FB2020_06, released Dec 22, 2020

Gene: Dmel\Kap-α3

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General Information
Symbol
Dmel\Kap-α3
Species
D. melanogaster
Name
karyopherin α3
Annotation Symbol
CG9423
Feature Type
protein_coding_gene
FlyBase ID
FBgn0027338
Gene Model Status
Current
Stock Availability
9 publicly available
Gene Snapshot
karyopherin α3 (Kap-α3) encodes a protein required for the nuclear import of the product of N. [Date last reviewed: 2019-09-12]
Other Summaries
Also Known As

imp-α3, importin α3, Importin-α3, impα3, karyopherin a3

Key Links
Genomic Location
Cytogenetic map
85D25-85D25
Sequence location
3R:9,574,484..9,577,733 [-]
Recombination map

3-48

RefSeq locus
NT_033777 REGION:9574484..9577733
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (10 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
enables myosin binding
inferred from physical interaction with FLYBASE:Myo10A; FB:FBgn0263705
(Liu et al., 2008)
enables Notch binding
inferred from direct assay
(Sachan et al., 2013)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables nuclear import signal receptor activity
inferred from biological aspect of ancestor with PANTHER:PTN000593662
(assigned by GO_Central )
(Gaudet et al., 2011)
enables nuclear localization sequence binding
inferred from biological aspect of ancestor with PANTHER:PTN000593662
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
involved_in protein import into nucleus
inferred from mutant phenotype
(Sachan et al., 2013)
involved_in response to UV
inferred from direct assay
(Ting et al., 2007)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in NLS-bearing protein import into nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000593662
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
located_in cytoplasm
inferred from electronic annotation with InterPro:IPR024931, InterPro:IPR036975
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
located_in nucleoplasm
inferred from biological aspect of ancestor with PANTHER:PTN001153232
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000593662
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
ALPHA IMPORTINS -
The importin-α proteins mediate nuclear import by acting as adaptors that link classical nuclear localization signal containing proteins to importin-β. (Adapted from FBrf0149010, FBrf0207686 and PMID:15350979).
Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Kap-α3 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.47

Low-frequency RNA-Seq exon junction(s) not annotated.

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Kap-α3-RA
FBtr0082106
NM_169295
2280
514
Kap-α3-RB
FBtr0082107
NM_169296
2728
514
Kap-α3-RC
FBtr0082108
NM_176437
2663
514
Kap-α3-RD
FBtr0301189
NM_001170101
2261
514
Additional Transcript Data and Comments
Reported size (kB)

2.2 (unknown)

(Mathe et al., 2000)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Kap-α3-PA
FBpp0081584
57.0
514
4.91
NP_731377
AAF54408
Kap-α3-PB
FBpp0081585
57.0
514
4.91
NP_731378
AAN13435
Kap-α3-PC
FBpp0081586
57.0
514
4.91
NP_788614
AAO41526
Kap-α3-PD
FBpp0290407
57.0
514
4.91
NP_001163572
ACZ94869
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

514 aa isoforms: Kap-α3-PA, Kap-α3-PB, Kap-α3-PC, Kap-α3-PD
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Kap-α3 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 12
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
embryonic/larval midgut
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
ventral nerve cord
(Fisher et al., 2012)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage -- adult stage
(Mathe et al., 2000)
Additional Descriptive Data

karyopherin-α3 transcripts are detected throughout development. They are most abundant in embryos and in adult females.

