• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • RNA-Seq Search
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • GBrowse 2 Beta
    • CytoSearch
    • Feature Mapper
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Current release
  • Archived releases
  • Map Conversion
  • FTP site:
  • Releases (FTP)
  • Genomes (FTP)
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Vectors & Constructs
  • Other links:
  • BDGP
  • DGRC
  • DIS by issue
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\Stam

General Information
Symbol	Dmel\Stam	Species	D. melanogaster
Name	Signal transducing adaptor molecule	Annotation symbol	CG6521
Feature type	protein_coding_gene	FlyBase ID	FBgn0027363
Gene Model Status	Current	Stock availability	6 publicly available
Also Known As	Dstam
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	32B2-32B3	Sequence location	2L:10,858,536..10,862,006 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Signal transducing adaptor molecule is referred to in FlyBase by the symbol Dmel\Stam (CG6521, FBgn0027363). It is a protein_coding_gene from Drosophila melanogaster. It is reported to have molecular function: JAK pathway signal transduction adaptor activity. There is experimental evidence that it is involved in the biological process: wound healing; epithelial cell migration, open tracheal system. 7 alleles are reported. The phenotype of these alleles is annotated with: trichogen cell. It has one annotated transcript and one annotated polypeptide. Protein features are: ENTH/VHS; Src homology-3 domain; Ubiquitin interacting motif; VHS; VHS subgroup. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed during late larval stages, during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval midgut, larval hindgut, larval Malpighian tubules, larval fat body, virgin spermatheca. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, adult midgut, adult hindgut, adult Malpighian tubules, adult heart, adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1635260_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Stam. Gene sequence location is 2L:10858536..10862006.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 32B2-32B3   Limits computationally determined from genome sequence between P{PZ}dbf1 and P{lacW}SCARk03107
Experimentally Determined Cytological Location
Cytogenetic map Notes References 32B-32B     (Reich, 1999.1.21) 32C-32C     (Mesilaty-Gross, 1999.1.20) 32A-32A   Determined by comparing Celera genomic sequence with sequence from BDGP BAC and P1 clones.   (Lloyd et al., 2000)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Stam for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.45
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Stam-RA FBtr0080143  NM_058100   2854   689
Additional Transcript Data & Comments
Reported size (kB)	2.85 (longest cDNA) (Mesilaty-Gross et al., 1999)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Stam-PA   FBpp0079732   74.6   689   5.31     NP_477448   AAF53027
Additional Polypeptide Data & Comments
Reported size (kDa)	689 (aa) (Mesilaty-Gross et al., 1999)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • VHS subgroup (IPR018205) Src homology-3 domain (IPR001452) VHS (IPR002014) Ubiquitin interacting motif (IPR003903) ENTH/VHS (IPR008942)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202442   AA390353   AA440848   AA698894   AA941925   AA949069   AE014134 AAF53027   AC007186   AF121359 AAD34350   AF121361 AAD37503   AI386649   AI389464   AI405886   AW942028   BE976901   BG637691   BI168857   BI239437   BI240216   BI357623   BI372887   BI484726   BI485093   BI564969   BI611119   BP541101   BT006014 AAO74697   CK657819   CO191085   CO270955   CO271535   CO275171   CO292259   CO310596   CO311035   CO314319   CO317544   CO331840   EC059860   EC060095   EC078669   EC084761   EC087151   EC195223   EC202955   EC205194   EC205888   EC210591   EC210760   EC211039   EC218384   EC220997   EC227016   GH749365   GH753507   GH782780   GH807091   GH814855   GH830160   GH847329   GH861269   GH863707   GH870967   GH872919   GH904470   GH905027   GH905934   GH926020   GH930539
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9XTL2
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References point mutation Stam[2L2896]-1 2L:10,858,850..10,858,850 na_change=C10858850T reported_na_change=C16T pr_change=Q6@ | Stam-PA reported_pr_change=Q6@ (Chanut-Delalande et al., 2007) point mutation Stam[2L2896]-2 2L:10,860,898..10,860,898 na_change=G10860898A reported_na_change=G1513A pr_change=A505T | Stam-PA reported_pr_change=A505T (Chanut-Delalande et al., 2007) point mutation Stam[2L3297]-1 2L:10,860,668..10,860,668 reported_pr_change=F428S pr_change=F428S | Stam-PA na_change=T10860668C reported_na_change=T1283C (Chanut-Delalande et al., 2007) point mutation Stam[2L3297]-2 2L:10,861,033..10,861,033 na_change=T10861033C reported_na_change=T1583C pr_change=Y528H | Stam-PA reported_pr_change=Y528H (Chanut-Delalande et al., 2007)
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism | ubiquitous   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4   organism | ubiquitous & uniform   (Mesilaty-Gross et al., 1999) embryonic stage 4 -- 6   organism   (Fisher et al., 2012) embryonic stage 11 -- 12   midline primordium   (Fisher et al., 2012) midline ventral glial cell   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) ventral midline neuroblast   (Fisher et al., 2012) embryonic stage 11 -- 13   ventral nerve cord | segmentally repeated   (Mesilaty-Gross et al., 1999) embryonic stage 13 -- 16   embryonic brain   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) ventral midline   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012) adult stage | femaleoogenesis stage S9 -- S14   nurse cell   • cytoplasm (Mesilaty-Gross et al., 1999) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Mesilaty-Gross et al., 1999) embryonic stage 4     (Mesilaty-Gross et al., 1999) embryonic stage 7 -- 17   organism | segmentally repeated   (Mesilaty-Gross et al., 1999) embryonic stage 14 -- 17   ventral nerve cord | restricted   (Mesilaty-Gross et al., 1999) adult stage & oogenesis   oocyte   (Mesilaty-Gross et al., 1999) adult stageoogenesis stage S9 -- S10   nurse cell   (Mesilaty-Gross et al., 1999) adult stageoogenesis stage S9 -- S14     (Mesilaty-Gross et al., 1999)
