FlyBase Gene Report: Dmel\CCT6

CHAPERONIN CONTAINING TCP-1 COMPLEX -: Group II Heat Shock Protein 60 chaperonins are paralogous subunits that assemble to form a multi-subunit ring complex, the TCP-1 Ring Complex (TRiC) or Chaperonin Containing TCP-1 (CCT) complex. Within the cytoplasm, TRiC/CCT catalyses the ATP-dependent folding of approximately 10% of of newly synthesized proteins. (Adapted from FBrf0210519, FBrf0232269 and PMID:11580267).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the GBrowse view of Dmel\CCT6 or the JBrowse view of Dmel\CCT6 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.43

Gene model reviewed during 5.50

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

CCT6-RA

FBtr0074086

NM_132838

1924

533

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

CCT6-PA

FBpp0073902

58.2

533

6.60

NP_573066

AAF48503

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9VXQ5

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CCT6 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Tcp-1zeta_1

Linkouts

Gene Ontology (6 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

ATP binding

inferred from electronic annotation with InterPro:IPR002194, InterPro:IPR002423, InterPro:IPR012722

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

unfolded protein binding

inferred from electronic annotation with InterPro:IPR002194, InterPro:IPR012722

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

Biological Process (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

centriole replication

inferred from mutant phenotype

(Dobbelaere et al., 2008)

mitotic cell cycle

inferred from high throughput mutant phenotype

(Ducat et al., 2008)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

protein folding

inferred from electronic annotation with InterPro:IPR002194, InterPro:IPR012722

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

chaperonin-containing T-complex

inferred from biological aspect of ancestor with PANTHER:PTN000143755

(assigned by GO_Central )

(Gaudet et al., 2011)

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

pole plasm

Comment: maternally deposited

(Fisher et al., 2012)

organism

• pole plasm

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | ubiquitous

(Fisher et al., 2012)

pole cell

(Fisher et al., 2012)

embryonic stage 7 -- 8

anterior endoderm anlage

(Fisher et al., 2012)

head mesoderm

(Fisher et al., 2012)

pole cell

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

embryonic stage 9 -- 10

anterior endoderm

(Fisher et al., 2012)

germline cell

(Fisher et al., 2012)

head mesoderm

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

embryonic stage 11 -- 12

anterior midgut primordium

(Fisher et al., 2012)

dorsal pharyngeal muscle primordium

(Fisher et al., 2012)

hindgut proper primordium

(Fisher et al., 2012)

posterior midgut primordium

(Fisher et al., 2012)

somatic muscle primordium

Comment: reported as muscle system primordium

(Fisher et al., 2012)

visceral muscle primordium

Comment: reported as muscle system primordium

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

embryonic stage 13 -- 16

dorsal pharyngeal muscle

(Fisher et al., 2012)

embryonic hindgut

(Fisher et al., 2012)

embryonic large intestine

(Fisher et al., 2012)

embryonic Malpighian tubule

(Fisher et al., 2012)

embryonic/larval midgut

(Fisher et al., 2012)

embryonic/larval muscle system

(Fisher et al., 2012)

embryonic/larval somatic muscle

(Fisher et al., 2012)

embryonic/larval visceral muscle

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

day 7 of adulthood -- day 49 of adulthood

adult heart

(Cammarato et al., 2011)

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\CCT6 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\CCT6

View exonic expression by tissue for Dmel\CCT6

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0027329

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0027329

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG8231-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG8231

Flygut - An atlas of the Drosophila adult midgut

FBgn0027329

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\CCT6

Stages(s) 4-6
Stages(s) 7-8
Stages(s) 9-10
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 5 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 5 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of CCT6

Transgenic constructs containing regulatory region of CCT6

Deletions and Duplications ( 2 )

Disrupted in

Df(1)Exel6250

(Ryder, 2004.4.26)

Duplicated in

Dp(1;3)DC305

(Popodi et al., 2010-, Venken et al., 2010)