(Mathe et al., 2000)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
eye photoreceptor cell | restricted
(Ting et al., 2007)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Kap-α3 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 9 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 12 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Kap-α3
Transgenic constructs containing regulatory region of Kap-α3
Deletions and Duplications ( 5 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL4pnr-MD237
lethal (with Kap-α3D93)
lethal (with Kap-α3D165)
lethal | heat sensitive, with Scer\GAL4e22c
lethal - all die before end of larval stage
lethal - all die before end of larval stage, with Scer\GAL4da.G32
lethal - all die before end of larval stage (with Df(3R)by416)
lethal - all die before end of larval stage (with Df(3R)GB104)
lethal - all die before end of larval stage (with Kap-α317-7)
lethal - all die before end of larval stage (with Kap-α3D93)
lethal - all die before end of larval stage (with Kap-α3D165)
lethal - all die before end of larval stage (with Kap-α3w73)
lethal - all die during P-stage, with Scer\GAL4Mef2.PR
partially lethal - majority die, with Scer\GAL4pnr-MD237
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
fertile
fertile | female (with Kap-α3D93)
fertile | female (with Kap-α3D165)
Other Phenotypes
Allele
neuroanatomy defective
phototaxis defective | somatic clone
some die during larval stage
some die during larval stage, with Scer\GAL4da.G32
some die during larval stage (with Df(3R)by416)
some die during larval stage (with Df(3R)GB104)
some die during larval stage (with Kap-α317-7)
some die during larval stage (with Kap-α3D93)
some die during larval stage (with Kap-α3D165)
some die during larval stage (with Kap-α3w73)
visible, with Scer\GAL4pnr-MD237
visible | somatic clone
wild-type
Phenotype manifest in
Allele
eye | somatic clone
eye disc | somatic clone | third instar larval stage
interommatidial bristle | somatic clone
mesothoracic tergum, with Scer\GAL4pnr-MD237
ommatidium | somatic clone
photoreceptor cell R7
photoreceptor cell R7 | somatic clone
rhabdomere | somatic clone
salivary gland | somatic clone | third instar larval stage
tergite, with Scer\GAL4e22c
tormogen cell, with Scer\GAL4pnr-MD237
tormogen cell | somatic clone
wing disc | third instar larval stage, with Scer\GAL4en.PU
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (8)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\KPNA4
14 of 15
Yes
Yes
Hsap\KPNA3
12 of 15
No
Yes
Hsap\KPNA1
5 of 15
No
No
Hsap\KPNA5
5 of 15
No
No
Hsap\KPNA6
5 of 15
No
No
Hsap\KPNA2
3 of 15
No
No
Hsap\KPNA7
3 of 15
No
No
Hsap\SPAG6
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (9)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Kpna4
13 of 15
Yes
Yes
Mmus\Kpna3
12 of 15
No
Yes
Mmus\Kpna1
5 of 15
No
No
Mmus\Kpna6
5 of 15
No
No
Mmus\Kpna7
3 of 15
No
No
Mmus\Kpna2
2 of 15
No
No
Mmus\Gm10184
1 of 15
No
No
Mmus\Spag6l
1 of 15
No
Yes
Mmus\Spag6
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (10)
Rnor\Kpna4
12 of 13
Yes
Yes
Rnor\Kpna3
9 of 13
No
Yes
Rnor\Kpna5
4 of 13
No
No
Rnor\Kpna2
3 of 13
No
No
Rnor\Kpna6
3 of 13
No
No
Rnor\Kpna7
3 of 13
No
No
Rnor\Kpna1
2 of 13
No
No
Rnor\LOC100359600
1 of 13
No
No
Rnor\Spag6l
1 of 13
No
Yes
Rnor\Spag6
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (8)
Xtro\kpna4
8 of 12
Yes
Yes
Xtro\kpna3
7 of 12
No
Yes
Xtro\kpna1
3 of 12
No
No
Xtro\kpna2
3 of 12
No
No
Xtro\kpna6
3 of 12
No
No
Xtro\kpna7
3 of 12
No
No
Xtro\armc3
1 of 12
No
No
Xtro\spag6
1 of 12
No
Yes
Danio rerio (Zebrafish) (8)
Drer\kpna3
12 of 15
Yes
Yes
Drer\kpna4
8 of 15
No
Yes
Drer\kpna5
5 of 15
No
No
Drer\kpna6
5 of 15
No
No
Drer\kpna1
4 of 15
No
No
Drer\kpna7
3 of 15
No
No
Drer\kpna2
2 of 15
No
No
Drer\spag6
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (4)
Cele\ima-3
13 of 15
Yes
Yes
Cele\ima-2
2 of 15
No
No
Cele\F53B2.5
1 of 15
No
No
Cele\ima-1
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (11)
Atha\IMPA-1
5 of 9
Yes
No
Atha\IMPA-2
5 of 9
Yes
No
Atha\IMPA-4
5 of 9
Yes
No
Atha\IMPA-6
5 of 9
Yes
No
Atha\MOS6
5 of 9
Yes
No
Atha\IMPA-5
4 of 9
No
No
Atha\IMPA-7
3 of 9
No
No
Atha\AT1G32880
2 of 9
No
Yes
Atha\AT5G49305
2 of 9
No
Yes
Atha\IMPA-8
2 of 9
No
No
Atha\IMPA-9
1 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\SRP1
8 of 15
Yes
No
Schizosaccharomyces pombe (Fission yeast) (2)
Spom\cut15
5 of 12
Yes
No
Spom\imp1
5 of 12
Yes
No
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091905WM )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00009614
Drosophila simulans
Dsim\GD20781
Drosophila sechellia
Dsec\GM26241
Drosophila erecta
Dere\GG17355
Drosophila yakuba
Dyak\GE24760
Drosophila ananassae
Dana\GF16531
Drosophila pseudoobscura pseudoobscura
Dpse\GA21775
Drosophila persimilis
Dper\GL21493
Drosophila willistoni
Dwil\GK14517
Drosophila virilis
Dvir\GJ10266
Drosophila mojavensis
Dmoj\GI23514
Drosophila grimshawi
Dgri\GH19298
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091503JB )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17016192
Glossina morsitans
Tsetse fly
Gmor\GMOY009034
Mayetiola destructor
Hessian fly
Mdes\Mdes007588
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL011657
Anopheles darlingi
American malaria mosquito
Adar\ADAC008695
Anopheles gambiae
Malaria mosquito
Agam\AGAP001273
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ001179
