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Gene Dmel\CG6191

General Information
Symbol	Dmel\CG6191	Species	D. melanogaster
Name		Annotation symbol	CG6191
Feature type	protein_coding_gene	FlyBase ID	FBgn0027581
Gene Model Status	Current	Stock availability	10 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	50B3-50B4	Sequence location	2R:9,468,091..9,480,841 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG6191 (FBgn0027581). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: cyclin-dependent protein kinase regulator activity. There is experimental evidence that it is involved in the biological process: phagocytosis, engulfment. 10 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Cdk5/c-Abl linker protein Cables; Cyclin, N-terminal; Cyclin-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: adult eye, larval Malpighian tubules. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, adult Malpighian tubules, adult heart, larval/adult fat body, adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1625281_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG6191. Gene sequence location is 2R:9468091..9480841.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features HFA05938 BKN29367
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 50B3-50B4   Limits computationally determined from genome sequence between P{lacW}drkk13809&P{EP}mip120EP606 and P{lacW}l(2)03105k16702&P{lacW}fl(2)dk16105
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG6191 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	5' UTR contains an ORF described as a putative conserved uORF (FBrf0204849); potential peptide 21aa in length.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG6191-RA FBtr0087678  NM_137046   3436   717
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG6191-PA   FBpp0086798   79.3   717   10.26     NP_610890   AAF58349
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Cdk5/c-Abl linker protein Cables (IPR012388) Cyclin, N-terminal (IPR006671) Cyclin-like (IPR013763)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA695214   AA695692   AA698042   AA950193   AE013599 AAF58349   AF145634 AAD38609   AI106930   AI402040   AI406174   AI517829   AI532891   BG633589   BI167398   BI228132   BI371630   CA805124   CO152804   CO154278   CO155026   CO178209   CO266922   CO272369   CO307964   CO313230   CO318999   CO320745   CO323013   CO327178   CO338339   CW848204   CZ473411   CZ478752   CZ481534   CZ482948   EC078455   EC199125   EC205090   EC218572   EC227372   EC237142   EC239221   EC243728   EC263490   EC265638   EC267369   GH741403   GH747266   GH765130   GH765790   GH768258   GH769354   GH769427   GH769617   GH769644   GH769973   GH779312   GH779585
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9Y138 A1Z9G1
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0027581    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0027581 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0027581 expression level Developmental Stage   Expression Level embryo 00-02hr    2306 embryo 02-04hr    1406 embryo 04-06hr    1079 embryo 06-08hr    1106 embryo 08-10hr    1508 embryo 10-12hr    1920 embryo 12-14hr    1848 embryo 14-16hr    1918 embryo 16-18hr    1708 embryo 18-20hr    1804 embryo 20-22hr    2359 embryo 22-24hr    2495 larva L1    1730 larva L2    1172 larva L3 12hr old    1069 larva L3 puffstage 1-2    901 larva L3 puffstage 3-6    1852 larva L3 puffstage 7-9    2503 white prepupae new    2127 white prepupae 12hr    4816 white prepupae 24hr    2294 pupae 2d postWPP    2346 pupae 3d postWPP    1826 pupae 4d postWPP    1911 adult male 