FlyBase Gene Report: Dmel\drpr

General Information

Symbol

Dmel\drpr

Species

D. melanogaster

Name

draper

Annotation Symbol

CG2086

Feature Type

protein_coding_gene

FlyBase ID

FBgn0027594

Gene Model Status

Current

Stock Availability

15 publicly available

Gene Snapshot

draper (drpr) encodes a single-pass transmembrane receptor that is involved in phagocytosis by glia, macrophages, and epithelia. It signals downstream through the proteins encoded by Src42A and Shark to promote Rac1 function and transcriptional changes through the products of Jra and Stat92E. It is also required for activation of autophagy in salivary glands. [Date last reviewed: 2019-03-21]

Other Summaries

Alliance
Auto summary
UniProtKB
Interactive Fly

Also Known As

BcDNA:GH03529

Key Links

Genomic Location

Cytogenetic map

62B1-62B1

Sequence location

3L:1,715,595..1,731,107 [-]

Recombination map

3-1.0

RefSeq locus

NT_037436 REGION:1715595..1731107

Sequence

Get Decorated FASTA

Genomic Maps

GBrowse JBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

[Detailed GO annotations]

Protein Family (UniProt)

Belongs to the MEGF family. (Q9W0A0)

Protein Signatures (InterPro)

Molecular Function (GO)
[Detailed GO annotations]

Experimental Evidence

phosphatidylserine binding; protein binding

Predictions / Assertions

Summaries

Protein Function (UniProtKB)

Receptor which is involved in the phagocytosis of a variety of cells including apoptotic cells, severed and pruned axons, degenerating dendrites, salivary gland cells, germline cells and bacteria (PubMed:15342648, PubMed:16772168, PubMed:16772169, PubMed:18984163, PubMed:20577216, PubMed:22992958, PubMed:24412417). Binds to the ligand prtp which relocates from the endoplasmic reticulum to the cell surface during apoptosis (PubMed:19927123, PubMed:23337816). Ligand-binding may promote tyrosine phosphorylation mediated by Src42a, interaction with shark and subsequent activation of phagocytosis (PubMed:18432193). Also binds to the membrane phospholipid phosphatidylserine which is exposed on the surface of apoptotic cells (PubMed:23420848). Required for the phagocytosis of apoptotic cells by macrophages (PubMed:15342648). Also required for the phagocytosis of apoptotic neurons by glial cells in the embryonic nervous system (PubMed:12765609). Acts downstream of NimC4/simu in the glial phagocytosis of apoptotic neurons (PubMed:18455990). Plays a role in the glial engulfment of larval axons as part of programmed axon pruning during metamorphosis (PubMed:16772168, PubMed:16772170). Also mediates glial cell clearance of severed axons following axonal injury (PubMed:16772169, PubMed:27498858). Required for the engulfment of degenerating dendrites by epidermal cells (PubMed:24412417). Required in the ovary for the engulfment and subsequent processing of dying germline cells by follicular epithelial cells through activation of the JNK/bsk pathway (PubMed:22992958, PubMed:27347682). Plays a role in neuromuscular junction development by mediating the clearance of presynaptic debris and immature boutons which are shed by growing synapses (PubMed:19707574). Required for larval salivary gland cell death which occurs following a rise in steroid levels after puparium formation (PubMed:20577216). Also involved in bacterial phagocytosis (PubMed:18984163). Required for hemocyte phagocytosis of the Gram-positive bacterium S.aureus (PubMed:19890048). Lipoteichoic acid, synthesized by the S.aureus lipoteichoic acid synthase ltaS, acts as a ligand for drpr in this process (PubMed:19890048). Together with Src42a and shark, promotes the migration of macrophages to sites of wounding as part of a signaling cascade where Scr42a detects production of hydrogen peroxide at wound sites which triggers phosphorylation of drpr and subsequent recruitment and activation of shark (PubMed:26028435). Also required for macrophage priming which occurs following phagocytosis of apoptotic cells and ensures that macrophages develop a form of molecular memory that allows them to later mount an inflammatory response to tissue damage and bacterial infection (PubMed:27212238). Is also an essential factor in the regulation of muscle development and myogenesis, and as a consequence is required for normal locomotion (PubMed:12765609, PubMed:25111228, Ref.27). Likely to control the balance between skeletal muscle satellite cells proliferation and differentiation through regulation of the notch signaling pathway (PubMed:25111228, PubMed:30802937, Ref.27). Isoform B: Promotes engulfment of axonal debris by glial cells following axonal injury. Isoform A: Potently inhibits glial cell engulfment of axonal debris produced following axonal injury.

