A Database of Drosophila Genes & Genomes

FB2012_01, released January 20th, 2012
 

Gene Dmel\Tim8

General Information
SymbolDmel\Tim8SpeciesD. melanogaster
NameTim8Annotation symbolCG1728
Feature typeprotein_coding_geneFlyBase IDFBgn0027359
Gene Model StatusCurrent Stock availability 6 publicly available
Genomic Location
Chromosome (arm)XRecombination map
Cytogenetic map10B6-10B6Sequence locationX:11,262,464..11,263,216 [+]

Genomic Maps

GBrowse View Help
modENCODE GBrowse
detailed view
hide Summary Information
Automatically generated summary

See sections below for more information
The gene Tim8 is referred to in FlyBase by the symbol Dmel\Tim8 (CG1728, FBgn0027359). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: P-P-bond-hydrolysis-driven protein transmembrane transporter activity. Based on sequence similarity, it is predicted to be involved in the biological process: protein targeting to mitochondrion; protein transport. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Mitochondrial inner membrane translocase complex, Tim8/9/10/13-zinc finger-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed during early larval stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult central nervous system, larval fat body, larval/adult salivary gland, larval trachea, adult ovary, adult testis. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, adult fat body, adult spermathecae, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1637967_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Tim8. Gene sequence location is X:11262464..11263216.
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Description
What does this section display?
This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).
What does this section not display?
This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01
Sequence features
All updates Click here to see a list of all updates to this record from FB2010_08 and on.
hide Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
10B6-10B6  
Limits computationally determined from genome sequence between P{EP}CG11756EP1610 and P{EP}CG32666EP1452  
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
hide Gene Model & Products
Please see the GBrowse view of Dmel\Tim8 for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
detailed view FBtr0073457 FBtr0073482 FBtr0073490 FBtr0112813 FBtr0073491 FBtr0073488 FBtr0073492 FBtr0073483 FBpp0073313 FBpp0073338 FBti0071723 FBti0024932 FBti0052587 FBti0068320
Comments on Gene Model
Gene model reviewed during 5.40
hide Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Associated CDS (aa)
FBtr0073482
  675
  88
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
hide Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
FBpp0073338  
10.1  
88  
4.80  
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins
  • MTDROME01728
hide Sequences Consistent with the Gene Model
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
hide Mapped Features
Mapped Features have been reorganized, please see this article for details.
Additional mapped features and mutations can be found on GBrowse or related reports.
Type
Symbol & Location
Additional Notes
References
hide External Data
Linkouts
Crossreferences
hide Expression Data
hideTranscript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
hidePolypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
hide High-Throughput Expression Data
or
Untitled Document detailed view hop-RA Tim8-RA dlg1-RH dlg1-RL dlg1-RI dlg1-RB dlg1-RJ dlg1-RC
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.

modENCODE Temporal Expression Data for FBgn0027359


   Styles
Linear
Logarithmic
Heatmap
   Scales
max expr for FBgn0027359
Very low expression bin max
Moderate expression bin max
High expression bin max
Extremely high expression bin max

Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed during early larval stages.
[download data (TSV)]

Guide to modENCODE expression level colors
 
No expression (0 - 0)
 
Extremely low expression (1 - 10)
 
Very low expression (11 - 100)
 
Low expression (101 - 400)
 
Moderate expression (401 - 1400)
 
Moderately high expression (1401 - 4000)
 
High expression (4001 - 10000)
 
Very high expression (10001 - 100000)
 
Extremely high expression (100001 - 2000000)

Linear, scaled to maximum FBgn0027359 expression level
Developmental Stage   Expression Level
embryo 00-02hr
 