01day    1631 adult male 05day    1767 adult male 30day    1892 adult female 01day    2076 adult female 05day    1820 adult female 30day    1872 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2306) embryo 02-04hr  (1406) embryo 04-06hr  (1079) embryo 06-08hr  (1106) embryo 08-10hr  (1508) embryo 10-12hr  (1920) embryo 12-14hr  (1848) embryo 14-16hr  (1918) embryo 16-18hr  (1708) embryo 18-20hr  (1804) embryo 20-22hr  (2359) embryo 22-24hr  (2495) larva L1  (1730) larva L2  (1172) larva L3 12hr old  (1069) larva L3 puffstage 1-2  (901) larva L3 puffstage 3-6  (1852) larva L3 puffstage 7-9  (2503) white prepupae new  (2127) white prepupae 12hr  (4816) white prepupae 24hr  (2294) pupae 2d postWPP  (2346) pupae 3d postWPP  (1826) pupae 4d postWPP  (1911) adult male 01day  (1631) adult male 05day  (1767) adult male 30day  (1892) adult female 01day  (2076) adult female 05day  (1820) adult female 30day  (1872) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2306) embryo 02-04hr  1406 embryo 04-06hr    1079 embryo 06-08hr    1106 embryo 08-10hr  1508 embryo 10-12hr  (1920) embryo 12-14hr  (1848) embryo 14-16hr  (1918) embryo 16-18hr  (1708) embryo 18-20hr  (1804) embryo 20-22hr  (2359) embryo 22-24hr  (2495) larva L1  (1730) larva L2    1172 larva L3 12hr old    1069 larva L3 puffstage 1-2    901 larva L3 puffstage 3-6  (1852) larva L3 puffstage 7-9  (2503) white prepupae new  (2127) white prepupae 12hr  (4816) white prepupae 24hr  (2294) pupae 2d postWPP  (2346) pupae 3d postWPP  (1826) pupae 4d postWPP  (1911) adult male 01day  (1631) adult male 05day  (1767) adult male 30day  (1892) adult female 01day  (2076) adult female 05day  (1820) adult female 30day  (1872) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2306 embryo 02-04hr    1406 embryo 04-06hr    1079 embryo 06-08hr    1106 embryo 08-10hr    1508 embryo 10-12hr    1920 embryo 12-14hr    1848 embryo 14-16hr    1918 embryo 16-18hr    1708 embryo 18-20hr    1804 embryo 20-22hr    2359 embryo 22-24hr    2495 larva L1    1730 larva L2    1172 larva L3 12hr old    1069 larva L3 puffstage 1-2    901 larva L3 puffstage 3-6    1852 larva L3 puffstage 7-9    2503 white prepupae new    2127 white prepupae 12hr    4816 white prepupae 24hr    2294 pupae 2d postWPP    2346 pupae 3d postWPP    1826 pupae 4d postWPP    1911 adult male 01day    1631 adult male 05day    1767 adult male 30day    1892 adult female 01day    2076 adult female 05day    1820 adult female 30day    1872 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2306 embryo 02-04hr    1406 embryo 04-06hr    1079 embryo 06-08hr    1106 embryo 08-10hr    1508 embryo 10-12hr    1920 embryo 12-14hr    1848 embryo 14-16hr    1918 embryo 16-18hr    1708 embryo 18-20hr    1804 embryo 20-22hr    2359 embryo 22-24hr    2495 larva L1    1730 larva L2    1172 larva L3 12hr old    1069 larva L3 puffstage 1-2    901 larva L3 puffstage 3-6    1852 larva L3 puffstage 7-9    2503 white prepupae new    2127 white prepupae 12hr    4816 white prepupae 24hr    2294 pupae 2d postWPP    2346 pupae 3d postWPP    1826 pupae 4d postWPP    1911 adult male 01day    1631 adult male 05day    1767 adult male 30day    1892 adult female 01day    2076 adult female 05day    1820 adult female 30day    1872 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0027581 expression level Developmental Stage   Expression Level embryo 00-02hr    2306 embryo 02-04hr    1406 embryo 04-06hr    1079 embryo 06-08hr    1106 embryo 08-10hr    1508 embryo 10-12hr    1920 embryo 12-14hr    1848 embryo 14-16hr    1918 embryo 16-18hr    1708 embryo 18-20hr    1804 embryo 20-22hr    2359 embryo 22-24hr    