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Gene Dmel\Madm

General Information
Symbol	Dmel\Madm	Species	D. melanogaster
Name	MLF1-adaptor molecule	Annotation symbol	CG1098
Feature type	protein_coding_gene	FlyBase ID	FBgn0027497
Gene Model Status	Current	Stock availability	7 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	83C2-83C2	Sequence location	3R:1,568,232..1,571,789 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene MLF1-adaptor molecule is referred to in FlyBase by the symbol Dmel\Madm (CG1098, FBgn0027497). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: protein serine/threonine kinase activity. There is experimental evidence that it is involved in the biological process: regulation of cell proliferation; protein secretion; regulation of cell size. 17 alleles are reported. The phenotype of these alleles is annotated with: trichogen cell. It has one annotated transcript and one annotated polypeptide. Protein features are: Protein kinase, catalytic domain; Protein kinase-like domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult central nervous system, adult crop, larval hindgut, larval/adult salivary gland, adult ovary, adult male accessory gland. Comments on Affy2 ProbeSet: ProbeSet 1639453_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Madm. Gene sequence location is 3R:1568232..1571789.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 83C2-83C2   Limits computationally determined from genome sequence between P{lacW}casj1C2 and P{PZ}lab01241
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Madm for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.47 Evidence indicates that 3' UTR overlaps transposon; extends to coordinate AE003602:309598 (based upon 3' extent of BcDNA:LD28657 )
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Madm-RA FBtr0078722  NM_141324   2706   637
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Madm-PA   FBpp0078371   70.5   637   4.75     NP_649581   AAF51961
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) Protein kinase-like domain (IPR011009)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA801514   AA802961   AA817584   AA941114   AA941834   AA950122   AE014297 AAF51961   AF145690 AAD38665   AI135076   AI532888   AI533270   AI533997   AI542804   AI542805   AQ073773   AX094282   BF496354   BG633679   BG635331   BG636735   BI172142   BI212342   BI231712   BI566150   BI567384   BI576228   BI579133   BI585382   BI592105   BI592170   BI635553   BI636636   BI638780   BQ103543   BT030974   CK604994   CK604995   CK662163   CO190160   CO293916   CO317148   CO337641   EC066612   EC201385   EC218275   EC265223
UniProtKB/Swiss-Prot	Q9Y0Y6
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | faint & ubiquitous   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | faint & ubiquitous   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   organism | faint & ubiquitous   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
cytosol inferred from direct assay (Bard et al., 2006) Golgi apparatus inferred from direct assay (Bard et al., 2006)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult central nervous system, adult crop, larval hindgut, larval/adult salivary gland, adult ovary, adult male accessory gland. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    99.95 Larval Midgut    66.5 Larval Hindgut    102.1 Larval Malpighian Tubules    90.6 Larval Fat Body    38.6 Larval Salivary Gland    137.9 Larval Trachea    82.975 Larval Carcass    82.025 Adult Head    53.6 Adult Eye    50.775 Adult Brain    157.7 Adult Thoracic-Abdominal Ganglion    139 Adult Crop    142.5 Adult Midgut    48 Adult Hindgut    89.1 Adult Malpighian Tubules    57.5 Adult Fat Body    45 Adult Salivary Gland    269.1 Adult Heart    67.675 Adult VirginFemale Spermatheca    75.1 Adult InseminatedFemale Spermatheca    72.4 Adult Ovary    109.8 Adult Testis    49.1 Adult Male Accessory Gland    113.8 Adult Carcass    50.3 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    99.95 Larval Midgut    66.5 Larval Hindgut    102.1 Larval Malpighian Tubules    90.6 Larval Fat Body    38.6 Larval Salivary Gland    137.9 Larval Trachea    82.975 Larval Carcass    82.025 Adult Head    53.6 Adult Eye    50.775 Adult Brain    157.7 Adult Thoracic-Abdominal Ganglion    139 Adult Crop    142.5 Adult Midgut    48 Adult Hindgut    89.1 Adult Malpighian Tubules    57.5 Adult Fat Body    45 Adult Salivary Gland    269.1 Adult Heart    67.675 Adult VirginFemale Spermatheca    75.1 Adult InseminatedFemale Spermatheca    72.4 Adult Ovary    109.8 Adult Testis    49.1 Adult Male Accessory Gland    113.8 Adult Carcass    50.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    99.95 Larval Midgut    66.5 Larval Hindgut    102.1 Larval Malpighian Tubules    90.6 Larval Fat Body    38.6 Larval Salivary Gland    137.9 Larval Trachea    82.975 Larval Carcass    82.025 Adult Head    53.6 Adult Eye    50.775 Adult Brain    157.7 Adult Thoracic-Abdominal Ganglion    139 Adult Crop    142.5 Adult Midgut    48 Adult Hindgut    89.1 Adult Malpighian Tubules    57.5 Adult Fat Body    45 Adult Salivary Gland    269.1 Adult Heart    67.675 Adult VirginFemale Spermatheca    75.1 Adult InseminatedFemale Spermatheca    72.4 Adult Ovary    109.8 Adult Testis    49.1 Adult Male Accessory Gland    113.8 Adult Carcass    50.