 8506
embryo 02-04hr
 
 2201
embryo 04-06hr
 
 3831
embryo 06-08hr
 
 4043
embryo 08-10hr
 
 5121
embryo 10-12hr
 
 6722
embryo 12-14hr
 
 5781
embryo 14-16hr
 
 6491
embryo 16-18hr
 
 7254
embryo 18-20hr
 
 5552
embryo 20-22hr
 
 5190
embryo 22-24hr
 
 4765
larva L1
 
 10923
larva L2
 
 10488
larva L3 12hr old
 
 7020
larva L3 puffstage 1-2
 
 2994
larva L3 puffstage 3-6
 
 2986
larva L3 puffstage 7-9
 
 3560
white prepupae new
 
 3316
white prepupae 12hr
 
 2731
white prepupae 24hr
 
 3932
pupae 2d postWPP
 
 5747
pupae 3d postWPP
 
 6428
pupae 4d postWPP
 
 5004
adult male 01day
 
 5717
adult male 05day
 
 6544
adult male 30day
 
 5911
adult female 01day
 
 6002
adult female 05day
 
 7446
adult female 30day
 
 7946
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
Linear, scaled to Very low expression
Developmental Stage   Expression Level
embryo 00-02hr
 (8506)
embryo 02-04hr
 (2201)
embryo 04-06hr
 (3831)
embryo 06-08hr
 (4043)
embryo 08-10hr
 (5121)
embryo 10-12hr
 (6722)
embryo 12-14hr
 (5781)
embryo 14-16hr
 (6491)
embryo 16-18hr
 (7254)
embryo 18-20hr
 (5552)
embryo 20-22hr
 (5190)
embryo 22-24hr
 (4765)
larva L1
 (10923)
larva L2
 (10488)
larva L3 12hr old
 (7020)
larva L3 puffstage 1-2
 (2994)
larva L3 puffstage 3-6
 (2986)
larva L3 puffstage 7-9
 (3560)
white prepupae new
 (3316)
white prepupae 12hr
 (2731)
white prepupae 24hr
 (3932)
pupae 2d postWPP
 (5747)
pupae 3d postWPP
 (6428)
pupae 4d postWPP
 (5004)
adult male 01day
 (5717)
adult male 05day
 (6544)
adult male 30day
 (5911)
adult female 01day
 (6002)
adult female 05day
 (7446)
adult female 30day
 (7946)
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
Linear, scaled to Moderate expression
Developmental Stage   Expression Level
embryo 00-02hr
 (8506)
embryo 02-04hr
 (2201)
embryo 04-06hr
 (3831)
embryo 06-08hr
 (4043)
embryo 08-10hr
 (5121)
embryo 10-12hr
 (6722)
embryo 12-14hr
 (5781)
embryo 14-16hr
 (6491)
embryo 16-18hr
 (7254)
embryo 18-20hr
 (5552)
embryo 20-22hr
 (5190)
embryo 22-24hr
 (4765)
larva L1
 (10923)
larva L2
 (10488)
larva L3 12hr old
 (7020)
larva L3 puffstage 1-2
 (2994)
larva L3 puffstage 3-6
 (2986)
larva L3 puffstage 7-9
 (3560)
white prepupae new
 (3316)
white prepupae 12hr
 (2731)
white prepupae 24hr
 (3932)
pupae 2d postWPP
 (5747)
pupae 3d postWPP
 (6428)
pupae 4d postWPP
 (5004)
adult male 01day
 (5717)
adult male 05day
 (6544)
adult male 30day
 (5911)
adult female 01day
 (6002)
adult female 05day
 (7446)
adult female 30day
 (7946)
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
Linear, scaled to High expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 8506
embryo 02-04hr
 
 2201
embryo 04-06hr
 
 3831
embryo 06-08hr
 
 4043
embryo 08-10hr
 
 5121
embryo 10-12hr
 
 6722
embryo 12-14hr
 
 5781
embryo 14-16hr
 
 6491
embryo 16-18hr
 
 7254
embryo 18-20hr
 
 5552
embryo 20-22hr
 
 5190
embryo 22-24hr
 
 4765
larva L1
 (10923)
larva L2
 10488
larva L3 12hr old
 
 7020
larva L3 puffstage 1-2
 
 2994
larva L3 puffstage 3-6
 
 2986
larva L3 puffstage 7-9
 
 3560
white prepupae new
 
 3316
white prepupae 12hr
 
 2731
white prepupae 24hr
 
 3932
pupae 2d postWPP
 
 5747
pupae 3d postWPP
 
 6428
pupae 4d postWPP
 
 5004
adult male 01day
 
 5717
adult male 05day
 
 6544
adult male 30day
 
 5911
adult female 01day
 
 6002
adult female 05day
 
 7446
adult female 30day
 
 7946
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
Linear, scaled to Extremely high expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 8506
embryo 02-04hr
 
