FB2021_02, released April 13, 2021

Gene: Dmel\fz3

Open Close
General Information
Symbol
Dmel\fz3
Species
D. melanogaster
Name
frizzled 3
Annotation Symbol
CG16785
Feature Type
protein_coding_gene
FlyBase ID
FBgn0027343
Gene Model Status
Current
Stock Availability
11 publicly available
Gene Summary
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Required to coordinate the cytoskeletons of epidermal cells to produce a parallel array of cuticular hairs and bristles. (UniProt, O77438)
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

Dfz3, Dfrizzled-3, EG:34F3.6

Key Links
Genomic Location
Cytogenetic map
1C4-1C4
Sequence location
X:769,945..784,222 [+]
Recombination map
1-0
RefSeq locus
NC_004354 REGION:769945..784222
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (7 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables Wnt-protein binding
inferred from physical interaction with FLYBASE:Wnt2; FB:FBgn0004360
(Wu and Nusse, 2002)
inferred from physical interaction with FLYBASE:wg; FB:FBgn0284084
(Wu and Nusse, 2002)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables nucleic acid binding
inferred from electronic annotation with InterPro:IPR000504
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
enables Wnt-activated receptor activity
inferred from biological aspect of ancestor with PANTHER:PTN000139394
(assigned by GO_Central )
(Gaudet et al., 2011)
enables Wnt-protein binding
inferred from biological aspect of ancestor with PANTHER:PTN000139394
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
involved_in establishment or maintenance of cell polarity
inferred from mutant phenotype
(assigned by UniProt )
(Sato et al., 1999)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in canonical Wnt signaling pathway
inferred from biological aspect of ancestor with PANTHER:PTN000139394
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
located_in integral component of membrane
inferred from sequence or structural similarity
(Brody and Cravchik, 2000)
non-traceable author statement
(assigned by UniProt )
(Sato et al., 1999)
inferred from biological aspect of ancestor with PANTHER:PTN000139394
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN000139394
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the G-protein coupled receptor Fz/Smo family. (O77438)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
FRIZZLED-TYPE RECEPTORS -
The frizzled gene family belong to Class F GPCRs. Frizzled GPCRs are characterized by a large N-terminal extracellular domain containing a cysteine-rich ligand-binding domain. The frizzled genes were first identified in Drosophila. Frizzled proteins are receptors for secreted Wnt proteins, as well as other ligands, and also play a critical role in the regulation of cell polarity. Frizzleds function in three distinct signaling pathways - the planar cell polarity pathway, the canonical Wnt/β-catenin pathway, and the Wnt/calcium pathway. (Adapted from FBrf0222139).
Protein Function (UniProtKB)
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Required to coordinate the cytoskeletons of epidermal cells to produce a parallel array of cuticular hairs and bristles.
(UniProt, O77438)
Summary (Interactive Fly)

transmembrane - 7 pass - frizzled family - antagonizes wingless signal

Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\fz3 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.52

Gene model reviewed during 5.56

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
fz3-RA
FBtr0070138
NM_080296
2249
581
fz3-RB
FBtr0112928
NM_001103389
2304
646
fz3-RC
FBtr0345511
NM_001297831
3250
581
Additional Transcript Data and Comments
Reported size (kB)

2.1 (longest cDNA)

(Sivasankaran et al., 2000)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
fz3-PA
FBpp0070133
63.4
581
8.06
NP_525035
AAF45547
fz3-PB
FBpp0111841
71.4
646
7.86
NP_001096859
ABW09320
fz3-PC
FBpp0311620
63.4
581
8.06
NP_001284760
AHN59231
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

581 aa isoforms: fz3-PA, fz3-PC
Additional Polypeptide Data and Comments
Reported size (kDa)

581 (aa)

(Sivasankaran et al., 2000)
Comments
External Data
Domain

The FZ domain is involved in binding with Wnt ligands.

(UniProt, O77438)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\fz3 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
ventral thoracic disc | restricted
(Sivasankaran et al., 2000)
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 11
ventral ectoderm | segmentally repeated | striped
(Sato et al., 1999)
embryonic stage 11 -- 12
embryonic brain
(Sato et al., 1999)
proventriculus inclusive primordium
(Sato et al., 1999)
anal pad primordium
(Sato et al., 1999)
Malpighian tubule primordium
(Sato et al., 1999)
embryonic stage 12
parasegment 8 of visceral mesoderm
(Sato et al., 1999)
third instar larval stage
wing disc | restricted
(Sivasankaran et al., 2000)
eye-antennal disc | restricted
(Sivasankaran et al., 2000)
early third instar larval stage
ventral thoracic disc | restricted

