FB2025_01 , released February 20, 2025
Gene: Dmel\Idh3a
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General Information
Symbol
Dmel\Idh3a
Species
D. melanogaster
Name
Isocitrate dehydrogenase (NAD+) 3 catalytic subunit alpha
Annotation Symbol
CG12233
Feature Type
protein_coding_gene
FlyBase ID
FBgn0027291
Gene Model Status
Current
Stock Availability
11 publicly available
Enzyme Name (EC)
isocitrate dehydrogenase (NAD(+)) (1.1.1.41)
Gene Summary
Probable catalytic subunit of the enzyme which catalyzes the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. (UniProt, Q9VWH4)
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

l(1)G0156, lethal (1) G0156

Key Links
Genomic Location
Cytogenetic map
18C8-18C8
Sequence location
Recombination map
1-62
RefSeq locus
NC_004354 REGION:19518428..19521810
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (9 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables isocitrate dehydrogenase (NAD+) activity
inferred from mutant phenotype
(Ugur et al., 2017)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
enables isocitrate dehydrogenase (NAD+) activity
inferred from biological aspect of ancestor with PANTHER:PTN000216787
(GO Reference Genome Project, 2011-)
inferred from sequence or structural similarity with UniProtKB:P56471
(Gene Ontology Curators, 2002-)
enables magnesium ion binding
inferred from electronic annotation with InterPro:IPR019818
(InterPro Project Members, 2004-)
enables NAD binding
inferred from electronic annotation with InterPro:IPR019818
(InterPro Project Members, 2004-)
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
inferred from electronic annotation with InterPro:IPR019818
(InterPro Project Members, 2004-)
Biological Process (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
involved_in tricarboxylic acid cycle
inferred from mutant phenotype
(Ugur et al., 2017)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in isocitrate metabolic process
inferred from biological aspect of ancestor with PANTHER:PTN000216787
(GO Reference Genome Project, 2011-)
involved_in tricarboxylic acid cycle
inferred from electronic annotation with InterPro:IPR004434
(InterPro Project Members, 2004-)
inferred from biological aspect of ancestor with PANTHER:PTN000216786
(GO Reference Genome Project, 2011-)
inferred from sequence or structural similarity with UniProtKB:P56471
(Gene Ontology Curators, 2002-)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in mitochondrion
inferred from high throughput direct assay
(Tan et al., 2009, Alonso et al., 2005)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
part_of isocitrate dehydrogenase complex (NAD+)
inferred from sequence or structural similarity with UniProtKB:P50213
(Gene Ontology Curators, 2002-)
is_active_in mitochondrial matrix
inferred from experiment
(Ugur et al., 2017)
is_active_in mitochondrion
inferred from biological aspect of ancestor with PANTHER:PTN000216786
(GO Reference Genome Project, 2011-)
located_in mitochondrion
inferred from sequence or structural similarity with UniProtKB:P56471
(Gene Ontology Curators, 2002-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the isocitrate and isopropylmalate dehydrogenases family. (Q9VWH4)
Protein Signatures (InterPro)
Catalytic Activity (EC/Rhea)
isocitrate dehydrogenase (NAD+) activity
D-threo-isocitrate + NAD(+) = 2-oxoglutarate + CO2 + NADH (1.1.1.41)
RHEA 23632:
Summaries
Gene Group (FlyBase)
ISOCITRATE DEHYDROGENASES -
Isocitrate dehydrogenase (IDH) enzymes catalyze the oxidative decarboxylation of isocitrate to form α-ketoglutarate and contribute to the circuitry of central metabolism. Mammalian IDH1 and IDH2 are NADP-dependent enzymes that exist as homodimers and catalyze the reversible conversion of isocitrate to α-ketoglutarate. In contrast, mammalian IDH3 is a mitochondrial, NAD-dependent heterotetramer comprising two catalytic alpha subunits together with regulatory beta and gamma subunits. IDH3 strictly catalyzes the forward reaction, and is the key enzyme driving the tricarboxylic acid cycle by supplying α-ketoglutarate from the isocitrate pool. (Adapted from PMID:28375741 and PMID:28139779.)
ISOCITRATE DEHYDROGENASE COMPLEX -
The isocitrate dehydrogenase complex catalyzes the NAD-dependent oxidative decarboxylation of isocitrate to α-ketoglutarate in the rate-limiting step of the tricarboxylic acid cycle in the mitochondrial matrix. It consists of three types of subunits in the ratio of 2 alpha:1 beta:1 gamma, and exists as a heterotetramer composed of the alpha-beta and alpha-gamma heterodimers. The alpha subunit provides the catalytic activity, the gamma subunit plays a regulatory role to activate the holoenzyme, and the beta subunit has a structural role to facilitate assembly of the holoenzyme. (Adapted from PMID:28139779.)
Protein Function (UniProtKB)
Probable catalytic subunit of the enzyme which catalyzes the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate.
(UniProt, Q9VWH4)
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\Idh3a for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VWH4)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.48

