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Gene Dmel\CG11092

General Information
Symbol	Dmel\CG11092	Species	D. melanogaster
Name		Annotation symbol	CG11092
Feature type	protein_coding_gene	FlyBase ID	FBgn0027537
Gene Model Status	Current	Stock availability	8 publicly available
Also Known As	nup93
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	12C6-12C6	Sequence location	X:13,716,836..13,719,943 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG11092 (FBgn0027537). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: cellular protein localization; SMAD protein import into nucleus. 7 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; mesothoracic tergum. It has one annotated transcript and one annotated polypeptide. Protein features are: Nucleoporin interacting component Nup93/Nic96. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult heart. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval hindgut, adult Malpighian tubules, larval salivary gland, larval trachea, adult ovary, adult male accessory gland, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1629756_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG11092. Gene sequence location is X:13716836..13719943.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features HFA19344 BKN25863
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 12C6-12C6   Limits computationally determined from genome sequence between P{EP}CG33174EP1101 and P{EP}EP1595EP1595
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG11092 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG11092-RA FBtr0073828  NM_132701   2809   823
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG11092-PA   FBpp0073659   93.9   823   6.20     NP_572929   AAF48327
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Nucleoporin interacting component Nup93/Nic96 (IPR007231)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA263230   AA392311   AA439927   AA735335   AA735336   AA817195   AA817273   AA940589   AA941991   AA942466   AA948866   AA949566   AA950605   AA978451   AA978605   AA979656   AE014298 AAF48327   AF132159 AAD34747   AI061966   AI295732   AI455097   AI456589   AI511804   AI512301   AI512440   AI514668   AI515228   AI518630   AI519161   AI531596   BG638885   BI162961   BI165972   BI167116   BI168350   BI172504   BI173847   BI215653   BI235413   BI239944   BI240447   BI240697   BI241341   BI243224   BI357641   BI362476   BI363872   BI364801   BI365433   BI366071   BI372727   BI484572   BI577940   BI578314   BI580129   BI632857   BI633842   BI636306   BI636838   BI637061   BI641697   CK659582   CO152901   CO185416   CO189526   CO189549   CO266626   CO269410   CO277977   CO281415   CO296874   CO297384   CO299391   CO300254   CO304253   CO308172   CO327491   CO329652   CZ481394   EC082681   EC086177   EC203729   EC206780   EC211518   EC215025   EC221969   EC223032   EC223121   EC228864   EC233077   EC236313   EC239350   EC241041   EC241184   EC243805   EC245566   EC247796   EC248516   EC255739   EC265396   EV600492   GH739985   GH741209   GH744378   GH744670   GH745220   GH762158   GH762350   GH763402   GH764055   GH764927   GH765821
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9XZ06
