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Gene Dmel\RecQ5

General Information
Symbol	Dmel\RecQ5	Species	D. melanogaster
Name	homolog of RecQ	Annotation symbol	CG4879
Feature type	protein_coding_gene	FlyBase ID	FBgn0027375
Gene Model Status	Current	Stock availability	6 publicly available
Also Known As	RECQE, DQ1, RECQ5/QE
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	70E5-70E5	Sequence location	3L:14,621,260..14,625,177 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene homolog of RecQ is referred to in FlyBase by the symbol Dmel\RecQ5 (CG4879, FBgn0027375). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: GTP binding; single-stranded DNA-dependent ATP-dependent DNA helicase activity; GTPase activity. There is experimental evidence that it is involved in the biological process: double-strand break repair via single-strand annealing; response to DNA damage stimulus; negative regulation of mitotic cell cycle; response to X-ray; regulation of mitotic anaphase. 14 alleles are reported. The phenotypes of these alleles are annotated with: eye; interommatidial bristle; ommatidial precursor cluster. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: DNA helicase, ATP-dependent, RecQ type; DNA/RNA helicase, DEAD/DEAH box type, N-terminal; Helicase, C-terminal; Helicase, superfamily 1/2, ATP-binding domain; Winged helix-turn-helix transcription repressor DNA-binding domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of very low expression. Peak expression observed within 00-12 and 18-24 hour embryonic stages, during late larval stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult fat body, larval trachea, adult female reproductive system, adult male accessory gland. Comments on Affy2 ProbeSet: ProbeSet 1628264_a_at completely aligns to an exonic region common to each of the 3 FlyBase-annotated transcript isoforms of RecQ5. Gene sequence location is 3L:14621260..14625177.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 70E5-70E5   Limits computationally determined from genome sequence between P{PZ}Mpcp00564 and P{PZ}l(3)rO220rO220
Experimentally Determined Cytological Location
Cytogenetic map Notes References 70D6-70E2   (determined by in situ hybridisation)   (Jeong et al., 2000) 70E1-70E2     (Jeong, 1999.8.13) 70E1-70E2     (Jeong, 1999.8.13) 70E1-70E4     (Sekelsky, 1999.3.10) 70D-70E   (determined by in situ hybridisation)   (Jeong, 1998.3.12)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\RecQ5 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.46
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) RecQ5-RA FBtr0075714  NM_079346   3739   470 RecQ5-RB FBtr0075715  NM_168591   3412   1058 RecQ5-RC FBtr0100362  NM_001014584   3664   468
Additional Transcript Data & Comments
Reported size (kB)	3.4 (northern blot) (Jeong et al., 2000)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein RecQ5-PA   FBpp0075457   53.9   470   8.65     NP_524070   AAF49724 RecQ5-PB   FBpp0075458   121.2   1058   9.43     NP_729983   AAN11801 RecQ5-PC   FBpp0099768   53.7   468   8.65     NP_001014584   AAX52745
Additional Polypeptide Data & Comments
Reported size (kDa)	1058 (aa); 120 (kD observed); 120 (kD predicted) (Jeong et al., 2000) 1057, 470, 468 (aa); 121, 54 (kD predicted) (Sekelsky et al., 1999)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Helicase, C-terminal (IPR001650) DNA helicase, ATP-dependent, RecQ type (IPR004589) DNA/RNA helicase, DEAD/DEAH box type, N-terminal (IPR011545) Helicase, superfamily 1/2, ATP-binding domain (IPR014001) P-loop containing nucleoside triphosphate hydrolase (IPR027417) Winged helix-turn-helix DNA-binding domain (IPR011991)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA735537   AE014296 AAF49724   AE014296 AAN11801   AE014296 AAX52745   AB031086 BAA88312   AB031087 BAA88313   AF134239 AAD43051   AF134239 AAD43052   AF134239 AAD43053   AF171784   AI062257   AI455153   AW940040   AY058252 AAL13481   BH011444   BH011445   BI577316   BI640583   BT032859   CO276885   CO287023   CO298888   CO316466   CO316480   CO321983   CO322347   CO343035   CZ484043   CZ489506   EC051079   EC052604   EC055119   EC056379   EC056430   EC071694   EC081054   EC195454   EC203201   EC226840   EC246314   EC246480   EC249815   EC254897   EV583021   GH944622   GH944697   GH946158   GH947661   GH948764   GH955952   GH957255   GH957882   GH958844   GH960697   GH961216   GH980399
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7YZ98 Q9V433 Q59E27 Q9Y1H2 Q9U5E0 Q9UA31 Q95U81 Q9UA32
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage | early   organism | ubiquitous   (Jeong et al., 2000) embryonic stage -- adult stage     (Jeong et al., 2000) adult stage & oogenesis stage S10   nurse cell   (Jeong et al., 2000) adult stageoogenesis stage S11 -- S12   oocyte   (Jeong et al., 2000)
Additional Descriptive Data
	RecQ5 transcripts are detected throughout development on northern blots with the highest levels in ovaries and early embryos. Transcripts are found to be uniformly distributed in syncytial blastoderm embryos and localized to the periphery of the cellular blastoderm embryo by in situ hybridization. During oogenesis, RecQ5 transcripts are detectable mainly in nurse cells of stage 10 egg chambers and accumulate in the oocyte in stages 11 and 12. (Jeong et al., 2000)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
