FB2021_01, released Feb 18, 2021

Gene: Dmel\Madm

Open Close
General Information
Symbol
Dmel\Madm
Species
D. melanogaster
Name
MLF1-adaptor molecule
Annotation Symbol
CG1098
Feature Type
protein_coding_gene
FlyBase ID
FBgn0027497
Gene Model Status
Current
Stock Availability
11 publicly available
Gene Snapshot
Contributions welcome
Other Summaries
Also Known As

lincRNA.S6031

Key Links
Genomic Location
Cytogenetic map
83C2-83C2
Sequence location
3R:5,742,510..5,747,138 [+]
Recombination map

3-47.5

RefSeq locus
NT_033777 REGION:5742510..5747138
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (15 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
enables ATP binding
inferred from electronic annotation with InterPro:IPR000719
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
enables protein homodimerization activity
inferred from sequence or structural similarity with UniProtKB:Q99J45
(assigned by UniProt )
(UniProt Curators, 2002-)
enables protein serine/threonine kinase activity
inferred from biological aspect of ancestor with PANTHER:PTN000357044
(assigned by GO_Central )
(Gaudet et al., 2011)
NOT enables protein kinase activity
inferred from key residues
(Anamika et al., 2009)
Biological Process (7 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
involved_in intestinal stem cell homeostasis
inferred from mutant phenotype
(Nie et al., 2015)
involved_in protein secretion
inferred from mutant phenotype
(Bard et al., 2006)
involved_in regulation of cell population proliferation
inferred from direct assay
(Gluderer et al., 2010)
involved_in regulation of cell size
inferred from direct assay
(Gluderer et al., 2010)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport
inferred from sequence or structural similarity with UniProtKB:Q9UHY1
(assigned by UniProt )
(UniProt Curators, 2002-)
inferred from biological aspect of ancestor with PANTHER:PTN000357046
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in intracellular signal transduction
inferred from biological aspect of ancestor with PANTHER:PTN000357044
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in protein phosphorylation
inferred from biological aspect of ancestor with PANTHER:PTN000357044
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (4 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
located_in cytosol
inferred from direct assay
(Bard et al., 2006)
located_in Golgi apparatus
inferred from direct assay
(Bard et al., 2006)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
located_in cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN000357044
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in endomembrane system
inferred from biological aspect of ancestor with PANTHER:PTN000357046
(assigned by GO_Central )
(Gaudet et al., 2011)
inferred from sequence or structural similarity with UniProtKB:Q9UHY1
(assigned by UniProt )
(UniProt Curators, 2002-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (Q9Y0Y6)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
OTHER CONVENTIONAL PROTEIN KINASE DOMAIN KINASES -
The group of 'other conventional protein kinase domain kinases' consists of kinases with a conventional eukaryotic protein kinase domain that do not fit into any of the other major groups. This grouping is described in FBrf0201870.
PUTATIVE PSEUDOKINASES -
Pseudokinases have a kinase domain but lack key residue(s) classically required for phosphotransfer. Although potentially lacking catalytic activity, pseudokinases may still have roles in signalling cascades and complexes. (Adapted from FBrf0209106, PMID:21074407 and PMID:23863165).
Protein Function (UniProtKB)
May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus.
(UniProt, Q9Y0Y6)
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Madm for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.56

Gene model reviewed during 5.47

Gene model reviewed during 6.03

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Madm-RA
FBtr0078722
NM_141324
3501
637
Madm-RB
FBtr0347493
NM_001316491
3777
637
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Madm-PA
FBpp0078371
70.5
637
4.75
NP_649581
AAF51961
Madm-PB
FBpp0312573
70.5
637
4.75
NP_001303420
ALI30533
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

637 aa isoforms: Madm-PA, Madm-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Domain

The protein kinase domain is predicted to be catalytically inactive.