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W04WH )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA012556
Bombyx mori
Silkmoth
Bmor\BGIBMGA003758
Danaus plexippus
Monarch butterfly
Dple\DPOGS210133-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL011605
Apis florea
Little honeybee
Aflo\2760967236
Apis florea
Little honeybee
Aflo\3219164820
Apis florea
Little honeybee
Aflo\3312488340
Apis mellifera
Western honey bee
Amel\Kap-alpha1
Apis mellifera
Western honey bee
Amel\GB40656
Apis mellifera
Western honey bee
Amel\Kap-alpha3
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP24976
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP12538
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP10382
Bombus terrestris
Buff-tailed bumblebee
Bter\15216159
Bombus terrestris
Buff-tailed bumblebee
Bter\15206037
Bombus terrestris
Buff-tailed bumblebee
Bter\15207447
Linepithema humile
Argentine ant
Lhum\LH24866
Linepithema humile
Argentine ant
Lhum\LH24780
Linepithema humile
Argentine ant
Lhum\LH14911
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001019
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001b17
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0011ed
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG009939
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG011647
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG019902
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_02952
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_01500
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_10340
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_01907
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_00244
Tribolium castaneum
Red flour beetle
Tcas\TC000963
Tribolium castaneum
Red flour beetle
Tcas\TC000505
Tribolium castaneum
Red flour beetle
Tcas\TC014465
Pediculus humanus
Human body louse
Phum\PHUM567490
Pediculus humanus
Human body louse
Phum\PHUM584050
Pediculus humanus
Human body louse
Phum\PHUM221360
Rhodnius prolixus
Kissing bug
Rpro\RPRC013783
Rhodnius prolixus
Kissing bug
Rpro\RPRC011174
Rhodnius prolixus
Kissing bug
Rpro\RPRC011195
Cimex lectularius
Bed bug
Clec\CLEC008022
Cimex lectularius
Bed bug
Clec\CLEC004212
Cimex lectularius
Bed bug
Clec\CLEC005161
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI004245
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI083997
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI005899
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_07274
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_08531
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_01011
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X03XA )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR015473
Strigamia maritima
European centipede
Smar\SMAR005162
Ixodes scapularis
Black-legged tick
Isca\ISCW015584
Ixodes scapularis
Black-legged tick
Isca\ISCW001231
Stegodyphus mimosarum
African social velvet spider
Smim\KFM56800.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM56942.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM76616.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur01g03080
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_309369
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_301478
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_308902
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_233619
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_120132
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_251789
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_301494
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_41349
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G095Z )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Kpna3
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Imp_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Kpna2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Imp_2
Ciona intestinalis
Vase tunicate
Cint\LOC100184003
Ciona intestinalis
Vase tunicate
Cint\LOC100185571
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000008979
Gallus gallus
Domestic chicken
Ggal\KPNA3
Gallus gallus
Domestic chicken
Ggal\KPNA7
Gallus gallus
Domestic chicken
Ggal\KPNA5
Gallus gallus
Domestic chicken
Ggal\KPNA4
Gallus gallus
Domestic chicken
Ggal\KPNA6
Gallus gallus
Domestic chicken
Ggal\KPNA1
Gallus gallus
Domestic chicken
Ggal\KPNA2
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (3)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Kap-α1
7 of 10
Pen
5 of 10
αKap4
3 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 3 )
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    KPNA4; karyopherin subunit alpha 4
    14 of 15
    602970
        KPNA3; karyopherin subunit alpha 3
        12 of 15
        601892
            KPNA1; karyopherin subunit alpha 1
            5 of 15
            600686
                KPNA5; karyopherin subunit alpha 5
                5 of 15
                604545
                    KPNA6; karyopherin subunit alpha 6
                    5 of 15
                    610563
                        KPNA2; karyopherin subunit alpha 2
                        3 of 15
                        600685
                            KPNA7; karyopherin subunit alpha 7
                            3 of 15
                            614107
                                Functional Complementation Data