Comment: within ~6 cell diameters both dorsal and ventral of wg signaling

(Sato et al., 1999)
late third instar larval stage
wing hinge primordium
(Sato et al., 1999)
mesothoracic tergum primordium
(Sato et al., 1999)
wing pouch | faint
(Sato et al., 1999)
photoreceptor cell R7
(Sato et al., 1999)
photoreceptor cell R8
(Sato et al., 1999)
eye disc | restricted

Comment: within several cell diameters of wg expression

(Sato et al., 1999)
antennal disc | restricted
(Sato et al., 1999)
dorsal-ventral compartment boundary of the wing disc
(Sato et al., 1999)
leg disc ventral compartment
(Sato et al., 1999)
Additional Descriptive Data

Expression of fz3 transcript can be first detected at embryonic stage 9.

(Sato et al., 1999)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\fz3 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 10 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of fz3
Transgenic constructs containing regulatory region of fz3
Aberrations (Deficiencies and Duplications) ( 1 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
Sterility
Allele
fertile
Phenotype manifest in
Allele
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (22)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\FZD5
4 of 15
Yes
No
0  
Hsap\FZD9
4 of 15
Yes
Yes
Hsap\FZD10
4 of 15
Yes
Yes
Hsap\FRZB
3 of 15
No
Yes
Hsap\FZD1
3 of 15
No
No
Hsap\FZD3
3 of 15
No
No
Hsap\FZD7
3 of 15
No
No
1  
Hsap\SFRP1
3 of 15
No
Yes
Hsap\SFRP2
3 of 15
No
Yes
Hsap\SFRP4
3 of 15
No
Yes
Hsap\SFRP5
3 of 15
No
Yes
Hsap\FZD2
2 of 15
No
No
Hsap\FZD4
2 of 15
No
No
Hsap\FZD6
2 of 15
No
No
Hsap\FZD8
2 of 15
No
No
Hsap\SMO
2 of 15
No
No
Hsap\CORIN
1 of 15
No
No
Hsap\CPZ
1 of 15
No
No
Hsap\FABP5
1 of 15
No
No
Hsap\MFRP
1 of 15
No
No
Hsap\MIR4683
1 of 15
No
Yes
Hsap\NCOA5
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (20)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Fzd9
4 of 15
Yes
Yes
Mmus\Fzd10
4 of 15
Yes
Yes
Mmus\Frzb
3 of 15
No
Yes
Mmus\Fzd1
3 of 15
No
No
Mmus\Fzd2
3 of 15
No
No
Mmus\Fzd3
3 of 15
No
No
0  
Mmus\Fzd5
3 of 15
No
No
Mmus\Fzd8
3 of 15
No
No
0  
Mmus\Sfrp1
3 of 15
No
Yes
1  
Mmus\Sfrp2
3 of 15
No
Yes
Mmus\Sfrp4
3 of 15
No
Yes
Mmus\Sfrp5
3 of 15
No
Yes
Mmus\Fzd4
2 of 15
No
No
0  
Mmus\Fzd6
2 of 15
No
No
0  
Mmus\Fzd7
2 of 15
No
No
Mmus\Smo
2 of 15
No
No
Mmus\Corin
1 of 15
No
No
Mmus\Cpz
1 of 15
No
No
Mmus\Mfrp
1 of 15
No
No
Mmus\Ncoa5
1 of 15
No
No
Rattus norvegicus (Norway rat) (21)
Rnor\Fzd9
4 of 13
Yes
Yes
Rnor\Fzd1
3 of 13
No
No
0  
Rnor\Fzd2
3 of 13
No
No
0  
Rnor\Fzd3
3 of 13
No
No
Rnor\Fzd7
3 of 13
No
No
Rnor\LOC100909849
3 of 13
No
No
Rnor\Sfrp1
3 of 13
No
Yes
Rnor\Sfrp5
3 of 13
No
Yes
Rnor\Frzb
2 of 13
No
No
Rnor\Fzd4
2 of 13
No
No
Rnor\Fzd5
2 of 13
No
No
Rnor\Fzd6
2 of 13
No
No
Rnor\Fzd8
2 of 13
No
No
Rnor\Sfrp2
2 of 13
No
Yes
Rnor\Sfrp4
2 of 13
No
Yes
Rnor\Smo
2 of 13
No
No
Rnor\Corin
1 of 13
No
No
Rnor\Cpz
1 of 13
No
No
Rnor\Fzd10
1 of 13
No
Yes
Rnor\Mfrp
1 of 13
No
No
Rnor\Ncoa5
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (22)
Xtro\fzd9
4 of 12
Yes
Yes
Xtro\fzd10
4 of 12
Yes
Yes
Xtro\fzd2
3 of 12
No
No
Xtro\fzd3
3 of 12
No
Yes
Xtro\fzd5
3 of 12
No
No
Xtro\fzd7
3 of 12
No
No
Xtro\fzd8
3 of 12
No
No
Xtro\frzb2
2 of 12
No
Yes
Xtro\frzb
2 of 12
No
Yes
Xtro\fzd4
2 of 12
No
No
Xtro\fzd6
2 of 12
No
No
Xtro\sfrp1
2 of 12
No
Yes
Xtro\sfrp2
2 of 12