2495 larva L1    1730 larva L2    1172 larva L3 12hr old    1069 larva L3 puffstage 1-2    901 larva L3 puffstage 3-6    1852 larva L3 puffstage 7-9    2503 white prepupae new    2127 white prepupae 12hr    4816 white prepupae 24hr    2294 pupae 2d postWPP    2346 pupae 3d postWPP    1826 pupae 4d postWPP    1911 adult male 01day    1631 adult male 05day    1767 adult male 30day    1892 adult female 01day    2076 adult female 05day    1820 adult female 30day    1872 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2306) embryo 02-04hr  (1406) embryo 04-06hr  (1079) embryo 06-08hr  (1106) embryo 08-10hr  (1508) embryo 10-12hr  (1920) embryo 12-14hr  (1848) embryo 14-16hr  (1918) embryo 16-18hr  (1708) embryo 18-20hr  (1804) embryo 20-22hr  (2359) embryo 22-24hr  (2495) larva L1  (1730) larva L2  (1172) larva L3 12hr old  (1069) larva L3 puffstage 1-2  (901) larva L3 puffstage 3-6  (1852) larva L3 puffstage 7-9  (2503) white prepupae new  (2127) white prepupae 12hr  (4816) white prepupae 24hr  (2294) pupae 2d postWPP  (2346) pupae 3d postWPP  (1826) pupae 4d postWPP  (1911) adult male 01day  (1631) adult male 05day  (1767) adult male 30day  (1892) adult female 01day  (2076) adult female 05day  (1820) adult female 30day  (1872) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  2306 embryo 02-04hr  1406 embryo 04-06hr    1079 embryo 06-08hr    1106 embryo 08-10hr  1508 embryo 10-12hr  1920 embryo 12-14hr  1848 embryo 14-16hr  1918 embryo 16-18hr  1708 embryo 18-20hr  1804 embryo 20-22hr  2359 embryo 22-24hr  (2495) larva L1  1730 larva L2    1172 larva L3 12hr old    1069 larva L3 puffstage 1-2    901 larva L3 puffstage 3-6  1852 larva L3 puffstage 7-9  (2503) white prepupae new  2127 white prepupae 12hr  (4816) white prepupae 24hr  2294 pupae 2d postWPP  2346 pupae 3d postWPP  1826 pupae 4d postWPP  1911 adult male 01day  1631 adult male 05day  1767 adult male 30day  1892 adult female 01day  2076 adult female 05day  1820 adult female 30day  1872 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2306 embryo 02-04hr    1406 embryo 04-06hr    1079 embryo 06-08hr    1106 embryo 08-10hr    1508 embryo 10-12hr    1920 embryo 12-14hr    1848 embryo 14-16hr    1918 embryo 16-18hr    1708 embryo 18-20hr    1804 embryo 20-22hr    2359 embryo 22-24hr    2495 larva L1    1730 larva L2    1172 larva L3 12hr old    1069 larva L3 puffstage 1-2    901 larva L3 puffstage 3-6    1852 larva L3 puffstage 7-9    2503 white prepupae new    2127 white prepupae 12hr    4816 white prepupae 24hr    2294 pupae 2d postWPP    2346 pupae 3d postWPP    1826 pupae 4d postWPP    1911 adult male 01day    1631 adult male 05day    1767 adult male 30day    1892 adult female 01day    2076 adult female 05day    1820 adult female 30day    1872 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2306 embryo 02-04hr    1406 embryo 04-06hr    1079 embryo 06-08hr    1106 embryo 08-10hr    1508 embryo 10-12hr    1920 embryo 12-14hr    1848 embryo 14-16hr    1918 embryo 16-18hr    1708 embryo 18-20hr    1804 embryo 20-22hr    2359 embryo 22-24hr    2495 larva L1    1730 larva L2    1172 larva L3 12hr old    1069 larva L3 puffstage 1-2    901 larva L3 puffstage 3-6    1852 larva L3 puffstage 7-9    2503 white prepupae new    2127 white prepupae 12hr    4816 white prepupae 24hr    2294 pupae 2d postWPP    2346 pupae 3d postWPP    1826 pupae 4d postWPP    1911 adult male 01day    1631 adult male 05day    1767 adult male 30day    1892 adult female 01day    2076 adult female 05day    1820 adult female 30day    1872 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0027581    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0027581 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: adult eye, larval Malpighian tubules. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, adult Malpighian tubules, adult heart, larval/adult fat body, adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0027581 expression level Tissue   Expression Level Larval Central Nervous System    142.95 Larval Midgut    115.9 Larval Hindgut    160.1 Larval Malpighian Tubules    1359.8 Larval Fat Body    243.1 Larval Salivary Gland    71.2 Larval Trachea    253.15 Larval Carcass    125.225 Adult Head    195.3 Adult Eye    599.3 Adult Brain    489.1 Adult Thoracic-Abdominal Ganglion    392.9 Adult Crop    136.9 Adult Midgut    249.6 Adult Hindgut    117.3 Adult Malpighian Tubules    358.3 Adult Fat Body    106.6 Adult Salivary Gland    138.9 Adult Heart    201.35 Adult VirginFemale Spermatheca    109.6 Adult InseminatedFemale Spermatheca    100 Adult Ovary    166.2 Adult Testis    39.3 Adult Male Accessory Gland    236.5 Adult Carcass    124.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    142.95 Larval Midgut    115.9 Larval Hindgut    160.1 Larval Malpighian Tubules  (1359.8) Larval Fat Body    243.1 Larval Salivary Gland    71.2 Larval Trachea    253.15 Larval Carcass    125.225 Adult Head    195.3 Adult Eye  (599.3) Adult Brain    489.1 Adult Thoracic-Abdominal Ganglion    392.9 Adult Crop    136.9 Adult Midgut    249.6 Adult Hindgut    117.3 Adult Malpighian Tubules    358.3 Adult Fat Body    106.6 Adult Salivary Gland    138.9 Adult Heart    201.35 Adult VirginFemale Spermatheca    109.6 Adult InseminatedFemale Spermatheca    100 Adult Ovary    166.2 Adult Testis    39.3 Adult Male Accessory Gland    236.5 Adult Carcass    124.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    142.95 Larval Midgut    115.9 Larval Hindgut    160.1 Larval Malpighian Tubules  (1359.8) Larval Fat Body    243.1 Larval Salivary Gland    71.2 Larval Trachea    253.15 Larval Carcass    125.225 Adult Head    195.3 Adult Eye    599.3 Adult Brain    489.1 Adult Thoracic-Abdominal Ganglion    392.9 Adult Crop    136.9 Adult Midgut    249.6 Adult Hindgut    117.3 Adult Malpighian Tubules    358.3 Adult Fat Body    106.6 Adult Salivary Gland    138.9 Adult Heart    201.35 Adult VirginFemale Spermatheca    109.6 Adult InseminatedFemale Spermatheca    100 Adult Ovary    166.2 Adult Testis    39.3 Adult Male Accessory Gland    236.5 Adult Carcass    124.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    142.95 Larval Midgut    115.9 Larval Hindgut    160.1 Larval Malpighian Tubules    1359.8 Larval Fat Body    243.1 Larval Salivary Gland    71.2 Larval Trachea    253.15 Larval Carcass    125.225 Adult Head    195.3 Adult Eye    599.3 Adult Brain    489.1 Adult Thoracic-Abdominal Ganglion    392.9 Adult Crop    136.9 Adult Midgut    249.6 Adult Hindgut    117.3 Adult Malpighian Tubules    358.3 Adult Fat Body    106.6 Adult Salivary Gland    138.9 Adult Heart    201.35 Adult VirginFemale Spermatheca    109.6 Adult InseminatedFemale Spermatheca    100 Adult Ovary    166.2 Adult Testis    39.3 Adult Male Accessory Gland    236.5 Adult Carcass    124.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0027581 expression level Tissue   Expression Level Larval Central Nervous System    142.95 Larval Midgut    115.9 Larval Hindgut    160.1 Larval Malpighian Tubules    1359.8 Larval Fat Body    243.1 Larval Salivary Gland    71.2 Larval Trachea    253.15 Larval Carcass    125.225 Adult Head    195.3 Adult Eye    599.3 Adult Brain    489.1 Adult Thoracic-Abdominal Ganglion    392.9 Adult Crop    136.9 Adult Midgut    249.6 Adult Hindgut    117.3 Adult Malpighian Tubules    358.3 Adult Fat Body    106.6 Adult Salivary Gland    138.9 Adult Heart    201.35 Adult VirginFemale Spermatheca    109.6 Adult InseminatedFemale Spermatheca    100 Adult Ovary    166.2 Adult Testis    39.3 Adult Male Accessory Gland    236.5 Adult Carcass    124.