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Gene Dmel\Kap-α3

General Information
Symbol	Dmel\Kap-α3	Species	D. melanogaster
Name	karyopherin α3	Annotation symbol	CG9423
Feature type	protein_coding_gene	FlyBase ID	FBgn0027338
Gene Model Status	Current	Stock availability	8 publicly available
Also Known As	imp-α3, Kap-alpha3, IMPα3, Dα3
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	85D25-85D25	Sequence location	3R:5,400,206..5,403,455 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene karyopherin α3 is referred to in FlyBase by the symbol Dmel\Kap-α3 (CG9423, FBgn0027338). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding. There is experimental evidence that it is involved in the biological process: mitotic G2 DNA damage checkpoint; positive regulation of NFAT protein import into nucleus; response to UV. 18 alleles are reported. The phenotypes of these alleles are annotated with: photoreceptor cell R7; mesothoracic tergum; tormogen cell; tergite. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: Armadillo; Armadillo-like helical; Armadillo-type fold; Importin subunit alpha; Importin-alpha, importin-beta-binding domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of high expression. Peak expression observed within 00-12 and 18-24 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1635566_s_at completely aligns to an exonic region of only a subset of 3 of the 4 FlyBase-annotated transcript isoforms of Kap-alpha3. Gene sequence location is 3R:5400206..5403455.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 85D25-85D25   Limits computationally determined from genome sequence between P{EP}CG9393EP3122 and P{EP}CrcEP3006
Experimentally Determined Cytological Location
Cytogenetic map Notes References 85E10-85E13     (Mathe, 2000.2.2) 85E10-85E15     (Mathe, 2000.2.2) 85E10-85E15     (Mathe, 2000.2.2) 85A-85F     (Mason, 1998.6.29) 85D18-85D27     (Dockendorff, 1999.5.19) 85E1-85E7   (determined by in situ hybridisation)   (Szeged Stock Center, 1998-) 85E1-85E7   (determined by in situ hybridisation)   (Deak et al., 1997)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Kap-α3 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.47
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Kap-α3-RA FBtr0082106  NM_169295   2280   514 Kap-α3-RB FBtr0082107  NM_169296   2728   514 Kap-α3-RC FBtr0082108  NM_176437   2663   514 Kap-α3-RD FBtr0301189  NM_001170101   2261   514
Additional Transcript Data & Comments
Reported size (kB)	2.2 (unknown) (Mathe et al., 2000)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Kap-α3-PA   FBpp0081584   57.0   514   4.91     NP_731377   AAF54408 Kap-α3-PB   FBpp0081585   57.0   514   4.91     NP_731378   AAN13435 Kap-α3-PC   FBpp0081586   57.0   514   4.91     NP_788614   AAO41526 Kap-α3-PD   FBpp0290407   57.0   514   4.91     NP_001163572   ACZ94869
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Armadillo (IPR000225) Importin-alpha, importin-beta-binding domain (IPR002652) Armadillo-like helical (IPR011989) Armadillo-type fold (IPR016024) Importin subunit alpha (IPR024931)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201676   AA201993   AA202713   AA246332   AA246550   AA246659   AA246784   AA247013   AA247045   AA247079   AA263518   AA263536   AA264234   AA264728   AA264963   AA390355   AA390567   AA391399   AA391793   AA391848   AA391862   AA392469   AA438758   AA439270   AA439367   AA439431   AA439838   AA439844   AA439863   AA440317   AA440361   AA440538   AA440827   AA441167   AA441610   AA536361   AA536405   AA536459   AA538593   AA538781   AA539492   AA540082   AA540179   AA540532   AA540810   AA540965   AA567048   AA735546   AA735649   AA803000   AA816671   AA821016   AA941976   AA942320   AA942395   AA949569   AA949830   AA949917   AA950266   AA950280   AA950557   AA951556   AA952149   AA952230   AA979217   AA990742   AA990834   AE014297 AAF54408   AE014297 AAN13435   AE014297 AAO41526   AE014297 ACZ94869   AF074958 AAC26056   AF152928 AAD37442   AF230871 AAK14941   AF230872 AAF37855   AF230873 AAF37856   AI062481   AI063507   AI295457   AI456787   AI512647   AI512767   AI513937   AI514721   AI515497   AI515536   AI515832   AI515907   AI517850   AI518427   AI518592   AI518703   AI518733   AI519063   AI519081   AI519972   AI520219   AI520362   AI532330   AI534899   AI542919   AI945153   AJ237997 CAB40789   AW942293   AX094224   AY069430 AAL39575   BF496612   BF502562   BF504113   BG638744   BI161704   BI161705   BI163671   BI163933   BI164135   BI164578   BI164884   BI166117   BI166788   BI167295   BI169581   BI170084   BI173922   BI173966   BI213442   BI213917   BI215391   BI216658   BI228902   BI229285   BI231949   BI234074   BI234338   BI236390   BI237013   BI237158   BI238079   BI243573   BI243801   BI354294   BI354409   BI356070   BI356586   BI358063   BI358453   BI363517   BI363822   BI363978   BI364543   BI364620   BI365385   BI365534   BI366311   BI367688   BI368096   BI372111   BI376168   BI376169   BI376173   BI376180   BI485639   BI485642   BI485651   BI485652   BI487253   BI487258   BI565857   BI577122   BI581146   BI581148   BI585346   BI589472   BI607705   BI616103   BI624145   BI632867   BI633010   BI638030   BI641996   BI641997   BI642006   BP547169   BP556071   BP556072   BZ748903   CK660966   CO155223   CO181801   CO185402   CO265738   CO272074   CO274197   CO284759   CO286692   CO290089   CO302575   CO307521   CO309163   CO310169   CO311631   CO311866   CO323610   CO331939   CO333411   EC058055   EC068210   EC076282   EC083500   EC084320   EC090762   EC194457   EC196354   EC205020   EC212006   EC213374   EC214924   EC216577   EC223284   EC235368   EC241383   EC250093   EC264733   EL884756   EL884757   EL884886   EV585804   EV588201   EV593984   EV594018   GH749513   GH749692   GH749966   GH750590   GH757104   GH775580   GH782803   GH797035   GH808093   GH810836   GH818373   GH828402   GH853680   GH857099   GH864137   GH868641   GH870186   GH885509   GH899581   GH901806   GH903075   GH906939   GH908283   GH918861   GH919895   GH930552   GH940763
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9V455 Q9UB78 O76522
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic brain   (Fisher et al., 2012) embryonic/larval midgut   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Mathe et al., 2000)
Additional Descriptive Data
	karyopherin-α3 transcripts are detected throughout development. They are most abundant in embryos and in adult females. (Mathe et al., 2000)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference third instar larval stage   eye photoreceptor cell | restricted   • axon & axon terminus (Ting et al., 2007)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    87.775 Larval Midgut    14.6 Larval Hindgut    44 Larval Malpighian Tubules    42.8 Larval Fat Body    43.4 Larval Salivary Gland    51 Larval Trachea    23.4 Larval Carcass    37.875 Adult Head    28.5 Adult Eye    18.425 Adult Brain    51.3 Adult Thoracic-Abdominal Ganglion    55.9 Adult Crop    46 Adult Midgut    17.3 Adult Hindgut    24.4 Adult Malpighian Tubules    24 Adult Fat Body    33.8 Adult Salivary Gland    38.9 Adult Heart    16.225 Adult VirginFemale Spermatheca    43.6 Adult InseminatedFemale Spermatheca    41.3 Adult Ovary    82.2 Adult Testis    20 Adult Male Accessory Gland    15.3 Adult Carcass    29.5 Expression Level Scale  None   Low  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    87.775 Larval Midgut    14.6 Larval Hindgut    44 Larval Malpighian Tubules    42.8 Larval Fat Body    43.4 Larval Salivary Gland    51 Larval Trachea    23.4 Larval Carcass    37.875 Adult Head    28.5 Adult Eye    18.425 Adult Brain    51.3 Adult Thoracic-Abdominal Ganglion    55.9 Adult Crop    46 Adult Midgut    17.3 Adult Hindgut    24.4 Adult Malpighian Tubules    24 Adult Fat Body    33.8 Adult Salivary Gland    38.9 Adult Heart    16.225 Adult VirginFemale Spermatheca    43.6 Adult InseminatedFemale Spermatheca    41.3 Adult Ovary    82.2 Adult Testis    20 Adult Male Accessory Gland    15.3 Adult Carcass    29.