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0027537    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0027537 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0027537 expression level Developmental Stage   Expression Level embryo 00-02hr    7246 embryo 02-04hr    9078 embryo 04-06hr    6386 embryo 06-08hr    5395 embryo 08-10hr    4847 embryo 10-12hr    3097 embryo 12-14hr    2223 embryo 14-16hr    2648 embryo 16-18hr    2057 embryo 18-20hr    1086 embryo 20-22hr    2887 embryo 22-24hr    2294 larva L1    1529 larva L2    1467 larva L3 12hr old    1159 larva L3 puffstage 1-2    1048 larva L3 puffstage 3-6    1473 larva L3 puffstage 7-9    1589 white prepupae new    1370 white prepupae 12hr    1561 white prepupae 24hr    1673 pupae 2d postWPP    890 pupae 3d postWPP    444 pupae 4d postWPP    565 adult male 01day    523 adult male 05day    719 adult male 30day    710 adult female 01day    2414 adult female 05day    3866 adult female 30day    3983 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (7246) embryo 02-04hr  (9078) embryo 04-06hr  (6386) embryo 06-08hr  (5395) embryo 08-10hr  (4847) embryo 10-12hr  (3097) embryo 12-14hr  (2223) embryo 14-16hr  (2648) embryo 16-18hr  (2057) embryo 18-20hr  (1086) embryo 20-22hr  (2887) embryo 22-24hr  (2294) larva L1  (1529) larva L2  (1467) larva L3 12hr old  (1159) larva L3 puffstage 1-2  (1048) larva L3 puffstage 3-6  (1473) larva L3 puffstage 7-9  (1589) white prepupae new  (1370) white prepupae 12hr  (1561) white prepupae 24hr  (1673) pupae 2d postWPP  (890) pupae 3d postWPP  (444) pupae 4d postWPP  (565) adult male 01day  (523) adult male 05day  (719) adult male 30day  (710) adult female 01day  (2414) adult female 05day  (3866) adult female 30day  (3983) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (7246) embryo 02-04hr  (9078) embryo 04-06hr  (6386) embryo 06-08hr  (5395) embryo 08-10hr  (4847) embryo 10-12hr  (3097) embryo 12-14hr  (2223) embryo 14-16hr  (2648) embryo 16-18hr  (2057) embryo 18-20hr    1086 embryo 20-22hr  (2887) embryo 22-24hr  (2294) larva L1  (1529) larva L2  1467 larva L3 12hr old    1159 larva L3 puffstage 1-2    1048 larva L3 puffstage 3-6  1473 larva L3 puffstage 7-9  (1589) white prepupae new    1370 white prepupae 12hr  (1561) white prepupae 24hr  (1673) pupae 2d postWPP    890 pupae 3d postWPP    444 pupae 4d postWPP    565 adult male 01day    523 adult male 05day    719 adult male 30day    710 adult female 01day  (2414) adult female 05day  (3866) adult female 30day  (3983) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    7246 embryo 02-04hr    9078 embryo 04-06hr    6386 embryo 06-08hr    5395 embryo 08-10hr    4847 embryo 10-12hr    3097 embryo 12-14hr    2223 embryo 14-16hr    2648 embryo 16-18hr    2057 embryo 18-20hr    1086 embryo 20-22hr    2887 embryo 22-24hr    2294 larva L1    1529 larva L2    1467 larva L3 12hr old    1159 larva L3 puffstage 1-2    1048 larva L3 puffstage 3-6    1473 larva L3 puffstage 7-9    1589 white prepupae new    1370 white prepupae 12hr    1561 white prepupae 24hr    1673 pupae 2d postWPP    890 pupae 3d postWPP    444 pupae 4d postWPP    565 adult male 01day    523 adult male 05day    719 adult male 30day    710 adult female 01day    2414 adult female 05day    3866 adult female 30day    3983 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    7246 embryo 02-04hr    9078 embryo 04-06hr    6386 embryo 06-08hr    5395 embryo 08-10hr    4847 embryo 10-12hr    3097 embryo 12-14hr    2223 embryo 14-16hr    2648 embryo 16-18hr    2057 embryo 18-20hr    1086 embryo 20-22hr    2887 embryo 22-24hr    2294 larva L1    1529 larva L2    1467 larva L3 12hr old    1159 larva L3 puffstage 1-2    1048 larva L3 puffstage 3-6    1473 larva L3 puffstage 7-9    1589 white prepupae new    1370 white prepupae 12hr    1561 white prepupae 24hr    1673 pupae 2d postWPP    890 pupae 3d postWPP    444 pupae 4d postWPP    565 adult male 01day    523 adult male 05day    719 adult male 30day    710 adult female 01day    2414 adult female 05day    3866 adult female 30day    3983 