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    99.95 Larval Midgut    66.5 Larval Hindgut    102.1 Larval Malpighian Tubules    90.6 Larval Fat Body    38.6 Larval Salivary Gland    137.9 Larval Trachea    82.975 Larval Carcass    82.025 Adult Head    53.6 Adult Eye    50.775 Adult Brain    157.7 Adult Thoracic-Abdominal Ganglion    139 Adult Crop    142.5 Adult Midgut    48 Adult Hindgut    89.1 Adult Malpighian Tubules    57.5 Adult Fat Body    45 Adult Salivary Gland    269.1 Adult Heart    67.675 Adult VirginFemale Spermatheca    75.1 Adult InseminatedFemale Spermatheca    72.4 Adult Ovary    109.8 Adult Testis    49.1 Adult Male Accessory Gland    113.8 Adult Carcass    50.3 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    99.95 Larval Midgut    66.5 Larval Hindgut    102.1 Larval Malpighian Tubules    90.6 Larval Fat Body    38.6 Larval Salivary Gland    137.9 Larval Trachea    82.975 Larval Carcass    82.025 Adult Head    53.6 Adult Eye    50.775 Adult Brain    157.7 Adult Thoracic-Abdominal Ganglion    139 Adult Crop    142.5 Adult Midgut    48 Adult Hindgut    89.1 Adult Malpighian Tubules    57.5 Adult Fat Body    45 Adult Salivary Gland    269.1 Adult Heart    67.675 Adult VirginFemale Spermatheca    75.1 Adult InseminatedFemale Spermatheca    72.4 Adult Ovary    109.8 Adult Testis    49.1 Adult Male Accessory Gland    113.8 Adult Carcass    50.3 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    99.95 Larval Midgut    66.5 Larval Hindgut    102.1 Larval Malpighian Tubules    90.6 Larval Fat Body    38.6 Larval Salivary Gland    137.9 Larval Trachea    82.975 Larval Carcass    82.025 Adult Head    53.6 Adult Eye    50.775 Adult Brain    157.7 Adult Thoracic-Abdominal Ganglion    139 Adult Crop    142.5 Adult Midgut    48 Adult Hindgut    89.1 Adult Malpighian Tubules    57.5 Adult Fat Body    45 Adult Salivary Gland    269.1 Adult Heart    67.675 Adult VirginFemale Spermatheca    75.1 Adult InseminatedFemale Spermatheca    72.4 Adult Ovary    109.8 Adult Testis    49.1 Adult Male Accessory Gland    113.8 Adult Carcass    50.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    99.95 Larval Midgut    66.5 Larval Hindgut    102.1 Larval Malpighian Tubules    90.6 Larval Fat Body    38.6 Larval Salivary Gland    137.9 Larval Trachea    82.975 Larval Carcass    82.025 Adult Head    53.6 Adult Eye    50.775 Adult Brain    157.7 Adult Thoracic-Abdominal Ganglion    139 Adult Crop    142.5 Adult Midgut    48 Adult Hindgut    89.1 Adult Malpighian Tubules    57.5 Adult Fat Body    45 Adult Salivary Gland    269.1 Adult Heart    67.675 Adult VirginFemale Spermatheca    75.1 Adult InseminatedFemale Spermatheca    72.4 Adult Ovary    109.8 Adult Testis    49.1 Adult Male Accessory Gland    113.8 Adult Carcass    50.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    99.95 Larval Midgut    66.5 Larval Hindgut    102.1 Larval Malpighian Tubules    90.6 Larval Fat Body    38.6 Larval Salivary Gland    137.9 Larval Trachea    82.975 Larval Carcass    82.025 Adult Head    53.6 Adult Eye    50.775 Adult Brain    157.7 Adult Thoracic-Abdominal Ganglion    139 Adult Crop    142.5 Adult Midgut    48 Adult Hindgut    89.1 Adult Malpighian Tubules    57.5 Adult Fat Body    45 Adult Salivary Gland    269.1 Adult Heart    67.675 Adult VirginFemale Spermatheca    75.1 Adult InseminatedFemale Spermatheca    72.4 Adult Ovary    109.8 Adult Testis    49.1 Adult Male Accessory Gland    113.8 Adult Carcass    50.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    53.6   NA  Eye    50.775   NA  Brain    157.7   99.95  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    139   NA  Crop    142.5   66.5  Midgut    48   102.1  Hindgut    89.1   90.6  Malpighian Tubules    57.5   38.6  Fat Body    45   137.9  Salivary Gland    269.1   NA  Heart    67.675   82.975  Trachea    NA   NA  VirginFemale Spermatheca    75.1   NA  InseminatedFemale Spermatheca    72.4   NA  Ovary    109.8   NA  Testis    49.1   NA  Male Accessory Gland    113.8   82.025  Carcass    50.3 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    27 central nervous system, larvae L3    38 central nervous system, pupae P8    32 head, virgin 1-day female    16 head, virgin 4-day female    14 head, virgin 20-day female    11 head, mated 1-day female    15 head, mated 4-day female    16 head, mated 20-day female    12 head, mated 1-day male    21 head, mated 4-day male    22 head, mated 20-day male    25 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    16 digestive system, 4-day adult    17 digestive system, 20-day adult    20 fat body, larvae L3 wandering    10 fat body, white prepupae    13 fat body, pupae P8    20 carcass, larvae L3 wandering    25 carcass, 1-day adult    12 carcass, 4-day adult    14 carcass, 20-day adult    12 ovary, virgin 4-day female    34 ovary, mated 4-day female    45 testis, mated 4-day male    29 accessory gland, mated 4-day male    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (27) central nervous system, larvae L3  (38) central nervous system, pupae P8  (32) head, virgin 1-day female    16 head, virgin 4-day female    14 head, virgin 20-day female    11 head, mated 1-day female    15 head, mated 4-day female    16 head, mated 20-day female    12 head, mated 1-day male    21 head, mated 4-day male    22 head, mated 20-day male    25 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    16 digestive system, 4-day adult    17 digestive system, 20-day adult    20 fat body, larvae L3 wandering    10 fat body, white prepupae    13 fat body, pupae P8    20 carcass, larvae L3 wandering    25 carcass, 1-day adult    12 carcass, 4-day