No
Yes
Xtro\sfrp5
2 of 12
No
Yes
Xtro\sfrpx
2 of 12
No
Yes
Xtro\smo
2 of 12
No
No
Xtro\szl
2 of 12
No
Yes
Xtro\col18a1
1 of 12
No
No
Xtro\corin
1 of 12
No
No
Xtro\cpz
1 of 12
No
No
Xtro\mfrp
1 of 12
No
Yes
Xtro\ncoa5
1 of 12
No
No
Danio rerio (Zebrafish) (29)
Drer\fzd9b
4 of 15
Yes
Yes
Drer\fzd10
4 of 15
Yes
Yes
Drer\frzb
3 of 15
No
Yes
Drer\fzd2
3 of 15
No
No
Drer\fzd3a
3 of 15
No
No
Drer\fzd3b
3 of 15
No
No
Drer\fzd5
3 of 15
No
No
Drer\fzd7a
3 of 15
No
No
Drer\fzd7b
3 of 15
No
No
Drer\fzd8a
3 of 15
No
No
Drer\fzd8b
3 of 15
No
No
Drer\fzd9a
3 of 15
No
Yes
Drer\sfrp1a
3 of 15
No
Yes
Drer\sfrp2
3 of 15
No
Yes
Drer\sfrp5
3 of 15
No
Yes
Drer\szl
3 of 15
No
Yes
Drer\fzd1
2 of 15
No
No
Drer\LOC101884738
2 of 15
No
Yes
Drer\sfrp1b
2 of 15
No
Yes
Drer\sfrp2l
2 of 15
No
Yes
Drer\smo
2 of 15
No
No
Drer\col18a1a
1 of 15
No
No
Drer\corin
1 of 15
No
No
Drer\fzd4
1 of 15
No
No
Drer\fzd6
1 of 15
No
No
Drer\mfrp
1 of 15
No
No
Drer\ncoa5
1 of 15
No
No
Drer\tlc
1 of 15
No
Yes
Drer\wu:fb78f07
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (6)
Cele\cfz-2
2 of 15
Yes
No
Cele\mig-1
2 of 15
Yes
No
Cele\mom-5
2 of 15
Yes
No
Cele\sfrp-1
2 of 15
Yes
Yes
Cele\col-17
1 of 15
No
No
Cele\lin-17
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091906AH )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00004693
Drosophila simulans
Dsim\GD16528
Drosophila sechellia
Dsec\GM19089
Drosophila erecta
Dere\GG12809
Drosophila yakuba
Dyak\GE16636
Drosophila ananassae
Dana\GF21196
Drosophila pseudoobscura pseudoobscura
Dpse\GA14147
Drosophila persimilis
Dper\GL26757
Drosophila willistoni
Dwil\GK20092
Drosophila virilis
Dvir\GJ19053
Drosophila mojavensis
Dmoj\GI11128
Drosophila grimshawi
Dgri\GH17662
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091503E9 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17019192
Glossina morsitans
Tsetse fly
Gmor\GMOY003248
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_02990
Aedes aegypti
Yellow fever mosquito
Aaeg\GPRFZ3
Anopheles darlingi
American malaria mosquito
Adar\ADAC000509
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ018158
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( None identified )
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( None identified )
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
No non-Arthropod Metazoa orthologies identified
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (9)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
fz2
4 of 10
fz4
4 of 10
fz
4 of 10
smo
4 of 10
CG1632
1 of 10
CG14628
1 of 10
CG18823
1 of 10
Corin
1 of 10
Neos
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    FZD5; frizzled class receptor 5
    4 of 15
    601723
         
        FZD9; frizzled class receptor 9
        4 of 15
        601766
            FZD10; frizzled class receptor 10
            4 of 15
            606147
                FRZB; frizzled related protein
                3 of 15
                605083
                  FZD1; frizzled class receptor 1
                  3 of 15
                  603408
                      FZD3; frizzled class receptor 3
                      3 of 15
                      606143
                          FZD7; frizzled class receptor 7
                          3 of 15
                          603410
                               