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    87.775 Larval Midgut    14.6 Larval Hindgut    44 Larval Malpighian Tubules    42.8 Larval Fat Body    43.4 Larval Salivary Gland    51 Larval Trachea    23.4 Larval Carcass    37.875 Adult Head    28.5 Adult Eye    18.425 Adult Brain    51.3 Adult Thoracic-Abdominal Ganglion    55.9 Adult Crop    46 Adult Midgut    17.3 Adult Hindgut    24.4 Adult Malpighian Tubules    24 Adult Fat Body    33.8 Adult Salivary Gland    38.9 Adult Heart    16.225 Adult VirginFemale Spermatheca    43.6 Adult InseminatedFemale Spermatheca    41.3 Adult Ovary    82.2 Adult Testis    20 Adult Male Accessory Gland    15.3 Adult Carcass    29.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    87.775 Larval Midgut    14.6 Larval Hindgut    44 Larval Malpighian Tubules    42.8 Larval Fat Body    43.4 Larval Salivary Gland    51 Larval Trachea    23.4 Larval Carcass    37.875 Adult Head    28.5 Adult Eye    18.425 Adult Brain    51.3 Adult Thoracic-Abdominal Ganglion    55.9 Adult Crop    46 Adult Midgut    17.3 Adult Hindgut    24.4 Adult Malpighian Tubules    24 Adult Fat Body    33.8 Adult Salivary Gland    38.9 Adult Heart    16.225 Adult VirginFemale Spermatheca    43.6 Adult InseminatedFemale Spermatheca    41.3 Adult Ovary    82.2 Adult Testis    20 Adult Male Accessory Gland    15.3 Adult Carcass    29.5 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    87.775 Larval Midgut    14.6 Larval Hindgut    44 Larval Malpighian Tubules    42.8 Larval Fat Body    43.4 Larval Salivary Gland    51 Larval Trachea    23.4 Larval Carcass    37.875 Adult Head    28.5 Adult Eye    18.425 Adult Brain    51.3 Adult Thoracic-Abdominal Ganglion    55.9 Adult Crop    46 Adult Midgut    17.3 Adult Hindgut    24.4 Adult Malpighian Tubules    24 Adult Fat Body    33.8 Adult Salivary Gland    38.9 Adult Heart    16.225 Adult VirginFemale Spermatheca    43.6 Adult InseminatedFemale Spermatheca    41.3 Adult Ovary    82.2 Adult Testis    20 Adult Male Accessory Gland    15.3 Adult Carcass    29.5 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    87.775 Larval Midgut    14.6 Larval Hindgut    44 Larval Malpighian Tubules    42.8 Larval Fat Body    43.4 Larval Salivary Gland    51 Larval Trachea    23.4 Larval Carcass    37.875 Adult Head    28.5 Adult Eye    18.425 Adult Brain    51.3 Adult Thoracic-Abdominal Ganglion    55.9 Adult Crop    46 Adult Midgut    17.3 Adult Hindgut    24.4 Adult Malpighian Tubules    24 Adult Fat Body    33.8 Adult Salivary Gland    38.9 Adult Heart    16.225 Adult VirginFemale Spermatheca    43.6 Adult InseminatedFemale Spermatheca    41.3 Adult Ovary    82.2 Adult Testis    20 Adult Male Accessory Gland    15.3 Adult Carcass    29.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    87.775 Larval Midgut    14.6 Larval Hindgut    44 Larval Malpighian Tubules    42.8 Larval Fat Body    43.4 Larval Salivary Gland    51 Larval Trachea    23.4 Larval Carcass    37.875 Adult Head    28.5 Adult Eye    18.425 Adult Brain    51.3 Adult Thoracic-Abdominal Ganglion    55.9 Adult Crop    46 Adult Midgut    17.3 Adult Hindgut    24.4 Adult Malpighian Tubules    24 Adult Fat Body    33.8 Adult Salivary Gland    38.9 Adult Heart    16.225 Adult VirginFemale Spermatheca    43.6 Adult InseminatedFemale Spermatheca    41.3 Adult Ovary    82.2 Adult Testis    20 Adult Male Accessory Gland    15.3 Adult Carcass    29.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    87.775 Larval Midgut    14.6 Larval Hindgut    44 Larval Malpighian Tubules    42.8 Larval Fat Body    43.4 Larval Salivary Gland    51 Larval Trachea    23.4 Larval Carcass    37.875 Adult Head    28.5 Adult Eye    18.425 Adult Brain    51.3 Adult Thoracic-Abdominal Ganglion    55.9 Adult Crop    46 Adult Midgut    17.3 Adult Hindgut    24.4 Adult Malpighian Tubules    24 Adult Fat Body    33.8 Adult Salivary Gland    38.9 Adult Heart    16.225 Adult VirginFemale Spermatheca    43.6 Adult InseminatedFemale Spermatheca    41.3 Adult Ovary    82.2 Adult Testis    20 Adult Male Accessory Gland    15.3 Adult Carcass    29.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    28.5   NA  Eye    no informative data   NA  Brain    51.3   87.775  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    55.9   NA  Crop    46   no informative data  Midgut    no informative data   44  Hindgut    24.4   42.8  Malpighian Tubules    no informative data   43.4  Fat Body    33.8   51  Salivary Gland    no informative data   NA  Heart    16.225   23.4  Trachea    NA   NA  VirginFemale Spermatheca    43.6   NA  InseminatedFemale Spermatheca    41.3   NA  Ovary    82.2   NA  Testis    20   NA  Male Accessory Gland    no informative data   37.875  Carcass    29.5 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    111 central nervous system, larvae L3    92 central nervous system, pupae P8    53 head, virgin 1-day female    61 head, virgin 4-day female    69 head, virgin 20-day female    70 head, mated 1-day female    58 head, mated 4-day female    51 head, mated 20-day female    56 head, mated 1-day male    71 head, mated 4-day male    61 head, mated 20-day male    70 salivary gland, larvae L3 wandering    40 salivary gland, white prepupae    147 digestive system, larvae L3 wandering    109 digestive system, 1-day adult    58 digestive system, 4-day adult    63 digestive system, 20-day adult    58 fat body, larvae L3 wandering    39 fat body, white prepupae    82 fat body, pupae P8    41 carcass, larvae L3 wandering    100 carcass, 1-day adult    54 carcass, 4-day adult    67 carcass, 20-day adult    72 ovary, virgin 4-day female    220 ovary, mated 4-day female    188 testis, mated 4-day male    105 accessory gland, mated 4-day male    42 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (111) central nervous system, larvae L3  (92) central nervous system, pupae P8  (53) head, virgin 1-day female  (61) head, virgin 4-day female  (69) head, virgin 20-day female  (70) head, mated 1-day female  (58) head, mated 4-day female  (51) head, mated 20-day female  (56) head, mated 1-day male  (71) head, mated 4-day male  (61) head, mated 20-day male  (70) salivary gland, larvae L3 wandering  (40) salivary gland, white prepupae  (147) digestive system, larvae L3 wandering  (109) digestive system, 1-day adult  (58) digestive system, 4-day adult  (63) digestive system, 20-day adult  (58) fat body, larvae L3 wandering  (39) fat body, white prepupae  (82) fat body, pupae P8  (41) carcass, larvae L3 wandering  (100) carcass, 1-day adult  (54) carcass, 4-day adult  (67) carcass, 20-day adult  (72) ovary, virgin 4-day female  (220) ovary, mated 4-day female  (188) testis, mated 4-day male  (105) accessory gland, mated 4-day male  (42) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (111) central nervous system, larvae L3    92 central nervous system, pupae P8    53 head, virgin 1-day female    61 head, virgin 4-day female    69 head, virgin 20-day female    70 head, mated 1-day female    58 head, mated 4-day female    51 head, mated 20-day female    56 head, mated 1-day male    71 head, mated 4-day male    61 head, mated 20-day male    70 salivary gland, larvae L3 wandering    40 salivary gland, white prepupae  (147) digestive system, larvae L3 wandering  (109) digestive system, 1-day adult    58 digestive system, 4-day adult    63 digestive system, 20-day adult    58 fat body, larvae L3 wandering    39 fat body, white prepupae    82 fat body, pupae P8    41 carcass, larvae L3 wandering    100 carcass, 1-day adult    54 carcass, 4-day adult    67 carcass, 20-day adult    72 ovary, virgin 4-day female  (220) ovary, mated 4-day female  (188) testis, mated 4-day male  105 accessory gland, mated 4-day male    42 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    111 central nervous system, larvae L3    92 central nervous system, pupae P8    53 head, virgin 1-day female    61 head, virgin 4-day female    69 head, virgin 20-day female    70 head, mated 1-day female    58 head, mated 4-day female    51 head, mated 20-day female    56 head, mated 1-day male    71 head, mated 4-day male    61 head, mated 20-day male    70 salivary gland, larvae L3 wandering    40 salivary gland, white prepupae    147 digestive system, larvae