adult    14 carcass, 20-day adult    12 ovary, virgin 4-day female  (34) ovary, mated 4-day female  (45) testis, mated 4-day male  (29) accessory gland, mated 4-day male    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    27 central nervous system, larvae L3    38 central nervous system, pupae P8    32 head, virgin 1-day female    16 head, virgin 4-day female    14 head, virgin 20-day female    11 head, mated 1-day female    15 head, mated 4-day female    16 head, mated 20-day female    12 head, mated 1-day male    21 head, mated 4-day male    22 head, mated 20-day male    25 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    16 digestive system, 4-day adult    17 digestive system, 20-day adult    20 fat body, larvae L3 wandering    10 fat body, white prepupae    13 fat body, pupae P8    20 carcass, larvae L3 wandering    25 carcass, 1-day adult    12 carcass, 4-day adult    14 carcass, 20-day adult    12 ovary, virgin 4-day female    34 ovary, mated 4-day female    45 testis, mated 4-day male    29 accessory gland, mated 4-day male    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    27 central nervous system, larvae L3    38 central nervous system, pupae P8    32 head, virgin 1-day female    16 head, virgin 4-day female    14 head, virgin 20-day female    11 head, mated 1-day female    15 head, mated 4-day female    16 head, mated 20-day female    12 head, mated 1-day male    21 head, mated 4-day male    22 head, mated 20-day male    25 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    16 digestive system, 4-day adult    17 digestive system, 20-day adult    20 fat body, larvae L3 wandering    10 fat body, white prepupae    13 fat body, pupae P8    20 carcass, larvae L3 wandering    25 carcass, 1-day adult    12 carcass, 4-day adult    14 carcass, 20-day adult    12 ovary, virgin 4-day female    34 ovary, mated 4-day female    45 testis, mated 4-day male    29 accessory gland, mated 4-day male    15 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    27 central nervous system, larvae L3    38 central nervous system, pupae P8    32 head, virgin 1-day female    16 head, virgin 4-day female    14 head, virgin 20-day female    11 head, mated 1-day female    15 head, mated 4-day female    16 head, mated 20-day female    12 head, mated 1-day male    21 head, mated 4-day male    22 head, mated 20-day male    25 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    16 digestive system, 4-day adult    17 digestive system, 20-day adult    20 fat body, larvae L3 wandering    10 fat body, white prepupae    13 fat body, pupae P8    20 carcass, larvae L3 wandering    25 carcass, 1-day adult    12 carcass, 4-day adult    14 carcass, 20-day adult    12 ovary, virgin 4-day female    34 ovary, mated 4-day female    45 testis, mated 4-day male    29 accessory gland, mated 4-day male    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  27 central nervous system, larvae L3  (38) central nervous system, pupae P8  32 head, virgin 1-day female    16 head, virgin 4-day female    14 head, virgin 20-day female    11 head, mated 1-day female    15 head, mated 4-day female    16 head, mated 20-day female    12 head, mated 1-day male    21 head, mated 4-day male    22 head, mated 20-day male    25 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    16 digestive system, 4-day adult    17 digestive system, 20-day adult    20 fat body, larvae L3 wandering    10 fat body, white prepupae    13 fat body, pupae P8    20 carcass, larvae L3 wandering    25 carcass, 1-day adult    12 carcass, 4-day adult    14 carcass, 20-day adult    12 ovary, virgin 4-day female  (34) ovary, mated 4-day female  (45) testis, mated 4-day male  29 accessory gland, mated 4-day male    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    27 central nervous system, larvae L3    38 central nervous system, pupae P8    32 head, virgin 1-day female    16 head, virgin 4-day female    14 head, virgin 20-day female    11 head, mated 1-day female    15 head, mated 4-day female    16 head, mated 20-day female    12 head, mated 1-day male    21 head, mated 4-day male    22 head, mated 20-day male    25 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    16 digestive system, 4-day adult    17 digestive system, 20-day adult    20 fat body, larvae L3 wandering    10 fat body, white prepupae    13 fat body, pupae P8    20 carcass, larvae L3 wandering    25 carcass, 1-day adult    12 carcass, 4-day adult    14 carcass, 20-day adult    12 ovary, virgin 4-day female    34 ovary, mated 4-day female    45 testis, mated 4-day male    29 accessory gland, mated 4-day male    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    27 central nervous system, larvae L3    38 central nervous system, pupae P8    32 head, virgin 1-day female    16 head, virgin 4-day female    14 head, virgin 20-day female    11 head, mated 1-day female    15 head, mated 4-day female    16 head, mated 20-day female    12 head, mated 1-day male    21 head, mated 4-day male    22 head, mated 20-day male    25 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    16 digestive system, 4-day adult    17 digestive system, 20-day adult    20 fat body, larvae L3 wandering    10 fat body, white prepupae    13 fat body, pupae P8    20 carcass, larvae L3 wandering    25 carcass, 1-day adult    12 carcass, 4-day adult    14 carcass, 20-day adult    12 ovary, virgin 4-day female    34 ovary, mated 4-day female    45 testis, mated 4-day male    29 accessory gland, mated 