Gene model reviewed during 5.40
Gene model reviewed during 5.46
Gene model reviewed during 5.52
Heterohexamer; composed of 3 copies of Tim8 and 3 copies of Tim13, named soluble 70 kDa complex. Associates with the TIM22 complex, whose core is composed of Tim22 (By similarity).
The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of Tim8 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (By similarity).
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Tim8 using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Tim8 in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.