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Gene Dmel\Tps1

General Information
Symbol	Dmel\Tps1	Species	D. melanogaster
Name	Trehalose-6-phosphate synthase 1	Annotation symbol	CG4104
Feature type	protein_coding_gene	FlyBase ID	FBgn0027560
Gene Model Status	Current	Stock availability	3 publicly available
Also Known As	jf5, BcDNA:GH08860, l(2)k08903
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	24E4-24E5	Sequence location	2L:4,388,327..4,392,778 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Trehalose-6-phosphate synthase 1 is referred to in FlyBase by the symbol Dmel\Tps1 (CG4104, FBgn0027560). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: trehalose biosynthetic process. 15 alleles are reported. The phenotypes of these alleles are annotated with: eye; ommatidium. It has one annotated transcript and one annotated polypeptide. Protein features are: Glycosyl transferase, family 20; HAD-like domain; HAD-superfamily hydrolase, subfamily IIB; Trehalose-phosphatase. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of very low expression. Peak expression observed during early larval stages, during late pupal stages, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult hindgut, adult Malpighian tubules, adult heart, larval/adult fat body, adult spermathecae, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult crop. Comments on Affy2 ProbeSet: ProbeSet 1639415_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Tps1. Gene sequence location is 2L:4388327..4392778.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 24E4-24E5   Limits computationally determined from genome sequence between P{EP}Traf1EP578 and P{lacW}Tps1k08903&P{EP}morgueEP1184
Experimentally Determined Cytological Location
Cytogenetic map Notes References 24F1-24F2   (determined by in situ hybridisation)   (Spradling et al., 1999) 24F1-24F2     (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Tps1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.44
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Tps1-RA FBtr0077431  NM_134983   2920   809
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Tps1-PA   FBpp0077121   91.1   809   6.85     NP_608827   AAF51020
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Glycosyl transferase, family 20 (IPR001830) Trehalose-phosphatase (IPR003337) HAD-superfamily hydrolase, subfamily IIB (IPR006379) HAD-like domain (IPR023214)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA567437   AA697904   AA699225   AE014134 AAF51020   AF145653 AAD38628   AI061998   AI063085   AI063900   AI064592   AI106723   AI106945   AI107199   AI107460   AI107976   AI108298   AI108880   AI109201   AI109568   AI109620   AI109797   AI110051   AI113480   AI133905   AI133947   AI135198   AI135841   AI237986   AI238017   AI238285   AI292841   AI293266   AI293452   AI294439   AI295413   AI297236   AI386694   AI386699   AI386854   AI386870   AI387151   AI387759   AI387938   AI388007   AI388038   AI388208   AI388656   AI388657   AI389065   AI389268   AI389699   AI402150   AI402738   AI402898   AI403027   AI403775   AI404282   AI404297   AI404486   AI404573   AI404619   AI405472   AI405673   AI406228   AI513533   AI517271   AI517633   AQ034018   BI165477   BI165535   BI169889   BI172688   BI212326   BI214940   BI229152   BI229656   BI361644   BI364725   BI369098   BI566385   BI566449   BI567136   BI567164   BI568312   BI570345   BI571284   BI573198   BI573199   BI574565   BI575419   BI576227   BI576445   BI576987   BI577028   BI578257   BI578279   BI580949   BI580950   BI582633   BI582754   BI583604   BI584771   BI584803   BI585425   BI585614   BI587676   BI587772   BI588616   BI589088   BI589926   BI589948   BI590208   BI590494   BI590927   BI590982   BI591559   BI591596   BI591751   BI591807   BI604425   BI605517   BI605624   BI605700   BI606271   BI606451   BI611555   BI612356   BI613030   BI613577   BI614908   BI615649   BI616180   BI616280   BI616913   BI617516   BI617964   BI618034   BI618044   BI619148   BI620218   BI620955   BI623450   BI624351   BI624471   BI625383   BI625544   BI625599   BI625992   BI627233   BI627545   BI629006   BI630150   BI630662   BI630667   BI631953   BT021328 AAX33476   CK657013   CK658898   CO265952   CO293041   CO323271   EC069310   EC086645   EC090505   EC205029   EC223677   EC227617   EC228958   EC238234   EC244808   EC257798   EC258617   EL869748   EL874077   EL874078   EL874205   EL881908   ES695464   EV584698   EV598334   GH748842   GH752317   GH752565   GH755620   GH757157   GH758514   GH758702   GH759453   GH759896   GH760383   GH760998   GH761113   GH770525   GH770806   GH771354   GH774313   GH778916   GH782768   GH782841   GH797109   GH798624   GH799025   GH801685   GH803755   GH804155   GH806873   GH807521   GH812733   GH813688   GH817977   GH818649   GH819783   GH821787   GH822059   GH823274   GH823737   GH824759   GH825648   GH825663   GH826352   GH827889   GH828580   GH829893   GH830277   GH833516   GH833777   GH839169   GH842397   GH843040   GH848924   GH850811   GH851080   GH852185   GH859942   GH862148   GH863306   GH869955   GH871258   GH871281   GH871690   GH872362   GH874009   GH874414   GH874905   GH876374   GH876713   GH876974   GH877108   GH884840   GH885606   GH886788   GH887672   GH888369   GH888668   GH892981   GH893073   GH894455   GH895051   GH895190   GH895610   GH897995   GH900604   GH908071   GH908222   GH909329   GH909666   GH910123   GH911911   GH912483   GH916031   GH917975   GH921322   GH921940   GH923883   GH927180   GH927277   GH929689   GH929749   GH933089   GH937029   GH938887   GH939657   GH940245   GH940712
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9Y119
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 11 -- 12   yolk nucleus   (Fisher et al., 2012) embryonic stage 13 -- 16   yolk nucleus   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010) day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
