• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • CytoSearch
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Downloads:
  • Precomputed files
  • Archived data
  • Releases (FTP)
  • Genomes (FTP)
  • AAA data (FTP)
  • Lists:
  • Transposons (Dmel)
  • Transposons (other)
  • Vectors & Constructs
  • Anatomical Terms
  • Map Conversion
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Other links:
  • BDGP
  • DGRC
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\CG3523

General Information
Symbol	Dmel\CG3523	Species	D. melanogaster
Name		Annotation symbol	CG3523
Feature type	protein_coding_gene	FlyBase ID	FBgn0027571
Gene Model Status	Current	Stock availability	10 publicly available
Also Known As	FAS, Fatty acid synthase, BcDNA:gh07626
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	23C5-23D1	Sequence location	2L:3,056,615..3,068,184 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG3523 (FBgn0027571). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: fatty acid synthase activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: oxidation-reduction process; biosynthetic process. 15 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Acyl carrier protein-like; Acyl transferase; Acyl transferase domain; Acyl transferase/acyl hydrolase/lysophospholipase; Alcohol dehydrogenase, C-terminal; Beta-ketoacyl synthase; Beta-ketoacyl synthase, C-terminal; Beta-ketoacyl synthase, N-terminal; Beta-ketoacyl synthase, active site; Fatty acid synthase, domain 2; GroES-like; Malonyl-CoA ACP transacylase, ACP-binding; NAD(P)-binding domain; Phosphopantetheine-binding; Polyketide synthase, KR; Polyketide synthase, enoylreductase; Polyketide synthase/Fatty acid synthase, KR; Short-chain dehydrogenase/reductase SDR; Thioesterase; Thiolase-like; Thiolase-like, subgroup. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of very low expression. Peak expression observed within 18-24 hour embryonic stages, during early larval stages, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, adult Malpighian tubules, adult heart, larval/adult fat body, larval trachea, adult spermathecae, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval Malpighian tubules, larval/adult salivary gland, adult ovary, adult testis, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1624549_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of CG3523. Gene sequence location is 2L:3056615..3068184.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10	Controlled Vocabulary Terms day 42 of adulthood day 41 of adulthood day 30 of adulthood day 49 of adulthood day 17 of adulthood day 45 of adulthood day 8 of adulthood day 26 of adulthood day 21 of adulthood day 13 of adulthood day 25 of adulthood day 22 of adulthood day 20 of adulthood day 39 of adulthood day 7 of adulthood day 36 of adulthood day 11 of adulthood day 37 of adulthood day 27 of adulthood day 18 of adulthood day 19 of adulthood day 28 of adulthood day 9 of adulthood day 29 of adulthood adult heart day 40 of adulthood day 16 of adulthood day 24 of adulthood day 15 of adulthood day 33 of adulthood day 43 of adulthood day 47 of adulthood day 38 of adulthood day 32 of adulthood day 48 of adulthood day 23 of adulthood day 35 of adulthood day 12 of adulthood day 10 of adulthood day 31 of adulthood day 34 of adulthood day 44 of adulthood day 14 of adulthood day 46 of adulthood
FB2012_01	Sequence features BKN27330 HFA00268
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 23C5-23D1   Limits computationally determined from genome sequence between P{PZ}lilli00632 and P{PZ}toc01361
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG3523 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	DGC clone appears problematic (GH07626): incomplete CDS.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG3523-RA FBtr0077659  NM_134904   8612   2438 CG3523-RB FBtr0290093  NM_001144306   8727   2544
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG3523-PA   FBpp0077343   266.4   2438   6.31     NP_608748   AAF51148 CG3523-PB   FBpp0288532   278.5   2544   6.67     NP_001137778   ACL82985