Additional Descriptive Data
	Stam and ial transcripts are detected in all developmental stages, but are at highest levels in embryos and adults. Stam and ial transcripts are detected at very high levels in syncytial blastoderm embryos. From stage 7 onwards, a segmentally repeated pattern is visible for both transcripts. Expression is detected in the developing ventral nerve cord; later, a limited number of cells in the condensed nerve cord continue to express Stam and ial transcripts. Stam and ial transcript expression is also detected during oogenesis, starting at stage S9. In stages S9-S10, expression is high in the nurse cell cytoplasm. Transcript is detected in deposited eggs. (Mesilaty-Gross et al., 1999)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval midgut, larval hindgut, larval Malpighian tubules, larval fat body, virgin spermatheca. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, adult midgut, adult hindgut, adult Malpighian tubules, adult heart, adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    376.8 Larval Midgut    756.3 Larval Hindgut    635.9 Larval Malpighian Tubules    1297.9 Larval Fat Body    865.6 Larval Salivary Gland    377.1 Larval Trachea    222.85 Larval Carcass    334.325 Adult Head    259.4 Adult Eye    362.15 Adult Brain    262 Adult Thoracic-Abdominal Ganglion    247.4 Adult Crop    289.7 Adult Midgut    400.6 Adult Hindgut    252.9 Adult Malpighian Tubules    253.4 Adult Fat Body    428.1 Adult Salivary Gland    310.1 Adult Heart    251.475 Adult VirginFemale Spermatheca    544.8 Adult InseminatedFemale Spermatheca    348.1 Adult Ovary    292.4 Adult Testis    227.2 Adult Male Accessory Gland    216.9 Adult Carcass    228.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    376.8 Larval Midgut  (756.3) Larval Hindgut  (635.9) Larval Malpighian Tubules  (1297.9) Larval Fat Body  (865.6) Larval Salivary Gland    377.1 Larval Trachea    222.85 Larval Carcass    334.325 Adult Head    259.4 Adult Eye    362.15 Adult Brain    262 Adult Thoracic-Abdominal Ganglion    247.4 Adult Crop    289.7 Adult Midgut    400.6 Adult Hindgut    252.9 Adult Malpighian Tubules    253.4 Adult Fat Body    428.1 Adult Salivary Gland    310.1 Adult Heart    251.475 Adult VirginFemale Spermatheca  (544.8) Adult InseminatedFemale Spermatheca    348.1 Adult Ovary    292.4 Adult Testis    227.2 Adult Male Accessory Gland    216.9 Adult Carcass    228.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    376.8 Larval Midgut    756.3 Larval Hindgut    635.9 Larval Malpighian Tubules  (1297.9) Larval Fat Body    865.6 Larval Salivary Gland    377.1 Larval Trachea    222.85 Larval Carcass    334.325 Adult Head    259.4 Adult Eye    362.15 Adult Brain    262 Adult Thoracic-Abdominal Ganglion    247.4 Adult Crop    289.7 Adult Midgut    400.6 Adult Hindgut    252.9 Adult Malpighian Tubules    253.4 Adult Fat Body    428.1 Adult Salivary Gland    310.1 Adult Heart    251.475 Adult VirginFemale Spermatheca    544.8 Adult InseminatedFemale Spermatheca    348.1 Adult Ovary    292.4 Adult Testis    227.2 Adult Male Accessory Gland    216.9 Adult Carcass    228.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    376.8 Larval Midgut    756.3 Larval Hindgut    635.9 Larval Malpighian Tubules    1297.9 Larval Fat Body    865.6 Larval Salivary Gland    377.1 Larval Trachea    222.85 Larval Carcass    334.325 Adult Head    259.4 Adult Eye    362.15 Adult Brain    262 Adult Thoracic-Abdominal Ganglion    247.4 Adult Crop    289.7 Adult Midgut    400.6 Adult Hindgut    252.9 Adult Malpighian Tubules    253.4 Adult Fat Body    428.1 Adult Salivary Gland    310.1 Adult Heart    251.475 Adult VirginFemale Spermatheca    544.8 Adult InseminatedFemale Spermatheca    348.1 Adult Ovary    292.4 Adult Testis    227.2 Adult Male Accessory Gland    216.9 Adult Carcass    228.5 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    376.8 Larval Midgut    756.3 Larval Hindgut    635.9 Larval Malpighian Tubules    1297.9 Larval Fat Body    865.6 Larval Salivary Gland    377.1 Larval Trachea    222.85 Larval Carcass    334.325 Adult Head    259.4 Adult Eye    362.15 Adult Brain    262 Adult Thoracic-Abdominal Ganglion    247.4 Adult Crop    289.7 Adult Midgut    400.6 Adult Hindgut    252.9 Adult Malpighian Tubules    253.4 Adult Fat Body    428.1 Adult Salivary Gland    310.1 Adult Heart    251.475 Adult VirginFemale Spermatheca    544.8 Adult InseminatedFemale Spermatheca    348.1 Adult Ovary    292.4 Adult Testis    227.2 Adult Male Accessory Gland    216.9 Adult Carcass    228.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    376.8 Larval Midgut  756.3 Larval Hindgut  635.9 Larval Malpighian Tubules  (1297.9) Larval Fat Body  (865.6) Larval Salivary Gland    377.1 Larval Trachea    222.85 Larval Carcass    334.325 Adult Head    259.4 Adult Eye    362.15 Adult Brain    262 Adult Thoracic-Abdominal Ganglion    247.4 Adult Crop    289.7 Adult Midgut    400.6 Adult Hindgut    252.9 Adult Malpighian Tubules    253.4 Adult Fat Body    428.1 Adult Salivary Gland    310.1 Adult Heart    251.475 Adult VirginFemale Spermatheca  544.8 Adult InseminatedFemale Spermatheca    348.1 Adult Ovary    292.4 Adult Testis    227.2 Adult Male Accessory Gland    216.9 Adult Carcass    228.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    376.8 Larval Midgut    756.3 Larval Hindgut    635.9 Larval Malpighian Tubules  1297.9 Larval Fat Body    865.6 Larval Salivary Gland    377.1 Larval Trachea    222.85 Larval Carcass    334.325 Adult Head    259.4 Adult Eye    362.15 Adult Brain    262 Adult Thoracic-Abdominal Ganglion    247.4 Adult Crop    289.7 Adult Midgut    400.6 Adult Hindgut    252.9 Adult Malpighian Tubules    253.4 Adult Fat Body    428.1 Adult Salivary Gland    310.1 Adult Heart    251.475 Adult VirginFemale Spermatheca    544.8 Adult InseminatedFemale Spermatheca    348.1 Adult Ovary    292.4 Adult Testis    227.2 Adult Male Accessory Gland    216.9 Adult Carcass    228.