(UniProt, Q9W0A0)

Summary (Interactive Fly)

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the GBrowse view of Dmel\drpr or the JBrowse view of Dmel\drpr for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.41

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

drpr-RA

FBtr0072798

NM_058102

3206

594

drpr-RB

FBtr0072799

NM_167911

4517

1031

drpr-RC

FBtr0309845

NM_001259620

3298

528

drpr-RD

FBtr0334078

NM_001274346

3148

613

drpr-RE

FBtr0334079

NM_001274347

4435

1042

drpr-RF

FBtr0334080

NM_001274348

4757

976

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

drpr-PA

FBpp0072680

66.2

594

6.51

NP_477450

AAF47552

drpr-PB

FBpp0072681

113.0

1031

5.96

NP_728660

AAF47553

drpr-PC

FBpp0301579

58.7

528

6.69

NP_001246549

AFH04220

drpr-PD

FBpp0306203

68.3

613

6.48

NP_001261275

AGB93970

drpr-PE

FBpp0306204

114.3

1042

6.01

NP_001261276

AGB93971

drpr-PF

FBpp0306205

106.8

976

6.10

NP_001261277

AGB93972

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Subunit Structure (UniProtKB)

Interacts (via the cytoplasmic domain) with shark; this is required for the recruitment of drpr and glial cells to severed axons and for the phagocytosis of axonal debris by glial cells following axon injury (PubMed:18432193). Interacts with ced-6 (PubMed:16772168). Isoform A: Interacts with csw; this results in dephosphorylation of drpr isoform A which is required for the inhibition of glial cell engulfment of axonal debris produced following axonal injury (PubMed:22426252).

(UniProt, Q9W0A0)

Post Translational Modification

Phosphorylated on tyrosine residues (PubMed:18432193, PubMed:19927123, PubMed:23337816, PubMed:23420848). Phosphorylation is induced by binding to prtp (PubMed:19927123). It is also induced by binding to the membrane phospholipid phosphatidylserine (PubMed:23420848). Phosphorylation may be mediated directly or indirectly by Src42a and is required for interaction with shark (PubMed:18432193).

Isoform A: Dephosphorylated by csw which is required for the inhibition of glial cell engulfment of axonal debris produced following axonal injury.

(UniProt, Q9W0A0)

Domain

Isoform B: The intracellular domain is required for glial engulfment activity. Isoform A: The intracellular domain contains an 11-residue insertion compared to isoform B and is incapable of promoting glial engulfment.

(UniProt, Q9W0A0)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\drpr using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

drpr_1

Linkouts

Gene Ontology (20 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

phosphatidylserine binding

inferred from direct assay

(Tung et al., 2013)

protein binding

inferred from physical interaction with UniProtKB:Q7JUY7

(assigned by UniProt )

(Awasaki et al., 2006)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (13 terms)

Terms Based on Experimental Evidence (13 terms)

CV Term

Evidence

References

apoptotic cell clearance

inferred from mutant phenotype

(Doherty et al., 2009, Kurant et al., 2008, Ziegenfuss et al., 2008)

cell competition in a multicellular organism

inferred from mutant phenotype

(Li and Baker, 2007)

defense response to bacterium

inferred from mutant phenotype

(Hashimoto et al., 2009)

engulfment of apoptotic cell

inferred from mutant phenotype

(Etchegaray et al., 2012)

larval locomotory behavior

inferred from mutant phenotype

(Freeman et al., 2003)

neuron remodeling

inferred from mutant phenotype

(Awasaki et al., 2006)

inferred from mutant phenotype

(assigned by UniProt )

(Hoopfer et al., 2006)

phagocytosis

inferred from mutant phenotype

(Hashimoto et al., 2009, Manaka et al., 2004)

phagocytosis, engulfment

inferred from mutant phenotype

(Tasdemir-Yilmaz and Freeman, 2014, Logan et al., 2012)

positive regulation of phagocytosis, engulfment

inferred from mutant phenotype

(Han et al., 2014)

regulation of neuromuscular junction development

inferred from mutant phenotype

(assigned by UniProt )

(Fuentes-Medel et al., 2009)

response to axon injury

inferred from mutant phenotype

(assigned by UniProt )

(MacDonald et al., 2006)

inferred from mutant phenotype

(Neukomm et al., 2014)

salivary gland cell autophagic cell death

inferred from mutant phenotype

(McPhee et al., 2010)

wing disc dorsal/ventral pattern formation

inferred from genetic interaction with FLYBASE:Bx; FB:FBgn0265598, FLYBASE:ap; FB:FBgn0267978

(Bejarano et al., 2008)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

phagocytosis

traceable author statement

(Evans et al., 2003)

Cellular Component (5 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

axon

inferred from mutant phenotype

(assigned by UniProt )

(MacDonald et al., 2006)

cytoplasm

inferred from direct assay

(assigned by UniProt )