nucleus inferred from direct assay (Sekelsky et al., 1999)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult fat body, larval trachea, adult female reproductive system, adult male accessory gland. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    155 Larval Midgut    40.1 Larval Hindgut    57.4 Larval Malpighian Tubules    60.1 Larval Fat Body    38.4 Larval Salivary Gland    62.5 Larval Trachea    123.825 Larval Carcass    56.95 Adult Head    87.4 Adult Eye    72.35 Adult Brain    105.2 Adult Thoracic-Abdominal Ganglion    76.4 Adult Crop    70.1 Adult Midgut    44.2 Adult Hindgut    43.6 Adult Malpighian Tubules    65.8 Adult Fat Body    121.9 Adult Salivary Gland    68.1 Adult Heart    94.325 Adult VirginFemale Spermatheca    139.5 Adult InseminatedFemale Spermatheca    116 Adult Ovary    311.4 Adult Testis    28.4 Adult Male Accessory Gland    162.6 Adult Carcass    76 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    155 Larval Midgut    40.1 Larval Hindgut    57.4 Larval Malpighian Tubules    60.1 Larval Fat Body    38.4 Larval Salivary Gland    62.5 Larval Trachea    123.825 Larval Carcass    56.95 Adult Head    87.4 Adult Eye    72.35 Adult Brain    105.2 Adult Thoracic-Abdominal Ganglion    76.4 Adult Crop    70.1 Adult Midgut    44.2 Adult Hindgut    43.6 Adult Malpighian Tubules    65.8 Adult Fat Body    121.9 Adult Salivary Gland    68.1 Adult Heart    94.325 Adult VirginFemale Spermatheca    139.5 Adult InseminatedFemale Spermatheca    116 Adult Ovary    311.4 Adult Testis    28.4 Adult Male Accessory Gland    162.6 Adult Carcass    76 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    155 Larval Midgut    40.1 Larval Hindgut    57.4 Larval Malpighian Tubules    60.1 Larval Fat Body    38.4 Larval Salivary Gland    62.5 Larval Trachea    123.825 Larval Carcass    56.95 Adult Head    87.4 Adult Eye    72.35 Adult Brain    105.2 Adult Thoracic-Abdominal Ganglion    76.4 Adult Crop    70.1 Adult Midgut    44.2 Adult Hindgut    43.6 Adult Malpighian Tubules    65.8 Adult Fat Body    121.9 Adult Salivary Gland    68.1 Adult Heart    94.325 Adult VirginFemale Spermatheca    139.5 Adult InseminatedFemale Spermatheca    116 Adult Ovary    311.4 Adult Testis    28.4 Adult Male Accessory Gland    162.6 Adult Carcass    76 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    155 Larval Midgut    40.1 Larval Hindgut    57.4 Larval Malpighian Tubules    60.1 Larval Fat Body    38.4 Larval Salivary Gland    62.5 Larval Trachea    123.825 Larval Carcass    56.95 Adult Head    87.4 Adult Eye    72.35 Adult Brain    105.2 Adult Thoracic-Abdominal Ganglion    76.4 Adult Crop    70.1 Adult Midgut    44.2 Adult Hindgut    43.6 Adult Malpighian Tubules    65.8 Adult Fat Body    121.9 Adult Salivary Gland    68.1 Adult Heart    94.325 Adult VirginFemale Spermatheca    139.5 Adult InseminatedFemale Spermatheca    116 Adult Ovary    311.4 Adult Testis    28.4 Adult Male Accessory Gland    162.6 Adult Carcass    76 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    155 Larval Midgut    40.1 Larval Hindgut    57.4 Larval Malpighian Tubules    60.1 Larval Fat Body    38.4 Larval Salivary Gland    62.5 Larval Trachea    123.825 Larval Carcass    56.95 Adult Head    87.4 Adult Eye    72.35 Adult Brain    105.2 Adult Thoracic-Abdominal Ganglion    76.4 Adult Crop    70.1 Adult Midgut    44.2 Adult Hindgut    43.6 Adult Malpighian Tubules    65.8 Adult Fat Body    121.9 Adult Salivary Gland    68.1 Adult Heart    94.325 Adult VirginFemale Spermatheca    139.5 Adult InseminatedFemale Spermatheca    116 Adult Ovary    311.4 Adult Testis    28.4 Adult Male Accessory Gland    162.6 Adult Carcass    76 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    155 Larval Midgut    40.1 Larval Hindgut    57.4 Larval Malpighian Tubules    60.1 Larval Fat Body    38.4 Larval Salivary Gland    62.5 Larval Trachea    123.825 Larval Carcass    56.95 Adult Head    87.4 Adult Eye    72.35 Adult Brain    105.2 Adult Thoracic-Abdominal Ganglion    76.4 Adult Crop    70.1 Adult Midgut    44.2 Adult Hindgut    43.6 Adult Malpighian Tubules    65.8 Adult Fat Body    121.9 Adult Salivary Gland    68.1 Adult Heart    94.325 Adult VirginFemale Spermatheca    139.5 Adult InseminatedFemale Spermatheca    116 Adult Ovary    311.4 Adult Testis    28.4 Adult Male Accessory Gland    162.6 Adult Carcass    76 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    155 Larval Midgut    40.1 Larval Hindgut    57.4 Larval Malpighian Tubules    60.1 Larval Fat Body    38.4 Larval Salivary Gland    62.5 Larval Trachea    123.825 Larval Carcass    56.95 Adult Head    87.4 Adult Eye    72.35 Adult Brain    105.2 Adult Thoracic-Abdominal Ganglion    76.4 Adult Crop    70.1 Adult Midgut    44.2 Adult Hindgut    43.6 Adult Malpighian Tubules    65.8 Adult Fat Body    121.9 Adult Salivary Gland    68.1 Adult Heart    94.325 Adult VirginFemale Spermatheca    139.5 Adult InseminatedFemale Spermatheca    116 Adult Ovary    311.4 Adult Testis    28.4 Adult Male Accessory Gland    162.6 Adult Carcass    76 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    155 Larval Midgut    40.1 Larval Hindgut    57.4 Larval Malpighian Tubules    60.1 Larval Fat Body    38.4 Larval Salivary Gland    62.5 Larval Trachea    123.825 Larval Carcass    56.95 Adult Head    87.4 Adult Eye    72.35 Adult Brain    105.2 Adult Thoracic-Abdominal Ganglion    76.4 Adult Crop    70.1 Adult Midgut    44.2 Adult Hindgut    43.6 Adult Malpighian Tubules    65.8 Adult Fat Body    121.9 Adult Salivary