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    376.8 Larval Midgut    756.3 Larval Hindgut    635.9 Larval Malpighian Tubules    1297.9 Larval Fat Body    865.6 Larval Salivary Gland    377.1 Larval Trachea    222.85 Larval Carcass    334.325 Adult Head    259.4 Adult Eye    362.15 Adult Brain    262 Adult Thoracic-Abdominal Ganglion    247.4 Adult Crop    289.7 Adult Midgut    400.6 Adult Hindgut    252.9 Adult Malpighian Tubules    253.4 Adult Fat Body    428.1 Adult Salivary Gland    310.1 Adult Heart    251.475 Adult VirginFemale Spermatheca    544.8 Adult InseminatedFemale Spermatheca    348.1 Adult Ovary    292.4 Adult Testis    227.2 Adult Male Accessory Gland    216.9 Adult Carcass    228.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    259.4   NA  Eye    362.15   NA  Brain    262   376.8  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    247.4   NA  Crop    289.7   756.3  Midgut    400.6   635.9  Hindgut    252.9   1297.9  Malpighian Tubules    253.4   865.6  Fat Body    428.1   377.1  Salivary Gland    310.1   NA  Heart    251.475   222.85  Trachea    NA   NA  VirginFemale Spermatheca    544.8   NA  InseminatedFemale Spermatheca    348.1   NA  Ovary    292.4   NA  Testis    227.2   NA  Male Accessory Gland    216.9   334.325  Carcass    228.5 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    71 central nervous system, larvae L3    106 central nervous system, pupae P8    33 head, virgin 1-day female    35 head, virgin 4-day female    42 head, virgin 20-day female    40 head, mated 1-day female    41 head, mated 4-day female    26 head, mated 20-day female    38 head, mated 1-day male    57 head, mated 4-day male    42 head, mated 20-day male    45 salivary gland, larvae L3 wandering    15 salivary gland, white prepupae    91 digestive system, larvae L3 wandering    212 digestive system, 1-day adult    40 digestive system, 4-day adult    43 digestive system, 20-day adult    56 fat body, larvae L3 wandering    64 fat body, white prepupae    76 fat body, pupae P8    48 carcass, larvae L3 wandering    74 carcass, 1-day adult    28 carcass, 4-day adult    24 carcass, 20-day adult    40 ovary, virgin 4-day female    37 ovary, mated 4-day female    51 testis, mated 4-day male    27 accessory gland, mated 4-day male    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (71) central nervous system, larvae L3  (106) central nervous system, pupae P8  (33) head, virgin 1-day female  (35) head, virgin 4-day female  (42) head, virgin 20-day female  (40) head, mated 1-day female  (41) head, mated 4-day female  26 head, mated 20-day female  (38) head, mated 1-day male  (57) head, mated 4-day male  (42) head, mated 20-day male  (45) salivary gland, larvae L3 wandering    15 salivary gland, white prepupae  (91) digestive system, larvae L3 wandering  (212) digestive system, 1-day adult  (40) digestive system, 4-day adult  (43) digestive system, 20-day adult  (56) fat body, larvae L3 wandering  (64) fat body, white prepupae  (76) fat body, pupae P8  (48) carcass, larvae L3 wandering  (74) carcass, 1-day adult  (28) carcass, 4-day adult    24 carcass, 20-day adult  (40) ovary, virgin 4-day female  (37) ovary, mated 4-day female  (51) testis, mated 4-day male  (27) accessory gland, mated 4-day male    25 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    71 central nervous system, larvae L3  106 central nervous system, pupae P8    33 head, virgin 1-day female    35 head, virgin 4-day female    42 head, virgin 20-day female    40 head, mated 1-day female    41 head, mated 4-day female    26 head, mated 20-day female    38 head, mated 1-day male    57 head, mated 4-day male    42 head, mated 20-day male    45 salivary gland, larvae L3 wandering    15 salivary gland, white prepupae    91 digestive system, larvae L3 wandering  (212) digestive system, 1-day adult    40 digestive system, 4-day adult    43 digestive system, 20-day adult    56 fat body, larvae L3 wandering    64 fat body, white prepupae    76 fat body, pupae P8    48 carcass, larvae L3 wandering    74 carcass, 1-day adult    28 carcass, 4-day adult    24 carcass, 20-day adult    40 ovary, virgin 4-day female    37 ovary, mated 4-day female    51 testis, mated 4-day male    27 accessory gland, mated 4-day male    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    71 central nervous system, larvae L3    106 central nervous system, pupae P8    33 head, virgin 1-day female    35 head, virgin 4-day female    42 head, virgin 20-day female    40 head, mated 1-day female    41 head, mated 4-day female    26 head, mated 20-day female    38 head, mated 1-day male    57 head, mated 4-day male    42 head, mated 20-day male    45 salivary gland, larvae L3 wandering    15 salivary gland, white prepupae    91 digestive system, larvae L3 wandering    212 digestive system, 1-day adult    40 digestive system, 4-day adult    43 digestive system, 20-day adult    56 fat body, larvae L3 wandering    64 fat body, white prepupae    76 fat body, pupae P8    48 carcass, larvae L3 wandering    74 carcass, 1-day adult    28 carcass, 4-day adult    24 carcass, 20-day adult    40 ovary, virgin 4-day female    37 ovary, mated 4-day female    51 testis, mated 4-day male    27 accessory gland, mated 4-day male    25 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    71 central nervous system, larvae L3    106 central nervous system, pupae P8    33 head, virgin 1-day female    35 head, virgin 4-day female    42 head, virgin 20-day female    40 head, mated 1-day female    41 head, mated 4-day female    26 head, mated 20-day female    38 head, mated 1-day male    57 head, mated 4-day male    42 head, mated 20-day male    45 salivary gland, larvae L3 wandering    15 salivary gland, white prepupae    91 digestive system, larvae L3 wandering    212 digestive system, 1-day adult    40 digestive system, 4-day adult    43 digestive system, 20-day adult    56 fat body, larvae L3 wandering    64 fat body, white prepupae    76 fat body, pupae P8    48 carcass, larvae L3 wandering    74 carcass, 1-day adult    28 carcass, 4-day adult    24 carcass, 20-day adult    40 ovary, virgin 4-day female    37 ovary, mated 4-day female    51 testis, mated 4-day male    27 accessory gland, mated 4-day male    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (71) central nervous system, larvae L3  (106) central nervous system, pupae P8  (33) head, virgin 1-day female  (35) head, virgin 4-day female  (42) head, virgin 20-day female  (40) head, mated 1-day female  (41) head, mated 4-day female  26 head, mated 20-day female  (38) head, mated 1-day male  (57) head, mated 4-day male  (42) head, mated 20-day male  (45) salivary gland, larvae L3 wandering    15 salivary gland, white prepupae  (91) digestive system, larvae L3 wandering  (212) digestive system, 1-day adult  (40) digestive system, 4-day adult  (43) digestive system, 20-day adult  (56) fat body, larvae L3 wandering  (64) fat body, white prepupae  (76) fat body, pupae P8  (48) carcass, larvae L3 wandering  (74) carcass, 1-day adult  28 carcass, 4-day adult    24 carcass, 20-day adult  (40) ovary, virgin 4-day female  (37) ovary, mated 4-day female  (51) testis, mated 4-day male  27 accessory gland, mated 4-day male    25 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    71 central nervous system, larvae L3  106 central nervous system, pupae P8    33 head, virgin 1-day female    35 head, virgin 4-day female    42 head, virgin 20-day female    40 head, mated 1-day female    41 head, mated 4-day female    26 head, mated 20-day female    38 head, mated 1-day male    57 head, mated 4-day male    42 head, mated 20-day male    45 salivary gland, larvae L3 wandering    15 salivary gland, white prepupae    91 digestive system, larvae L3 wandering  (212) digestive system, 1-day adult    40 digestive system, 4-day adult    43 digestive system, 20-day adult    56 fat body, larvae L3 wandering    64 fat body, white prepupae    76 fat body, pupae P8    48 carcass, larvae L3 wandering    74 carcass, 1-day adult    28 carcass, 4-day adult    24 carcass, 20-day adult    40 ovary, virgin 4-day female    37 ovary, mated 4-day female    51 testis, mated 4-day male    27 accessory gland, mated 4-day male    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    71 central nervous system, larvae L3    106 central nervous system, pupae P8    33 head, virgin 1-day female    35 head, virgin 4-day female    42 head, virgin 20-day female    40 head, mated 1-day female    41 head, mated 4-day female    26 head, mated 20-day female    38 head, mated 1-day male    57 head, mated 4-day male    42 head, mated 20-day male    45 salivary gland, larvae L3 wandering    15 salivary gland, white prepupae    91 digestive system, larvae L3 wandering    212 digestive system, 1-day adult    40 digestive system, 4-day adult    43 digestive system, 20-day adult    56 fat body, larvae L3 wandering    64 fat body, white prepupae    76 fat body, pupae P8    48 carcass, larvae L3 wandering    74 carcass, 1-day adult    28 carcass, 4-day adult    24 carcass, 20-day adult    40 ovary, virgin 4-day female    37 ovary, mated 4-day female    51 testis, mated 4-day male    27 accessory gland, mated 4-day male    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed during late larval stages, during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    42 embryo 02-04hr    49 embryo 04-06hr    14 embryo 06-08hr    23 embryo 08-10hr    32 embryo 10-12hr    35 embryo 12-14hr    27 embryo 14-16hr    27 embryo 16-18hr    25 embryo 18-20hr    25 embryo 20-22hr    27 embryo 22-24hr    24 larva L1    12 larva L2    11 larva L3 12hr old    11 larva L3 puffstage 1-2    24 larva L3 puffstage 3-6    63 larva L3 puffstage 7-9    104 white prepupae new    85 white prepupae 12hr    52 white prepupae 24hr    41 pupae 2d postWPP    27 pupae 3d postWPP    15 pupae 4d postWPP    17 adult male 01day    23 adult male 05day    27 adult male 30day    27 adult female 01day    22 adult female 05day    27 adult female 30day    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (42) embryo 02-04hr  (49) embryo 04-06hr    14 embryo 06-08hr    23 embryo 08-10hr  (32) embryo 10-12hr  (35) embryo 12-14hr  (27) embryo 14-16hr  (27) embryo 16-18hr    25 embryo 18-20hr    25 embryo 20-22hr  (27) embryo 22-24hr    24 larva L1    12 larva L2    11 larva L3 12hr old    11 larva L3 puffstage 1-2    24 larva L3 puffstage 3-6  (63) larva L3 puffstage 7-9  (104) white prepupae new  (85) white prepupae 12hr  (52) white prepupae 24hr  (41) pupae 2d postWPP  (27) pupae 3d postWPP    15 pupae 4d postWPP    17 adult male 01day    23 adult male 05day  (27) adult male 30day  (27) adult female 01day    22 adult female 05day  (27) adult female 30day  (29) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    42 embryo 02-04hr    49 embryo 04-06hr    14 embryo 06-08hr    23 embryo 08-10hr    32 embryo 10-12hr    35 embryo 12-14hr    27 embryo 14-16hr    27 embryo 16-18hr    25 embryo 18-20hr    25 embryo 20-22hr    27 embryo 22-24hr    24 larva L1    12 larva L2    11 larva L3 12hr old    11 larva L3 puffstage 1-2    24 larva L3 puffstage 3-6    63 larva L3 puffstage 7-9  104 white prepupae new    85 white prepupae 12hr    52 white prepupae 24hr    41 pupae 2d postWPP    27 pupae 3d postWPP    15 pupae 4d postWPP    17 adult male 01day    23 adult male 05day    27 adult male 30day    27 adult female 01day    22 adult female 05day    27 adult female 30day    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    42 embryo 02-04hr    49 embryo 04-06hr    14 embryo 06-08hr    23 embryo 08-10hr    32 embryo 10-12hr    35 embryo 12-14hr    27 embryo 14-16hr    27 embryo 16-18hr    25 embryo 18-20hr    25 embryo 20-22hr    27 embryo 22-24hr    24 larva L1    12 larva L2    11 larva L3 12hr old    11 larva L3 puffstage 1-2    24 larva L3 puffstage 3-6    63 larva L3 puffstage 7-9    104 white prepupae new    85 white prepupae 12hr    52 white prepupae 24hr    41 pupae 2d postWPP    27 pupae 3d postWPP    15 pupae 4d postWPP    17 adult male 01day    23 adult male 05day    27 adult male 30day    27 adult female 01day    22 adult female 05day    27 adult female 30day    29 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    42 embryo 02-04hr    49 embryo 04-06hr    14 embryo 06-08hr    23 embryo 08-10hr    32 embryo 10-12hr    35 embryo 12-14hr    27 embryo 14-16hr    27 embryo 16-18hr    25 embryo 18-20hr    25 embryo 20-22hr    27 embryo 22-24hr    24 larva L1    12 larva L2    11 larva L3 12hr old    11 larva L3 puffstage 1-2    24 larva L3 puffstage 3-6    63 larva L3 puffstage 7-9    104 white prepupae