 2201
embryo 04-06hr
 
 3831
embryo 06-08hr
 
 4043
embryo 08-10hr
 
 5121
embryo 10-12hr
 
 6722
embryo 12-14hr
 
 5781
embryo 14-16hr
 
 6491
embryo 16-18hr
 
 7254
embryo 18-20hr
 
 5552
embryo 20-22hr
 
 5190
embryo 22-24hr
 
 4765
larva L1
 
 10923
larva L2
 
 10488
larva L3 12hr old
 
 7020
larva L3 puffstage 1-2
 
 2994
larva L3 puffstage 3-6
 
 2986
larva L3 puffstage 7-9
 
 3560
white prepupae new
 
 3316
white prepupae 12hr
 
 2731
white prepupae 24hr
 
 3932
pupae 2d postWPP
 
 5747
pupae 3d postWPP
 
 6428
pupae 4d postWPP
 
 5004
adult male 01day
 
 5717
adult male 05day
 
 6544
adult male 30day
 
 5911
adult female 01day
 
 6002
adult female 05day
 
 7446
adult female 30day
 
 7946
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
 Extremely high 
log, scaled to maximum FBgn0027359 expression level
Developmental Stage   Expression Level
embryo 00-02hr
 
 8506
embryo 02-04hr
 
 2201
embryo 04-06hr
 
 3831
embryo 06-08hr
 
 4043
embryo 08-10hr
 
 5121
embryo 10-12hr
 
 6722
embryo 12-14hr
 
 5781
embryo 14-16hr
 
 6491
embryo 16-18hr
 
 7254
embryo 18-20hr
 
 5552
embryo 20-22hr
 
 5190
embryo 22-24hr
 
 4765
larva L1
 
 10923
larva L2
 
 10488
larva L3 12hr old
 
 7020
larva L3 puffstage 1-2
 
 2994
larva L3 puffstage 3-6
 
 2986
larva L3 puffstage 7-9
 
 3560
white prepupae new
 
 3316
white prepupae 12hr
 
 2731
white prepupae 24hr
 
 3932
pupae 2d postWPP
 
 5747
pupae 3d postWPP
 
 6428
pupae 4d postWPP
 
 5004
adult male 01day
 
 5717
adult male 05day
 
 6544
adult male 30day
 
 5911
adult female 01day
 
 6002
adult female 05day
 
 7446
adult female 30day
 
 7946
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
log, scaled to Very low expression
Developmental Stage   Expression Level
embryo 00-02hr
 (8506)
embryo 02-04hr
 (2201)
embryo 04-06hr
 (3831)
embryo 06-08hr
 (4043)
embryo 08-10hr
 (5121)
embryo 10-12hr
 (6722)
embryo 12-14hr
 (5781)
embryo 14-16hr
 (6491)
embryo 16-18hr
 (7254)
embryo 18-20hr
 (5552)
embryo 20-22hr
 (5190)
embryo 22-24hr
 (4765)
larva L1
 (10923)
larva L2
 (10488)
larva L3 12hr old
 (7020)
larva L3 puffstage 1-2
 (2994)
larva L3 puffstage 3-6
 (2986)
larva L3 puffstage 7-9
 (3560)
white prepupae new
 (3316)
white prepupae 12hr
 (2731)
white prepupae 24hr
 (3932)
pupae 2d postWPP
 (5747)
pupae 3d postWPP
 (6428)
pupae 4d postWPP
 (5004)
adult male 01day
 (5717)
adult male 05day
 (6544)
adult male 30day
 (5911)
adult female 01day
 (6002)
adult female 05day
 (7446)
adult female 30day
 (7946)
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
log, scaled to Moderate expression
Developmental Stage   Expression Level
embryo 00-02hr
 (8506)
embryo 02-04hr
 2201
embryo 04-06hr
 (3831)
embryo 06-08hr
 (4043)
embryo 08-10hr
 (5121)
embryo 10-12hr
 (6722)
embryo 12-14hr
 (5781)
embryo 14-16hr
 (6491)
embryo 16-18hr
 (7254)
embryo 18-20hr
 (5552)
embryo 20-22hr
 (5190)
embryo 22-24hr
 (4765)
larva L1
 (10923)
larva L2
 (10488)
larva L3 12hr old
 (7020)
larva L3 puffstage 1-2
 (2994)
larva L3 puffstage 3-6
 (2986)
larva L3 puffstage 7-9
 (3560)
white prepupae new
 (3316)
white prepupae 12hr
 (2731)
white prepupae 24hr
 (3932)
pupae 2d postWPP
 (5747)
pupae 3d postWPP
 (6428)
pupae 4d postWPP
 (5004)
adult male 01day
 (5717)
adult male 05day
 (6544)
adult male 30day
 (5911)
adult female 01day
 (6002)
adult female 05day
 (7446)
adult female 30day
 (7946)
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
log, scaled to High expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 8506
embryo 02-04hr
 