(UniProt, Q9Y0Y6)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Madm using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | faint | ubiquitous
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
organism | faint | ubiquitous
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 12
organism | faint | ubiquitous
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
spermatogenesis & adult stage | male
somatic cell of testis
(Singh et al., 2016)
adult stage | male & spermatogenesis
cyst progenitor cell
(Singh et al., 2016)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cytosol
inferred from direct assay
(Bard et al., 2006)
located_in Golgi apparatus
inferred from direct assay
(Bard et al., 2006)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Madm in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 10 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 12 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Madm
Transgenic constructs containing regulatory region of Madm
Aberrations (Deficiencies and Duplications) ( 5 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal - all die before end of larval stage
partially lethal - majority die | pupal stage
partially lethal - majority die | third instar larval stage
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
female sterile, with Scer\GAL4VP16.mat.αTub67C
Other Phenotypes
Allele
abnormal cell shape | adult stage, with Scer\GAL4NP5130
abnormal developmental rate
decreased cell number | adult stage, with Scer\GAL4NP5130
decreased cell number | adult stage | somatic clone
decreased occurrence of cell division | adult stage, with Scer\GAL4Dl.PU
decreased occurrence of cell division | adult stage, with Scer\GAL4NP5130
short lived | heat sensitive, with Scer\GAL4tin.CΔ4
some die during third instar larval stage
visible, with Scer\GAL4pnr-MD237
Phenotype manifest in
Allele
adult midgut, with Scer\GAL4Dl.PU
adult midgut, with Scer\GAL4NP5130
embryo | maternal effect, with Scer\GAL4VP16.mat.αTub67C
enteroblast | adult stage, with Scer\GAL4NP5130
enteroendocrine cell | adult stage, with Scer\GAL4NP5130
eye | cell autonomous | somatic clone
head | larval stage
intestinal stem cell | adult stage, with Scer\GAL4NP5130
intestinal stem cell | adult stage | somatic clone
ommatidium | cell autonomous | somatic clone
photoreceptor cell | cell autonomous | somatic clone
rhabdomere | cell autonomous | somatic clone
trichogen cell, with Scer\GAL4pnr-MD237
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (7)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\NRBP1
15 of 15
Yes
Yes
Hsap\NRBP2
11 of 15
No
Yes
Hsap\MIR6845
2 of 15
No
Yes
Hsap\DSTYK
1 of 15
No
Yes
Hsap\WNK1
1 of 15
No
No
2  
Hsap\WNK3
1 of 15
No
No
1  
Hsap\WNK4
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (6)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Nrbp1
14 of 15
Yes
Yes
Mmus\Nrbp2
11 of 15
No
Yes
Mmus\Dstyk
1 of 15
No
Yes
Mmus\Wnk1
1 of 15
No
No
Mmus\Wnk3
1 of 15
No
No
Mmus\Wnk4
1 of 15
No
No
Rattus norvegicus (Norway rat) (6)
Rnor\Nrbp1
11 of 13
Yes
Yes
Rnor\Nrbp2
11 of 13
Yes
Yes
Rnor\Dstyk
1 of 13
No
Yes
Rnor\Wnk1
1 of 13
No
No
Rnor\Wnk3
1 of 13
No
No
Rnor\Wnk4
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (5)
Xtro\nrbp1
7 of 12
Yes
Yes
Xtro\dstyk
1 of 12
No
Yes
Xtro\nrbp2
1 of 12
No
Yes
Xtro\wnk3
1 of 12
No
No
Xtro\wnk4
1 of 12
No
No
Danio rerio (Zebrafish) (9)
Drer\nrbp1
14 of 15
Yes
Yes
Drer\nrbp2a
11 of 15
No
Yes
Drer\nrbp2b
10 of 15
No
Yes
Drer\dstyk
1 of 15
No
Yes
Drer\LOC101883538
1 of 15
No
No
Drer\si:dkey-151g10.3
1 of 15
No
Yes
Drer\wnk1a
1 of 15
No
No
Drer\wnk1b
1 of 15
No
No
Drer\wnk4b
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (2)
Cele\hpo-11
12 of 15
Yes
Yes
Cele\wnk-1
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (11)
Atha\AT5G55560
2 of 9
Yes
No
Atha\WNK1
2 of 9
Yes
No
Atha\WNK2
2 of 9
Yes
No
Atha\WNK3
2 of 9
Yes
No
Atha\WNK4
2 of 9
Yes
No
Atha\WNK5
2 of 9
Yes
No
Atha\WNK6
2 of 9
Yes
No
Atha\WNK7
2 of 9
Yes
No
Atha\WNK8
2 of 9
Yes
No
Atha\WNK9
2 of 9
Yes
No
Atha\WNK10
2 of 9
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (2)
Scer\CDC5
1 of 15
Yes
No
Scer\SSK2
1 of 15
Yes
No
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091905US )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00012760
Drosophila simulans
Dsim\GD19817
Drosophila sechellia
Dsec\GM10837
Drosophila erecta
Dere\GG13012
Drosophila yakuba
Dyak\GE10161
Drosophila ananassae
Dana\GF16346
Drosophila pseudoobscura pseudoobscura
Dpse\GA10685
Drosophila persimilis
Dper\GL24520
Drosophila willistoni
Dwil\GK13372
Drosophila virilis
Dvir\GJ23327
Drosophila mojavensis
Dmoj\GI22915
Drosophila grimshawi
Dgri\GH18153
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091502A0 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17016823
