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Gene Dmel\CG6191

General Information
Symbol	Dmel\CG6191	Species	D. melanogaster
Name		Annotation symbol	CG6191
Feature type	protein_coding_gene	FlyBase ID	FBgn0027581
Gene Model Status	Current	Stock availability	10 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	50B3-50B4	Sequence location	2R:9,467,818..9,480,844 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG6191 (FBgn0027581). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: cyclin-dependent protein serine/threonine kinase regulator activity. There is experimental evidence that it is involved in the biological process: phagocytosis, engulfment. 10 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Cdk5/c-Abl linker protein Cables; Cyclin, N-terminal; Cyclin-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: adult eye, larval Malpighian tubules. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, adult Malpighian tubules, adult heart, larval/adult fat body, adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1625281_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG6191. Gene sequence location is 2R:9467818..9480844.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 50B3-50B4   Limits computationally determined from genome sequence between P{lacW}drkk13809&P{EP}mip120EP606 and P{lacW}l(2)03105k16702&P{lacW}fl(2)dk16105
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG6191 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Stop-codon suppression (UAG) postulated; FBrf0216884 gene_with_stop_codon_read_through ; SO:0000697 Gene model reviewed during 5.44 Low-frequency RNA-Seq exon junction(s) not annotated. Gene model reviewed during 5.50 5' UTR contains an ORF described as a putative conserved uORF (FBrf0204849); potential peptide 21aa in length.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG6191-RA FBtr0087678  NM_137046   3439   717 CG6191-RB FBtr0330617  NM_001274028   3745   728 CG6191-RC FBtr0330618  NM_001274029   3439   746
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG6191-PA   FBpp0086798   79.3   717   10.26     NP_610890   AAF58349 CG6191-PB   FBpp0303467   80.6   728   10.34     NP_001260957   AGB93489 CG6191-PC   FBpp0303468   82.5   746   10.33     NP_001260958   AGB93490
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Cdk5/c-Abl linker protein Cables (IPR012388) Cyclin, N-terminal (IPR006671) Cyclin-like (IPR013763)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA695214   AA695692   AA698042   AA950193   AE013599 AAF58349   AF145634 AAD38609   AE013599 AGB93489   AE013599 AGB93490   AI106930   AI402040   AI406174   AI517829   AI532891   BG633589   BI167398   BI228132   BI371630   BT133388   CA805124   CO152804   CO154278   CO155026   CO178209   CO266922   CO272369   CO307964   CO313230   CO318999   CO320745   CO323013   CO327178   CO338339   CW848204   CZ473411   CZ478752   CZ481534   CZ482948   EC078455   EC199125   EC205090   EC218572   EC227372   EC237142   EC239221   EC243728   EC263490   EC265638   EC267369   FF579534   GH741403   GH747266   GH765130   GH765790   GH768258   GH769354   GH769427   GH769617   GH769644   GH769973   GH779312   GH779585
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	A1Z9G1 Q9Y138
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: adult eye, larval Malpighian tubules. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, adult Malpighian tubules, adult heart, larval/adult fat body, adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    142.95 Larval Midgut    115.9 Larval Hindgut    160.1 Larval Malpighian Tubules    1359.8 Larval Fat Body    243.1 Larval Salivary Gland    71.2 Larval Trachea    253.15 Larval Carcass    125.225 Adult Head    195.3 Adult Eye    599.3 Adult Brain    489.1 Adult Thoracic-Abdominal Ganglion    392.9 Adult Crop    136.9 Adult Midgut    249.6 Adult Hindgut    117.3 Adult Malpighian Tubules    358.3 Adult Fat Body    106.6 Adult Salivary Gland    138.9 Adult Heart    201.35 Adult VirginFemale Spermatheca    109.6 Adult InseminatedFemale Spermatheca    100 Adult Ovary    166.2 Adult Testis    39.3 Adult Male Accessory Gland    236.5 Adult Carcass    124.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    142.95 Larval Midgut    115.9 Larval Hindgut    160.1 Larval Malpighian Tubules  (1359.8) Larval Fat Body    243.1 Larval Salivary Gland    71.2 Larval Trachea    253.15 Larval Carcass    125.225 Adult Head    195.3 Adult Eye  (599.3) Adult Brain    489.1 Adult Thoracic-Abdominal Ganglion    392.9 Adult Crop    136.9 Adult Midgut    249.6 Adult Hindgut    117.3 Adult Malpighian Tubules    358.3 Adult Fat Body    106.6 Adult Salivary Gland    138.9 Adult Heart    201.35 Adult VirginFemale Spermatheca    109.6 Adult InseminatedFemale Spermatheca    100 Adult Ovary    166.2 Adult Testis    39.3 Adult Male Accessory Gland    236.5 Adult Carcass    124.