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Gene Dmel\MRG15

General Information
Symbol	Dmel\MRG15	Species	D. melanogaster
Name	MRG15	Annotation symbol	CG6363
Feature type	protein_coding_gene	FlyBase ID	FBgn0027378
Gene Model Status	Current	Stock availability	5 publicly available
Also Known As	dMrg15, DmMRG15
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	88E11-88E11	Sequence location	3R:11,102,162..11,103,831 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene MRG15 is referred to in FlyBase by the symbol Dmel\MRG15 (CG6363, FBgn0027378). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: methylated histone residue binding. There is experimental evidence that it is involved in the biological process: histone exchange; histone acetylation; chromatin silencing. 10 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Chromo domain-like; Chromo domain/shadow; MRG; MRG domain; RNA binding activity-knot of a chromodomain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, adult crop, larval/adult hindgut, larval/adult Malpighian tubules, larval fat body, larval salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1626620_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of MRG15. Gene sequence location is 3R:11102162..11103831.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 88E11-88E11   Limits computationally determined from genome sequence between P{lacW}Hsc70-4L3929 and P{lacW}MRG15j6A3
Experimentally Determined Cytological Location
Cytogenetic map Notes References 88E9-88E12     (Bertram, 1999.5.17) 88E11-88E12   (determined by in situ hybridisation)   (Spradling et al., 1999) 88E11-88E12     (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\MRG15 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.46 Gene model reviewed during 5.47
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) MRG15-RA FBtr0083125  NM_142185   1496   424 MRG15-RB FBtr0333921  NM_001275659   1511   429
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein MRG15-PA   FBpp0082579   47.2   424   8.38     NP_650442   AAF55161 MRG15-PB   FBpp0306049   47.7   429   8.38     NP_001262588   AGB95969
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Chromo domain/shadow (IPR000953) MRG (IPR008676) Chromo domain-like (IPR016197) RNA binding activity-knot of a chromodomain (IPR025995) MRG domain (IPR026541)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA439558   AA539729   AA817270   AA940732   AA941284   AA951428   AE014297 AAF55161   AF152245 AAD38047   AE014297 AGB95969   AI238997   AI403436   AI519368   AI533362   AI546238   AQ026327   AW942657   AY051679 AAK93103   BG638308   BI169953   BI227795   BI364885   BI365099   BI365224   BI367206   BI375140   BI375707   BI630703   BI638560   CO156297   CO329544   EC078833   EC201408   EV580513   GH747921   GH748072   GH749097   GH749345   GH749463   GH750204   GH750538   GH751456   GH754964   GH756672   GH772986   GH774366   GH774645   GH775348   GH778052   GH780035   GH780265   GH781978   GH785549   GH785611   GH786029   GH790711   GH791285   GH791496   GH793258   GH794390   GH798879   GH799602   GH800417   GH802450   GH802673   GH805461   GH808710   GH815412   GH817188   GH818120   GH821742   GH821992   GH822472   GH822687   GH823539   GH824099   GH825181   GH829492   GH830549   GH831192   GH832554   GH834284   GH834971   GH835905   GH835963   GH836150   GH844083   GH844278   GH845214   GH847171   GH848363   GH850505   GH856782   GH856963   GH859043   GH860796   GH860812   GH860975   GH863102   GH863936   GH865092   GH867629   GH867938   GH869422   GH869712   GH874551   GH876607   GH879355   GH883302   GH883532   GH884283   GH884594   GH885098   GH887274   GH892449   GH896766   GH897671   GH898082   GH899734   GH902241   GH902249   GH902331   GH903228   GH907100   GH907604   GH907746   GH908070   GH912388   GH912469   GH913843   GH914526   GH916434   GH917203   GH918264   GH918387   GH918424   GH920219   GH924464   GH925002   GH928437   GH929365   GH930869
UniProtKB/Swiss-Prot	Q9Y0I1
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | ubiquitous   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 11 -- 12   central brain primordium   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic brain   (Fisher et al., 2012) embryonic/larval nervous system   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
histone acetyltransferase complex inferred from physical interaction with pont (Kusch et al., 2004) nucleus inferred from direct assay (Kusch et al., 2004)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, adult crop, larval/adult hindgut, larval/adult Malpighian tubules, larval fat body, larval salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    223.625 Larval Midgut    87.1 Larval Hindgut    115.6 Larval Malpighian Tubules    116.7 Larval Fat Body    110.1 Larval Salivary Gland    163.7 Larval Trachea    173.9 Larval Carcass    139.6 Adult Head    99.5 Adult Eye    103.875 Adult Brain    133.2 Adult Thoracic-Abdominal Ganglion    106.7 Adult Crop    113.1 Adult Midgut    99.9 Adult Hindgut    109 Adult Malpighian Tubules    104.6 Adult Fat Body    93.9 Adult Salivary Gland    97 Adult Heart    91.925 Adult VirginFemale Spermatheca    112.6 Adult InseminatedFemale Spermatheca    135.9 Adult Ovary    238.4 Adult Testis    42.9 Adult Male Accessory Gland    128.3 Adult Carcass    114.5 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    223.625 Larval Midgut    87.1 Larval Hindgut    115.6 Larval Malpighian Tubules    116.7 Larval Fat Body    110.1 Larval Salivary Gland    163.7 Larval Trachea    173.9 Larval Carcass    139.6 Adult Head    99.5 Adult Eye    103.875 Adult Brain    133.2 Adult Thoracic-Abdominal Ganglion    106.7 Adult Crop    113.1 Adult Midgut    99.9 Adult Hindgut    109 Adult Malpighian Tubules    104.6 Adult Fat Body    93.9 Adult Salivary Gland    97 Adult Heart    91.925 Adult VirginFemale Spermatheca    112.6 Adult InseminatedFemale Spermatheca    135.9 Adult Ovary    238.4 Adult Testis    42.9 Adult Male Accessory Gland    128.3 Adult Carcass    114.