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Idh3a-RA
FBtr0074780
NM_133160
1332
354
Idh3a-RC
FBtr0307904
NM_167657
2029
354
Idh3a-RD
FBtr0336668
NM_001272776
1395
377
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Idh3a-PA
FBpp0074549
38.6
354
7.42
NP_573388
AAN09496
Idh3a-PC
FBpp0300338
38.6
354
7.42
NP_728257
AAF48965
Idh3a-PD
FBpp0307649
40.8
377
7.42
Q9VWH4
NP_001259705
AGB95545
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

354 aa isoforms: Idh3a-PA, Idh3a-PC
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Heterooligomer of subunits alpha, beta, and gamma in the apparent ratio of 2:1:1 .

(UniProt, Q9VWH4)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Idh3a using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.87

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 12
anterior midgut primordium
(Fisher et al., 2012)
central brain primordium
(Fisher et al., 2012)
dorsal pharyngeal muscle primordium
(Fisher et al., 2012)
hindgut proper primordium
(Fisher et al., 2012)
Malpighian tubule primordium
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
posterior midgut primordium
(Fisher et al., 2012)
somatic muscle primordium

Comment: reported as muscle system primordium

(Fisher et al., 2012)
trunk visceral muscle primordium

Comment: reported as muscle system primordium

(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
dorsal pharyngeal muscle cell
(Fisher et al., 2012)
embryonic anal pad
(Fisher et al., 2012)
embryonic brain
(Fisher et al., 2012)
embryonic hindgut
(Fisher et al., 2012)
embryonic/larval midgut
(Fisher et al., 2012)
larval muscle system
(Fisher et al., 2012)
larval somatic muscle cell
(Fisher et al., 2012)
larval visceral muscle cell
(Fisher et al., 2012)
gastric caecum
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
larval ventral nerve cord
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in mitochondrion
inferred from high throughput direct assay
(Tan et al., 2009, Alonso et al., 2005)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Idh3a in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 9 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Idh3a
Transgenic constructs containing regulatory region of Idh3a
Aberrations (Deficiencies and Duplications) ( 8 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
lethal | pharate adult stage
lethal | pupal stage
lethal | recessive
lethal - all die before end of larval stage
lethal - all die before end of larval stage (with Idh3a1)
lethal - all die before end of larval stage (with Idh3a2)
lethal - all die before end of larval stage (with Idh3a3)
lethal - all die before end of larval stage (with Idh3a4)
lethal - all die before end of larval stage (with Idh3aG0156)
lethal - all die before end of pupal stage (with Idh3a1)
lethal - all die before end of pupal stage (with Idh3a2)
lethal - all die before end of pupal stage (with Idh3a3)
lethal - all die before end of pupal stage (with Idh3aG0156)
lethal - all die during P-stage, with Scer\GAL4Mef2.PR
lethal - all die during pupal stage, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
fertile
male fertile, with Scer\GAL4nanos.PG
Other Phenotypes
Allele
abnormal locomotor behavior | larval stage
abnormal neurophysiology | adult stage | somatic clone - tissue specific
abnormal neurophysiology | third instar larval stage
visible, with Scer\GAL4pnr-MD237
Phenotype manifest in
Allele
bouton | larval stage
capitate projection | decreased number | somatic clone - tissue specific