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0027537 expression level Developmental Stage   Expression Level embryo 00-02hr    7246 embryo 02-04hr    9078 embryo 04-06hr    6386 embryo 06-08hr    5395 embryo 08-10hr    4847 embryo 10-12hr    3097 embryo 12-14hr    2223 embryo 14-16hr    2648 embryo 16-18hr    2057 embryo 18-20hr    1086 embryo 20-22hr    2887 embryo 22-24hr    2294 larva L1    1529 larva L2    1467 larva L3 12hr old    1159 larva L3 puffstage 1-2    1048 larva L3 puffstage 3-6    1473 larva L3 puffstage 7-9    1589 white prepupae new    1370 white prepupae 12hr    1561 white prepupae 24hr    1673 pupae 2d postWPP    890 pupae 3d postWPP    444 pupae 4d postWPP    565 adult male 01day    523 adult male 05day    719 adult male 30day    710 adult female 01day    2414 adult female 05day    3866 adult female 30day    3983 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (7246) embryo 02-04hr  (9078) embryo 04-06hr  (6386) embryo 06-08hr  (5395) embryo 08-10hr  (4847) embryo 10-12hr  (3097) embryo 12-14hr  (2223) embryo 14-16hr  (2648) embryo 16-18hr  (2057) embryo 18-20hr  (1086) embryo 20-22hr  (2887) embryo 22-24hr  (2294) larva L1  (1529) larva L2  (1467) larva L3 12hr old  (1159) larva L3 puffstage 1-2  (1048) larva L3 puffstage 3-6  (1473) larva L3 puffstage 7-9  (1589) white prepupae new  (1370) white prepupae 12hr  (1561) white prepupae 24hr  (1673) pupae 2d postWPP  (890) pupae 3d postWPP  (444) pupae 4d postWPP  (565) adult male 01day  (523) adult male 05day  (719) adult male 30day  (710) adult female 01day  (2414) adult female 05day  (3866) adult female 30day  (3983) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (7246) embryo 02-04hr  (9078) embryo 04-06hr  (6386) embryo 06-08hr  (5395) embryo 08-10hr  (4847) embryo 10-12hr  (3097) embryo 12-14hr  2223 embryo 14-16hr  (2648) embryo 16-18hr  2057 embryo 18-20hr    1086 embryo 20-22hr  (2887) embryo 22-24hr  2294 larva L1  1529 larva L2  1467 larva L3 12hr old    1159 larva L3 puffstage 1-2    1048 larva L3 puffstage 3-6  1473 larva L3 puffstage 7-9  1589 white prepupae new    1370 white prepupae 12hr  1561 white prepupae 24hr  1673 pupae 2d postWPP    890 pupae 3d postWPP    444 pupae 4d postWPP    565 adult male 01day    523 adult male 05day    719 adult male 30day    710 adult female 01day  2414 adult female 05day  (3866) adult female 30day  (3983) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    7246 embryo 02-04hr    9078 embryo 04-06hr    6386 embryo 06-08hr    5395 embryo 08-10hr    4847 embryo 10-12hr    3097 embryo 12-14hr    2223 embryo 14-16hr    2648 embryo 16-18hr    2057 embryo 18-20hr    1086 embryo 20-22hr    2887 embryo 22-24hr    2294 larva L1    1529 larva L2    1467 larva L3 12hr old    1159 larva L3 puffstage 1-2    1048 larva L3 puffstage 3-6    1473 larva L3 puffstage 7-9    1589 white prepupae new    1370 white prepupae 12hr    1561 white prepupae 24hr    1673 pupae 2d postWPP    890 pupae 3d postWPP    444 pupae 4d postWPP    565 adult male 01day    523 adult male 05day    719 adult male 30day    710 adult female 01day    2414 adult female 05day    3866 adult female 30day    3983 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    7246 embryo 02-04hr    9078 embryo 04-06hr    6386 embryo 06-08hr    5395 embryo 08-10hr    4847 embryo 10-12hr    3097 embryo 12-14hr    2223 embryo 14-16hr    2648 embryo 16-18hr    2057 embryo 18-20hr    1086 embryo 20-22hr    2887 embryo 22-24hr    2294 larva L1    1529 larva L2    1467 larva L3 12hr old    1159 larva L3 puffstage 1-2    1048 larva L3 puffstage 3-6    1473 larva L3 puffstage 7-9    1589 white prepupae new    1370 white prepupae 12hr    1561 white prepupae 24hr    1673 pupae 2d postWPP    890 pupae 3d postWPP    444 pupae 4d postWPP    565 adult male 01day    523 adult male 05day    719 adult male 30day    710 adult female 01day    2414 adult female 05day    3866 adult female 30day    3983 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0027537    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0027537 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult heart. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval hindgut, adult Malpighian tubules, larval salivary gland, larval trachea, adult ovary, adult male accessory gland, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0027537 expression level Tissue   Expression Level Larval Central Nervous System    328.5 Larval Midgut    78.8 Larval Hindgut    135 Larval Malpighian Tubules    76 Larval Fat Body    55.5 Larval Salivary Gland    222.4 Larval Trachea    207.3 Larval Carcass    148.975 Adult Head    63 Adult Eye    44.25 Adult Brain    62.8 Adult Thoracic-Abdominal Ganglion    55.1 Adult Crop    85.9 Adult Midgut    85 Adult Hindgut    94.4 Adult Malpighian Tubules    119.7 Adult Fat Body    94.4 Adult Salivary Gland no informative data Adult Heart    609.275 Adult VirginFemale Spermatheca    59.5 Adult InseminatedFemale Spermatheca    89.4 Adult Ovary    359.9 Adult Testis    87.6 Adult Male Accessory Gland    111.9 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    328.5 Larval Midgut    78.8 Larval Hindgut    135 Larval Malpighian Tubules    76 Larval Fat Body    55.5 Larval Salivary Gland    222.4 Larval Trachea    207.3 Larval Carcass    148.975 Adult Head    63 Adult Eye    44.25 Adult Brain    62.8 Adult Thoracic-Abdominal Ganglion    55.1 Adult Crop    85.9 Adult Midgut    85 Adult Hindgut    94.4 Adult Malpighian Tubules    119.7 Adult Fat Body    94.4 Adult Salivary Gland no informative data Adult Heart  (609.275) Adult VirginFemale Spermatheca    59.5 Adult InseminatedFemale Spermatheca    89.4 Adult Ovary    359.9 Adult Testis    87.6 Adult Male Accessory Gland    111.9 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    328.5 Larval Midgut    78.8 Larval Hindgut    135 Larval Malpighian Tubules    76 Larval Fat Body    55.5 Larval Salivary Gland    222.4 Larval Trachea    207.3 Larval Carcass    148.975 Adult Head    63 Adult Eye    44.25 Adult Brain    62.8 Adult Thoracic-Abdominal Ganglion    55.1 Adult Crop    85.9 Adult Midgut    85 Adult Hindgut    94.4 Adult Malpighian Tubules    119.7 Adult Fat Body    94.4 Adult Salivary Gland no informative data Adult Heart    609.275 Adult VirginFemale Spermatheca    59.5 Adult InseminatedFemale Spermatheca    89.4 Adult Ovary    359.9 Adult Testis    87.6 Adult Male Accessory Gland    111.9 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    328.5 Larval Midgut    78.8 Larval Hindgut    135 Larval Malpighian Tubules    76 Larval Fat Body    55.5 Larval Salivary Gland    222.4 Larval Trachea    207.3 Larval Carcass    148.975 Adult Head    63 Adult Eye    44.25 Adult Brain    62.8 Adult Thoracic-Abdominal Ganglion    55.1 Adult Crop    85.9 Adult Midgut    85 Adult Hindgut    94.4 Adult Malpighian Tubules    119.7 Adult Fat Body    94.4 Adult Salivary Gland no informative data Adult Heart    609.275 Adult VirginFemale Spermatheca    59.5 Adult InseminatedFemale Spermatheca    89.4 Adult Ovary    359.9 Adult Testis    87.6 Adult Male Accessory Gland    111.9 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0027537 expression level Tissue   Expression Level Larval Central Nervous System    328.5 Larval Midgut    78.8 Larval Hindgut    135 Larval Malpighian Tubules    76 Larval Fat Body    