(Etchegaray et al., 2012)

plasma membrane

inferred from direct assay

(assigned by UniProt )

(Etchegaray et al., 2012, Freeman et al., 2003)

postsynapse

inferred from mutant phenotype

(assigned by UniProt )

(Fuentes-Medel et al., 2009)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

intrinsic component of membrane

non-traceable author statement

(Manaka et al., 2004)

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

expression microarray

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult fat body

Comment: cyclical, peak ZT13-16

(Xu et al., 2011)

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 11 -- 15

macrophage

(Weavers et al., 2016)

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

third instar larval stage

glial cell | subset of brain | faint

(Awasaki et al., 2006)

prepupal stage P3

glial cell | subset of brain

Comment: 6h APF

(Awasaki et al., 2006)

prepupal stage P4(ii)

glial cell | subset of brain | faint

Comment: 12h APF

(Awasaki et al., 2006)

Additional Descriptive Data

Naive stage 11 macrophages have low levels of drpr transcripts and protein that increase after corpse uptake.

(Weavers et al., 2016)

Expressed cyclically in the adult fat body.

(Xu et al., 2011)

drpr transcript is detected in a subset of glial cells that surround the distal tip of the mushroom body vertical lobes.

(Awasaki et al., 2006)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

prepupal stage P3

glial cell | subset of brain

Comment: 6h APF

(Awasaki et al., 2006)

mushroom body vertical lobe | restricted

Comment: 6h APF

(Awasaki et al., 2006)

adult stage

glial cell of adult brain

(MacDonald et al., 2006)

glial cell of adult antennal lobe

(MacDonald et al., 2006)

adult cell body glial cell of adult antennal lobe

Comment: up-regulated in response to axotomy

(Doherty et al., 2014, Doherty et al., 2009)

adult ensheathing neuropil associated glial cell of adult antennal lobe

(Doherty et al., 2009)

adult ensheathing neuropil associated glial cell

(Doherty et al., 2014)

adult cell body glial cell

(Doherty et al., 2014)

oogenesis

follicle cell | subset

Comment: in dying egg chambers

(Etchegaray et al., 2012)

prepupal stage P3 -- P4

embryonic/larval salivary gland

(McPhee et al., 2010)

prepupal stage P2 -- P3

reticular neuropil associated glial cell of neuropil

(Tasdemir-Yilmaz and Freeman, 2014)

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 11 -- 15

macrophage

(Weavers et al., 2016)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

western blot

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult brain

(Doherty et al., 2014)

Additional Descriptive Data

Naive stage 11 macrophages have low levels of drpr transcripts and protein that increase after corpse uptake.

(Weavers et al., 2016)

drpr protein is expressed in the follicle cells of dying egg chambers. drpr protein levels increase in follicle cells as engulfment of nurse cells by follicle cells in dying egg chambers proceeds.

(Etchegaray et al., 2012)

Some drpr isoforms are present at low levels in salivary glands and localize to the luminal/apical region at 6h APF. Following the rise in steroid levels that triggers cell death at 12h APF, drpr levels increase and remain high up to 14h APF, when some of the drpr changes from an apical to a cytoplasmic localization.

(McPhee et al., 2010)

drpr protein is detected in a subset of glial cells that surround the distal tip of the mushroom body vertical lobes. These cells also express ced-6 protein. Expression in also detected in glial processes that infiltrate the vertical lobes.

(Awasaki et al., 2006)

Marker for

Subcellular Localization

CV Term

Evidence

References

axon

inferred from mutant phenotype

(assigned by UniProt )

(MacDonald et al., 2006)

cytoplasm

inferred from direct assay

(assigned by UniProt )

(Etchegaray et al., 2012)

plasma membrane

inferred from direct assay

(assigned by UniProt )

(Etchegaray et al., 2012, Freeman et al., 2003)

postsynapse

inferred from mutant phenotype

(assigned by UniProt )

(Fuentes-Medel et al., 2009)

Expression Deduced from Reporters

Reporter: P{drpr-GAL4.ee7.MUT}

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult cell body glial cell

Comment: up-regulated in response to axotomy

(Doherty et al., 2014)

adult cell body glial cell of adult antennal lobe

Comment: up-regulated in response to axotomy

(Doherty et al., 2014)

reticular neuropil associated glial cell | faint

(Doherty et al., 2014)

adult ensheathing neuropil associated glial cell

Comment: up-regulated in response to axotomy

(Doherty et al., 2014)

Reporter: P{drpr-GAL4.ee7}

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult cell body glial cell

Comment: up-regulated in response to axotomy

(Doherty et al., 2014)

adult cell body glial cell of adult antennal lobe

Comment: up-regulated in response to axotomy

(Doherty et al., 2014)

reticular neuropil associated glial cell | faint

(Doherty et al., 2014)

adult ensheathing neuropil associated glial cell

Comment: up-regulated in response to axotomy

(Doherty et al., 2014)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\drpr in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\drpr