L3 wandering    109 digestive system, 1-day adult    58 digestive system, 4-day adult    63 digestive system, 20-day adult    58 fat body, larvae L3 wandering    39 fat body, white prepupae    82 fat body, pupae P8    41 carcass, larvae L3 wandering    100 carcass, 1-day adult    54 carcass, 4-day adult    67 carcass, 20-day adult    72 ovary, virgin 4-day female    220 ovary, mated 4-day female    188 testis, mated 4-day male    105 accessory gland, mated 4-day male    42 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    111 central nervous system, larvae L3    92 central nervous system, pupae P8    53 head, virgin 1-day female    61 head, virgin 4-day female    69 head, virgin 20-day female    70 head, mated 1-day female    58 head, mated 4-day female    51 head, mated 20-day female    56 head, mated 1-day male    71 head, mated 4-day male    61 head, mated 20-day male    70 salivary gland, larvae L3 wandering    40 salivary gland, white prepupae    147 digestive system, larvae L3 wandering    109 digestive system, 1-day adult    58 digestive system, 4-day adult    63 digestive system, 20-day adult    58 fat body, larvae L3 wandering    39 fat body, white prepupae    82 fat body, pupae P8    41 carcass, larvae L3 wandering    100 carcass, 1-day adult    54 carcass, 4-day adult    67 carcass, 20-day adult    72 ovary, virgin 4-day female    220 ovary, mated 4-day female    188 testis, mated 4-day male    105 accessory gland, mated 4-day male    42 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (111) central nervous system, larvae L3  (92) central nervous system, pupae P8  (53) head, virgin 1-day female  (61) head, virgin 4-day female  (69) head, virgin 20-day female  (70) head, mated 1-day female  (58) head, mated 4-day female  (51) head, mated 20-day female  (56) head, mated 1-day male  (71) head, mated 4-day male  (61) head, mated 20-day male  (70) salivary gland, larvae L3 wandering  (40) salivary gland, white prepupae  (147) digestive system, larvae L3 wandering  (109) digestive system, 1-day adult  (58) digestive system, 4-day adult  (63) digestive system, 20-day adult  (58) fat body, larvae L3 wandering  (39) fat body, white prepupae  (82) fat body, pupae P8  (41) carcass, larvae L3 wandering  (100) carcass, 1-day adult  (54) carcass, 4-day adult  (67) carcass, 20-day adult  (72) ovary, virgin 4-day female  (220) ovary, mated 4-day female  (188) testis, mated 4-day male  (105) accessory gland, mated 4-day male  (42) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  111 central nervous system, larvae L3    92 central nervous system, pupae P8    53 head, virgin 1-day female    61 head, virgin 4-day female    69 head, virgin 20-day female    70 head, mated 1-day female    58 head, mated 4-day female    51 head, mated 20-day female    56 head, mated 1-day male    71 head, mated 4-day male    61 head, mated 20-day male    70 salivary gland, larvae L3 wandering    40 salivary gland, white prepupae  (147) digestive system, larvae L3 wandering  109 digestive system, 1-day adult    58 digestive system, 4-day adult    63 digestive system, 20-day adult    58 fat body, larvae L3 wandering    39 fat body, white prepupae    82 fat body, pupae P8    41 carcass, larvae L3 wandering    100 carcass, 1-day adult    54 carcass, 4-day adult    67 carcass, 20-day adult    72 ovary, virgin 4-day female  (220) ovary, mated 4-day female  (188) testis, mated 4-day male  105 accessory gland, mated 4-day male    42 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    111 central nervous system, larvae L3    92 central nervous system, pupae P8    53 head, virgin 1-day female    61 head, virgin 4-day female    69 head, virgin 20-day female    70 head, mated 1-day female    58 head, mated 4-day female    51 head, mated 20-day female    56 head, mated 1-day male    71 head, mated 4-day male    61 head, mated 20-day male    70 salivary gland, larvae L3 wandering    40 salivary gland, white prepupae    147 digestive system, larvae L3 wandering    109 digestive system, 1-day adult    58 digestive system, 4-day adult    63 digestive system, 20-day adult    58 fat body, larvae L3 wandering    39 fat body, white prepupae    82 fat body, pupae P8    41 carcass, larvae L3 wandering    100 carcass, 1-day adult    54 carcass, 4-day adult    67 carcass, 20-day adult    72 ovary, virgin 4-day female    220 ovary, mated 4-day female    188 testis, mated 4-day male    105 accessory gland, mated 4-day male    42 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of high expression. Peak expression observed within 00-12 and 18-24 hour embryonic stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    205 embryo 02-04hr    315 embryo 04-06hr    231 embryo 06-08hr    132 embryo 08-10hr    144 embryo 10-12hr    138 embryo 12-14hr    126 embryo 14-16hr    130 embryo 16-18hr    125 embryo 18-20hr    93 embryo 20-22hr    174 embryo 22-24hr    150 larva L1    93 larva L2    82 larva L3 12hr old    72 larva L3 puffstage 1-2    67 larva L3 puffstage 3-6    99 larva L3 puffstage 7-9    115 white prepupae new    115 white prepupae 12hr    90 white prepupae 24hr    90 pupae 2d postWPP    83 pupae 3d postWPP    67 pupae 4d postWPP    60 adult male 01day    73 adult male 05day    85 adult male 30day    70 adult female 01day    108 adult female 05day    156 adult female 30day    149 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (205) embryo 02-04hr  (315) embryo 04-06hr  (231) embryo 06-08hr  (132) embryo 08-10hr  (144) embryo 10-12hr  (138) embryo 12-14hr  (126) embryo 14-16hr  (130) embryo 16-18hr  (125) embryo 18-20hr  (93) embryo 20-22hr  (174) embryo 22-24hr  (150) larva L1  (93) larva L2  (82) larva L3 12hr old  (72) larva L3 puffstage 1-2  (67) larva L3 puffstage 3-6  (99) larva L3 puffstage 7-9  (115) white prepupae new  (115) white prepupae 12hr  (90) white prepupae 24hr  (90) pupae 2d postWPP  (83) pupae 3d postWPP  (67) pupae 4d postWPP  (60) adult male 01day  (73) adult male 05day  (85) adult male 30day  (70) adult female 01day  (108) adult female 05day  (156) adult female 30day  (149) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (205) embryo 02-04hr  (315) embryo 04-06hr  (231) embryo 06-08hr  (132) embryo 08-10hr  (144) embryo 10-12hr  (138) embryo 12-14hr  (126) embryo 14-16hr  (130) embryo 16-18hr  (125) embryo 18-20hr    93 embryo 20-22hr  (174) embryo 22-24hr  (150) larva L1    93 larva L2    82 larva L3 12hr old    72 larva L3 puffstage 1-2    67 larva L3 puffstage 3-6    99 larva L3 puffstage 7-9  (115) white prepupae new  (115) white prepupae 12hr    90 white prepupae 24hr    90 pupae 2d postWPP    83 pupae 3d postWPP    67 pupae 4d postWPP    60 adult male 01day    73 adult male 05day    85 adult male 30day    70 adult female 01day  (108) adult female 05day  (156) adult female 30day  (149) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    205 embryo 02-04hr    315 embryo 04-06hr    231 embryo 06-08hr    132 embryo 08-10hr    144 embryo 10-12hr    138 embryo 12-14hr    126 embryo 14-16hr    130 embryo 16-18hr    125 embryo 18-20hr    93 embryo 20-22hr    174 embryo 22-24hr    150 larva L1    93 larva L2    82 larva L3 12hr old    72 larva L3 puffstage 1-2    67 larva L3 puffstage 3-6    99 larva L3 puffstage 7-9    115 white prepupae new    115 white prepupae 12hr    90 white prepupae 24hr    90 pupae 2d postWPP    83 pupae 3d postWPP    67 pupae 4d postWPP    60 adult male 01day    73 adult male 05day    85 adult male 30day    70 adult female 01day    108 adult female 05day    156 adult female 30day    149 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    205 embryo 02-04hr    315 embryo 04-06hr    231 embryo 06-08hr    132 embryo 08-10hr    144 embryo 10-12hr    138 embryo 12-14hr    126 embryo 14-16hr    130 embryo 16-18hr    125 embryo 18-20hr    93 embryo 20-22hr    174 embryo 22-24hr    150 larva L1    93 larva L2    82 larva L3 12hr old    72 larva L3 puffstage 1-2    67 larva L3 puffstage 3-6    99 larva L3 puffstage 7-9    115 white prepupae new    115 white prepupae 12hr    90 white prepupae 24hr    90 pupae 2d postWPP    83 pupae 3d postWPP    67 pupae 4d postWPP    60 adult male 01day    