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    142.95 Larval Midgut    115.9 Larval Hindgut    160.1 Larval Malpighian Tubules  (1359.8) Larval Fat Body    243.1 Larval Salivary Gland    71.2 Larval Trachea    253.15 Larval Carcass    125.225 Adult Head    195.3 Adult Eye    599.3 Adult Brain    489.1 Adult Thoracic-Abdominal Ganglion    392.9 Adult Crop    136.9 Adult Midgut    249.6 Adult Hindgut    117.3 Adult Malpighian Tubules    358.3 Adult Fat Body    106.6 Adult Salivary Gland    138.9 Adult Heart    201.35 Adult VirginFemale Spermatheca    109.6 Adult InseminatedFemale Spermatheca    100 Adult Ovary    166.2 Adult Testis    39.3 Adult Male Accessory Gland    236.5 Adult Carcass    124.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    142.95 Larval Midgut    115.9 Larval Hindgut    160.1 Larval Malpighian Tubules    1359.8 Larval Fat Body    243.1 Larval Salivary Gland    71.2 Larval Trachea    253.15 Larval Carcass    125.225 Adult Head    195.3 Adult Eye    599.3 Adult Brain    489.1 Adult Thoracic-Abdominal Ganglion    392.9 Adult Crop    136.9 Adult Midgut    249.6 Adult Hindgut    117.3 Adult Malpighian Tubules    358.3 Adult Fat Body    106.6 Adult Salivary Gland    138.9 Adult Heart    201.35 Adult VirginFemale Spermatheca    109.6 Adult InseminatedFemale Spermatheca    100 Adult Ovary    166.2 Adult Testis    39.3 Adult Male Accessory Gland    236.5 Adult Carcass    124.5 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    142.95 Larval Midgut    115.9 Larval Hindgut    160.1 Larval Malpighian Tubules    1359.8 Larval Fat Body    243.1 Larval Salivary Gland    71.2 Larval Trachea    253.15 Larval Carcass    125.225 Adult Head    195.3 Adult Eye    599.3 Adult Brain    489.1 Adult Thoracic-Abdominal Ganglion    392.9 Adult Crop    136.9 Adult Midgut    249.6 Adult Hindgut    117.3 Adult Malpighian Tubules    358.3 Adult Fat Body    106.6 Adult Salivary Gland    138.9 Adult Heart    201.35 Adult VirginFemale Spermatheca    109.6 Adult InseminatedFemale Spermatheca    100 Adult Ovary    166.2 Adult Testis    39.3 Adult Male Accessory Gland    236.5 Adult Carcass    124.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    142.95 Larval Midgut    115.9 Larval Hindgut    160.1 Larval Malpighian Tubules  (1359.8) Larval Fat Body    243.1 Larval Salivary Gland    71.2 Larval Trachea    253.15 Larval Carcass    125.225 Adult Head    195.3 Adult Eye  599.3 Adult Brain    489.1 Adult Thoracic-Abdominal Ganglion    392.9 Adult Crop    136.9 Adult Midgut    249.6 Adult Hindgut    117.3 Adult Malpighian Tubules    358.3 Adult Fat Body    106.6 Adult Salivary Gland    138.9 Adult Heart    201.35 Adult VirginFemale Spermatheca    109.6 Adult InseminatedFemale Spermatheca    100 Adult Ovary    166.2 Adult Testis    39.3 Adult Male Accessory Gland    236.5 Adult Carcass    124.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    142.95 Larval Midgut    115.9 Larval Hindgut    160.1 Larval Malpighian Tubules  1359.8 Larval Fat Body    243.1 Larval Salivary Gland    71.2 Larval Trachea    253.15 Larval Carcass    125.225 Adult Head    195.3 Adult Eye    599.3 Adult Brain    489.1 Adult Thoracic-Abdominal Ganglion    392.9 Adult Crop    136.9 Adult Midgut    249.6 Adult Hindgut    117.3 Adult Malpighian Tubules    358.3 Adult Fat Body    106.6 Adult Salivary Gland    138.9 Adult Heart    201.35 Adult VirginFemale Spermatheca    109.6 Adult InseminatedFemale Spermatheca    100 Adult Ovary    166.2 Adult Testis    39.3 Adult Male Accessory Gland    236.5 Adult Carcass    124.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    142.95 Larval Midgut    115.9 Larval Hindgut    160.1 Larval Malpighian Tubules    1359.8 Larval Fat Body    243.1 Larval Salivary Gland    71.2 Larval Trachea    253.15 Larval Carcass    125.225 Adult Head    195.3 Adult Eye    599.3 Adult Brain    489.1 Adult Thoracic-Abdominal Ganglion    392.9 Adult Crop    136.9 Adult Midgut    249.6 Adult Hindgut    117.3 Adult Malpighian Tubules    358.3 Adult Fat Body    106.6 Adult Salivary Gland    138.9 Adult Heart    201.35 Adult VirginFemale Spermatheca    109.6 Adult InseminatedFemale Spermatheca    100 Adult Ovary    166.2 Adult Testis    39.3 Adult Male Accessory Gland    236.5 Adult Carcass    124.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    195.3   NA  Eye    599.3   NA  Brain    489.1   142.95  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    392.9   NA  Crop    136.9   115.9  Midgut    249.6   160.1  Hindgut    117.3   1359.8  Malpighian Tubules    358.3   243.1  Fat Body    106.6   71.2  Salivary Gland    138.9   NA  Heart    201.35   253.15  Trachea    NA   NA  VirginFemale Spermatheca    109.6   NA  InseminatedFemale Spermatheca    100   NA  Ovary    166.2   NA  Testis    39.3   NA  Male Accessory Gland    236.5   125.225  Carcass    124.5 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    15 central nervous system, pupae P8    25 head, virgin 1-day female    22 head, virgin 4-day female    24 head, virgin 20-day female    21 head, mated 1-day female    22 head, mated 4-day female    17 head, mated 20-day female    20 head, mated 1-day male    37 head, mated 4-day male    29 head, mated 20-day male    32 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    17 digestive system, larvae L3 wandering    34 digestive system, 1-day adult    25 digestive system, 4-day adult    21 digestive system, 20-day adult    28 fat body, larvae L3 wandering    16 fat body, white