lipid particle inferred from direct assay (Beller et al., 2006)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult hindgut, adult Malpighian tubules, adult heart, larval/adult fat body, adult spermathecae, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult crop. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    2.875 Larval Midgut    14.6 Larval Hindgut    49.7 Larval Malpighian Tubules    5 Larval Fat Body    1942.1 Larval Salivary Gland    43.3 Larval Trachea    24.375 Larval Carcass    14.875 Adult Head    1859.5 Adult Eye    639.625 Adult Brain    66.1 Adult Thoracic-Abdominal Ganglion    95.7 Adult Crop    125.4 Adult Midgut    16.8 Adult Hindgut    740.1 Adult Malpighian Tubules    6798.4 Adult Fat Body    5409.4 Adult Salivary Gland    28 Adult Heart    4343.25 Adult VirginFemale Spermatheca    5817.4 Adult InseminatedFemale Spermatheca    5839.5 Adult Ovary    3 Adult Testis    40.3 Adult Male Accessory Gland    11.9 Adult Carcass    4995.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    2.875 Larval Midgut    14.6 Larval Hindgut    49.7 Larval Malpighian Tubules    5 Larval Fat Body  (1942.1) Larval Salivary Gland    43.3 Larval Trachea    24.375 Larval Carcass    14.875 Adult Head  (1859.5) Adult Eye  (639.625) Adult Brain    66.1 Adult Thoracic-Abdominal Ganglion    95.7 Adult Crop    125.4 Adult Midgut    16.8 Adult Hindgut  (740.1) Adult Malpighian Tubules  (6798.4) Adult Fat Body  (5409.4) Adult Salivary Gland    28 Adult Heart  (4343.25) Adult VirginFemale Spermatheca  (5817.4) Adult InseminatedFemale Spermatheca  (5839.5) Adult Ovary    3 Adult Testis    40.3 Adult Male Accessory Gland    11.9 Adult Carcass  (4995.5) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    2.875 Larval Midgut    14.6 Larval Hindgut    49.7 Larval Malpighian Tubules    5 Larval Fat Body  (1942.1) Larval Salivary Gland    43.3 Larval Trachea    24.375 Larval Carcass    14.875 Adult Head  (1859.5) Adult Eye    639.625 Adult Brain    66.1 Adult Thoracic-Abdominal Ganglion    95.7 Adult Crop    125.4 Adult Midgut    16.8 Adult Hindgut    740.1 Adult Malpighian Tubules  (6798.4) Adult Fat Body  (5409.4) Adult Salivary Gland    28 Adult Heart  (4343.25) Adult VirginFemale Spermatheca  (5817.4) Adult InseminatedFemale Spermatheca  (5839.5) Adult Ovary    3 Adult Testis    40.3 Adult Male Accessory Gland    11.9 Adult Carcass  (4995.5) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    2.875 Larval Midgut    14.6 Larval Hindgut    49.7 Larval Malpighian Tubules    5 Larval Fat Body    1942.1 Larval Salivary Gland    43.3 Larval Trachea    24.375 Larval Carcass    14.875 Adult Head    1859.5 Adult Eye    639.625 Adult Brain    66.1 Adult Thoracic-Abdominal Ganglion    95.7 Adult Crop    125.4 Adult Midgut    16.8 Adult Hindgut    740.1 Adult Malpighian Tubules    6798.4 Adult Fat Body    5409.4 Adult Salivary Gland    28 Adult Heart    4343.25 Adult VirginFemale Spermatheca    5817.4 Adult InseminatedFemale Spermatheca    5839.5 Adult Ovary    3 Adult Testis    40.3 Adult Male Accessory Gland    11.9 Adult Carcass    4995.5 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    2.875 Larval Midgut    14.6 Larval Hindgut    49.7 Larval Malpighian Tubules    5 Larval Fat Body    1942.1 Larval Salivary Gland    43.3 Larval Trachea    24.375 Larval Carcass    14.875 Adult Head    1859.5 Adult Eye    639.625 Adult Brain    66.1 Adult Thoracic-Abdominal Ganglion    95.7 Adult Crop    125.4 Adult Midgut    16.8 Adult Hindgut    740.1 Adult Malpighian Tubules    6798.4 Adult Fat Body    5409.4 Adult Salivary Gland    28 Adult Heart    4343.25 Adult VirginFemale Spermatheca    5817.4 Adult InseminatedFemale Spermatheca    5839.5 Adult Ovary    3 Adult Testis    40.3 Adult Male Accessory Gland    11.9 Adult Carcass    4995.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    2.875 Larval Midgut    14.6 Larval Hindgut    49.7 Larval Malpighian Tubules    5 Larval Fat Body  (1942.1) Larval Salivary Gland    43.3 Larval Trachea    24.375 Larval Carcass    14.875 Adult Head  (1859.5) Adult Eye  639.625 Adult Brain    66.1 Adult Thoracic-Abdominal Ganglion    95.7 Adult Crop    125.4 Adult Midgut    16.8 Adult Hindgut  740.1 Adult Malpighian Tubules  (6798.4) Adult Fat Body  (5409.4) Adult Salivary Gland    28 Adult Heart  (4343.25) Adult VirginFemale Spermatheca  (5817.4) Adult InseminatedFemale Spermatheca  (5839.5) Adult Ovary    3 Adult Testis    40.3 Adult Male Accessory Gland    11.9 Adult Carcass  (4995.5) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    2.875 Larval Midgut    14.6 Larval Hindgut    49.7 Larval Malpighian Tubules    5 Larval Fat Body  (1942.1) Larval Salivary Gland    43.3 Larval Trachea    24.375 Larval Carcass    14.875 Adult Head  (1859.5) Adult Eye    639.625 Adult Brain    66.1 Adult Thoracic-Abdominal Ganglion    95.7 Adult Crop    125.4 Adult Midgut    16.8 Adult Hindgut    740.1 Adult Malpighian Tubules  (6798.4) Adult Fat Body  (5409.4) Adult Salivary Gland    28 Adult Heart  (4343.25) Adult VirginFemale Spermatheca  (5817.4) Adult InseminatedFemale Spermatheca  (5839.5) Adult Ovary    3 Adult Testis    40.3 Adult Male Accessory Gland    11.9 Adult Carcass  (4995.5) Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    2.875 Larval Midgut    14.6 Larval Hindgut    49.7 Larval Malpighian Tubules    5 Larval Fat Body    1942.1 Larval Salivary Gland    43.3 Larval Trachea    24.375 Larval Carcass    14.875 Adult Head    1859.5 Adult Eye    639.625 Adult Brain    66.1 Adult Thoracic-Abdominal Ganglion    95.7 Adult Crop    125.4 Adult Midgut    16.8 Adult Hindgut    740.1 Adult Malpighian Tubules    6798.4 Adult Fat Body    5409.4 Adult Salivary Gland    28 Adult Heart    4343.25 Adult VirginFemale Spermatheca    5817.4 Adult InseminatedFemale Spermatheca    5839.5 Adult Ovary    3 Adult Testis    40.3 Adult Male Accessory Gland    11.9 Adult Carcass    4995.