (Western clawed frog) (7)

Xtro\dyrk2

5 of 12

Yes

Xtro\dyrk3

4 of 12

Yes

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

Danio rerio (Zebrafish) (17)

Drer\dyrk2

10 of 15

Yes

Drer\zgc:172180

6 of 15

Yes

4 of 15

3 of 15

3 of 15

3 of 15

2 of 15

2 of 15

Drer\si:ch211-160o17.4

2 of 15

Drer\admb

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Drer\prpf4ba

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (7)

Cele\mbk-2

10 of 15

Yes

Cele\C36B7.1

3 of 15

Yes

3 of 15

3 of 15

1 of 15

1 of 15

1 of 15

Arabidopsis thaliana (thale-cress) (12)

Atha\AT2G40120

2 of 9

Yes

Atha\AT4G03175

2 of 9

Yes

Atha\AME3

1 of 9

Atha\AT1G13350

1 of 9

Atha\AT1G73450

1 of 9

Yes

Atha\AT1G73460

1 of 9

Yes

Atha\AT3G17750

1 of 9

Yes

1 of 9

1 of 9

1 of 9

1 of 9

1 of 9

Saccharomyces cerevisiae (Brewer's yeast) (2)

Scer\YAK1

5 of 15

Yes

Scer\KNS1

1 of 15

Schizosaccharomyces pombe (Fission yeast) (5)

Spom\pom1

5 of 12

Yes

3 of 12

2 of 12

1 of 12

1 of 12

Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091902ZK )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila melanogaster

fruit fly

Dmel\Dyrk3

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA27948

Drosophila persimilis

Dper\GL18373

Drosophila willistoni

Dwil\GK13652

Drosophila virilis

Dvir\GJ14450

Drosophila mojavensis

Dmoj\GI14115

Drosophila grimshawi

Dgri\GH23987

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091503RL )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17006271

Musca domestica

House fly

Mdoa\17012937

Glossina morsitans

Tsetse fly

Gmor\GMOY001747

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_00103

Mayetiola destructor

Hessian fly

Mdes\Mdes008131

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL001731

Anopheles darlingi

American malaria mosquito

Adar\ADAC002035

Anopheles gambiae

Malaria mosquito

Agam\AGAP008241

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ014802

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ014803

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W034I )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA004611

Bombyx mori

Silkmoth

Bmor\BGIBMGA006111

Danaus plexippus

Monarch butterfly

Dple\DPOGS215434-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS201564-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL004717

Heliconius melpomene

Postman butterfly

Hmel\HMEL015837

Apis florea

Little honeybee

Aflo\2399304964

Apis florea

Little honeybee

Aflo\2293491844

Apis mellifera

Western honey bee

Amel\GB48589

Apis mellifera

Western honey bee

Amel\GB51445

Apis mellifera

Western honey bee

Amel\GB52508

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP22707

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP16428

Bombus terrestris

Buff-tailed bumblebee

Bter\15214582

Bombus terrestris

Buff-tailed bumblebee

Bter\15209190

Linepithema humile

Argentine ant

Lhum\LH15563

Linepithema humile

Argentine ant

Lhum\LH16480

Linepithema humile

Argentine ant

Lhum\LH16479

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:002028

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:002467

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG014340

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG007499

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_11370

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_06730

Tribolium castaneum

Red flour beetle

Tcas\TC013573

Tribolium castaneum

Red flour beetle

Tcas\TC014135

Pediculus humanus

Human body louse

Phum\PHUM463810

Pediculus humanus

Human body louse

Phum\PHUM574200

Rhodnius prolixus

Kissing bug

Rpro\RPRC006548

Rhodnius prolixus

Kissing bug

Rpro\RPRC001740

Cimex lectularius

Bed bug

Clec\CLEC005496

Cimex lectularius

Bed bug

Clec\CLEC002884

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI073700

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_03075

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_11623

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0G88 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR014657

Ixodes scapularis

Black-legged tick

Isca\ISCW018301

Stegodyphus mimosarum

African social velvet spider

Smim\KFM68594.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM56935.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM80615.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM79592.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur12g03580

Tetranychus urticae

Two-spotted spider mite

Turt\tetur07g04070

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_51930

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_49628

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0Q46 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Dyrk4

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Dyrk4_1

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Dyrk2

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000007679

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000020453

Gallus gallus

Domestic chicken

Ggal\DYRK3

Gallus gallus

Domestic chicken

Ggal\DYRK2

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v7.1)

Drosophila melanogaster (Fruit fly) (5)