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Beta-ketoacyl synthase (IPR000794) Thioesterase (IPR001031) Acyl transferase domain (IPR001227) Short-chain dehydrogenase/reductase SDR (IPR002198) Acyl carrier protein-like (IPR009081) Alcohol dehydrogenase, C-terminal (IPR013149) Polyketide synthase, KR (IPR013968) Beta-ketoacyl synthase, active site (IPR018201) GroES-like (IPR011032) Beta-ketoacyl synthase, N-terminal (IPR014030) Beta-ketoacyl synthase, C-terminal (IPR014031) Acyl transferase (IPR014043) NAD(P)-binding domain (IPR016040) Acyl transferase/acyl hydrolase/lysophospholipase (IPR016035) Malonyl-CoA ACP transacylase, ACP-binding (IPR016036) Thiolase-like, subgroup (IPR016038) Thiolase-like (IPR016039) Polyketide synthase, enoylreductase (IPR020843) Polyketide synthase/Fatty acid synthase, KR (IPR020842) Phosphopantetheine-binding (IPR006163) Fatty acid synthase, domain 2 (IPR023102)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA696450   AA699056   AA802643   AA803739   AE014134 AAF51148   AE014134 ACL82985   AF145643 AAD38618   AF171776   AF171846   AI063727   AI106701   AI107581   AI107790   AI108098   AI108135   AI108172   AI108210   AI108612   AI108640   AI108958   AI109094   AI110045   AI113901   AI134769   AI135035   AI257518   AI260130   AI260539   AI292610   AI292667   AI292679   AI294109   AI294168   AI295052   AI295126   AI295813   AI386742   AI387247   AI387249   AI387498   AI387745   AI387775   AI387787   AI387874   AI388664   AI389456   AI389562   AI389727   AI389915   AI402090   AI402728   AI402897   AI403382   AI403726   AI404564   AI404854   AI405354   AI514012   AI516997   AI532126   AI532355   AI534685   AI541583   AI542678   AX153650   BF490447   BG632245   BG632399   BG632952   BG633415   BG633441   BG635852   BG637395   BG640265   BH614987   BI141916   BI355057   BI355415   BI569373   BI570498   BI590480   BI612141   BI615486   BI620621   BI632925   BI633553   BI637215   BI638764   BI641969   BT050523   CK131890   CK132038   CK132501   CK605314   CK605315   CK605457   CK605458   CK657293   CK658654   CK658945   CK661674   CO154270   CO155979   CO156758   CO264828   CO265766   CO267626   CO267962   CO277008   CO277395   CO283383   CO288637   CO291168   CO291758   CO296502   CO316447   CO329709   CO336630   CO337085   CO345155   CZ474170   CZ475452   CZ475453   CZ488273   CZ488274   EC059120   EC067350   EC075110   EC080586   EC081583   EC083108   EC083189   EC087191   EC199061   EC209153   EC209851   EC220699   EC222386   EC237242   EC240436   EC246924   EC249831   EC262177   EC264255   EC265106   EC266444   EC267566   EL872674   EL883580   EL883774   EL883898   ES690530   ES695684   ES695687   ES695702   ES695710   ES695722   ES696492   ES696496   EV576994   EV592395   EV596589   EV597158   EV597349   EV599244
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7KML1 Q9VQL7 B7Z001
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0027571    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0027571 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of very low expression. Peak expression observed within 18-24 hour embryonic stages, during early larval stages, in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0027571 expression level Developmental Stage   Expression Level embryo 00-02hr    385 embryo 02-04hr    232 embryo 04-06hr    62 embryo 06-08hr    122 embryo 08-10hr    179 embryo 10-12hr    291 embryo 12-14hr    492 embryo 14-16hr    611 embryo 16-18hr    1824 embryo 18-20hr    10009 embryo 20-22hr    21403 embryo 22-24hr    26891 larva L1    11935 larva L2    15721 larva L3 12hr old    22443 larva L3 puffstage 1-2    8533 larva L3 puffstage 3-6    2668 larva L3 puffstage 7-9    700 white prepupae new    718 white prepupae 12hr    1227 white prepupae 24hr    1064 pupae 2d postWPP    1031 pupae 3d postWPP    586 pupae 4d postWPP    1540 adult male 01day    11805 adult male 05day    11760 adult male 30day    12573 adult female 01day    6926 adult female 05day    8802 adult female 30day    9860 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (385) embryo 02-04hr  (232) embryo 04-06hr    62 embryo 06-08hr  (122) embryo 08-10hr  (179) embryo 10-12hr  (291) embryo 12-14hr  (492) embryo 14-16hr  (611) embryo 16-18hr  (1824) embryo 18-20hr  (10009) embryo 20-22hr  (21403) embryo 22-24hr  (26891) larva L1  (11935) larva L2  (15721) larva L3 12hr old  (22443) larva L3 puffstage 1-2  (8533) larva L3 puffstage 3-6  (2668) larva L3 puffstage 7-9  (700) white prepupae new  (718) white prepupae 12hr  (1227) white prepupae 24hr  (1064) pupae 2d postWPP  (1031) pupae 3d postWPP  (586) pupae 4d postWPP  (1540) adult male 01day  (11805) adult male 05day  (11760) adult male 30day  (12573) adult female 01day  (6926) adult female 05day  (8802) adult female 30day  (9860) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    385 embryo 02-04hr    232 embryo 04-06hr    62 embryo 06-08hr    122 embryo 08-10hr    179 embryo 10-12hr    291 embryo 12-14hr    492 embryo 14-16hr    611 embryo 16-18hr  (1824) embryo 18-20hr  (10009) embryo 20-22hr  (21403) embryo 22-24hr  (26891) larva L1  (11935) larva L2  (15721) larva L3 12hr old  (22443) larva L3 puffstage 1-2  (8533) larva L3 puffstage 3-6  (2668) larva L3 puffstage 7-9    