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^pnr-MD237

CCT6^GD13776

lethal | pharate adult stage

CCT6^G0022

lethal | pupal stage

CCT6^G0022

lethal | recessive

lethal - all die before end of larval stage

lethal - all die during larval stage, with Scer\GAL4^Mef2.PR

CCT6^GD13776

lethal - all die during pharate adult stage, with Scer\GAL4^ey.PU

partially lethal - majority die | recessive

CCT6^G0022

Other Phenotypes

Allele

short lived, with Scer\GAL4^HCH.Hand

short lived, with Scer\GAL4^tin.CΔ4

some die during immature adult stage | recessive, with Scer\GAL4^pnr-MD237

CCT6^GD13776

some die during larval stage

visible | pharate adult stage, with Scer\GAL4^ey.PU

Phenotype manifest in

Allele

adult head | pharate adult stage, with Scer\GAL4^ey.PU

adult heart

CCT6^G0022

adult heart, with Scer\GAL4^HCH.Hand

adult heart | progressive, with Scer\GAL4^tin.CΔ4

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v7.1)

Homo sapiens (Human) (13)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\CCT6A

13 of 15

Yes

Hsap\CCT6B

12 of 15

Yes

2 of 15

2 of 15

2 of 15

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Hsap\TCP1

1 of 15

Hsap\VKORC1L1

1 of 15

Model Organism Orthologs (via DIOPT v7.1)

Mus musculus (laboratory mouse) (12)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Cct6a

13 of 15

Yes

Mmus\Cct6b

12 of 15

Yes

Mmus\Cct4

2 of 15

Mmus\Cct5

2 of 15

Mmus\Bbs10

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Mmus\Tcp1

1 of 15

Rattus norvegicus (Norway rat) (12)

Rnor\Cct6b

12 of 13

Yes

Rnor\Cct6a

11 of 13

Yes

2 of 13

2 of 13

2 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Rnor\Tcp1

1 of 13

Xenopus tropicalis (Western clawed frog) (8)

Xtro\cct6a

9 of 12

Yes

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Danio rerio (Zebrafish) (11)

Drer\cct6a

11 of 15

Yes

2 of 15

2 of 15

2 of 15

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Drer\tcp1

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (8)

Cele\cct-6

12 of 15

Yes

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Arabidopsis thaliana (thale-cress) (2)

Atha\AT3G02530

9 of 9

Yes

Atha\AT5G16070

9 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (9)

Scer\CCT6

13 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\cct6

11 of 12

Yes

Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG0919074S )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA27623

Drosophila pseudoobscura pseudoobscura

Dpse\GA26183

Drosophila persimilis

Dper\GL12072

Drosophila willistoni

Dwil\GK10099

Drosophila virilis

Dvir\T-cp1

Drosophila mojavensis

Dmoj\GI14661

Drosophila grimshawi

Dgri\GH24158

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091503FB )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17008434

Glossina morsitans

Tsetse fly

Gmor\GMOY003024

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_08257

Mayetiola destructor

Hessian fly

Mdes\Mdes009309

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL006946

Anopheles darlingi

American malaria mosquito

Adar\ADAC010601

Anopheles gambiae

Malaria mosquito

Agam\AGAP003477

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ003543

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W04C9 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA013116

Danaus plexippus

Monarch butterfly

Dple\DPOGS201820-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL008338

Apis florea

Little honeybee

Aflo\4120915684

Apis mellifera

Western honey bee

Amel\GB46263

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP23761

Bombus terrestris

Buff-tailed bumblebee

Bter\15205758

Linepithema humile

Argentine ant

Lhum\LH25055

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:0014c2

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG014437

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_11672

Tribolium castaneum

Red flour beetle

Tcas\GLEAN_15375-OG7291

Pediculus humanus

Human body louse

Phum\PHUM322090

Rhodnius prolixus

Kissing bug

Rpro\RPRC014718

Cimex lectularius

Bed bug

Clec\CLEC001423

Cimex lectularius

Bed bug

Clec\CLEC003465

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI000575

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_07990

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X048Y )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR002653

Ixodes scapularis

Black-legged tick

Isca\ISCW008709

Stegodyphus mimosarum

African social velvet spider

Smim\KFM69666.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur05g09090

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_306375

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G07CE )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Cct6A_1

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Cct6A

Ciona intestinalis

Vase tunicate

Cint\LOC101242528

Gallus gallus

Domestic chicken

Ggal\CCT6

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v7.1)

Drosophila melanogaster (Fruit fly) (12)