View exonic expression by tissue for Dmel\drpr

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0027594

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0027594

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG2086-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG2086

Flygut - An atlas of the Drosophila adult midgut

FBgn0027594

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\drpr

Stages(s) 1-3
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 18 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 21 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of drpr

Transgenic constructs containing regulatory region of drpr

Deletions and Duplications ( 1 )

Partially disrupted in

Df(3L)drpr^Δ5

(Draper et al., 2014)

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal - all die before end of larval stage, with Scer\GAL4^- :

drpr^EP522

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^pnr-MD237

viable, with Scer\GAL4^tin.CΔ4

Other Phenotypes

Allele

cell death defective | adult stage | germline clone | nutrition conditional

drpr^Δ5

cell death defective | adult stage | nutrition conditional

drpr^Δ5

cell death defective | adult stage | nutrition conditional, with Scer\GAL4^GR1

drpr^dsRNA.UAS

immune response defective | conditional

drpr^Δ5

increased cell death | adult stage, with Scer\GAL4^GR1

drpr^I.UAS

locomotor behavior defective | adult stage, with Scer\GAL4^Act5C.PI

drpr^GD14423

locomotor behavior defective | adult stage, with Scer\GAL4^how-24B

drpr^GD14423

locomotor behavior defective | adult stage, with Scer\GAL4^twi.PG

drpr^GD14423

locomotor behavior defective | adult stage | progressive | recessive

drpr^Δ5

locomotor behavior defective | larval stage, with Scer\GAL4^- :

drpr^EP522

neuroanatomy defective

drpr^Δ5

neuroanatomy defective, with Scer\GAL4^alrm.PD

drpr^dsRNA.UAS

neuroanatomy defective, with Scer\GAL4^repo.PU

drpr^dsRNA.UAS

neuroanatomy defective | adult stage

drpr^Δ5

neuroanatomy defective | conditional, with Scer\GAL4^Gli-rL82

drpr^dsRNA.UAS

neuroanatomy defective | conditional, with Scer\GAL4^nrv2.PS

drpr^dsRNA.UAS

neuroanatomy defective | conditional, with Scer\GAL4^repo

drpr^dsRNA.UAS

neuroanatomy defective | conditional, with Scer\GAL4^VGlut-OK371

drpr^Δ5

neuroanatomy defective | larval stage | conditional, with Scer\GAL4^A58

drpr^GD2628

neuroanatomy defective | larval stage | conditional (with Df(3L)BSC181)

drpr^Δ5

neuroanatomy defective | P-stage, with Scer\GAL4^repo

drpr^{dsRNA.UAS.cAa}

neuroanatomy defective | pupal stage

drpr^Δ5

neuroanatomy defective | pupal stage, with Scer\GAL4^en-e16E

drpr^GD2628

neuroanatomy defective | pupal stage (with Df(3L)BSC181)

drpr^Δ5

short lived | recessive

drpr^Δ5

some die during larval stage, with Scer\GAL4^- :

drpr^EP522

uncoordinated | larval stage, with Scer\GAL4^- :

drpr^EP522

Phenotype manifest in

Allele

adult brain

drpr^Δ5

adult brain, with Scer\GAL4^Act5C.PI

drpr^GD14423

adult ensheathing neuropil associated glial cell, with Scer\GAL4^Mz709

drpr^dsRNA.UAS

adult ensheathing neuropil associated glial cell, with Scer\GAL4^repo.PU

drpr^dsRNA.UAS

adult mushroom body

drpr^Δ5

adult olfactory receptor neuron

drpr^Δ5

adult olfactory receptor neuron, with Scer\GAL4^repo.PU

drpr^dsRNA.UAS

dendrite

drpr^Δ5

egg chamber

drpr^Δ5

egg chamber | germline clone | nutrition conditional

drpr^Δ5

egg chamber | nutrition conditional

drpr^Δ5

egg chamber | nutrition conditional, with Scer\GAL4^GR1

drpr^dsRNA.UAS

embryonic/larval salivary gland

drpr^Δ5

embryonic/larval salivary gland, with Scer\GAL4^fkh.PH

embryonic hemocyte

drpr^Δ5

follicle cell | nutrition conditional

drpr^Δ5

follicle cell | nutrition conditional, with Scer\GAL4^GR1

drpr^dsRNA.UAS

gamma Kenyon cell

drpr^Δ5

gamma Kenyon cell, with Scer\GAL4^alrm.PD

drpr^dsRNA.UAS

gamma Kenyon cell | pupal stage

drpr^Δ5

glial cell

drpr^Δ5

glial cell, with Scer\GAL4^repo

drpr^{dsRNA.UAS.cAa}

larval dorsal multidendritic neuron ddaC

drpr^Δ5

larval dorsal multidendritic neuron ddaC | larval stage | conditional, with Scer\GAL4^A58

