FB2022_02, released March 29, 2022

Gene: Dmel\CCT6

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General Information
Symbol
Dmel\CCT6
Species
D. melanogaster
Name
Chaperonin containing TCP1 subunit 6
Annotation Symbol
CG8231
Feature Type
protein_coding_gene
FlyBase ID
FBgn0027329
Gene Model Status
Current
Stock Availability
6 publicly available
Gene Summary
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

Tcp-1zeta, l(1)G0057, Tcp-1ζ, l(1)G0022, T-cp1ζ

Key Links
Genomic Location
Cytogenetic map
13E13-13E14
Sequence location
Recombination map
1-51
RefSeq locus
NC_004354 REGION:15746648..15748971
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (8 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
enables ATP binding
inferred from electronic annotation with InterPro:IPR002194, InterPro:IPR002423, InterPro:IPR012722
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
enables ATP hydrolysis activity
inferred from electronic annotation with InterPro:IPR002194, InterPro:IPR002423, InterPro:IPR012722
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
enables ATP-dependent protein folding chaperone
inferred from electronic annotation with InterPro:IPR017998
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
enables unfolded protein binding
inferred from biological aspect of ancestor with PANTHER:PTN004253040
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
involved_in centriole replication
inferred from mutant phenotype
(Dobbelaere et al., 2008)
involved_in mitotic cell cycle
inferred from high throughput mutant phenotype
(Ducat et al., 2008)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in protein folding
inferred from biological aspect of ancestor with PANTHER:PTN004253040
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
part_of chaperonin-containing T-complex
inferred from biological aspect of ancestor with PANTHER:PTN000143755
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
CHAPERONIN CONTAINING TCP-1 COMPLEX -
Group II Heat Shock Protein 60 chaperonins are paralogous subunits that assemble to form a multi-subunit ring complex, the TCP-1 Ring Complex (TRiC) or Chaperonin Containing TCP-1 (CCT) complex. Within the cytoplasm, TRiC/CCT catalyses the ATP-dependent folding of approximately 10% of of newly synthesized proteins. (Adapted from FBrf0210519, FBrf0232269 and PMID:11580267).
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\CCT6 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure New Section
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VXQ5)

If you don't see the viewer to the right, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Gene model reviewed during 5.43

Gene model reviewed during 5.50

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
CCT6-RA
FBtr0074086
NM_132838
1924
533
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
CCT6-PA
FBpp0073902
58.2
533
6.60
NP_573066
AAF48503
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CCT6 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
pole plasm

Comment: maternally deposited

(Fisher et al., 2012)
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
primordial germ cell
(Fisher et al., 2012)
embryonic stage 7 -- 8
anterior endoderm anlage
(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
primordial germ cell
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
embryonic stage 9 -- 10
anterior endoderm
(Fisher et al., 2012)
germline cell
(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
embryonic stage 11 -- 12
anterior midgut primordium
(Fisher et al., 2012)
dorsal pharyngeal muscle primordium
(Fisher et al., 2012)
hindgut proper primordium
(Fisher et al., 2012)
posterior midgut primordium
(Fisher et al., 2012)
somatic muscle primordium