Gene Symbol

Score

Source

Alignment

4 of 10

4 of 10

4 of 10

3 of 10

3 of 10

3 of 10

3 of 10

2 of 10

2 of 10

2 of 10

2 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

cardiac dysfunction (postulated), TRiC/CCT complex

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 3 )

Allele

Disease

Evidence

References

CCT6^G0022

model of intrinsic cardiomyopathy

CEA

(Melkani et al., 2017)

CCT6^GD13776

model of intrinsic cardiomyopathy

CEA

(Melkani et al., 2017)

CCT6^KK108596

model of intrinsic cardiomyopathy

CEA

(Melkani et al., 2017)

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

CCT6A; chaperonin containing TCP1 subunit 6A

13 of 15

104613

CCT6B; chaperonin containing TCP1 subunit 6B

12 of 15

610730

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

CCT6 - ATPsynγ

experimental knowledge based

(Guruharsha et al., 2011)

CCT6 - Akt1

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

CCT6 - Arf79F

experimental knowledge based

(Guruharsha et al., 2011)

CCT6 - Arl8

experimental knowledge based

(Guruharsha et al., 2011)

CCT6 - AsnRS

experimental knowledge based

(Guruharsha et al., 2011)

CCT6 - CCT1

experimental knowledge based

(Guruharsha et al., 2011)

CCT6 - CCT2

experimental knowledge based

(Guruharsha et al., 2011)

CCT6 - CCT3

experimental knowledge based

(Guruharsha et al., 2011)

CCT6 - CCT4

experimental knowledge based

(Guruharsha et al., 2011)

CCT6 - CCT5

experimental knowledge based

(Guruharsha et al., 2011)

CCT6 - CCT7

experimental knowledge based

(Guruharsha et al., 2011)

CCT6 - CCT8

experimental knowledge based

(Guruharsha et al., 2011)

CCT6 - CG1416

experimental knowledge based

(Guruharsha et al., 2011)

CCT6 - CG2064

experimental knowledge based

(Guruharsha et al., 2011)

CCT6 - CG33303

experimental knowledge based

(Guruharsha et al., 2011)

CCT6 - CG5854

experimental knowledge based

(Guruharsha et al., 2011)

CCT6 - Chc

experimental knowledge based

(Guruharsha et al., 2011)

CCT6 - Cnx99A

experimental knowledge based

(Guruharsha et al., 2011)

CCT6 - Cyp12d1-p

experimental knowledge based

(Guruharsha et al., 2011)

CCT6 - Dredd

anti tag coimmunoprecipitation, peptide massfingerprinting

(Fukuyama et al., 2012)

CCT6 - Droj2

experimental knowledge based

(Guruharsha et al., 2011)

CCT6 - FASN1

experimental knowledge based

(Guruharsha et al., 2011)

CCT6 - GCS2β

experimental knowledge based

(Guruharsha et al., 2011)

CCT6 - Gale

experimental knowledge based

(Guruharsha et al., 2011)

CCT6 - Gfat2

experimental knowledge based

(Guruharsha et al., 2011)

CCT6 - GluProRS

experimental knowledge based

(Guruharsha et al., 2011)

CCT6 - Gp93

experimental knowledge based

(Guruharsha et al., 2011)

CCT6 - Hel25E

experimental knowledge based

(Guruharsha et al., 2011)

CCT6 - Idh3a

experimental knowledge based

(Guruharsha et al., 2011)

CCT6 - Kap-α3

experimental knowledge based

(Guruharsha et al., 2011)

CCT6 - Kr-h2

experimental knowledge based

(Guruharsha et al., 2011)

CCT6 - Ldh

experimental knowledge based

(Guruharsha et al., 2011)

CCT6 - Lst8

anti tag coimmunoprecipitation, peptide massfingerprinting

(Glatter et al., 2011)

CCT6 - MRP

experimental knowledge based

(Guruharsha et al., 2011)

CCT6 - Mcad

experimental knowledge based

(Guruharsha et al., 2011)

CCT6 - Mec2

experimental knowledge based

(Guruharsha et al., 2011)

CCT6 - Mer

anti tag coimmunoprecipitation, peptide massfingerprinting

(Kwon et al., 2013)

CCT6 - Mpcp2

experimental knowledge based

(Guruharsha et al., 2011)

CCT6 - Nfs1

experimental knowledge based

(Guruharsha et al., 2011)

CCT6 - Ost48

experimental knowledge based

(Guruharsha et al., 2011)