Gland    68.1 Adult Heart    94.325 Adult VirginFemale Spermatheca    139.5 Adult InseminatedFemale Spermatheca    116 Adult Ovary    311.4 Adult Testis    28.4 Adult Male Accessory Gland    162.6 Adult Carcass    76 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    87.4   NA  Eye    72.35   NA  Brain    105.2   155  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    76.4   NA  Crop    70.1   40.1  Midgut    44.2   57.4  Hindgut    43.6   60.1  Malpighian Tubules    65.8   38.4  Fat Body    121.9   62.5  Salivary Gland    68.1   NA  Heart    94.325   123.825  Trachea    NA   NA  VirginFemale Spermatheca    139.5   NA  InseminatedFemale Spermatheca    116   NA  Ovary    311.4   NA  Testis    28.4   NA  Male Accessory Gland    162.6   56.95  Carcass    76 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    5 central nervous system, larvae L3    9 central nervous system, pupae P8    6 head, virgin 1-day female    5 head, virgin 4-day female    8 head, virgin 20-day female    4 head, mated 1-day female    6 head, mated 4-day female    6 head, mated 20-day female    4 head, mated 1-day male    7 head, mated 4-day male    7 head, mated 20-day male    8 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    4 digestive system, 4-day adult    5 digestive system, 20-day adult    3 fat body, larvae L3 wandering    1 fat body, white prepupae    3 fat body, pupae P8    2 carcass, larvae L3 wandering    6 carcass, 1-day adult    5 carcass, 4-day adult    7 carcass, 20-day adult    6 ovary, virgin 4-day female    29 ovary, mated 4-day female    27 testis, mated 4-day male    2 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    5 central nervous system, larvae L3    9 central nervous system, pupae P8    6 head, virgin 1-day female    5 head, virgin 4-day female    8 head, virgin 20-day female    4 head, mated 1-day female    6 head, mated 4-day female    6 head, mated 20-day female    4 head, mated 1-day male    7 head, mated 4-day male    7 head, mated 20-day male    8 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    4 digestive system, 4-day adult    5 digestive system, 20-day adult    3 fat body, larvae L3 wandering    1 fat body, white prepupae    3 fat body, pupae P8    2 carcass, larvae L3 wandering    6 carcass, 1-day adult    5 carcass, 4-day adult    7 carcass, 20-day adult    6 ovary, virgin 4-day female  (29) ovary, mated 4-day female  (27) testis, mated 4-day male    2 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    5 central nervous system, larvae L3    9 central nervous system, pupae P8    6 head, virgin 1-day female    5 head, virgin 4-day female    8 head, virgin 20-day female    4 head, mated 1-day female    6 head, mated 4-day female    6 head, mated 20-day female    4 head, mated 1-day male    7 head, mated 4-day male    7 head, mated 20-day male    8 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    4 digestive system, 4-day adult    5 digestive system, 20-day adult    3 fat body, larvae L3 wandering    1 fat body, white prepupae    3 fat body, pupae P8    2 carcass, larvae L3 wandering    6 carcass, 1-day adult    5 carcass, 4-day adult    7 carcass, 20-day adult    6 ovary, virgin 4-day female    29 ovary, mated 4-day female    27 testis, mated 4-day male    2 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    5 central nervous system, larvae L3    9 central nervous system, pupae P8    6 head, virgin 1-day female    5 head, virgin 4-day female    8 head, virgin 20-day female    4 head, mated 1-day female    6 head, mated 4-day female    6 head, mated 20-day female    4 head, mated 1-day male    7 head, mated 4-day male    7 head, mated 20-day male    8 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    4 digestive system, 4-day adult    5 digestive system, 20-day adult    3 fat body, larvae L3 wandering    1 fat body, white prepupae    3 fat body, pupae P8    2 carcass, larvae L3 wandering    6 carcass, 1-day adult    5 carcass, 4-day adult    7 carcass, 20-day adult    6 ovary, virgin 4-day female    29 ovary, mated 4-day female    27 testis, mated 4-day male    2 accessory gland, mated 4-day male    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    5 central nervous system, larvae L3    9 central nervous system, pupae P8    6 head, virgin 1-day female    5 head, virgin 4-day female    8 head, virgin 20-day female    4 head, mated 1-day female    6 head, mated 4-day female    6 head, mated 20-day female    4 head, mated 1-day male    7 head, mated 4-day male    7 head, mated 20-day male    8 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    4 digestive system, 4-day adult    5 digestive system, 20-day adult    3 fat body, larvae L3 wandering    1 fat body, white prepupae    3 fat body, pupae P8    2 carcass, larvae L3 wandering    6 carcass, 1-day adult    5 carcass, 4-day adult    7 carcass, 20-day adult    6 ovary, virgin 4-day female    29 ovary, mated 4-day female    27 testis, mated 4-day male    2 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    5 central nervous system, larvae L3    9 central nervous system, pupae P8    6 head, virgin 1-day female    5 head, virgin 4-day female    8 head, virgin 20-day female    4 head, mated 1-day female    6 head, mated 4-day female    6 head, mated 20-day female    4 head, mated 1-day male    7 head, mated 4-day male    7 head, mated 20-day male    8 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    4 digestive system, 4-day adult    