Gene Symbol

Score

Source

Alignment

7 of 10

5 of 10

mnb

5 of 10

CG7028

1 of 10

Doa

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

DYRK2; dual specificity tyrosine phosphorylation regulated kinase 2

10 of 15

603496

DYRK3; dual specificity tyrosine phosphorylation regulated kinase 3

9 of 15

603497

DYRK1A; dual specificity tyrosine phosphorylation regulated kinase 1A

3 of 15

600855

MENTAL RETARDATION, AUTOSOMAL DOMINANT 7; MRD7

autosomal dominant non-syndromic intellectual disability 7

DYRK1B; dual specificity tyrosine phosphorylation regulated kinase 1B

3 of 15

604556

ABDOMINAL OBESITY-METABOLIC SYNDROME 3; AOMS3

abdominal obesity-metabolic syndrome 3

DYRK4; dual specificity tyrosine phosphorylation regulated kinase 4

3 of 15

609181

HIPK1; homeodomain interacting protein kinase 1

3 of 15

608003

HIPK2; homeodomain interacting protein kinase 2

3 of 15

606868

HIPK3; homeodomain interacting protein kinase 3

3 of 15

604424

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0027101

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

3885567

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Regulation of TP53 Activity through Phosphorylation

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

4-0

Cytogenetic map

102F8-102F8

Sequence location

4:1,225,089..1,230,713 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

102F8-102F8

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

102F8-102F8

(Drosophila Heterochromatin Genome Project, 2004)

102F-102F

(Wallrath, 1998.11.2)

Experimentally Determined Recombination Data

Location

4-0

(FlyBase, 2016)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (7)

Bloomington

60800

y¹; Mi{MIC}Dyrk3^MI06694

84107

y¹ w^67c23; P{hsp26-pt-T}Dyrk3^118E-15

35370

y¹ sc^* v¹ sev²¹; P{TRiP.GL00283}attP2

41595

y¹ sc^* v¹ sev²¹; P{TRiP.GL01131}attP2

55882

y¹ sc^* v¹ sev²¹; P{TRiP.HMC04155}attP2

VDRC

v330642

P{VSH330642}attP40

v342014

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD01368}attP40/CyO-GFP

Genomic Clones (0)

cDNA Clones (123)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequences

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0027101

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0027101

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

3885567

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: Dyrk3 unknown-telomeric-protein-gene

(Manning, 2001.10.15)

Source for database merge of

Source for merge of: Dyrk3 BcDNA:RE60792

(FlyBase, 1996-)

Source for merge of: Dyrk3 CG40478

(FlyBase, 1996-)

Additional comments

Source for merge of Dyrk3 BcDNA:RE60792 was sequence comparison ( date:030828 ).

(FlyBase, 1996-)

Source for merge of Dyrk3 CG40478 was sequence comparison.

(FlyBase, 1996-)

Other Comments

New annotation (CG40478) in release 3.2 of the genome annotation.

(Drosophila Heterochromatin Genome Project, 2004)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 43 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

3885567

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P83102

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0027101

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0027101

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Dyrk3_1

Flygut - An atlas of the Drosophila adult midgut

FBgn0027101

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

3885567

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC014135

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG40478

modMine - A data warehouse for the modENCODE project

FBgn0027101

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Regulation of TP53 Activity through Phosphorylation

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

P83102

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0027101

DRSC - Results frm RNAi screens

FBgn0027101

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0027101

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG40478-RA

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0027101

FlyMine - An integrated database for Drosophila genomics

FBgn0027101

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

3885567

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Regulation of TP53 Activity through Phosphorylation

Synonyms and Secondary IDs (10)

Reported As

Symbol Synonym

BcDNA:RE60792

CG40478

(Meadows, 2018.10.31, Ni et al., 2011.7.19, Ni et al., 2010.12.1, Gwack et al., 2006, Robinson and Marchant, 2006, Drosophila Heterochromatin Genome Project, 2004, FlyBase Genome Annotators, 2004)

DDYRK3

(Lochhead et al., 2003)

DYRK3

(Kinstrie et al., 2010)

Dm3

(Kinstrie et al., 2010)

DmDyrk3

(Luebbering et al., 2013)

Dyrk3

(Shrestha et al., 2017, Figueiredo et al., 2014, Sopko et al., 2014, Cryderman et al., 2011, Sun et al., 2004)

FBtr0100406

(Li et al., 2012)

Name Synonyms

Dual-specificity tyrosine phosphorylation-regulated kinase 3

(Luebbering et al., 2013)

Dyrk3

unknown-telomeric-protein-gene

Secondary FlyBase IDs

FBgn0062988
FBgn0069975

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Study focus (0)

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References (32)

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