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Gene Dmel\CG5867

General Information
Symbol	Dmel\CG5867	Species	D. melanogaster
Name		Annotation symbol	CG5867
Feature type	protein_coding_gene	FlyBase ID	FBgn0027586
Gene Model Status	Current	Stock availability	3 publicly available
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	34A11-34A11	Sequence location	2L:13,236,494..13,239,297 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG5867 (FBgn0027586). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. The biological processes in which it is involved are not known. 4 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Haemolymph juvenile hormone binding. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of extremely low expression. Peak expression observed during late pupal stages, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult crop, adult hindgut, larval trachea, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval/adult midgut, larval hindgut, adult Malpighian tubules, adult heart, adult fat body, larval/adult salivary gland, adult spermathecae, adult male accessory gland, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1632650_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG5867. Gene sequence location is 2L:13236494..13239297.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 34A11-34A11   Limits computationally determined from genome sequence between P{lacW}l(2)k11328k11328&P{lacW}l(2)k10105k10105 and P{EP}EP850&P{lacW}l(2)k05911k05911
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG5867 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.47
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG5867-RA FBtr0080449  NM_135781   1044   262
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG5867-PA   FBpp0080029   29.6   262   5.81     NP_609625   AAF53270
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Haemolymph juvenile hormone binding (IPR010562)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA697554   AA735803   AE014134 AAF53270   AF145628 AAD38603   AI062307   AI063665   AI107709   AI107751   AI108321   AI110018   AI113486   AI114384   AI134935   AI135812   AI388278   AI402010   AI402014   AI405515   AI513762   AI513769   AI517611   AY089660 AAL90398   BI567192   BI582491   BI582543   BI584015   BI584924   BI606403   BI617081   BI622296   BT050440   CO268070   CO272963   CO278911   CO278919   CO283819   CO285464   CO298186   CO312900   CO315919   EC200139   EC208502   EC221579   EC232753   EC237057   EC243786
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9Y143 Q8SXF9
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult crop, adult hindgut, larval trachea, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval/adult midgut, larval hindgut, adult Malpighian tubules, adult heart, adult fat body, larval/adult salivary gland, adult spermathecae, adult male accessory gland, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    115.575 Larval Midgut    271.9 Larval Hindgut    209.8 Larval Malpighian Tubules    24.1 Larval Fat Body    33.5 Larval Salivary Gland    122.9 Larval Trachea    2154.825 Larval Carcass    360.875 Adult Head    2608 Adult Eye    807.8 Adult Brain    75 Adult Thoracic-Abdominal Ganglion    29.6 Adult Crop    4835.1 Adult Midgut    254.7 Adult Hindgut    1833.5 Adult Malpighian Tubules    193.9 Adult Fat Body    288.7 Adult Salivary Gland    378.9 Adult Heart    289.225 Adult VirginFemale Spermatheca    283 Adult InseminatedFemale Spermatheca    287.6 Adult Ovary    20.5 Adult Testis    38.2 Adult Male Accessory Gland    127.4 Adult Carcass    1462.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    115.575 Larval Midgut    271.9 Larval Hindgut    209.8 Larval Malpighian Tubules    24.1 Larval Fat Body    33.5 Larval Salivary Gland    122.9 Larval Trachea  (2154.825) Larval Carcass    360.875 Adult Head  (2608) Adult Eye  (807.8) Adult Brain    75 Adult Thoracic-Abdominal Ganglion    29.6 Adult Crop  (4835.1) Adult Midgut    254.7 Adult Hindgut  (1833.5) Adult Malpighian Tubules    193.9 Adult Fat Body    288.7 Adult Salivary Gland    378.9 Adult Heart    289.225 Adult VirginFemale Spermatheca    283 Adult InseminatedFemale Spermatheca    287.6 Adult Ovary    20.5 Adult Testis    38.2 Adult Male Accessory Gland    127.4 Adult Carcass  (1462.8) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    115.575 Larval Midgut    271.9 Larval Hindgut    209.8 Larval Malpighian Tubules    24.1 Larval Fat Body    33.5 Larval Salivary Gland    122.9 Larval Trachea  (2154.825) Larval Carcass    360.875 Adult Head  (2608) Adult Eye    807.8 Adult Brain    75 Adult Thoracic-Abdominal Ganglion    29.6 Adult