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    142.95 Larval Midgut    115.9 Larval Hindgut    160.1 Larval Malpighian Tubules  (1359.8) Larval Fat Body    243.1 Larval Salivary Gland    71.2 Larval Trachea    253.15 Larval Carcass    125.225 Adult Head    195.3 Adult Eye  599.3 Adult Brain    489.1 Adult Thoracic-Abdominal Ganglion    392.9 Adult Crop    136.9 Adult Midgut    249.6 Adult Hindgut    117.3 Adult Malpighian Tubules    358.3 Adult Fat Body    106.6 Adult Salivary Gland    138.9 Adult Heart    201.35 Adult VirginFemale Spermatheca    109.6 Adult InseminatedFemale Spermatheca    100 Adult Ovary    166.2 Adult Testis    39.3 Adult Male Accessory Gland    236.5 Adult Carcass    124.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    142.95 Larval Midgut    115.9 Larval Hindgut    160.1 Larval Malpighian Tubules  1359.8 Larval Fat Body    243.1 Larval Salivary Gland    71.2 Larval Trachea    253.15 Larval Carcass    125.225 Adult Head    195.3 Adult Eye    599.3 Adult Brain    489.1 Adult Thoracic-Abdominal Ganglion    392.9 Adult Crop    136.9 Adult Midgut    249.6 Adult Hindgut    117.3 Adult Malpighian Tubules    358.3 Adult Fat Body    106.6 Adult Salivary Gland    138.9 Adult Heart    201.35 Adult VirginFemale Spermatheca    109.6 Adult InseminatedFemale Spermatheca    100 Adult Ovary    166.2 Adult Testis    39.3 Adult Male Accessory Gland    236.5 Adult Carcass    124.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    142.95 Larval Midgut    115.9 Larval Hindgut    160.1 Larval Malpighian Tubules    1359.8 Larval Fat Body    243.1 Larval Salivary Gland    71.2 Larval Trachea    253.15 Larval Carcass    125.225 Adult Head    195.3 Adult Eye    599.3 Adult Brain    489.1 Adult Thoracic-Abdominal Ganglion    392.9 Adult Crop    136.9 Adult Midgut    249.6 Adult Hindgut    117.3 Adult Malpighian Tubules    358.3 Adult Fat Body    106.6 Adult Salivary Gland    138.9 Adult Heart    201.35 Adult VirginFemale Spermatheca    109.6 Adult InseminatedFemale Spermatheca    100 Adult Ovary    166.2 Adult Testis    39.3 Adult Male Accessory Gland    236.5 Adult Carcass    124.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    195.3   NA  Eye    599.3   NA  Brain    489.1   142.95  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    392.9   NA  Crop    136.9   115.9  Midgut    249.6   160.1  Hindgut    117.3   1359.8  Malpighian Tubules    358.3   243.1  Fat Body    106.6   71.2  Salivary Gland    138.9   NA  Heart    201.35   253.15  Trachea    NA   NA  VirginFemale Spermatheca    109.6   NA  InseminatedFemale Spermatheca    100   NA  Ovary    166.2   NA  Testis    39.3   NA  Male Accessory Gland    236.5   125.225  Carcass    124.5 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_27
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0027581 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6191-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable CG6191EY12761 Sterility Allele fertile CG6191EY12761 Phenotype manifest in Allele
Classical Alleles ( 9 )
For All Classical Alleles Show
Allele of CG6191 Class Mutagen Stocks Known lesion CG61915-HA-1196 1 -- CG6191CB-5484-3 1 -- CG6191d03529 P-element activity 1 -- CG6191e00920 piggyBac transposase 1 -- CG6191e03779 piggyBac transposase 1 -- CG6191EY12761 P-element activity 1 -- CG6191f00477 piggyBac transposase 1 -- CG6191NP3553 1 -- CG6191NP7023 1 --