55.5 Larval Salivary Gland    222.4 Larval Trachea    207.3 Larval Carcass    148.975 Adult Head    63 Adult Eye    44.25 Adult Brain    62.8 Adult Thoracic-Abdominal Ganglion    55.1 Adult Crop    85.9 Adult Midgut    85 Adult Hindgut    94.4 Adult Malpighian Tubules    119.7 Adult Fat Body    94.4 Adult Salivary Gland no informative data Adult Heart    609.275 Adult VirginFemale Spermatheca    59.5 Adult InseminatedFemale Spermatheca    89.4 Adult Ovary    359.9 Adult Testis    87.6 Adult Male Accessory Gland    111.9 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    328.5 Larval Midgut    78.8 Larval Hindgut    135 Larval Malpighian Tubules    76 Larval Fat Body    55.5 Larval Salivary Gland    222.4 Larval Trachea    207.3 Larval Carcass    148.975 Adult Head    63 Adult Eye    44.25 Adult Brain    62.8 Adult Thoracic-Abdominal Ganglion    55.1 Adult Crop    85.9 Adult Midgut    85 Adult Hindgut    94.4 Adult Malpighian Tubules    119.7 Adult Fat Body    94.4 Adult Salivary Gland no informative data Adult Heart  609.275 Adult VirginFemale Spermatheca    59.5 Adult InseminatedFemale Spermatheca    89.4 Adult Ovary    359.9 Adult Testis    87.6 Adult Male Accessory Gland    111.9 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    328.5 Larval Midgut    78.8 Larval Hindgut    135 Larval Malpighian Tubules    76 Larval Fat Body    55.5 Larval Salivary Gland    222.4 Larval Trachea    207.3 Larval Carcass    148.975 Adult Head    63 Adult Eye    44.25 Adult Brain    62.8 Adult Thoracic-Abdominal Ganglion    55.1 Adult Crop    85.9 Adult Midgut    85 Adult Hindgut    94.4 Adult Malpighian Tubules    119.7 Adult Fat Body    94.4 Adult Salivary Gland no informative data Adult Heart    609.275 Adult VirginFemale Spermatheca    59.5 Adult InseminatedFemale Spermatheca    89.4 Adult Ovary    359.9 Adult Testis    87.6 Adult Male Accessory Gland    111.9 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    328.5 Larval Midgut    78.8 Larval Hindgut    135 Larval Malpighian Tubules    76 Larval Fat Body    55.5 Larval Salivary Gland    222.4 Larval Trachea    207.3 Larval Carcass    148.975 Adult Head    63 Adult Eye    44.25 Adult Brain    62.8 Adult Thoracic-Abdominal Ganglion    55.1 Adult Crop    85.9 Adult Midgut    85 Adult Hindgut    94.4 Adult Malpighian Tubules    119.7 Adult Fat Body    94.4 Adult Salivary Gland no informative data Adult Heart    609.275 Adult VirginFemale Spermatheca    59.5 Adult InseminatedFemale Spermatheca    89.4 Adult Ovary    359.9 Adult Testis    87.6 Adult Male Accessory Gland    111.9 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    63   NA  Eye    44.25   NA  Brain    62.8   328.5  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    55.1   NA  Crop    85.9   78.8  Midgut    85   135  Hindgut    94.4   76  Malpighian Tubules    119.7   55.5  Fat Body    94.4   222.4  Salivary Gland    no informative data   NA  Heart    609.275   207.3  Trachea    NA   NA  VirginFemale Spermatheca    59.5   NA  InseminatedFemale Spermatheca    89.4   NA  Ovary    359.9   NA  Testis    87.6   NA  Male Accessory Gland    111.9   148.975  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_17
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0027537 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11092-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | pupal stage, with Scer\GAL4pnr-MD237 CG11092GD7196 Other Phenotypes Allele visible, with Scer\GAL4pnr-MD237 CG11092GD7196 Phenotype manifest in Allele mesothoracic tergum, with Scer\GAL4pnr-MD237 CG11092GD7196 trichogen cell, with Scer\GAL4pnr-MD237 CG11092GD7196