Crop  (4835.1) Adult Midgut    254.7 Adult Hindgut  (1833.5) Adult Malpighian Tubules    193.9 Adult Fat Body    288.7 Adult Salivary Gland    378.9 Adult Heart    289.225 Adult VirginFemale Spermatheca    283 Adult InseminatedFemale Spermatheca    287.6 Adult Ovary    20.5 Adult Testis    38.2 Adult Male Accessory Gland    127.4 Adult Carcass  (1462.8) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    115.575 Larval Midgut    271.9 Larval Hindgut    209.8 Larval Malpighian Tubules    24.1 Larval Fat Body    33.5 Larval Salivary Gland    122.9 Larval Trachea    2154.825 Larval Carcass    360.875 Adult Head    2608 Adult Eye    807.8 Adult Brain    75 Adult Thoracic-Abdominal Ganglion    29.6 Adult Crop    4835.1 Adult Midgut    254.7 Adult Hindgut    1833.5 Adult Malpighian Tubules    193.9 Adult Fat Body    288.7 Adult Salivary Gland    378.9 Adult Heart    289.225 Adult VirginFemale Spermatheca    283 Adult InseminatedFemale Spermatheca    287.6 Adult Ovary    20.5 Adult Testis    38.2 Adult Male Accessory Gland    127.4 Adult Carcass    1462.8 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    115.575 Larval Midgut    271.9 Larval Hindgut    209.8 Larval Malpighian Tubules    24.1 Larval Fat Body    33.5 Larval Salivary Gland    122.9 Larval Trachea    2154.825 Larval Carcass    360.875 Adult Head    2608 Adult Eye    807.8 Adult Brain    75 Adult Thoracic-Abdominal Ganglion    29.6 Adult Crop    4835.1 Adult Midgut    254.7 Adult Hindgut    1833.5 Adult Malpighian Tubules    193.9 Adult Fat Body    288.7 Adult Salivary Gland    378.9 Adult Heart    289.225 Adult VirginFemale Spermatheca    283 Adult InseminatedFemale Spermatheca    287.6 Adult Ovary    20.5 Adult Testis    38.2 Adult Male Accessory Gland    127.4 Adult Carcass    1462.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    115.575 Larval Midgut    271.9 Larval Hindgut    209.8 Larval Malpighian Tubules    24.1 Larval Fat Body    33.5 Larval Salivary Gland    122.9 Larval Trachea  (2154.825) Larval Carcass    360.875 Adult Head  (2608) Adult Eye  807.8 Adult Brain    75 Adult Thoracic-Abdominal Ganglion    29.6 Adult Crop  (4835.1) Adult Midgut    254.7 Adult Hindgut  (1833.5) Adult Malpighian Tubules    193.9 Adult Fat Body    288.7 Adult Salivary Gland    378.9 Adult Heart    289.225 Adult VirginFemale Spermatheca    283 Adult InseminatedFemale Spermatheca    287.6 Adult Ovary    20.5 Adult Testis    38.2 Adult Male Accessory Gland    127.4 Adult Carcass  (1462.8) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    115.575 Larval Midgut    271.9 Larval Hindgut    209.8 Larval Malpighian Tubules    24.1 Larval Fat Body    33.5 Larval Salivary Gland    122.9 Larval Trachea  (2154.825) Larval Carcass    360.875 Adult Head  (2608) Adult Eye    807.8 Adult Brain    75 Adult Thoracic-Abdominal Ganglion    29.6 Adult Crop  (4835.1) Adult Midgut    254.7 Adult Hindgut  (1833.5) Adult Malpighian Tubules    193.9 Adult Fat Body    288.7 Adult Salivary Gland    378.9 Adult Heart    289.225 Adult VirginFemale Spermatheca    283 Adult InseminatedFemale Spermatheca    287.6 Adult Ovary    20.5 Adult Testis    38.2 Adult Male Accessory Gland    127.4 Adult Carcass  1462.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    115.575 Larval Midgut    271.9 Larval Hindgut    209.8 Larval Malpighian Tubules    24.1 Larval Fat Body    33.5 Larval Salivary Gland    122.9 Larval Trachea    2154.825 Larval Carcass    360.875 Adult Head    2608 Adult Eye    807.8 Adult Brain    75 Adult Thoracic-Abdominal Ganglion    29.6 Adult Crop    4835.1 Adult Midgut    254.7 Adult Hindgut    1833.5 Adult Malpighian Tubules    193.9 Adult Fat Body    288.7 Adult Salivary Gland    378.9 Adult Heart    289.225 Adult VirginFemale Spermatheca    283 Adult InseminatedFemale Spermatheca    287.6 Adult Ovary    20.5 Adult Testis    38.2 Adult Male Accessory Gland    127.4 Adult Carcass    1462.8 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    2608   NA  Eye    807.8   NA  Brain    75   115.575  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    29.6   NA  Crop    4835.1   271.9  Midgut    254.7   209.8  Hindgut    1833.5   no informative data  Malpighian Tubules    193.9   no informative data  Fat Body    288.7   122.9  Salivary Gland    378.9   NA  Heart    289.225   2154.825  Trachea    NA   NA  VirginFemale Spermatheca    283   NA  InseminatedFemale Spermatheca    287.6   NA  Ovary    20.5   NA  Testis    38.2   NA  Male Accessory Gland    127.4   360.875  Carcass    1462.8 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    1 central nervous system, pupae P8    2 head, virgin 1-day female    176 head, virgin 4-day female    