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    1859.5   NA  Eye    639.625   NA  Brain    66.1   2.875  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    95.7   NA  Crop    125.4   no informative data  Midgut    no informative data   49.7  Hindgut    740.1   5  Malpighian Tubules    6798.4   1942.1  Fat Body    5409.4   43.3  Salivary Gland    28   NA  Heart    4343.25   no informative data  Trachea    NA   NA  VirginFemale Spermatheca    5817.4   NA  InseminatedFemale Spermatheca    5839.5   NA  Ovary    3   NA  Testis    40.3   NA  Male Accessory Gland    no informative data   no informative data  Carcass    4995.5 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    1 head, virgin 1-day female    292 head, virgin 4-day female    405 head, virgin 20-day female    545 head, mated 1-day female    267 head, mated 4-day female    369 head, mated 20-day female    332 head, mated 1-day male    297 head, mated 4-day male    304 head, mated 20-day male    617 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    231 digestive system, 4-day adult    151 digestive system, 20-day adult    199 fat body, larvae L3 wandering    206 fat body, white prepupae    41 fat body, pupae P8    46 carcass, larvae L3 wandering    10 carcass, 1-day adult    409 carcass, 4-day adult    449 carcass, 20-day adult    607 ovary, virgin 4-day female    3 ovary, mated 4-day female    1 testis, mated 4-day male    60 accessory gland, mated 4-day male    36 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    1 head, virgin 1-day female  (292) head, virgin 4-day female  (405) head, virgin 20-day female  (545) head, mated 1-day female  (267) head, mated 4-day female  (369) head, mated 20-day female  (332) head, mated 1-day male  (297) head, mated 4-day male  (304) head, mated 20-day male  (617) salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    2 digestive system, 1-day adult  (231) digestive system, 4-day adult  (151) digestive system, 20-day adult  (199) fat body, larvae L3 wandering  (206) fat body, white prepupae  (41) fat body, pupae P8  (46) carcass, larvae L3 wandering    10 carcass, 1-day adult  (409) carcass, 4-day adult  (449) carcass, 20-day adult  (607) ovary, virgin 4-day female    3 ovary, mated 4-day female    1 testis, mated 4-day male  (60) accessory gland, mated 4-day male  (36) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    1 head, virgin 1-day female  (292) head, virgin 4-day female  (405) head, virgin 20-day female  (545) head, mated 1-day female  (267) head, mated 4-day female  (369) head, mated 20-day female  (332) head, mated 1-day male  (297) head, mated 4-day male  (304) head, mated 20-day male  (617) salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    2 digestive system, 1-day adult  (231) digestive system, 4-day adult  (151) digestive system, 20-day adult  (199) fat body, larvae L3 wandering  (206) fat body, white prepupae    41 fat body, pupae P8    46 carcass, larvae L3 wandering    10 carcass, 1-day adult  (409) carcass, 4-day adult  (449) carcass, 20-day adult  (607) ovary, virgin 4-day female    3 ovary, mated 4-day female    1 testis, mated 4-day male    60 accessory gland, mated 4-day male    36 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    1 head, virgin 1-day female    292 head, virgin 4-day female    405 head, virgin 20-day female    545 head, mated 1-day female    267 head, mated 4-day female    369 head, mated 20-day female    332 head, mated 1-day male    297 head, mated 4-day male    304 head, mated 20-day male    617 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    231 digestive system, 4-day adult    151 digestive system, 20-day adult    199 fat body, larvae L3 wandering    206 fat body, white prepupae    41 fat body, pupae P8    46 carcass, larvae L3 wandering    10 carcass, 1-day adult    409 carcass, 4-day adult    449 carcass, 20-day adult    607 ovary, virgin 4-day female    3 ovary, mated 4-day female    1 testis, mated 4-day male    60 accessory gland, mated 4-day male    36 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    1 head, virgin 1-day female    292 head, virgin 4-day female    405 head, virgin 20-day female    545 head, mated 1-day female    267 head, mated 4-day female    369 head, mated 20-day female    332 head, mated 1-day male    297 head, mated 4-day male    304 head, mated 20-day male    617 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    231 digestive system, 4-day adult    151 digestive system, 20-day adult    199 fat body, larvae L3 wandering    206 fat body, white prepupae    41 fat body, pupae P8    46 carcass, larvae L3 wandering    10 carcass, 1-day adult    409 carcass, 4-day adult    449 carcass, 20-day adult    607 ovary, virgin 4-day female    3 ovary, mated 4-day female    1 testis, mated 4-day male    60 accessory gland, mated 4-day male    36 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    1 head, virgin 1-day female  (292) head, virgin 4-day female  (405) head, virgin 20-day female  (545) head, mated 1-day female  (267) head, mated 4-day female  (369) head, mated 20-day female  (332) head, mated 1-day male  (297) head, mated 4-day male  (304) head, mated 20-day male  (617) salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    2 digestive system, 1-day adult  (231) digestive system, 4-day adult  (151) digestive system, 20-day adult  (199) fat body, larvae L3 wandering  (206) fat body, white prepupae  (41) fat body, pupae P8  (46) carcass, larvae L3 wandering    10 carcass, 1-day adult  (409) carcass, 4-day adult  (449) carcass, 20-day adult  (607) ovary, virgin 4-day female    3 ovary, mated 4-day female    1 testis, mated 4-day male  (60) accessory gland, mated 4-day male  (36) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    1 head, virgin 1-day female  (292) head, virgin 4-day female  (405) head, virgin 20-day female  (545) head, mated 1-day female  (267) head, mated 4-day female  (369) head, mated 20-day female  (332) head, mated 1-day male  (297) head, mated 4-day male  (304) head, mated 20-day male  (617) salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    2 digestive system, 1-day adult  (231) digestive system, 4-day adult  (151) digestive system, 20-day adult  (199) fat body, larvae L3 wandering  (206) fat body, white prepupae    41 fat body, pupae P8    46 carcass, larvae L3 wandering    10 carcass, 1-day adult  (409) carcass, 4-day adult  (449) carcass, 20-day adult  (607) ovary, virgin 4-day female    3 ovary, mated 4-day female    1 testis, mated 4-day male    60 accessory gland, mated 4-day male    36 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    1 head, virgin 1-day female    292 head, virgin 4-day female    405 head, virgin 20-day female    545 head, mated 1-day female    267 head, mated 4-day female    369 head, mated 20-day female    332 head, mated 1-day male    297 head, mated 4-day male    304 head, mated 20-day male    617 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    231 digestive system, 4-day adult    151 digestive system, 20-day adult    199 fat body, larvae L3 wandering    206 fat body, white prepupae    41 fat body, pupae P8    46 carcass, larvae L3 wandering    10 carcass, 1-day adult    409 carcass, 4-day adult    449 carcass, 20-day adult    607 ovary, virgin 4-day female    3 ovary, mated 4-day female    1 testis, mated 4-day male    60 accessory gland, mated 4-day male    36 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of very low expression. Peak expression observed during early larval stages, during late pupal stages, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    5 embryo 04-06hr    17 embryo 06-08hr    76 embryo 08-10hr    67 embryo 10-12hr    44 embryo 12-14hr    28 embryo 14-16hr    46 embryo 16-18hr    43 embryo 18-20hr    79 embryo 20-22hr    96 embryo 22-24hr    94 larva L1    105 larva L2    116 larva L3 12hr old    162 larva L3 puffstage 1-2    79 larva L3 puffstage 3-6    55 larva L3 puffstage 7-9    22 white prepupae new    28 white prepupae 12hr    12 white prepupae 24hr    27 pupae 2d postWPP    42 pupae 3d postWPP    25 pupae 4d postWPP    235 adult male 01day    376 adult male 05day    320 adult male 30day    329 adult female 01day    208 adult female 05day    123 adult female 30day    146 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    5 embryo 04-06hr    17 embryo 06-08hr  (76) embryo 08-10hr  (67) embryo 10-12hr  (44) embryo 12-14hr  (28) embryo 14-16hr  (46) embryo 16-18hr  (43) embryo 18-20hr  (79) embryo 20-22hr  (96) embryo 22-24hr  (94) larva L1  (105) larva L2  (116) larva L3 12hr old  (162) larva L3 puffstage 1-2  (79) larva L3 puffstage 3-6  (55) larva L3 puffstage 7-9    22 white prepupae new  (28) white prepupae 12hr    12 white prepupae 24hr  (27) pupae 2d postWPP  (42) pupae 3d postWPP    25 pupae 4d postWPP  (235) adult male 01day  (376) adult male 05day  (320) adult male 30day  (329) adult female 01day  (208) adult female 05day  (123) adult female 30day  (146) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    5 embryo 04-06hr    17 embryo 06-08hr    76 embryo 08-10hr    67 embryo 10-12hr    44 embryo 12-14hr    28 embryo 14-16hr    46 embryo 16-18hr    43 embryo 18-20hr    79 embryo 20-22hr    96 embryo 22-24hr    94 larva L1  105 larva L2  (116) larva L3 12hr old  (162) larva L3 puffstage 1-2    79 larva L3 puffstage 3-6    55 larva L3 puffstage 7-9    22 white prepupae new    28 white prepupae 12hr    12 white prepupae 24hr    27 pupae 2d postWPP    42 pupae 3d postWPP    25 pupae 4d postWPP  (235) adult male 01day  (376) adult male 05day  (320) adult male 30day  (329) adult female 01day  (208) adult female 05day  (123) adult female 30day  (146) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    5 embryo 04-06hr    17 embryo 06-08hr    76 embryo 08-10hr    67 embryo 10-12hr    44 embryo 12-14hr    28 embryo 14-16hr    46 embryo 16-18hr    43 embryo 18-20hr    79 embryo 20-22hr    96 embryo 22-24hr    94 larva L1    105 larva L2    116 larva L3 12hr old    162 larva L3 puffstage 1-2    79 larva L3 puffstage 3-6    55 larva L3 puffstage 7-9    22 white prepupae new    28 white prepupae 12hr    12 white prepupae 24hr    27 pupae 2d postWPP    42 pupae 3d postWPP    25 pupae 4d postWPP    235 adult male 01day    376 adult male 05day    320 adult male 30day    329 adult female 01day    208 adult female 05day    123 adult female 30day    146 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    5 embryo 04-06hr    17 embryo 06-08hr    76 embryo 08-10hr    67 embryo 10-12hr    44 embryo 12-14hr    28 embryo 14-16hr    46 embryo 16-18hr    43 embryo 18-20hr    79 embryo 20-22hr    96 embryo 22-24hr    94 larva L1    105 larva L2    116 larva L3 12hr old    162 larva L3 puffstage 1-2    79 larva L3 puffstage 3-6    55 larva L3 puffstage 7-9    22 white prepupae new    28 white prepupae 12hr    12 white prepupae 24hr    27 pupae 2d postWPP    42 pupae 3d postWPP    25 pupae 4d postWPP    235 adult male 01day    376 adult male 05day    320 adult male 30day    329 adult female 01day    208 adult female 05day    123 adult female 30day    146 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    5 embryo 04-06hr    17 embryo 06-08hr  (76) embryo 08-10hr  (67) embryo 10-12hr  (44) embryo 12-14hr  28 embryo 14-16hr  (46) embryo 16-18hr  (43) embryo 18-20hr  (79) embryo 20-22hr  (96) embryo 22-24hr  (94) larva L1  (105) larva L2  (116) larva L3 12hr old  (162) larva L3 puffstage 1-2  (79) larva L3 puffstage 3-6  (55) larva L3 puffstage 7-9    22 white prepupae new  28 white prepupae 12hr    12 white prepupae 24hr  27 pupae 2d postWPP  (42) pupae 3d postWPP    25 pupae 4d postWPP  (235) adult male 01day  (376) adult male 05day  (320) adult male 30day  (329) adult female 01day  (208) adult female 05day  (123) adult female 30day  (146) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    5 embryo 04-06hr    17 embryo 06-08hr    76 embryo 08-10hr    67 embryo 10-12hr    44 embryo 12-14hr    28 embryo 14-16hr    46 embryo 16-18hr    43 embryo 18-20hr    79 embryo 20-22hr    96 embryo 22-24hr    94 larva L1  105 larva L2  116 larva L3 12hr old  (162) larva L3 puffstage 1-2    79 larva L3 puffstage 3-6    55 larva L3 puffstage 7-9    22 white prepupae new    28 white prepupae 12hr    12 white prepupae 24hr    27 pupae 2d postWPP    42 pupae 3d postWPP    25 pupae 4d postWPP  (235) adult male 01day  (376) adult male 05day  (320) adult male 30day  (329) adult female 01day  (208) adult female 05day  123 adult female 30day  (146) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    5 embryo 04-06hr    17 embryo 06-08hr    76 embryo 08-10hr    67 embryo 10-12hr    44 embryo 12-14hr    28 embryo 14-16hr    46 embryo 16-18hr    43 embryo 18-20hr    79 embryo 20-22hr    96 embryo 22-24hr    94 larva L1    105 larva L2    116 larva L3 12hr old    162 larva L3 puffstage 1-2    79 larva L3 puffstage 3-6    55 larva L3 puffstage 7-9    22 white prepupae new    28 white prepupae 12hr    12 white prepupae 24hr    27 pupae 2d postWPP    42 pupae 3d postWPP    25 pupae 4d postWPP    235 adult male 01day    376 adult male 05day    320 adult male 30day    329 adult female 01day    208 adult female 05day    123 adult female 30day    146 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    3 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    3 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    1 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    1 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    3 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    3 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    1 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    1 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    3 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    3 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    1 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    1 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    3 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    3 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    1 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    1 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    3 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    3 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    1 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    1 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    3 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    3 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    1 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    1 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    3 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    3 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    1 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    1 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    3 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    3 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    1 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    1 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    76 cold shock, 4-day adult    53 heat shock, 4-day adult    99 Cadmium 50 mM 6 hrs, larvae L3    49 Cadmium 50 mM 12 hrs, larvae L3    22 Cadmium 50 mM 48 hrs, 4-day adult    78 Cadmium 100 mM 48 hrs, 4-day adult    119 Copper 0.5 mM 12 hrs, larvae L3    23 Copper 15 mM 48 hrs, 4-day adult    74 Zinc 5 mM 12 hrs, larvae L3    17 Zinc 4.5 mM 48 hrs, 4-day adult    141 Ethanol 2.5% 3 hrs, larvae L3    197 Ethanol 5% 3 hrs, larvae L3    60 Ethanol 10% 3 hrs, larvae L3    47 Caffeine 1.5 mg/ml 4 hrs, larvae L3    60 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    307 Caffeine 25 mg/ml 48 hrs, 4-day adult    68 Paraquat 5 mM 48 hrs, 4-day adult    256 Paraquat 10 mM 48 hrs, 4-day adult    141 Rotenone 2 μg 12 hrs, larvae L3    33 Rotenone 8 μg 12 hrs, larvae L3    45 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (76) cold shock, 4-day adult  (53) heat shock, 4-day adult  (99) Cadmium 50 mM 6 hrs, larvae L3  (49) Cadmium 50 mM 12 hrs, larvae L3    22 Cadmium 50 mM 48 hrs, 4-day adult  (78) Cadmium 100 mM 48 hrs, 4-day adult  (119) Copper 0.5 mM 12 hrs, larvae L3    23 Copper 15 mM 48 hrs, 4-day adult  (74) Zinc 5 mM 12 hrs, larvae L3    17 Zinc 4.5 mM 48 hrs, 4-day adult  (141) Ethanol 2.5% 3 hrs, larvae L3  (197) Ethanol 5% 3 hrs, larvae L3  (60) Ethanol 10% 3 hrs, larvae L3  (47) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (60) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (307) Caffeine 25 mg/ml 48 hrs, 4-day adult  (68) Paraquat 5 mM 48 hrs, 4-day adult  (256) Paraquat 10 mM 48 hrs, 4-day adult  (141) Rotenone 2 μg 12 hrs, larvae L3  (33) Rotenone 8 μg 12 hrs, larvae L3  (45) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    76 cold shock, 4-day adult    53 heat shock, 4-day adult    99 Cadmium 50 mM 6 hrs, larvae L3    49 Cadmium 50 mM 12 hrs, larvae L3    22 Cadmium 50 mM 48 hrs, 4-day adult    78 Cadmium 100 mM 48 hrs, 4-day adult  (119) Copper 0.5 mM 12 hrs, larvae L3    23 Copper 15 mM 48 hrs, 4-day adult    74 Zinc 5 mM 12 hrs, larvae L3    17 Zinc 4.5 mM 48 hrs, 4-day adult  (141) Ethanol 2.5% 3 hrs, larvae L3  (197) Ethanol 5% 3 hrs, larvae L3    60 Ethanol 10% 3 hrs, larvae L3    47 Caffeine 1.5 mg/ml 4 hrs, larvae L3    60 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (307) Caffeine 25 mg/ml 48 hrs, 4-day adult    68 Paraquat 5 mM 48 hrs, 4-day adult  (256) Paraquat 10 mM 48 hrs, 4-day adult  (141) Rotenone 2 μg 12 hrs, larvae L3    33 Rotenone 8 μg 12 hrs, larvae L3    45 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    76 cold shock, 4-day adult    53 heat shock, 4-day adult    99 Cadmium 50 mM 6 hrs, larvae L3    49 Cadmium 50 mM 12 hrs, larvae L3    22 Cadmium 50 mM 48 hrs, 4-day adult    78 Cadmium 100 mM 48 hrs, 4-day adult    119 Copper 0.5 mM 12 hrs, larvae L3    23 Copper 15 mM 48 hrs, 4-day adult    74 Zinc 5 mM 12 hrs, larvae L3    17 Zinc 4.5 mM 48 hrs, 4-day adult    141 Ethanol 2.5% 3 hrs, larvae L3    197 Ethanol 5% 3 hrs, larvae L3    60 Ethanol 10% 3 hrs, larvae L3    47 Caffeine 1.5 mg/ml 4 hrs, larvae L3    60 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    307 Caffeine 25 mg/ml 48 hrs, 4-day adult    68 Paraquat 5 mM 48 hrs, 4-day adult    256 Paraquat 10 mM 48 hrs, 4-day adult    141 Rotenone 2 μg 12 hrs, larvae L3    33 Rotenone 8 μg 12 hrs, larvae L3    45 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    76 cold shock, 4-day adult    53 heat shock, 4-day adult    99 