                              SFRP1; secreted frizzled related protein 1
                              3 of 15
                              604156
                                  SFRP2; secreted frizzled related protein 2
                                  3 of 15
                                  604157
                                      SFRP4; secreted frizzled related protein 4
                                      3 of 15
                                      606570
                                        SFRP5; secreted frizzled related protein 5
                                        3 of 15
                                        604158
                                            Functional Complementation Data
                                            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                                            Interactions
                                            Summary of Physical Interactions
                                            esyN Network Diagram
                                            Show neighbor-neighbor interactions:
                                            Select Layout:
                                            Legend:
                                            Protein
                                            RNA
                                            Selected Interactor(s)
                                            Interactions Browser
                                            View in Interactions Browser
                                            Please see the Physical Interaction reports below for full details
                                            protein-protein
                                            Physical Interaction
                                            Assay
                                            References
                                            fz3 - Wnt2
                                            affinity technology, enzyme linked immunosorbent assay, inferred by author
                                            (Wu and Nusse, 2002)
                                            fz3 - wg
                                            affinity technology, enzyme linked immunosorbent assay, inferred by author
                                            (Wu and Nusse, 2002)
                                            Summary of Genetic Interactions
                                            esyN Network Diagram
                                            esyN Network Key:
                                            Suppression
                                            Enhancement
                                            View in Interactions Browser
                                            Please look at the allele data for full details of the genetic interactions
                                            Starting gene(s)
                                            Interaction type
                                            Interacting gene(s)
                                            Reference
                                            Starting gene(s)
                                            Interaction type
                                            Interacting gene(s)
                                            Reference
                                            ap
                                            suppressible
                                            fz3|wg
                                            (Sato et al., 1999)
                                            Ser
                                            enhanceable
                                            fz3
                                            (Sivasankaran et al., 2000)
                                            wg
                                            suppressible
                                            fz3
                                            (Sato et al., 1999)
                                            External Data
                                            Linkouts
                                            BioGRID - A database of protein and genetic interactions.
                                            DroID - A comprehensive database of gene and protein interactions.
                                            InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                                            MIST (protein-protein) - An integrated Molecular Interaction Database
                                            Pathways
                                            Signaling Pathways (FlyBase)
                                            Metabolic Pathways
                                            External Data
                                            Linkouts
                                            KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
                                            Genomic Location and Detailed Mapping Data
                                            Chromosome (arm)
                                            X
                                            Recombination map
                                            1-0
                                            Cytogenetic map
                                            1C4-1C4
                                            Sequence location
                                            X:769,945..784,222 [+]
                                            FlyBase Computed Cytological Location
                                            Cytogenetic map
                                            Evidence for location
                                            1C4-1C4
                                            Limits computationally determined from genome sequence between P{EP}sdkEP369 and P{EP}EP1600&P{EP}EP1498
                                            Experimentally Determined Cytological Location
                                            Cytogenetic map
                                            Notes
                                            References
                                            1C-1C
                                            (Sivasankaran, 1999.10.15)
                                            1C1-1C1
                                            (Sato et al., 1999)
                                            Experimentally Determined Recombination Data
                                            Location

                                            1-0

                                            (FlyBase, 2016)

                                            1-0.0

                                            (Comeron et al., 2012)
                                            Left of (cM)
                                            Right of (cM)
                                            Notes
                                            Stocks and Reagents
                                            Stocks (11)
                                            Genomic Clones (12)
                                             

                                            Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                                            cDNA Clones (10)
                                             

                                            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                                            cDNA clones, fully sequenced
                                            BDGP DGC clones
                                            Other clones
                                              Drosophila Genomics Resource Center cDNA clones

                                              For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                                              cDNA Clones, End Sequenced (ESTs)
                                              BDGP DGC clones
                                              Other clones
                                              RNAi and Array Information
                                              Linkouts
                                              DRSC - Results frm RNAi screens
                                              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                                              Antibody Information
                                              Laboratory Generated Antibodies
                                               
                                              Commercially Available Antibodies
                                               
                                              Other Information
                                              Relationship to Other Genes
                                              Source for database identify of

                                              Source for identity of: fz3 CG16785

                                              (Lai, 1999.11)
                                              Source for database merge of

                                              Source for merge of: fz3 EG:34F3.6

                                              (FlyBase, 1996-)
                                              Additional comments

                                              Source for merge of fz3 EG:34F3.6 was sequence comparison ( date:000202 ).