Alleles Carried on Transgenic Constructs ( 1 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG6191 Class Mutagen Stocks Known lesion CG6191KK109367 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD6583} NA P{KK109367} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}EP2007 NA P{EPgy2}CG6191EY12761 NA P{XP}CG6191d03529 NA miscellaneous insertions P{RS3}CG6191CB-5484-3 NA P{RS5}CG61915-HA-1196 NA PBac{RB}CG6191e00920 NA PBac{RB}CG6191e03779 NA PBac{WH}CG6191f00477 NA insertion of enhancer trap P{lacW}l(2)SH0237SH0237 No insertion of enhancer trap binary system P{GawB}CG6191NP3553 No P{GawB}CG6191NP7023 No
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
phagocytosis, engulfment inferred from mutant phenotype (Stroschein-Stevenson et al., 2006)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
cyclin-dependent protein kinase regulator activity inferred from electronic annotation with InterPro:IPR012388 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
regulation of cell cycle inferred from electronic annotation with InterPro:IPR012388 (FlyBase Curators et al., 2004-) regulation of cell division inferred from electronic annotation with InterPro:IPR012388 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG6191 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 62268 DroID - A comprehensive database of gene and protein interactions. • FBgn0027581 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36513
Orthologs
Genome-wide drosophilid orthologs	Dana\GF11169 Dere\GG22478 Dgri\GH20067 Dmoj\GI18784 Dper\GL17005 Dpse\GA19426 Dsec\GM20262 Dsim\GD25748 Dvir\GJ21810 Dwil\GK15605 Dyak\GE13347
Curated drosophilid orthologs	Dpse\GA19426
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL005863-PA Aedes aegypti (mosquito) AGAP010843-PA Anopheles gambiae (mosquito) XP_623648.1 Apis mellifera (honey bee) XP_001943266.1 Acyrthosiphon pisum (pea aphid) BGIBMGA002977-PA Bombyx mori (silk worm) ENSBTAP00000027714 Bos taurus (bovine) CN11607 Caenorhabditis brenneri (small nematode) CN19031 Caenorhabditis brenneri (small nematode) CBP31359 Caenorhabditis briggsae (nematode) CE40171 Caenorhabditis elegans (worm) ENSCAFP00000034692 Canis familiaris (dog) ENSCINP00000013601 Ciona intestinalis (sea squirt) CPIJ019833 Culex pipens (mosquito) ENSCPOP00000001774 Cavia porcellus (guinea pig) RP37781 Caenorhabditis remanei (nematode) 221978 Capitella spl (polychaete worm) 104852 Daphnia pulex (daphnia) ENSDARP00000083640 Danio rerio (zebra fish) ENSECAP00000013605 Equus caballus (horse) ENSGACP00000022843 Gymnopilus aculeatus (mushroom) ENSGALP00000008556 Gallus gallus (chicken) ENSP00000256925 Homo sapiens (human) LmjF28.2230 Leishmania major (virus) ENSMODP00000020927 Monodelphis domestica (gray opossum) ENSMMUP00000006791 Macaca mulatta (rhesus monkey) ENSMUSP00000040639 Mus musculus (house mouse) XP_001606210.1 Nasonia vitripennis (wasp) ENSORLP00000018658 Oryzias latipes (japanese killifish) PHUM000167-PA Pediculus humanus (human body louse) ENSPPYP00000012521 Pongo pygmaeus (orangutan) ENSPTRP00000016863 Pan troglodytes (chimpanzee) PVX_113445 Plasmodium vivax (protozoal parasite) ENSRNOP00000017187 Rattus norvegicus (norway rat) Smp_134360 Schistosoma mansoni (trematode parasite) 57893 Trichoplax adhaerens (metazoa) XP_974680.2 Tribolium castaneum (red flour beetle) Tc00.1047053509203.20 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053511017.30 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000017879 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000031941 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000030404 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV11686 LH19595 ISCW019385 FBgn0231027 FBgn0217610 FBgn0208928 FBgn0197030 FBgn0175145 JGI_V11_53154 FBgn0079423 FBgn0154609 FBgn0141523 FBgn0127531 FBgn0114649 FBgn0088209 CPIJ019832 CPIJ019833 BGIBMGA002977 ACYPI002029 GB18186 AGAP010843 AAEL005863 PB24368 PHUM586210 GLEAN_13369