700 white prepupae new    718 white prepupae 12hr    1227 white prepupae 24hr    1064 pupae 2d postWPP    1031 pupae 3d postWPP    586 pupae 4d postWPP  (1540) adult male 01day  (11805) adult male 05day  (11760) adult male 30day  (12573) adult female 01day  (6926) adult female 05day  (8802) adult female 30day  (9860) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    385 embryo 02-04hr    232 embryo 04-06hr    62 embryo 06-08hr    122 embryo 08-10hr    179 embryo 10-12hr    291 embryo 12-14hr    492 embryo 14-16hr    611 embryo 16-18hr    1824 embryo 18-20hr  10009 embryo 20-22hr  (21403) embryo 22-24hr  (26891) larva L1  (11935) larva L2  (15721) larva L3 12hr old  (22443) larva L3 puffstage 1-2    8533 larva L3 puffstage 3-6    2668 larva L3 puffstage 7-9    700 white prepupae new    718 white prepupae 12hr    1227 white prepupae 24hr    1064 pupae 2d postWPP    1031 pupae 3d postWPP    586 pupae 4d postWPP    1540 adult male 01day  (11805) adult male 05day  (11760) adult male 30day  (12573) adult female 01day    6926 adult female 05day    8802 adult female 30day    9860 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    385 embryo 02-04hr    232 embryo 04-06hr    62 embryo 06-08hr    122 embryo 08-10hr    179 embryo 10-12hr    291 embryo 12-14hr    492 embryo 14-16hr    611 embryo 16-18hr    1824 embryo 18-20hr    10009 embryo 20-22hr    21403 embryo 22-24hr    26891 larva L1    11935 larva L2    15721 larva L3 12hr old    22443 larva L3 puffstage 1-2    8533 larva L3 puffstage 3-6    2668 larva L3 puffstage 7-9    700 white prepupae new    718 white prepupae 12hr    1227 white prepupae 24hr    1064 pupae 2d postWPP    1031 pupae 3d postWPP    586 pupae 4d postWPP    1540 adult male 01day    11805 adult male 05day    11760 adult male 30day    12573 adult female 01day    6926 adult female 05day    8802 adult female 30day    9860 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0027571 expression level Developmental Stage   Expression Level embryo 00-02hr    385 embryo 02-04hr    232 embryo 04-06hr    62 embryo 06-08hr    122 embryo 08-10hr    179 embryo 10-12hr    291 embryo 12-14hr    492 embryo 14-16hr    611 embryo 16-18hr    1824 embryo 18-20hr    10009 embryo 20-22hr    21403 embryo 22-24hr    26891 larva L1    11935 larva L2    15721 larva L3 12hr old    22443 larva L3 puffstage 1-2    8533 larva L3 puffstage 3-6    2668 larva L3 puffstage 7-9    700 white prepupae new    718 white prepupae 12hr    1227 white prepupae 24hr    1064 pupae 2d postWPP    1031 pupae 3d postWPP    586 pupae 4d postWPP    1540 adult male 01day    11805 adult male 05day    11760 adult male 30day    12573 adult female 01day    6926 adult female 05day    8802 adult female 30day    9860 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (385) embryo 02-04hr  (232) embryo 04-06hr    62 embryo 06-08hr  122 embryo 08-10hr  (179) embryo 10-12hr  (291) embryo 12-14hr  (492) embryo 14-16hr  (611) embryo 16-18hr  (1824) embryo 18-20hr  (10009) embryo 20-22hr  (21403) embryo 22-24hr  (26891) larva L1  (11935) larva L2  (15721) larva L3 12hr old  (22443) larva L3 puffstage 1-2  (8533) larva L3 puffstage 3-6  (2668) larva L3 puffstage 7-9  (700) white prepupae new  (718) white prepupae 12hr  (1227) white prepupae 24hr  (1064) pupae 2d postWPP  (1031) pupae 3d postWPP  (586) pupae 4d postWPP  (1540) adult male 01day  (11805) adult male 05day  (11760) adult male 30day  (12573) adult female 01day  (6926) adult female 05day  (8802) adult female 30day  (9860) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    385 embryo 02-04hr    232 embryo 04-06hr    62 embryo 06-08hr    122 embryo 08-10hr    179 embryo 10-12hr    291 embryo 12-14hr    492 embryo 14-16hr    611 embryo 16-18hr  1824 embryo 18-20hr  (10009) embryo 20-22hr  (21403) embryo 22-24hr  (26891) larva L1  (11935) larva L2  (15721) larva L3 12hr old  (22443) larva L3 puffstage 1-2  (8533) larva L3 puffstage 3-6  (2668) larva L3 puffstage 7-9    700 white prepupae new    718 white prepupae 12hr    1227 white prepupae 24hr    1064 pupae 2d postWPP    1031 pupae 3d postWPP    586 pupae 4d postWPP  1540 adult male 01day  (11805) adult male 05day  (11760) adult male 30day  (12573) adult female 01day  (6926) adult female 05day  (8802) adult female 30day  (9860) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    385 embryo 02-04hr    232 embryo 04-06hr    62 embryo 06-08hr    122 embryo 08-10hr    179 embryo 10-12hr    291 embryo 12-14hr    492 embryo 14-16hr    611 embryo 16-18hr    1824 embryo 18-20hr  10009 embryo 20-22hr  (21403) embryo 22-24hr  (26891) larva L1  11935 larva L2  15721 larva L3 12hr old  (22443) larva L3 puffstage 1-2    8533 larva