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    223.625 Larval Midgut    87.1 Larval Hindgut    115.6 Larval Malpighian Tubules    116.7 Larval Fat Body    110.1 Larval Salivary Gland    163.7 Larval Trachea    173.9 Larval Carcass    139.6 Adult Head    99.5 Adult Eye    103.875 Adult Brain    133.2 Adult Thoracic-Abdominal Ganglion    106.7 Adult Crop    113.1 Adult Midgut    99.9 Adult Hindgut    109 Adult Malpighian Tubules    104.6 Adult Fat Body    93.9 Adult Salivary Gland    97 Adult Heart    91.925 Adult VirginFemale Spermatheca    112.6 Adult InseminatedFemale Spermatheca    135.9 Adult Ovary    238.4 Adult Testis    42.9 Adult Male Accessory Gland    128.3 Adult Carcass    114.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    223.625 Larval Midgut    87.1 Larval Hindgut    115.6 Larval Malpighian Tubules    116.7 Larval Fat Body    110.1 Larval Salivary Gland    163.7 Larval Trachea    173.9 Larval Carcass    139.6 Adult Head    99.5 Adult Eye    103.875 Adult Brain    133.2 Adult Thoracic-Abdominal Ganglion    106.7 Adult Crop    113.1 Adult Midgut    99.9 Adult Hindgut    109 Adult Malpighian Tubules    104.6 Adult Fat Body    93.9 Adult Salivary Gland    97 Adult Heart    91.925 Adult VirginFemale Spermatheca    112.6 Adult InseminatedFemale Spermatheca    135.9 Adult Ovary    238.4 Adult Testis    42.9 Adult Male Accessory Gland    128.3 Adult Carcass    114.5 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    223.625 Larval Midgut    87.1 Larval Hindgut    115.6 Larval Malpighian Tubules    116.7 Larval Fat Body    110.1 Larval Salivary Gland    163.7 Larval Trachea    173.9 Larval Carcass    139.6 Adult Head    99.5 Adult Eye    103.875 Adult Brain    133.2 Adult Thoracic-Abdominal Ganglion    106.7 Adult Crop    113.1 Adult Midgut    99.9 Adult Hindgut    109 Adult Malpighian Tubules    104.6 Adult Fat Body    93.9 Adult Salivary Gland    97 Adult Heart    91.925 Adult VirginFemale Spermatheca    112.6 Adult InseminatedFemale Spermatheca    135.9 Adult Ovary    238.4 Adult Testis    42.9 Adult Male Accessory Gland    128.3 Adult Carcass    114.5 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    223.625 Larval Midgut    87.1 Larval Hindgut    115.6 Larval Malpighian Tubules    116.7 Larval Fat Body    110.1 Larval Salivary Gland    163.7 Larval Trachea    173.9 Larval Carcass    139.6 Adult Head    99.5 Adult Eye    103.875 Adult Brain    133.2 Adult Thoracic-Abdominal Ganglion    106.7 Adult Crop    113.1 Adult Midgut    99.9 Adult Hindgut    109 Adult Malpighian Tubules    104.6 Adult Fat Body    93.9 Adult Salivary Gland    97 Adult Heart    91.925 Adult VirginFemale Spermatheca    112.6 Adult InseminatedFemale Spermatheca    135.9 Adult Ovary    238.4 Adult Testis    42.9 Adult Male Accessory Gland    128.3 Adult Carcass    114.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    223.625 Larval Midgut    87.1 Larval Hindgut    115.6 Larval Malpighian Tubules    116.7 Larval Fat Body    110.1 Larval Salivary Gland    163.7 Larval Trachea    173.9 Larval Carcass    139.6 Adult Head    99.5 Adult Eye    103.875 Adult Brain    133.2 Adult Thoracic-Abdominal Ganglion    106.7 Adult Crop    113.1 Adult Midgut    99.9 Adult Hindgut    109 Adult Malpighian Tubules    104.6 Adult Fat Body    93.9 Adult Salivary Gland    97 Adult Heart    91.925 Adult VirginFemale Spermatheca    112.6 Adult InseminatedFemale Spermatheca    135.9 Adult Ovary    238.4 Adult Testis    42.9 Adult Male Accessory Gland    128.3 Adult Carcass    114.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    223.625 Larval Midgut    87.1 Larval Hindgut    115.6 Larval Malpighian Tubules    116.7 Larval Fat Body    110.1 Larval Salivary Gland    163.7 Larval Trachea    173.9 Larval Carcass    139.6 Adult Head    99.5 Adult Eye    103.875 Adult Brain    133.2 Adult Thoracic-Abdominal Ganglion    106.7 Adult Crop    113.1 Adult Midgut    99.9 Adult Hindgut    109 Adult Malpighian Tubules    104.6 Adult Fat Body    93.9 Adult Salivary Gland    97 Adult Heart    91.925 Adult VirginFemale Spermatheca    112.6 Adult InseminatedFemale Spermatheca    135.9 Adult Ovary    238.4 Adult Testis    42.9 Adult Male Accessory Gland    128.3 Adult Carcass    114.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    99.5   NA  Eye    103.875   NA  Brain    133.2   223.625  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    106.7   NA  Crop    113.1   87.1  Midgut    99.9   115.6  Hindgut    109   116.7  Malpighian Tubules    104.6   110.1  Fat Body    93.9   163.7  Salivary Gland    97   NA  Heart    91.925   173.9  Trachea    NA   NA  VirginFemale Spermatheca    112.6   NA  InseminatedFemale Spermatheca    135.9   NA  Ovary    238.4   NA  Testis    42.9   NA  Male Accessory Gland    128.3   139.6  Carcass    114.5 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    50 central nervous system, larvae L3    61 central nervous system, pupae P8    16 head, virgin 1-day female    15 head, virgin 4-day female    15 head, virgin 20-day female    15 head, mated 1-day female    16 head, mated 4-day female    11 head, mated 20-day female    14 head, mated 1-day male    17 head, mated 4-day male    18 head, mated 20-day male    21 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    20 digestive system, 1-day adult    13 digestive system, 4-day adult    12 digestive system, 20-day adult    12 fat body, larvae L3 wandering    13 fat body, white prepupae    17 fat body, pupae P8    15 carcass, larvae L3 wandering    36 carcass, 1-day adult    16 carcass, 4-day adult    17 carcass, 20-day adult    18 ovary, virgin 4-day female    66 ovary, mated 4-day female    72 testis, mated 4-day male    28 accessory gland, mated 4-day male    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (50) central nervous system, larvae L3  (61) central nervous system, pupae P8    16 head, virgin 1-day female    15 head, virgin 4-day female    15 head, virgin 20-day female    15 head, mated 1-day female    16 head, mated 4-day female    11 head, mated 20-day female    14 head, mated 1-day male    17 head, mated 4-day male    18 head, mated 20-day male    21 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    20 digestive system, 1-day adult    13 digestive system, 4-day adult    12 digestive system, 20-day adult    12 fat body, larvae L3 wandering    13 fat body, white prepupae    17 fat body, pupae P8    15 carcass, larvae