                                Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                                Interactions
                                Summary of Physical Interactions
                                esyN Network Diagram
                                Show neighbor-neighbor interactions:
                                Select Layout:
                                Legend:
                                Protein
                                RNA
                                Selected Interactor(s)
                                Interactions Browser
                                View in Interactions Browser
                                Please see the Physical Interaction reports below for full details
                                protein-protein
                                Physical Interaction
                                Assay
                                References
                                Kap-α3 - Akt1
                                anti tag coimmunoprecipitation, Identification by mass spectrometry
                                (Vinayagam et al., 2016)
                                Kap-α3 - Atpα
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Kap-α3 - CCT2
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Kap-α3 - CCT3
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Kap-α3 - CCT6
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Kap-α3 - CCT7
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Kap-α3 - CCT8
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Kap-α3 - CG10425
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Kap-α3 - CG1416
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Kap-α3 - CG2064
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Kap-α3 - CG33303
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Kap-α3 - Chc
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Kap-α3 - Cnx99A
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Kap-α3 - Cyp12d1-p
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Kap-α3 - Dis3
                                anti tag coimmunoprecipitation, western blot, Identification by mass spectrometry
                                (Mamolen et al., 2010, Graham et al., 2009)
                                Kap-α3 - Fatp1
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Kap-α3 - Fs(2)Ket
                                pull down, western blot
                                (Mathe et al., 2000)
                                Kap-α3 - GCS2β
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Kap-α3 - Gale
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Kap-α3 - GluProRS
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Kap-α3 - Gp93
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Kap-α3 - Idh3a
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Kap-α3 - Karyβ3
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Kap-α3 - Kr-h2
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Kap-α3 - MRP
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Kap-α3 - Mcad
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Kap-α3 - Mec2
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Kap-α3 - Mpcp2
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Kap-α3 - Myo10A
                                two hybrid, pull down, autoradiography
                                (Liu et al., 2008)
                                Kap-α3 - N
                                pull down, western blot, two hybrid, anti tag coimmunoprecipitation
                                (Sachan et al., 2013)
                                Kap-α3 - Nfs1
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Kap-α3 - Ost48
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Kap-α3 - OstΔ
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Kap-α3 - Past1
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Kap-α3 - Pen
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Kap-α3 - PolA1
                                two hybrid
                                (Mathe et al., 2000)
                                Kap-α3 - Pp2A-29B
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Kap-α3 - Ranbp9
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Kap-α3 - S6k
                                anti tag coimmunoprecipitation, Identification by mass spectrometry
                                (Vinayagam et al., 2016)
                                Kap-α3 - S6kII
                                anti tag coimmunoprecipitation, Identification by mass spectrometry
                                (Vinayagam et al., 2016)
                                Kap-α3 - Sc2
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Kap-α3 - ScsβG
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Kap-α3 - Sec61α
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Kap-α3 - SerRS
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Kap-α3 - Smox
                                anti tag coimmunoprecipitation, anti tag western blot, western blot
                                (Ting et al., 2007)
                                Kap-α3 - UQCR-C2
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Kap-α3 - Vps4
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Kap-α3 - ci
                                anti tag coimmunoprecipitation, anti tag western blot, two hybrid
                                (Seong et al., 2010)