prepupae    9 fat body, pupae P8    18 carcass, larvae L3 wandering    14 carcass, 1-day adult    13 carcass, 4-day adult    11 carcass, 20-day adult    12 ovary, virgin 4-day female    24 ovary, mated 4-day female    22 testis, mated 4-day male    4 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    15 central nervous system, pupae P8    25 head, virgin 1-day female    22 head, virgin 4-day female    24 head, virgin 20-day female    21 head, mated 1-day female    22 head, mated 4-day female    17 head, mated 20-day female    20 head, mated 1-day male  (37) head, mated 4-day male  (29) head, mated 20-day male  (32) salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    17 digestive system, larvae L3 wandering  (34) digestive system, 1-day adult    25 digestive system, 4-day adult    21 digestive system, 20-day adult  (28) fat body, larvae L3 wandering    16 fat body, white prepupae    9 fat body, pupae P8    18 carcass, larvae L3 wandering    14 carcass, 1-day adult    13 carcass, 4-day adult    11 carcass, 20-day adult    12 ovary, virgin 4-day female    24 ovary, mated 4-day female    22 testis, mated 4-day male    4 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    15 central nervous system, pupae P8    25 head, virgin 1-day female    22 head, virgin 4-day female    24 head, virgin 20-day female    21 head, mated 1-day female    22 head, mated 4-day female    17 head, mated 20-day female    20 head, mated 1-day male    37 head, mated 4-day male    29 head, mated 20-day male    32 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    17 digestive system, larvae L3 wandering    34 digestive system, 1-day adult    25 digestive system, 4-day adult    21 digestive system, 20-day adult    28 fat body, larvae L3 wandering    16 fat body, white prepupae    9 fat body, pupae P8    18 carcass, larvae L3 wandering    14 carcass, 1-day adult    13 carcass, 4-day adult    11 carcass, 20-day adult    12 ovary, virgin 4-day female    24 ovary, mated 4-day female    22 testis, mated 4-day male    4 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    15 central nervous system, pupae P8    25 head, virgin 1-day female    22 head, virgin 4-day female    24 head, virgin 20-day female    21 head, mated 1-day female    22 head, mated 4-day female    17 head, mated 20-day female    20 head, mated 1-day male    37 head, mated 4-day male    29 head, mated 20-day male    32 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    17 digestive system, larvae L3 wandering    34 digestive system, 1-day adult    25 digestive system, 4-day adult    21 digestive system, 20-day adult    28 fat body, larvae L3 wandering    16 fat body, white prepupae    9 fat body, pupae P8    18 carcass, larvae L3 wandering    14 carcass, 1-day adult    13 carcass, 4-day adult    11 carcass, 20-day adult    12 ovary, virgin 4-day female    24 ovary, mated 4-day female    22 testis, mated 4-day male    4 accessory gland, mated 4-day male    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    15 central nervous system, pupae P8    25 head, virgin 1-day female    22 head, virgin 4-day female    24 head, virgin 20-day female    21 head, mated 1-day female    22 head, mated 4-day female    17 head, mated 20-day female    20 head, mated 1-day male    37 head, mated 4-day male    29 head, mated 20-day male    32 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    17 digestive system, larvae L3 wandering    34 digestive system, 1-day adult    25 digestive system, 4-day adult    21 digestive system, 20-day adult    28 fat body, larvae L3 wandering    16 fat body, white prepupae    9 fat body, pupae P8    18 carcass, larvae L3 wandering    14 carcass, 1-day adult    13 carcass, 4-day adult    11 carcass, 20-day adult    12 ovary, virgin 4-day female    24 ovary, mated 4-day female    22 testis, mated 4-day male    4 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    15 central nervous system, pupae P8    25 head, virgin 1-day female    22 head, virgin 4-day female    24 head, virgin 20-day female    21 head, mated 1-day female    22 head, mated 4-day female    17 head, mated 20-day female    20 head, mated 1-day male  (37) head, mated 4-day male  29 head, mated 20-day male  32 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    17 digestive system, larvae L3 wandering  (34) digestive system, 1-day adult    25 digestive system, 4-day adult    21 digestive system, 20-day adult  28 fat body, larvae L3 wandering    16 fat body, white prepupae    9 fat body, pupae P8    18 carcass, larvae L3 wandering    14 carcass, 1-day adult    13 carcass, 4-day adult    11 carcass, 20-day adult    12 ovary, virgin 4-day female    24 ovary, mated 4-day female    22 testis, mated 4-day male    4 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    15 central nervous system, pupae P8    25 head, virgin 1-day female    22 head, virgin 4-day female    24 head, virgin 20-day female    21 head, mated 1-day female    22 head, mated 4-day female    17 head, mated 20-day female    20 head, mated 1-day male    37 head, mated 4-day male    29 head, mated 20-day male    32 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    17 digestive