L3 wandering  (36) carcass, 1-day adult    16 carcass, 4-day adult    17 carcass, 20-day adult    18 ovary, virgin 4-day female  (66) ovary, mated 4-day female  (72) testis, mated 4-day male  (28) accessory gland, mated 4-day male    19 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    50 central nervous system, larvae L3    61 central nervous system, pupae P8    16 head, virgin 1-day female    15 head, virgin 4-day female    15 head, virgin 20-day female    15 head, mated 1-day female    16 head, mated 4-day female    11 head, mated 20-day female    14 head, mated 1-day male    17 head, mated 4-day male    18 head, mated 20-day male    21 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    20 digestive system, 1-day adult    13 digestive system, 4-day adult    12 digestive system, 20-day adult    12 fat body, larvae L3 wandering    13 fat body, white prepupae    17 fat body, pupae P8    15 carcass, larvae L3 wandering    36 carcass, 1-day adult    16 carcass, 4-day adult    17 carcass, 20-day adult    18 ovary, virgin 4-day female    66 ovary, mated 4-day female    72 testis, mated 4-day male    28 accessory gland, mated 4-day male    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    50 central nervous system, larvae L3    61 central nervous system, pupae P8    16 head, virgin 1-day female    15 head, virgin 4-day female    15 head, virgin 20-day female    15 head, mated 1-day female    16 head, mated 4-day female    11 head, mated 20-day female    14 head, mated 1-day male    17 head, mated 4-day male    18 head, mated 20-day male    21 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    20 digestive system, 1-day adult    13 digestive system, 4-day adult    12 digestive system, 20-day adult    12 fat body, larvae L3 wandering    13 fat body, white prepupae    17 fat body, pupae P8    15 carcass, larvae L3 wandering    36 carcass, 1-day adult    16 carcass, 4-day adult    17 carcass, 20-day adult    18 ovary, virgin 4-day female    66 ovary, mated 4-day female    72 testis, mated 4-day male    28 accessory gland, mated 4-day male    19 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    50 central nervous system, larvae L3    61 central nervous system, pupae P8    16 head, virgin 1-day female    15 head, virgin 4-day female    15 head, virgin 20-day female    15 head, mated 1-day female    16 head, mated 4-day female    11 head, mated 20-day female    14 head, mated 1-day male    17 head, mated 4-day male    18 head, mated 20-day male    21 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    20 digestive system, 1-day adult    13 digestive system, 4-day adult    12 digestive system, 20-day adult    12 fat body, larvae L3 wandering    13 fat body, white prepupae    17 fat body, pupae P8    15 carcass, larvae L3 wandering    36 carcass, 1-day adult    16 carcass, 4-day adult    17 carcass, 20-day adult    18 ovary, virgin 4-day female    66 ovary, mated 4-day female    72 testis, mated 4-day male    28 accessory gland, mated 4-day male    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (50) central nervous system, larvae L3  (61) central nervous system, pupae P8    16 head, virgin 1-day female    15 head, virgin 4-day female    15 head, virgin 20-day female    15 head, mated 1-day female    16 head, mated 4-day female    11 head, mated 20-day female    14 head, mated 1-day male    17 head, mated 4-day male    18 head, mated 20-day male    21 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    20 digestive system, 1-day adult    13 digestive system, 4-day adult    12 digestive system, 20-day adult    12 fat body, larvae L3 wandering    13 fat body, white prepupae    17 fat body, pupae P8    15 carcass, larvae L3 wandering  (36) carcass, 1-day adult    16 carcass, 4-day adult    17 carcass, 20-day adult    18 ovary, virgin 4-day female  (66) ovary, mated 4-day female  (72) testis, mated 4-day male  28 accessory gland, mated 4-day male    19 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    50 central nervous system, larvae L3    61 central nervous system, pupae P8    16 head, virgin 1-day female    15 head, virgin 4-day female    15 head, virgin 20-day female    15 head, mated 1-day female    16 head, mated 4-day female    11 head, mated 20-day female    14 head, mated 1-day male    17 head, mated 4-day male    18 head, mated 20-day male    21 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    20 digestive system, 1-day adult    13 digestive system, 4-day adult    12 digestive system, 20-day adult    12 fat body, larvae L3 wandering    13 fat body, white prepupae    17 fat body, pupae P8    15 carcass, larvae L3 wandering    36 carcass, 1-day adult    16 carcass, 4-day adult    17 carcass, 20-day adult    18 ovary, virgin 4-day female    66 ovary, mated 4-day female    72 testis, mated 4-day male    28 accessory gland, mated 4-day male    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    50 central nervous system, larvae L3    61 central nervous system, pupae P8    16 head, virgin 1-day female    15 head, virgin 4-day female    15 head, virgin 20-day female    15 head, mated 1-day female    16 head, mated 4-day female    11 head, mated 20-day female    14 head, mated 1-day male    17 head, mated 4-day male    18 head, mated 20-day male    21 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    20 digestive system, 1-day adult    13 digestive system, 4-day adult    12 digestive system, 20-day adult    12 fat body, larvae L3 wandering    13 fat body, white prepupae    17 fat body, pupae P8    15 carcass, larvae L3 wandering    36 carcass, 1-day adult    16 carcass, 4-day adult    17 carcass, 20-day adult    18 ovary, virgin 4-day female    66 ovary, mated 4-day female    72 testis, mated 4-day male    28 accessory gland, mated 4-day male    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    58 embryo 02-04hr    85 embryo 04-06hr    68 embryo 06-08hr    49 embryo 08-10hr    47 embryo 10-12hr    38 embryo 12-14hr    25 embryo 14-16hr    20 embryo 16-18hr    16 embryo 18-20hr    12 embryo 20-22hr    12 embryo 22-24hr    12 larva L1    12 larva L2    14 larva L3 12hr old    13 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    17 white prepupae new    17 white