new    85 white prepupae 12hr    52 white prepupae 24hr    41 pupae 2d postWPP    27 pupae 3d postWPP    15 pupae 4d postWPP    17 adult male 01day    23 adult male 05day    27 adult male 30day    27 adult female 01day    22 adult female 05day    27 adult female 30day    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (42) embryo 02-04hr  (49) embryo 04-06hr    14 embryo 06-08hr    23 embryo 08-10hr  32 embryo 10-12hr  (35) embryo 12-14hr  27 embryo 14-16hr  27 embryo 16-18hr    25 embryo 18-20hr    25 embryo 20-22hr  27 embryo 22-24hr    24 larva L1    12 larva L2    11 larva L3 12hr old    11 larva L3 puffstage 1-2    24 larva L3 puffstage 3-6  (63) larva L3 puffstage 7-9  (104) white prepupae new  (85) white prepupae 12hr  (52) white prepupae 24hr  (41) pupae 2d postWPP  27 pupae 3d postWPP    15 pupae 4d postWPP    17 adult male 01day    23 adult male 05day  27 adult male 30day  27 adult female 01day    22 adult female 05day  27 adult female 30day  29 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    42 embryo 02-04hr    49 embryo 04-06hr    14 embryo 06-08hr    23 embryo 08-10hr    32 embryo 10-12hr    35 embryo 12-14hr    27 embryo 14-16hr    27 embryo 16-18hr    25 embryo 18-20hr    25 embryo 20-22hr    27 embryo 22-24hr    24 larva L1    12 larva L2    11 larva L3 12hr old    11 larva L3 puffstage 1-2    24 larva L3 puffstage 3-6    63 larva L3 puffstage 7-9  104 white prepupae new    85 white prepupae 12hr    52 white prepupae 24hr    41 pupae 2d postWPP    27 pupae 3d postWPP    15 pupae 4d postWPP    17 adult male 01day    23 adult male 05day    27 adult male 30day    27 adult female 01day    22 adult female 05day    27 adult female 30day    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    42 embryo 02-04hr    49 embryo 04-06hr    14 embryo 06-08hr    23 embryo 08-10hr    32 embryo 10-12hr    35 embryo 12-14hr    27 embryo 14-16hr    27 embryo 16-18hr    25 embryo 18-20hr    25 embryo 20-22hr    27 embryo 22-24hr    24 larva L1    12 larva L2    11 larva L3 12hr old    11 larva L3 puffstage 1-2    24 larva L3 puffstage 3-6    63 larva L3 puffstage 7-9    104 white prepupae new    85 white prepupae 12hr    52 white prepupae 24hr    41 pupae 2d postWPP    27 pupae 3d postWPP    15 pupae 4d postWPP    17 adult male 01day    23 adult male 05day    27 adult male 30day    27 adult female 01day    22 adult female 05day    27 adult female 30day    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    96 Schneider line 2 Sg4    38 embryonic 1182-4H    62 embryonic GM2    48 embryonic Kc167    60 embryonic S1    127 embryonic S3    38 leg disc CME L1    64 wing disc CME-W2    43 wing disc ML-DmD8    30 wing disc ML-DmD9    65 wing disc ML-DmD16-c3    74 wing disc ML-DmD21    59 wing disc ML-DmD32    56 haltere disc ML-DmD17-c3    55 eye-antennal disc ML-DmD11    54 antennal disc ML-DmD20-c5    36 mixed discs ML-DmD4-c1    39 CNS ML-DmBG1-c1    57 CNS ML-DmBG2-c2    45 tumorous blood cells mbn2    57 ovary fGS/OSS    63 ovary OSC    63 ovary OSS    34 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (96) Schneider line 2 Sg4  (38) embryonic 1182-4H  (62) embryonic GM2  (48) embryonic Kc167  (60) embryonic S1  (127) embryonic S3  (38) leg disc CME L1  (64) wing disc CME-W2  (43) wing disc ML-DmD8  (30) wing disc ML-DmD9  (65) wing disc ML-DmD16-c3  (74) wing disc ML-DmD21  (59) wing disc ML-DmD32  (56) haltere disc ML-DmD17-c3  (55) eye-antennal disc ML-DmD11  (54) antennal disc ML-DmD20-c5  (36) mixed discs ML-DmD4-c1  (39) CNS ML-DmBG1-c1  (57) CNS ML-DmBG2-c2  (45) tumorous blood cells mbn2  (57) ovary fGS/OSS  (63) ovary OSC  (63) ovary OSS  (34) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    96 Schneider line 2 Sg4    38 embryonic 1182-4H    62 embryonic GM2    48 embryonic Kc167    60 embryonic S1  (127) embryonic S3    38 leg disc CME L1    64 wing disc CME-W2    43 wing disc ML-DmD8    30 wing disc ML-DmD9    65 wing disc ML-DmD16-c3    74 wing disc ML-DmD21    59 wing disc ML-DmD32    56 haltere disc ML-DmD17-c3    55 eye-antennal disc ML-DmD11    54 antennal disc ML-DmD20-c5    36 mixed discs ML-DmD4-c1    39 CNS ML-DmBG1-c1    57 CNS ML-DmBG2-c2    45 tumorous blood cells mbn2    57 ovary fGS/OSS    63 ovary OSC    63 ovary OSS    34 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    96 Schneider line 2 Sg4    38 embryonic 1182-4H    62 embryonic GM2    48 embryonic Kc167    60 embryonic S1    127 embryonic S3    38 leg disc CME L1    64 wing disc CME-W2    43 wing disc ML-DmD8    30 wing disc ML-DmD9    65 wing disc ML-DmD16-c3    74 wing disc ML-DmD21    59 wing disc ML-DmD32    56 haltere disc ML-DmD17-c3    55 eye-antennal disc ML-DmD11    54 antennal disc ML-DmD20-c5    36 mixed discs ML-DmD4-c1    39 CNS ML-DmBG1-c1    57 CNS ML-DmBG2-c2    45 tumorous blood cells mbn2    57 ovary fGS/OSS    63 ovary OSC    63 ovary OSS    34 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    96 Schneider line 2 Sg4    38 embryonic 1182-4H    62 embryonic GM2    48 embryonic Kc167    60 embryonic S1    127 embryonic S3    38 leg disc CME L1    64 wing disc CME-W2    43 wing disc ML-DmD8    30 wing disc ML-DmD9    65 wing disc ML-DmD16-c3    74 wing disc ML-DmD21    59 wing disc ML-DmD32    56 haltere disc ML-DmD17-c3    55 eye-antennal disc ML-DmD11    54 antennal disc ML-DmD20-c5    36 mixed discs ML-DmD4-c1    39 CNS ML-DmBG1-c1    57 CNS ML-DmBG2-c2    45 tumorous blood cells mbn2    57 ovary fGS/OSS    63 ovary OSC    63 ovary OSS    34 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (96) Schneider line 2 Sg4  (38) embryonic 1182-4H  (62) embryonic GM2  (48) embryonic Kc167  (60) embryonic S1  (127) embryonic S3  (38) leg disc CME L1  (64) wing disc CME-W2  (43) wing disc ML-DmD8  30 wing disc ML-DmD9  (65) wing disc ML-DmD16-c3  (74) wing disc ML-DmD21  (59) wing disc ML-DmD32  (56) haltere disc ML-DmD17-c3  (55) eye-antennal disc ML-DmD11  (54) antennal disc ML-DmD20-c5  (36) mixed discs ML-DmD4-c1  (39) CNS ML-DmBG1-c1  (57) CNS ML-DmBG2-c2  (45) tumorous blood cells mbn2  (57) ovary fGS/OSS  (63) ovary OSC  (63) ovary OSS  (34) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    96 Schneider line 2 Sg4    38 embryonic 1182-4H    62 embryonic GM2    48 embryonic Kc167    60 embryonic