drpr^GD2628

larval dorsal multidendritic neuron ddaC | larval stage | conditional (with Df(3L)BSC181)

drpr^Δ5

larval dorsal multidendritic neuron ddaC | pupal stage, with Scer\GAL4^en-e16E

drpr^GD2628

larval dorsal multidendritic neuron ddaC | pupal stage (with Df(3L)BSC181)

drpr^Δ5

lysosome, with Scer\GAL4^fkh.PH

drpr^dsRNA.UAS

mesothoracic extracoxal depressor muscle 66

drpr^Δ5

mesothoracic extracoxal depressor muscle 66, with Scer\GAL4^Act5C.PI

drpr^GD14423

nurse cell

drpr^Δ5

nurse cell, with Scer\GAL4^GR1

drpr^I.UAS

reticular neuropil associated glial cell

drpr^Δ5

reticular neuropil associated glial cell, with Scer\GAL4^alrm.PD

drpr^dsRNA.UAS

retina

drpr^Δ5

wing vein L1 | conditional, with Scer\GAL4^Gli-rL82

drpr^dsRNA.UAS

wing vein L1 | conditional, with Scer\GAL4^nrv2.PS

drpr^dsRNA.UAS

wing vein L1 | conditional, with Scer\GAL4^repo

drpr^dsRNA.UAS

wing vein L1 | conditional, with Scer\GAL4^VGlut-OK371

drpr^Δ5

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v7.1)

Homo sapiens (Human) (30)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\MEGF10

13 of 15

Yes

Hsap\MEGF11

11 of 15

Yes

Hsap\PEAR1

8 of 15

Yes

Hsap\MEGF6

3 of 15

Yes

Hsap\CRB2

1 of 15

Hsap\CSF1R

1 of 15

Hsap\DKK2

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Hsap\KDR

1 of 15

Hsap\KIT

1 of 15

Hsap\MSANTD3-TMEFF1

1 of 15

Yes

Hsap\PDGFRA

1 of 15

Hsap\PDGFRB

1 of 15

Hsap\PDGFRL

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Hsap\TNFAIP6

1 of 15

Yes

Model Organism Orthologs (via DIOPT v7.1)

Mus musculus (laboratory mouse) (32)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Megf11

13 of 15

Yes

Mmus\Megf10

12 of 15

Yes

Mmus\Pear1

9 of 15

Yes

Mmus\Megf6

3 of 15

Yes

Mmus\Csf1r

1 of 15

Mmus\Dkk2

1 of 15

Yes

Mmus\Dkk3

1 of 15

Yes

Mmus\Egfem1

1 of 15

Yes

Mmus\Esm1

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Mmus\Ret

1 of 15

Mmus\Scarf1

1 of 15

Mmus\Stab1

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Mmus\Tmeff2

1 of 15

Yes

Mmus\Tnfaip6

1 of 15

Yes

Rattus norvegicus (Norway rat) (29)

Rnor\Megf11

12 of 13

Yes

Rnor\Megf10

11 of 13

Yes

Rnor\Pear1

6 of 13

Yes

Rnor\LOC100911486

2 of 13

Yes

Rnor\Csf1r

1 of 13

Rnor\Dkk2

1 of 13

Yes

Rnor\Esm1

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Rnor\Kdr

1 of 13

Rnor\Kit

1 of 13

Rnor\Megf6

1 of 13

Yes

Rnor\Pdgfra

1 of 13

Rnor\Pdgfrb

1 of 13

Rnor\Pdgfrl

1 of 13

Yes

Rnor\Ret

1 of 13

Rnor\Scarf2

1 of 13

Rnor\Stab1

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Rnor\Tnfaip6

1 of 13

Yes

Xenopus tropicalis (Western clawed frog) (21)

Xtro\megf11

7 of 12

Yes

Xtro\megf10

6 of 12

Yes

Xtro\pear1

3 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Xtro\pdgfrl

1 of 12

Yes

Xtro\ret

1 of 12

Xtro\stab2

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Danio rerio (Zebrafish) (42)

Drer\megf11

13 of 15

Yes

Drer\pear1

10 of 15

Yes

Drer\megf10

8 of 15

Yes

Drer\megf6b

3 of 15

Yes

Drer\zgc:158328

3 of 15

Yes

Drer\megf6a

2 of 15

Yes

Drer\ccbe1

1 of 15

Yes

Drer\csf1ra

1 of 15

Drer\csf1rb

1 of 15

Drer\dkk1a

1 of 15

Yes

Drer\dkk2

1 of 15

Yes

Drer\esm1

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Drer\ret

1 of 15

Drer\scarf1

1 of 15

Drer\si:ch73-206d17.1

1 of 15

Drer\si:ch211-167j9.5

1 of 15

Yes

Drer\si:dkey-1j5.4

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Drer\tmeff1b

1 of 15

Yes

Drer\tmeff2a

1 of 15

Yes

Drer\tnfaip6

1 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (46)