                                Kap-α3 - cid
                                anti tag coimmunoprecipitation, peptide massfingerprinting
                                (Boltengagen et al., 2016)
                                Kap-α3 - mEFTu1
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Kap-α3 - nkd
                                two hybrid, pull down, autoradiography
                                (Chan et al., 2008)
                                Kap-α3 - piwi
                                anti bait coimmunoprecipitation, anti tag western blot
                                (Yashiro et al., 2018)
                                Kap-α3 - rictor
                                anti tag coimmunoprecipitation, Identification by mass spectrometry
                                (Vinayagam et al., 2016)
                                Kap-α3 - sd
                                anti tag coimmunoprecipitation, western blot
                                (Magico and Bell, 2011)
                                Kap-α3 - sima
                                anti tag coimmunoprecipitation, Identification by mass spectrometry
                                (Vinayagam et al., 2016)
                                Kap-α3 - spidey
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Kap-α3 - wal
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Kap-α3 - βCOP
                                experimental knowledge based
                                (Guruharsha et al., 2011)
                                Summary of Genetic Interactions
                                esyN Network Diagram
                                esyN Network Key:
                                Suppression
                                Enhancement
                                View in Interactions Browser
                                Please look at the allele data for full details of the genetic interactions
                                Starting gene(s)
                                Interaction type
                                Interacting gene(s)
                                Reference
                                Kap-α3
                                suppressible
                                Kap-α1
                                (Mason et al., 2003)
                                Kap-α3
                                suppressible
                                Pen
                                (Mason et al., 2003)
                                Kap-α3
                                enhanceable
                                sev
                                (Ting et al., 2007)
                                Kap-α3
                                enhanceable
                                tutl
                                (Ferguson et al., 2009)
                                Starting gene(s)
                                Interaction type
                                Interacting gene(s)
                                Reference
                                Dl
                                enhanceable
                                Kap-α3
                                (Sachan et al., 2013)
                                dx
                                enhanceable
                                Kap-α3
                                (Sachan et al., 2013)
                                l(3)S033513
                                suppressible
                                Kap-α3
                                (Mathe et al., 2000)
                                N
                                enhanceable
                                Kap-α3
                                (Sachan et al., 2013)
                                N
                                suppressible
                                Kap-α3
                                (Sachan et al., 2013)
                                Pen
                                suppressible
                                Kap-α3
                                (Mason et al., 2002)
                                Ser
                                enhanceable
                                Kap-α3
                                (Sachan et al., 2013)
                                tutl
                                enhanceable
                                Kap-α3
                                (Ferguson et al., 2009)
                                External Data
                                Linkouts
                                BioGRID - A database of protein and genetic interactions.
                                DroID - A comprehensive database of gene and protein interactions.
                                InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                                MIST (genetic) - An integrated Molecular Interaction Database
                                MIST (protein-protein) - An integrated Molecular Interaction Database
                                Pathways
                                Signaling Pathways (FlyBase)
                                Metabolic Pathways
                                External Data
                                Linkouts
                                Genomic Location and Detailed Mapping Data
                                Chromosome (arm)
                                3R
                                Recombination map