L3 puffstage 3-6    2668 larva L3 puffstage 7-9    700 white prepupae new    718 white prepupae 12hr    1227 white prepupae 24hr    1064 pupae 2d postWPP    1031 pupae 3d postWPP    586 pupae 4d postWPP    1540 adult male 01day  11805 adult male 05day  11760 adult male 30day  12573 adult female 01day    6926 adult female 05day    8802 adult female 30day    9860 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    385 embryo 02-04hr    232 embryo 04-06hr    62 embryo 06-08hr    122 embryo 08-10hr    179 embryo 10-12hr    291 embryo 12-14hr    492 embryo 14-16hr    611 embryo 16-18hr    1824 embryo 18-20hr    10009 embryo 20-22hr    21403 embryo 22-24hr    26891 larva L1    11935 larva L2    15721 larva L3 12hr old    22443 larva L3 puffstage 1-2    8533 larva L3 puffstage 3-6    2668 larva L3 puffstage 7-9    700 white prepupae new    718 white prepupae 12hr    1227 white prepupae 24hr    1064 pupae 2d postWPP    1031 pupae 3d postWPP    586 pupae 4d postWPP    1540 adult male 01day    11805 adult male 05day    11760 adult male 30day    12573 adult female 01day    6926 adult female 05day    8802 adult female 30day    9860 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0027571    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0027571 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, adult Malpighian tubules, adult heart, larval/adult fat body, larval trachea, adult spermathecae, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval Malpighian tubules, larval/adult salivary gland, adult ovary, adult testis, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0027571 expression level Tissue   Expression Level Larval Central Nervous System    1369.125 Larval Midgut    2930.8 Larval Hindgut    1257.4 Larval Malpighian Tubules    254.7 Larval Fat Body    2448.2 Larval Salivary Gland    413.9 Larval Trachea    865.4 Larval Carcass    476.75 Adult Head    3363.8 Adult Eye    3116.55 Adult Brain    1140.9 Adult Thoracic-Abdominal Ganglion    1229.5 Adult Crop    5298.4 Adult Midgut    626.4 Adult Hindgut    2022.4 Adult Malpighian Tubules    669.4 Adult Fat Body    6204.5 Adult Salivary Gland    162.6 Adult Heart    6362.95 Adult VirginFemale Spermatheca    6241 Adult InseminatedFemale Spermatheca    6349.5 Adult Ovary    435.7 Adult Testis    184.7 Adult Male Accessory Gland    97.6 Adult Carcass    6042.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1369.125) Larval Midgut  (2930.8) Larval Hindgut  (1257.4) Larval Malpighian Tubules    254.7 Larval Fat Body  (2448.2) Larval Salivary Gland    413.9 Larval Trachea  (865.4) Larval Carcass    476.75 Adult Head  (3363.8) Adult Eye  (3116.55) Adult Brain  (1140.9) Adult Thoracic-Abdominal Ganglion  (1229.5) Adult Crop  (5298.4) Adult Midgut  (626.4) Adult Hindgut  (2022.4) Adult Malpighian Tubules  (669.4) Adult Fat Body  (6204.5) Adult Salivary Gland    162.6 Adult Heart  (6362.95) Adult VirginFemale Spermatheca  (6241) Adult InseminatedFemale Spermatheca  (6349.5) Adult Ovary    435.7 Adult Testis    184.7 Adult Male Accessory Gland    97.6 Adult Carcass  (6042.7) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (1369.125) Larval Midgut  (2930.8) Larval Hindgut  (1257.4) Larval Malpighian Tubules    254.7 Larval Fat Body  (2448.2) Larval Salivary Gland    413.9 Larval Trachea    865.4 Larval Carcass    476.75 Adult Head  (3363.8) Adult Eye  (3116.55) Adult Brain  (1140.9) Adult Thoracic-Abdominal Ganglion  (1229.5) Adult Crop  (5298.4) Adult Midgut    626.4 Adult Hindgut  (2022.4) Adult Malpighian Tubules    669.4 Adult Fat Body  (6204.5) Adult Salivary Gland    162.6 Adult Heart  (6362.95) Adult VirginFemale Spermatheca  (6241) Adult InseminatedFemale Spermatheca  (6349.5) Adult Ovary    435.7 Adult Testis    184.7 Adult Male Accessory Gland    97.6 Adult Carcass  (6042.7) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1369.125 Larval Midgut    2930.8 Larval Hindgut    1257.4 Larval Malpighian Tubules    254.7 Larval Fat Body    2448.2 Larval Salivary Gland    413.9 Larval Trachea    865.4 Larval Carcass    476.75 Adult Head    3363.8 Adult Eye    3116.55 Adult Brain    1140.9 Adult Thoracic-Abdominal Ganglion    1229.5 Adult Crop    5298.4 Adult Midgut    626.4 Adult Hindgut    2022.4 Adult Malpighian Tubules    669.4 Adult Fat Body    6204.5 Adult Salivary Gland    162.6 Adult Heart    6362.95 Adult VirginFemale Spermatheca    6241 Adult InseminatedFemale Spermatheca    6349.5 Adult Ovary    435.7 Adult Testis    184.7 Adult Male Accessory Gland    97.6 Adult Carcass    6042.