5 digestive system, 20-day adult    3 fat body, larvae L3 wandering    1 fat body, white prepupae    3 fat body, pupae P8    2 carcass, larvae L3 wandering    6 carcass, 1-day adult    5 carcass, 4-day adult    7 carcass, 20-day adult    6 ovary, virgin 4-day female  29 ovary, mated 4-day female  27 testis, mated 4-day male    2 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    5 central nervous system, larvae L3    9 central nervous system, pupae P8    6 head, virgin 1-day female    5 head, virgin 4-day female    8 head, virgin 20-day female    4 head, mated 1-day female    6 head, mated 4-day female    6 head, mated 20-day female    4 head, mated 1-day male    7 head, mated 4-day male    7 head, mated 20-day male    8 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    4 digestive system, 4-day adult    5 digestive system, 20-day adult    3 fat body, larvae L3 wandering    1 fat body, white prepupae    3 fat body, pupae P8    2 carcass, larvae L3 wandering    6 carcass, 1-day adult    5 carcass, 4-day adult    7 carcass, 20-day adult    6 ovary, virgin 4-day female    29 ovary, mated 4-day female    27 testis, mated 4-day male    2 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    5 central nervous system, larvae L3    9 central nervous system, pupae P8    6 head, virgin 1-day female    5 head, virgin 4-day female    8 head, virgin 20-day female    4 head, mated 1-day female    6 head, mated 4-day female    6 head, mated 20-day female    4 head, mated 1-day male    7 head, mated 4-day male    7 head, mated 20-day male    8 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    4 digestive system, 4-day adult    5 digestive system, 20-day adult    3 fat body, larvae L3 wandering    1 fat body, white prepupae    3 fat body, pupae P8    2 carcass, larvae L3 wandering    6 carcass, 1-day adult    5 carcass, 4-day adult    7 carcass, 20-day adult    6 ovary, virgin 4-day female    29 ovary, mated 4-day female    27 testis, mated 4-day male    2 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of very low expression. Peak expression observed within 00-12 and 18-24 hour embryonic stages, during late larval stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    16 embryo 02-04hr    6 embryo 04-06hr    16 embryo 06-08hr    10 embryo 08-10hr    8 embryo 10-12hr    3 embryo 12-14hr    5 embryo 14-16hr    2 embryo 16-18hr    3 embryo 18-20hr    2 embryo 20-22hr    4 embryo 22-24hr    7 larva L1    2 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    6 white prepupae new    4 white prepupae 12hr    4 white prepupae 24hr    4 pupae 2d postWPP    3 pupae 3d postWPP    2 pupae 4d postWPP    1 adult male 01day    3 adult male 05day    3 adult male 30day    2 adult female 01day    4 adult female 05day    13 adult female 30day    10 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    16 embryo 02-04hr    6 embryo 04-06hr    16 embryo 06-08hr    10 embryo 08-10hr    8 embryo 10-12hr    3 embryo 12-14hr    5 embryo 14-16hr    2 embryo 16-18hr    3 embryo 18-20hr    2 embryo 20-22hr    4 embryo 22-24hr    7 larva L1    2 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    6 white prepupae new    4 white prepupae 12hr    4 white prepupae 24hr    4 pupae 2d postWPP    3 pupae 3d postWPP    2 pupae 4d postWPP    1 adult male 01day    3 adult male 05day    3 adult male 30day    2 adult female 01day    4 adult female 05day    13 adult female 30day    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    16 embryo 02-04hr    6 embryo 04-06hr    16 embryo 06-08hr    10 embryo 08-10hr    8 embryo 10-12hr    3 embryo 12-14hr    5 embryo 14-16hr    2 embryo 16-18hr    3 embryo 18-20hr    2 embryo 20-22hr    4 embryo 22-24hr    7 larva L1    2 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    6 white prepupae new    4 white prepupae 12hr    4 white prepupae 24hr    4 pupae 2d postWPP    3 pupae 3d postWPP    2 pupae 4d postWPP    1 adult male 01day    3 adult male 05day    3 adult male 30day    2 adult female 01day    4 adult female 05day    13 adult female 30day    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    16 embryo 02-04hr    6 embryo 04-06hr    16 embryo 06-08hr    10 embryo 08-10hr    8 embryo 10-12hr    3 embryo 12-14hr    5 embryo 14-16hr    2 embryo 16-18hr    3 embryo 18-20hr    2 embryo 20-22hr    4 embryo 22-24hr    7 larva L1    2 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    6 white prepupae new    4 white prepupae 12hr    4 white prepupae 24hr    4 pupae 2d postWPP    3 pupae 3d postWPP    2 pupae 4d postWPP    1 adult male 01day    3 adult male 05day    3 adult male 30day    2 adult female 01day    4 adult female 05day    13 adult female 30day    10 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    16 embryo 02-04hr    6 embryo 04-06hr    16 embryo 06-08hr    10 embryo 08-10hr    8 embryo 10-12hr    3 embryo 12-14hr    5 embryo 14-16hr    2 embryo 16-18hr    3 embryo 18-20hr    2 embryo 20-22hr    4 embryo 22-24hr    7 larva L1    2 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    6 white prepupae new    4 white prepupae 12hr    4 white prepupae 24hr    4 pupae 2d postWPP    3 pupae 3d postWPP    2 pupae 4d postWPP    1 adult male 01day    3 adult male 05day    3 adult male 30day    2 adult female 01day    4 adult female 05day    13 adult female 30day    10 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    16 embryo 02-04hr    6 embryo 04-06hr    16 embryo 06-08hr    10 embryo 