Glossina morsitans
Tsetse fly
Gmor\GMOY011635
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_00832
Mayetiola destructor
Hessian fly
Mdes\Mdes008813
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL001848
Anopheles darlingi
American malaria mosquito
Adar\ADAC000980
Anopheles gambiae
Malaria mosquito
Agam\AGAP007996
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ000515
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W022Q )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA006676
Danaus plexippus
Monarch butterfly
Dple\DPOGS209609-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL003909
Apis florea
Little honeybee
Aflo\2414975300
Apis mellifera
Western honey bee
Amel\GB44910
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP18508
Bombus terrestris
Buff-tailed bumblebee
Bter\15212541
Linepithema humile
Argentine ant
Lhum\LH20961
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0003eb
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG007902
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_08035
Tribolium castaneum
Red flour beetle
Tcas\TC034317
Pediculus humanus
Human body louse
Phum\PHUM000590
Rhodnius prolixus
Kissing bug
Rpro\RPRC007432
Cimex lectularius
Bed bug
Clec\CLEC003968
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI083537
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_12071
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0208 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR009158
Ixodes scapularis
Black-legged tick
Isca\ISCW014140
Stegodyphus mimosarum
African social velvet spider
Smim\KFM62739.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur20g01450
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_308604
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G031V )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Nrbp
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000007724
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000000076
Gallus gallus
Domestic chicken
Ggal\NRBP1
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (1)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Wnk
3 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Allele
Disease
Evidence
References
Potential Models Based on Orthology ( 0 )
Human Ortholog
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Allele
Disease
Interaction
References
Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
NRBP1; nuclear receptor binding protein 1
15 of 15
606010
      NRBP2; nuclear receptor binding protein 2
      11 of 15
      615563
          Functional Complementation Data
          Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
          Interactions
          Summary of Physical Interactions
          esyN Network Diagram
          Show neighbor-neighbor interactions:
          Select Layout:
          Legend:
          Protein
          RNA
          Selected Interactor(s)
          Interactions Browser
          View in Interactions Browser
          Please see the Physical Interaction reports below for full details
          protein-protein
          Physical Interaction
          Assay
          References
          Madm - bun
          anti tag coimmunoprecipitation, western blot, affinity technology, Identification by mass spectrometry, two hybrid
          (Gluderer et al., 2010)
          Summary of Genetic Interactions
          esyN Network Diagram
          esyN Network Key:
          Suppression
          Enhancement
          View in Interactions Browser
          Please look at the allele data for full details of the genetic interactions
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          Egfr
          suppressible
          Madm
          (Nie et al., 2015)
          gig
          suppressible
          Madm
          (Nie et al., 2015)
          hpo
          suppressible
          Madm
          (Nie et al., 2015)
          InR
          suppressible
          Madm
          (Nie et al., 2015)
          msn
          suppressible
          Madm
          (Nie et al., 2015)
          upd3
          suppressible
          Madm
          (Nie et al., 2015)
          vn
          suppressible
          Madm
          (Nie et al., 2015)
          External Data
          Linkouts
          DroID - A comprehensive database of gene and protein interactions.
          InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
          Pathways
          Signaling Pathways (FlyBase)
          Metabolic Pathways
          External Data
          Linkouts
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          Genomic Location and Detailed Mapping Data
          Chromosome (arm)
          3R
          Recombination map