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0027571 expression level Tissue   Expression Level Larval Central Nervous System    1369.125 Larval Midgut    2930.8 Larval Hindgut    1257.4 Larval Malpighian Tubules    254.7 Larval Fat Body    2448.2 Larval Salivary Gland    413.9 Larval Trachea    865.4 Larval Carcass    476.75 Adult Head    3363.8 Adult Eye    3116.55 Adult Brain    1140.9 Adult Thoracic-Abdominal Ganglion    1229.5 Adult Crop    5298.4 Adult Midgut    626.4 Adult Hindgut    2022.4 Adult Malpighian Tubules    669.4 Adult Fat Body    6204.5 Adult Salivary Gland    162.6 Adult Heart    6362.95 Adult VirginFemale Spermatheca    6241 Adult InseminatedFemale Spermatheca    6349.5 Adult Ovary    435.7 Adult Testis    184.7 Adult Male Accessory Gland    97.6 Adult Carcass    6042.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1369.125) Larval Midgut  (2930.8) Larval Hindgut  (1257.4) Larval Malpighian Tubules    254.7 Larval Fat Body  (2448.2) Larval Salivary Gland    413.9 Larval Trachea  (865.4) Larval Carcass    476.75 Adult Head  (3363.8) Adult Eye  (3116.55) Adult Brain  (1140.9) Adult Thoracic-Abdominal Ganglion  (1229.5) Adult Crop  (5298.4) Adult Midgut  626.4 Adult Hindgut  (2022.4) Adult Malpighian Tubules  669.4 Adult Fat Body  (6204.5) Adult Salivary Gland    162.6 Adult Heart  (6362.95) Adult VirginFemale Spermatheca  (6241) Adult InseminatedFemale Spermatheca  (6349.5) Adult Ovary    435.7 Adult Testis    184.7 Adult Male Accessory Gland    97.6 Adult Carcass  (6042.7) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  1369.125 Larval Midgut  (2930.8) Larval Hindgut  1257.4 Larval Malpighian Tubules    254.7 Larval Fat Body  (2448.2) Larval Salivary Gland    413.9 Larval Trachea    865.4 Larval Carcass    476.75 Adult Head  (3363.8) Adult Eye  (3116.55) Adult Brain  1140.9 Adult Thoracic-Abdominal Ganglion  1229.5 Adult Crop  (5298.4) Adult Midgut    626.4 Adult Hindgut  (2022.4) Adult Malpighian Tubules    669.4 Adult Fat Body  (6204.5) Adult Salivary Gland    162.6 Adult Heart  (6362.95) Adult VirginFemale Spermatheca  (6241) Adult InseminatedFemale Spermatheca  (6349.5) Adult Ovary    435.7 Adult Testis    184.7 Adult Male Accessory Gland    97.6 Adult Carcass  (6042.7) Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1369.125 Larval Midgut    2930.8 Larval Hindgut    1257.4 Larval Malpighian Tubules    254.7 Larval Fat Body    2448.2 Larval Salivary Gland    413.9 Larval Trachea    865.4 Larval Carcass    476.75 Adult Head    3363.8 Adult Eye    3116.55 Adult Brain    1140.9 Adult Thoracic-Abdominal Ganglion    1229.5 Adult Crop    5298.4 Adult Midgut    626.4 Adult Hindgut    2022.4 Adult Malpighian Tubules    669.4 Adult Fat Body    6204.5 Adult Salivary Gland    162.6 Adult Heart    6362.95 Adult VirginFemale Spermatheca    6241 Adult InseminatedFemale Spermatheca    6349.5 Adult Ovary    435.7 Adult Testis    184.7 Adult Male Accessory Gland    97.6 Adult Carcass    6042.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    3363.8   NA  Eye    3116.55   NA  Brain    1140.9   1369.125  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    1229.5   NA  Crop    5298.4   2930.8  Midgut    626.4   1257.4  Hindgut    2022.4   254.7  Malpighian Tubules    669.4   2448.2  Fat Body    6204.5   413.9  Salivary Gland    162.6   NA  Heart    6362.95   865.4  Trachea    NA   NA  VirginFemale Spermatheca    6241   NA  InseminatedFemale Spermatheca    6349.5   NA  Ovary    435.7   NA  Testis    184.7   NA  Male Accessory Gland    97.6   476.75  Carcass    6042.7 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_20
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0027571 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3523-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CG3523GD14739 Other Phenotypes Allele increased cell death CG3523dsRNA.cRa Phenotype manifest in Allele
Classical Alleles ( 9 )
For All Classical Alleles Show
Allele of CG3523 Class Mutagen Stocks Known lesion CG35235-HA-2771 1 -- CG3523d02216 1 -- CG3523d06961 P-element activity 1 -- CG3523KG03696 P-element activity 1 -- CG3523NP0870 1 -- CG3523NP5166 1 -- CG3523d04847 P-element activity 0 -- CG3523f05657 piggyBac transposase 0 -- CG3523SH2254 0 --
Alleles Carried on Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG3523 Class Mutagen Stocks Known lesion CG3523GD14739 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG3523HM05141 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG3523HMS01524 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG3523KK107330 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG3523dsRNA.cRa in vitro construct - RNAi 0 Yes CG3523GD17144 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel7015 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD14739} NA P{GD17144} NA P{KK107330} NA P{TRiP.HM05141} NA P{TRiP.HMS01524} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap binary system P{GawB}CG3523NP0870 No P{GawB}CG3523NP5166 No miscellaneous insertions P{RS5}CG35235-HA-2771 NA P{SUPor-P}CG3523KG03696 NA P{SUPor-P}KG02138 NA P{UASp-YFP.Rab10.T23N}15 NA PBac{WH}CG3523f05657 NA insertion of mobile activating element P{XP}CG3523d02216 NA P{XP}CG3523d04847 NA P{XP}CG3523d06961 NA insertion of enhancer trap P{lacW}CG3523SH2254 No P{lacW}l(2)SH1385SH1385 No