 2201
embryo 04-06hr
 
 3831
embryo 06-08hr
 
 4043
embryo 08-10hr
 
 5121
embryo 10-12hr
 
 6722
embryo 12-14hr
 
 5781
embryo 14-16hr
 
 6491
embryo 16-18hr
 
 7254
embryo 18-20hr
 
 5552
embryo 20-22hr
 
 5190
embryo 22-24hr
 
 4765
larva L1
 10923
larva L2
 10488
larva L3 12hr old
 
 7020
larva L3 puffstage 1-2
 
 2994
larva L3 puffstage 3-6
 
 2986
larva L3 puffstage 7-9
 
 3560
white prepupae new
 
 3316
white prepupae 12hr
 
 2731
white prepupae 24hr
 
 3932
pupae 2d postWPP
 
 5747
pupae 3d postWPP
 
 6428
pupae 4d postWPP
 
 5004
adult male 01day
 
 5717
adult male 05day
 
 6544
adult male 30day
 
 5911
adult female 01day
 
 6002
adult female 05day
 
 7446
adult female 30day
 
 7946
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
log, scaled to Extremely high expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 8506
embryo 02-04hr
 
 2201
embryo 04-06hr
 
 3831
embryo 06-08hr
 
 4043
embryo 08-10hr
 
 5121
embryo 10-12hr
 
 6722
embryo 12-14hr
 
 5781
embryo 14-16hr
 
 6491
embryo 16-18hr
 
 7254
embryo 18-20hr
 
 5552
embryo 20-22hr
 
 5190
embryo 22-24hr
 
 4765
larva L1
 
 10923
larva L2
 
 10488
larva L3 12hr old
 
 7020
larva L3 puffstage 1-2
 
 2994
larva L3 puffstage 3-6
 
 2986
larva L3 puffstage 7-9
 
 3560
white prepupae new
 
 3316
white prepupae 12hr
 
 2731
white prepupae 24hr
 
 3932
pupae 2d postWPP
 
 5747
pupae 3d postWPP
 
 6428
pupae 4d postWPP
 
 5004
adult male 01day
 
 5717
adult male 05day
 
 6544
adult male 30day
 
 5911
adult female 01day
 
 6002
adult female 05day
 
 7446
adult female 30day
 
 7946
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
 Extremely high 
Heatmap
Developmental Stage   Expression Level
embryo 00-02hr
 
 
embryo 02-04hr
 
 
embryo 04-06hr
 
 
embryo 06-08hr
 
 
embryo 08-10hr
 
 
embryo 10-12hr
 
 
embryo 12-14hr
 
 
embryo 14-16hr
 
 
embryo 16-18hr
 
 
embryo 18-20hr
 
 
embryo 20-22hr
 
 
embryo 22-24hr
 
 
larva L1
 
 
larva L2
 
 
larva L3 12hr old
 
 
larva L3 puffstage 1-2
 
 
larva L3 puffstage 3-6
 
 
larva L3 puffstage 7-9
 
 
white prepupae new
 
 
white prepupae 12hr
 
 
white prepupae 24hr
 
 
pupae 2d postWPP
 
 
pupae 3d postWPP
 
 
pupae 4d postWPP
 
 
adult male 01day
 
 
adult male 05day
 
 
adult male 30day
 
 
adult female 01day
 
 
adult female 05day
 
 
adult female 30day
 
 

FlyAtlas Anatomical Expression Data for FBgn0027359


   Styles
Linear
Logarithmic
Heatmap
Back-to-back
   Scales
max expr for FBgn0027359
Moderate expression bin max
High level expression bin max
Very high expression bin max

Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult central nervous system, larval fat body, larval/adult salivary gland, larval trachea, adult ovary, adult testis. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, adult fat body, adult spermathecae, adult male accessory gland, larval/adult carcass.
[download data (TSV)]

Guide to FlyAtlas expression level colors
 
No expression (0 - 9.999)
 
Low expression (10 - 99.999)
 
Moderate expression (100 - 499.999)
 
High level expression (500 - 999.999)
 
Very high expression (1000 - 25000)