system, larvae L3 wandering    34 digestive system, 1-day adult    25 digestive system, 4-day adult    21 digestive system, 20-day adult    28 fat body, larvae L3 wandering    16 fat body, white prepupae    9 fat body, pupae P8    18 carcass, larvae L3 wandering    14 carcass, 1-day adult    13 carcass, 4-day adult    11 carcass, 20-day adult    12 ovary, virgin 4-day female    24 ovary, mated 4-day female    22 testis, mated 4-day male    4 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    15 central nervous system, pupae P8    25 head, virgin 1-day female    22 head, virgin 4-day female    24 head, virgin 20-day female    21 head, mated 1-day female    22 head, mated 4-day female    17 head, mated 20-day female    20 head, mated 1-day male    37 head, mated 4-day male    29 head, mated 20-day male    32 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    17 digestive system, larvae L3 wandering    34 digestive system, 1-day adult    25 digestive system, 4-day adult    21 digestive system, 20-day adult    28 fat body, larvae L3 wandering    16 fat body, white prepupae    9 fat body, pupae P8    18 carcass, larvae L3 wandering    14 carcass, 1-day adult    13 carcass, 4-day adult    11 carcass, 20-day adult    12 ovary, virgin 4-day female    24 ovary, mated 4-day female    22 testis, mated 4-day male    4 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    28 embryo 02-04hr    17 embryo 04-06hr    13 embryo 06-08hr    13 embryo 08-10hr    18 embryo 10-12hr    23 embryo 12-14hr    22 embryo 14-16hr    23 embryo 16-18hr    21 embryo 18-20hr    22 embryo 20-22hr    29 embryo 22-24hr    30 larva L1    21 larva L2    14 larva L3 12hr old    13 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    30 white prepupae new    26 white prepupae 12hr    59 white prepupae 24hr    28 pupae 2d postWPP    29 pupae 3d postWPP    22 pupae 4d postWPP    23 adult male 01day    20 adult male 05day    21 adult male 30day    23 adult female 01day    25 adult female 05day    22 adult female 30day    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (28) embryo 02-04hr    17 embryo 04-06hr    13 embryo 06-08hr    13 embryo 08-10hr    18 embryo 10-12hr    23 embryo 12-14hr    22 embryo 14-16hr    23 embryo 16-18hr    21 embryo 18-20hr    22 embryo 20-22hr  (29) embryo 22-24hr  (30) larva L1    21 larva L2    14 larva L3 12hr old    13 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9  (30) white prepupae new  26 white prepupae 12hr  (59) white prepupae 24hr  (28) pupae 2d postWPP  (29) pupae 3d postWPP    22 pupae 4d postWPP    23 adult male 01day    20 adult male 05day    21 adult male 30day    23 adult female 01day    25 adult female 05day    22 adult female 30day    23 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    28 embryo 02-04hr    17 embryo 04-06hr    13 embryo 06-08hr    13 embryo 08-10hr    18 embryo 10-12hr    23 embryo 12-14hr    22 embryo 14-16hr    23 embryo 16-18hr    21 embryo 18-20hr    22 embryo 20-22hr    29 embryo 22-24hr    30 larva L1    21 larva L2    14 larva L3 12hr old    13 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    30 white prepupae new    26 white prepupae 12hr    59 white prepupae 24hr    28 pupae 2d postWPP    29 pupae 3d postWPP    22 pupae 4d postWPP    23 adult male 01day    20 adult male 05day    21 adult male 30day    23 adult female 01day    25 adult female 05day    22 adult female 30day    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    28 embryo 02-04hr    17 embryo 04-06hr    13 embryo 06-08hr    13 embryo 08-10hr    18 embryo 10-12hr    23 embryo 12-14hr    22 embryo 14-16hr    23 embryo 16-18hr    21 embryo 18-20hr    22 embryo 20-22hr    29 embryo 22-24hr    30 larva L1    21 larva L2    14 larva L3 12hr old    13 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    30 white prepupae new    26 white prepupae 12hr    59 white prepupae 24hr    28 pupae 2d postWPP    29 pupae 3d postWPP    22 pupae 4d postWPP    23 adult male 01day    20 adult male 05day    21 adult male 30day    23 adult female 01day    25 adult female 05day    22 adult female 30day    23 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    28 embryo 02-04hr    17 embryo 04-06hr    13 embryo 06-08hr    13 embryo 08-10hr    18 embryo 10-12hr    23 embryo 12-14hr    22 embryo 14-16hr    23 embryo 16-18hr    21 embryo 18-20hr    22 embryo 20-22hr    29 embryo 22-24hr    30 larva L1    21 larva L2    14 larva L3 12hr old    13 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    30 white prepupae new    26 white prepupae 12hr    59 white prepupae 24hr    28 pupae 2d postWPP    29 pupae 3d postWPP    22 pupae 4d postWPP    23 adult male 01day    20 adult male 05day    21 adult male 30day    23 adult female 01day    25 adult female 05day    22 adult female 30day    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  28 embryo 02-04hr    17 embryo 04-06hr    13 embryo 06-08hr    13 embryo 08-10hr    18 embryo 10-12hr    23 embryo 12-14hr    22 embryo 14-16hr    23 embryo 16-18hr    21 embryo 18-20hr    22 embryo 20-22hr  29 embryo 22-24hr  30 larva L1    21 larva L2    14 larva L3 12hr old    13 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9  