73 adult male 05day    85 adult male 30day    70 adult female 01day    108 adult female 05day    156 adult female 30day    149 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (205) embryo 02-04hr  (315) embryo 04-06hr  (231) embryo 06-08hr  (132) embryo 08-10hr  (144) embryo 10-12hr  (138) embryo 12-14hr  (126) embryo 14-16hr  (130) embryo 16-18hr  (125) embryo 18-20hr  (93) embryo 20-22hr  (174) embryo 22-24hr  (150) larva L1  (93) larva L2  (82) larva L3 12hr old  (72) larva L3 puffstage 1-2  (67) larva L3 puffstage 3-6  (99) larva L3 puffstage 7-9  (115) white prepupae new  (115) white prepupae 12hr  (90) white prepupae 24hr  (90) pupae 2d postWPP  (83) pupae 3d postWPP  (67) pupae 4d postWPP  (60) adult male 01day  (73) adult male 05day  (85) adult male 30day  (70) adult female 01day  (108) adult female 05day  (156) adult female 30day  (149) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (205) embryo 02-04hr  (315) embryo 04-06hr  (231) embryo 06-08hr  132 embryo 08-10hr  (144) embryo 10-12hr  138 embryo 12-14hr  126 embryo 14-16hr  130 embryo 16-18hr  125 embryo 18-20hr    93 embryo 20-22hr  (174) embryo 22-24hr  (150) larva L1    93 larva L2    82 larva L3 12hr old    72 larva L3 puffstage 1-2    67 larva L3 puffstage 3-6    99 larva L3 puffstage 7-9  115 white prepupae new  115 white prepupae 12hr    90 white prepupae 24hr    90 pupae 2d postWPP    83 pupae 3d postWPP    67 pupae 4d postWPP    60 adult male 01day    73 adult male 05day    85 adult male 30day    70 adult female 01day  108 adult female 05day  (156) adult female 30day  (149) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    205 embryo 02-04hr    315 embryo 04-06hr    231 embryo 06-08hr    132 embryo 08-10hr    144 embryo 10-12hr    138 embryo 12-14hr    126 embryo 14-16hr    130 embryo 16-18hr    125 embryo 18-20hr    93 embryo 20-22hr    174 embryo 22-24hr    150 larva L1    93 larva L2    82 larva L3 12hr old    72 larva L3 puffstage 1-2    67 larva L3 puffstage 3-6    99 larva L3 puffstage 7-9    115 white prepupae new    115 white prepupae 12hr    90 white prepupae 24hr    90 pupae 2d postWPP    83 pupae 3d postWPP    67 pupae 4d postWPP    60 adult male 01day    73 adult male 05day    85 adult male 30day    70 adult female 01day    108 adult female 05day    156 adult female 30day    149 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    212 Schneider line 2 Sg4    93 embryonic 1182-4H    85 embryonic GM2    79 embryonic Kc167    68 embryonic S1    116 embryonic S3    130 leg disc CME L1    121 wing disc CME-W2    107 wing disc ML-DmD8    77 wing disc ML-DmD9    101 wing disc ML-DmD16-c3    107 wing disc ML-DmD21    74 wing disc ML-DmD32    108 haltere disc ML-DmD17-c3    115 eye-antennal disc ML-DmD11    120 antennal disc ML-DmD20-c5    108 mixed discs ML-DmD4-c1    114 CNS ML-DmBG1-c1    101 CNS ML-DmBG2-c2    85 tumorous blood cells mbn2    73 ovary fGS/OSS    89 ovary OSC    97 ovary OSS    46 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (212) Schneider line 2 Sg4  (93) embryonic 1182-4H  (85) embryonic GM2  (79) embryonic Kc167  (68) embryonic S1  (116) embryonic S3  (130) leg disc CME L1  (121) wing disc CME-W2  (107) wing disc ML-DmD8  (77) wing disc ML-DmD9  (101) wing disc ML-DmD16-c3  (107) wing disc ML-DmD21  (74) wing disc ML-DmD32  (108) haltere disc ML-DmD17-c3  (115) eye-antennal disc ML-DmD11  (120) antennal disc ML-DmD20-c5  (108) mixed discs ML-DmD4-c1  (114) CNS ML-DmBG1-c1  (101) CNS ML-DmBG2-c2  (85) tumorous blood cells mbn2  (73) ovary fGS/OSS  (89) ovary OSC  (97) ovary OSS  (46) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (212) Schneider line 2 Sg4    93 embryonic 1182-4H    85 embryonic GM2    79 embryonic Kc167    68 embryonic S1  (116) embryonic S3  (130) leg disc CME L1  (121) wing disc CME-W2  107 wing disc ML-DmD8    77 wing disc ML-DmD9  101 wing disc ML-DmD16-c3  107 wing disc ML-DmD21    74 wing disc ML-DmD32  (108) haltere disc ML-DmD17-c3  (115) eye-antennal disc ML-DmD11  (120) antennal disc ML-DmD20-c5  (108) mixed discs ML-DmD4-c1  (114) CNS ML-DmBG1-c1  101 CNS ML-DmBG2-c2    85 tumorous blood cells mbn2    73 ovary fGS/OSS    89 ovary OSC    97 ovary OSS    46 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    212 Schneider line 2 Sg4    93 embryonic 1182-4H    85 embryonic GM2    79 embryonic Kc167    68 embryonic S1    116 embryonic S3    130 leg disc CME L1    121 wing disc CME-W2    107 wing disc ML-DmD8    77 wing disc ML-DmD9    101 wing disc ML-DmD16-c3    107 wing disc ML-DmD21    74 wing disc ML-DmD32    108 haltere disc ML-DmD17-c3    115 eye-antennal disc ML-DmD11    120 antennal disc ML-DmD20-c5    108 mixed discs ML-DmD4-c1    114 CNS ML-DmBG1-c1    101 CNS ML-DmBG2-c2    85 tumorous blood cells mbn2    73 ovary fGS/OSS    89 ovary OSC    97 ovary OSS    46 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    212 Schneider line 2 Sg4    93 embryonic 1182-4H    85 embryonic GM2    79 embryonic Kc167    68 embryonic S1    116 embryonic S3    130 leg disc CME L1    121 wing disc CME-W2    107 wing disc ML-DmD8    77 wing disc ML-DmD9    101 wing disc ML-DmD16-c3    107 wing disc ML-DmD21    74 wing disc ML-DmD32    108 haltere disc ML-DmD17-c3    115 eye-antennal disc ML-DmD11    120 antennal disc ML-DmD20-c5    108 mixed discs ML-DmD4-c1    114 CNS ML-DmBG1-c1    101 CNS ML-DmBG2-c2    85 tumorous blood cells mbn2    73 ovary fGS/OSS    89 ovary OSC    97 ovary OSS    46 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (212) Schneider line 2 Sg4  (93) embryonic 1182-4H  (85) embryonic GM2  (79) embryonic Kc167  (68) embryonic S1  (116) embryonic S3  (130) leg disc CME L1  (121) wing disc CME-W2  (107) wing disc ML-DmD8  (77) wing disc ML-DmD9  (101) wing disc ML-DmD16-c3  (107) wing disc ML-DmD21  (74) wing disc ML-DmD32  (108) haltere disc ML-DmD17-c3  (115) eye-antennal disc ML-DmD11  (120) antennal disc ML-DmD20-c5  (108) mixed discs ML-DmD4-c1  (114) CNS ML-DmBG1-c1  (101) CNS ML-DmBG2-c2  (85) tumorous blood cells mbn2  (73) ovary fGS/OSS  (89) ovary OSC  (97) ovary OSS  (46) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (212) Schneider line 2 Sg4    93 embryonic 1182-4H    85 embryonic GM2    79 embryonic Kc167    68 embryonic S1  116 embryonic S3  130 leg disc CME L1  121 wing disc CME-W2  107 wing disc ML-DmD8    77 wing disc ML-DmD9  101 wing disc ML-DmD16-c3  107 wing disc ML-DmD21    74 wing disc ML-DmD32  108 haltere disc ML-DmD17-c3  115 eye-antennal disc ML-DmD11  120 antennal disc ML-DmD20-c5  108 mixed discs ML-DmD4-c1  114 CNS ML-DmBG1-c1  101 CNS ML-DmBG2-c2    85 tumorous blood cells mbn2    73 ovary fGS/OSS    89 ovary OSC    97 ovary OSS    46 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    212 Schneider line 2 Sg4    93 embryonic 1182-4H    85 embryonic GM2    79 embryonic Kc167    68 embryonic S1    116 embryonic S3    130 leg disc CME L1    121 wing disc CME-W2    107 wing disc ML-DmD8    77 wing disc ML-DmD9    101 wing disc ML-DmD16-c3    107 wing disc ML-DmD21    74 wing disc ML-DmD32    108 haltere disc ML-DmD17-c3    115 eye-antennal disc ML-DmD11    120 antennal disc ML-DmD20-c5    108 mixed discs ML-DmD4-c1    114 CNS ML-DmBG1-c1    101 CNS ML-DmBG2-c2    85 tumorous blood cells mbn2    73 ovary fGS/OSS    89 ovary OSC    97 ovary OSS    46 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    66 cold shock, 4-day adult    52 heat shock, 4-day adult    107 Cadmium 50 mM 6 hrs, larvae L3    68 Cadmium 50 mM 12 hrs, larvae L3    99 Cadmium 50 mM 48 hrs, 4-day adult    96 Cadmium 100 mM 48 hrs, 4-day adult    141 Copper 0.5 mM 12 hrs, larvae L3    50 Copper 15 mM 48 hrs, 4-day adult    87 Zinc 5 mM 12 hrs, larvae L3    44 Zinc 4.5 mM 48 hrs, 4-day adult    75 Ethanol 2.5% 3 hrs, larvae L3    145 Ethanol 5% 3 hrs, larvae L3    78 Ethanol 10% 3 hrs, larvae L3    69 Caffeine 1.5 mg/ml 4 hrs, larvae L3    74 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    149 Caffeine 25 mg/ml 48 hrs, 4-day adult    57 Paraquat 5 mM 48 hrs, 4-day adult    143 Paraquat 10 mM 48 hrs, 4-day adult    117 Rotenone 2 μg 12 hrs, larvae L3    85 Rotenone 8 μg 12 hrs, larvae L3    67 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (66) cold