S1  127 embryonic S3    38 leg disc CME L1    64 wing disc CME-W2    43 wing disc ML-DmD8    30 wing disc ML-DmD9    65 wing disc ML-DmD16-c3    74 wing disc ML-DmD21    59 wing disc ML-DmD32    56 haltere disc ML-DmD17-c3    55 eye-antennal disc ML-DmD11    54 antennal disc ML-DmD20-c5    36 mixed discs ML-DmD4-c1    39 CNS ML-DmBG1-c1    57 CNS ML-DmBG2-c2    45 tumorous blood cells mbn2    57 ovary fGS/OSS    63 ovary OSC    63 ovary OSS    34 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    96 Schneider line 2 Sg4    38 embryonic 1182-4H    62 embryonic GM2    48 embryonic Kc167    60 embryonic S1    127 embryonic S3    38 leg disc CME L1    64 wing disc CME-W2    43 wing disc ML-DmD8    30 wing disc ML-DmD9    65 wing disc ML-DmD16-c3    74 wing disc ML-DmD21    59 wing disc ML-DmD32    56 haltere disc ML-DmD17-c3    55 eye-antennal disc ML-DmD11    54 antennal disc ML-DmD20-c5    36 mixed discs ML-DmD4-c1    39 CNS ML-DmBG1-c1    57 CNS ML-DmBG2-c2    45 tumorous blood cells mbn2    57 ovary fGS/OSS    63 ovary OSC    63 ovary OSS    34 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    94 cold shock, 4-day adult    79 heat shock, 4-day adult    35 Cadmium 50 mM 6 hrs, larvae L3    29 Cadmium 50 mM 12 hrs, larvae L3    32 Cadmium 50 mM 48 hrs, 4-day adult    33 Cadmium 100 mM 48 hrs, 4-day adult    49 Copper 0.5 mM 12 hrs, larvae L3    62 Copper 15 mM 48 hrs, 4-day adult    26 Zinc 5 mM 12 hrs, larvae L3    56 Zinc 4.5 mM 48 hrs, 4-day adult    35 Ethanol 2.5% 3 hrs, larvae L3    50 Ethanol 5% 3 hrs, larvae L3    27 Ethanol 10% 3 hrs, larvae L3    30 Caffeine 1.5 mg/ml 4 hrs, larvae L3    26 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    55 Caffeine 25 mg/ml 48 hrs, 4-day adult    85 Paraquat 5 mM 48 hrs, 4-day adult    39 Paraquat 10 mM 48 hrs, 4-day adult    59 Rotenone 2 μg 12 hrs, larvae L3    28 Rotenone 8 μg 12 hrs, larvae L3    28 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (94) cold shock, 4-day adult  (79) heat shock, 4-day adult  (35) Cadmium 50 mM 6 hrs, larvae L3  (29) Cadmium 50 mM 12 hrs, larvae L3  (32) Cadmium 50 mM 48 hrs, 4-day adult  (33) Cadmium 100 mM 48 hrs, 4-day adult  (49) Copper 0.5 mM 12 hrs, larvae L3  (62) Copper 15 mM 48 hrs, 4-day adult  26 Zinc 5 mM 12 hrs, larvae L3  (56) Zinc 4.5 mM 48 hrs, 4-day adult  (35) Ethanol 2.5% 3 hrs, larvae L3  (50) Ethanol 5% 3 hrs, larvae L3  (27) Ethanol 10% 3 hrs, larvae L3  (30) Caffeine 1.5 mg/ml 4 hrs, larvae L3  26 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (55) Caffeine 25 mg/ml 48 hrs, 4-day adult  (85) Paraquat 5 mM 48 hrs, 4-day adult  (39) Paraquat 10 mM 48 hrs, 4-day adult  (59) Rotenone 2 μg 12 hrs, larvae L3  (28) Rotenone 8 μg 12 hrs, larvae L3  (28) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    94 cold shock, 4-day adult    79 heat shock, 4-day adult    35 Cadmium 50 mM 6 hrs, larvae L3    29 Cadmium 50 mM 12 hrs, larvae L3    32 Cadmium 50 mM 48 hrs, 4-day adult    33 Cadmium 100 mM 48 hrs, 4-day adult    49 Copper 0.5 mM 12 hrs, larvae L3    62 Copper 15 mM 48 hrs, 4-day adult    26 Zinc 5 mM 12 hrs, larvae L3    56 Zinc 4.5 mM 48 hrs, 4-day adult    35 Ethanol 2.5% 3 hrs, larvae L3    50 Ethanol 5% 3 hrs, larvae L3    27 Ethanol 10% 3 hrs, larvae L3    30 Caffeine 1.5 mg/ml 4 hrs, larvae L3    26 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    55 Caffeine 25 mg/ml 48 hrs, 4-day adult    85 Paraquat 5 mM 48 hrs, 4-day adult    39 Paraquat 10 mM 48 hrs, 4-day adult    59 Rotenone 2 μg 12 hrs, larvae L3    28 Rotenone 8 μg 12 hrs, larvae L3    28 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    94 cold shock, 4-day adult    79 heat shock, 4-day adult    35 Cadmium 50 mM 6 hrs, larvae L3    29 Cadmium 50 mM 12 hrs, larvae L3    32 Cadmium 50 mM 48 hrs, 4-day adult    33 Cadmium 100 mM 48 hrs, 4-day adult    49 Copper 0.5 mM 12 hrs, larvae L3    62 Copper 15 mM 48 hrs, 4-day adult    26 Zinc 5 mM 12 hrs, larvae L3    56 Zinc 4.5 mM 48 hrs, 4-day adult    35 Ethanol 2.5% 3 hrs, larvae L3    50 Ethanol 5% 3 hrs, larvae L3    27 Ethanol 10% 3 hrs, larvae L3    30 Caffeine 1.5 mg/ml 4 hrs, larvae L3    26 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    55 Caffeine 25 mg/ml 48 hrs, 4-day adult    85 Paraquat 5 mM 48 hrs, 4-day adult    39 Paraquat 10 mM 48 hrs, 4-day adult    59 Rotenone 2 μg 12 hrs, larvae L3    28 Rotenone 8 μg 12 hrs, larvae L3    28 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    94 cold shock, 4-day adult    79 heat shock, 4-day adult    35 Cadmium 50 mM 6 hrs, larvae L3    29 Cadmium 50 mM 12 hrs, larvae L3    32 Cadmium 50 mM 48 hrs, 4-day adult    33 Cadmium 100 mM 48 hrs, 4-day adult    49 Copper 0.5 mM 12 hrs, larvae L3    62 Copper 15 mM 48 hrs, 4-day adult    26 Zinc 5 mM 12 hrs, larvae L3    56 Zinc 4.5 mM 48 hrs, 4-day adult    35 Ethanol 2.5% 3 hrs, larvae L3    50 Ethanol 5% 3 hrs, larvae L3    27 Ethanol 10% 3 hrs, larvae L3    30 Caffeine 1.5 mg/ml 4 hrs, larvae L3    26 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    55 Caffeine 25 mg/ml 48 hrs, 4-day adult    85 Paraquat 5 mM 48 hrs, 4-day adult    39 Paraquat 10 mM 48 hrs, 4-day adult    59 Rotenone 2 μg 12 hrs, larvae L3    28 Rotenone 8 μg 12 hrs, larvae L3    28 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (94) cold shock, 4-day adult  (79) heat shock, 4-day adult  (35) Cadmium 50 mM 6 hrs, larvae L3  29 Cadmium 50 mM 12 hrs, larvae L3  32 Cadmium 50 mM 48 hrs, 4-day adult  (33) Cadmium 100 mM 48 hrs, 4-day adult  (49) Copper 0.5 mM 12 hrs, larvae L3  (62) Copper 15 mM 48 hrs, 4-day adult  26 Zinc 5 mM 12 hrs, larvae L3  (56) Zinc 4.5 mM 48 hrs, 4-day adult  (35) Ethanol 2.5% 3 hrs, larvae L3  (50) Ethanol 5% 3 hrs, larvae L3  27 Ethanol 10% 3 hrs, larvae L3  30 Caffeine 1.5 mg/ml 4 hrs, larvae L3  26 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (55) Caffeine 25 mg/ml 48 hrs, 4-day adult  (85) Paraquat 5 mM 48 hrs, 4-day adult  (39) Paraquat 10 mM 48 hrs, 4-day adult  (59) Rotenone 2 μg 12 hrs, larvae L3  28 Rotenone 8 μg 12 hrs, larvae L3  28 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    94 cold shock, 4-day adult    79 heat shock, 4-day adult    35 Cadmium 50 mM 6 hrs, larvae L3    29 Cadmium 50 mM 12 hrs, larvae L3    32 Cadmium 50 mM 48 hrs, 