Cele\ced-1

13 of 15

Yes

Cele\Y64G10A.7

4 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Cele\dsl-2

1 of 15

Yes

Cele\dsl-3

1 of 15

Yes

Cele\dsl-5

1 of 15

Yes

Cele\dsl-6

1 of 15

Yes

Cele\dsl-7

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Cele\F46B3.15

1 of 15

Yes

Cele\F59F5.3

1 of 15

Cele\far-5

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Cele\str-90

1 of 15

Yes

Cele\T01G5.1

1 of 15

Cele\T12A7.2

1 of 15

Yes

Cele\T17A3.10

1 of 15

Yes

Cele\T25F10.3

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Cele\W04G5.10

1 of 15

Cele\Y38H6C.20

1 of 15

Cele\Y41D4B.26

1 of 15

Yes

Cele\Y50D4B.6

1 of 15

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091900Y7 )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila melanogaster

fruit fly

Dmel\drpr

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA23962

Drosophila persimilis

Dper\GL11918

Drosophila willistoni

Dwil\GK17064

Drosophila virilis

Dvir\GJ12529

Drosophila mojavensis

Dmoj\GI16787

Drosophila grimshawi

Dgri\GH15511

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500O6 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17021923

Glossina morsitans

Tsetse fly

Gmor\GMOY009946

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_13493

Mayetiola destructor

Hessian fly

Mdes\Mdes004844

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL008198

Anopheles darlingi

American malaria mosquito

Adar\ADAC008908

Anopheles gambiae

Malaria mosquito

Agam\AGAP007256

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ002121

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W05IV )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA012538

Danaus plexippus

Monarch butterfly

Dple\DPOGS208973-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL002647

Apis florea

Little honeybee

Aflo\2530298356

Apis mellifera

Western honey bee

Amel\GB54664

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP21452

Bombus terrestris

Buff-tailed bumblebee

Bter\15211163

Linepithema humile

Argentine ant

Lhum\LH12096

Linepithema humile

Argentine ant

Lhum\LH12097

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:002d21

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:002d22

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG003412

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_00482

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_00301

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_05454

Tribolium castaneum

Red flour beetle

Tcas\drpr

Pediculus humanus

Human body louse

Phum\PHUM049590

Rhodnius prolixus

Kissing bug

Rpro\RPRC002422

Cimex lectularius

Bed bug

Clec\CLEC004060

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI001685

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_06222

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X05F0 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR000981

Strigamia maritima

European centipede

Smar\SMAR004984

Ixodes scapularis

Black-legged tick

Isca\ISCW020553

Ixodes scapularis

Black-legged tick

Isca\ISCW024127

Stegodyphus mimosarum

African social velvet spider

Smim\KFM78730.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM78731.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM77793.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM71170.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM61145.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur08g04300

Tetranychus urticae

Two-spotted spider mite

Turt\tetur04g05840

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_47122

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G00XN )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Megf6

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-EMI/Egf

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Megf11_2

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Megf6_4

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Megf6-2

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Hypp_2282

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Megf6L

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Megf11

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Megf6-3

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000002306

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000007631

Gallus gallus

Domestic chicken

Ggal\MEGF10

Gallus gallus

Domestic chicken

Ggal\LOC424998

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000028622

Gallus gallus

Domestic chicken

Ggal\MEGF6

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v7.1)

Drosophila melanogaster (Fruit fly) (22)

Gene Symbol

Score

Source

Alignment

2 of 10

btl

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

htl

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

Pvr

1 of 10

Ret

1 of 10

Tie

1 of 10

tor

1 of 10

Wsck

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

myopathy, areflexia, respiratory distress, and dysphagia, early-onset

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 2 )

Allele

Disease

Evidence

References

drpr^Δ5

model of myopathy

CEA

(Draper et al., 2014)

drpr^GD14423

model of myopathy

CEA

(Draper et al., 2014)

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

MEGF10; multiple EGF like domains 10

model of early-onset myopathy-areflexia-respiratory distress-dysphagia syndrome

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

MEGF10; multiple EGF like domains 10

13 of 15

612453

MYOPATHY, AREFLEXIA, RESPIRATORY DISTRESS, AND DYSPHAGIA, EARLY-ONSET; EMARDD

early-onset myopathy-areflexia-respiratory distress-dysphagia syndrome

MEGF11; multiple EGF like domains 11

11 of 15

612454

PEAR1; platelet endothelial aggregation receptor 1

8 of 15

610278

MEGF6; multiple EGF like domains 6

3 of 15

604266

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

drpr - CaBP1

affinity chromatography technology, Identification by mass spectrometry, solid phase assay, identification by antibody