                                3-48

                                Cytogenetic map
                                85D25-85D25
                                Sequence location
                                3R:9,574,484..9,577,733 [-]
                                FlyBase Computed Cytological Location
                                Cytogenetic map
                                Evidence for location
                                85D25-85D25
                                Limits computationally determined from genome sequence between P{EP}CG9393EP3122 and P{EP}CrcEP3006
                                Experimentally Determined Cytological Location
                                Cytogenetic map
                                Notes
                                References
                                85E10-85E13
                                (Mathe, 2000.2.2)
                                85E10-85E15
                                (Mathe, 2000.2.2, Mathe, 2000.2.2)
                                85A-85F
                                (Mason, 1998.6.29)
                                85D18-85D27
                                (Dockendorff, 1999.5.19)
                                85E1-85E7
                                (determined by in situ hybridisation)
                                (Szeged Stock Center, 1998-, Deak et al., 1997)
                                Experimentally Determined Recombination Data
                                Location

                                3-48

                                (FlyBase, 2016)

                                3-46.2

                                (Comeron et al., 2012)
                                Left of (cM)
                                Right of (cM)
                                Notes
                                Stocks and Reagents
                                Stocks (9)
                                Genomic Clones (15)
                                 

                                Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                                cDNA Clones (221)
                                 

                                Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                                cDNA clones, fully sequenced
                                BDGP DGC clones
                                Other clones
                                Drosophila Genomics Resource Center cDNA clones

                                For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                                cDNA Clones, End Sequenced (ESTs)
                                BDGP DGC clones
                                Other clones
                                RNAi and Array Information
                                Linkouts
                                DRSC - Results frm RNAi screens
                                GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                                Antibody Information
                                Laboratory Generated Antibodies
                                 

                                monoclonal

                                (Yashiro et al., 2018)

                                polyclonal

                                (Mathe et al., 2000)
                                Commercially Available Antibodies
                                 
                                Other Information
                                Relationship to Other Genes
                                Source for database identify of
                                Source for database merge of

                                Source for merge of: karyopherin-α3 l(3)S033513

                                (Mathe et al., 2000)

                                Source for merge of: karyopherin-α3 karyopherin-α4

                                (FlyBase, 1996-)

                                Source for merge of: karyopherin α3 imp-a3

                                (FlyBase, 1996-)
                                Additional comments

                                Source for merge of karyopherin-α3 karyopherin-α4 was sequence comparison ( date:000103 ).

                                (FlyBase, 1996-)

                                Source for merge of karyopherin α3 imp-a3 was sequence comparison ( date:991222 ).

                                (FlyBase, 1996-)
                                Other Comments

                                Kap-α3 is required in R7 neurons to mediate a normal preference for UV light.

                                (Ting et al., 2007)

                                RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.

                                (Boutros et al., 2004)

                                Area matching Drosophila Karyophilin alpha 3 gene, Acc. No. AF152928.

                                (Davies, 2001.3.15)

                                Kap-α3 protein binds specifically to the nuclear localisation sequence of Hsf protein.