Comment: reported as muscle system primordium

(Fisher et al., 2012)
visceral muscle primordium

Comment: reported as muscle system primordium

(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
embryonic stage 13 -- 16
dorsal pharyngeal muscle cell
(Fisher et al., 2012)
embryonic hindgut
(Fisher et al., 2012)
embryonic large intestine
(Fisher et al., 2012)
embryonic Malpighian tubule
(Fisher et al., 2012)
embryonic/larval midgut
(Fisher et al., 2012)
embryonic/larval muscle system
(Fisher et al., 2012)
embryonic/larval somatic muscle cell
(Fisher et al., 2012)
embryonic/larval visceral muscle cell
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\CCT6 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 5 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of CCT6
Transgenic constructs containing regulatory region of CCT6
Aberrations (Deficiencies and Duplications) ( 2 )
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (13)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\CCT6A
13 of 15
Yes
Yes
Hsap\CCT6B
12 of 15
No
Yes
Hsap\CCT3
2 of 15
No
No
Hsap\CCT4
2 of 15
No
No
1  
Hsap\CCT5
2 of 15
No
No
Hsap\BBS10
1 of 15
No
Yes
Hsap\CCT2
1 of 15
No
No
Hsap\CCT7
1 of 15
No
No
Hsap\CCT8
1 of 15
No
No
Hsap\HSPD1
1 of 15
No
No
Hsap\MKKS
1 of 15
No
Yes
Hsap\TCP1
1 of 15
No
No
Hsap\VKORC1L1
1 of 15
No
No
1  
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (12)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Cct6a
13 of 15
Yes
Yes
Mmus\Cct6b
12 of 15
No
Yes
Mmus\Cct4
2 of 15
No
No
Mmus\Cct5
2 of 15
No
No
Mmus\Bbs10
1 of 15
No
Yes
Mmus\Cct2
1 of 15
No
No
Mmus\Cct3
1 of 15
No
No
Mmus\Cct7
1 of 15
No
No
Mmus\Cct8
1 of 15
No
No
Mmus\Hspd1
1 of 15
No
No
Mmus\Mkks
1 of 15
No
Yes
Mmus\Tcp1
1 of 15
No
No
Rattus norvegicus (Norway rat) (12)
Rnor\Cct6b
12 of 13
Yes
Yes
Rnor\Cct6a
11 of 13
No
Yes
Rnor\Cct3
2 of 13
No
No
Rnor\Cct4
2 of 13
No
No
Rnor\Cct5
2 of 13
No
No
Rnor\Bbs10
1 of 13
No
Yes
Rnor\Cct2
1 of 13
No
No
Rnor\Cct7
1 of 13
No
No
Rnor\Cct8
1 of 13
No
No
Rnor\Hspd1
1 of 13
No
No
Rnor\Mkks
1 of 13
No
Yes
Rnor\Tcp1
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (8)
Xtro\cct6a
9 of 12
Yes
Yes
Xtro\cct3
2 of 12
No
No
Xtro\cct4
2 of 12
No
No
Xtro\cct5
2 of 12
No
No
Xtro\cct2
1 of 12
No
No
Xtro\cct7
1 of 12
No
No
Xtro\cct8
1 of 12
No
No
Xtro\hspd1
1 of 12
No
No
Danio rerio (Zebrafish) (11)
Drer\cct6a
11 of 15
Yes
Yes
Drer\cct3
2 of 15
No
No
Drer\cct4
2 of 15
No
No
Drer\cct5
2 of 15
No
No
Drer\bbs10
1 of 15
No
Yes
Drer\cct2
1 of 15
No
No
Drer\cct7
1 of 15
No
No
Drer\cct8
1 of 15
No
No
Drer\hspd1
1 of 15
No
No
Drer\mkks
1 of 15
No
Yes
Drer\tcp1
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (8)
Cele\cct-6
12 of 15
Yes
Yes
Cele\cct-3
2 of 15
No
No
Cele\cct-1
1 of 15
No
No
Cele\cct-2
1 of 15
No
No
Cele\cct-4
1 of 15
No
No
Cele\cct-5
1 of 15
No
No
Cele\cct-7
1 of 15
No
No
Cele\cct-8
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (2)
Atha\AT3G02530
9 of 9
Yes
Yes
Atha\AT5G16070
9 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (9)
Scer\CCT6
13 of 15
Yes
Yes
Scer\CCT2
1 of 15
No
No
Scer\CCT3
1 of 15
No
No
Scer\CCT4
1 of 15
No
No
Scer\CCT5
1 of 15
No
No
Scer\CCT7
1 of 15
No
No
Scer\HSP60
1 of 15
No
No
Scer\TCM62
1 of 15
No
No
Scer\TCP1
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\cct6
11 of 12
Yes
Yes
Other Organism Orthologs (via OrthoDB)
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (12)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
CCT3
4 of 10
CCT4
4 of 10
CCT5
4 of 10
CCT1
3 of 10
CCT2
3 of 10
CCT7
3 of 10
CCT8
3 of 10
Hsp60A
2 of 10
Hsp60B
2 of 10
Hsp60C
2 of 10
Hsp60D
2 of 10
fab1
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 3 )
Potential Models Based on Orthology ( 0 )
Human Ortholog
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Allele
Disease
Interaction
References
Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
CCT6A; chaperonin containing TCP1 subunit 6A
13 of 15
104613
      CCT6B; chaperonin containing TCP1 subunit 6B
      12 of 15
      610730
          Functional Complementation Data
          Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
          Interactions
          Summary of Physical Interactions
          esyN Network Diagram
          Show neighbor-neighbor interactions:
          Select Layout:
          Legend:
          Protein
          RNA
          Selected Interactor(s)
          Interactions Browser
          View in Interactions Browser
          Please see the Physical Interaction reports below for full details