97 head, virgin 20-day female    165 head, mated 1-day female    83 head, mated 4-day female    103 head, mated 20-day female    178 head, mated 1-day male    172 head, mated 4-day male    124 head, mated 20-day male    250 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    43 digestive system, 4-day adult    27 digestive system, 20-day adult    26 fat body, larvae L3 wandering    1 fat body, white prepupae    1 fat body, pupae P8    10 carcass, larvae L3 wandering    7 carcass, 1-day adult    59 carcass, 4-day adult    66 carcass, 20-day adult    67 ovary, virgin 4-day female    2 ovary, mated 4-day female    1 testis, mated 4-day male    9 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    1 central nervous system, pupae P8    2 head, virgin 1-day female  (176) head, virgin 4-day female  (97) head, virgin 20-day female  (165) head, mated 1-day female  (83) head, mated 4-day female  (103) head, mated 20-day female  (178) head, mated 1-day male  (172) head, mated 4-day male  (124) head, mated 20-day male  (250) salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    16 digestive system, 1-day adult  (43) digestive system, 4-day adult  (27) digestive system, 20-day adult  26 fat body, larvae L3 wandering    1 fat body, white prepupae    1 fat body, pupae P8    10 carcass, larvae L3 wandering    7 carcass, 1-day adult  (59) carcass, 4-day adult  (66) carcass, 20-day adult  (67) ovary, virgin 4-day female    2 ovary, mated 4-day female    1 testis, mated 4-day male    9 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    1 central nervous system, pupae P8    2 head, virgin 1-day female  (176) head, virgin 4-day female    97 head, virgin 20-day female  (165) head, mated 1-day female    83 head, mated 4-day female  103 head, mated 20-day female  (178) head, mated 1-day male  (172) head, mated 4-day male  (124) head, mated 20-day male  (250) salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    43 digestive system, 4-day adult    27 digestive system, 20-day adult    26 fat body, larvae L3 wandering    1 fat body, white prepupae    1 fat body, pupae P8    10 carcass, larvae L3 wandering    7 carcass, 1-day adult    59 carcass, 4-day adult    66 carcass, 20-day adult    67 ovary, virgin 4-day female    2 ovary, mated 4-day female    1 testis, mated 4-day male    9 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    1 central nervous system, pupae P8    2 head, virgin 1-day female    176 head, virgin 4-day female    97 head, virgin 20-day female    165 head, mated 1-day female    83 head, mated 4-day female    103 head, mated 20-day female    178 head, mated 1-day male    172 head, mated 4-day male    124 head, mated 20-day male    250 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    43 digestive system, 4-day adult    27 digestive system, 20-day adult    26 fat body, larvae L3 wandering    1 fat body, white prepupae    1 fat body, pupae P8    10 carcass, larvae L3 wandering    7 carcass, 1-day adult    59 carcass, 4-day adult    66 carcass, 20-day adult    67 ovary, virgin 4-day female    2 ovary, mated 4-day female    1 testis, mated 4-day male    9 accessory gland, mated 4-day male    6 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    1 central nervous system, pupae P8    2 head, virgin 1-day female    176 head, virgin 4-day female    97 head, virgin 20-day female    165 head, mated 1-day female    83 head, mated 4-day female    103 head, mated 20-day female    178 head, mated 1-day male    172 head, mated 4-day male    124 head, mated 20-day male    250 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    43 digestive system, 4-day adult    27 digestive system, 20-day adult    26 fat body, larvae L3 wandering    1 fat body, white prepupae    1 fat body, pupae P8    10 carcass, larvae L3 wandering    7 carcass, 1-day adult    59 carcass, 4-day adult    66 carcass, 20-day adult    67 ovary, virgin 4-day female    2 ovary, mated 4-day female    1 testis, mated 4-day male    9 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    1 central nervous system, pupae P8    2 head, virgin 1-day female  (176) head, virgin 4-day female  (97) head, virgin 20-day female  (165) head, mated 1-day female  (83) head, mated 4-day female  (103) head, mated 20-day female  (178) head, mated 1-day male  (172) head, mated 4-day male  (124) head, mated 20-day male  (250) salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    16 digestive system, 1-day adult  (43) digestive system, 4-day adult  27 digestive system, 20-day adult  26 fat body, larvae L3 wandering    1 fat body, white prepupae    1 fat body, pupae P8    10 carcass, larvae L3 wandering    7 carcass, 1-day adult  (59) carcass, 4-day adult  (66) carcass, 20-day adult  (67) ovary, virgin 4-day female    2 ovary, mated 4-day female    1 testis, mated 4-day male    9 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    1 central nervous system, pupae P8    2 head, virgin 1-day female  (176) head, virgin 4-day female    97 head, virgin 20-day female  (165) head, mated 1-day female    83 head, mated 4-day female  103 head, mated 20-day female  (178) head, mated 1-day male  (172) head, mated 4-day male  124 head, mated 20-day male  (250) salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    43 digestive system, 4-day adult    27 digestive system, 20-day adult    26 fat body, larvae L3 wandering    1 fat body, white prepupae    1 fat body, pupae P8    10 carcass, larvae L3 wandering    7 carcass, 1-day adult    59 carcass, 4-day adult    66 carcass, 20-day adult    67 ovary, virgin 4-day female    2 ovary, mated 4-day female    1 testis, mated 4-day male    9 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    1 central nervous system, pupae P8    2 head, virgin 1-day female    176 head, virgin 4-day female    97 head, virgin 20-day female    165 head, mated 1-day female    83 head, mated 4-day female    103 head, mated 20-day female    178 head, mated 1-day male    172 head, mated 4-day male    124 head, mated 20-day male    250 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    43 digestive system, 4-day adult    27 digestive system, 20-day adult    26 fat body, larvae L3 wandering    1 fat body, white prepupae    1 fat body, pupae P8    10 carcass, larvae L3 wandering    7 carcass, 1-day adult    59 carcass, 4-day adult    66 carcass, 20-day adult    67 ovary, virgin 4-day female    2 ovary, mated 4-day female    1 testis, mated 4-day male    9 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of extremely low expression. Peak expression observed during late pupal stages, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    2 embryo 06-08hr    1 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    2 embryo 20-22hr    2 embryo 22-24hr    2 larva L1    2 larva L2    0 larva L3 12hr old    24 larva L3 puffstage 1-2    30 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    8 white prepupae new    6 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    5 pupae 3d postWPP    6 pupae 4d postWPP    69 adult male 01day    126 adult male 05day    110 adult male 30day    108 adult female 01day    79 adult female 05day    39 adult female 30day    34 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    2 embryo 06-08hr    1 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    2 embryo 20-22hr    2 embryo 22-24hr    2 larva L1    2 larva L2    0 larva L3 12hr old    24 larva L3 puffstage 1-2  (30) larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    8 white prepupae new    6 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    5 pupae 3d postWPP    6 pupae 4d postWPP  (69) adult male 01day  (126) adult male 05day  (110) adult male 30day  (108) adult female 01day  (79) adult female 05day  (39) adult female 30day  (34) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    2 embryo 06-08hr    1 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    2 embryo 20-22hr    2 embryo 22-24hr    2 larva L1    2 larva L2    0 larva L3 12hr old    24 larva L3 puffstage 1-2    30 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    8 white prepupae new    6 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    5 pupae 3d postWPP    6 pupae 4d postWPP    69 adult male 01day  (126) adult male 05day  (110) adult male 30day  (108) adult female 01day    79 adult female 05day    39 adult female 30day    34 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    2 embryo 06-08hr    1 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    2 embryo 20-22hr    2 embryo 22-24hr    2 larva L1    2 larva L2    0 larva L3 12hr old    24 larva L3 puffstage 1-2    30 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    8 white prepupae new    6 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    5 pupae 3d postWPP    6 pupae 4d postWPP    69 adult male 01day    126 adult male 05day    110 adult male 30day    108 adult female 01day    79 adult female 05day    39 adult female 30day    34 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    2 embryo 06-08hr    1 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    2 embryo 20-22hr    2 embryo 22-24hr    2 larva L1    2 larva L2    0 larva L3 12hr old    24 larva L3 puffstage 1-2    30 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    8 white prepupae new    6 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    