Linear, scaled to maximum FBgn0027359 expression level
Tissue   Expression Level
Larval Central Nervous System
 
 488.9
Larval Midgut
 
 291.2
Larval Hindgut
 
 390.4
Larval Malpighian Tubules
 
 192.3
Larval Fat Body
 
 742.2
Larval Salivary Gland
 
 771.9
Larval Trachea
 
 685.5
Larval Carcass
 
 337.575
Adult Head
 
 423.7
Adult Eye
 
 341.675
Adult Brain
 
 566.5
Adult Thoracic-Abdominal Ganglion
 
 571.6
Adult Crop
 
 265.4
Adult Midgut
 
 404.9
Adult Hindgut
 
 332.5
Adult Malpighian Tubules
 
 307.5
Adult Fat Body
 
 451.5
Adult Salivary Gland
 
 507
Adult Heart
 
 348.775
Adult VirginFemale Spermatheca
 
 280.7
Adult InseminatedFemale Spermatheca
 
 312.3
Adult Ovary
 
 776.2
Adult Testis
 
 646.8
Adult Male Accessory Gland
 
 448.9
Adult Carcass
 
 415.9
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
Linear, scaled to Moderate expression
Tissue   Expression Level
Larval Central Nervous System
 
 488.9
Larval Midgut
 
 291.2
Larval Hindgut
 
 390.4
Larval Malpighian Tubules
 
 192.3
Larval Fat Body
 (742.2)
Larval Salivary Gland
 (771.9)
Larval Trachea
 (685.5)
Larval Carcass
 
 337.575
Adult Head
 
 423.7
Adult Eye
 
 341.675
Adult Brain
 (566.5)
Adult Thoracic-Abdominal Ganglion
 (571.6)
Adult Crop
 
 265.4
Adult Midgut
 
 404.9
Adult Hindgut
 
 332.5
Adult Malpighian Tubules
 
 307.5
Adult Fat Body
 
 451.5
Adult Salivary Gland
 507
Adult Heart
 
 348.775
Adult VirginFemale Spermatheca
 
 280.7
Adult InseminatedFemale Spermatheca
 
 312.3
Adult Ovary
 (776.2)
Adult Testis
 (646.8)
Adult Male Accessory Gland
 
 448.9
Adult Carcass
 
 415.9
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
Linear, scaled to High level expression
Tissue   Expression Level
Larval Central Nervous System
 
 488.9
Larval Midgut
 
 291.2
Larval Hindgut
 
 390.4
Larval Malpighian Tubules
 
 192.3
Larval Fat Body
 
 742.2
Larval Salivary Gland
 
 771.9
Larval Trachea
 
 685.5
Larval Carcass
 
 337.575
Adult Head
 
 423.7
Adult Eye
 
 341.675
Adult Brain
 
 566.5
Adult Thoracic-Abdominal Ganglion
 
 571.6
Adult Crop
 
 265.4
Adult Midgut
 
 404.9
Adult Hindgut
 
 332.5
Adult Malpighian Tubules
 
 307.5
Adult Fat Body
 
 451.5
Adult Salivary Gland
 
 507
Adult Heart
 
 348.775
Adult VirginFemale Spermatheca
 
 280.7
Adult InseminatedFemale Spermatheca
 
 312.3
Adult Ovary
 
 776.2
Adult Testis
 
 646.8
Adult Male Accessory Gland
 
 448.9
Adult Carcass
 
 415.9
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
Linear, scaled to Very high expression
Tissue   Expression Level
Larval Central Nervous System
 
 488.9
Larval Midgut
 
 291.2
Larval Hindgut
 
 390.4
Larval Malpighian Tubules
 
 192.3
Larval Fat Body
 
 742.2
Larval Salivary Gland
 
 771.9
Larval Trachea
 
 685.5
Larval Carcass
 
 337.575
Adult Head
 
 423.7
Adult Eye
 
 341.675
Adult Brain
 
 566.5
Adult Thoracic-Abdominal Ganglion
 
 571.6
Adult Crop
 
 265.4
Adult Midgut
 
 404.9
Adult Hindgut
 
 332.5
Adult Malpighian Tubules
 
 307.5
Adult Fat Body
 
 451.5
Adult Salivary Gland
 
 507
Adult Heart
 
 348.775
Adult VirginFemale Spermatheca
 
 280.7
Adult InseminatedFemale Spermatheca
 
 312.3
Adult Ovary
 
 776.2
Adult Testis
 
 646.8
Adult Male Accessory Gland
 
 448.9
Adult Carcass
 
 415.9
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
log, scaled to maximum FBgn0027359 expression level
Tissue   Expression Level
Larval Central Nervous System
 
