FB2025_01 , released February 20, 2025
Gene: Dmel\Gmap
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General Information
Symbol
Dmel\Gmap
Species
D. melanogaster
Name
Golgi microtubule-associated protein
Annotation Symbol
CG33206
Feature Type
protein_coding_gene
FlyBase ID
FBgn0027287
Gene Model Status
Current
Stock Availability
15 publicly available
Gene Summary
Golgi microtubule-associated protein (Gmap) encodes a peripheral Golgi protein that is required for the efficient trafficking within the early secretory pathway, probably by recruiting Rab proteins and effector molecules. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)
All Summaries
Also Known As

dGMAP, l(1)G0168

Key Links
Genomic Location
Cytogenetic map
13C5-13C7
Sequence location
Recombination map
1-50
RefSeq locus
NC_004354 REGION:15486922..15511223
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (12 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
enables cargo receptor activity
inferred from mutant phenotype
(Park et al., 2022)
enables small GTPase binding
inferred from physical interaction with FLYBASE:Rab2; FB:FBgn0014009
(Sinka et al., 2008)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables small GTPase binding
inferred from biological aspect of ancestor with PANTHER:PTN001054374
(GO Reference Genome Project, 2011-)
Biological Process (5 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
involved_in Golgi organization
inferred from mutant phenotype
(Friggi-Grelin et al., 2006)
involved_in intra-Golgi vesicle-mediated transport
inferred from mutant phenotype
(Park et al., 2022)
involved_in vesicle tethering to Golgi
inferred from mutant phenotype
(Park et al., 2022)
involved_in vesicle-mediated transport
inferred from direct assay
(Friggi-Grelin et al., 2006)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport
inferred from biological aspect of ancestor with PANTHER:PTN001054374
(GO Reference Genome Project, 2011-)
involved_in Golgi organization
inferred from biological aspect of ancestor with PANTHER:PTN001054374
(GO Reference Genome Project, 2011-)
Cellular Component (6 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
is_active_in cis-Golgi network membrane
inferred from direct assay
(Park et al., 2022)
located_in Golgi cis cisterna
inferred from direct assay
(Friggi-Grelin et al., 2006)
located_in Golgi membrane
inferred from direct assay
(Zhou et al., 2014)
located_in Golgi stack
inferred from direct assay
(Friggi-Grelin et al., 2006)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in Golgi apparatus
inferred from biological aspect of ancestor with PANTHER:PTN001054374
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Golgi microtubule-associated protein (Gmap) encodes a peripheral Golgi protein that is required for the efficient trafficking within the early secretory pathway, probably by recruiting Rab proteins and effector molecules. [Date last reviewed: 2019-03-07]
Gene Group (FlyBase)
GOLGINS -
Golgins are long, parallel coiled-coil homodimers important in regulating vesicle mediated transport and Golgi architecture. They are anchored to specific sites on the Golgi complex surface either by a C-terminal transmembrane domain or interacting with Arf/Arf-like GTPases via a GRIP/GRAB domain. Golgins are thought to act as tethering factors, interacting with vesicles by binding Rab GTPases and guiding them to the correct Golgi cisternae. (Adapted from PMID:21436057).
Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
3

Please see the JBrowse view of Dmel\Gmap for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry A0A4D6K5M0)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.52

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.42

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Stop-codon suppression (UGA) postulated; FBrf0234051.

Gene model reviewed during 6.25

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Gmap-RA
FBtr0074042
NM_176734
4899
1398
Gmap-RB
FBtr0074043
NM_176735
4707
1208
Gmap-RC
FBtr0343525
NM_001298345
5007
1208
Gmap-RD
FBtr0474150
NM_001370008
4899
1401
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Gmap-PA
FBpp0073859
158.5
1398
4.42
Q9VXU2
NP_788907
AAF48466
Gmap-PB
FBpp0073860
137.8
1208
4.51
Q9VXU1
NP_788908
AAF48467
Gmap-PC
FBpp0310129
137.8
1208
4.51
Q9VXU1
NP_001285274
AHN59744
Gmap-PD
FBpp0423149
158.8
1401
4.42
QCD25241
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1208 aa isoforms: Gmap-PB, Gmap-PC
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Gmap using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.31