                                (Fang et al., 2001)
                                Origin and Etymology
                                Discoverer
                                Etymology
                                Identification
                                External Crossreferences and Linkouts ( 70 )
                                Sequence Crossreferences
                                NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                                GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                                Other crossreferences
                                BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                                Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                                Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                                Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                                Flygut - An atlas of the Drosophila adult midgut
                                GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                                iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                                InterPro - A database of protein families, domains and functional sites
                                KEGG Genes - Molecular building blocks of life in the genomic space.
                                modMine - A data warehouse for the modENCODE project
                                SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                                Linkouts
                                BioGRID - A database of protein and genetic interactions.
                                DroID - A comprehensive database of gene and protein interactions.
                                DRSC - Results frm RNAi screens
                                FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                                FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                                FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                                FlyMine - An integrated database for Drosophila genomics
                                InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                                MIST (genetic) - An integrated Molecular Interaction Database
                                MIST (protein-protein) - An integrated Molecular Interaction Database
                                Synonyms and Secondary IDs (41)
                                Reported As
                                Symbol Synonym
                                0335/13
                                (Deak et al., 1997)
                                CG9423
                                (Kolkhof et al., 2017, Boltengagen et al., 2016, Çiçek et al., 2016, Hosono et al., 2015, Rosa-Ferreira et al., 2015, Shanshan and Laixin, 2015, Bonnay et al., 2014, Chen et al., 2012, Zhang et al., 2010, Keleman et al., 2009.8.5, Mason and Goldfarb, 2009, Mason et al., 2009, Perkins et al., 2009, Liu et al., 2008)
                                Dα3
                                (Ratan et al., 2008, Chamaon et al., 2002)
                                IMPα3
                                (Hogarth et al., 2005)
                                Imp α-3
                                (Wong and Baylies, 2004)
                                Imp-α3
                                (Magico and Bell, 2011)
                                Impα3
                                (Yashiro et al., 2018)
                                KAP-ALPHA3
                                (Kondo and Perrimon, 2011)
                                Kap α3
                                (Mason et al., 1999)
                                Kap-?3
                                (Tomancak et al., 2007)
                                Kap-alpha3
                                (Sowa et al., 2018, Boeynaems et al., 2016, Lee et al., 2016, Sarov et al., 2016, Dent et al., 2015, Tsou et al., 2015, Ugrankar et al., 2015, Gonzalez et al., 2014, Kwon et al., 2013, Friedman et al., 2011, Bartkuhn et al., 2009, Giot et al., 2003)
                                Kap-α3
                                (Tokusumi et al., 2012, Chan et al., 2011, Chittaranjan et al., 2009, Mummery-Widmer et al., 2009, Doheny et al., 2008, Gwack et al., 2007)
                                Kapα3
                                (McElroy et al., 2008)
                                Kpn-alpha3
                                (Bonnay et al., 2014)
                                Kpna3
                                (Hogarth et al., 2005)
                                dKap-α3
                                (Fang et al., 2001)
                                dimpα3
                                (Mamolen et al., 2010)
                                imp α3
                                (Sachan et al., 2013, Fleming et al., 2005)
                                imp-a3
                                imp-α3
                                (Kniss et al., 2013, Virágh et al., 2012, Hadjieconomou et al., 2011, Ferguson et al., 2009, Ting et al., 2007, Tekotte et al., 2002, Mathe et al., 2000)
                                impα3
                                (Asaoka et al., 2019, Sachan et al., 2013, Graham et al., 2009, McElroy et al., 2008)
                                kpn-α3
                                (Bonnay et al., 2014)
                                l(3)S033513
                                αKap3
                                (Phadnis et al., 2012)
                                Name Synonyms
                                Importin α-3
                                (Wong and Baylies, 2005)
                                Importin α3
                                (Mason et al., 2009)
                                Importin-α3
                                (Solomon et al., 2018, Sachan et al., 2013, Magico and Bell, 2011, Mosca and Schwarz, 2010, Ting et al., 2007, Mathe et al., 2000)
                                Karyopherin α3
                                (Boltengagen et al., 2016, Mummery-Widmer et al., 2009)
                                dImportin-α3
                                (Mamolen et al., 2010)
                                importin a3
                                importin alpha-3
                                (Cotterill, 1999.4.1)
                                importin α
                                (Silverman-Gavrila and Wilde, 2006)
                                importin α3
                                (Jang et al., 2015, Seong et al., 2010, Mason and Goldfarb, 2009, Sabri et al., 2007, Hogarth et al., 2005, Mason et al., 2003, Mason et al., 2002)
                                importin-α3
                                (Ferguson et al., 2009, Graham et al., 2009, Chan et al., 2008, Chan et al., 2007)
                                karyopherin
                                (Tsou et al., 2015)
                                karyopherin a3
                                (Parker et al., 2003, Parker et al., 1999)
                                karyopherin α3
                                (Mason and Goldfarb, 2009, Liu et al., 2008)
                                karyopherin α4
                                karyopherin-alpha3
                                (Boutros et al., 2004)
                                karyopherin-α3
                                (Sachan et al., 2013, Leatherman and Jongens, 2003)
                                karyopherin-α4
                                Secondary FlyBase IDs
                                • FBgn0024888
                                • FBgn0026235
                                • FBgn0028164
                                Datasets (0)
                                Study focus (0)
                                Experimental Role
                                Project
                                Project Type
                                Title
                                References (115)