embryonic/larval neuromuscular junction | third instar larval stage
embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4da.G32
embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4Mef2.PU
embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4nSyb.PS
indirect flight muscle | adult stage, with Scer\GAL4Act88F.PB
larval muscle system | larval stage
mitochondrion | adult stage | somatic clone - tissue specific
mitochondrion | larval stage
myofibril | adult stage, with Scer\GAL4Act88F.PB
NMJ bouton | decreased number | third instar larval stage
optic cartridge | somatic clone - tissue specific
retina | somatic clone - tissue specific
trichogen cell, with Scer\GAL4pnr-MD237
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (5)
Hsap\IDH3A
14 of 14
Yes
Yes
1  
Hsap\IDH3G
6 of 14
No
No
Hsap\IDH3B
5 of 14
No
No
1  
Hsap\IDH1
1 of 14
No
No
Hsap\IDH2
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (6)
Rnor\Idh3a
14 of 14
Yes
Yes
Rnor\Idh3b
5 of 14
No
No
Rnor\Idh3g
5 of 14
No
No
Rnor\LOC100125384
5 of 14
No
No
Rnor\Idh1
1 of 14
No
No
Rnor\Idh2
1 of 14
No
No
Mus musculus (laboratory mouse) (6)
Mmus\Idh3a
14 of 14
Yes
Yes
Mmus\4933405O20Rik
6 of 14
No
No
Mmus\Idh3g
6 of 14
No
No
Mmus\Idh3b
4 of 14
No
No
Mmus\Idh1
1 of 14
No
No
Mmus\Idh2
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (5)
Xtro\idh3a
8 of 13
Yes
Yes
Xtro\idh3g
3 of 13
No
No
Xtro\idh3b
2 of 13
No
No
Xtro\atp8b3
1 of 13
No
No
Xtro\cbln2
1 of 13
No
Yes
Danio rerio (Zebrafish) (5)
Drer\idh3a
14 of 14
Yes
Yes
Drer\idh3g
6 of 14
No
No
Drer\idh3b
5 of 14
No
No
Drer\idh1
1 of 14
No
No
Drer\idh2
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (6)
Cele\idha-1
14 of 14
Yes
Yes
Cele\idhg-1
6 of 14
No
No
Cele\idhg-2
6 of 14
No
No
Cele\idhb-1
5 of 14
No
No
Cele\idh-1
1 of 14
No
No
Cele\idh-2
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (5)
Agam\AgaP_AGAP002728
11 of 12
Yes
Yes
Agam\AgaP_AGAP002192
5 of 12
No
No
Agam\AgaP_AGAP007786
5 of 12
No
No
Agam\AgaP_AGAP003168
1 of 12
No
No
Agam\AgaP_AGAP006660
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (13)
Atha\IDH-V
13 of 13
Yes
Yes
Atha\IDH-VI
13 of 13
Yes
Yes
Atha\IDH1
5 of 13
No
No
Atha\IDH2
5 of 13
No
No
Atha\IDH-III
5 of 13
No
No
Atha\IDH-IV
5 of 13
No
No
Atha\AT1G80555
3 of 13
No
Yes
Atha\IMD1
3 of 13
No
Yes
Atha\IMD2
3 of 13
No
Yes
Atha\IMD3
3 of 13
No
Yes
Atha\AT5G14590
1 of 13
No
No
Atha\cICDH
1 of 13
No
No
Atha\ICDH
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (7)
Scer\IDH2
13 of 13
Yes
Yes
Scer\IDH1
5 of 13
No
No
Scer\LYS12
5 of 13
No
Yes
Scer\LEU2
2 of 13
No
Yes
Scer\IDP1
1 of 13
No
No
Scer\IDP2
1 of 13
No
No
Scer\IDP3
1 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (5)
Spom\idh2
12 of 12
Yes
Yes
Spom\SPAC31G5.04
5 of 12
No
Yes
Spom\idh1
4 of 12
No
No
Spom\leu1
2 of 12
No
Yes
Spom\idp1
1 of 12
No
No
Escherichia coli (enterobacterium) (3)
Ecol\dmlA
6 of 11
Yes
Yes
Ecol\icd
6 of 11
Yes
Yes
Ecol\leuB
3 of 11
No
Yes
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Idh3a. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (6)
CG32026
11 of 13
CG3483
10 of 13
Idh3g
10 of 13
Idh3b
9 of 13
CG7755
5 of 13
Idh
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Allele
Disease
Evidence
References
Idh3a1
model of  neuromuscular junction disease
CEA
(Ugur et al., 2017)
Potential Models Based on Orthology ( 1 )
Modifiers Based on Experimental Evidence ( 2 )
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
IDH3A; isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha
14 of 14
601149
 