30 white prepupae new  26 white prepupae 12hr  (59) white prepupae 24hr  28 pupae 2d postWPP  29 pupae 3d postWPP    22 pupae 4d postWPP    23 adult male 01day    20 adult male 05day    21 adult male 30day    23 adult female 01day    25 adult female 05day    22 adult female 30day    23 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    28 embryo 02-04hr    17 embryo 04-06hr    13 embryo 06-08hr    13 embryo 08-10hr    18 embryo 10-12hr    23 embryo 12-14hr    22 embryo 14-16hr    23 embryo 16-18hr    21 embryo 18-20hr    22 embryo 20-22hr    29 embryo 22-24hr    30 larva L1    21 larva L2    14 larva L3 12hr old    13 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    30 white prepupae new    26 white prepupae 12hr    59 white prepupae 24hr    28 pupae 2d postWPP    29 pupae 3d postWPP    22 pupae 4d postWPP    23 adult male 01day    20 adult male 05day    21 adult male 30day    23 adult female 01day    25 adult female 05day    22 adult female 30day    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    28 embryo 02-04hr    17 embryo 04-06hr    13 embryo 06-08hr    13 embryo 08-10hr    18 embryo 10-12hr    23 embryo 12-14hr    22 embryo 14-16hr    23 embryo 16-18hr    21 embryo 18-20hr    22 embryo 20-22hr    29 embryo 22-24hr    30 larva L1    21 larva L2    14 larva L3 12hr old    13 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    30 white prepupae new    26 white prepupae 12hr    59 white prepupae 24hr    28 pupae 2d postWPP    29 pupae 3d postWPP    22 pupae 4d postWPP    23 adult male 01day    20 adult male 05day    21 adult male 30day    23 adult female 01day    25 adult female 05day    22 adult female 30day    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    15 Schneider line 2 Sg4    8 embryonic 1182-4H    25 embryonic GM2    9 embryonic Kc167    22 embryonic S1    12 embryonic S3    22 leg disc CME L1    6 wing disc CME-W2    8 wing disc ML-DmD8    8 wing disc ML-DmD9    9 wing disc ML-DmD16-c3    9 wing disc ML-DmD21    12 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    16 eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5    6 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    15 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    18 ovary fGS/OSS    53 ovary OSC    5 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    15 Schneider line 2 Sg4    8 embryonic 1182-4H    25 embryonic GM2    9 embryonic Kc167    22 embryonic S1    12 embryonic S3    22 leg disc CME L1    6 wing disc CME-W2    8 wing disc ML-DmD8    8 wing disc ML-DmD9    9 wing disc ML-DmD16-c3    9 wing disc ML-DmD21    12 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    16 eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5    6 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    15 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    18 ovary fGS/OSS  (53) ovary OSC    5 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    15 Schneider line 2 Sg4    8 embryonic 1182-4H    25 embryonic GM2    9 embryonic Kc167    22 embryonic S1    12 embryonic S3    22 leg disc CME L1    6 wing disc CME-W2    8 wing disc ML-DmD8    8 wing disc ML-DmD9    9 wing disc ML-DmD16-c3    9 wing disc ML-DmD21    12 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    16 eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5    6 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    15 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    18 ovary fGS/OSS    53 ovary OSC    5 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    15 Schneider line 2 Sg4    8 embryonic 1182-4H    25 embryonic GM2    9 embryonic Kc167    22 embryonic S1    12 embryonic S3    22 leg disc CME L1    6 wing disc CME-W2    8 wing disc ML-DmD8    8 wing disc ML-DmD9    9 wing disc ML-DmD16-c3    9 wing disc ML-DmD21    12 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    16 eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5    6 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    15 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    18 ovary fGS/OSS    53 ovary OSC    5 ovary OSS    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    15 Schneider line 2 Sg4    8 embryonic 1182-4H    25 embryonic GM2    9 embryonic Kc167    22 embryonic S1    12 embryonic S3    22 leg disc CME L1    6 wing disc CME-W2    8 wing disc ML-DmD8    8 wing disc ML-DmD9    9 wing disc ML-DmD16-c3    9 wing disc ML-DmD21    12 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    16 eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5    6 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    15 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    18 ovary fGS/OSS    53 ovary OSC    5 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    15 Schneider line 2 Sg4    8 embryonic 1182-4H    25 embryonic GM2    9 embryonic Kc167    22 embryonic S1    12 embryonic S3    22 leg disc CME L1    6 wing disc CME-W2    8 wing disc ML-DmD8    8 wing disc ML-DmD9    9 wing disc ML-DmD16-c3    9 wing disc ML-DmD21    12 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    16 eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5    6 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    