4-day male    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    51 embryo 02-04hr    32 embryo 04-06hr    25 embryo 06-08hr    33 embryo 08-10hr    31 embryo 10-12hr    32 embryo 12-14hr    19 embryo 14-16hr    25 embryo 16-18hr    18 embryo 18-20hr    18 embryo 20-22hr    16 embryo 22-24hr    12 larva L1    23 larva L2    15 larva L3 12hr old    15 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    19 white prepupae new    21 white prepupae 12hr    24 white prepupae 24hr    27 pupae 2d postWPP    18 pupae 3d postWPP    14 pupae 4d postWPP    20 adult male 01day    16 adult male 05day    20 adult male 30day    20 adult female 01day    33 adult female 05day    33 adult female 30day    34 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (51) embryo 02-04hr  (32) embryo 04-06hr    25 embryo 06-08hr  (33) embryo 08-10hr  (31) embryo 10-12hr  (32) embryo 12-14hr    19 embryo 14-16hr    25 embryo 16-18hr    18 embryo 18-20hr    18 embryo 20-22hr    16 embryo 22-24hr    12 larva L1    23 larva L2    15 larva L3 12hr old    15 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    19 white prepupae new    21 white prepupae 12hr    24 white prepupae 24hr  (27) pupae 2d postWPP    18 pupae 3d postWPP    14 pupae 4d postWPP    20 adult male 01day    16 adult male 05day    20 adult male 30day    20 adult female 01day  (33) adult female 05day  (33) adult female 30day  (34) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    51 embryo 02-04hr    32 embryo 04-06hr    25 embryo 06-08hr    33 embryo 08-10hr    31 embryo 10-12hr    32 embryo 12-14hr    19 embryo 14-16hr    25 embryo 16-18hr    18 embryo 18-20hr    18 embryo 20-22hr    16 embryo 22-24hr    12 larva L1    23 larva L2    15 larva L3 12hr old    15 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    19 white prepupae new    21 white prepupae 12hr    24 white prepupae 24hr    27 pupae 2d postWPP    18 pupae 3d postWPP    14 pupae 4d postWPP    20 adult male 01day    16 adult male 05day    20 adult male 30day    20 adult female 01day    33 adult female 05day    33 adult female 30day    34 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    51 embryo 02-04hr    32 embryo 04-06hr    25 embryo 06-08hr    33 embryo 08-10hr    31 embryo 10-12hr    32 embryo 12-14hr    19 embryo 14-16hr    25 embryo 16-18hr    18 embryo 18-20hr    18 embryo 20-22hr    16 embryo 22-24hr    12 larva L1    23 larva L2    15 larva L3 12hr old    15 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    19 white prepupae new    21 white prepupae 12hr    24 white prepupae 24hr    27 pupae 2d postWPP    18 pupae 3d postWPP    14 pupae 4d postWPP    20 adult male 01day    16 adult male 05day    20 adult male 30day    20 adult female 01day    33 adult female 05day    33 adult female 30day    34 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    51 embryo 02-04hr    32 embryo 04-06hr    25 embryo 06-08hr    33 embryo 08-10hr    31 embryo 10-12hr    32 embryo 12-14hr    19 embryo 14-16hr    25 embryo 16-18hr    18 embryo 18-20hr    18 embryo 20-22hr    16 embryo 22-24hr    12 larva L1    23 larva L2    15 larva L3 12hr old    15 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    19 white prepupae new    21 white prepupae 12hr    24 white prepupae 24hr    27 pupae 2d postWPP    18 pupae 3d postWPP    14 pupae 4d postWPP    20 adult male 01day    16 adult male 05day    20 adult male 30day    20 adult female 01day    33 adult female 05day    33 adult female 30day    34 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (51) embryo 02-04hr  32 embryo 04-06hr    25 embryo 06-08hr  (33) embryo 08-10hr  31 embryo 10-12hr  32 embryo 12-14hr    19 embryo 14-16hr    25 embryo 16-18hr    18 embryo 18-20hr    18 embryo 20-22hr    16 embryo 22-24hr    12 larva L1    23 larva L2    15 larva L3 12hr old    15 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    19 white prepupae new    21 white prepupae 12hr    24 white prepupae 24hr  27 pupae 2d postWPP    18 pupae 3d postWPP    14 pupae 4d postWPP    20 adult male 01day    16 adult male 05day    20 adult male 30day    20 adult female 01day  (33) adult female 05day  (33) adult female 30day  (34) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    51 embryo 02-04hr    32 embryo 04-06hr    25 embryo 06-08hr    33 embryo 08-10hr    31 embryo 10-12hr    32 embryo 12-14hr    19 embryo 14-16hr    25 embryo 16-18hr    18 embryo 18-20hr    18 embryo 20-22hr    16 embryo 22-24hr    12 larva L1    23 larva L2    15 larva L3 12hr old    15 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    19 white prepupae new    21 white prepupae 12hr    24 white prepupae 24hr    27 pupae 2d postWPP    18 pupae 3d postWPP    14 pupae 4d postWPP    20 adult male 01day    16 adult male 05day    20 adult male 30day    20 adult female 01day    33 adult female 05day    33 adult female 30day    34 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    51 embryo 02-04hr    32 embryo 04-06hr    25 embryo 06-08hr    33 embryo 08-10hr    31 embryo 10-12hr    32 embryo 12-14hr    19 embryo 14-16hr    25 embryo 16-18hr    18 embryo 18-20hr    18 embryo 20-22hr    16 embryo 22-24hr    12 larva L1    23 larva L2    15 larva L3 12hr old    15 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    19 white prepupae new    21 white prepupae 12hr    24 white prepupae 24hr    27 pupae 2d postWPP    18 pupae 3d postWPP    14 pupae 4d postWPP    20 adult male 01day    16 adult male 05day    20 adult male 30day    20 adult female 01day    33 