Cadmium 50 mM 6 hrs, larvae L3    49 Cadmium 50 mM 12 hrs, larvae L3    22 Cadmium 50 mM 48 hrs, 4-day adult    78 Cadmium 100 mM 48 hrs, 4-day adult    119 Copper 0.5 mM 12 hrs, larvae L3    23 Copper 15 mM 48 hrs, 4-day adult    74 Zinc 5 mM 12 hrs, larvae L3    17 Zinc 4.5 mM 48 hrs, 4-day adult    141 Ethanol 2.5% 3 hrs, larvae L3    197 Ethanol 5% 3 hrs, larvae L3    60 Ethanol 10% 3 hrs, larvae L3    47 Caffeine 1.5 mg/ml 4 hrs, larvae L3    60 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    307 Caffeine 25 mg/ml 48 hrs, 4-day adult    68 Paraquat 5 mM 48 hrs, 4-day adult    256 Paraquat 10 mM 48 hrs, 4-day adult    141 Rotenone 2 μg 12 hrs, larvae L3    33 Rotenone 8 μg 12 hrs, larvae L3    45 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (76) cold shock, 4-day adult  (53) heat shock, 4-day adult  (99) Cadmium 50 mM 6 hrs, larvae L3  (49) Cadmium 50 mM 12 hrs, larvae L3    22 Cadmium 50 mM 48 hrs, 4-day adult  (78) Cadmium 100 mM 48 hrs, 4-day adult  (119) Copper 0.5 mM 12 hrs, larvae L3    23 Copper 15 mM 48 hrs, 4-day adult  (74) Zinc 5 mM 12 hrs, larvae L3    17 Zinc 4.5 mM 48 hrs, 4-day adult  (141) Ethanol 2.5% 3 hrs, larvae L3  (197) Ethanol 5% 3 hrs, larvae L3  (60) Ethanol 10% 3 hrs, larvae L3  (47) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (60) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (307) Caffeine 25 mg/ml 48 hrs, 4-day adult  (68) Paraquat 5 mM 48 hrs, 4-day adult  (256) Paraquat 10 mM 48 hrs, 4-day adult  (141) Rotenone 2 μg 12 hrs, larvae L3  (33) Rotenone 8 μg 12 hrs, larvae L3  (45) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    76 cold shock, 4-day adult    53 heat shock, 4-day adult    99 Cadmium 50 mM 6 hrs, larvae L3    49 Cadmium 50 mM 12 hrs, larvae L3    22 Cadmium 50 mM 48 hrs, 4-day adult    78 Cadmium 100 mM 48 hrs, 4-day adult  119 Copper 0.5 mM 12 hrs, larvae L3    23 Copper 15 mM 48 hrs, 4-day adult    74 Zinc 5 mM 12 hrs, larvae L3    17 Zinc 4.5 mM 48 hrs, 4-day adult  141 Ethanol 2.5% 3 hrs, larvae L3  (197) Ethanol 5% 3 hrs, larvae L3    60 Ethanol 10% 3 hrs, larvae L3    47 Caffeine 1.5 mg/ml 4 hrs, larvae L3    60 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (307) Caffeine 25 mg/ml 48 hrs, 4-day adult    68 Paraquat 5 mM 48 hrs, 4-day adult  (256) Paraquat 10 mM 48 hrs, 4-day adult  141 Rotenone 2 μg 12 hrs, larvae L3    33 Rotenone 8 μg 12 hrs, larvae L3    45 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    76 cold shock, 4-day adult    53 heat shock, 4-day adult    99 Cadmium 50 mM 6 hrs, larvae L3    49 Cadmium 50 mM 12 hrs, larvae L3    22 Cadmium 50 mM 48 hrs, 4-day adult    78 Cadmium 100 mM 48 hrs, 4-day adult    119 Copper 0.5 mM 12 hrs, larvae L3    23 Copper 15 mM 48 hrs, 4-day adult    74 Zinc 5 mM 12 hrs, larvae L3    17 Zinc 4.5 mM 48 hrs, 4-day adult    141 Ethanol 2.5% 3 hrs, larvae L3    197 Ethanol 5% 3 hrs, larvae L3    60 Ethanol 10% 3 hrs, larvae L3    47 Caffeine 1.5 mg/ml 4 hrs, larvae L3    60 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    307 Caffeine 25 mg/ml 48 hrs, 4-day adult    68 Paraquat 5 mM 48 hrs, 4-day adult    256 Paraquat 10 mM 48 hrs, 4-day adult    141 Rotenone 2 μg 12 hrs, larvae L3    33 Rotenone 8 μg 12 hrs, larvae L3    45 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_20 mE1_20_mRNA_expression_cluster_15
External Data & Images
Linkouts	BDGP expression data • GH08860 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0027560 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4104-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Tps1 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal Tps1a18 Tps1a19 Tps1b2 Tps1h10 Tps1jf5 Tps1sz31 Tps1sz72 lethal | larval stage, with Scer\GAL432B Tps1Scer\UAS.cCa lethal | larval stage | recessive Tps1k08903 lethal | pupal stage | heat sensitive, with Scer\GAL4hs.PB Tps1Scer\UAS.cCa lethal | recessive Tps1k08903 Other Phenotypes Allele visible, with Scer\GAL4GMR.PF Tps1Scer\UAS.cCa Phenotype manifest in Allele eye, with Scer\GAL4GMR.PF Tps1Scer\UAS.cCa ommatidium, with Scer\GAL4GMR.PF Tps1Scer\UAS.cCa
Classical Alleles ( 11 )
For All Classical Alleles Show
Allele of Tps1 Class Mutagen Stocks Known lesion Tps1k08903 P-element activity 2 Yes Tps1MI03087 1 -- Tps12407A natural population 0 -- Tps1303C natural population 0 -- Tps1a18 0 -- Tps1a19 0 -- Tps1b2 0 -- Tps1h10 0 -- Tps1jf5 0 -- Tps1sz31 0 -- Tps1sz72 0 --
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Tps1 Class Mutagen Stocks Known lesion Tps1GD1551 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Tps1KK104509 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Tps1NIG.4104R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Tps1Scer\UAS.cCa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)BSC295 (Christensen and Cook, 2007.5.8) Df(2L)dp-h19 (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988, Mathew et al., 2009) Df(2L)dp-h25 (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) Df(2L)dp-h28 (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988, Mathew et al., 2009, Mathew et al., 2009) Df(2L)ed-dp (Spradling et al., 1999, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988, BDGP Project Members, 1994-1999) Df(2L)Exel8011 (Ryder, 2004.4.26) Df(2L)M24F11 (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) Df(2L)M24F-B (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) Df(2L)sc19-1 (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) Df(2L)sc19-3 (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) Df(2L)sc19-11 (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) Df(2L)sc19-13 (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)