prepupae 12hr    21 white prepupae 24hr    22 pupae 2d postWPP    12 pupae 3d postWPP    9 pupae 4d postWPP    9 adult male 01day    10 adult male 05day    12 adult male 30day    11 adult female 01day    20 adult female 05day    30 adult female 30day    32 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (58) embryo 02-04hr  (85) embryo 04-06hr  (68) embryo 06-08hr  (49) embryo 08-10hr  (47) embryo 10-12hr  (38) embryo 12-14hr    25 embryo 14-16hr    20 embryo 16-18hr    16 embryo 18-20hr    12 embryo 20-22hr    12 embryo 22-24hr    12 larva L1    12 larva L2    14 larva L3 12hr old    13 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    17 white prepupae new    17 white prepupae 12hr    21 white prepupae 24hr    22 pupae 2d postWPP    12 pupae 3d postWPP    9 pupae 4d postWPP    9 adult male 01day    10 adult male 05day    12 adult male 30day    11 adult female 01day    20 adult female 05day  (30) adult female 30day  (32) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    58 embryo 02-04hr    85 embryo 04-06hr    68 embryo 06-08hr    49 embryo 08-10hr    47 embryo 10-12hr    38 embryo 12-14hr    25 embryo 14-16hr    20 embryo 16-18hr    16 embryo 18-20hr    12 embryo 20-22hr    12 embryo 22-24hr    12 larva L1    12 larva L2    14 larva L3 12hr old    13 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    17 white prepupae new    17 white prepupae 12hr    21 white prepupae 24hr    22 pupae 2d postWPP    12 pupae 3d postWPP    9 pupae 4d postWPP    9 adult male 01day    10 adult male 05day    12 adult male 30day    11 adult female 01day    20 adult female 05day    30 adult female 30day    32 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    58 embryo 02-04hr    85 embryo 04-06hr    68 embryo 06-08hr    49 embryo 08-10hr    47 embryo 10-12hr    38 embryo 12-14hr    25 embryo 14-16hr    20 embryo 16-18hr    16 embryo 18-20hr    12 embryo 20-22hr    12 embryo 22-24hr    12 larva L1    12 larva L2    14 larva L3 12hr old    13 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    17 white prepupae new    17 white prepupae 12hr    21 white prepupae 24hr    22 pupae 2d postWPP    12 pupae 3d postWPP    9 pupae 4d postWPP    9 adult male 01day    10 adult male 05day    12 adult male 30day    11 adult female 01day    20 adult female 05day    30 adult female 30day    32 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    58 embryo 02-04hr    85 embryo 04-06hr    68 embryo 06-08hr    49 embryo 08-10hr    47 embryo 10-12hr    38 embryo 12-14hr    25 embryo 14-16hr    20 embryo 16-18hr    16 embryo 18-20hr    12 embryo 20-22hr    12 embryo 22-24hr    12 larva L1    12 larva L2    14 larva L3 12hr old    13 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    17 white prepupae new    17 white prepupae 12hr    21 white prepupae 24hr    22 pupae 2d postWPP    12 pupae 3d postWPP    9 pupae 4d postWPP    9 adult male 01day    10 adult male 05day    12 adult male 30day    11 adult female 01day    20 adult female 05day    30 adult female 30day    32 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (58) embryo 02-04hr  (85) embryo 04-06hr  (68) embryo 06-08hr  (49) embryo 08-10hr  (47) embryo 10-12hr  (38) embryo 12-14hr    25 embryo 14-16hr    20 embryo 16-18hr    16 embryo 18-20hr    12 embryo 20-22hr    12 embryo 22-24hr    12 larva L1    12 larva L2    14 larva L3 12hr old    13 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    17 white prepupae new    17 white prepupae 12hr    21 white prepupae 24hr    22 pupae 2d postWPP    12 pupae 3d postWPP    9 pupae 4d postWPP    9 adult male 01day    10 adult male 05day    12 adult male 30day    11 adult female 01day    20 adult female 05day  30 adult female 30day  32 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    58 embryo 02-04hr    85 embryo 04-06hr    68 embryo 06-08hr    49 embryo 08-10hr    47 embryo 10-12hr    38 embryo 12-14hr    25 embryo 14-16hr    20 embryo 16-18hr    16 embryo 18-20hr    12 embryo 20-22hr    12 embryo 22-24hr    12 larva L1    12 larva L2    14 larva L3 12hr old    13 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    17 white prepupae new    17 white prepupae 12hr    21 white prepupae 24hr    22 pupae 2d postWPP    12 pupae 3d postWPP    9 pupae 4d postWPP    9 adult male 01day    10 adult male 05day    12 adult male 30day    11 adult female 01day    20 adult female 05day    30 adult female 30day    32 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    58 embryo 02-04hr    85 embryo 04-06hr    68 embryo 06-08hr    49 embryo 08-10hr    47 embryo 10-12hr    38 embryo 12-14hr    25 embryo 14-16hr    20 embryo 16-18hr    16 embryo 18-20hr    12 embryo 20-22hr    12 embryo 22-24hr    12 larva L1    12 larva L2    14 larva L3 12hr old    13 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    17 white prepupae new    17 white prepupae 12hr    21 white prepupae 24hr    22 pupae 2d postWPP    12 pupae 3d postWPP    9 pupae 4d postWPP    9 adult male 01day    10 adult male 05day    12 adult male 30day    11 adult female 01day    20 adult female 05day    30 adult female 30day    32 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    60 Schneider line 2 Sg4    59 embryonic 1182-4H    43 embryonic GM2    36 embryonic Kc167    32 embryonic S1    78 embryonic S3    40 leg disc CME L1    53 wing disc CME-W2    29 wing disc ML-DmD8    41 wing disc ML-DmD9    47 wing disc ML-DmD16-c3    60 wing disc ML-DmD21    75 wing disc ML-DmD32    65 haltere disc ML-DmD17-c3    52 eye-antennal disc ML-DmD11    47 antennal disc ML-DmD20-c5    58 mixed discs ML-DmD4-c1    50 CNS ML-DmBG1-c1    42 CNS ML-DmBG2-c2    40 tumorous blood cells mbn2    27 ovary fGS/OSS    38 ovary OSC    35 ovary OSS    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (60) Schneider line 2 Sg4  (59) embryonic 1182-4H  (43) embryonic GM2  (36) embryonic Kc167  (32) embryonic S1  (78) embryonic S3  (40) leg disc CME L1  (53) wing disc CME-W2  (29) wing disc ML-DmD8  (41) wing disc ML-DmD9  (47) wing disc ML-DmD16-c3  (60) wing disc ML-DmD21  (75) wing disc ML-DmD32  (65) haltere disc ML-DmD17-c3  (52) eye-antennal disc ML-DmD11  (47) antennal disc ML-DmD20-c5  (58) mixed discs ML-DmD4-c1  (50) CNS ML-DmBG1-c1  (42) CNS ML-DmBG2-c2  (40) tumorous blood