BcDNA:GH03529
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Gene model reviewed during 5.41
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.46
None of the polypeptides share 100% sequence identity.
Interacts (via the cytoplasmic domain) with shark; this is required for the recruitment of drpr and glial cells to severed axons and for the phagocytosis of axonal debris by glial cells following axon injury (PubMed:18432193). Interacts with ced-6 (PubMed:16772168).
Phosphorylated on tyrosine residues (PubMed:18432193, PubMed:19927123, PubMed:23337816, PubMed:23420848). Phosphorylation is induced by binding to prtp (PubMed:19927123). It is also induced by binding to the membrane phospholipid phosphatidylserine (PubMed:23420848). Phosphorylation may be mediated directly or indirectly by Src42a and is required for interaction with shark (PubMed:18432193).
Isoform B: The intracellular domain is required for glial engulfment activity. Isoform A: The intracellular domain contains an 11-residue insertion compared to isoform B and is incapable of promoting glial engulfment.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\drpr using the Feature Mapper tool.
Comment: cyclical, peak ZT13-16
Comment: maternally deposited
Naive stage 11 macrophages have low levels of drpr transcripts and protein that increase after corpse uptake.
Some drpr isoforms are present at low levels in salivary glands and localize to the luminal/apical region at 6h APF. Following the rise in steroid levels that triggers cell death at 12h APF, drpr levels increase and remain high up to 14h APF, when some of the drpr changes from an apical to a cytoplasmic localization.
Comment: up-regulated in response to axotomy
Comment: up-regulated in response to axotomy
Comment: up-regulated in response to axotomy
Comment: up-regulated in response to axotomy
GBrowse - Visual display of RNA-Seq signals
View Dmel\drpr in GBrowse 23-1.0
3-1.0
3-2.7
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Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
monoclonal
Source for identity of: BcDNA:GH03529 CG2086
Source for identity of: drpr BcDNA:GH03529
Source for merge of: drpr CG18172
Isoform I of drpr, but not isoforms II or III, is sufficient for glial phagocytic engulfment of degenerating axons in the adult brain.
The drpr-II isoform inhibits glial phagocytic engulfment of degenerating axons through an ITIM-like domain.
drp is required for degradation of apoptotic cells after they have been engulfed during apoptotic cell clearance by glia in the nervous system and macrophages elsewhere.
drpr is needed in wild-type cells for the death of Minute neighbours in cell competition experiments.
In drpr mutants glia fail to respond morphologically to axon injury, and severed axons are not cleared from the CNS.
drpr is involved in the phagocytosis of apoptotic cells by hemocytes/macrophages.
Identification: by computational analysis looking for genes flanking gcm binding sites.