08-10hr    8 embryo 10-12hr    3 embryo 12-14hr    5 embryo 14-16hr    2 embryo 16-18hr    3 embryo 18-20hr    2 embryo 20-22hr    4 embryo 22-24hr    7 larva L1    2 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    6 white prepupae new    4 white prepupae 12hr    4 white prepupae 24hr    4 pupae 2d postWPP    3 pupae 3d postWPP    2 pupae 4d postWPP    1 adult male 01day    3 adult male 05day    3 adult male 30day    2 adult female 01day    4 adult female 05day    13 adult female 30day    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    16 embryo 02-04hr    6 embryo 04-06hr    16 embryo 06-08hr    10 embryo 08-10hr    8 embryo 10-12hr    3 embryo 12-14hr    5 embryo 14-16hr    2 embryo 16-18hr    3 embryo 18-20hr    2 embryo 20-22hr    4 embryo 22-24hr    7 larva L1    2 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    6 white prepupae new    4 white prepupae 12hr    4 white prepupae 24hr    4 pupae 2d postWPP    3 pupae 3d postWPP    2 pupae 4d postWPP    1 adult male 01day    3 adult male 05day    3 adult male 30day    2 adult female 01day    4 adult female 05day    13 adult female 30day    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    16 embryo 02-04hr    6 embryo 04-06hr    16 embryo 06-08hr    10 embryo 08-10hr    8 embryo 10-12hr    3 embryo 12-14hr    5 embryo 14-16hr    2 embryo 16-18hr    3 embryo 18-20hr    2 embryo 20-22hr    4 embryo 22-24hr    7 larva L1    2 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    6 white prepupae new    4 white prepupae 12hr    4 white prepupae 24hr    4 pupae 2d postWPP    3 pupae 3d postWPP    2 pupae 4d postWPP    1 adult male 01day    3 adult male 05day    3 adult male 30day    2 adult female 01day    4 adult female 05day    13 adult female 30day    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    19 Schneider line 2 Sg4    5 embryonic 1182-4H    10 embryonic GM2    22 embryonic Kc167    22 embryonic S1    12 embryonic S3    17 leg disc CME L1    6 wing disc CME-W2    12 wing disc ML-DmD8    9 wing disc ML-DmD9    6 wing disc ML-DmD16-c3    10 wing disc ML-DmD21    5 wing disc ML-DmD32    6 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    6 antennal disc ML-DmD20-c5    6 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    18 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    20 ovary fGS/OSS    28 ovary OSC    28 ovary OSS    22 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    19 Schneider line 2 Sg4    5 embryonic 1182-4H    10 embryonic GM2    22 embryonic Kc167    22 embryonic S1    12 embryonic S3    17 leg disc CME L1    6 wing disc CME-W2    12 wing disc ML-DmD8    9 wing disc ML-DmD9    6 wing disc ML-DmD16-c3    10 wing disc ML-DmD21    5 wing disc ML-DmD32    6 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    6 antennal disc ML-DmD20-c5    6 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    18 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    20 ovary fGS/OSS  (28) ovary OSC  (28) ovary OSS    22 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    19 Schneider line 2 Sg4    5 embryonic 1182-4H    10 embryonic GM2    22 embryonic Kc167    22 embryonic S1    12 embryonic S3    17 leg disc CME L1    6 wing disc CME-W2    12 wing disc ML-DmD8    9 wing disc ML-DmD9    6 wing disc ML-DmD16-c3    10 wing disc ML-DmD21    5 wing disc ML-DmD32    6 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    6 antennal disc ML-DmD20-c5    6 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    18 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    20 ovary fGS/OSS    28 ovary OSC    28 ovary OSS    22 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    19 Schneider line 2 Sg4    5 embryonic 1182-4H    10 embryonic GM2    22 embryonic Kc167    22 embryonic S1    12 embryonic S3    17 leg disc CME L1    6 wing disc CME-W2    12 wing disc ML-DmD8    9 wing disc ML-DmD9    6 wing disc ML-DmD16-c3    10 wing disc ML-DmD21    5 wing disc ML-DmD32    6 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    6 antennal disc ML-DmD20-c5    6 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    18 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    20 ovary fGS/OSS    28 ovary OSC    28 ovary OSS    22 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    19 Schneider line 2 Sg4    5 embryonic 1182-4H    10 embryonic GM2    22 embryonic Kc167    22 embryonic S1    12 embryonic S3    17 leg disc CME L1    6 wing disc CME-W2    12 wing disc ML-DmD8    9 wing disc ML-DmD9    6 wing disc ML-DmD16-c3    10 wing disc ML-DmD21    5 wing disc ML-DmD32    6 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    6 antennal disc ML-DmD20-c5    6 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    18 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    20 ovary fGS/OSS    28 ovary OSC    28 ovary OSS    22 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    19 Schneider line 2 Sg4    5 embryonic 1182-4H    10 embryonic GM2    22 embryonic Kc167    22 embryonic S1    12 embryonic S3    17 leg disc CME L1    6 wing disc CME-W2    12 wing disc ML-DmD8    9 wing disc ML-DmD9    6 wing disc ML-DmD16-c3    10 wing disc ML-DmD21    5 wing disc ML-DmD32    6 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    6 antennal disc ML-DmD20-c5    6 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    18 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    20 ovary fGS/OSS  28 ovary OSC  28 ovary OSS    22 