 488.9
Larval Midgut
 
 291.2
Larval Hindgut
 
 390.4
Larval Malpighian Tubules
 
 192.3
Larval Fat Body
 
 742.2
Larval Salivary Gland
 
 771.9
Larval Trachea
 
 685.5
Larval Carcass
 
 337.575
Adult Head
 
 423.7
Adult Eye
 
 341.675
Adult Brain
 
 566.5
Adult Thoracic-Abdominal Ganglion
 
 571.6
Adult Crop
 
 265.4
Adult Midgut
 
 404.9
Adult Hindgut
 
 332.5
Adult Malpighian Tubules
 
 307.5
Adult Fat Body
 
 451.5
Adult Salivary Gland
 
 507
Adult Heart
 
 348.775
Adult VirginFemale Spermatheca
 
 280.7
Adult InseminatedFemale Spermatheca
 
 312.3
Adult Ovary
 
 776.2
Adult Testis
 
 646.8
Adult Male Accessory Gland
 
 448.9
Adult Carcass
 
 415.9
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
log, scaled to Moderate expression
Tissue   Expression Level
Larval Central Nervous System
 
 488.9
Larval Midgut
 
 291.2
Larval Hindgut
 
 390.4
Larval Malpighian Tubules
 
 192.3
Larval Fat Body
 742.2
Larval Salivary Gland
 771.9
Larval Trachea
 685.5
Larval Carcass
 
 337.575
Adult Head
 
 423.7
Adult Eye
 
 341.675
Adult Brain
 566.5
Adult Thoracic-Abdominal Ganglion
 571.6
Adult Crop
 
 265.4
Adult Midgut
 
 404.9
Adult Hindgut
 
 332.5
Adult Malpighian Tubules
 
 307.5
Adult Fat Body
 
 451.5
Adult Salivary Gland
 507
Adult Heart
 
 348.775
Adult VirginFemale Spermatheca
 
 280.7
Adult InseminatedFemale Spermatheca
 
 312.3
Adult Ovary
 776.2
Adult Testis
 646.8
Adult Male Accessory Gland
 
 448.9
Adult Carcass
 
 415.9
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
log, scaled to High level expression
Tissue   Expression Level
Larval Central Nervous System
 
 488.9
Larval Midgut
 
 291.2
Larval Hindgut
 
 390.4
Larval Malpighian Tubules
 
 192.3
Larval Fat Body
 
 742.2
Larval Salivary Gland
 
 771.9
Larval Trachea
 
 685.5
Larval Carcass
 
 337.575
Adult Head
 
 423.7
Adult Eye
 
 341.675
Adult Brain
 
 566.5
Adult Thoracic-Abdominal Ganglion
 
 571.6
Adult Crop
 
 265.4
Adult Midgut
 
 404.9
Adult Hindgut
 
 332.5
Adult Malpighian Tubules
 
 307.5
Adult Fat Body
 
 451.5
Adult Salivary Gland
 
 507
Adult Heart
 
 348.775
Adult VirginFemale Spermatheca
 
 280.7
Adult InseminatedFemale Spermatheca
 
 312.3
Adult Ovary
 
 776.2
Adult Testis
 
 646.8
Adult Male Accessory Gland
 
 448.9
Adult Carcass
 
 415.9
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
log, scaled to Very high expression
Tissue   Expression Level
Larval Central Nervous System
 
 488.9
Larval Midgut
 
 291.2
Larval Hindgut
 
 390.4
Larval Malpighian Tubules
 
 192.3
Larval Fat Body
 
 742.2
Larval Salivary Gland
 
 771.9
Larval Trachea
 
 685.5
Larval Carcass
 
 337.575
Adult Head
 
 423.7
Adult Eye
 
 341.675
Adult Brain
 
 566.5
Adult Thoracic-Abdominal Ganglion
 
 571.6
Adult Crop
 
 265.4
Adult Midgut
 
 404.9
Adult Hindgut
 
 332.5
Adult Malpighian Tubules
 
 307.5
Adult Fat Body
 
 451.5
Adult Salivary Gland
 
 507
Adult Heart
 
 348.775
Adult VirginFemale Spermatheca
 
 280.7
Adult InseminatedFemale Spermatheca
 
 312.3
Adult Ovary
 
 776.2
Adult Testis
 
 646.8
Adult Male Accessory Gland
 
 448.9
Adult Carcass
 
 415.9
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
Heatmap
Tissue   Expression Level
Larval Central Nervous System
 