IDH3G; isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma
6 of 14
300089
      IDH3B; isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta
      5 of 14
      604526
       
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Interactions
      Summary of Physical Interactions
      esyN Network Diagram
      Show neighbor-neighbor interactions:
      Show/hide secondary interactors 
      (data from AllianceMine provided by esyN)
      Select Layout:
      Legend:
      Protein
      RNA
      Selected Interactor(s)
      Other Interaction Browsers
      View in FlyBase Interactions Browser   View in MIST tool (external link)
      Please see the Physical Interaction reports below for full details
      protein-protein
      Physical Interaction
      Assay
      References
      Idh3a - Actn
      experimental knowledge based
      (Guruharsha et al., 2011)
      Idh3a - Agpat3
      experimental knowledge based
      (Guruharsha et al., 2011)
      Idh3a - Argk1
      experimental knowledge based
      (Guruharsha et al., 2011)
      Idh3a - CCT3
      experimental knowledge based
      (Guruharsha et al., 2011)
      Idh3a - CCT4
      experimental knowledge based
      (Guruharsha et al., 2011)
      Idh3a - CCT6
      experimental knowledge based
      (Guruharsha et al., 2011)
      Idh3a - CCT7
      experimental knowledge based
      (Guruharsha et al., 2011)
      Idh3a - CCT8
      experimental knowledge based
      (Guruharsha et al., 2011)
      Idh3a - CG1371
      experimental knowledge based
      (Guruharsha et al., 2011)
      Idh3a - CG2065
      experimental knowledge based
      (Guruharsha et al., 2011)
      Idh3a - CG3008
      experimental knowledge based
      (Guruharsha et al., 2011)
      Idh3a - CG31729
      experimental knowledge based
      (Guruharsha et al., 2011)
      Idh3a - CG33303
      experimental knowledge based
      (Guruharsha et al., 2011)
      Idh3a - CG5854
      experimental knowledge based
      (Guruharsha et al., 2011)
      Idh3a - CG9467
      experimental knowledge based
      (Guruharsha et al., 2011)
      Idh3a - Chc
      experimental knowledge based
      (Guruharsha et al., 2011)
      Idh3a - Cnx99A
      experimental knowledge based
      (Guruharsha et al., 2011)
      Idh3a - Cyp12d1-p
      experimental knowledge based
      (Guruharsha et al., 2011)
      Idh3a - Cyt-c1
      experimental knowledge based
      (Guruharsha et al., 2011)
      Idh3a - Etfb
      experimental knowledge based
      (Guruharsha et al., 2011)
      Idh3a - Fatp1
      experimental knowledge based
      (Guruharsha et al., 2011)
      Idh3a - Gfat2
      experimental knowledge based
      (Guruharsha et al., 2011)
      Idh3a - Glt
      experimental knowledge based
      (Guruharsha et al., 2011)
      Idh3a - GluProRS
      experimental knowledge based
      (Guruharsha et al., 2011)
      Idh3a - Gp210
      experimental knowledge based
      (Guruharsha et al., 2011)
      Idh3a - Gp93
      experimental knowledge based
      (Guruharsha et al., 2011)
      Idh3a - Idh3g
      experimental knowledge based
      (Guruharsha et al., 2011)
      Idh3a - Ipo9
      experimental knowledge based
      (Guruharsha et al., 2011)
      Idh3a - Kap-α3
      experimental knowledge based
      (Guruharsha et al., 2011)
      Idh3a - Karyβ3
      experimental knowledge based
      (Guruharsha et al., 2011)
      Idh3a - Kdsr
      experimental knowledge based
      (Guruharsha et al., 2011)
      Idh3a - Kr-h2
      experimental knowledge based
      (Guruharsha et al., 2011)
      Idh3a - MRP
      experimental knowledge based
      (Guruharsha et al., 2011)
      Idh3a - Mcad
      experimental knowledge based
      (Guruharsha et al., 2011)
      Idh3a - Mpcp2
      experimental knowledge based
      (Guruharsha et al., 2011)
      Idh3a - Nacα
      experimental knowledge based
      (Guruharsha et al., 2011)
      Idh3a - Nfs1
      experimental knowledge based
      (Guruharsha et al., 2011)
      Idh3a - Ost48
      experimental knowledge based
      (Guruharsha et al., 2011)
      Idh3a - OstΔ
      experimental knowledge based
      (Guruharsha et al., 2011)
      Idh3a - Past1
      experimental knowledge based
      (Guruharsha et al., 2011)
      Idh3a - Pcb
      experimental knowledge based
      (Guruharsha et al., 2011)
      Idh3a - Pi3K68D
      experimental knowledge based
      (Guruharsha et al., 2011)