15 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    18 ovary fGS/OSS  (53) ovary OSC    5 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    15 Schneider line 2 Sg4    8 embryonic 1182-4H    25 embryonic GM2    9 embryonic Kc167    22 embryonic S1    12 embryonic S3    22 leg disc CME L1    6 wing disc CME-W2    8 wing disc ML-DmD8    8 wing disc ML-DmD9    9 wing disc ML-DmD16-c3    9 wing disc ML-DmD21    12 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    16 eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5    6 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    15 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    18 ovary fGS/OSS    53 ovary OSC    5 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    15 Schneider line 2 Sg4    8 embryonic 1182-4H    25 embryonic GM2    9 embryonic Kc167    22 embryonic S1    12 embryonic S3    22 leg disc CME L1    6 wing disc CME-W2    8 wing disc ML-DmD8    8 wing disc ML-DmD9    9 wing disc ML-DmD16-c3    9 wing disc ML-DmD21    12 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    16 eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5    6 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    15 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    18 ovary fGS/OSS    53 ovary OSC    5 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    22 cold shock, 4-day adult    17 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    17 Cadmium 100 mM 48 hrs, 4-day adult    26 Copper 0.5 mM 12 hrs, larvae L3    16 Copper 15 mM 48 hrs, 4-day adult    16 Zinc 5 mM 12 hrs, larvae L3    16 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    38 Ethanol 5% 3 hrs, larvae L3    14 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    17 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    28 Caffeine 25 mg/ml 48 hrs, 4-day adult    19 Paraquat 5 mM 48 hrs, 4-day adult    27 Paraquat 10 mM 48 hrs, 4-day adult    32 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    22 cold shock, 4-day adult    17 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    17 Cadmium 100 mM 48 hrs, 4-day adult  26 Copper 0.5 mM 12 hrs, larvae L3    16 Copper 15 mM 48 hrs, 4-day adult    16 Zinc 5 mM 12 hrs, larvae L3    16 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3  (38) Ethanol 5% 3 hrs, larvae L3    14 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    17 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (28) Caffeine 25 mg/ml 48 hrs, 4-day adult    19 Paraquat 5 mM 48 hrs, 4-day adult  (27) Paraquat 10 mM 48 hrs, 4-day adult  (32) Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    22 cold shock, 4-day adult    17 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    17 Cadmium 100 mM 48 hrs, 4-day adult    26 Copper 0.5 mM 12 hrs, larvae L3    16 Copper 15 mM 48 hrs, 4-day adult    16 Zinc 5 mM 12 hrs, larvae L3    16 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    38 Ethanol 5% 3 hrs, larvae L3    14 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    17 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    28 Caffeine 25 mg/ml 48 hrs, 4-day adult    19 Paraquat 5 mM 48 hrs, 4-day adult    27 Paraquat 10 mM 48 hrs, 4-day adult    32 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    22 cold shock, 4-day adult    17 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    17 Cadmium 100 mM 48 hrs, 4-day adult    26 Copper 0.5 mM 12 hrs, larvae L3    16 Copper 15 mM 48 hrs, 4-day adult    16 Zinc 5 mM 12 hrs, larvae L3    16 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    38 Ethanol 5% 3 hrs, larvae L3    14 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    17 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    28 Caffeine 25 mg/ml 48 hrs, 4-day adult    19 Paraquat 5 mM 48 hrs, 4-day adult    27 Paraquat 10 mM 48 hrs, 4-day adult    32 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    22 cold shock, 4-day adult    17 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    17 Cadmium 100 mM 48 hrs, 4-day adult    26 Copper 0.5 mM 12 hrs, larvae L3    16 Copper 15 mM 48 hrs, 4-day adult    16 Zinc 5 mM 12 hrs, larvae L3    16 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    38 Ethanol 5% 3 hrs, larvae L3    14 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    17 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    28 Caffeine 25 mg/ml 48 hrs, 4-day adult    19 Paraquat 5 mM 48 hrs, 4-day adult    27 Paraquat 10 mM 48 hrs, 4-day adult    32 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    22 cold shock, 4-day adult    17 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    17 Cadmium 100 mM 48 hrs, 4-day adult  26 Copper 0.5 mM 12 hrs, larvae L3    16 Copper 15 mM 48 hrs, 4-day adult    16 Zinc 5 mM 12 hrs, larvae L3    16 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3  (38) Ethanol 5% 3 hrs, larvae L3    14 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    17 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  28 Caffeine 25 mg/ml 48 hrs, 4-day adult    19 Paraquat 5 mM 48 hrs, 4-day adult  27 Paraquat 10 mM 48 hrs, 4-day adult  32 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    