5 pupae 3d postWPP    6 pupae 4d postWPP    69 adult male 01day    126 adult male 05day    110 adult male 30day    108 adult female 01day    79 adult female 05day    39 adult female 30day    34 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    2 embryo 06-08hr    1 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    2 embryo 20-22hr    2 embryo 22-24hr    2 larva L1    2 larva L2    0 larva L3 12hr old    24 larva L3 puffstage 1-2  30 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    8 white prepupae new    6 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    5 pupae 3d postWPP    6 pupae 4d postWPP  (69) adult male 01day  (126) adult male 05day  (110) adult male 30day  (108) adult female 01day  (79) adult female 05day  (39) adult female 30day  (34) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    2 embryo 06-08hr    1 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    2 embryo 20-22hr    2 embryo 22-24hr    2 larva L1    2 larva L2    0 larva L3 12hr old    24 larva L3 puffstage 1-2    30 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    8 white prepupae new    6 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    5 pupae 3d postWPP    6 pupae 4d postWPP    69 adult male 01day  126 adult male 05day  110 adult male 30day  108 adult female 01day    79 adult female 05day    39 adult female 30day    34 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    2 embryo 06-08hr    1 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    2 embryo 20-22hr    2 embryo 22-24hr    2 larva L1    2 larva L2    0 larva L3 12hr old    24 larva L3 puffstage 1-2    30 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    8 white prepupae new    6 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    5 pupae 3d postWPP    6 pupae 4d postWPP    69 adult male 01day    126 adult male 05day    110 adult male 30day    108 adult female 01day    79 adult female 05day    39 adult female 30day    34 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    7 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    5 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    39 Cadmium 50 mM 12 hrs, larvae L3    31 Cadmium 50 mM 48 hrs, 4-day adult    17 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3    20 Ethanol 5% 3 hrs, larvae L3    35 Ethanol 10% 3 hrs, larvae L3    24 Caffeine 1.5 mg/ml 4 hrs, larvae L3    23 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    31 Paraquat 10 mM 48 hrs, 4-day adult    34 Rotenone 2 μg 12 hrs, larvae L3    33 Rotenone 8 μg 12 hrs, larvae L3    40 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    5 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3  (39) Cadmium 50 mM 12 hrs, larvae L3  (31) Cadmium 50 mM 48 hrs, 4-day adult    17 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3    20 Ethanol 5% 3 hrs, larvae L3  (35) Ethanol 10% 3 hrs, larvae L3    24 Caffeine 1.5 mg/ml 4 hrs, larvae L3    23 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult  (31) Paraquat 10 mM 48 hrs, 4-day adult  (34) Rotenone 2 μg 12 hrs, larvae L3  (33) Rotenone 8 μg 12 hrs, larvae L3  (40) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    5 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    39 Cadmium 50 mM 12 hrs, larvae L3    31 Cadmium 50 mM 48 hrs, 4-day adult    17 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3    20 Ethanol 5% 3 hrs, larvae L3    35 Ethanol 10% 3 hrs, larvae L3    24 Caffeine 1.5 mg/ml 4 hrs, larvae L3    23 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    31 Paraquat 10 mM 48 hrs, 4-day adult    34 Rotenone 2 μg 12 hrs, larvae L3    33 Rotenone 8 μg 12 hrs, larvae L3    40 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    5 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    39 Cadmium 50 mM 12 hrs, larvae L3    31 Cadmium 50 mM 48 hrs, 4-day adult    17 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3    20 Ethanol 5% 3 hrs, larvae L3    35 Ethanol 10% 3 hrs, larvae L3    24 Caffeine 1.5 mg/ml 4 hrs, larvae L3    23 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    31 Paraquat 10 mM 48 hrs, 4-day adult    34 Rotenone 2 μg 12 hrs, larvae L3    33 Rotenone 8 μg 12 hrs, larvae L3    40 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    5 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    39 Cadmium 50 mM 12 hrs, larvae L3    31 Cadmium 50 mM 48 hrs, 4-day adult    17 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3    20 Ethanol 5% 3 hrs, larvae L3    35 Ethanol 10% 3 hrs, larvae L3    24 Caffeine 1.5 mg/ml 4 hrs, larvae L3    23 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    31 Paraquat 10 mM 48 hrs, 4-day adult    34 