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 5
organism | ubiquitous
(Friggi-Grelin et al., 2006)
cephalic furrow

Comment: stronger expression

(Friggi-Grelin et al., 2006)
embryonic stage 5 -- 6
primordial germ cell

Comment: stronger expression

(Friggi-Grelin et al., 2006)
embryonic stage 6 -- 9
embryonic ocular segment

Comment: stronger expression

(Friggi-Grelin et al., 2006)
embryonic stage 6 -- 10
embryonic/larval midgut primordium

Comment: stronger expression

(Friggi-Grelin et al., 2006)
embryonic stage 11
embryonic foregut

Comment: stronger expression

(Friggi-Grelin et al., 2006)
embryonic hindgut

Comment: stronger expression

(Friggi-Grelin et al., 2006)
embryonic stage 11 -- 16
embryonic/larval midgut

Comment: stronger expression

(Friggi-Grelin et al., 2006)
embryonic stage 12 -- 16
embryonic/larval gut

Comment: stronger expression

(Friggi-Grelin et al., 2006)
embryonic stage 16
embryonic/larval tracheal section

Comment: stronger expression

(Friggi-Grelin et al., 2006)
embryonic/larval salivary gland

Comment: stronger expression

(Friggi-Grelin et al., 2006)
cercus

Comment: stronger expression

(Friggi-Grelin et al., 2006)
larval antenno-maxillary sensory complex

Comment: stronger expression

(Friggi-Grelin et al., 2006)
Additional Descriptive Data

Gmap is ubiquitously expressed in embryos but is more strongly expressed in some tissues. During embryonic stage 5, strong expression is seen in pole cells can cells in the cephalic furrow. In subsequent stages, strong expression is seen in the posterior midgut. The acron is stongly labeled in stages 6, 8, and 9. At stage 11, Gmap is strongly expressed in the fore-, mid- and hindguts. At stage 12 expression is more uniform but is still stronger in the gut. At stage 16, expression is strong in the gut, the antenno-maxillary complex, salivary glands, anal plates, and trachea.

(Friggi-Grelin et al., 2006)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
organism | ubiquitous
(Friggi-Grelin et al., 2006)
larval stage
imaginal disc | ubiquitous
(Friggi-Grelin et al., 2006)
larval central nervous system | ubiquitous
(Friggi-Grelin et al., 2006)
embryonic/larval salivary gland | ubiquitous
(Friggi-Grelin et al., 2006)
S2 cell-line
(Aikin et al., 2012)
Additional Descriptive Data

Gmap is ubiquitously expressed at a similar level in the entire embryo and also in larval tissues studied.