adult female 05day    33 adult female 30day    34 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    63 Schneider line 2 Sg4    63 embryonic 1182-4H    82 embryonic GM2    39 embryonic Kc167    28 embryonic S1    46 embryonic S3    31 leg disc CME L1    78 wing disc CME-W2    30 wing disc ML-DmD8    35 wing disc ML-DmD9    63 wing disc ML-DmD16-c3    60 wing disc ML-DmD21    70 wing disc ML-DmD32    77 haltere disc ML-DmD17-c3    47 eye-antennal disc ML-DmD11    42 antennal disc ML-DmD20-c5    48 mixed discs ML-DmD4-c1    49 CNS ML-DmBG1-c1    63 CNS ML-DmBG2-c2    25 tumorous blood cells mbn2    34 ovary fGS/OSS    82 ovary OSC    37 ovary OSS    32 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (63) Schneider line 2 Sg4  (63) embryonic 1182-4H  (82) embryonic GM2  (39) embryonic Kc167  (28) embryonic S1  (46) embryonic S3  (31) leg disc CME L1  (78) wing disc CME-W2  (30) wing disc ML-DmD8  (35) wing disc ML-DmD9  (63) wing disc ML-DmD16-c3  (60) wing disc ML-DmD21  (70) wing disc ML-DmD32  (77) haltere disc ML-DmD17-c3  (47) eye-antennal disc ML-DmD11  (42) antennal disc ML-DmD20-c5  (48) mixed discs ML-DmD4-c1  (49) CNS ML-DmBG1-c1  (63) CNS ML-DmBG2-c2    25 tumorous blood cells mbn2  (34) ovary fGS/OSS  (82) ovary OSC  (37) ovary OSS  (32) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    63 Schneider line 2 Sg4    63 embryonic 1182-4H    82 embryonic GM2    39 embryonic Kc167    28 embryonic S1    46 embryonic S3    31 leg disc CME L1    78 wing disc CME-W2    30 wing disc ML-DmD8    35 wing disc ML-DmD9    63 wing disc ML-DmD16-c3    60 wing disc ML-DmD21    70 wing disc ML-DmD32    77 haltere disc ML-DmD17-c3    47 eye-antennal disc ML-DmD11    42 antennal disc ML-DmD20-c5    48 mixed discs ML-DmD4-c1    49 CNS ML-DmBG1-c1    63 CNS ML-DmBG2-c2    25 tumorous blood cells mbn2    34 ovary fGS/OSS    82 ovary OSC    37 ovary OSS    32 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    63 Schneider line 2 Sg4    63 embryonic 1182-4H    82 embryonic GM2    39 embryonic Kc167    28 embryonic S1    46 embryonic S3    31 leg disc CME L1    78 wing disc CME-W2    30 wing disc ML-DmD8    35 wing disc ML-DmD9    63 wing disc ML-DmD16-c3    60 wing disc ML-DmD21    70 wing disc ML-DmD32    77 haltere disc ML-DmD17-c3    47 eye-antennal disc ML-DmD11    42 antennal disc ML-DmD20-c5    48 mixed discs ML-DmD4-c1    49 CNS ML-DmBG1-c1    63 CNS ML-DmBG2-c2    25 tumorous blood cells mbn2    34 ovary fGS/OSS    82 ovary OSC    37 ovary OSS    32 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    63 Schneider line 2 Sg4    63 embryonic 1182-4H    82 embryonic GM2    39 embryonic Kc167    28 embryonic S1    46 embryonic S3    31 leg disc CME L1    78 wing disc CME-W2    30 wing disc ML-DmD8    35 wing disc ML-DmD9    63 wing disc ML-DmD16-c3    60 wing disc ML-DmD21    70 wing disc ML-DmD32    77 haltere disc ML-DmD17-c3    47 eye-antennal disc ML-DmD11    42 antennal disc ML-DmD20-c5    48 mixed discs ML-DmD4-c1    49 CNS ML-DmBG1-c1    63 CNS ML-DmBG2-c2    25 tumorous blood cells mbn2    34 ovary fGS/OSS    82 ovary OSC    37 ovary OSS    32 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (63) Schneider line 2 Sg4  (63) embryonic 1182-4H  (82) embryonic GM2  (39) embryonic Kc167  28 embryonic S1  (46) embryonic S3  31 leg disc CME L1  (78) wing disc CME-W2  30 wing disc ML-DmD8  (35) wing disc ML-DmD9  (63) wing disc ML-DmD16-c3  (60) wing disc ML-DmD21  (70) wing disc ML-DmD32  (77) haltere disc ML-DmD17-c3  (47) eye-antennal disc ML-DmD11  (42) antennal disc ML-DmD20-c5  (48) mixed discs ML-DmD4-c1  (49) CNS ML-DmBG1-c1  (63) CNS ML-DmBG2-c2    25 tumorous blood cells mbn2  (34) ovary fGS/OSS  (82) ovary OSC  (37) ovary OSS  32 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    63 Schneider line 2 Sg4    63 embryonic 1182-4H    82 embryonic GM2    39 embryonic Kc167    28 embryonic S1    46 embryonic S3    31 leg disc CME L1    78 wing disc CME-W2    30 wing disc ML-DmD8    35 wing disc ML-DmD9    63 wing disc ML-DmD16-c3    60 wing disc ML-DmD21    70 wing disc ML-DmD32    77 haltere disc ML-DmD17-c3    47 eye-antennal disc ML-DmD11    42 antennal disc ML-DmD20-c5    48 mixed discs ML-DmD4-c1    49 CNS ML-DmBG1-c1    63 CNS ML-DmBG2-c2    25 tumorous blood cells mbn2    34 ovary fGS/OSS    82 ovary OSC    37 ovary OSS    32 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    63 Schneider line 2 Sg4    63 embryonic 1182-4H    82 embryonic GM2    39 embryonic Kc167    28 embryonic S1    46 embryonic S3    31 leg disc CME L1    78 wing disc CME-W2    30 wing disc ML-DmD8    35 wing disc ML-DmD9    63 wing disc ML-DmD16-c3    60 wing disc ML-DmD21    70 wing disc ML-DmD32    77 haltere disc ML-DmD17-c3    47 eye-antennal disc ML-DmD11    42 antennal disc ML-DmD20-c5    48 mixed discs ML-DmD4-c1    49 CNS ML-DmBG1-c1    63 CNS ML-DmBG2-c2    25 tumorous blood cells mbn2    34 ovary fGS/OSS    82 ovary OSC    37 ovary OSS    32 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    37 cold shock, 4-day adult    29 heat shock, 4-day adult    26 Cadmium 50 mM 6 hrs, larvae L3    15 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    20 Cadmium 100 mM 48 hrs, 4-day adult    30 Copper 0.5 mM 12 hrs, larvae L3    37 Copper 15 mM 48 hrs, 4-day adult    12 Zinc 5 mM 12 hrs, larvae L3    19 Zinc 4.5 mM 48 hrs, 4-day adult    19 Ethanol 2.5% 3 hrs, larvae L3    39 Ethanol 5% 3 hrs, larvae L3    10 Ethanol 10% 3 hrs, larvae L3    14 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    