Rotenone 2 μg 12 hrs, larvae L3    33 Rotenone 8 μg 12 hrs, larvae L3    40 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    5 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3  (39) Cadmium 50 mM 12 hrs, larvae L3  31 Cadmium 50 mM 48 hrs, 4-day adult    17 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3    20 Ethanol 5% 3 hrs, larvae L3  (35) Ethanol 10% 3 hrs, larvae L3    24 Caffeine 1.5 mg/ml 4 hrs, larvae L3    23 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult  31 Paraquat 10 mM 48 hrs, 4-day adult  (34) Rotenone 2 μg 12 hrs, larvae L3  (33) Rotenone 8 μg 12 hrs, larvae L3  (40) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    5 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    39 Cadmium 50 mM 12 hrs, larvae L3    31 Cadmium 50 mM 48 hrs, 4-day adult    17 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3    20 Ethanol 5% 3 hrs, larvae L3    35 Ethanol 10% 3 hrs, larvae L3    24 Caffeine 1.5 mg/ml 4 hrs, larvae L3    23 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    31 Paraquat 10 mM 48 hrs, 4-day adult    34 Rotenone 2 μg 12 hrs, larvae L3    33 Rotenone 8 μg 12 hrs, larvae L3    40 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    5 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    39 Cadmium 50 mM 12 hrs, larvae L3    31 Cadmium 50 mM 48 hrs, 4-day adult    17 Cadmium 100 mM 48 hrs, 4-day adult    4 Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    16 Ethanol 2.5% 3 hrs, larvae L3    20 Ethanol 5% 3 hrs, larvae L3    35 Ethanol 10% 3 hrs, larvae L3    24 Caffeine 1.5 mg/ml 4 hrs, larvae L3    23 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    31 Paraquat 10 mM 48 hrs, 4-day adult    34 Rotenone 2 μg 12 hrs, larvae L3    33 Rotenone 8 μg 12 hrs, larvae L3    40 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_04
External Data & Images
Linkouts	BDGP expression data • RH24258 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0027586 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5867-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CG5867GD5377 Phenotype manifest in Allele
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of CG5867 Class Mutagen Stocks Known lesion CG5867MB04780 1 -- CG5867MI07331 0 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG5867 Class Mutagen Stocks Known lesion CG5867GD5377 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes CG5867NIG.5867R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel8029 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD5377} NA P{NIG.5867R} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap binary system Mi{ET1}CG5867MB04780 No miscellaneous insertions Mi{MIC}CG5867MI07331 NA
Gene Ontology: Function, Process & Cellular Component ( 1 unique term )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function ( 0 terms)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
extracellular space inferred from sequence or structural similarity with to (Dauwalder et al., 2002)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
CG5867 - Lmpt anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG5867 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 60766 DroID - A comprehensive database of gene and protein interactions. • FBgn0027586 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34728
Orthologs
OrthoDB Orthologs (31) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6GQQR6 Dipteran inclusive ortholog search EOG6V43HM Insect inclusive ortholog search EOG6Z8WT0 Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG6GQQR6)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\CG5867     Drosophila simulans   Dsim\GD23877 Y   Drosophila sechellia   Dsec\GM10311 Y   Drosophila sechellia   Dsec\GM22927     Drosophila erecta   Dere\GG23828 Y   Drosophila yakuba   Dyak\GE18631 Y   Drosophila ananassae   Dana\GF23097 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA19190 Y   Drosophila persimilis   Dper\GL26314 Y   Drosophila willistoni   Dwil\GK14551 Y   Drosophila virilis   Dvir\GJ17957 Y   Drosophila mojavensis   Dmoj\GI17612 Y   Drosophila grimshawi   Dgri\GH25091 Y
Orthologs in non-Drosophila Dipterans (EOG6V43HM)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL004987 Y Anopheles gambiae Malaria mosquito  Agam\AGAP008182 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ801462 Y