(Friggi-Grelin et al., 2006)
Marker for
 
cis-Golgi network
(Aikin et al., 2012)
Subcellular Localization
CV Term
Evidence
References
is_active_in cis-Golgi network membrane
inferred from direct assay
(Park et al., 2022)
located_in Golgi cis cisterna
inferred from direct assay
(Friggi-Grelin et al., 2006)
located_in Golgi membrane
inferred from direct assay
(Zhou et al., 2014)
located_in Golgi stack
inferred from direct assay
(Friggi-Grelin et al., 2006)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Gmap in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 26 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 10 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Gmap
Transgenic constructs containing regulatory region of Gmap
Aberrations (Deficiencies and Duplications) ( 0 )
Inferred from experimentation ( 0 )
Inferred from location ( 6 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (1)
Hsap\TRIP11
8 of 14
Yes
Yes
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (1)
Rnor\Trip11
8 of 14
Yes
Yes
Mus musculus (laboratory mouse) (1)
Mmus\Trip11
8 of 14
Yes
Yes
Xenopus tropicalis (Western clawed frog) (3)
Xtro\trip11
5 of 13
Yes
Yes
Xtro\LOC101732590
1 of 13
No
Yes
Xtro\mier2
1 of 13
No
No
Danio rerio (Zebrafish) (1)
Drer\trip11
8 of 14
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\sql-1
4 of 14
Yes
Yes
Anopheles gambiae (African malaria mosquito) (1)
Agam\AgaP_AGAP003457
10 of 12
Yes
Yes
Arabidopsis thaliana (thale-cress) (2)
Atha\GC4
1 of 13
Yes
Yes
Atha\GDAP1
1 of 13
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\RUD3
1 of 13
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\SPBC119.12
1 of 12
Yes
Yes
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Gmap. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Human Ortholog
    Disease
    Evidence
    References
    TRIP11; thyroid hormone receptor interactor 11
    model of  achondrogenesis type IA
    IEA
    (FlyBase, 2019-)
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    TRIP11; thyroid hormone receptor interactor 11
    8 of 14
    604505
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Show/hide secondary interactors 
    (data from AllianceMine provided by esyN)
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Other Interaction Browsers
    View in FlyBase Interactions Browser   View in MIST tool (external link)
    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    Gmap - Arf1
    pull down, peptide massfingerprinting
    (Christis and Munro, 2012)
    Gmap - Arf4
    pull down, peptide massfingerprinting
    (Christis and Munro, 2012)
    Gmap - Atg8a
    pull down, molecular weight estimation by staining
    (Rahman et al., 2022)
    Gmap - Rab2
    two hybrid, pull down, peptide massfingerprinting, western blot
    (Gillingham et al., 2014, Sinka et al., 2008)
    Summary of Genetic Interactions
    esyN Network Diagram
    Show/hide secondary interactors 
    (data from AllianceMine provided by esyN)
    esyN Network Key:
    Suppression
    Enhancement
    Other Interaction Browsers
    View in FlyBase Interactions Browser   View in MIST tool (external link)
    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Gmap
    enhanceable
    cos
    (Friggi-Grelin et al., 2008)
    Gmap
    enhanceable
    Su(fu)
    (Friggi-Grelin et al., 2008)
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    FlyBase
    External Links
    External Data
    Linkouts
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    Class of Gene
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    X
    Recombination map
    1-50
    Cytogenetic map
    13C5-13C7
    Sequence location
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    13C5-13C7
    Limits computationally determined from genome sequence between P{EP}CG6340EP1109&P{EP}l(1)G0168EP491 and P{EP}EP1489
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    13D1-13D2
    (determined by in situ hybridisation)
    (Peter et al., 2002, Schäfer et al., 1999.6.15)
    Experimentally Determined Recombination Data
    Location

    1-50

    (FlyBase, 2016)

    1-50.9

    (Comeron et al., 2012)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (15)
    Genomic Clones (19)
    cDNA Clones (22)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      Antibody Information
      Laboratory Generated Antibodies
       

      polyclonal

      (Riedel et al., 2016)
      Commercially Available Antibodies
       
      Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
      Cell Line Information
      Publicly Available Cell Lines
       
      Other Stable Cell Lines
       
        Other Comments

        Nonsense-mediated mRNA decay (NMD) down-regulates a distinct splice isoform(s) of this gene.

        (Hansen et al., 2009)
        Relationship to Other Genes
        Source for database merge of

        Source for merge of: l(1)G0168 CG33206

        (Peter et al., 2002)
        Additional comments

        Annotations CG6350, CG7821 merged as CG33206 in release 3 of the genome annotation.

        (FlyBase Genome Annotators, 2002-2003)
        Nomenclature History
        Source for database identify of

        Source for identity of: Gmap l(1)G0168

        (Friggi-Grelin et al., 2006)
        Nomenclature comments
        Etymology
        Synonyms and Secondary IDs (13)
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        Study result (0)
        Result
        Result Type
        Title
        External Crossreferences and Linkouts ( 53 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
        Other crossreferences
        AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
        DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
        EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
        FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
        FlyMine - An integrated database for Drosophila genomics
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        MARRVEL_MODEL - MARRVEL (model organism gene)
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        Flygut - An atlas of the Drosophila adult midgut
        FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        References (67)