      Idh3a - Pih1D1
      experimental knowledge based
      (Guruharsha et al., 2011)
      Idh3a - Pp2A-29B
      experimental knowledge based
      (Guruharsha et al., 2011)
      Idh3a - Prm
      experimental knowledge based
      (Guruharsha et al., 2011)
      Idh3a - Rab5
      experimental knowledge based
      (Guruharsha et al., 2011)
      Idh3a - Rdh1
      experimental knowledge based
      (Guruharsha et al., 2011)
      Idh3a - RpLP0
      experimental knowledge based
      (Guruharsha et al., 2011)
      Idh3a - RpS10b
      experimental knowledge based
      (Guruharsha et al., 2011)
      Idh3a - RpS5a
      experimental knowledge based
      (Guruharsha et al., 2011)
      Idh3a - Rpt1
      experimental knowledge based
      (Guruharsha et al., 2011)
      Idh3a - Rpt6
      experimental knowledge based
      (Guruharsha et al., 2011)
      Idh3a - SERCA
      experimental knowledge based
      (Guruharsha et al., 2011)
      Idh3a - ScsβA
      experimental knowledge based
      (Guruharsha et al., 2011)
      Idh3a - ScsβG
      experimental knowledge based
      (Guruharsha et al., 2011)
      Idh3a - Sec61α
      experimental knowledge based
      (Guruharsha et al., 2011)
      Idh3a - Sec63
      experimental knowledge based
      (Guruharsha et al., 2011)
      Idh3a - SerRS
      experimental knowledge based
      (Guruharsha et al., 2011)
      Idh3a - Spindly
      experimental knowledge based
      (Guruharsha et al., 2011)
      Idh3a - TER94
      experimental knowledge based
      (Guruharsha et al., 2011)
      Idh3a - Tapδ
      experimental knowledge based
      (Guruharsha et al., 2011)
      Idh3a - Tecr
      experimental knowledge based
      (Guruharsha et al., 2011)
      Idh3a - Tm2
      experimental knowledge based
      (Guruharsha et al., 2011)
      Idh3a - UQCR-6.4
      experimental knowledge based
      (Guruharsha et al., 2011)
      Idh3a - UQCR-C2
      experimental knowledge based
      (Guruharsha et al., 2011)
      Idh3a - Vps4
      experimental knowledge based
      (Guruharsha et al., 2011)
      Idh3a - boca
      experimental knowledge based
      (Guruharsha et al., 2011)
      Idh3a - bor
      experimental knowledge based
      (Guruharsha et al., 2011)
      Idh3a - cPges
      experimental knowledge based
      (Guruharsha et al., 2011)
      Idh3a - fax
      experimental knowledge based
      (Guruharsha et al., 2011)
      Idh3a - lic
      experimental knowledge based
      (Guruharsha et al., 2011)
      Idh3a - mEFTu1
      experimental knowledge based
      (Guruharsha et al., 2011)
      Idh3a - r
      experimental knowledge based
      (Guruharsha et al., 2011)
      Idh3a - scf
      experimental knowledge based
      (Guruharsha et al., 2011)
      Idh3a - wal
      experimental knowledge based
      (Guruharsha et al., 2011)
      Idh3a - α-Spec
      experimental knowledge based
      (Guruharsha et al., 2011)
      Idh3a - βCOP
      experimental knowledge based
      (Guruharsha et al., 2011)
      Summary of Genetic Interactions
      esyN Network Diagram
      Other Interaction Browsers
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      External Data
      Subunit Structure (UniProtKB)
      Heterooligomer of subunits alpha, beta, and gamma in the apparent ratio of 2:1:1 .
      (UniProt, Q9VWH4 )
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Pathways
      Signaling Pathways (FlyBase)
      Metabolic Pathways
      FlyBase
      External Links
      FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel
      KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.
      Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.
      External Data
      Linkouts
      KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
      Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
      Class of Gene
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      X
      Recombination map
      1-62
      Cytogenetic map
      18C8-18C8
      Sequence location
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      18C8-18C8
      Limits computationally determined from genome sequence between P{EP}EP1526&P{EP}PfrxEP1150 and P{EP}Tao-1EP1455
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      18D1-18D4
      (determined by in situ hybridisation)
      (Peter et al., 2002, Schäfer et al., 1999.6.15)
      Experimentally Determined Recombination Data
      Location