shock, 4-day adult  (52) heat shock, 4-day adult  (107) Cadmium 50 mM 6 hrs, larvae L3  (68) Cadmium 50 mM 12 hrs, larvae L3  (99) Cadmium 50 mM 48 hrs, 4-day adult  (96) Cadmium 100 mM 48 hrs, 4-day adult  (141) Copper 0.5 mM 12 hrs, larvae L3  (50) Copper 15 mM 48 hrs, 4-day adult  (87) Zinc 5 mM 12 hrs, larvae L3  (44) Zinc 4.5 mM 48 hrs, 4-day adult  (75) Ethanol 2.5% 3 hrs, larvae L3  (145) Ethanol 5% 3 hrs, larvae L3  (78) Ethanol 10% 3 hrs, larvae L3  (69) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (74) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (149) Caffeine 25 mg/ml 48 hrs, 4-day adult  (57) Paraquat 5 mM 48 hrs, 4-day adult  (143) Paraquat 10 mM 48 hrs, 4-day adult  (117) Rotenone 2 μg 12 hrs, larvae L3  (85) Rotenone 8 μg 12 hrs, larvae L3  (67) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    66 cold shock, 4-day adult    52 heat shock, 4-day adult  107 Cadmium 50 mM 6 hrs, larvae L3    68 Cadmium 50 mM 12 hrs, larvae L3    99 Cadmium 50 mM 48 hrs, 4-day adult    96 Cadmium 100 mM 48 hrs, 4-day adult  (141) Copper 0.5 mM 12 hrs, larvae L3    50 Copper 15 mM 48 hrs, 4-day adult    87 Zinc 5 mM 12 hrs, larvae L3    44 Zinc 4.5 mM 48 hrs, 4-day adult    75 Ethanol 2.5% 3 hrs, larvae L3  (145) Ethanol 5% 3 hrs, larvae L3    78 Ethanol 10% 3 hrs, larvae L3    69 Caffeine 1.5 mg/ml 4 hrs, larvae L3    74 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (149) Caffeine 25 mg/ml 48 hrs, 4-day adult    57 Paraquat 5 mM 48 hrs, 4-day adult  (143) Paraquat 10 mM 48 hrs, 4-day adult  (117) Rotenone 2 μg 12 hrs, larvae L3    85 Rotenone 8 μg 12 hrs, larvae L3    67 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    66 cold shock, 4-day adult    52 heat shock, 4-day adult    107 Cadmium 50 mM 6 hrs, larvae L3    68 Cadmium 50 mM 12 hrs, larvae L3    99 Cadmium 50 mM 48 hrs, 4-day adult    96 Cadmium 100 mM 48 hrs, 4-day adult    141 Copper 0.5 mM 12 hrs, larvae L3    50 Copper 15 mM 48 hrs, 4-day adult    87 Zinc 5 mM 12 hrs, larvae L3    44 Zinc 4.5 mM 48 hrs, 4-day adult    75 Ethanol 2.5% 3 hrs, larvae L3    145 Ethanol 5% 3 hrs, larvae L3    78 Ethanol 10% 3 hrs, larvae L3    69 Caffeine 1.5 mg/ml 4 hrs, larvae L3    74 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    149 Caffeine 25 mg/ml 48 hrs, 4-day adult    57 Paraquat 5 mM 48 hrs, 4-day adult    143 Paraquat 10 mM 48 hrs, 4-day adult    117 Rotenone 2 μg 12 hrs, larvae L3    85 Rotenone 8 μg 12 hrs, larvae L3    67 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    66 cold shock, 4-day adult    52 heat shock, 4-day adult    107 Cadmium 50 mM 6 hrs, larvae L3    68 Cadmium 50 mM 12 hrs, larvae L3    99 Cadmium 50 mM 48 hrs, 4-day adult    96 Cadmium 100 mM 48 hrs, 4-day adult    141 Copper 0.5 mM 12 hrs, larvae L3    50 Copper 15 mM 48 hrs, 4-day adult    87 Zinc 5 mM 12 hrs, larvae L3    44 Zinc 4.5 mM 48 hrs, 4-day adult    75 Ethanol 2.5% 3 hrs, larvae L3    145 Ethanol 5% 3 hrs, larvae L3    78 Ethanol 10% 3 hrs, larvae L3    69 Caffeine 1.5 mg/ml 4 hrs, larvae L3    74 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    149 Caffeine 25 mg/ml 48 hrs, 4-day adult    57 Paraquat 5 mM 48 hrs, 4-day adult    143 Paraquat 10 mM 48 hrs, 4-day adult    117 Rotenone 2 μg 12 hrs, larvae L3    85 Rotenone 8 μg 12 hrs, larvae L3    67 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (66) cold shock, 4-day adult  (52) heat shock, 4-day adult  (107) Cadmium 50 mM 6 hrs, larvae L3  (68) Cadmium 50 mM 12 hrs, larvae L3  (99) Cadmium 50 mM 48 hrs, 4-day adult  (96) Cadmium 100 mM 48 hrs, 4-day adult  (141) Copper 0.5 mM 12 hrs, larvae L3  (50) Copper 15 mM 48 hrs, 4-day adult  (87) Zinc 5 mM 12 hrs, larvae L3  (44) Zinc 4.5 mM 48 hrs, 4-day adult  (75) Ethanol 2.5% 3 hrs, larvae L3  (145) Ethanol 5% 3 hrs, larvae L3  (78) Ethanol 10% 3 hrs, larvae L3  (69) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (74) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (149) Caffeine 25 mg/ml 48 hrs, 4-day adult  (57) Paraquat 5 mM 48 hrs, 4-day adult  (143) Paraquat 10 mM 48 hrs, 4-day adult  (117) Rotenone 2 μg 12 hrs, larvae L3  (85) Rotenone 8 μg 12 hrs, larvae L3  (67) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    66 cold shock, 4-day adult    52 heat shock, 4-day adult  107 Cadmium 50 mM 6 hrs, larvae L3    68 Cadmium 50 mM 12 hrs, larvae L3    99 Cadmium 50 mM 48 hrs, 4-day adult    96 Cadmium 100 mM 48 hrs, 4-day adult  141 Copper 0.5 mM 12 hrs, larvae L3    50 Copper 15 mM 48 hrs, 4-day adult    87 Zinc 5 mM 12 hrs, larvae L3    44 Zinc 4.5 mM 48 hrs, 4-day adult    75 Ethanol 2.5% 3 hrs, larvae L3  (145) Ethanol 5% 3 hrs, larvae L3    78 Ethanol 10% 3 hrs, larvae L3    69 Caffeine 1.5 mg/ml 4 hrs, larvae L3    74 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (149) Caffeine 25 mg/ml 48 hrs, 4-day adult    57 Paraquat 5 mM 48 hrs, 4-day adult  143 Paraquat 10 mM 48 hrs, 4-day adult  117 Rotenone 2 μg 12 hrs, larvae L3    85 Rotenone 8 μg 12 hrs, larvae L3    67 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    66 cold shock, 4-day adult    52 heat shock, 4-day adult    107 Cadmium 50 mM 6 hrs, larvae L3    68 Cadmium 50 mM 12 hrs, larvae L3    99 Cadmium 50 mM 48 hrs, 4-day adult    96 Cadmium 100 mM 48 hrs, 4-day adult    141 Copper 0.5 mM 12 hrs, larvae L3    50 Copper 15 mM 48 hrs, 4-day adult    87 Zinc 5 mM 12 hrs, larvae L3    44 Zinc 4.5 mM 48 hrs, 4-day adult    75 Ethanol 2.5% 3 hrs, larvae L3    145 Ethanol 5% 3 hrs, larvae L3    78 Ethanol 10% 3 hrs, larvae L3    69 Caffeine 1.5 mg/ml 4 hrs, larvae L3    74 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    149 Caffeine 25 mg/ml 48 hrs, 4-day adult    57 Paraquat 5 mM 48 hrs, 4-day adult    143 Paraquat 10 mM 48 hrs, 4-day adult    117 Rotenone 2 μg 12 hrs, larvae L3    85 Rotenone 8 μg 12 hrs, larvae L3    67 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_17 mE1_20_mRNA_expression_cluster_10
External Data & Images
Linkouts	BDGP expression data • LD13917 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0027338 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9423-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Kap-α3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4pnr-MD237 Kap-α3GD14213 lethal (with Kap-α3D93) Kap-α3D165 lethal (with Kap-α3D165) Kap-α3D93 lethal | heat sensitive, with Scer\GAL4e22c Kap-α3Scer\UAS.cMa lethal | larval stage Kap-α3D93 Kap-α3D165 lethal | larval stage, with Scer\GAL4da.G32 Kap-α3GD14213 lethal | larval stage (with Df(3R)by416) Kap-α3D93 Kap-α3D165 lethal | larval stage (with Df(3R)GB104) Kap-α317-7 Kap-α3D93 Kap-α3D165 Kap-α3w73 lethal | larval stage (with Kap-α317-7) Kap-α3D93 Kap-α3D165 lethal | larval stage (with Kap-α3D93) Kap-α317-7 Kap-α3w73 lethal | larval stage (with Kap-α3D165) Kap-α317-7 Kap-α3w73 lethal | larval stage (with Kap-α3w73) Kap-α3D93 Kap-α3D165 partially lethal - majority die, with Scer\GAL4pnr-MD237 Kap-α3GD14213 viable Kap-α3S033513 Sterility Allele fertile Kap-α3D93 Kap-α3D165 Kap-α3S033513 fertile | female (with Kap-α3D93) Kap-α3D165 fertile | female (with Kap-α3D165) Kap-α3D93 Other Phenotypes Allele neuroanatomy defective Kap-α317-76 phototaxis defective | somatic clone Kap-α316-8 Kap-α317-76 Kap-α3D93 visible, with Scer\GAL4pnr-MD237 Kap-α3GD14213 visible | somatic clone Kap-α3D93 wild-type Kap-α3+t9 Phenotype manifest in Allele eye | somatic clone Kap-α3D93 interommatidial bristle | somatic clone Kap-α3D93 mesothoracic tergum, with Scer\GAL4pnr-MD237 Kap-α3GD14213 ommatidium | somatic clone Kap-α3D93 photoreceptor cell R7 Kap-α317-76 photoreceptor cell R7 | somatic clone Kap-α3D93 Kap-α316-8 Kap-α317-76 rhabdomere | somatic clone Kap-α3D93 tergite, with Scer\GAL4e22c Kap-α3Scer\UAS.cMa tormogen cell, with Scer\GAL4pnr-MD237 Kap-α3GD14213 tormogen cell | somatic clone Kap-α3D93
Classical Alleles ( 9 )
For All Classical Alleles Show
Allele of Kap-α3 Class Mutagen Stocks Known lesion Kap-α3D93 loss of function allele Delta2-3 1 Yes Kap-α3EY02572 P-element activity 1 -- Kap-α3G8397 P-element activity 1 -- Kap-α316-8 0 -- Kap-α317-76 0 -- Kap-α317-7 0 Yes Kap-α3D165 loss of function allele Delta2-3 0 Yes Kap-α3S033513 Delta2-3 P-element activity 0 -- Kap-α3w73 0 Yes