(Okada et al., 2012)

drpr - Shark

anti bait coimmunoprecipitation, anti tag western blot, anti tag coimmunoprecipitation, two hybrid, fluorescent resonance energy transfer, fluorescence technology

(Williamson and Vale, 2018, Lu et al., 2017, Logan et al., 2012, Ziegenfuss et al., 2008)

drpr - Traf4

anti tag coimmunoprecipitation, anti tag western blot

(Lu et al., 2017)

drpr - ced-6

pull down, western blot

(Awasaki et al., 2006)

drpr - csw

anti bait coimmunoprecipitation, anti tag western blot

(Logan et al., 2012)

drpr - prtp

pull down, anti tag western blot, western blot, peptide massfingerprinting

(Fujita et al., 2012, Kuraishi et al., 2009)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

drpr

suppressible

Atg1

(McPhee et al., 2010)

drpr

enhanceable

Ced-12

(Tasdemir-Yilmaz and Freeman, 2014)

drpr

enhanceable

Crk

(Tasdemir-Yilmaz and Freeman, 2014)

drpr

suppressible

hep

(Etchegaray et al., 2012)

drpr

enhanceable

Itgbn

(Nagaosa et al., 2011)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

drpr

(Bejarano et al., 2008)

Bx|ap

suppressible

drpr

(Bejarano et al., 2008)

CDC50

suppressible

drpr

(Sapar et al., 2018)

ced-6

enhanceable

drpr

(Awasaki et al., 2006)

Itgbn

enhanceable

drpr

(Nagaosa et al., 2011)

repo

suppressible

NimC4|drpr

(Shklyar et al., 2014)

External Data

Subunit Structure (UniProtKB)

(UniProt, Q9W0A0 )

Linkouts

BioGRID - A database of protein and genetic interactions.

63751

DroID - A comprehensive database of gene and protein interactions.

FBgn0027594

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

38218

MIST (protein-protein) - An integrated Molecular Interaction Database

drpr

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-1.0

Cytogenetic map

62B1-62B1

Sequence location

3L:1,715,595..1,731,107 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

62B1-62B1

Limits computationally determined from genome sequence between P{EP}rho^EP3704&P{PZ}l(3)06226⁰⁶²²⁶ and P{PZ}dlt⁰⁴²⁷⁶

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-1.0

(FlyBase, 2016)

3-2.7

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (15)

Bloomington

67037

w^*; P{UAS-drpr.III}2

67035

y¹ w^*; P{UAS-drpr.I}2

67036

y¹ w^*; P{UAS-drpr.II}2

22010

w¹¹¹⁸; P{EPg}drpr^HP37013

25531

w¹¹¹⁸; Mi{ET1}drpr^MB06916

67034

y¹ w^*; P{UAS-drpr.dsRNA}2/CyO

43909

y¹ w^*; Mi{MIC}drpr^MI07659

53129

y¹ w^*; Mi{MIC}drpr^MI09543

VDRC

v4833

w¹¹¹⁸; P{GD2628}v4833

v27086

w¹¹¹⁸; P{GD14423}v27086

v4830

w¹¹¹⁸; P{GD2628}v4830/TM3

v27084

w¹¹¹⁸; P{GD14423}v27084/TM3

More stocks available...

Genomic Clones (25)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (73)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequences

BDGP DGC clones

Other clones

FI03750

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0027594

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0027594

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

38218

Antibody Information

Laboratory Generated Antibodies

monoclonal

(Musashe et al., 2016)

Commercially Available Antibodies

Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: BcDNA:GH03529 CG2086

(Deng, 1999.11)

Source for identity of: drpr BcDNA:GH03529

(Freeman, 2002.3.5, Freeman et al., 2001)

Source for database merge of

Source for merge of: drpr CG18172

(FlyBase Genome Annotators, 2002-2003)

Additional comments

Other Comments

Isoform I of drpr, but not isoforms II or III, is sufficient for glial phagocytic engulfment of degenerating axons in the adult brain.

(Logan et al., 2012)

The drpr-II isoform inhibits glial phagocytic engulfment of degenerating axons through an ITIM-like domain.

(Logan et al., 2012)

drp is required for degradation of apoptotic cells after they have been engulfed during apoptotic cell clearance by glia in the nervous system and macrophages elsewhere.

(Kurant et al., 2008)

drpr is needed in wild-type cells for the death of Minute neighbours in cell competition experiments.

(Li and Baker, 2007)

In drpr mutants glia fail to respond morphologically to axon injury, and severed axons are not cleared from the CNS.