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of CG11092 Class Mutagen Stocks Known lesion CG11092e03640 piggyBac transposase 1 -- CG11092G9996 P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG11092 Class Mutagen Stocks Known lesion CG11092GD7196 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes CG11092HMS00850 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG11092HMS00898 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG11092JF01712 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG11092KK105863 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD7196} NA P{KK105863} NA P{TRiP.HMS00850} NA P{TRiP.HMS00898} NA P{TRiP.JF01712} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{SUPor-P}ClicKG05667 NA PBac{RB}CG11092e03640 NA insertion of mobile activating element P{EP}CG11092G9996 NA
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
cellular protein localization inferred from mutant phenotype (Chen and Xu, 2010) NOT NLS-bearing substrate import into nucleus inferred from mutant phenotype (Chen and Xu, 2010) SMAD protein import into nucleus inferred from mutant phenotype (Chen and Xu, 2010)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function ( 0 terms)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
nuclear pore inferred from sequence or structural similarity with Saccharomyces NIC96 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG11092 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 58721 DroID - A comprehensive database of gene and protein interactions. • FBgn0027537 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32350
Orthologs
Genome-wide drosophilid orthologs	Dana\GF19214 Dere\GG17817 Dgri\GH17674 Dmoj\GI21492 Dper\GL14821 Dpse\GA10753 Dsec\GM17645 Dvir\GJ19033 Dwil\GK24989 Dyak\GE17112
Curated drosophilid orthologs	Dpse\GA10753   Dsim\CG11092 (Swanson et al., 2001)
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • XP_001949759.1 Acyrthosiphon pisum (pea aphid) 25641 Batrachochytrium dendrobatidis (chytrid fungus) 114148 Branchiostoma floridae (lancelet) XP_001894902.1 Brugia malayi (roundworm nematode) BGIBMGA003126-PA Bombyx mori (silk worm) CAL0004316 Candida albicans (a form of yeast) CN12336 Caenorhabditis brenneri (small nematode) CN16861 Caenorhabditis brenneri (small nematode) CBP05244 Caenorhabditis briggsae (nematode) CE26832 Caenorhabditis elegans (worm) JA08152 Caenorhabditis japonica (nematode) cn03290 Cryptococcus neoformans (yeast-like fungus) 180714 Chlamidomonas reinhardtii (green alga) RP48839 Caenorhabditis remanei (nematode) 177509 Capitella spl (polychaete worm) DDB0235249 Dictyostelium discoideum (amoeba) 91231 Hypsipyla robusta (cedar shoot borer) KLLA0E14191g Kluyveromyces lactis (yeast) 179365 Lottia gigantea (owl limpet) 242660 Nematostella vectensis (starlet anemone) XP_001607183.1 Nasonia vitripennis (wasp) LOC_Os03g22690.1 Oryza sativa (asian rice) PP26904 Pristionchus pacificus (nematode) 159641 Physcomitrella patens (moss) 823177 Populus trichocarpa (black cottonwood) 4744239 Sorghum bicolor (sorghum) YFR002W Saccharomyces cerevisiae (budding yeast) Smp_103100 Schistosoma mansoni (trematode parasite) SPCC1620.11 Schizosaccharomyces pombe (fission yeast) 49781 Trichoplax adhaerens (metazoa) XP_972877.1 Tribolium castaneum (red flour beetle) Tc00.1047053510181.50 Trypanosoma cruzi (parasitic trypanosome) 3814.m00853 Tetrahymena thermophila (ciliate protozoa) YALI0C22066g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB11972 NV10257 LH12118 ISCW023557 FBgn0243447 FBgn0234593 FBgn0226948 FBgn0224750 FBgn0211637 FBgn0206178 FBgn0191866 FBgn0180673 FBgn0172553 JGI_V11_187494 FBgn0248855 FBgn0080214 FBgn0070809 FBgn0152425 FBgn0149988 FBgn0149850 FBgn0147214 FBgn0144222 FBgn0038274 FBgn0126457 FBgn0125144 FBgn0113185 FBgn0110038 FBgn0100137 FBgn0096225 CPIJ004743 CPIJ013421 CPIJ019099 CPIJ005792 BGIBMGA003126 ACYPI006583 GB19407 AGAP003459 AAEL011682 PHUM584680 GLEAN_13667