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    19 Schneider line 2 Sg4    5 embryonic 1182-4H    10 embryonic GM2    22 embryonic Kc167    22 embryonic S1    12 embryonic S3    17 leg disc CME L1    6 wing disc CME-W2    12 wing disc ML-DmD8    9 wing disc ML-DmD9    6 wing disc ML-DmD16-c3    10 wing disc ML-DmD21    5 wing disc ML-DmD32    6 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    6 antennal disc ML-DmD20-c5    6 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    18 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    20 ovary fGS/OSS    28 ovary OSC    28 ovary OSS    22 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    19 Schneider line 2 Sg4    5 embryonic 1182-4H    10 embryonic GM2    22 embryonic Kc167    22 embryonic S1    12 embryonic S3    17 leg disc CME L1    6 wing disc CME-W2    12 wing disc ML-DmD8    9 wing disc ML-DmD9    6 wing disc ML-DmD16-c3    10 wing disc ML-DmD21    5 wing disc ML-DmD32    6 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    6 antennal disc ML-DmD20-c5    6 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    18 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    20 ovary fGS/OSS    28 ovary OSC    28 ovary OSS    22 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    2 heat shock, 4-day adult    6 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    27 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    49 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    24 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    2 heat shock, 4-day adult    6 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult  (27) Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult  (49) Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    24 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    2 heat shock, 4-day adult    6 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    27 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    49 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    24 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    2 heat shock, 4-day adult    6 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    27 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    49 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    24 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    2 heat shock, 4-day adult    6 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    27 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    49 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    24 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    2 heat shock, 4-day adult    6 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult  27 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult  (49) Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    24 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    2 heat shock, 4-day adult    6 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    27 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    49 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    24 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    2 heat shock, 4-day adult    6 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    27 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    49 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    24 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    18 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_13 mE1_20_mRNA_expression_cluster_06
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0027375 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4879-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable RecQ55 RecQ5D1 RecQ5D2 viable, with Scer\GAL4pnr-MD237 RecQ5GD5051 Sterility Allele fertile RecQ55 RecQ5D1 RecQ5D2 Other Phenotypes Allele developmental rate defective RecQ55 DNA repair defective RecQ55 mitotic cell cycle defective | maternal effect RecQ5D1 RecQ5D2 mitotic cell cycle defective | maternal effect (with RecQ5D1) RecQ5D2 mitotic cell cycle defective | maternal effect (with RecQ5D2) RecQ5D1 radiation sensitive (with Df(3L)fz-D21) RecQ5D1 radiation sensitive | third instar larval stage RecQ55 Phenotype manifest in Allele centrosome | maternal effect RecQ5D1 centrosome | maternal effect (with RecQ5D1) RecQ5D2 centrosome | maternal effect (with RecQ5D2) RecQ5D1 embryo | maternal effect RecQ5D1 RecQ5D2 embryo | maternal effect (with RecQ5D1) RecQ5D2 embryo | maternal effect (with RecQ5D2) RecQ5D1 eye, with Scer\GAL4GMR.PF RecQ5Scer\UAS.cNa interommatidial bristle, with Scer\GAL4GMR.PF RecQ5Scer\UAS.cNa nucleus | maternal effect RecQ5D1 RecQ5D2 nucleus | maternal effect (with RecQ5D1) RecQ5D2 nucleus | maternal effect (with RecQ5D2) RecQ5D1 ommatidial precursor cluster, with Scer\GAL4GMR.PF RecQ5Scer\UAS.cNa
Classical Alleles ( 8 )
For All Classical Alleles Show
Allele of RecQ5 Class Mutagen Stocks Known lesion RecQ5BG01967 P-element activity 2 Yes RecQ5CB-6322-3 1 -- RecQ5f01578 piggyBac transposase 1 -- RecQ55 recombination FLPase SCEI endonuclease I-CreI endonuclease ends-in gene targeting 0 Yes RecQ5D1 P-element activity 0 Yes RecQ5D2 P-element activity 0 Yes RecQ5ex15 Delta2-3 0 Yes RecQ5f06782 piggyBac transposase 0 --