22 cold shock, 4-day adult    17 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    17 Cadmium 100 mM 48 hrs, 4-day adult    26 Copper 0.5 mM 12 hrs, larvae L3    16 Copper 15 mM 48 hrs, 4-day adult    16 Zinc 5 mM 12 hrs, larvae L3    16 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    38 Ethanol 5% 3 hrs, larvae L3    14 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    17 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    28 Caffeine 25 mg/ml 48 hrs, 4-day adult    19 Paraquat 5 mM 48 hrs, 4-day adult    27 Paraquat 10 mM 48 hrs, 4-day adult    32 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    22 cold shock, 4-day adult    17 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    17 Cadmium 100 mM 48 hrs, 4-day adult    26 Copper 0.5 mM 12 hrs, larvae L3    16 Copper 15 mM 48 hrs, 4-day adult    16 Zinc 5 mM 12 hrs, larvae L3    16 Zinc 4.5 mM 48 hrs, 4-day adult    12 Ethanol 2.5% 3 hrs, larvae L3    38 Ethanol 5% 3 hrs, larvae L3    14 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    17 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    28 Caffeine 25 mg/ml 48 hrs, 4-day adult    19 Paraquat 5 mM 48 hrs, 4-day adult    27 Paraquat 10 mM 48 hrs, 4-day adult    32 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_27 mE1_20_mRNA_expression_cluster_09
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0027581 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6191-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable CG6191EY12761 Sterility Allele fertile CG6191EY12761 Phenotype manifest in Allele
Classical Alleles ( 9 )
For All Classical Alleles Show
Allele of CG6191 Class Mutagen Stocks Known lesion CG61915-HA-1196 1 -- CG6191CB-5484-3 1 -- CG6191d03529 P-element activity 1 -- CG6191e00920 piggyBac transposase 1 -- CG6191e03779 piggyBac transposase 1 -- CG6191EY12761 P-element activity 1 -- CG6191f00477 piggyBac transposase 1 -- CG6191NP3553 1 -- CG6191NP7023 1 --
Alleles Carried on Transgenic Constructs ( 1 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG6191 Class Mutagen Stocks Known lesion CG6191KK109367 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD6583} NA P{KK109367} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}EP2007 NA P{EPgy2}CG6191EY12761 NA P{XP}CG6191d03529 NA miscellaneous insertions P{RS3}CG6191CB-5484-3 NA P{RS5}CG61915-HA-1196 NA PBac{RB}CG6191e00920 NA PBac{RB}CG6191e03779 NA PBac{WH}CG6191f00477 NA insertion of enhancer trap P{lacW}l(2)SH0237SH0237 No insertion of enhancer trap binary system P{GawB}CG6191NP3553 No P{GawB}CG6191NP7023 No
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
phagocytosis, engulfment inferred from mutant phenotype (Stroschein-Stevenson et al., 2006)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
cyclin-dependent protein serine/threonine kinase regulator activity inferred from electronic annotation with InterPro:IPR012388 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
regulation of cell cycle inferred from electronic annotation with InterPro:IPR012388 (FlyBase Curators et al., 2004-) regulation of cell division inferred from electronic annotation with InterPro:IPR012388 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	gene_with_stop_codon_read_through (Jungreis et al., 2011) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG6191 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 62268 DroID - A comprehensive database of gene and protein interactions. • FBgn0027581 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36513 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • A1Z9G1
Orthologs
OrthoDB Orthologs (47) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG69S6S6 Dipteran inclusive ortholog search EOG6FFD98 Insect inclusive ortholog search EOG6JWT8S Arthropod inclusive ortholog search EOG68932S Metazoa inclusive ortholog search EOG6SNDG9
Orthologs in Drosophila Species (EOG69S6S6)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\CG6191     Drosophila simulans   Dsim\GD25748 Y   Drosophila sechellia   Dsec\GM20262 Y   Drosophila erecta   Dere\GG22478 Y   Drosophila yakuba   Dyak\GE13347 Y   Drosophila ananassae   Dana\GF11169 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA19426 Y   Drosophila persimilis   Dper\GL17005 Y   Drosophila willistoni   Dwil\GK15605 Y   Drosophila virilis   Dvir\GJ21810 Y   Drosophila mojavensis   Dmoj\GI18784 Y   Drosophila grimshawi   Dgri\GH20067 Y
Orthologs in non-Drosophila Dipterans (EOG6FFD98)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL005863   Anopheles gambiae Malaria mosquito  Agam\AGAP010843   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ019833   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ001162
Orthologs in non-Dipteran Insects (EOG6JWT8S)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB50857   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG003758   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH15005   Atta cephalotes Leafcutter ant  Acep\ACEP17985   Camponotus floridanus Florida carpenter ant  Cflo\CFLO20072   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL15187   Linepithema humile Argentine ant  Lhum\LH19595   Pogonomyrmex barbatus Red harvester ant  Pbar\PB24368   Acyrthosiphon pisum Pea aphid  Apim\ACYPI002029   Bombyx mori Silkmoth  Bmor\BGIBMGA002977   Pediculus humanus Human body louse  Phum\PHUM586210   Tribolium castaneum Red flour beetle  Tcas\TC013369