Stocks & Reagents
Stocks Listed in FlyBase ( 8 )
Bloomington	32628 w* P{EP}CG11092G9996 33908 y1 sc* v1; P{TRiP.HMS00850}attP2 34090 y1 sc* v1; P{TRiP.HMS00898}attP2 31196 y1 v1; P{TRiP.JF01712}attP2/TM3, Sb1
Harvard	- PBac{RB}CG11092e03640
VDRC	v100315 P{KK105863}VIE-260B v16188 w1118; P{GD7196}v16188 v16189 w1118; P{GD7196}v16189/TM3
Genomic Clones ( 1 )
	BACR11H20 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 108 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD21129
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LD06506 LD11136 LD14633 LD21128 LD21808 LD22369 LD22501 LD26705 LD27367 LD27538 LD28420 LD30464 LD30616 LD32058 LD34362 LD35075 LD36656 LD38249 LD38618 LD38633 LD41151 LD43330 LD44088 LD44319 LD46961 LP09445 LP17443 RE02244 RE05977 RE07427 RE09062 RE15019 RE16967 RE22231 RE31254 RE36570 RE37291 RE37609 RE38379 RE40801 RE44171 RE47038 RE48841 RE49984 RE50741 RE51515 RE59779 RE67693 RE71715 RE72167 RE74269 SD02695 SD17945 SD18664 SD18962 SD25247 SD26747 SD28016
Other clones	10195 16478 36452 47542 55950 57347 57385 65015 82028 83179 106920 153487 153573 190837 214375.14 475363 CK01.6A.D8 CK01.40A.H6 CK01.54B.G11 CK01.54D.E8 CK01.124B.B12 Dmel_neb_013629_0934_3030 EK009248 EK044452 EK044528 EK094440 EK127945 EK147057 EK157108 EK175254 EK177750 EK215334 EK216846 EK244211 EK256911 EK293330 EN00753 EP07349 RP001002781 RP001005105 RP001008804 RP001011653 RP001013592 RP001023102 RP001023302 RP001033341 RP001043219 RP001043236 RP001054290
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0027537 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32350
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments	FlyBase Curator comment: Correspondence with author Lan Xu revealed that 'nup93' = CG11092. (Chen and Xu, 2010)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_132701 RefSeq (Proteins) • NP_572929 DDBJ / EMBL / GenBank • AA735336 AAD34747 AAF48327 AF132159 AI455097 CZ481394 Entrez Gene - A searchable database of RefSeq genes. • 32350 UniProtKB/TrEMBL • Q9XZ06
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Nucleoporin interacting component Nup93/Nic96 (IPR007231)
Linkouts
	BioGRID - A database of protein and genetic interactions • 58721 DroID - A comprehensive database of gene and protein interactions. • FBgn0027537 DRSC - Results from RNAi screens. • FBgn0027537 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0027537 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11092-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0027537 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32350 InParanoid A subset of ortholog calls from InParanoid. • XP_001949759.1 Acyrthosiphon pisum (pea aphid) 25641 Batrachochytrium dendrobatidis (chytrid fungus) 114148 Branchiostoma floridae (lancelet) XP_001894902.1 Brugia malayi (roundworm nematode) BGIBMGA003126-PA Bombyx mori (silk worm) CAL0004316 Candida albicans (a form of yeast) CN12336 Caenorhabditis brenneri (small nematode) CN16861 Caenorhabditis brenneri (small nematode) CBP05244 Caenorhabditis briggsae (nematode) CE26832 Caenorhabditis elegans (worm) JA08152 Caenorhabditis japonica (nematode) cn03290 Cryptococcus neoformans (yeast-like fungus) 180714 Chlamidomonas reinhardtii (green alga) RP48839 Caenorhabditis remanei (nematode) 177509 Capitella spl (polychaete worm) DDB0235249 Dictyostelium discoideum (amoeba) 91231 Hypsipyla robusta (cedar shoot