                                              (FlyBase, 1996-)
                                              Other Comments

                                              Molecular null mutants are perfectly viable and show no phenotype.

                                              (Sivasankaran et al., 2000)

                                              fz3 expression is positively regulated by wg signaling. Overall orientation not stated: anon-1Ca- fz3+

                                              (Sato et al., 1999)

                                              fz3 may serve as an attenuator of wg signaling.

                                              (Sato et al., 1999)
                                              Origin and Etymology
                                              Discoverer
                                              Etymology
                                              Identification
                                              External Crossreferences and Linkouts ( 55 )
                                              Sequence Crossreferences
                                              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                                              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                              UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                                              UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                                              Other crossreferences
                                              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                                              Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                                              Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                                              Flygut - An atlas of the Drosophila adult midgut
                                              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                                              InterPro - A database of protein families, domains and functional sites
                                              KEGG Genes - Molecular building blocks of life in the genomic space.
                                              modMine - A data warehouse for the modENCODE project
                                              SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                                              Linkouts
                                              BioGRID - A database of protein and genetic interactions.
                                              DroID - A comprehensive database of gene and protein interactions.
                                              DRSC - Results frm RNAi screens
                                              FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                                              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                                              FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                                              FlyMine - An integrated database for Drosophila genomics
                                              Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                                              InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                                              KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
                                              MIST (protein-protein) - An integrated Molecular Interaction Database
                                              Synonyms and Secondary IDs (14)
                                              Reported As
                                              Symbol Synonym
                                              CG16785
                                              (Schertel et al., 2013, Chen et al., 2012, Hadar et al., 2012, Zhang et al., 2011, Ni et al., 2010.12.1, Zhang et al., 2010, Perkins et al., 2009, Khokhar et al., 2008, Quinones-Coello, 2007, Benos, 2000.12.13)
                                              DFz3
                                              (Mosimann et al., 2006, Schweizer and Varmus, 2003, Wu and Nusse, 2002)
                                              Dfz3
                                              (Klebes et al., 2005, Chen et al., 2004, Huang and Klein, 2004, Jones, 2000, Sato et al., 2000, Sivasankaran et al., 2000, Sato et al., 1999)
                                              Dm Fz3
                                              (Konikoff et al., 2010)
                                              EG:34F3.6
                                              (Benos et al., 2001, Benos, 2000.12.13)
                                              Fz3
                                              (Kizhedathu et al., 2020, Melamed and Kalderon, 2020, Johansson et al., 2019, Martins et al., 2017, Alexandre et al., 2014, Pancratov et al., 2013, Regnard et al., 2011)
                                              dFz3
                                              (Kennell and Cadigan, 2008)
                                              dfz3
                                              (Mohan et al., 2010, Taniue et al., 2010, Li et al., 2004)
                                              fz3
                                              (Ewen-Campen et al., 2020, Mo et al., 2020, Waghmare et al., 2020, Meltzer et al., 2019, Tian et al., 2019, Tsai and Galko, 2019, Franz et al., 2017, Tian et al., 2017, Jenny and Basler, 2016, Sarov et al., 2016, Tian et al., 2016, Hall and Verheyen, 2015, Menuz et al., 2014, Schilling et al., 2014, Schertel et al., 2013, Shen et al., 2013, Southall et al., 2013, Wang et al., 2013, Hadar et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Legent et al., 2012, Cherbas et al., 2011, Olson et al., 2011, Toku et al., 2011, Piddini and Vincent, 2009, Song et al., 2009, Chang et al., 2008, Kennell et al., 2008, Khokhar et al., 2008, Quinones-Coello, 2007, Zeitlinger et al., 2007, Srahna et al., 2006, Pickeral et al., 2000)
                                              Name Synonyms
                                              Dfrizzled-3
                                              (Adachi-Yamada and O'Connor, 2002, Sato et al., 1999, Saigo, 1998.10.12)
                                              Frizzled 3
                                              (Niehrs, 2012, Davis et al., 2011)
                                              dFrizzled3
                                              (Valenta et al., 2011)
                                              frizzled 3
                                              (Tian et al., 2016, Dunne et al., 2014, Mohan et al., 2010, Song et al., 2009, Khokhar et al., 2008, Sato et al., 1999)
                                              frizzled3
                                              (Waghmare and Page-McCaw, 2018, Davis et al., 2011, Olson et al., 2011)
                                              Secondary FlyBase IDs
                                              • FBgn0025619
                                              Datasets (0)
                                              Study focus (0)
                                              Experimental Role
                                              Project
                                              Project Type
                                              Title
                                              References (113)