4-day adult    33 Cadmium 100 mM 48 hrs, 4-day adult    49 Copper 0.5 mM 12 hrs, larvae L3    62 Copper 15 mM 48 hrs, 4-day adult    26 Zinc 5 mM 12 hrs, larvae L3    56 Zinc 4.5 mM 48 hrs, 4-day adult    35 Ethanol 2.5% 3 hrs, larvae L3    50 Ethanol 5% 3 hrs, larvae L3    27 Ethanol 10% 3 hrs, larvae L3    30 Caffeine 1.5 mg/ml 4 hrs, larvae L3    26 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    55 Caffeine 25 mg/ml 48 hrs, 4-day adult    85 Paraquat 5 mM 48 hrs, 4-day adult    39 Paraquat 10 mM 48 hrs, 4-day adult    59 Rotenone 2 μg 12 hrs, larvae L3    28 Rotenone 8 μg 12 hrs, larvae L3    28 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    94 cold shock, 4-day adult    79 heat shock, 4-day adult    35 Cadmium 50 mM 6 hrs, larvae L3    29 Cadmium 50 mM 12 hrs, larvae L3    32 Cadmium 50 mM 48 hrs, 4-day adult    33 Cadmium 100 mM 48 hrs, 4-day adult    49 Copper 0.5 mM 12 hrs, larvae L3    62 Copper 15 mM 48 hrs, 4-day adult    26 Zinc 5 mM 12 hrs, larvae L3    56 Zinc 4.5 mM 48 hrs, 4-day adult    35 Ethanol 2.5% 3 hrs, larvae L3    50 Ethanol 5% 3 hrs, larvae L3    27 Ethanol 10% 3 hrs, larvae L3    30 Caffeine 1.5 mg/ml 4 hrs, larvae L3    26 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    55 Caffeine 25 mg/ml 48 hrs, 4-day adult    85 Paraquat 5 mM 48 hrs, 4-day adult    39 Paraquat 10 mM 48 hrs, 4-day adult    59 Rotenone 2 μg 12 hrs, larvae L3    28 Rotenone 8 μg 12 hrs, larvae L3    28 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_23 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	BDGP expression data • LD02639 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0027363 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6521-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Stam Stages(s) 1-3 Stages(s) 4-6 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | recessive Stam2L2896 Stam2L3297 partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237 StamGD11948 viable Stame00677 Sterility Allele fertile Stame00677 Other Phenotypes Allele visible, with Scer\GAL4pnr-MD237 StamGD11948 Phenotype manifest in Allele dorsal air sac primordium | somatic clone Stam2L3297 Stam2L2896 trichogen cell, with Scer\GAL4pnr-MD237 StamGD11948
Classical Alleles ( 3 )
For All Classical Alleles Show
Allele of Stam Class Mutagen Stocks Known lesion Stame00677 piggyBac transposase 2 -- Stam2L2896 ethyl methanesulfonate 0 Yes Stam2L3297 ethyl methanesulfonate 0 Yes
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Stam Class Mutagen Stocks Known lesion StamGD11948 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes StamHMS01429 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes StamJF02637 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes StamScer\UAS.cCDa in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel7038 (Chanut-Delalande et al., 2007) Df(2L)Exel7049 (Ryder, 2004.4.26, Chanut-Delalande et al., 2007) Df(2L)Exel8026 (Chanut-Delalande et al., 2007)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11948} NA P{TRiP.HMS01429} NA P{TRiP.JF02637} NA P{UAS-Stam.CD} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{RB}Stame00677 NA
Gene Ontology: Function, Process & Cellular Component ( 8 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
epithelial cell migration, open tracheal system inferred from mutant phenotype (Chanut-Delalande et al., 2007) wound healing inferred from mutant phenotype (Campos et al., 2010)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
JAK pathway signal transduction adaptor activity non-traceable author statement (Reich, 1999.1.21)
Biological Process
CV term Evidence References
intracellular protein transport inferred from electronic annotation with InterPro:IPR002014 (FlyBase Curators et al., 2004-) JAK-STAT cascade non-traceable author statement (Reich, 1999.1.21) neurotransmitter secretion non-traceable author statement (Lloyd et al., 2000) regulation of JAK-STAT cascade traceable author statement (Castelli-Gair Hombria and Brown, 2002) synaptic vesicle endocytosis non-traceable author statement (Lloyd et al., 2000)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Stam - CG2183 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Stam - CG3542 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Stam - Cyp6a22 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Stam - Cyp9b2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Stam - alrm anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Stam - γTub37C anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Stam allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 60577 DroID - A comprehensive database of gene and protein interactions. • FBgn0027363 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34505 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q9XTL2
Orthologs
OrthoDB Orthologs (44) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6WH96B Dipteran inclusive ortholog search EOG6J9N7S Insect inclusive ortholog search EOG6C2G5R Arthropod inclusive ortholog search EOG6ZGMTK Metazoa inclusive ortholog search EOG6CCGTD
Orthologs in Drosophila Species (EOG6WH96B)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Stam     Drosophila simulans   Dsim\GD23740 Y   Drosophila sechellia   Dsec\GM18758 Y   Drosophila erecta   Dere\GG23682 Y   Drosophila yakuba   Dyak\GE18494 Y   Drosophila ananassae   Dana\GF15830 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA19660 Y   Drosophila persimilis   Dper\GL19123 Y   Drosophila willistoni   Dwil\GK18440 Y   Drosophila virilis   Dvir\GJ20786 Y   Drosophila mojavensis   Dmoj\GI23591 Y   Drosophila grimshawi   Dgri\GH13592 Y
Orthologs in non-Drosophila Dipterans (EOG6J9N7S)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL002240   Anopheles gambiae Malaria mosquito  Agam\AGAP008494   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ003516
Orthologs in non-Dipteran Insects (EOG6C2G5R)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\Stam   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG005229   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH19972   Atta cephalotes Leafcutter ant  Acep\ACEP24686   Camponotus floridanus Florida carpenter ant  Cflo\CFLO18490   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL23221   Linepithema humile Argentine ant  Lhum\LH20510   Pogonomyrmex barbatus Red harvester ant  Pbar\CG:02546581   Solenopsis invicta Red fire ant  Sinv\SINV24188   Acyrthosiphon pisum Pea aphid  Apim\ACYPI008100   Bombyx mori Silkmoth  Bmor\BGIBMGA003753   Pediculus humanus Human body louse  Phum\PHUM584200   Tribolium castaneum Red flour beetle  Tcas\TC014037