Orthologs in non-Dipteran Insects (EOG6Z8WT0)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH23882 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH23883 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO14566 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO14567 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB11415 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB15040 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB11416 Y Solenopsis invicta Red fire ant  Sinv\SINV23184 Y Solenopsis invicta Red fire ant  Sinv\SINV25302 Y Solenopsis invicta Red fire ant  Sinv\SINV24903 Y Solenopsis invicta Red fire ant  Sinv\SINV23209 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI006788 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI007754 Y Bombyx mori Silkmoth  Bmor\BGIBMGA003736 Y Pediculus humanus Human body louse  Phum\PHUM535270 Y
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD23877 Drosophila sechellia Dsec\GM10311 Drosophila erecta Dere\GG23828 Drosophila yakuba Dyak\GE18631 Drosophila ananassae Dana\GF23097 Drosophila pseudoobscura pseudoobscura Dpse\GA19190 Drosophila persimilis Dper\GL26314 Drosophila willistoni Dwil\GK14551 Drosophila virilis Dvir\GJ17957 Drosophila mojavensis Dmoj\GI17612 Drosophila grimshawi Dgri\GH25091
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
Bloomington	24226 w1118; Mi{ET1}CG5867MB04780
VDRC	v38019 w1118; P{GD5377}v38019 v38020 w1118; P{GD5377}v38020
Genomic Clones ( 1 )
	BACR04E19 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 41 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH05536 RH24258
Other clones	FI02981
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH01463 GH03610 GH07136 GH09443 GH09811 GH11239 GH12523 GH13702 GH19115 GH25536 GH26840 GH26852 GH28638 GM09889 HL02760 RH20707 RH20778 RH22767 RH37055 RH47303 RH54141 RH72842
Other clones	9756 18855 19340 56568 105532 CK01.118B.H4 EK090062 EK108962 EK132262 EK132312 EK164521 EK169037 EK172503 EK230523 EK263109 GH05588
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0027586 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34728
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: BcDNA:GH05536 CG5867 (Guan, 1999.11)
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_135781 RefSeq (Proteins) • NP_609625 DDBJ / EMBL / GenBank • AAD38603 AAF53270 AAL90398 AF145628 AI107709 AI402010 AY089660 BI584924 Entrez Gene - A searchable database of RefSeq genes. • 34728 UniProtKB/TrEMBL • Q8SXF9 Q9Y143
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Haemolymph juvenile hormone binding (IPR010562) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • RH24258
Linkouts
	BioGRID - A database of protein and genetic interactions • 60766 DroID - A comprehensive database of gene and protein interactions. • FBgn0027586 DRSC - Results from RNAi screens. • FBgn0027586 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0027586 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5867-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0027586 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34728 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34728 modMine - Data generated by the modENCODE project. • FBgn0027586
Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	BcDNA:GH05536 (Giot et al., 2003, ) CG5867 (Smith et al., 2011, Dauwalder et al., 2002, Vanaphan et al., 2012, Japanese National Institute of Genetics, 2012.5.21) CT18390 (Ceriani et al., 2002)
Name Synonym
Secondary FlyBase IDs
References ( 17 )
Research paper	Vanaphan et al., 2012, Gene 491(2): 142--148 Diversification of takeout, a male-biased gene family in Drosophila. [FBrf0216815] Baycin-Hizal et al., 2011, J. Proteome Res. 10(6): 2777--2784 GlycoFly: A Database of Drosophila N-linked Glycoproteins Identified Using SPEG-MS Techniques. [FBrf0213834] Smith et al., 2011, Mol. Cell 44(6): 954--965 The little elongation complex regulates small nuclear RNA transcription. [FBrf0217100] Ceriani et al., 2002, J. Neurosci. 22(21): 9305--9319 Genome-wide expression analysis in Drosophila reveals genes controlling circadian behavior. [FBrf0152147] Dauwalder et al., 2002, Genes Dev. 16(22): 2879--2892 The Drosophila takeout gene is regulated by the somatic sex-determination pathway and affects male courtship behavior. [FBrf0152012]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Bellen, 2013.1.8, set1020.xml set1020.xml [FBrf0220461] Mintseris et al., 2009.11.23, DPiM: the Drosophila Protein Interaction Mapping project DPiM: the Drosophila Protein Interaction Mapping project [FBrf0209452] Bellen, 2007.8.20, GDPset753.xml GDPset753.xml [FBrf0200262] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file) Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078]
Stock list	Japanese National Institute of Genetics, 2012.5.21, RNAi stocks available from NIG-FLY. RNAi stocks available from NIG-FLY. [FBrf0218457]
Curated genome annotation	Guan, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126671]