          protein-protein
          Physical Interaction
          Assay
          References
          CCT6 - ATPsynγ
          experimental knowledge based
          (Guruharsha et al., 2011)
          CCT6 - Akt
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          CCT6 - Arf79F
          experimental knowledge based
          (Guruharsha et al., 2011)
          CCT6 - Arl8
          experimental knowledge based
          (Guruharsha et al., 2011)
          CCT6 - AsnRS
          experimental knowledge based
          (Guruharsha et al., 2011)
          CCT6 - CCT1
          experimental knowledge based
          (Guruharsha et al., 2011)
          CCT6 - CCT2
          experimental knowledge based
          (Guruharsha et al., 2011)
          CCT6 - CCT3
          experimental knowledge based
          (Guruharsha et al., 2011)
          CCT6 - CCT4
          experimental knowledge based
          (Guruharsha et al., 2011)
          CCT6 - CCT5
          experimental knowledge based
          (Guruharsha et al., 2011)
          CCT6 - CCT7
          experimental knowledge based
          (Guruharsha et al., 2011)
          CCT6 - CCT8
          experimental knowledge based
          (Guruharsha et al., 2011)
          CCT6 - CG1416
          experimental knowledge based
          (Guruharsha et al., 2011)
          CCT6 - CG33303
          experimental knowledge based
          (Guruharsha et al., 2011)
          CCT6 - CG5854
          experimental knowledge based
          (Guruharsha et al., 2011)
          CCT6 - Chc
          experimental knowledge based
          (Guruharsha et al., 2011)
          CCT6 - Cnx99A
          experimental knowledge based
          (Guruharsha et al., 2011)
          CCT6 - Cyp12d1-p
          experimental knowledge based
          (Guruharsha et al., 2011)
          CCT6 - Dredd
          anti tag coimmunoprecipitation, peptide massfingerprinting
          (Fukuyama et al., 2012)
          CCT6 - Droj2
          experimental knowledge based
          (Guruharsha et al., 2011)
          CCT6 - FASN1
          experimental knowledge based
          (Guruharsha et al., 2011)
          CCT6 - GCS2β
          experimental knowledge based
          (Guruharsha et al., 2011)
          CCT6 - Gale
          experimental knowledge based
          (Guruharsha et al., 2011)
          CCT6 - Gfat2
          experimental knowledge based
          (Guruharsha et al., 2011)
          CCT6 - GluProRS
          experimental knowledge based
          (Guruharsha et al., 2011)
          CCT6 - Gp93
          experimental knowledge based
          (Guruharsha et al., 2011)
          CCT6 - Hel25E
          experimental knowledge based
          (Guruharsha et al., 2011)
          CCT6 - Idh3a
          experimental knowledge based
          (Guruharsha et al., 2011)
          CCT6 - Ipo9
          experimental knowledge based
          (Guruharsha et al., 2011)
          CCT6 - Kap-α3
          experimental knowledge based
          (Guruharsha et al., 2011)
          CCT6 - Kr-h2
          experimental knowledge based
          (Guruharsha et al., 2011)
          CCT6 - Ldh
          experimental knowledge based
          (Guruharsha et al., 2011)
          CCT6 - Lst8
          anti tag coimmunoprecipitation, peptide massfingerprinting
          (Glatter et al., 2011)
          CCT6 - MRP
          experimental knowledge based
          (Guruharsha et al., 2011)
          CCT6 - Mcad
          experimental knowledge based
          (Guruharsha et al., 2011)
          CCT6 - Mec2
          experimental knowledge based
          (Guruharsha et al., 2011)
          CCT6 - Mer
          anti tag coimmunoprecipitation, peptide massfingerprinting
          (Kwon et al., 2013)
          CCT6 - Mpcp2
          experimental knowledge based
          (Guruharsha et al., 2011)
          CCT6 - Nfs1
          experimental knowledge based
          (Guruharsha et al., 2011)
          CCT6 - Ost48
          experimental knowledge based
          (Guruharsha et al., 2011)
          CCT6 - OstΔ
          experimental knowledge based
          (Guruharsha et al., 2011)
          CCT6 - PCB
          experimental knowledge based
          (Guruharsha et al., 2011)
          CCT6 - Past1
          experimental knowledge based
          (Guruharsha et al., 2011)
          CCT6 - Pdk1
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          CCT6 - Pp2A-29B
          experimental knowledge based
          (Guruharsha et al., 2011)