26 Caffeine 25 mg/ml 48 hrs, 4-day adult    32 Paraquat 5 mM 48 hrs, 4-day adult    30 Paraquat 10 mM 48 hrs, 4-day adult    38 Rotenone 2 μg 12 hrs, larvae L3    13 Rotenone 8 μg 12 hrs, larvae L3    16 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (37) cold shock, 4-day adult  (29) heat shock, 4-day adult  26 Cadmium 50 mM 6 hrs, larvae L3    15 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    20 Cadmium 100 mM 48 hrs, 4-day adult  (30) Copper 0.5 mM 12 hrs, larvae L3  (37) Copper 15 mM 48 hrs, 4-day adult    12 Zinc 5 mM 12 hrs, larvae L3    19 Zinc 4.5 mM 48 hrs, 4-day adult    19 Ethanol 2.5% 3 hrs, larvae L3  (39) Ethanol 5% 3 hrs, larvae L3    10 Ethanol 10% 3 hrs, larvae L3    14 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  26 Caffeine 25 mg/ml 48 hrs, 4-day adult  (32) Paraquat 5 mM 48 hrs, 4-day adult  (30) Paraquat 10 mM 48 hrs, 4-day adult  (38) Rotenone 2 μg 12 hrs, larvae L3    13 Rotenone 8 μg 12 hrs, larvae L3    16 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    37 cold shock, 4-day adult    29 heat shock, 4-day adult    26 Cadmium 50 mM 6 hrs, larvae L3    15 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    20 Cadmium 100 mM 48 hrs, 4-day adult    30 Copper 0.5 mM 12 hrs, larvae L3    37 Copper 15 mM 48 hrs, 4-day adult    12 Zinc 5 mM 12 hrs, larvae L3    19 Zinc 4.5 mM 48 hrs, 4-day adult    19 Ethanol 2.5% 3 hrs, larvae L3    39 Ethanol 5% 3 hrs, larvae L3    10 Ethanol 10% 3 hrs, larvae L3    14 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    26 Caffeine 25 mg/ml 48 hrs, 4-day adult    32 Paraquat 5 mM 48 hrs, 4-day adult    30 Paraquat 10 mM 48 hrs, 4-day adult    38 Rotenone 2 μg 12 hrs, larvae L3    13 Rotenone 8 μg 12 hrs, larvae L3    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    37 cold shock, 4-day adult    29 heat shock, 4-day adult    26 Cadmium 50 mM 6 hrs, larvae L3    15 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    20 Cadmium 100 mM 48 hrs, 4-day adult    30 Copper 0.5 mM 12 hrs, larvae L3    37 Copper 15 mM 48 hrs, 4-day adult    12 Zinc 5 mM 12 hrs, larvae L3    19 Zinc 4.5 mM 48 hrs, 4-day adult    19 Ethanol 2.5% 3 hrs, larvae L3    39 Ethanol 5% 3 hrs, larvae L3    10 Ethanol 10% 3 hrs, larvae L3    14 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    26 Caffeine 25 mg/ml 48 hrs, 4-day adult    32 Paraquat 5 mM 48 hrs, 4-day adult    30 Paraquat 10 mM 48 hrs, 4-day adult    38 Rotenone 2 μg 12 hrs, larvae L3    13 Rotenone 8 μg 12 hrs, larvae L3    16 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    37 cold shock, 4-day adult    29 heat shock, 4-day adult    26 Cadmium 50 mM 6 hrs, larvae L3    15 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    20 Cadmium 100 mM 48 hrs, 4-day adult    30 Copper 0.5 mM 12 hrs, larvae L3    37 Copper 15 mM 48 hrs, 4-day adult    12 Zinc 5 mM 12 hrs, larvae L3    19 Zinc 4.5 mM 48 hrs, 4-day adult    19 Ethanol 2.5% 3 hrs, larvae L3    39 Ethanol 5% 3 hrs, larvae L3    10 Ethanol 10% 3 hrs, larvae L3    14 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    26 Caffeine 25 mg/ml 48 hrs, 4-day adult    32 Paraquat 5 mM 48 hrs, 4-day adult    30 Paraquat 10 mM 48 hrs, 4-day adult    38 Rotenone 2 μg 12 hrs, larvae L3    13 Rotenone 8 μg 12 hrs, larvae L3    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (37) cold shock, 4-day adult  29 heat shock, 4-day adult  26 Cadmium 50 mM 6 hrs, larvae L3    15 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    20 Cadmium 100 mM 48 hrs, 4-day adult  30 Copper 0.5 mM 12 hrs, larvae L3  (37) Copper 15 mM 48 hrs, 4-day adult    12 Zinc 5 mM 12 hrs, larvae L3    19 Zinc 4.5 mM 48 hrs, 4-day adult    19 Ethanol 2.5% 3 hrs, larvae L3  (39) Ethanol 5% 3 hrs, larvae L3    10 Ethanol 10% 3 hrs, larvae L3    14 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  26 Caffeine 25 mg/ml 48 hrs, 4-day adult  32 Paraquat 5 mM 48 hrs, 4-day adult  30 Paraquat 10 mM 48 hrs, 4-day adult  (38) Rotenone 2 μg 12 hrs, larvae L3    13 Rotenone 8 μg 12 hrs, larvae L3    16 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    37 cold shock, 4-day adult    29 heat shock, 4-day adult    26 Cadmium 50 mM 6 hrs, larvae L3    15 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    20 Cadmium 100 mM 48 hrs, 4-day adult    30 Copper 0.5 mM 12 hrs, larvae L3    37 Copper 15 mM 48 hrs, 4-day adult    12 Zinc 5 mM 12 hrs, larvae L3    19 Zinc 4.5 mM 48 hrs, 4-day adult    19 Ethanol 2.5% 3 hrs, larvae L3    39 Ethanol 5% 3 hrs, larvae L3    10 Ethanol 10% 3 hrs, larvae L3    14 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    26 Caffeine 25 mg/ml 48 hrs, 4-day adult    32 Paraquat 5 mM 48 hrs, 4-day adult    30 Paraquat 10 mM 48 hrs, 4-day adult    38 Rotenone 2 μg 12 hrs, larvae L3    13 Rotenone 8 μg 12 hrs, larvae L3    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    37 cold shock, 4-day adult    29 heat shock, 4-day adult    26 Cadmium 50 mM 6 hrs, larvae L3    15 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    20 Cadmium 100 mM 48 hrs, 4-day adult    30 Copper 0.5 mM 12 hrs, larvae L3    37 Copper 15 mM 48 hrs, 4-day adult    12 Zinc 5 mM 12 hrs, larvae L3    19 Zinc 4.5 mM 48 hrs, 4-day adult    19 Ethanol 2.5% 3 hrs, larvae L3    39 Ethanol 5% 3 hrs, larvae L3    10 Ethanol 10% 3 hrs, larvae L3    14 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    26 Caffeine 25 mg/ml 48 hrs, 4-day adult    32 Paraquat 5 mM 48 hrs, 4-day adult    30 Paraquat 10 mM 48 hrs, 4-day adult    38 Rotenone 2 μg 12 hrs, larvae L3    13 Rotenone 8 μg 12 hrs, larvae L3    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_13 mE1_20_mRNA_expression_cluster_09