 
Larval Midgut
 
 
Larval Hindgut
 
 
Larval Malpighian Tubules
 
 
Larval Fat Body
 
 
Larval Salivary Gland
 
 
Larval Trachea
 
 
Larval Carcass
 
 
Adult Head
 
 
Adult Eye
 
 
Adult Brain
 
 
Adult Thoracic-Abdominal Ganglion
 
 
Adult Crop
 
 
Adult Midgut
 
 
Adult Hindgut
 
 
Adult Malpighian Tubules
 
 
Adult Fat Body
 
 
Adult Salivary Gland
 
 
Adult Heart
 
 
Adult VirginFemale Spermatheca
 
 
Adult InseminatedFemale Spermatheca
 
 
Adult Ovary
 
 
Adult Testis
 
 
Adult Male Accessory Gland
 
 
Adult Carcass
 
 

FlyAtlas Organ/Tissue Expression, larval vs. adult
Larval Expression Level Tissue Adult Expression Level
 
NA 
Head
 
 423.7
 
NA 
Eye
 
 341.675
 
NA 
Brain
 
 566.5
 
488.9 
Central Nervous System
 
 NA
 
NA 
Thoracic-Abdominal Ganglion
 
 571.6
 
NA 
Crop
 
 265.4
 
291.2 
Midgut
 
 404.9
 
390.4 
Hindgut
 
 332.5
 
192.3 
Malpighian Tubules
 
 307.5
 
742.2 
Fat Body
 
 451.5
 
771.9 
Salivary Gland
 
 507
 
NA 
Heart
 
 348.775
 
685.5 
Trachea
 
 NA
 
NA 
VirginFemale Spermatheca
 
 280.7
 
NA 
InseminatedFemale Spermatheca
 
 312.3
 
NA 
Ovary
 
 776.2
 
NA 
Testis
 
 646.8
 
NA 
Male Accessory Gland
 
 448.9
 
337.575 
Carcass
 
 415.9

modENCODE Temporal Expression Data (Graveley et al., 2011)
FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
hide Expression Clusters
A cluster of genes with similar mRNA expression dynamics across development.
hide External Data & Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
hide Alleles & Phenotypes
hide Summary of Allele Phenotypes
Lethality
Allele
Phenotype manifest in
Allele
hide Classical Alleles ( 0 )
For All Classical Alleles Show

Allele of Tim8ClassMutagenStocksKnown lesion
hide Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show

Allele of Tim8ClassMutagenStocksKnown lesion
Tim8GD136334 Yes
Tim8JF015331 Yes
Tim8KK1085301 Yes
hide Aneuploid Aberrations
hide Transgenic Constructs & Insertions
Transgenic Constructs
Type of construct
Name
Expression data
Insertions
Type of insertions
Name
Expression data
hide Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
hide Terms Based on Experimental Evidence ( 0 terms )
hide Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term
References
inferred from sequence or structural similarity
inferred from sequence or structural similarity with UniProtKB:O60220 AND inferred from sequence or structural similarity with UniProt:Q9Y5J9
Biological Process
CV term
References
inferred from sequence or structural similarity with UniProtKB:O60220 AND inferred from sequence or structural similarity with UniProt:Q9Y5J9
inferred from sequence or structural similarity
Cellular Component
CV term
References
inferred from sequence or structural similarity
inferred from sequence or structural similarity with UniProtKB:O60220 AND inferred from sequence or structural similarity with UniProt:Q9Y5J9
non-traceable author statement
hide Sequence Ontology: Class of Gene
hide Interactions & Pathways
hide Summary of Physical Interactions
Protein-protein
Interacting group
Assay
References
hide Summary of Genetic Interactions
Interacts with
Please look at the allele data for full details of the genetic interactions
Tim8 allele
Gene
References
hide External Data
Linkouts
BioGRID - A database of protein and genetic interactions
DPiM - DPiM, Drosophila Protein interaction Map
DroID - A comprehensive database of gene and protein interactions.
InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.
hide Orthologs
Genome-wide drosophilid orthologs
Curated drosophilid orthologs
Linkouts
InParanoid A subset of ortholog calls from InParanoid.
OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs.
hide Stocks & Reagents
hide Stocks Listed in FlyBase ( 6 )
Bloomington
VDRC
hide Genomic Clones ( 2 )
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
hide cDNA Clones ( 30 )
Please Note
This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
hide RNAi & Array Information
Linkouts
DRSC - Results from RNAi screens.
GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
hide Antibody Information
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hide Identification
hide Relationship to Other Genes
Source for database identity of
Source for identity of: Tim8 CG1728
Source for database merge of
Source for merge of: Tim8 BcDNA:SD06593
Additional comments
Source for merge of Tim8 BcDNA:SD06593 was a shared cDNA (date:030728).
hide Other Comments
hide External Crossreferences & Linkouts
Sequence Crossreferences
RefSeq (Transcripts)
RefSeq (Proteins)
Entrez Gene - A searchable database of RefSeq genes.
Other Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins
  • MTDROME01728
Linkouts
BioGRID - A database of protein and genetic interactions
DPiM - DPiM, Drosophila Protein interaction Map
DroID - A comprehensive database of gene and protein interactions.
DRSC - Results from RNAi screens.
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans
GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
InParanoid A subset of ortholog calls from InParanoid.
InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.
modMine - Data generated by the modENCODE project.
OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs.
hide Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym
BcDNA:SD06593
 