          CCT6 - Psa
          experimental knowledge based
          (Guruharsha et al., 2011)
          CCT6 - Rab2
          experimental knowledge based
          (Guruharsha et al., 2011)
          CCT6 - Rab5
          experimental knowledge based
          (Guruharsha et al., 2011)
          CCT6 - Rab7
          experimental knowledge based
          (Guruharsha et al., 2011)
          CCT6 - Rap2l
          experimental knowledge based
          (Guruharsha et al., 2011)
          CCT6 - Rdh1
          experimental knowledge based
          (Guruharsha et al., 2011)
          CCT6 - RpS10b
          experimental knowledge based
          (Guruharsha et al., 2011)
          CCT6 - Rpt1
          experimental knowledge based
          (Guruharsha et al., 2011)
          CCT6 - Rpt2
          experimental knowledge based
          (Guruharsha et al., 2011)
          CCT6 - Rpt4
          experimental knowledge based
          (Guruharsha et al., 2011)
          CCT6 - Rpt5
          experimental knowledge based
          (Guruharsha et al., 2011)
          CCT6 - Rpt6
          experimental knowledge based
          (Guruharsha et al., 2011)
          CCT6 - SERCA
          experimental knowledge based
          (Guruharsha et al., 2011)
          CCT6 - ScsβA
          experimental knowledge based
          (Guruharsha et al., 2011)
          CCT6 - ScsβG
          experimental knowledge based
          (Guruharsha et al., 2011)
          CCT6 - SerRS
          experimental knowledge based
          (Guruharsha et al., 2011)
          CCT6 - Tapδ
          experimental knowledge based
          (Guruharsha et al., 2011)
          CCT6 - Tspo
          experimental knowledge based
          (Guruharsha et al., 2011)
          CCT6 - UQCR-C2
          experimental knowledge based
          (Guruharsha et al., 2011)
          CCT6 - Vha68-2
          experimental knowledge based
          (Guruharsha et al., 2011)
          CCT6 - cathD
          experimental knowledge based
          (Guruharsha et al., 2011)
          CCT6 - foxo
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          CCT6 - mEFTu1
          experimental knowledge based
          (Guruharsha et al., 2011)
          CCT6 - mst
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Palumbo et al., 2015)
          CCT6 - shd
          experimental knowledge based
          (Guruharsha et al., 2011)
          CCT6 - sima
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          CCT6 - spidey
          experimental knowledge based
          (Guruharsha et al., 2011)
          CCT6 - wal
          experimental knowledge based
          (Guruharsha et al., 2011)
          CCT6 - wts
          anti tag coimmunoprecipitation, peptide massfingerprinting
          (Kwon et al., 2013)
          Summary of Genetic Interactions
          esyN Network Diagram
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          External Data
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          DroID - A comprehensive database of gene and protein interactions.
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Pathways
          Signaling Pathways (FlyBase)
          Metabolic Pathways
          FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
          External Data
          Linkouts
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          Genomic Location and Detailed Mapping Data
          Chromosome (arm)
          X
          Recombination map
          1-51
          Cytogenetic map
          13E13-13E14
          Sequence location
          FlyBase Computed Cytological Location
          Cytogenetic map
          Evidence for location
          13E13-13E14
          Limits computationally determined from genome sequence between P{EP}EP1489 and P{EP}BEST:RE35685EP1581&P{EP}sdEP1088
          Experimentally Determined Cytological Location
          Cytogenetic map
          Notes
          References
          13F1-13F2
          (determined by in situ hybridisation) 13E7--15 (determined by in situ hybridisation)
          (Peter et al., 2002)
          13F1-13F2
          (determined by in situ hybridisation) 13E8--15 (determined by in situ hybridisation) 13E7--15 (determined by in situ hybridisation)
          (Schäfer et al., 1999.6.15)
          13F1-13F2
          (determined by in situ hybridisation)
          (Schäfer et al., 1999.3.29)
          Experimentally Determined Recombination Data
          Location