External Data & Images
Linkouts	BDGP expression data • LD28657 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0027497 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1098-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | third instar larval stage Madm3T4 partially lethal - majority die | pupal stage Madm2U3 partially lethal - majority die | third instar larval stage Madm2U3 viable, with Scer\GAL4pnr-MD237 MadmGD7155 Other Phenotypes Allele developmental rate defective Madm2D2 Madm2U3 Madm3G5 Madm3T4 Madm3Y2 Madm4S3 Madm7L2 visible, with Scer\GAL4pnr-MD237 MadmGD7155 Phenotype manifest in Allele eye | cell autonomous | somatic clone Madm2U3 Madm3G5 Madm3Y2 Madm7L2 head | larval stage Madm3T4 Madm2U3 Madm4S3 Madm3G5 Madm3Y2 Madm7L2 Madm2D2 ommatidium | cell autonomous | somatic clone Madm2U3 Madm3G5 Madm3Y2 Madm7L2 photoreceptor cell | cell autonomous | somatic clone Madm2U3 rhabdomere | cell autonomous | somatic clone Madm2U3 Madm3G5 Madm3Y2 Madm7L2 trichogen cell, with Scer\GAL4pnr-MD237 MadmGD7155
Classical Alleles ( 8 )
For All Classical Alleles Show
Allele of Madm Class Mutagen Stocks Known lesion MadmEP3137 P-element activity 1 -- Madm2D2 ethyl methanesulfonate 0 Yes Madm2U3 ethyl methanesulfonate 0 Yes Madm3G5 ethyl methanesulfonate 0 Yes Madm3T4 ethyl methanesulfonate 0 Yes Madm3Y2 ethyl methanesulfonate 0 Yes Madm4S3 ethyl methanesulfonate 0 Yes Madm7L2 ethyl methanesulfonate 0 Yes
Alleles Carried on Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Madm Class Mutagen Stocks Known lesion MadmGD7155 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes MadmGL01135 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes MadmHMJ02096 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes MadmJF01435 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes MadmKK109439 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Madm+t.2240 in vitro construct - genomic fragment 0 Yes MadmScer\UAS.cGa in vitro construct - regulatory fusion 0 Yes MadmScer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes MadmT:SV5\V5 in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6145 (Ryder, 2004.4.26) Df(3R)Exel7283 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD7155} NA P{KK109439} NA P{TRiP.GL01135} NA P{TRiP.HMJ02096} NA P{TRiP.JF01435} NA P{UAS-GFP-Madm.attB} NA P{UAS-Madm.G} NA characterization construct P{Madm+t.2240} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}MadmEP3137 NA
Gene Ontology: Function, Process & Cellular Component ( 9 unique terms )
Terms Based on Experimental Evidence ( 5 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
protein secretion inferred from mutant phenotype (Bard et al., 2006) regulation of cell proliferation inferred from direct assay (Gluderer et al., 2010) regulation of cell size inferred from direct assay (Gluderer et al., 2010)
Cellular Component
CV term Evidence References
cytosol inferred from direct assay (Bard et al., 2006) Golgi apparatus inferred from direct assay (Bard et al., 2006)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR000719 (FlyBase Curators et al., 2004-) NOT protein kinase activity inferred from key residues (Anamika et al., 2009) protein serine/threonine kinase activity inferred from sequence or structural similarity with EMBL:AF080436 (FlyBase, 1992-)
Biological Process
CV term Evidence References
NOT protein phosphorylation inferred from key residues (Anamika et al., 2009)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Madm allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0027497 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40710 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q9Y0Y6
Orthologs
OrthoDB Orthologs (45) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6FR1B7 Dipteran inclusive ortholog search EOG6MSD6J Insect inclusive ortholog search EOG66WX4X Arthropod inclusive ortholog search EOG6SQVC4 Metazoa inclusive ortholog search EOG6TXQK6
Orthologs in Drosophila Species (EOG6FR1B7)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Madm     Drosophila simulans   Dsim\GD19817 Y   Drosophila sechellia   Dsec\GM10837 Y   Drosophila erecta   Dere\GG13012 Y   Drosophila yakuba   Dyak\GE10161 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA10685 Y   Drosophila persimilis   Dper\GL24520 Y   Drosophila willistoni   Dwil\GK13372 Y   Drosophila virilis   Dvir\GJ23327 Y   Drosophila mojavensis   Dmoj\GI22915 Y   Drosophila grimshawi   Dgri\GH18153 Y
Orthologs in non-Drosophila Dipterans (EOG6MSD6J)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL001848   Anopheles gambiae Malaria mosquito  Agam\AGAP007996   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ802099
Orthologs in non-Dipteran Insects (EOG66WX4X)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB44910   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG007902   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH16515   Atta cephalotes Leafcutter ant  Acep\ACEP25365   Atta cephalotes Leafcutter ant  Acep\ACEP21097   Camponotus floridanus Florida carpenter ant  Cflo\CFLO16320   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL17901   Linepithema humile Argentine ant  Lhum\LH20961   Pogonomyrmex barbatus Red harvester ant  Pbar\PB13667   Solenopsis invicta Red fire ant  Sinv\SINV10459   Acyrthosiphon pisum Pea aphid  Apim\ACYPI008954   Acyrthosiphon pisum Pea aphid  Apim\ACYPI083537   Bombyx mori Silkmoth  Bmor\BGIBMGA006676   Pediculus humanus Human body louse  Phum\PHUM000590   Tribolium castaneum Red flour beetle  Tcas\TC012395