borer) KLLA0E14191g Kluyveromyces lactis (yeast) 179365 Lottia gigantea (owl limpet) 242660 Nematostella vectensis (starlet anemone) XP_001607183.1 Nasonia vitripennis (wasp) LOC_Os03g22690.1 Oryza sativa (asian rice) PP26904 Pristionchus pacificus (nematode) 159641 Physcomitrella patens (moss) 823177 Populus trichocarpa (black cottonwood) 4744239 Sorghum bicolor (sorghum) YFR002W Saccharomyces cerevisiae (budding yeast) Smp_103100 Schistosoma mansoni (trematode parasite) SPCC1620.11 Schizosaccharomyces pombe (fission yeast) 49781 Trichoplax adhaerens (metazoa) XP_972877.1 Tribolium castaneum (red flour beetle) Tc00.1047053510181.50 Trypanosoma cruzi (parasitic trypanosome) 3814.m00853 Tetrahymena thermophila (ciliate protozoa) YALI0C22066g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32350 modMine - Data generated by the modENCODE project. • FBgn0027537 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB11972 NV10257 LH12118 ISCW023557 FBgn0243447 FBgn0234593 FBgn0226948 FBgn0224750 FBgn0211637 FBgn0206178 FBgn0191866 FBgn0180673 FBgn0172553 JGI_V11_187494 FBgn0248855 FBgn0080214 FBgn0070809 FBgn0152425 FBgn0149988 FBgn0149850 FBgn0147214 FBgn0144222 FBgn0038274 FBgn0126457 FBgn0125144 FBgn0113185 FBgn0110038 FBgn0100137 FBgn0096225 CPIJ004743 CPIJ013421 CPIJ019099 CPIJ005792 BGIBMGA003126 ACYPI006583 GB19407 AGAP003459 AAEL011682 PHUM584680 GLEAN_13667
Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	BcDNA:LD21129 (Giot et al., 2003, ) CG11092 (Finan et al., 2011, Keleman et al., 2009.8.5, Haussmann et al., 2008, Ni et al., 2008, Ni et al., 2010.12.1) nup93 (Asensio et al., 2010, Chen and Xu, 2010)
Name Synonym
Secondary FlyBase IDs
References ( 20 )
Research paper	Finan et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(14): 5566--5571 From the Cover: Proteomics approach to study the functions of Drosophila myosin VI through identification of multiple cargo-binding proteins. [FBrf0213355] Asensio et al., 2010, J. Cell Biol. 191(6): 1173--1187 RNAi screen identifies a role for adaptor protein AP-3 in sorting to the regulated secretory pathway. [FBrf0212515] Chen and Xu, 2010, Mol. Cell. Biol. 30(16): 4022--4034 Specific nucleoporin requirement for smad nuclear translocation. [FBrf0211334] Haussmann et al., 2008, Genome Biol. 9(4): R73 Erect wing regulates synaptic growth in Drosophila by integration of multiple signaling pathways. [FBrf0209726] Ni et al., 2008, Nature Methods 5(1): 49--51 Vector and parameters for targeted transgenic RNA interference in Drosophila melanogaster. [FBrf0200406]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452] Swanson et al., 2001, Proc. Natl. Acad. Sci. USA 98: Gene characteristics and dN/dS ratios of Drosophila simulans. [FBrf0137427]
Personal communication to FlyBase	Bellen, 2010.10.18, BDGP_2010_1022.GenExel.xml BDGP_2010_1022.GenExel.xml [FBrf0212107] Ni et al., 2010.12.1, A genome-scale shRNA resource for transgenic RNAi in Drosophila. A genome-scale shRNA resource for transgenic RNAi in Drosophila. [FBrf0212437] Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327]
FlyBase analysis	FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	Gene Disruption Project members and Exelixis, 2005, Genomic mapping of Exelixis insertion collection. Genomic mapping of Exelixis insertion collection. [FBrf0184340] Gene Disruption Project members, 2001-, [title not yet available] [title not yet available] [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]
Automatic genome annotation	FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126705]
Curated genome annotation	Zhong, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126703]