      1-62

      (FlyBase, 2016)

      1-62.1

      (Comeron et al., 2012)
      Left of (cM)
      Right of (cM)
      Notes
      Stocks and Reagents
      Stocks (11)
      Genomic Clones (21)
      cDNA Clones (153)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequenced
      BDGP DGC clones
      Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      Antibody Information
      Laboratory Generated Antibodies
       
      Commercially Available Antibodies
       
      Cell Line Information
      Publicly Available Cell Lines
       
        Other Stable Cell Lines
         
          Other Comments
          Relationship to Other Genes
          Source for database merge of

          Source for merge of: l(1)G0156 CG12233

          (Peter et al., 2002)
          Additional comments
          Nomenclature History
          Source for database identify of

          Source for identity of: Idh3a l(1)G0156

          (Ugur et al., 2017)
          Nomenclature comments
          Etymology

          Named 'idh3a' because it's a homolog of human mitochondrial IDH3A.

          (Ugur et al., 2017)
          Synonyms and Secondary IDs (13)
          Datasets (0)
          Study focus (0)
          Experimental Role
          Project
          Project Type
          Title
          Study result (0)
          Result
          Result Type
          Title
          External Crossreferences and Linkouts ( 54 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
          UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
          Other crossreferences
          AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
          DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
          EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
          FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
          FlyMine - An integrated database for Drosophila genomics
          InterPro - A database of protein families, domains and functional sites
          KEGG Genes - Molecular building blocks of life in the genomic space.
          MARRVEL_MODEL - MARRVEL (model organism gene)
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
          DroID - A comprehensive database of gene and protein interactions.
          DRSC - Results frm RNAi screens
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
          FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          Flygut - An atlas of the Drosophila adult midgut
          FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
          KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.
          KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.
          References (89)