Orthologs in non-Insect Arthropods (EOG68932S)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_53154   Ixodes scapularis Deer tick  Isca\ISCW019385
Orthologs in non-Arthropod Metazoa (EOG6SNDG9)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\Y71F9B.6   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_000952gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_023228gn   Danio rerio Zebrafish  Drer\ENSDARG00000062044   Danio rerio Zebrafish  Drer\si:dkey-202m22.8   Danio rerio Zebrafish  Drer\OTTDARG00000030589   Xenopus tropicalis Western clawed frog  Xtro\cables1   Xenopus tropicalis Western clawed frog  Xtro\cables2   Gallus gallus Domestic chicken  Ggal\CABLES1   Gallus gallus Domestic chicken  Ggal\CABLES2   Mus musculus House mouse  Mmus\Gm6190   Mus musculus House mouse  Mmus\Cables2   Mus musculus House mouse  Mmus\Cables1   Rattus norvegicus Norway rat  Rnor\Cables2   Rattus norvegicus Norway rat  Rnor\Cables1   Homo sapiens Human  Hsap\CABLES2   Homo sapiens Human  Hsap\CABL1
Human Orthologs (2)
Gene OMIM HGNC Hsap\CABLES2     Hsap\CABL1
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD25748 Drosophila sechellia Dsec\GM20262 Drosophila erecta Dere\GG22478 Drosophila yakuba Dyak\GE13347 Drosophila ananassae Dana\GF11169 Drosophila pseudoobscura pseudoobscura Dpse\GA19426 Drosophila persimilis Dper\GL17005 Drosophila willistoni Dwil\GK15605 Drosophila virilis Dvir\GJ21810 Drosophila mojavensis Dmoj\GI18784 Drosophila grimshawi Dgri\GH20067
Stocks & Reagents
Stocks Listed in FlyBase ( 10 )
Bloomington	21385 y1 w67c23; P{EPgy2}CG6191EY12761
Harvard	- P{XP}CG6191d03529 - PBac{RB}CG6191e00920 - PBac{RB}CG6191e03779 - PBac{WH}CG6191f00477
Kyoto	113339 w*; P{GawB}CG6191NP3553 123651 w1118; P{RS3}CG6191CB-5484-3 125135 w1118; P{RS5}CG61915-HA-1196 105335 y* w*; P{GawB}CG6191NP7023 / CyO, P{UAS-lacZ.UW14}UW14
VDRC	v101387 P{KK109367}VIE-260B
Genomic Clones ( 2 )
	BACR14P04 BACR36J03 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 49 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH06193
Other clones	FI19824
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH26390 GH28893 GM04306 HL03670 LD30140 RE07776 RE25576 RE58558 SD04537
Other clones	8329 37034 106478 174547 180070 211070.1 523391 524353 571293 CK01.70B.C6 EK056043 EK106924 EK147940 EK189506 EK231938 EK256307 EK275739 EK287915 EN00461 EN03835 EN05228 EN16535 EP06408 ESG0116c.B21_E03 Fernando_27_G11 GM02421 RP001002865 RP001010289 RP001022005 RP001022260 RP001024846 RP001026332 RP001031996 RP001041144 RP001042650 RP001043771 RP001044893 RP001051355
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0027581 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36513
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells. (Stroschein-Stevenson et al., 2006)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_137046 NM_001274028 NM_001274029 RefSeq (Proteins) • NP_610890 NP_001260957 NP_001260958 DDBJ / EMBL / GenBank • AAD38609 AAF58349 AF145634 AGB93489 AGB93490 AI106930 AI402040 CW848204 CZ473411 CZ478752 CZ481534 CZ482948 Entrez Gene - A searchable database of RefSeq genes. • 36513 UniProtKB/TrEMBL • A1Z9G1 Q9Y138
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Cdk5/c-Abl linker protein Cables (IPR012388) Cyclin, N-terminal (IPR006671) Cyclin-like (IPR013763)
Linkouts
	BioGRID - A database of protein and genetic interactions • 62268 DroID - A comprehensive database of gene and protein interactions. • FBgn0027581 DRSC - Results from RNAi screens. • FBgn0027581 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0027581 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6191-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0027581 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36513 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36513 modMine - Data generated by the modENCODE project. • FBgn0027581 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • A1Z9G1
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	BcDNA:GH06193   CG6191 (Stroschein-Stevenson et al., 2006, Deloger et al., 2009, Jungreis et al., 2011, Zhang et al., 2008, Lipatov et al., 2005, Hayden and Bosco, 2008, Keleman et al., 2009.8.5, Gurudatta et al., 2012) Dromel_CG6191_FBtr0087678_mORF (Hayden and Bosco, 2008) unnamed (Cowan and Henkemeyer, 2000)
Name Synonym
Secondary FlyBase IDs
References ( 23 )
Generate a list of	All references relating to this gene ( 23 )
List References by type	Research paper  ( 9 ) Supplementary material  ( 5 ) Review  ( 1 ) Personal communication to FlyBase  ( 5 ) FlyBase analysis  ( 2 )
Recent research papers ( 2 )
	Djiane et al., 2013, EMBO J. 32(1): 60--71 Dissecting the mechanisms of Notch induced hyperplasia. [FBrf0220483] Gurudatta et al., 2012, Dev. Biol. 369(1): 124--132 The BEAF insulator regulates genes involved in cell polarity and neoplastic growth. [FBrf0219796] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...