Alleles Carried on Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Kap-α3 Class Mutagen Stocks Known lesion Kap-α3GD14213 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Kap-α3JF02686 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Kap-α3KK101268 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Kap-α3Scer\UAS.P\T.cMa in vitro construct - regulatory fusion 1 Yes Kap-α3+t9 in vitro construct - genomic fragment 0 Yes Kap-α3-UTR.Scer\UAS.P\T in vitro construct - regulatory fusion 0 Yes Kap-α3pRD4.1 in vitro construct - deletion 0 Yes Kap-α3Scer\UAS.cMa in vitro construct - regulatory fusion 0 Yes Kap-α3Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)by62 (Szeged Stock Center, 1998-, Deak et al., 1997) Df(3R)by416 (Mason et al., 2003) Df(3R)Exel6153 (Ryder, 2004.4.26) Df(3R)Exel6264 (Ryder, 2004.4.26) Df(3R)GB104 (Mason et al., 2003)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{UAS-Kap-α3.M} NA P{UASp-Kap-α3.M} NA P{UASp-Kap-α3.-UTR} NA characterization construct P{imp-α3+} NA P{imp-α3-} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}Kap-α3S033513 No insertion of mobile activating element P{EP}Kap-α3G8397 NA P{EPgy2}Kap-α3EY02572 NA
Gene Ontology: Function, Process & Cellular Component ( 9 unique terms )
Terms Based on Experimental Evidence ( 4 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with Myo10A (Liu et al., 2008)
Biological Process
CV term Evidence References
mitotic G2 DNA damage checkpoint inferred from genetic interaction with nbs (Kondo and Perrimon, 2011) positive regulation of NFAT protein import into nucleus inferred from mutant phenotype (Gwack et al., 2007) response to UV inferred from direct assay (Ting et al., 2007)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
protein transmembrane transporter activity non-traceable author statement (Mason, 1998.6.29) protein transporter activity inferred from sequence or structural similarity with human KPNA3 (FlyBase, 1992-)
Biological Process
CV term Evidence References
protein import into nucleus inferred from sequence or structural similarity with human KPNA3 (FlyBase, 1992-) non-traceable author statement (Dockendorff, 1999.5.19, Mason, 1998.6.29, Cotterill, 1999.4.1)
Cellular Component
CV term Evidence References
cytoplasm inferred from electronic annotation with InterPro:IPR002652 (FlyBase Curators et al., 2004-) nuclear pore inferred from sequence or structural similarity with human KPNA3 (FlyBase, 1992-) non-traceable author statement (Dockendorff, 1999.5.19, Mason, 1998.6.29, Cotterill, 1999.4.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Kap-α3 - 5-HT7 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - AR-2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - Aats-glupro experimental knowledge based (Guruharsha et al., 2011) Kap-α3 - Aats-his anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - Ada anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - Arp10 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - Ate1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - Atpα experimental knowledge based (Guruharsha et al., 2011) Kap-α3 - CG10131 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - CG10175 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - CG10425 experimental knowledge based (Guruharsha et al., 2011) Kap-α3 - CG10495 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - CG10660 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - CG11060 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - CG11876 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - CG12129 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - CG12262 experimental knowledge based (Guruharsha et al., 2011) Kap-α3 - CG12264 experimental knowledge based (Guruharsha et al., 2011) Kap-α3 - CG13865 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - CG13995 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - CG14024 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - CG1416 experimental knowledge based (Guruharsha et al., 2011) Kap-α3 - CG1444 experimental knowledge based (Guruharsha et al., 2011) Kap-α3 - CG15484 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - CG15643 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - CG17242 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - CG17259 experimental knowledge based (Guruharsha et al., 2011) Kap-α3 - CG1774 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - CG1907 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - CG2010 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - CG2064 experimental knowledge based (Guruharsha et al., 2011) Kap-α3 - CG2789 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - CG2931 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - CG3091 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - CG31051 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - CG31522 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - CG31523 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - CG33303 experimental knowledge based (Guruharsha et al., 2011) Kap-α3 - CG33970 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - CG3570 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - CG4169 experimental knowledge based (Guruharsha et al., 2011) Kap-α3 - CG4338 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - CG5027 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - CG5660 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - CG5718 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - CG5961 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - CG6073 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - CG6178 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - CG6453 experimental knowledge based (Guruharsha et al., 2011) Kap-α3 - CG6652 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - CG7033 experimental knowledge based (Guruharsha et al., 2011) Kap-α3 - CG7655 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - CG8258 experimental knowledge based (Guruharsha et al., 2011) Kap-α3 - CG8368 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - CG8745 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - CG8993 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - CG9231 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - CSN4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - Cct5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - Cctγ experimental knowledge based (Guruharsha et al., 2011) Kap-α3 - Cdc6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - Chc experimental knowledge based (Guruharsha et al., 2011) Kap-α3 - Cnx99A experimental knowledge based (Guruharsha et al., 2011) Kap-α3 - Corp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - Csl4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - Cyp12d1-p experimental knowledge based (Guruharsha et al., 2011) Kap-α3 - Cyp9b2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - EfTuM experimental knowledge based (Guruharsha et al., 2011) Kap-α3 - Ent2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - Esp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - Fatp experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) Kap-α3 - Fmo-2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - Gale experimental knowledge based (Guruharsha et al., 2011) Kap-α3 - Gp93 experimental knowledge based (Guruharsha et al., 2011) Kap-α3 - Gyk anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - Hcf anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - Hip1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - Karyβ3 experimental knowledge based (Guruharsha et al., 2011) Kap-α3 - Kr-h2 experimental knowledge based (Guruharsha et al., 2011) Kap-α3 - M6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - MRP experimental knowledge based (Guruharsha et al., 2011) Kap-α3 - Mcm3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - Mec2 experimental knowledge based (Guruharsha et al., 2011) Kap-α3 - Men anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - Mpcp experimental knowledge based (Guruharsha et al., 2011) Kap-α3 - Mpp6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - Nedd4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - Nup50 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - Ocrl anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - Ost48 experimental knowledge based (Guruharsha et al., 2011) Kap-α3 - OstΔ experimental knowledge based (Guruharsha et al., 2011) Kap-α3 - Past1 experimental knowledge based (Guruharsha et al., 2011) Kap-α3 - Pen experimental knowledge based (Guruharsha et al., 2011) Kap-α3 - Pi4KIIα anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - Pk17E anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - Pp2A-29B experimental knowledge based (Guruharsha et al., 2011) Kap-α3 - Rab18 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - Rac1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - Ran anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - Ranbp9 experimental knowledge based (Guruharsha et al., 2011) Kap-α3 - Rcd6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - RluA-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - Rpp30 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - Sc2 experimental knowledge based (Guruharsha et al., 2011) Kap-α3 - Sec61α experimental knowledge based (Guruharsha et al., 2011) Kap-α3 - Sesn anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - Sk1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - Socs44A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - Sucb experimental knowledge based (Guruharsha et al., 2011) Kap-α3 - Tcp-1ζ experimental knowledge based (Guruharsha et al., 2011) Kap-α3 - Tcp-1η experimental knowledge based (Guruharsha et al., 2011) Kap-α3 - TfIIEα anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - Tg anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - Tsp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - Ugt86Di anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - Vap-33-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - Vps4 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) Kap-α3 - atms anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - bsh anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - dhd anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - frc anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - gk anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - ihog anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - kuk anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - l(1)G0156 experimental knowledge based (Guruharsha et al., 2011) Kap-α3 - l(2)gl anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - l(3)02640 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - mys anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - rho anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - stas anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - tsl anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - wal experimental knowledge based (Guruharsha et al., 2011) Kap-α3 - wcd anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - wds anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kap-α3 - βCop experimental knowledge based (Guruharsha et al., 2011) Kap-α3 - βggt-II anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Kap-α3 allele Gene References Kap-α317-7 Pen (Mason et al., 2003) Kap-α3D93 Pen (Mason et al., 2003) Kap-α3Scer\UAS.cMa Pen (Mason et al., 2002)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 66317 DroID - A comprehensive database of gene and protein interactions. • FBgn0027338 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41158 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • O76522
Orthologs
OrthoDB Orthologs (78) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6BG9FP Dipteran inclusive ortholog search EOG6N5W57 Insect inclusive ortholog search EOG6FQZMV Arthropod inclusive ortholog search EOG6M0CGW Metazoa inclusive ortholog search EOG6GXTF0
Orthologs in Drosophila Species (EOG6BG9FP)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Kap-α3     Drosophila simulans   Dsim\GD20781 Y   Drosophila sechellia   Dsec\GM26241 Y   Drosophila erecta   Dere\GG17355 Y   Drosophila yakuba   Dyak\GE24760 Y   Drosophila ananassae   Dana\GF16531 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA21775 Y   Drosophila persimilis   Dper\GL21493 Y   Drosophila willistoni   Dwil\GK14517 Y   Drosophila virilis   Dvir\GJ10266 Y   Drosophila mojavensis   Dmoj\GI23514 Y   Drosophila grimshawi   Dgri\GH19298 Y
Orthologs in non-Drosophila Dipterans (EOG6N5W57)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL011657   Anopheles gambiae Malaria mosquito  Agam\AGAP001273   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ001179
Orthologs in non-Dipteran Insects (EOG6FQZMV)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\Kap-alpha3   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG019902   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH19516   Atta cephalotes Leafcutter ant  Acep\ACEP26859   Camponotus floridanus Florida carpenter ant  Cflo\CFLO20538   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL15330   Linepithema humile Argentine ant  Lhum\LH24866   Pogonomyrmex barbatus Red harvester ant  Pbar\PB19129   Solenopsis invicta Red fire ant  Sinv\SINV25531   Acyrthosiphon pisum Pea aphid  Apim\ACYPI083997   Acyrthosiphon pisum Pea aphid  Apim\ACYPI005899   Bombyx mori Silkmoth  Bmor\BGIBMGA003758   Pediculus humanus Human body louse  Phum\PHUM584050   Tribolium castaneum Red flour beetle  Tcas\TC014465
Orthologs in non-Insect Arthropods (EOG6M0CGW)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_308902   Ixodes scapularis Deer tick  Isca\ISCW001231
Orthologs in non-Arthropod Metazoa (EOG6GXTF0)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\ima-3 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_019339gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_001309gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_013477gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_018173gn Y Danio rerio Zebrafish  Drer\kpna2 Y Danio rerio Zebrafish  Drer\kpna4 Y Danio rerio Zebrafish  Drer\ENSDARG00000042030 Y Danio rerio Zebrafish  Drer\zgc:55877 Y Danio rerio Zebrafish  Drer\kpna1 Y Danio rerio Zebrafish  Drer\kpna3 Y Danio rerio Zebrafish  Drer\ENSDARG00000044980 Y Xenopus tropicalis Western clawed frog  Xtro\kpna3 Y Xenopus tropicalis Western clawed frog  Xtro\kpna4 Y Xenopus tropicalis Western clawed frog  Xtro\kpna6 Y Xenopus tropicalis Western clawed frog  Xtro\kpna2 Y Xenopus tropicalis Western clawed frog  Xtro\kpna1 Y Xenopus tropicalis Western clawed frog  Xtro\kpna7 Y Gallus gallus Domestic chicken  Ggal\KPNA3 Y Gallus gallus Domestic chicken  Ggal\KPNA7 Y Gallus gallus Domestic chicken  Ggal\KPNA5 Y Gallus gallus Domestic chicken  Ggal\KPNA4 Y Gallus gallus Domestic chicken  Ggal\KPNA6 Y Gallus gallus Domestic chicken  Ggal\KPNA1 Y Gallus gallus Domestic chicken  Ggal\KPNA2 Y Mus musculus House mouse  Mmus\Kpna1 Y Mus musculus House mouse  Mmus\Kpna4 Y Mus musculus House mouse  Mmus\Kpna3 Y Mus musculus House mouse  Mmus\ENSMUSG00000038770 Y Mus musculus House mouse  Mmus\Kpna2 Y Rattus norvegicus Norway rat  Rnor\Kpna3 Y Rattus norvegicus Norway rat  Rnor\Kpna4 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000000127 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000037895 Y Rattus norvegicus Norway rat  Rnor\Kpna7 Y Rattus norvegicus Norway rat  Rnor\Kpna1 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000037940 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000002034 Y Rattus norvegicus Norway rat  Rnor\Kpna5 Y Rattus norvegicus Norway rat  Rnor\Kpna2 Y Homo sapiens Human  Hsap\KPNA2 Y Homo sapiens Human  Hsap\KPNA1 Y Homo sapiens Human  Hsap\KPNA7 Y Homo sapiens Human  Hsap\KPNA6 Y Homo sapiens Human  Hsap\ENSG00000196911 Y Homo sapiens Human  Hsap\KPNA4 Y Homo sapiens Human  Hsap\KPNA3 Y
Human Orthologs (7)
Gene OMIM HGNC Hsap\KPNA2     Hsap\KPNA1     Hsap\KPNA7     Hsap\KPNA6     Hsap\ENSG00000196911     Hsap\KPNA4     Hsap\KPNA3