Orthologs in non-Insect Arthropods (EOG6ZGMTK)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\Abcg3l3   Ixodes scapularis Deer tick  Isca\ISCW002328
Orthologs in non-Arthropod Metazoa (EOG6CCGTD)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\stam-1   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_028525gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_011190gn   Danio rerio Zebrafish  Drer\stam   Danio rerio Zebrafish  Drer\stam2   Xenopus tropicalis Western clawed frog  Xtro\stam   Xenopus tropicalis Western clawed frog  Xtro\stam2   Gallus gallus Domestic chicken  Ggal\STAM2   Gallus gallus Domestic chicken  Ggal\STAM   Mus musculus House mouse  Mmus\Stam   Rattus norvegicus Norway rat  Rnor\Stam2   Rattus norvegicus Norway rat  Rnor\Stam   Homo sapiens Human  Hsap\STAM2   Homo sapiens Human  Hsap\STAM
Human Orthologs (2)
Gene OMIM HGNC Hsap\STAM2     Hsap\STAM
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD23740 Drosophila sechellia Dsec\GM18758 Drosophila erecta Dere\GG23682 Drosophila yakuba Dyak\GE18494 Drosophila ananassae Dana\GF15830 Drosophila pseudoobscura pseudoobscura Dpse\GA19660 Drosophila persimilis Dper\GL19123 Drosophila willistoni Dwil\GK18440 Drosophila virilis Dvir\GJ20786 Drosophila mojavensis Dmoj\GI23591 Drosophila grimshawi Dgri\GH13592
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	17879 w1118; PBac{RB}Stame00677 27487 y1 v1; P{TRiP.JF02637}attP2 41808 w*; KrIf-1/CyO; P{UAS-Stam.CD}3 35016 y1 sc* v1; P{TRiP.HMS01429}attP2
Harvard	- PBac{RB}Stame00677
VDRC	v22497 w1118; P{GD11948}v22497
Genomic Clones ( 2 )
	BACR03D06 BACR19N18 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 62 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD02639
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH16790 GH20643 GH26038 LD08961 LD15777 LD27269 LD27824 LP24409 RE09750 RE35921 RE36914 RE44233 RE60079 RE67869 RE68366 RH17245 RH62573
Other clones	14316 38544 40006 42212 47381 80217 118490 163874 179625 274089 bs57d10 CK01.5A.B10 CK01.41B.C5 CK01.62D.F2 CK01.132C.D10 CK01.169B.E1 EK050653 EK101145 EK103817 EK116643 EK199605 EK222101 EK223209 EK235759 EK268454 EK301821 FGA010F02 HL05883 RP003038139 RP003038391 RP003086721 RP003095865 RP003102330 RP003152085 RP003172893 RP003179773 RP003267043 RP003297329 RP003330630 RP003356236 RP003393896 RP003468329 RP003612746 RP003642524
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0027363 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34505
Antibody Information
	polyclonal (Galasso et al., 2007)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	Stam is involved in tracheal cell migration during the morphogenesis of the dorsal air sac primordium. (Chanut-Delalande et al., 2007) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_058100 RefSeq (Proteins) • NP_477448 DDBJ / EMBL / GenBank • AA202442 AAD34350 AAD37503 AAF53027 AAO74697 AC007186 AF121359 AF121361 AW942028 BT006014 Entrez Gene - A searchable database of RefSeq genes. • 34505 UniProtKB/TrEMBL • Q9XTL2
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • VHS subgroup (IPR018205) Src homology-3 domain (IPR001452) VHS (IPR002014) Ubiquitin interacting motif (IPR003903) ENTH/VHS (IPR008942) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD02639
Linkouts
	BioGRID - A database of protein and genetic interactions • 60577 DroID - A comprehensive database of gene and protein interactions. • FBgn0027363 DRSC - Results from RNAi screens. • FBgn0027363 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0027363 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6521-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0027363 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34505 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34505 modMine - Data generated by the modENCODE project. • FBgn0027363 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q9XTL2
Synonyms & Secondary IDs ( 11 )
Reported As
Symbol Synonym	CG6521 (Verstreken and Bellen, 2000.9.4, Gandhi et al., 2007, Perkins et al., 2009, Ni et al., 2011.7.19) Dstam (Hou et al., 2002, Lohi and Lehto, 2001) dstam (Galasso et al., 2007) stam (Zeidler et al., 2000, Chanut-Delalande et al., 2007, Chanut-Delalande et al., 2010, Galasso et al., 2007) STAM (Bischoff and Plowman, 1999, Castelli-Gair Hombria and Brown, 2002, Lohi et al., 2002, Lloyd et al., 2000, Mesilaty-Gross, 1999.1.20, Du et al., 2011) Stam (Chanut-Delalande et al., 2007, Stuart et al., 2007, Moser et al., 2010, Troost et al., 2012, Chanut-Delalande et al., 2010, Campos et al., 2010)
Name Synonym	Signal transducer adaptor molecule (Du et al., 2011) Signal transducing adaptor molecule (Mesilaty-Gross et al., 1999) signal transducing adaptor molecule (Chanut-Delalande et al., 2007) Signal Transducing Adaptor Molecule (Chanut-Delalande et al., 2010) signal-transducing adaptor molecule (Galasso et al., 2007)
Secondary FlyBase IDs
References ( 42 )
Generate a list of	All references relating to this gene ( 42 )
List References by type	Research paper  ( 12 ) Supplementary material  ( 6 ) Review  ( 6 ) Personal communication to FlyBase  ( 9 ) Abstract  ( 1 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 2 ) Website  ( 1 ) Curated genome annotation  ( 2 ) Letter  ( 1 )
Recent research papers ( 3 )
	Bras et al., 2012, J. Cell Sci. 125(20): 4886--4901 Genetic identification of intracellular trafficking regulators involved in Notch-dependent binary cell fate acquisition following asymmetric cell division. [FBrf0220239] Troost et al., 2012, J. Cell Sci. 125(3): 763--776 The tumour suppressor Lethal (2) giant discs is required for the function of the ESCRT-III component Shrub/CHMP4. [FBrf0217584] Du et al., 2011, PLoS ONE 6(9): e24168 In Vivo RNAi Screen Reveals Neddylation Genes as Novel Regulators of Hedgehog Signaling. [FBrf0215574] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...