Not disrupted in	Df(2L)dp-cl-h3 (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) Df(2L)dp-h19 (Mathew et al., 2009) Df(2L)dp-h24 (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988, Mathew et al., 2009, Mathew et al., 2009) Df(2L)dp-h25 (Mathew et al., 2009, Mathew et al., 2009) Df(2L)ed1 (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) Df(2L)ED250 (Mathew et al., 2009, Mathew et al., 2009) Df(2L)ED251 (Mathew et al., 2009, Mathew et al., 2009) Df(2L)ED252 (Mathew et al., 2009, Mathew et al., 2009) Df(2L)ED3006-2L (Mathew et al., 2009, Mathew et al., 2009) Df(2L)Exel6010 (Mathew et al., 2009, Mathew et al., 2009) Df(2L)Exel9062 (Mathew et al., 2009, Mathew et al., 2009) Df(2L)sc19-4 (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) Df(2L)sc19-5 (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) Df(2L)sc19-6 (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) Df(2L)sc19-10 (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) Df(2L)sc19-12 (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) Df(2L)tkv3 (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1551} NA P{KK104509} NA P{NIG.4104R} NA P{UAS-Tps1.C} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}Tps1k08903 No miscellaneous insertions Mi{MIC}Tps1MI03087 NA
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
lipid particle inferred from direct assay (Beller et al., 2006)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity inferred from sequence or structural similarity with UniProtKB:Q07158 (FlyBase, 1992-) non-traceable author statement (Chen et al., 2002)
Biological Process
CV term Evidence References
trehalose biosynthetic process inferred from electronic annotation with InterPro:IPR001830, InterPro:IPR003337 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Tps1 - Art8 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tps1 - CG10949 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tps1 - CG12264 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tps1 - CG33303 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tps1 - CG4169 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tps1 - Gale anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tps1 - Nurf-38 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tps1 - pgant3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tps1 - porin anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Tps1 - α-Spec anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Tps1 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 59836 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0027560 DroID - A comprehensive database of gene and protein interactions. • FBgn0027560 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33642
Orthologs
OrthoDB Orthologs (33) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6FTWK1 Dipteran inclusive ortholog search EOG6K6GC9 Insect inclusive ortholog search EOG6THTP2 Arthropod inclusive ortholog search EOG6GB5N6 Metazoa inclusive ortholog search EOG6VF2R6
Orthologs in Drosophila Species (EOG6FTWK1)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Tps1     Drosophila simulans   Dsim\GD23282 Y   Drosophila sechellia   Dsec\GM18467 Y   Drosophila erecta   Dere\GG24998 Y   Drosophila yakuba   Dyak\GE18284 Y   Drosophila ananassae   Dana\GF21145 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA17960 Y   Drosophila persimilis   Dper\GL15110 Y   Drosophila willistoni   Dwil\GK24698 Y   Drosophila virilis   Dvir\GJ16123 Y   Drosophila mojavensis   Dmoj\GI22062 Y   Drosophila grimshawi   Dgri\GH13210 Y
Orthologs in non-Drosophila Dipterans (EOG6K6GC9)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL006446   Anopheles gambiae Malaria mosquito  Agam\AGAP008227   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ801662
Orthologs in non-Dipteran Insects (EOG6THTP2)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB45758   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG007392   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH17042   Atta cephalotes Leafcutter ant  Acep\ACEP24264   Camponotus floridanus Florida carpenter ant  Cflo\CFLO20948   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL14417   Linepithema humile Argentine ant  Lhum\LH25242   Pogonomyrmex barbatus Red harvester ant  Pbar\PB22125   Solenopsis invicta Red fire ant  Sinv\SINV16558   Acyrthosiphon pisum Pea aphid  Apim\ACYPI000405   Acyrthosiphon pisum Pea aphid  Apim\ACYPI007005   Bombyx mori Silkmoth  Bmor\BGIBMGA005182   Pediculus humanus Human body louse  Phum\PHUM612040   Tribolium castaneum Red flour beetle  Tcas\GLEAN_07883
Orthologs in non-Insect Arthropods (EOG6GB5N6)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_52079   Daphnia pulex Water flea  Dpux\Sfmbt1
Orthologs in non-Arthropod Metazoa (EOG6VF2R6)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\ZK54.2   Caenorhabditis elegans Nematode  Cele\tps-2
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD23282 Drosophila sechellia Dsec\GM18467 Drosophila erecta Dere\GG24998 Drosophila yakuba Dyak\GE18284 Drosophila ananassae Dana\GF21145 Drosophila pseudoobscura pseudoobscura Dpse\GA17960 Drosophila persimilis Dper\GL15110 Drosophila willistoni Dwil\GK24698 Drosophila virilis Dvir\GJ16123 Drosophila mojavensis Dmoj\GI22062 Drosophila grimshawi Dgri\GH13210
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
Bloomington	36190 y1 w*; Mi{MIC}Tps1MI03087 10838 y1 w67c23; P{lacW}Tps1k08903/CyO
Kyoto	111252 yd2 w1118 P{ey-FLP.N}2 P{GMR-lacZ.C(38.1)}TPN1; P{lacW}Tps1k08903 P{neoFRT}40A/CyO y+
Genomic Clones ( 1 )
	BACR28K16 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 264 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH08860 RE05454
Other clones	DPiM_GH08860
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH01033 GH02532 GH04014 GH05054 GH05155 GH05889 GH06215 GH06525 GH07108 GH07653 GH08184 GH09804 GH10935 GH11246 GH13740 GH13917 GH13987 GH15846 GH16418 GH16860 GH16866 GH17205 GH17228 GH17594 GH18412 GH18643 GH18770 GH19621 GH19622 GH20147 GH20401 GH20937 GH22025 GH22230 GH22382 GH23281 GH23931 GH23947 GH24227 GH24401 GH25480 GH25773 GH26456 GH27958 GH28671 HL01187 LP06603 LP07814 LP11496 LP16182 LP22940 RE05387 RE11186 RE15333 RE17403 RE21096 RE26873 RE55192 RH02653 RH03451 RH03796 RH04124 RH17886 RH24085 RH24712 RH24991 RH28641 RH29996 RH30765 RH31065 RH33012 RH35612 RH36993 RH40791 RH42758 RH46062 RH46184 RH47073 RH48460 RH48550 RH50125 RH51303 RH57791 RH59132 RH59950 RH61641 RH63894 RH65992 RH66058 RH66514 RH68487 RH68889 RH71153 RH71456 RH71574 RH72524 RH72932