cells mbn2  (27) ovary fGS/OSS  (38) ovary OSC  (35) ovary OSS    23 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    60 Schneider line 2 Sg4    59 embryonic 1182-4H    43 embryonic GM2    36 embryonic Kc167    32 embryonic S1    78 embryonic S3    40 leg disc CME L1    53 wing disc CME-W2    29 wing disc ML-DmD8    41 wing disc ML-DmD9    47 wing disc ML-DmD16-c3    60 wing disc ML-DmD21    75 wing disc ML-DmD32    65 haltere disc ML-DmD17-c3    52 eye-antennal disc ML-DmD11    47 antennal disc ML-DmD20-c5    58 mixed discs ML-DmD4-c1    50 CNS ML-DmBG1-c1    42 CNS ML-DmBG2-c2    40 tumorous blood cells mbn2    27 ovary fGS/OSS    38 ovary OSC    35 ovary OSS    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    60 Schneider line 2 Sg4    59 embryonic 1182-4H    43 embryonic GM2    36 embryonic Kc167    32 embryonic S1    78 embryonic S3    40 leg disc CME L1    53 wing disc CME-W2    29 wing disc ML-DmD8    41 wing disc ML-DmD9    47 wing disc ML-DmD16-c3    60 wing disc ML-DmD21    75 wing disc ML-DmD32    65 haltere disc ML-DmD17-c3    52 eye-antennal disc ML-DmD11    47 antennal disc ML-DmD20-c5    58 mixed discs ML-DmD4-c1    50 CNS ML-DmBG1-c1    42 CNS ML-DmBG2-c2    40 tumorous blood cells mbn2    27 ovary fGS/OSS    38 ovary OSC    35 ovary OSS    23 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    60 Schneider line 2 Sg4    59 embryonic 1182-4H    43 embryonic GM2    36 embryonic Kc167    32 embryonic S1    78 embryonic S3    40 leg disc CME L1    53 wing disc CME-W2    29 wing disc ML-DmD8    41 wing disc ML-DmD9    47 wing disc ML-DmD16-c3    60 wing disc ML-DmD21    75 wing disc ML-DmD32    65 haltere disc ML-DmD17-c3    52 eye-antennal disc ML-DmD11    47 antennal disc ML-DmD20-c5    58 mixed discs ML-DmD4-c1    50 CNS ML-DmBG1-c1    42 CNS ML-DmBG2-c2    40 tumorous blood cells mbn2    27 ovary fGS/OSS    38 ovary OSC    35 ovary OSS    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (60) Schneider line 2 Sg4  (59) embryonic 1182-4H  (43) embryonic GM2  (36) embryonic Kc167  32 embryonic S1  (78) embryonic S3  (40) leg disc CME L1  (53) wing disc CME-W2  29 wing disc ML-DmD8  (41) wing disc ML-DmD9  (47) wing disc ML-DmD16-c3  (60) wing disc ML-DmD21  (75) wing disc ML-DmD32  (65) haltere disc ML-DmD17-c3  (52) eye-antennal disc ML-DmD11  (47) antennal disc ML-DmD20-c5  (58) mixed discs ML-DmD4-c1  (50) CNS ML-DmBG1-c1  (42) CNS ML-DmBG2-c2  (40) tumorous blood cells mbn2  27 ovary fGS/OSS  (38) ovary OSC  (35) ovary OSS    23 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    60 Schneider line 2 Sg4    59 embryonic 1182-4H    43 embryonic GM2    36 embryonic Kc167    32 embryonic S1    78 embryonic S3    40 leg disc CME L1    53 wing disc CME-W2    29 wing disc ML-DmD8    41 wing disc ML-DmD9    47 wing disc ML-DmD16-c3    60 wing disc ML-DmD21    75 wing disc ML-DmD32    65 haltere disc ML-DmD17-c3    52 eye-antennal disc ML-DmD11    47 antennal disc ML-DmD20-c5    58 mixed discs ML-DmD4-c1    50 CNS ML-DmBG1-c1    42 CNS ML-DmBG2-c2    40 tumorous blood cells mbn2    27 ovary fGS/OSS    38 ovary OSC    35 ovary OSS    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    60 Schneider line 2 Sg4    59 embryonic 1182-4H    43 embryonic GM2    36 embryonic Kc167    32 embryonic S1    78 embryonic S3    40 leg disc CME L1    53 wing disc CME-W2    29 wing disc ML-DmD8    41 wing disc ML-DmD9    47 wing disc ML-DmD16-c3    60 wing disc ML-DmD21    75 wing disc ML-DmD32    65 haltere disc ML-DmD17-c3    52 eye-antennal disc ML-DmD11    47 antennal disc ML-DmD20-c5    58 mixed discs ML-DmD4-c1    50 CNS ML-DmBG1-c1    42 CNS ML-DmBG2-c2    40 tumorous blood cells mbn2    27 ovary fGS/OSS    38 ovary OSC    35 ovary OSS    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    27 cold shock, 4-day adult    25 heat shock, 4-day adult    30 Cadmium 50 mM 6 hrs, larvae L3    33 Cadmium 50 mM 12 hrs, larvae L3    25 Cadmium 50 mM 48 hrs, 4-day adult    34 Cadmium 100 mM 48 hrs, 4-day adult    54 Copper 0.5 mM 12 hrs, larvae L3    19 Copper 15 mM 48 hrs, 4-day adult    16 Zinc 5 mM 12 hrs, larvae L3    29 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3    50 Ethanol 5% 3 hrs, larvae L3    21 Ethanol 10% 3 hrs, larvae L3    21 Caffeine 1.5 mg/ml 4 hrs, larvae L3    17 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    65 Caffeine 25 mg/ml 48 hrs, 4-day adult    27 Paraquat 5 mM 48 hrs, 4-day adult    53 Paraquat 10 mM 48 hrs, 4-day adult    33 Rotenone 2 μg 12 hrs, larvae L3    24 Rotenone 8 μg 12 hrs, larvae L3    30 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (27) cold shock, 4-day adult    25 heat shock, 4-day adult  (30) Cadmium 50 mM 6 hrs, larvae L3  (33) Cadmium 50 mM 12 hrs, larvae L3    25 Cadmium 50 mM 48 hrs, 4-day adult  (34) Cadmium 100 mM 48 hrs, 4-day adult  (54) Copper 0.5 mM 12 hrs, larvae L3    19 Copper 15 mM 48 hrs, 4-day adult    16 Zinc 5 mM 12 hrs, larvae L3  (29) Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3  (50) Ethanol 5% 3 hrs, larvae L3    21 Ethanol 10% 3 hrs, larvae L3    21 Caffeine 1.5 mg/ml 4 hrs, larvae L3    17 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (65) Caffeine 25 mg/ml 48 hrs, 4-day adult  (27) Paraquat 5 mM 48 hrs, 4-day adult  (53) Paraquat 10 mM 48 hrs, 4-day adult  (33) Rotenone 2 μg 12 hrs, larvae L3    24 Rotenone 8 μg 12 hrs, larvae L3  (30) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    27 cold shock, 4-day adult    25 heat shock, 4-day adult    30 Cadmium 50 mM 6 hrs, larvae L3    33 Cadmium 50 mM 12 hrs, larvae L3    25 Cadmium 50 mM 48 hrs, 4-day adult    34 Cadmium 100 mM 48 hrs, 4-day adult    54 Copper 0.5 mM 12 hrs, larvae L3    19 Copper 15 mM 48 hrs, 4-day adult    16 Zinc 5 mM 12 hrs, larvae L3    29 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3    50 Ethanol 5% 3 hrs, larvae L3    21 Ethanol 10% 3 hrs, larvae L3    21 Caffeine 1.5 mg/ml 4 hrs, larvae L3    17 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    65 Caffeine 25 mg/ml 48 hrs, 4-day adult    27 Paraquat 5 mM 48 hrs, 4-day adult    53 Paraquat 10 mM 48 hrs, 4-day adult    33 Rotenone 2 μg 12 hrs, larvae L3    24 Rotenone 8 μg 12 hrs, larvae L3    30 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    27 cold