Stocks & Reagents
Stocks Listed in FlyBase ( 10 )
Bloomington	21385 y1 w67c23; P{EPgy2}CG6191EY12761
Harvard	- P{XP}CG6191d03529 - PBac{RB}CG6191e00920 - PBac{RB}CG6191e03779 - PBac{WH}CG6191f00477
Kyoto	113339 w*; P{GawB}CG6191NP3553 123651 w1118; P{RS3}CG6191CB-5484-3 125135 w1118; P{RS5}CG61915-HA-1196 105335 y* w*; P{GawB}CG6191NP7023 / CyO, P{UAS-lacZ.UW14}UW14
VDRC	v101387 P{KK109367}VIE-260B
Genomic Clones ( 2 )
	BACR14P04 BACR36J03 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 47 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH06193
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH26390 GH28893 GM04306 HL03670 LD30140 RE07776 RE25576 RE58558 SD04537
Other clones	8329 37034 106478 174547 180070 211070.1 523391 524353 571293 CK01.70B.C6 EK056043 EK106924 EK147940 EK189506 EK231938 EK256307 EK275739 EK287915 EN00461 EN03835 EN05228 EN16535 EP06408 ESG0116c.B21_E03 GM02421 RP001002865 RP001010289 RP001022005 RP001022260 RP001024846 RP001026332 RP001031996 RP001041144 RP001042650 RP001043771 RP001044893 RP001051355
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0027581 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36513
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells. (Stroschein-Stevenson et al., 2006)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_137046 RefSeq (Proteins) • NP_610890 DDBJ / EMBL / GenBank • AAD38609 AAF58349 AF145634 AI106930 AI402040 CW848204 CZ473411 CZ478752 CZ481534 CZ482948 Entrez Gene - A searchable database of RefSeq genes. • 36513 UniProtKB/TrEMBL • A1Z9G1 Q9Y138
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Cdk5/c-Abl linker protein Cables (IPR012388) Cyclin, N-terminal (IPR006671) Cyclin-like (IPR013763)
Linkouts
	BioGRID - A database of protein and genetic interactions • 62268 DroID - A comprehensive database of gene and protein interactions. • FBgn0027581 DRSC - Results from RNAi screens. • FBgn0027581 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0027581 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6191-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0027581 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36513 InParanoid A subset of ortholog calls from InParanoid. • AAEL005863-PA Aedes aegypti (mosquito) AGAP010843-PA Anopheles gambiae (mosquito) XP_623648.1 Apis mellifera (honey bee) XP_001943266.1 Acyrthosiphon pisum (pea aphid) BGIBMGA002977-PA Bombyx mori (silk worm) ENSBTAP00000027714 Bos taurus (bovine) CN11607 Caenorhabditis brenneri (small nematode) CN19031 Caenorhabditis brenneri (small nematode) CBP31359 Caenorhabditis briggsae (nematode) CE40171 Caenorhabditis elegans (worm) ENSCAFP00000034692 Canis familiaris (dog) ENSCINP00000013601 Ciona intestinalis (sea squirt) CPIJ019833 Culex pipens (mosquito) ENSCPOP00000001774 Cavia porcellus (guinea pig) RP37781 Caenorhabditis remanei (nematode) 221978 Capitella spl (polychaete worm) 104852 Daphnia pulex (daphnia) ENSDARP00000083640 Danio rerio (zebra fish) ENSECAP00000013605 Equus caballus (horse) ENSGACP00000022843 Gymnopilus aculeatus (mushroom) ENSGALP00000008556 Gallus gallus (chicken) ENSP00000256925 Homo sapiens (human) LmjF28.2230 Leishmania major (virus) ENSMODP00000020927 Monodelphis domestica (gray opossum) ENSMMUP00000006791 Macaca mulatta (rhesus monkey) ENSMUSP00000040639 Mus musculus (house mouse) XP_001606210.1 Nasonia vitripennis (wasp) ENSORLP00000018658 Oryzias latipes (japanese killifish) PHUM000167-PA Pediculus humanus (human body louse) ENSPPYP00000012521 Pongo pygmaeus (orangutan) ENSPTRP00000016863 Pan troglodytes (chimpanzee) PVX_113445 Plasmodium vivax (protozoal parasite) ENSRNOP00000017187 Rattus norvegicus (norway rat) Smp_134360 Schistosoma mansoni (trematode parasite) 57893 Trichoplax adhaerens (metazoa) XP_974680.2 Tribolium castaneum (red flour beetle) Tc00.1047053509203.20 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053511017.30 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000017879 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000031941 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000030404 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36513 modMine - Data generated by the modENCODE project. • FBgn0027581 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV11686 LH19595 ISCW019385 FBgn0231027 FBgn0217610 FBgn0208928 FBgn0197030 FBgn0175145 JGI_V11_53154 FBgn0079423 FBgn0154609 FBgn0141523 FBgn0127531 FBgn0114649 FBgn0088209 CPIJ019832 CPIJ019833 BGIBMGA002977 ACYPI002029 GB18186 AGAP010843 AAEL005863 PB24368 PHUM586210 GLEAN_13369
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	BcDNA:GH06193   CG6191 (Stroschein-Stevenson et al., 2006, Deloger et al., 2009, Zhang et al., 2008, Lipatov et al., 2005, Hayden and Bosco, 2008, Keleman et al., 2009.8.5) Dromel_CG6191_FBtr0087678_mORF (Hayden and Bosco, 2008) unnamed (Cowan and Henkemeyer, 2000)
Name Synonym
Secondary FlyBase IDs
References ( 19 )
Research paper	Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Deloger et al., 2009, Gene 439(1-2): 55--62 Identification of expressed transposable element insertions in the sequenced genome of Drosophila melanogaster. [FBrf0207990] Hayden and Bosco, 2008, BMC Genomics 9: 61 Comparative genomic analysis of novel conserved peptide upstream open reading frames in Drosophila melanogaster and other dipteran species. [FBrf0204849] Zhang et al., 2008, Dev. Cell 14(4): 481--493 Epigenetic blocking of an enhancer region controls irradiation-induced proapoptotic gene expression in Drosophila embryos. [FBrf0204622] Stroschein-Stevenson et al., 2006, PLoS Biol. 4(1): 87--99 Identification of Drosophila gene products required for phagocytosis of Candida albicans. [FBrf0191376] Lipatov et al., 2005, BMC Biol. 3: 24 Paucity of chimeric gene-transposable element transcripts in the Drosophila melanogaster genome. [FBrf0189752] Ward et al., 2002, genesis 34(1-2): 46--50 GAL4 enhancer trap patterns during Drosophila development. [FBrf0152375]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Hayden and Bosco, 2008, BMC Genomics: File 1: Conserved peptide uORF and associated mORF amino acid sequences in Drosophila melanogaster. [FBrf0205942] Oh et al., 2003, Genetics 163(1): Table S1. [FBrf0157097]
Review	Cowan and Henkemeyer, 2000, Neuron 26(3): 543--544 More cables to Abl. [FBrf0131020]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215]
FlyBase analysis	FlyBase Curators, 2008, Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. [FBrf0202955] FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	Gene Disruption Project members and Exelixis, 2005, Genomic mapping of Exelixis insertion collection. Genomic mapping of Exelixis insertion collection. [FBrf0184340] Gene Disruption Project members, 2001-, [title not yet available] [title not yet available] [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]