CCT6 - OstΔ

experimental knowledge based

(Guruharsha et al., 2011)

CCT6 - PCB

experimental knowledge based

(Guruharsha et al., 2011)

CCT6 - Past1

experimental knowledge based

(Guruharsha et al., 2011)

CCT6 - Pdk1

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

CCT6 - Pp2A-29B

experimental knowledge based

(Guruharsha et al., 2011)

CCT6 - Psa

experimental knowledge based

(Guruharsha et al., 2011)

CCT6 - Rab2

experimental knowledge based

(Guruharsha et al., 2011)

CCT6 - Rab5

experimental knowledge based

(Guruharsha et al., 2011)

CCT6 - Rab7

experimental knowledge based

(Guruharsha et al., 2011)

CCT6 - Ranbp9

experimental knowledge based

(Guruharsha et al., 2011)

CCT6 - Rap2l

experimental knowledge based

(Guruharsha et al., 2011)

CCT6 - RpS10b

experimental knowledge based

(Guruharsha et al., 2011)

CCT6 - Rpt1

experimental knowledge based

(Guruharsha et al., 2011)

CCT6 - Rpt2

experimental knowledge based

(Guruharsha et al., 2011)

CCT6 - Rpt4

experimental knowledge based

(Guruharsha et al., 2011)

CCT6 - Rpt5

experimental knowledge based

(Guruharsha et al., 2011)

CCT6 - Rpt6

experimental knowledge based

(Guruharsha et al., 2011)

CCT6 - SERCA

experimental knowledge based

(Guruharsha et al., 2011)

CCT6 - ScsβA

experimental knowledge based

(Guruharsha et al., 2011)

CCT6 - ScsβG

experimental knowledge based

(Guruharsha et al., 2011)

CCT6 - SerRS

experimental knowledge based

(Guruharsha et al., 2011)

CCT6 - Tapδ

experimental knowledge based

(Guruharsha et al., 2011)

CCT6 - Tspo

experimental knowledge based

(Guruharsha et al., 2011)

CCT6 - UQCR-C2

experimental knowledge based

(Guruharsha et al., 2011)

CCT6 - Vha68-2

experimental knowledge based

(Guruharsha et al., 2011)

CCT6 - cathD

experimental knowledge based

(Guruharsha et al., 2011)

CCT6 - foxo

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

CCT6 - mEFTu1

experimental knowledge based

(Guruharsha et al., 2011)

CCT6 - mst

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Palumbo et al., 2015)

CCT6 - shd

experimental knowledge based

(Guruharsha et al., 2011)

CCT6 - sima

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

CCT6 - spidey

experimental knowledge based

(Guruharsha et al., 2011)

CCT6 - wal

experimental knowledge based

(Guruharsha et al., 2011)

CCT6 - wts

anti tag coimmunoprecipitation, peptide massfingerprinting

(Kwon et al., 2013)

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

58868

DroID - A comprehensive database of gene and protein interactions.

FBgn0027329

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

32518

MIST (protein-protein) - An integrated Molecular Interaction Database

Tcp-1zeta

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-51

Cytogenetic map

13E13-13E14

Sequence location

X:15,746,648..15,748,971 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

13E13-13E14

Limits computationally determined from genome sequence between P{EP}EP1489 and P{EP}BEST:RE35685^EP1581&P{EP}sd^EP1088

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

13F1-13F2

(determined by in situ hybridisation) 13E7--15 (determined by in situ hybridisation)

(Peter et al., 2002)

13F1-13F2

(determined by in situ hybridisation) 13E8--15 (determined by in situ hybridisation) 13E7--15 (determined by in situ hybridisation)

(Schäfer et al., 1999.6.15)

13F1-13F2

(determined by in situ hybridisation)

(Schäfer et al., 1999.3.29)

Experimentally Determined Recombination Data

Location

1-51

(FlyBase, 2016)

1-51.9

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (6)

Bloomington

11475

w^67c23 P{lacW}CCT6^G0022/FM7c

43146

y¹ v¹; P{TRiP.GL01487}attP40

21199

y¹ w^67c23 P{EPgy2}CCT6^EY16253/FM7c, sn⁺

Kyoto

111838

y¹ w^* P{lacW}CCT6^G0027 P{neoFRT}19A/FM7c; P{ey-FLP.N}5

VDRC

v109734

P{KK108596}VIE-260B

v23751

w¹¹¹⁸; P{GD13776}v23751/CyO

Genomic Clones (11)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (123)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequences

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0027329

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0027329

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

32518

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: Tcp-1ζ l(1)G0022

(Goshima et al., 2007)

Source for identity of: CCT6 Tcp-1ζ

(Monzo et al., 2010)

Source for database merge of

Source for merge of: l(1)G0022 CG8231 l(1)G0027 l(1)G0057

(Peter et al., 2002)

Additional comments

FlyBase curator comment: Renamed from 'Tcp-1ζ' to 'CCT6' to unify the nomenclature used for the CCT/TRiC subunits in FlyBase, following the nomenclature used in this paper (FBrf0210519) and other species.

(Monzo et al., 2010)

Other Comments

Tcp-1ζ is involved in centriole duplication and is required for efficient recruitment of pericentriolar material.

(Dobbelaere et al., 2008)

RNAi screen using dsRNA made from templates generated with primers directed against this gene in S2 cell results in dim staining of microtubules, and a short monopolar spindle. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA.

(Goshima et al., 2007)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 39 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

32518

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q9VXQ5

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0027329

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0027329

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Tcp-1zeta_1

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG8231

Flygut - An atlas of the Drosophila adult midgut

FBgn0027329

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

32518

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG8231

modMine - A data warehouse for the modENCODE project

FBgn0027329

Linkouts

BioGRID - A database of protein and genetic interactions.

58868

DPiM - Drosophila Protein interaction map

FBgn0027329

DroID - A comprehensive database of gene and protein interactions.

FBgn0027329

DRSC - Results frm RNAi screens

FBgn0027329

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0027329

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG8231-RA

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0027329

FlyMine - An integrated database for Drosophila genomics

FBgn0027329

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

32518

MIST (protein-protein) - An integrated Molecular Interaction Database

Tcp-1zeta

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synonyms and Secondary IDs (22)

Reported As

Symbol Synonym

CCT6

(Kim and Choi, 2019, Kurshakova et al., 2019, Monzo et al., 2010)

CG8231

(Kolkhof et al., 2017, Çiçek et al., 2016, Hosono et al., 2015, Moutinho-Pereira et al., 2013, Cammarato et al., 2011, Glatter et al., 2011, Monzo et al., 2010, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Dobbelaere et al., 2008, Ducat et al., 2008, Hughes et al., 2008, Domanitskaya et al., 2007, Goshima et al., 2007, Stuart et al., 2007, Cermelli et al., 2006)

Cct6

(Melkani et al., 2017)

L(1)g0022

(Bandyopadhyay et al., 2006)

Q9VXQ5_DROME

(Fukuyama et al., 2012)

Rcd3

(Dobbelaere et al., 2008)

TCP-1-ζ

(Ducat et al., 2008)

TCP-1ζ

(Moutinho-Pereira et al., 2013, Monzo et al., 2010)

TCP1-zeta

(Palumbo et al., 2015)

TCP1ζ

(Álvarez-Fernández et al., 2015)

TCPzeta

(Völker-Albert et al., 2016)

Tcp-1-zeta

(Goshima et al., 2007)

Tcp-1zeta

(Dent et al., 2015, Gill et al., 2015, Beckett et al., 2013, Kwon et al., 2013, Kwon et al., 2013, Friedman et al., 2011, Popodi et al., 2010-, Venken et al., 2010, Fisher et al., 2008)

Tcp-1ζ

(Chen et al., 2014, Kallappagoudar et al., 2010)

l(1)G0022

(Cermelli et al., 2006)

l(1)G0027

(Schäfer et al., 1999.6.15)

l(1)G0057

(Schäfer et al., 1999.3.29, Schäfer et al., 1999.6.15)

Name Synonyms

Chaperonin containing TCP1 subunit 6

Lethal (1) G0022

(Ducat et al., 2008)

Reduction in Cnn Dots 3

(Dobbelaere et al., 2008)

T-cp1ζ

(Monzo et al., 2010)

lethal (1) G0022

(Cammarato et al., 2011)

Secondary FlyBase IDs

FBgn0026695
FBgn0027326
FBgn0030681

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (70)

Report Sections

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