Receptor which is involved in the phagocytosis of a variety of cells including apoptotic cells, severed and pruned axons, degenerating dendrites, salivary gland cells, germline cells and bacteria (
PubMed:15342648,
PubMed:16772168,
PubMed:16772169,
PubMed:18984163,
PubMed:20577216,
PubMed:22992958,
PubMed:24412417). Binds to the ligand prtp which relocates from the endoplasmic reticulum to the cell surface during apoptosis (
PubMed:19927123,
PubMed:23337816). Ligand-binding may promote tyrosine phosphorylation mediated by Src42a, interaction with shark and subsequent activation of phagocytosis (
PubMed:18432193). Also binds to the membrane phospholipid phosphatidylserine which is exposed on the surface of apoptotic cells (
PubMed:23420848). Required for the phagocytosis of apoptotic cells by macrophages (
PubMed:15342648). Also required for the phagocytosis of apoptotic neurons by glial cells in the embryonic nervous system (
PubMed:12765609). Acts downstream of NimC4/simu in the glial phagocytosis of apoptotic neurons (
PubMed:18455990). Plays a role in the glial engulfment of larval axons as part of programmed axon pruning during metamorphosis (
PubMed:16772168,
PubMed:16772170). Also mediates glial cell clearance of severed axons following axonal injury (
PubMed:16772169,
PubMed:27498858). Required for the engulfment of degenerating dendrites by epidermal cells (
PubMed:24412417). Required in the ovary for the engulfment and subsequent processing of dying germline cells by follicular epithelial cells through activation of the JNK/bsk pathway (
PubMed:22992958,
PubMed:27347682). Plays a role in neuromuscular junction development by mediating the clearance of presynaptic debris and immature boutons which are shed by growing synapses (
PubMed:19707574). Required for larval salivary gland cell death which occurs following a rise in steroid levels after puparium formation (
PubMed:20577216). Also involved in bacterial phagocytosis (
PubMed:18984163). Required for hemocyte phagocytosis of the Gram-positive bacterium S.aureus (
PubMed:19890048). Lipoteichoic acid, synthesized by the S.aureus lipoteichoic acid synthase ltaS, acts as a ligand for drpr in this process (
PubMed:19890048). Together with Src42a and shark, promotes the migration of macrophages to sites of wounding as part of a signaling cascade where Scr42a detects production of hydrogen peroxide at wound sites which triggers phosphorylation of drpr and subsequent recruitment and activation of shark (
PubMed:26028435). Also required for macrophage priming which occurs following phagocytosis of apoptotic cells and ensures that macrophages develop a form of molecular memory that allows them to later mount an inflammatory response to tissue damage and bacterial infection (
PubMed:27212238). Is also an essential factor in the regulation of muscle development and myogenesis, and as a consequence is required for normal locomotion (
PubMed:12765609,
PubMed:25111228, Ref.27). Likely to control the balance between skeletal muscle satellite cells proliferation and differentiation through regulation of the notch signaling pathway (
PubMed:25111228,
PubMed:30802937, Ref.27).
Isoform B: Promotes engulfment of axonal debris by glial cells following axonal injury.
Isoform A: Potently inhibits glial cell engulfment of axonal debris produced following axonal injury.