Alleles Carried on Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Allele of RecQ5 Class Mutagen Stocks Known lesion RecQ5GD5051 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes RecQ5HMS00466 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes RecQ5NIG.4879R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes RecQ5Scer\UAS.cNa 0 Yes RecQ5Scer\UAS.cNb in vitro construct - regulatory fusion 0 Yes RecQ5Ubi-p63E.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)Exel6124 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD5051} NA P{NIG.4879R} NA P{TRiP.HMS00466} NA P{UAS-RecQ5.N} NA P{UAS-RecQ5.Nb} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{GT1}RecQ5BG01967 NA P{RS3}RecQ5CB-6322-3 NA PBac{WH}RecQ5f01578 NA PBac{WH}RecQ5f06782 NA insertion of mobile activating element P{GSV1}EP-1013EP-1013 NA
Gene Ontology: Function, Process & Cellular Component ( 15 unique terms )
Terms Based on Experimental Evidence ( 9 terms )
Molecular Function
CV term Evidence References
GTPase activity inferred from direct assay (Kawasaki et al., 2002) GTP binding inferred from direct assay (Kawasaki et al., 2002) single-stranded DNA-dependent ATP-dependent DNA helicase activity inferred from direct assay (Ozsoy et al., 2001, Kawasaki et al., 2002)
Biological Process
CV term Evidence References
double-strand break repair via single-strand annealing inferred from mutant phenotype (Chen et al., 2010) negative regulation of mitotic cell cycle inferred from mutant phenotype (Nakayama et al., 2006) regulation of mitotic anaphase inferred from direct assay (Sakurai et al., 2011) response to DNA damage stimulus inferred from direct assay (Nakayama et al., 2009) inferred from mutant phenotype (Nakayama et al., 2006) response to X-ray inferred from direct assay (Nakayama et al., 2009)
Cellular Component
CV term Evidence References
nucleus inferred from direct assay (Sekelsky et al., 1999)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR001650, InterPro:IPR011545 (FlyBase Curators et al., 2004-) ATP-dependent DNA helicase activity inferred from sequence or structural similarity (Kawasaki et al., 1999) inferred from sequence or structural similarity with UniProtKB:O94762 (FlyBase, 1992-) DNA helicase activity inferred from sequence or structural similarity (Jeong, 1999.8.13) inferred from sequence or structural similarity with human RECQL5 (Sekelsky et al., 2000) helicase activity inferred from sequence or structural similarity (Lasko, 2000) nucleic acid binding inferred from electronic annotation with InterPro:IPR001650, InterPro:IPR011545 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
DNA recombination inferred from electronic annotation with InterPro:IPR004589 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions RecQ5 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 64924 DroID - A comprehensive database of gene and protein interactions. • FBgn0027375 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39594
Orthologs
OrthoDB Orthologs (42) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6MGSSR Dipteran inclusive ortholog search EOG615GND Insect inclusive ortholog search EOG6ZGN7G Arthropod inclusive ortholog search EOG63J9KT Metazoa inclusive ortholog search EOG6MH514
Orthologs in Drosophila Species (EOG6MGSSR)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\RecQ5     Drosophila simulans   Dsim\GD12613 Y   Drosophila sechellia   Dsec\GM24539 Y   Drosophila erecta   Dere\GG13718 Y   Drosophila yakuba   Dyak\GE20014 Y   Drosophila ananassae   Dana\GF25191 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA18497 Y   Drosophila persimilis   Dper\GL20982 Y   Drosophila willistoni   Dwil\GK10589 Y   Drosophila virilis   Dvir\GJ11681 Y   Drosophila mojavensis   Dmoj\GI13816 Y   Drosophila grimshawi   Dgri\GH16802 Y   Drosophila grimshawi   Dgri\GH24741
Orthologs in non-Drosophila Dipterans (EOG615GND)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL005597   Anopheles gambiae Malaria mosquito  Agam\AGAP001255   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ006071
Orthologs in non-Dipteran Insects (EOG6ZGN7G)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB51984   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG021423   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH25073   Atta cephalotes Leafcutter ant  Acep\ACEP19647   Camponotus floridanus Florida carpenter ant  Cflo\CFLO23166   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL23654   Linepithema humile Argentine ant  Lhum\LH17377   Pogonomyrmex barbatus Red harvester ant  Pbar\PB14427   Solenopsis invicta Red fire ant  Sinv\SINV17002   Acyrthosiphon pisum Pea aphid  Apim\ACYPI004316   Acyrthosiphon pisum Pea aphid  Apim\ACYPI004823   Bombyx mori Silkmoth  Bmor\BGIBMGA010637   Pediculus humanus Human body louse  Phum\PHUM178540   Tribolium castaneum Red flour beetle  Tcas\RecQ5
Orthologs in non-Insect Arthropods (EOG63J9KT)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_347586   Ixodes scapularis Deer tick  Isca\ISCW016114
Orthologs in non-Arthropod Metazoa (EOG6MH514)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\rcq-5   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_010556gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_004597gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_000741gn   Danio rerio Zebrafish  Drer\ENSDARG00000059556   Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000032721   Gallus gallus Domestic chicken  Ggal\ENSGALG00000002424   Mus musculus House mouse  Mmus\Recql5   Rattus norvegicus Norway rat  Rnor\Recql5   Homo sapiens Human  Hsap\RECQL5
Human Orthologs (1)
Gene OMIM HGNC Hsap\RECQL5