(MacDonald et al., 2006)

drpr is involved in the phagocytosis of apoptotic cells by hemocytes/macrophages.

(Manaka et al., 2004)

Identification: by computational analysis looking for genes flanking gcm binding sites.

(Freeman et al., 2001)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 63 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

38218

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9W0A0

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0027594

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0027594

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

drpr_1

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG2086

Flygut - An atlas of the Drosophila adult midgut

FBgn0027594

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

38218

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC000689

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG2086

modMine - A data warehouse for the modENCODE project

FBgn0027594

Linkouts

BioGRID - A database of protein and genetic interactions.

63751

DroID - A comprehensive database of gene and protein interactions.

FBgn0027594

DRSC - Results frm RNAi screens

FBgn0027594

Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0027594

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG2086-RA

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0027594

FlyMine - An integrated database for Drosophila genomics

FBgn0027594

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

38218

MIST (protein-protein) - An integrated Molecular Interaction Database

drpr

Synonyms and Secondary IDs (11)

Reported As

Symbol Synonym

BcDNA:GH03529

(Egger et al., 2002)

CG18172

(Freeman, 2002.3.5)

CG2086

(Ni et al., 2011.7.19, Piacentini et al., 2009, Kurucz et al., 2007, Qin et al., 2005)

CT41022

(Hynes and Zhao, 2000)

CT6730

(Hynes and Zhao, 2000)

DRPR

(Chorna and Hasan, 2012)

Draper

(Ekowati et al., 2017, Nainu et al., 2017, Wood and Martin, 2017, Péan and Dionne, 2014, Fang and Bonini, 2012)

Draper I

(Freeman, 2015)

Drpr

(Etchegaray et al., 2012, Shen and Codogno, 2011, Fuentes-Medel et al., 2009)

draper

(Musashe et al., 2016, Levayer and Moreno, 2013, Kurant, 2011, Somogyi et al., 2010, Williams et al., 2006)

drpr

(Asri et al., 2019, Banerjee et al., 2019, Engel et al., 2019, Melcarne et al., 2019, Nakano et al., 2019, Saha et al., 2019, Sapar and Han, 2019, Yang and Chien, 2019, Santoso et al., 2018, Shlyakhover et al., 2018, Fochler et al., 2017, Lu et al., 2017, Ray et al., 2017, Okuda et al., 2016, Weavers et al., 2016, Gene Disruption Project members, 2015-, Nainu et al., 2015, Ashwal-Fluss et al., 2014, Doherty et al., 2014, Draper et al., 2014, Han et al., 2014, Neukomm et al., 2014, Shklyar et al., 2014, Tasdemir-Yilmaz and Freeman, 2014, Lavagnino et al., 2013, Tung et al., 2013, Etchegaray et al., 2012, Fujita et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Logan et al., 2012, Okada et al., 2012, Shiratsuchi et al., 2012, Gafuik and Steller, 2011, Nagaosa et al., 2011, Xu et al., 2011, McPhee et al., 2010, Thomson and Johnson, 2010, Kuraishi et al., 2009, Martín et al., 2009, Cuttell et al., 2008, Kurant et al., 2008, Hueber et al., 2007, Kuraishi et al., 2007, Li and Baker, 2007, Zhang et al., 2007, Awasaki et al., 2006, Hoopfer et al., 2006)

Name Synonyms

Draper

(Lu et al., 2020, Kounatidis and Chtarbanova, 2018, Losada-Perez, 2018, Williamson and Vale, 2018, Kutscher and Shaham, 2017, Lu et al., 2017, Purice et al., 2017, Meehan et al., 2016, Parsons and Foley, 2016, Purice et al., 2016, Weavers et al., 2016, Erdmann et al., 2015, Lee and Sun, 2015, Pearce et al., 2015, Stratoulias and Heino, 2015, Vlisidou and Wood, 2015, Amoyel and Bach, 2014, Doherty et al., 2014, Han et al., 2014, Lu et al., 2014, Wang et al., 2014, Corty and Freeman, 2013, Jenkins et al., 2013, Levayer and Moreno, 2013, Macdonald et al., 2013, Etchegaray et al., 2012, Fujita et al., 2012, Igboin et al., 2012, Kounatidis and Ligoxygakis, 2012, Logan et al., 2012, Okada et al., 2012, Ziegenfuss et al., 2012, Shen and Codogno, 2011, Fernández-Ayala et al., 2010, McPhee et al., 2010, Thomson and Johnson, 2010, Fuentes-Medel et al., 2009, Kuraishi et al., 2008, Ziegenfuss et al., 2008, Kurucz et al., 2007, Kurucz et al., 2007)

Secondary FlyBase IDs

FBgn0035261

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (178)

Report Sections

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