shock, 4-day adult    25 heat shock, 4-day adult    30 Cadmium 50 mM 6 hrs, larvae L3    33 Cadmium 50 mM 12 hrs, larvae L3    25 Cadmium 50 mM 48 hrs, 4-day adult    34 Cadmium 100 mM 48 hrs, 4-day adult    54 Copper 0.5 mM 12 hrs, larvae L3    19 Copper 15 mM 48 hrs, 4-day adult    16 Zinc 5 mM 12 hrs, larvae L3    29 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3    50 Ethanol 5% 3 hrs, larvae L3    21 Ethanol 10% 3 hrs, larvae L3    21 Caffeine 1.5 mg/ml 4 hrs, larvae L3    17 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    65 Caffeine 25 mg/ml 48 hrs, 4-day adult    27 Paraquat 5 mM 48 hrs, 4-day adult    53 Paraquat 10 mM 48 hrs, 4-day adult    33 Rotenone 2 μg 12 hrs, larvae L3    24 Rotenone 8 μg 12 hrs, larvae L3    30 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    27 cold shock, 4-day adult    25 heat shock, 4-day adult    30 Cadmium 50 mM 6 hrs, larvae L3    33 Cadmium 50 mM 12 hrs, larvae L3    25 Cadmium 50 mM 48 hrs, 4-day adult    34 Cadmium 100 mM 48 hrs, 4-day adult    54 Copper 0.5 mM 12 hrs, larvae L3    19 Copper 15 mM 48 hrs, 4-day adult    16 Zinc 5 mM 12 hrs, larvae L3    29 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3    50 Ethanol 5% 3 hrs, larvae L3    21 Ethanol 10% 3 hrs, larvae L3    21 Caffeine 1.5 mg/ml 4 hrs, larvae L3    17 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    65 Caffeine 25 mg/ml 48 hrs, 4-day adult    27 Paraquat 5 mM 48 hrs, 4-day adult    53 Paraquat 10 mM 48 hrs, 4-day adult    33 Rotenone 2 μg 12 hrs, larvae L3    24 Rotenone 8 μg 12 hrs, larvae L3    30 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  27 cold shock, 4-day adult    25 heat shock, 4-day adult  30 Cadmium 50 mM 6 hrs, larvae L3  (33) Cadmium 50 mM 12 hrs, larvae L3    25 Cadmium 50 mM 48 hrs, 4-day adult  (34) Cadmium 100 mM 48 hrs, 4-day adult  (54) Copper 0.5 mM 12 hrs, larvae L3    19 Copper 15 mM 48 hrs, 4-day adult    16 Zinc 5 mM 12 hrs, larvae L3  29 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3  (50) Ethanol 5% 3 hrs, larvae L3    21 Ethanol 10% 3 hrs, larvae L3    21 Caffeine 1.5 mg/ml 4 hrs, larvae L3    17 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (65) Caffeine 25 mg/ml 48 hrs, 4-day adult  27 Paraquat 5 mM 48 hrs, 4-day adult  (53) Paraquat 10 mM 48 hrs, 4-day adult  (33) Rotenone 2 μg 12 hrs, larvae L3    24 Rotenone 8 μg 12 hrs, larvae L3  30 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    27 cold shock, 4-day adult    25 heat shock, 4-day adult    30 Cadmium 50 mM 6 hrs, larvae L3    33 Cadmium 50 mM 12 hrs, larvae L3    25 Cadmium 50 mM 48 hrs, 4-day adult    34 Cadmium 100 mM 48 hrs, 4-day adult    54 Copper 0.5 mM 12 hrs, larvae L3    19 Copper 15 mM 48 hrs, 4-day adult    16 Zinc 5 mM 12 hrs, larvae L3    29 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3    50 Ethanol 5% 3 hrs, larvae L3    21 Ethanol 10% 3 hrs, larvae L3    21 Caffeine 1.5 mg/ml 4 hrs, larvae L3    17 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    65 Caffeine 25 mg/ml 48 hrs, 4-day adult    27 Paraquat 5 mM 48 hrs, 4-day adult    53 Paraquat 10 mM 48 hrs, 4-day adult    33 Rotenone 2 μg 12 hrs, larvae L3    24 Rotenone 8 μg 12 hrs, larvae L3    30 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    27 cold shock, 4-day adult    25 heat shock, 4-day adult    30 Cadmium 50 mM 6 hrs, larvae L3    33 Cadmium 50 mM 12 hrs, larvae L3    25 Cadmium 50 mM 48 hrs, 4-day adult    34 Cadmium 100 mM 48 hrs, 4-day adult    54 Copper 0.5 mM 12 hrs, larvae L3    19 Copper 15 mM 48 hrs, 4-day adult    16 Zinc 5 mM 12 hrs, larvae L3    29 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3    50 Ethanol 5% 3 hrs, larvae L3    21 Ethanol 10% 3 hrs, larvae L3    21 Caffeine 1.5 mg/ml 4 hrs, larvae L3    17 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    65 Caffeine 25 mg/ml 48 hrs, 4-day adult    27 Paraquat 5 mM 48 hrs, 4-day adult    53 Paraquat 10 mM 48 hrs, 4-day adult    33 Rotenone 2 μg 12 hrs, larvae L3    24 Rotenone 8 μg 12 hrs, larvae L3    30 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_17 mE1_20_mRNA_expression_cluster_04
External Data & Images
Linkouts	BDGP expression data • LD22902 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0027378 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6363-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for MRG15 Stages(s) 1-3 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | pupal stage, with Scer\GAL4pnr-MD237 MRG15GD11902 lethal | recessive MRG15j6A3 viable MRG15ex1 Sterility Allele female semi-sterile, with Tn10\tetRAct5C.T:Hsim\VP16 MRG15dsRNA.Tn10\tetO MRG15MT1.Tn10\tetO.T:Ivir\HA1 Other Phenotypes Allele non-suppressor of variegation, with T(1;4)wm258-21 MRG15ex1 short lived, with Tn10\tetRAct5C.T:Hsim\VP16 MRG15dsRNA.Tn10\tetO short lived | male limited, with Scer\GAL4Act5C.Switch.PR MRG15GD11902 suppressor of variegation | dominant, with T(1;4)wm258-21 MRG15j6A3 Phenotype manifest in Allele
Classical Alleles ( 3 )
For All Classical Alleles Show
Allele of MRG15 Class Mutagen Stocks Known lesion MRG15j6A3 P-element activity 2 Yes MRG151 P-element activity 0 Yes MRG15ex1 P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Allele of MRG15 Class Mutagen Stocks Known lesion MRG15GD11902 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes MRG15GL00128 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes MRG15dsRNA.cKa in vitro construct - RNAi 0 Yes MRG15dsRNA.Tn10\tetO in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes MRG15KK107689 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes MRG15MT1.Tn10\tetO.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes MRG15Tn10\tetO.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)BSC741 (Cook et al., 2009.2.28) Df(3R)E(mod)4-1P1 (Pai et al., 2004) Df(3R)E(mod)4-1P11 (Pai et al., 2004) Df(3R)Exel7323 (Ryder, 2004.4.26) Df(3R)P280-NR27 (Butcher et al., 2004)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11902} NA P{KK107689} NA P{tetO-MRG15.dsRNA} NA P{tetO-MRG15-HA.MT1} NA P{tetO-MRG15-HA} NA P{TRiP.GL00128} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}MRG15j6A3 No
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 6 terms )
Molecular Function
CV term Evidence References