Name Synonym
Tim8
 
Secondary FlyBase IDs
  • FBgn0062891
hide References ( 19 )
Research paper
McGraw et al., 2008, Genetics 179(3): 1395--1408
Post-mating gene expression profiles of female Drosophila melanogaster in response to time and to four male accessory gland proteins. [FBrf0207105]
Ni et al., 2008, Nature Methods 5(1): 49--51
Vector and parameters for targeted transgenic RNA interference in Drosophila melanogaster. [FBrf0200406]
Mack et al., 2006, Proc. Natl. Acad. Sci. USA 103(27): 10358--10363
Mating-responsive genes in reproductive tissues of female Drosophila melanogaster. [FBrf0194111]
Inlow and Restifo, 2004, Genetics 166(2): 835--881
Molecular and comparative genetics of mental retardation. [FBrf0174714]
Supplementary material
The modENCODE Consortium, 2010, Science 330(6012):
DataS14: Gene co-expression clusters. [FBrf0213979]
Mummery-Widmer et al., 2009, Nature 458(7241):
Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Driscoll and Gerstbrein, 2003, Nature Rev. Genet. 4(3):
Dying for a cause: invertebrate genetics takes on human neurodegeneration. [FBrf0159901]
Giot et al., 2003, Science 302(5651):
Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase
Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center
RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510]
Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center
RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327]
FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms.
Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215]
Sardiello et al., 2003.6.11, MitoDrome: A database of Drosophila melanogaster nuclear genes encoding proteins targeted to the mitochondrion.
MitoDrome: A database of Drosophila melanogaster nuclear genes encoding proteins targeted to the mitochondrion. [FBrf0159903]
Oliver, 2001.8.16, File from B. Oliver containing information on ESTs expressed in the Drosophila testis, described in Andrews et al., 2000, Genome Res. 10(12): 2030-2043 (FBrf0132348).
File from B. Oliver containing information on ESTs expressed in the Drosophila testis, described in Andrews et al., 2000, Genome Res. 10(12): 2030-2043 (FBrf0132348). [FBrf0137492]
FlyBase analysis
FlyBase, 1996-, FlyBase inference based on genome sequence analysis.
FlyBase inference based on genome sequence analysis. [FBrf0104946]
Curated genome annotation
Zhong, 1999.11, [Annotations performed at the Celera Jamboreee.]
[Annotations performed at the Celera Jamboreee.] [FBrf0126703]
DNA/RNA sequence record
Bauer, 1999.4.12, GenBank/EMBL/DDBJ: AF142424
Drosophila melanogaster small zinc finger protein Tim8 (Tim8) mRNA, complete cds. [FBrf0113138]
Protein sequence record
Swiss-Prot Project Members, 2000.10.1, UniProtKB: Q9Y1A3
MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8. [FBrf0136217]
Computer file
BDGP Project Members, 2000-, Berkeley Drosophila Genome Project.
Berkeley Drosophila Genome Project. [FBrf0125078]
Automatic genome annotation
FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.]
[Annotations performed at the Celera Jamboreee.] [FBrf0126705]