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD12613 Drosophila sechellia Dsec\GM24539 Drosophila erecta Dere\GG13718 Drosophila yakuba Dyak\GE20014 Drosophila ananassae Dana\GF25191 Drosophila pseudoobscura pseudoobscura Dpse\GA18497 Drosophila persimilis Dper\GL20982 Drosophila willistoni Dwil\GK10589 Drosophila virilis Dvir\GJ11681 Drosophila mojavensis Dmoj\GI13816 Drosophila grimshawi Dgri\GH16802
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	12615 w1118; P{GT1}RecQ5BG01967 32466 y1 sc* v1; P{TRiP.HMS00466}attP2
Harvard	- PBac{WH}RecQ5f01578
Kyoto	108884 w1118; P{GT1}RecQ5BG01967 124047 w1118; P{RS3}RecQ5CB-6322-3
VDRC	v13363 w1118; P{GD5051}v13363
Genomic Clones ( 1 )
	BACR11B23 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 41 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH01404 RE21659
Other clones	AF171784
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RE70978 SD23508
Other clones	1270 60736 62654 122632 160952 160960 214445.45 CK01.56C.F2 CK01.64A.C8 Dmel_dig_011339_0581_2327 EC051079 EC052604 EC055119 EC056379 EC056430 EK064641 EK122318 EK174042 EK186930 EK187937 EK265030 EK265046 EP15958 LD21474 RP004021412 RP004047924 RP004062533 RP004087571 RP004194438 RP004205987 RP004221935 RP004238040 RP004239364 RP004241916 RP004537136 RP004543574
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0027375 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39594
Antibody Information
	polyclonal (Jeong et al., 2000)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: RecQ5 CG4879 (Bayraktaroglu, 1999.11)
Source for database merge of	Source for merge of: RecQ5 anon-EST:Posey293 (Bayraktaroglu, 2000.11.2)
Additional comments
Other Comments
	DNA damage caused by methyl-methanesulfonate (MMS) increases the level of RecQ5 in S2 cells. This overexpression perturbs cell-cycle progression under the condition of DNA damage. (Nakayama et al., 2006) The RecQ5 protein is a ssDNA-stimulated ATPase and an ATP-dependent DNA helicase. It is also a ssDNA-dependent GTPase, and GTP binding stimulates the ATP-dependent DNA helicase activity of the protein. (Kawasaki et al., 2002) RecQ5 expression is developmentally regulated and the DNA helicase activity of RecQ5 might be involved in the DNA metabolism of early embryos. (Jeong et al., 2000) Isolated a cDNA clone, homologous to E.coli recQ, from a D.melanogaster library. (Jeong et al., 1998)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079346 NM_168591 NM_001014584 RefSeq (Proteins) • NP_524070 NP_729983 NP_001014584 DDBJ / EMBL / GenBank • AA735537 AAD43051 AAD43052 AAD43053 AAF49724 AAF49724.2 AAL13481 AAN11801 AAN11801.1 AAX52745 AB031086 AB031087 AF134239 AF171784 AI062257 AI455153 AW940040 AY058252 BAA88312 BAA88313 BH011444 BH011445 CZ484043 CZ489506 Entrez Gene - A searchable database of RefSeq genes. • 39594 UniProtKB/TrEMBL • Q7YZ98 Q9U5E0 Q9UA31 Q9UA32 Q9V433 Q9Y1H2 Q59E27 Q95U81
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Helicase, C-terminal (IPR001650) DNA helicase, ATP-dependent, RecQ type (IPR004589) DNA/RNA helicase, DEAD/DEAH box type, N-terminal (IPR011545) Helicase, superfamily 1/2, ATP-binding domain (IPR014001) P-loop containing nucleoside triphosphate hydrolase (IPR027417) Winged helix-turn-helix DNA-binding domain (IPR011991)
Linkouts
	BioGRID - A database of protein and genetic interactions • 64924 DroID - A comprehensive database of gene and protein interactions. • FBgn0027375 DRSC - Results from RNAi screens. • FBgn0027375 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0027375 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4879-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0027375 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39594 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39594 modMine - Data generated by the modENCODE project. • FBgn0027375
Synonyms & Secondary IDs ( 15 )
Reported As
Symbol Synonym	anon-EST:Posey293   CG4879 (Molnar et al., 2006, Ni et al., 2010.12.1) DmRECQ5 (Ozsoy et al., 2003) Dm RECQ5/QE (Kawasaki et al., 2003) dmRecQ5b (Machwe et al., 2005) DQ1 (Kawasaki and Shibata, 2000, Jeong et al., 1998) Dq1 (Kawasaki et al., 1999) dRecQ5 (Chen et al., 2010) Q1 (Jeong, 1998.3.12, ) RECQ5 (Ozsoy et al., 2001, Nakayama et al., 2006) RecQ5 (Nakayama et al., 2006, Molnar et al., 2006, Bakal et al., 2007, Wasbrough et al., 2010, Nakayama et al., 2009, Sakurai et al., 2011, Maruyama et al., 2012, Japanese National Institute of Genetics, 2012.5.21) RECQ5/QE (Kawasaki et al., 2002, Nakayama et al., 2006) RECQE (Jeong et al., 2000, Kawasaki and Shibata, 2000, Jeong, 1999.8.13, Jeong, 1999.8.13, )
Name Synonym	Drosophila homolog of RecQ (Jeong et al., 1998) homolog of RecQ (Jeong et al., 1998)
Secondary FlyBase IDs
	FBgn0024312 FBgn0027689
References ( 47 )
Generate a list of	All references relating to this gene ( 47 )
List References by type	Research paper  ( 17 ) Supplementary material  ( 6 ) Personal communication to FlyBase  ( 9 ) Abstract  ( 5 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 3 ) Stock list  ( 1 ) Curated genome annotation  ( 3 )
Recent research papers ( 2 )
	Maruyama et al., 2012, Biol. Pharmaceut. Bull. 35(11): 2017--2022 RecQ5 Interacts with Rad51 and Is Involved in Resistance of Drosophila to Cisplatin Treatment. [FBrf0219869] Sakurai et al., 2011, FEBS Lett. 585(12): 1923--1928 Anaphase DNA bridges induced by lack of RecQ5 in Drosophila syncytial embryos. [FBrf0213874] Show all research papers ...