methylated histone residue binding inferred from direct assay (Moore et al., 2010)
Biological Process
CV term Evidence References
chromatin silencing inferred from mutant phenotype (Qi et al., 2006) histone acetylation inferred from direct assay (Kusch et al., 2004) histone exchange inferred from direct assay (Kusch et al., 2004)
Cellular Component
CV term Evidence References
histone acetyltransferase complex inferred from physical interaction with pont (Kusch et al., 2004) nucleus inferred from direct assay (Kusch et al., 2004)
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function ( 0 terms)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
nucleus non-traceable author statement (Bertram, 1999.5.17, Swiss-Prot Project Members, 2000.2.15)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
MRG15 - Atg4 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) MRG15 - CG11504 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) MRG15 - CG3344 experimental knowledge based (Guruharsha et al., 2011) MRG15 - CG7206 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) MRG15 - CG8677 anti bait coimmunoprecipitation, western blot (Hanai et al., 2008) MRG15 - Cct2 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) MRG15 - Cyp6a13 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) MRG15 - His2Av anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) MRG15 - Hmgs experimental knowledge based (Guruharsha et al., 2011) MRG15 - Hsp22 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) MRG15 - Hsp23 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) MRG15 - Hsp68 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) MRG15 - Hsp70Aa anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) MRG15 - Lst8 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) MRG15 - MrgBP anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) MRG15 - PSR experimental knowledge based (Guruharsha et al., 2011) MRG15 - SPE experimental knowledge based (Guruharsha et al., 2011) MRG15 - Syp anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) MRG15 - Tap42 experimental knowledge based (Guruharsha et al., 2011) MRG15 - Vap-33-1 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) MRG15 - Vha55 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) MRG15 - igl experimental knowledge based (Guruharsha et al., 2011) MRG15 - mts experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) MRG15 - nwk experimental knowledge based (Guruharsha et al., 2011)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions MRG15 allele Gene References unspecified Pc (Qi et al., 2006) Psc (Qi et al., 2006)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 66914 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0027378 DroID - A comprehensive database of gene and protein interactions. • FBgn0027378 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41850
Orthologs
OrthoDB Orthologs (49) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG68KRX7 Dipteran inclusive ortholog search EOG6SN1XQ Insect inclusive ortholog search EOG63BKK0 Arthropod inclusive ortholog search EOG6612M2 Metazoa inclusive ortholog search EOG6Q8HRV
Orthologs in Drosophila Species (EOG68KRX7)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\MRG15     Drosophila simulans   Dsim\GD20365 Y   Drosophila sechellia   Dsec\GM25788 Y   Drosophila erecta   Dere\GG20726 Y   Drosophila yakuba   Dyak\GE26393 Y   Drosophila ananassae   Dana\GF11736 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA19541 Y   Drosophila persimilis   Dper\GL12068 Y   Drosophila willistoni   Dwil\GK13489 Y   Drosophila virilis   Dvir\GJ24036 Y   Drosophila mojavensis   Dmoj\GI24663 Y   Drosophila grimshawi   Dgri\GH18746 Y
Orthologs in non-Drosophila Dipterans (EOG6SN1XQ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL002772   Anopheles gambiae Malaria mosquito  Agam\AGAP001795   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ020081   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ013367
Orthologs in non-Dipteran Insects (EOG63BKK0)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC413181   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG001120   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG001439   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH19816   Atta cephalotes Leafcutter ant  Acep\ACEP17426   Camponotus floridanus Florida carpenter ant  Cflo\CFLO16347   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL12905   Linepithema humile Argentine ant  Lhum\LH12602   Pogonomyrmex barbatus Red harvester ant  Pbar\PB17172   Solenopsis invicta Red fire ant  Sinv\SINV11038   Acyrthosiphon pisum Pea aphid  Apim\ACYPI29468   Acyrthosiphon pisum Pea aphid  Apim\ACYPI003457   Bombyx mori Silkmoth  Bmor\BGIBMGA001581   Pediculus humanus Human body louse  Phum\PHUM400130   Tribolium castaneum Red flour beetle  Tcas\TC011468
Orthologs in non-Insect Arthropods (EOG6612M2)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_299826   Ixodes scapularis Deer tick  Isca\ISCW000087
Orthologs in non-Arthropod Metazoa (EOG6Q8HRV)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\cec-7   Caenorhabditis elegans Nematode  Cele\mrg-1   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_002722gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_016691gn   Danio rerio Zebrafish  Drer\morf4l1   Xenopus tropicalis Western clawed frog  Xtro\morf4l1   Gallus gallus Domestic chicken  Ggal\MORF4L1   Mus musculus House mouse  Mmus\Morf4l1   Mus musculus House mouse  Mmus\Morf4l2   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000027827   Rattus norvegicus Norway rat  Rnor\Morf4l2   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000028964   Rattus norvegicus Norway rat  Rnor\Morf4l1   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000036868   Homo sapiens Human  Hsap\MORF4L1   Homo sapiens Human  Hsap\MORF4L2
Human Orthologs (2)
Gene OMIM HGNC Hsap\MORF4L1     Hsap\MORF4L2
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD20365 Drosophila sechellia Dsec\GM25788 Drosophila erecta Dere\GG20726 Drosophila yakuba Dyak\GE26393 Drosophila ananassae Dana\GF11736 Drosophila pseudoobscura pseudoobscura Dpse\GA19541 Drosophila persimilis Dper\GL12068 Drosophila willistoni Dwil\GK13489 Drosophila virilis Dvir\GJ24036 Drosophila mojavensis Dmoj\GI24663 Drosophila grimshawi Dgri\GH18746