Gene Ontology: Function, Process & Cellular Component ( 17 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
lipid particle inferred from direct assay (Beller et al., 2006, Beller et al., 2006)
Terms Based on Predictions or Assertions ( 16 terms )
Molecular Function
CV term Evidence References
3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity inferred from electronic annotation with InterPro:IPR023102 (FlyBase Curators et al., 2004-) 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity inferred from electronic annotation with InterPro:IPR023102 (FlyBase Curators et al., 2004-) 3-oxoacyl-[acyl-carrier-protein] synthase activity inferred from electronic annotation with InterPro:IPR023102 (FlyBase Curators et al., 2004-) [acyl-carrier-protein] S-acetyltransferase activity inferred from electronic annotation with InterPro:IPR023102 (FlyBase Curators et al., 2004-) [acyl-carrier-protein] S-malonyltransferase activity inferred from electronic annotation with InterPro:IPR023102 (FlyBase Curators et al., 2004-) acyl carrier activity inferred from electronic annotation with InterPro:IPR009081 (FlyBase Curators et al., 2004-) cofactor binding inferred from electronic annotation with InterPro:IPR006163 (FlyBase Curators et al., 2004-) enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity inferred from electronic annotation with InterPro:IPR023102 (FlyBase Curators et al., 2004-) fatty acid synthase activity inferred from sequence or structural similarity with EMBL:U29344 (FlyBase, 1992-) myristoyl-[acyl-carrier-protein] hydrolase activity inferred from electronic annotation with InterPro:IPR023102 (FlyBase Curators et al., 2004-) nucleotide binding inferred from electronic annotation with InterPro:IPR016040 (FlyBase Curators et al., 2004-) oleoyl-[acyl-carrier-protein] hydrolase activity inferred from electronic annotation with InterPro:IPR023102 (FlyBase Curators et al., 2004-) palmitoyl-[acyl-carrier-protein] hydrolase activity inferred from electronic annotation with InterPro:IPR023102 (FlyBase Curators et al., 2004-) zinc ion binding inferred from electronic annotation with InterPro:IPR013149 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
biosynthetic process inferred from electronic annotation with InterPro:IPR000794, InterPro:IPR001031 (FlyBase Curators et al., 2004-) oxidation-reduction process inferred from electronic annotation with InterPro:IPR013149, InterPro:IPR023102 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG3523 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0027571 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33524
Orthologs
Genome-wide drosophilid orthologs	Dere\GG24920 Dgri\GH10963 Dpse\GA17497 Dyak\GE18210
Curated drosophilid orthologs	Dpse\GA17497
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL001194-PA Aedes aegypti (mosquito) AGAP009176-PA Anopheles gambiae (mosquito) XP_396268.2 Apis mellifera (honey bee) XP_001945190.1 Acyrthosiphon pisum (pea aphid) 108803 Branchiostoma floridae (lancelet) 87410 Branchiostoma floridae (lancelet) XP_001898484.1 Brugia malayi (roundworm nematode) BGIBMGA004655-PA Bombyx mori (silk worm) ENSBTAP00000052914 Bos taurus (bovine) CN12046 Caenorhabditis brenneri (small nematode) CN20040 Caenorhabditis brenneri (small nematode) CBP31596 Caenorhabditis briggsae (nematode) CE42777 Caenorhabditis elegans (worm) ENSCAFP00000009039 Canis familiaris (dog) JA02513 Caenorhabditis japonica (nematode) CPIJ005595 Culex pipens (mosquito) ENSCPOP00000002086 Cavia porcellus (guinea pig) RP37939 Caenorhabditis remanei (nematode) 102987 Capitella spl (polychaete worm) DDB0234163 Dictyostelium discoideum (amoeba) ENSDARP00000090540 Danio rerio (zebra fish) ENSDARP00000090546 Danio rerio (zebra fish) ENSECAP00000017442 Equus caballus (horse) ENSGACP00000002882 Gymnopilus aculeatus (mushroom) ENSGALP00000038133 Gallus gallus (chicken) 99033 Hypsipyla robusta (cedar shoot borer) ENSP00000304592 Homo sapiens (human) ISCW009053-PA Ixodes scapularis (deer tick) 235996 Lottia gigantea (owl limpet) ENSMODP00000004189 Monodelphis domestica (gray opossum) ENSMMUP00000016836 Macaca mulatta (rhesus monkey) XP_001605059.1 Nasonia vitripennis (wasp) ENSORLP00000016949 Oryzias latipes (japanese killifish) PHUM004975-PA Pediculus humanus (human body louse) PP10656 Pristionchus pacificus (nematode) ENSPTRP00000016660 Pan troglodytes (chimpanzee) XP_796777.2 Strongylocentrotus purpuratus (purple sea urchin) 34034 Trichoplax adhaerens (metazoa) XP_970417.2 Tribolium castaneum (red flour beetle) ENSTNIP00000008616 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000010608 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000042576 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV10111 LH21774 ISCW024238 ISCW014535 ISCW014349 ISCW014149 ISCW010399 ISCW009053 ISCW007794 ISCW005148 ISCW001073 ISCW000257 FBgn0235641 FBgn0220429 FBgn0208855 FBgn0194596 FBgn0173300 FBgn0077508 FBgn0156155 FBgn0133284 FBgn0118444 FBgn0117049 FBgn0091428 CPIJ005595 BGIBMGA004655 ACYPI008065 ACYPI004258 GB12198 AGAP009176 AAEL001194 PB22802 PHUM565830 GLEAN_11522
Stocks & Reagents
Stocks Listed in FlyBase ( 10 )
Bloomington	28930 y1 v1; P{TRiP.HM05141}attP2 35775 y1 sc* v1; P{TRiP.HMS01524}attP2 13255 w1118; P{SUPor-P}CG3523KG03696/CyO, P{sevRas1.V12}FK1
Harvard	- P{XP}CG3523d02216 - P{XP}CG3523d06961
Kyoto	125665 w1118; P{RS5}CG35235-HA-2771 103797 w*; P{GawB}CG3523NP0870 / CyO 113610 w*; P{GawB}CG3523NP5166 / CyO, P{UAS-lacZ.UW14}UW14
VDRC	v108339 P{KK107330}VIE-260B v29349 w1118; P{GD14739}v29349/CyO
Genomic Clones ( 1 )
	BACR48B06 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 118 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH07626 GH17750
Other clones	AF171846
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT26913 GH03692 GH03802 GH05332 GH06839 GH06884 GH06939 GH06984 GH07443 GH07849 GH09486 GH10407 GH12316 GH12648 GH15553 GH15620 GH15635 GH17723 GH17725 GH18043 GH18388 GH18428 GH18441 GH18553 GH19629 GH20635 GH20772 GH20967 GH21222 GH22015 GH22229 GH22808 GH23226 GH24318 GH24695 GH25328 GH26646 GH27617 GM06051 GM07709 GM14149 GM29353 GM30691 HL07376 LP03821 LP04444 LP05916 LP07413 LP07480 LP08572 LP08666 LP09561 LP12942 LP13243 LP14067 LP15773 LP16284 LP21326 LP23476 RH01461 RH02843 RH04107 RH40546 RH45146 RH51806 SD02732 SD03503 SD03843 SD07662 SD09117 SD11242 SD13352 SD15391 SD15888 SD19164 SD21136 SD25661 SD26829 SD27669
Other clones	Dmel_dig_010945_0707_2593 Dmel_neb_009438_0882_3462 Dmel_neb_009981_0872_2290 Dmel_neb_010546_0570_1156 Dmel_neb_013872_0922_0954 Dmel_neb_015945_0831_0994 EK069031 EK076354 EK089806 EK122625 EK124317 EK140426 EK143606 EK151236 EK163011 EK198120 EK213834 EK264962 EK293549 EN03827 EN07139 EN09044 EN12928 EN13811 EP21452 GH05642 GH07812 GH16931 GH27052 IP04551 IP13236 IP13436 IP13536 UT01836 UT01949
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0027571 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33524
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: BcDNA:GH07626 anon-EST:Posey235 anon-EST:Posey43 (Bayraktaroglu, 2000.11.2) Source for merge of: CG3523 anon-WO0138581.1 (FlyBase, 1996-)
Additional comments	Source for merge of CG3523 anon-WO0138581.1 was sequence comparison (date:051113). (FlyBase, 1996-)
Other Comments
	The gene referred to as "CG3525" in Table 2 of FBrf0201413 should have been referred to as "CG3523". (Firth and Baker, 2009) Identified in an RNAi screen for host factors that alter infection of SL2 cells by M.fortuitum. (Philips et al., 2005)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_134904 NM_001144306 RefSeq (Proteins) • NP_608748 NP_001137778 DDBJ / EMBL / GenBank • AAD38618 AAF51148 ACL82985 AF145643 AF171776 AF171846 AI106701 AI402090 AX153650 BH614987 CZ474170 CZ475452 CZ475453 CZ488273 CZ488274 Entrez Gene - A searchable database of RefSeq genes. • 33524 UniProtKB/TrEMBL • B7Z001 Q7KML1 Q9VQL7
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Beta-ketoacyl synthase (IPR000794) Thioesterase (IPR001031) Acyl transferase domain (IPR001227) Short-chain dehydrogenase/reductase SDR (IPR002198) Acyl carrier protein-like (IPR009081) Alcohol dehydrogenase, C-terminal (IPR013149) Polyketide synthase, KR (IPR013968) Beta-ketoacyl synthase, active site (IPR018201) GroES-like (IPR011032) Beta-ketoacyl synthase, N-terminal (IPR014030) Beta-ketoacyl synthase, C-terminal (IPR014031) Acyl transferase (IPR014043) NAD(P)-binding domain (IPR016040) Acyl transferase/acyl hydrolase/lysophospholipase (IPR016035) Malonyl-CoA ACP transacylase, ACP-binding (IPR016036) Thiolase-like, subgroup (IPR016038) Thiolase-like (IPR016039) Polyketide synthase, enoylreductase (IPR020843) Polyketide synthase/Fatty acid synthase, KR (IPR020842) Phosphopantetheine-binding (IPR006163) Fatty acid synthase, domain 2 (IPR023102)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0027571 DRSC - Results from RNAi screens. • FBgn0027571 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0027571 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3523-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0027571 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33524 InParanoid A subset of ortholog calls from InParanoid. • AAEL001194-PA Aedes aegypti (mosquito) AGAP009176-PA Anopheles gambiae (mosquito) XP_396268.2 Apis mellifera (honey bee) XP_001945190.1 Acyrthosiphon pisum (pea aphid) 108803 Branchiostoma floridae (lancelet) 87410 Branchiostoma floridae (lancelet) XP_001898484.1 Brugia malayi (roundworm nematode) BGIBMGA004655-PA Bombyx mori (silk worm) ENSBTAP00000052914 Bos taurus (bovine) CN12046 Caenorhabditis brenneri (small nematode) CN20040 Caenorhabditis brenneri (small nematode) CBP31596 Caenorhabditis briggsae (nematode) CE42777 Caenorhabditis elegans (worm) ENSCAFP00000009039 Canis familiaris (dog) JA02513 Caenorhabditis japonica (nematode) CPIJ005595 Culex pipens (mosquito) ENSCPOP00000002086 Cavia porcellus (guinea pig) RP37939 Caenorhabditis remanei (nematode) 102987 Capitella spl (polychaete worm) DDB0234163 Dictyostelium discoideum (amoeba) ENSDARP00000090540 Danio rerio (zebra fish) ENSDARP00000090546 Danio rerio (zebra fish) ENSECAP00000017442 Equus caballus (horse) ENSGACP00000002882 Gymnopilus aculeatus (mushroom) ENSGALP00000038133 Gallus gallus (chicken) 99033 Hypsipyla robusta (cedar shoot borer) ENSP00000304592 Homo sapiens (human) ISCW009053-PA Ixodes scapularis (deer tick) 235996 Lottia gigantea (owl limpet) ENSMODP00000004189 Monodelphis domestica (gray opossum) ENSMMUP00000016836 Macaca mulatta (rhesus monkey) XP_001605059.1 Nasonia vitripennis (wasp) ENSORLP00000016949 Oryzias latipes (japanese killifish) PHUM004975-PA Pediculus humanus (human body louse) PP10656 Pristionchus pacificus (nematode) ENSPTRP00000016660 Pan troglodytes (chimpanzee) XP_796777.2 Strongylocentrotus purpuratus (purple sea urchin) 34034 Trichoplax adhaerens (metazoa) XP_970417.2 Tribolium castaneum (red flour beetle) ENSTNIP00000008616 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000010608 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000042576 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33524 modMine - Data generated by the modENCODE project. • FBgn0027571 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV10111 LH21774 ISCW024238 ISCW014535 ISCW014349 ISCW014149 ISCW010399 ISCW009053 ISCW007794 ISCW005148 ISCW001073 ISCW000257 FBgn0235641 FBgn0220429 FBgn0208855 FBgn0194596 FBgn0173300 FBgn0077508 FBgn0156155 FBgn0133284 FBgn0118444 FBgn0117049 FBgn0091428 CPIJ005595 BGIBMGA004655 ACYPI008065 ACYPI004258 GB12198 AGAP009176 AAEL001194 PB22802 PHUM565830 GLEAN_11522
Synonyms & Secondary IDs ( 13 )
Reported As
Symbol Synonym	anon-EST:Posey43   anon-EST:Posey235   anon-WO0138581.1   BcDNA:gh07626 (Michaut et al., 2003) BcDNA:GH07626 (Zinke et al., 2002, Ballard et al., 2010) CG3523 (Beller et al., 2006, Beller et al., 2006, Dionne et al., 2006, Quinones-Coello, 2007, Zhang et al., 2007, Palanker et al., 2009, Teleman et al., 2008, Keleman et al., 2009.8.5, Perkins et al., 2009, Chen et al., 2008, Haussmann et al., 2008, Firth and Baker, 2009, Ni et al., 2011.7.19, Cammarato et al., 2011) dFAS (Porstmann et al., 2008) DM_7295848 (Nordling et al., 2002) FAS (Lim et al., 2011, Okamura et al., 2007, Kunte et al., 2006, Bauer et al., 2009, Birse et al., 2010) fas (Suh et al., 2006) Fatty acid synthase (Rawson, 2003, Seegmiller et al., 2002, Seegmiller et al., 2002)
Name Synonym	fatty acid synthase (Teleman et al., 2008, Kunte et al., 2006, Bauer et al., 2009, Suh et al., 2006) Fatty acid synthetase (Kang et al., 2002, Okamura et al., 2007)
Secondary FlyBase IDs
	FBgn0027682 FBgn0027719 FBgn0044793
References ( 50 )
Generate a list of	All references relating to this gene ( 50 )
List References by type	Research paper  ( 22 ) Supplementary material  ( 11 ) Review  ( 1 ) Erratum  ( 1 ) Personal communication to FlyBase  ( 7 ) FlyBase analysis  ( 3 ) Computer file  ( 3 ) Automatic genome annotation  ( 1 ) Patent  ( 1 )
Recent research papers ( 3 )
	Lim et al., 2011, Genes Dev. 25(2): 189--200 Phospholipid homeostasis regulates lipid metabolism and cardiac function through SREBP signaling in Drosophila. [FBrf0212844] Ballard et al., 2010, Dev. Biol. 337(2): 375--385 Gbb/BMP signaling is required to maintain energy homeostasis in Drosophila. [FBrf0209816] Birse et al., 2010, Cell Metab. 12(5): 533--544 High-fat-diet-induced obesity and heart dysfunction are regulated by the TOR pathway in Drosophila. [FBrf0212220] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...