          1-51

          (FlyBase, 2016)

          1-51.9

          (Comeron et al., 2012)
          Left of (cM)
          Right of (cM)
          Notes
          Stocks and Reagents
          Stocks (6)
          Genomic Clones (11)
           

          Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

          cDNA Clones (123)
           

          Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

          cDNA clones, fully sequenced
          BDGP DGC clones
          Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
          Other clones
          RNAi and Array Information
          Linkouts
          DRSC - Results frm RNAi screens
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          Antibody Information
          Laboratory Generated Antibodies
           
          Commercially Available Antibodies
           
          Other Information
          Relationship to Other Genes
          Source for database identify of

          Source for identity of: Tcp-1ζ l(1)G0022

          (Goshima et al., 2007)

          Source for identity of: CCT6 Tcp-1ζ

          (Monzo et al., 2010)
          Source for database merge of

          Source for merge of: l(1)G0022 CG8231 l(1)G0027 l(1)G0057

          (Peter et al., 2002)
          Additional comments

          FlyBase curator comment: Renamed from 'Tcp-1ζ' to 'CCT6' to unify the nomenclature used for the CCT/TRiC subunits in FlyBase, following the nomenclature used in this paper (FBrf0210519) and other species.

          (Monzo et al., 2010)
          Other Comments

          Tcp-1ζ is involved in centriole duplication and is required for efficient recruitment of pericentriolar material.

          (Dobbelaere et al., 2008)

          RNAi screen using dsRNA made from templates generated with primers directed against this gene in S2 cell results in dim staining of microtubules, and a short monopolar spindle. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA.

          (Goshima et al., 2007)
          Origin and Etymology
          Discoverer
          Etymology
          Identification
          External Crossreferences and Linkouts ( 43 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
          Other crossreferences
          AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
          DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
          EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          Flygut - An atlas of the Drosophila adult midgut
          FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          InterPro - A database of protein families, domains and functional sites
          KEGG Genes - Molecular building blocks of life in the genomic space.
          MARRVEL_MODEL - MARRVEL (model organism gene)
          modMine - A data warehouse for the modENCODE project
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          DroID - A comprehensive database of gene and protein interactions.
          DRSC - Results frm RNAi screens
          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
          FlyMine - An integrated database for Drosophila genomics
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          Synonyms and Secondary IDs (23)
          Datasets (8)
          Study focus (0)
          Experimental Role
          Project
          Project Type
          Title
          Study result (8)
          Result
          Result Type
          Title
          scRNAseq_2020_Cattenoz_NI_seq_clustering
          Clustering analysis of hemocytes from non-infested third instar larvae
          scRNAseq_2020_Cattenoz_WI_seq_clustering
          Clustering analysis of hemocytes from wasp-infested third instar larvae
          scRNAseq_2020_Cho_NI72LG_seq_clustering
          Clustering analysis of lymph gland cells from non-infested larvae at 72 h after egg-laying
          scRNAseq_2020_Cho_NI96LG_seq_clustering
          Clustering analysis of lymph gland cells from non-infested larvae at 96 h after egg-laying
          scRNAseq_2020_Cho_NI120LG_seq_clustering
          Clustering analysis of lymph gland cells from non-infested larvae at 120 h after egg-laying
          scRNAseq_2020_Cho_WI96LG_seq_clustering
          Clustering analysis of lymph gland cells from wasp-infested larvae at 96 h after egg-laying
          scRNAseq_2020_Cho_NI96HL_seq_clustering
          Clustering analysis of circulating hemocytes from non-infested larvae at 96 h after egg-laying
          scRNAseq_2020_Cho_NI120HL_seq_clustering
          Clustering analysis of circulating hemocytes from non-infested larvae at 120 h after egg-laying
          References (70)