          3-47.5

          Cytogenetic map
          83C2-83C2
          Sequence location
          3R:5,742,510..5,747,138 [+]
          FlyBase Computed Cytological Location
          Cytogenetic map
          Evidence for location
          83C2-83C2
          Limits computationally determined from genome sequence between P{lacW}casj1C2 and P{PZ}lab01241
          Experimentally Determined Cytological Location
          Cytogenetic map
          Notes
          References
          Experimentally Determined Recombination Data
          Location

          3-47.5

          (FlyBase, 2016)

          3-44.1

          (Comeron et al., 2012)
          Left of (cM)
          Right of (cM)
          Notes
          Stocks and Reagents
          Stocks (11)
          Genomic Clones (14)
           

          Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

          cDNA Clones (49)
           

          Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

          cDNA clones, fully sequenced
          BDGP DGC clones
          Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
          Other clones
          RNAi and Array Information
          Linkouts
          DRSC - Results frm RNAi screens
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          Antibody Information
          Laboratory Generated Antibodies
           
          Commercially Available Antibodies
           
          Other Information
          Relationship to Other Genes
          Source for database identify of

          Source for identity of: BcDNA:LD28657 CG1098

          (Zheng, 1999.11)

          Source for identity of: Madm CG1098

          (Wu, 2005.3.7)
          Source for database merge of

          Source for merge of: Madm anon-WO0118547.406

          (FlyBase, 1996-)
          Additional comments

          Source for merge of Madm anon-WO0118547.406 was sequence comparison ( date:051113 ).

          (FlyBase, 1996-)
          Other Comments

          dsRNA directed against this gene has been used in a screen for genes required for constitutive protein secretion.

          (Bard et al., 2006)

          dsRNA directed against Madm inhibits protein secretion in S2 cells, but has no apparent effect on Golgi organisation.

          (Bard et al., 2006)

          When expressed together with a 14-3-3ζ, Madm changed the localization of polyQ inclusions from both nuclear and cytoplasmic to mainly cytoplasmic.

          (Wu et al., 2005)

          dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

          (Kiger et al., 2003)

          Area matching Drosophila EST AA802961 (inverted). This EST forms 816bp contig with EST AA817584.

          (Davies, 2001.3.15)
          Origin and Etymology
          Discoverer
          Etymology
          Identification
          External Crossreferences and Linkouts ( 36 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
          Other crossreferences
          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          Flygut - An atlas of the Drosophila adult midgut
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
          InterPro - A database of protein families, domains and functional sites
          KEGG Genes - Molecular building blocks of life in the genomic space.
          modMine - A data warehouse for the modENCODE project
          SignaLink - A signaling pathway resource with multi-layered regulatory networks.
          Linkouts
          DroID - A comprehensive database of gene and protein interactions.
          DRSC - Results frm RNAi screens
          FLIGHT - Cell culture data for RNAi and other high-throughput technologies
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
          FlyMine - An integrated database for Drosophila genomics
          InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          Synonyms and Secondary IDs (10)
          Datasets (0)
          Study focus (0)
          Experimental Role
          Project
          Project Type
          Title
          References (55)