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	10290 y1 w1118; P{lacW}MRG15j6A3/TM3, Sb1 35241 y1 sc* v1; P{TRiP.GL00128}attP2/TM3, Sb1
Kyoto	111041 yd2 w1118 P{ey-FLP.N}2 P{GMR-lacZ.C(38.1)}TPN1; P{neoFRT}82B P{lacW}MRG15j6A3/TM6B, P{Car20y}TPN1, Tb1
VDRC	v43802 w1118; P{GD11902}v43802 v43800 w1118; P{GD11902}v43800/TM3
Genomic Clones ( 1 )
	BACR13A02 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 135 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD22902
Other clones	DPiM_LD22902
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH15158 GH22871 LD14159 LD18041 LD25342 LD31882 LD38932 LD47757 RE11273 RE25046 RE50077 RE50326 RE50466 RE52917 RE62877 RE63571 RH59987 SD05151 SD20874
Other clones	75546 190740 Dmel_dig_000452_0702_3631 EK293061 EN07804 LD22492 RP003010749 RP003015860 RP003016020 RP003049141 RP003049300 RP003054045 RP003054984 RP003058129 RP003058351 RP003065372 RP003068722 RP003069173 RP003079642 RP003085074 RP003091879 RP003092506 RP003118290 RP003120227 RP003121052 RP003129465 RP003133919 RP003134618 RP003143720 RP003145970 RP003150924 RP003152142 RP003152718 RP003153223 RP003165884 RP003170697 RP003188299 RP003188442 RP003193438 RP003196538 RP003199851 RP003199901 RP003205953 RP003217961 RP003233772 RP003234938 RP003237606 RP003239169 RP003244354 RP003246440 RP003248921 RP003249068 RP003252767 RP003253511 RP003254868 RP003257199 RP003257581 RP003258359 RP003258814 RP003268185 RP003268608 RP003271623 RP003273865 RP003274774 RP003275829 RP003294362 RP003302266 RP003310626 RP003327597 RP003342956 RP003348427 RP003353695 RP003357713 RP003363622 RP003381022 RP003393031 RP003395609 RP003395710 RP003405207 RP003429652 RP003431750 RP003435989 RP003442266 RP003447520 RP003451536 RP003455433 RP003465664 RP003466796 RP003468608 RP003469886 RP003473912 RP003476548 RP003496801 RP003497908 RP003505028 RP003511364 RP003527974 RP003539710 RP003546419 RP003556375 RP003580914 RP003600474 RP003601576 RP003608188 RP003608516 RP003626758 RP003626760 RP003627504 RP003658293 RP003660363 RP003663977 RP003666672 RP003667697 RP003675211
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0027378 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41850
Antibody Information
	polyclonal (Riddle et al., 2012)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: MRG15 CG6363 (Zheng, 1999.11)
Source for database merge of
Additional comments
Other Comments
	DNA-protein interactions: genome-wide binding profile assayed for MRG15 protein in Kc167 cells; see Chromatin_types_NKI collection report. Individual protein-binding experiments listed under "Samples" at GEO_GSE22069 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE22069). (Filion et al., 2010) MRG15 gene function limits survival during larval and adult stages of development. (Zhang et al., 2010) FlyBase curator comment: LD18041 stated to correspond to l(3)neo43, though BLAST of LD18041 vs R3.2 predicted genes identifies MRG15 but not CG14865. (Spradling et al., 1999)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_142185 NM_001275659 RefSeq (Proteins) • NP_650442 NP_001262588 DDBJ / EMBL / GenBank • AA539729 AA817270 AA940732 AA941284 AA951428 AAD38047 AAF55161 AAK93103 AF152245 AGB95969 AI238997 AQ026327 AW942657 AY051679 BG638308 Entrez Gene - A searchable database of RefSeq genes. • 41850 UniProtKB/Swiss-Prot • Q9Y0I1
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Chromo domain/shadow (IPR000953) MRG (IPR008676) Chromo domain-like (IPR016197) RNA binding activity-knot of a chromodomain (IPR025995) MRG domain (IPR026541) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD22902
Linkouts
	BioGRID - A database of protein and genetic interactions • 66914 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0027378 DroID - A comprehensive database of gene and protein interactions. • FBgn0027378 DRSC - Results from RNAi screens. • FBgn0027378 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0027378 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6363-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0027378 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41850 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41850 modMine - Data generated by the modENCODE project. • FBgn0027378
Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym	CG6363 (Butcher et al., 2004, Kusch et al., 2004, Zhang et al., 2010, Keleman et al., 2009.8.5, Ni et al., 2011.7.19) DmMRG15 (Pannuti and Lucchesi, 2000, Marin and Baker, 2000) dMrg15 (Raisner, 2006, Kusch et al., 2004, Kusch et al., 2004, Jin, 2005) dMRG15 (Dai et al., 2005, Qi et al., 2006, Hanai et al., 2008, Moore et al., 2010) Dmrg15 (Bertram and Thompson, 2001) l(3)j6A3 (Spradling et al., 1999, ) MRG15 (Pai et al., 2004, Kharchenko et al., 2011, Zhang et al., 2010, Doheny et al., 2008, Cook et al., 2009.2.28, Joyce et al., 2011, Moshkin et al., 2009, Filion et al., 2010, Moore et al., 2010, Wang et al., 2013) Mrg15 (Lee et al., 2009)
Name Synonym	MRG15
Secondary FlyBase IDs
	FBgn0024526
References ( 48 )
Generate a list of	All references relating to this gene ( 48 )
List References by type	Research paper  ( 20 ) Supplementary material  ( 6 ) Review  ( 4 ) Personal communication to FlyBase  ( 9 ) Abstract  ( 2 ) FlyBase analysis  ( 1 ) Curated genome annotation  ( 2 ) DNA/RNA sequence record  ( 1 ) Protein sequence record  ( 1 ) Website  ( 1 )
Recent research papers ( 4 )
	Wang et al., 2013, Nat. Struct. Mol. Biol. 20(2): 202--209 Chromatin proteins captured by ChIP-mass spectrometry are linked to dosage compensation in Drosophila. [FBrf0220693] Riddle et al., 2012, PLoS Genet. 8(9): e1002954 Enrichment of HP1a on Drosophila Chromosome 4 Genes Creates an Alternate Chromatin Structure Critical for Regulation in this Heterochromatic Domain. [FBrf0219520] Joyce et al., 2011, J. Cell Biol. 195(3): 359--367 Drosophila ATM and ATR have distinct activities in the regulation of meiotic DNA damage and repair. [FBrf0216489] Kharchenko et al., 2011, Nature 471(7339): 480--485 Comprehensive analysis of the chromatin landscape in Drosophila melanogaster. [FBrf0213294] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...