Other clones	Dmel_dig_018576_0602_1771 Dmel_neb_011834_0915_0273 EK144545 EK190059 EK201549 GH08323 GH08794 GH09151 GH09494 GH12856 GH14304 GH18734 GH19030 GH24330 GH26658 HL03438 HL08004 IP01872 IP11721 IP14138 IP14238 LP09032 RE27482 RE45955 RE49893 RE72108 RE72130 RH01003 RH03475 RH04620 RH04677 RH06126 RH06289 RH06343 RH06726 RH06788 RH08916 RH20909 RH21054 RH22258 RH24046 RH25235 RH28522 RH32748 RH33715 RH33773 RH35693 RH37095 RH39733 RH42093 RH44407 RH45347 RH47878 RH48560 RH52223 RH55706 RH59945 RH64034 RH65776 RH69772 RP003010787 RP003020365 RP003027094 RP003036486 RP003039915 RP003046016 RP003049853 RP003064282 RP003081128 RP003084438 RP003128127 RP003129508 RP003130268 RP003131312 RP003136979 RP003143635 RP003145980 RP003147574 RP003155079 RP003157454 RP003159455 RP003159864 RP003187172 RP003190222 RP003190959 RP003201294 RP003209888 RP003222301 RP003227182 RP003240749 RP003246724 RP003253617 RP003255960 RP003256408 RP003259298 RP003260102 RP003263044 RP003264818 RP003277161 RP003278703 RP003281694 RP003286069 RP003298309 RP003300102 RP003301134 RP003302397 RP003303117 RP003307164 RP003309422 RP003313139 RP003314347 RP003314630 RP003318553 RP003323906 RP003323939 RP003326185 RP003328346 RP003329158 RP003336701 RP003339908 RP003340476 RP003341616 RP003344653 RP003344756 RP003352593 RP003353958 RP003355040 RP003365747 RP003382759 RP003402767 RP003405973 RP003426454 RP003428916 RP003445699 RP003448601 RP003491011 RP003505586 RP003510556 RP003518654 RP003531311 RP003535630 RP003542780 RP003543405 RP003547035 RP003564811 RP003574848 RP003580946 RP003591793 RP003602790 RP003602874 RP003607027 RP003610208 RP003612968 RP003613047 RP003634813 RP003638667 RP003643406 RP003643734 RP003652517 RP003653487 RP003656663 RP003671023 RP003678500 RP003682878
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0027560 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33642
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: tps1 BcDNA:GH08860 (Chen et al., 2002)
Source for database merge of	Source for merge of: l(2)k08903 BcDNA:GH08860 (Chen et al., 2002) Source for merge of: Tps1 l(2)24Ea (Dean, 2003.6.5)
Additional comments
Other Comments
	Overexpression of Tps1 results in increased tolerance to anoxia and an increase in trehalose levels. (Chen et al., 2002) In vitro experiments showed that trehalose reduced protein aggregation caused by anoxia. (Chen et al., 2002) Upon induction of Tps1, trehalose increased and this was associated with increased tolerance to anoxia. (Chen et al., 2002) Homozygous Tps1 mutant leads to lethality at an early larval stage. (Chen et al., 2002) Gene isolated in a screen of the second chromosome identifying mutants affecting disc morphology. (Roch et al., 1998)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_134983 RefSeq (Proteins) • NP_608827 DDBJ / EMBL / GenBank • AAD38628 AAF51020 AAX33476 AF145653 AI109620 AI402150 AQ034018 BI165535 BT021328 Entrez Gene - A searchable database of RefSeq genes. • 33642 UniProtKB/TrEMBL • Q9Y119
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Glycosyl transferase, family 20 (IPR001830) Trehalose-phosphatase (IPR003337) HAD-superfamily hydrolase, subfamily IIB (IPR006379) HAD-like domain (IPR023214) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GH08860
Linkouts
	BioGRID - A database of protein and genetic interactions • 59836 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0027560 DroID - A comprehensive database of gene and protein interactions. • FBgn0027560 DRSC - Results from RNAi screens. • FBgn0027560 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0027560 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4104-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0027560 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33642 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33642 modMine - Data generated by the modENCODE project. • FBgn0027560
Synonyms & Secondary IDs ( 20 )
Reported As
Symbol Synonym	BcDNA:GH08860 (Wang et al., 2004, Zou et al., 2000, ) CG4104 (Sezgin et al., 2004, Keleman et al., 2009.8.5, Cammarato et al., 2011) CG4104 PA (Danchin et al., 2006) dtps1 (Chen et al., 2003) jf5 (Dean, 2003.6.5, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) l(2)24Ea   l(2)jf4   l(2)jf5   l(2)k08903 (Spradling et al., 1999, Roch et al., 1998, ) TPS (Sezgin and Eanes, 2004) tps1 (Chen and Haddad, 2004, Chen et al., 2002, Chen et al., 2002, Feala et al., 2008, Stergiopoulos et al., 2009) Tps1 (Beller et al., 2006, Christensen and Cook, 2007.5.8, Flowers et al., 2007, Xun et al., 2009, Mathew et al., 2009, Domanitskaya et al., 2007, Wasbrough et al., 2010, Japanese National Institute of Genetics, 2012.5.21) TreS (Sezgin et al., 2004)
Name Synonym	lethal(2)24Ea   Trehalos-6-phosphate synthase (Sezgin and Eanes, 2004) trehalose-6-phosphate synthase (Chen et al., 2002, Musselman et al., 2011) Trehalose-6-phosphate synthase 1 (Chen et al., 2002, Xun et al., 2009, Cammarato et al., 2011) trehalose-6-phosphate synthase 1 (Stergiopoulos et al., 2009, Yuen et al., 2008) trehalose-phosphate synthase (Feala et al., 2008) trehalose synthase (Yuen et al., 2008)
Secondary FlyBase IDs
	FBgn0001908 FBgn0022028
References ( 45 )
Generate a list of	All references relating to this gene ( 45 )
List References by type	Research paper  ( 19 ) Supplementary material  ( 7 ) Review  ( 1 ) Personal communication to FlyBase  ( 9 ) Abstract  ( 2 ) FlyBase analysis  ( 1 ) Stock list  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 ) Book  ( 1 )
Recent research papers ( 2 )
	Kern et al., 2012, Insect Mol. Biol. 21(4): 456--471 Trehalose-6-phosphate synthase from the cat flea Ctenocephalides felis and Drosophila melanogaster: gene identification, cloning, heterologous functional expression and identification of inhibitors by high throughput screening. [FBrf0218846] Musselman et al., 2011, Dis. Model Mech. 4(6): 842--849 A high-sugar diet produces obesity and insulin resistance in wild-type Drosophila. [FBrf0216626] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...