Orthologs in non-Insect Arthropods (EOG6SQVC4)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\NS1   Daphnia pulex Water flea  Dpux\JGI_V11_308604   Ixodes scapularis Deer tick  Isca\ISCW014140
Orthologs in non-Arthropod Metazoa (EOG6TXQK6)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\hpo-11   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_020168gn   Danio rerio Zebrafish  Drer\si:dkey-12h9.7   Danio rerio Zebrafish  Drer\nrbp2   Danio rerio Zebrafish  Drer\zgc:194780   Xenopus tropicalis Western clawed frog  Xtro\nrbp1   Gallus gallus Domestic chicken  Ggal\ENSGALG00000000076   Gallus gallus Domestic chicken  Ggal\NRBP1   Mus musculus House mouse  Mmus\Nrbp2   Mus musculus House mouse  Mmus\Nrbp1   Rattus norvegicus Norway rat  Rnor\Nrbp2   Homo sapiens Human  Hsap\NRBP1   Homo sapiens Human  Hsap\NRBP2
Human Orthologs (2)
Gene OMIM HGNC Hsap\NRBP1     Hsap\NRBP2
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD19817 Drosophila sechellia Dsec\GM10837 Drosophila erecta Dere\GG13012 Drosophila yakuba Dyak\GE10161 Drosophila ananassae Dana\GF16346 Drosophila pseudoobscura pseudoobscura Dpse\GA10685 Drosophila persimilis Dper\GL24520 Drosophila willistoni Dwil\GK13372 Drosophila virilis Dvir\GJ23327 Drosophila mojavensis Dmoj\GI22915 Drosophila grimshawi Dgri\GH18153
Stocks & Reagents
Stocks Listed in FlyBase ( 7 )
Bloomington	31644 y1 v1; P{TRiP.JF01435}attP2 42529 y1 v1; P{TRiP.HMJ02096}attP40 17093 w1118; P{EP}MadmEP3137/TM6B, Tb1 41599 y1 sc* v1; P{TRiP.GL01135}attP2/TM3, Sb1
VDRC	v101758 P{KK109439}VIE-260B v27346 w1118; P{GD7155}v27346 v27347 w1118; P{GD7155}v27347
Genomic Clones ( 1 )
	BACR02L23 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 40 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD28657
Other clones	IP20149
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT10131 AT31882 GH12702 HL06503 LD23548 LD25078 LD27136 LP22173 RE14412 RE17419 RE23332 RE73117 RH09727 RH09803 RH24927 RH32749 RH35310 RH37745 SD04534 SD05030 SD06413 SD09269 SD09270 SD14513 SD16931 SD18379 SD21159
Other clones	75281 163247 569479 CK01.58B.F11 EK046824 EK205131 EK267218 EN14955 GM06652 UT01603 UUGC0950
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0027497 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40710
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: BcDNA:LD28657 CG1098 (Zheng, 1999.11) Source for identity of: Madm CG1098 (Wu, 2005.3.7)
Source for database merge of	Source for merge of: Madm anon-WO0118547.406 (FlyBase, 1996-)
Additional comments	Source for merge of Madm anon-WO0118547.406 was sequence comparison (date:051113). (FlyBase, 1996-)
Other Comments
	dsRNA directed against this gene has been used in a screen for genes required for constitutive protein secretion. (Bard et al., 2006) dsRNA directed against Madm inhibits protein secretion in S2 cells, but has no apparent effect on Golgi organisation. (Bard et al., 2006) When expressed together with a 14-3-3ζ, Madm changed the localization of polyQ inclusions from both nuclear and cytoplasmic to mainly cytoplasmic. (Wu et al., 2005) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) Area matching Drosophila EST AA802961 (inverted). This EST forms 816bp contig with EST AA817584. (Davies, 2001.3.15)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_141324 RefSeq (Proteins) • NP_649581 DDBJ / EMBL / GenBank • AA802961 AA950122 AAD38665 AAF51961 AF145690 AQ073773 AX094282 Entrez Gene - A searchable database of RefSeq genes. • 40710 UniProtKB/Swiss-Prot • Q9Y0Y6
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) Protein kinase-like domain (IPR011009) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD28657
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0027497 DRSC - Results from RNAi screens. • FBgn0027497 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0027497 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1098-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0027497 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40710 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40710 modMine - Data generated by the modENCODE project. • FBgn0027497 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q9Y0Y6
Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym	anon-WO0118547.406   BcDNA:LD28657   CG1098 (Bard et al., 2006, Morrison et al., 2000, Qin et al., 2005, Keleman et al., 2009.8.5, Ni et al., 2008, Ni et al., 2010.12.1) dMADM (Wu et al., 2005) Madm (Arancio et al., 2010, Lipatov et al., 2005, Gluderer et al., 2010) MADM (Zhang et al., 2010)
Name Synonym	Mif1 adaptor molecule (Gluderer et al., 2010) MLF1-adaptor molecule (Lim et al., 2002, Wu et al., 2005)
Secondary FlyBase IDs
	FBgn0062034
References ( 32 )
Generate a list of	All references relating to this gene ( 32 )
List References by type	Research paper  ( 10 ) Supplementary material  ( 5 ) Personal communication to FlyBase  ( 8 ) Abstract  ( 1 ) FlyBase analysis  ( 2 ) Curated genome annotation  ( 3 ) Patent  ( 1 ) DNA/RNA sequence record  ( 1 ) Website  ( 1 )
Recent research papers ( 1 )
	Vesala et al., 2012, Insect Mol. Biol. 21(1): 107--118 Cold tolerance and cold-induced modulation of gene expression in two Drosophila virilis group species with different distributions. [FBrf0217233] Show all research papers ...