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD20781 Drosophila sechellia Dsec\GM26241 Drosophila erecta Dere\GG17355 Drosophila yakuba Dyak\GE24760 Drosophila ananassae Dana\GF16531 Drosophila pseudoobscura pseudoobscura Dpse\GA21775 Drosophila persimilis Dper\GL21493 Drosophila willistoni Dwil\GK14517 Drosophila virilis Dvir\GJ10266 Drosophila mojavensis Dmoj\GI23514 Drosophila grimshawi Dgri\GH19298
Stocks & Reagents
Stocks Listed in FlyBase ( 8 )
Bloomington	25395 w*; P{UASp-Kap-α3.M}2 27535 y1 v1; P{TRiP.JF02686}attP2 25397 w*; Kap-α3D93/TM6B, Tb1 15422 y1 w67c23; P{EPgy2}Kap-α3EY02572 30180 w1118; P{EP}Kap-α3G8397/TM6C, Sb1
VDRC	v106249 P{KK101268}VIE-260B v36104 w1118 P{GD14213}v36104 v36103 w1118; P{GD14213}v36103
Genomic Clones ( 1 )
	BACR19N07 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 221 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD13917
Other clones	DPiM_LD13917
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT05411 AT10491 AT18232 GH01702 GH03370 GM01016 GM05410 GM06753 GM19331 GM26178 LD02937 LD03238 LD04778 LD05063 LD05151 LD05490 LD05570 LD05726 LD06116 LD06181 LD07514 LD08602 LD08682 LD08965 LD09426 LD10286 LD10759 LD11342 LD11554 LD13107 LD13788 LD14514 LD14542 LD15251 LD15347 LD15727 LD16068 LD16596 LD16939 LD17005 LD17075 LD17645 LD18158 LD18384 LD19577 LD20175 LD20249 LD20629 LD26454 LD26576 LD27346 LD28425 LD28481 LD28762 LD28784 LD29222 LD29864 LD33544 LD36916 LD38195 LD38353 LD38394 LD38437 LD39861 LD40501 LD41513 LD41609 LD42941 LD44573 LD44786 LD45978 LD47355 LD47409 LP09094 LP19970 RE03729 RE07645 RE10796 RE11435 RE17068 RE17122 RE18844 RE23865 RE25133 RE26561 RE27040 RE29710 RE30028 RE32440 RE33331 RE49781 RE53488 RE54011 RE58290 RE60482 RE61088 RE66318 RE67676 RE67771 RE69443 RE70620 RE74329 RE74702 RH45841 RH55711 RH62335 RH70109 SD01168 SD03806 SD09436 SD16383 SD20852 SD20890 SD21409 SD26759 SD26951
Other clones	bs09e11 Dmel_dig_010397_0590_1367 Dmel_neb_010290_0119_0451 Dmel_neb_013877_0662_0929 Dmel_neb_015187_0672_1361 EC15011 EK009134 EK063562 EK073031 EK105805 EK113528 EK143519 EK166726 EK184456 EK190941 EK220635 EK225618 EK227107 EK254738 EK260506 EK302048 EK306845 EN05616 FGH114B07 FGM301C04 IP16007 IP16107 LD05175 LD06647 LD06663 LD10785 LD14006 LD14520 LD14938 LD19438 LD21491 LD21676 LD29334 LD30405 LD32133 LD34588 LD34752 LD37932 LD38306 LD40305 LD41218 RE01137 RE03130 RE03464 RE04278 RE04648 RE06147 RE07009 RE19564 RE21779 RE33155 RE34454 RE41251 RE41546 RE42108 RE42767 RE44730 RE45228 RE48344 RE48772 RE48981 RE49693 RE50672 RE50881 RE51821 RE61333 RE63042 RE65256 RH21761 RH25738 RH32733 RP003011441 RP003037296 RP003043471 RP003062333 RP003064531 RP003069538 RP003070750 RP003074061 RP003097454 RP003098669 RP003120423 RP003137601 RP003169864 RP003184425 RP003198436 RP003247597 RP003255502 RP003259796 RP003278234 RP003297779 RP003326812 RP003342249 RP003352392 RP003464223 RP003497798 RP003591550 RP003668564
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0027338 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41158
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: karyopherin α3 imp-a3 (FlyBase, 1996-) Source for merge of: karyopherin-α3 karyopherin-α4 (FlyBase, 1996-) Source for merge of: karyopherin-α3 l(3)S033513 (Mathe et al., 2000)
Additional comments	Source for merge of karyopherin α3 imp-a3 was sequence comparison (date:991222). (FlyBase, 1996-) Source for merge of karyopherin-α3 karyopherin-α4 was sequence comparison (date:000103). (FlyBase, 1996-)
Other Comments
	Kap-α3 is required in R7 neurons to mediate a normal preference for UV light. (Ting et al., 2007) RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells. (Boutros et al., 2004) Area matching Drosophila Karyophilin alpha 3 gene, Acc. No. AF152928. (Davies, 2001.3.15) Kap-α3 protein binds specifically to the nuclear localisation sequence of Hsf protein. (Fang et al., 2001)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_169295 NM_169296 NM_176437 NM_001170101 RefSeq (Proteins) • NP_731377 NP_731378 NP_788614 NP_001163572 DDBJ / EMBL / GenBank • AA391399 AA439367 AA567048 AA803000 AA821016 AAC26056 AAD37442 AAF37855 AAF37856 AAF54408 AAK14941 AAL39575 AAN13435 AAO41526 ACZ94869 AF074958 AF152928 AF230871 AF230872 AF230873 AI517850 AI945153 AJ237997 AW942293 AX094224 AY069430 BZ748903 CAB40789 Entrez Gene - A searchable database of RefSeq genes. • 41158 UniProtKB/TrEMBL • O76522 Q9UB78 Q9V455
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Armadillo (IPR000225) Importin-alpha, importin-beta-binding domain (IPR002652) Armadillo-like helical (IPR011989) Armadillo-type fold (IPR016024) Importin subunit alpha (IPR024931) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD13917
Linkouts
	BioGRID - A database of protein and genetic interactions • 66317 DroID - A comprehensive database of gene and protein interactions. • FBgn0027338 DRSC - Results from RNAi screens. • FBgn0027338 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0027338 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9423-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0027338 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41158 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41158 modMine - Data generated by the modENCODE project. • FBgn0027338 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • O76522
Synonyms & Secondary IDs ( 36 )
Reported As
Symbol Synonym	0335/13 (Deak et al., 1997) CG9423 (Liu et al., 2008, Mason et al., 2009, Mason and Goldfarb, 2009, Keleman et al., 2009.8.5, Perkins et al., 2009) dimpα3 (Mamolen et al., 2010) dKap-α3 (Fang et al., 2001) Dα3 (Ratan et al., 2008, Chamaon et al., 2002) imp-a3   imp α3 (Fleming et al., 2005) Imp α-3 (Wong and Baylies, 2004) imp-α3 (Tekotte et al., 2002, Mathe et al., 2000, Ting et al., 2007, Ferguson et al., 2009) IMPα3 (Hogarth et al., 2005) impα3 (Graham et al., 2009, McElroy et al., 2008) Kap-?3 (Tomancak et al., 2007) Kap-alpha3 (Giot et al., 2003, Bartkuhn et al., 2009) KAP-ALPHA3 (Kondo and Perrimon, 2011) Kap α3 (Mason et al., 1999) Kap-α3 (Gwack et al., 2007, Chittaranjan et al., 2009, Chan et al., 2011, Mummery-Widmer et al., 2009, Tokusumi et al., 2012) Kapα3 (McElroy et al., 2008) Kpna3 (Hogarth et al., 2005) l(3)S033513   αKap3 (Phadnis et al., 2012)
Name Synonym	dImportin-α3 (Mamolen et al., 2010) importin a3   importin alpha-3 (Cotterill, 1999.4.1) importin α (Silverman-Gavrila and Wilde, 2006) Importin α-3 (Wong and Baylies, 2005) importin α3 (Mason et al., 2003, Mason et al., 2002, Hogarth et al., 2005, Seong et al., 2010, Sabri et al., 2007, Mason and Goldfarb, 2009) Importin-α3 (Mathe et al., 2000, Ting et al., 2007, Mosca and Schwarz, 2010) importin-α3 (Chan et al., 2007, Graham et al., 2009, Chan et al., 2008, Ferguson et al., 2009) Importin α3 (Mason et al., 2009) karyopherin a3 (Parker et al., 2003, Parker et al., 1999) karyopherin-alpha3 (Boutros et al., 2004) karyopherin-α3 (Leatherman and Jongens, 2003, ) karyopherin α3 (Liu et al., 2008, Mason and Goldfarb, 2009) Karyopherin α3 (Mummery-Widmer et al., 2009) karyopherin α4   karyopherin-α4
Secondary FlyBase IDs
	FBgn0024888 FBgn0026235 FBgn0028164
References ( 72 )
Generate a list of	All references relating to this gene ( 72 )
List References by type	Research paper  ( 30 ) Supplementary material  ( 7 ) Review  ( 3 ) Personal communication to FlyBase  ( 10 ) Abstract  ( 9 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 7 ) Patent  ( 1 ) Stock list  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 4 )
	Phadnis et al., 2012, Mol. Biol. Evol. 29(5): 1429--1440 Birth, death, and replacement of karyopherins in Drosophila. [FBrf0218179] Tokusumi et al., 2012, PLoS ONE 7(7): e41604 Gene regulatory networks controlling hematopoietic progenitor niche cell production and differentiation in the Drosophila lymph gland. [FBrf0219204] Chan et al., 2011, Hum. Mol. Genet. 20(9): 1738--1750 Expanded polyglutamine domain possesses nuclear export activity which modulates subcellular localization and toxicity of polyQ disease protein via exportin-1. [FBrf0214367] Kondo and Perrimon, 2011, Sci. Signal. 4(154): rs1 A Genome-Wide RNAi Screen Identifies Core Components of the G2-M DNA Damage Checkpoint. [FBrf0212700] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...