FB2021_06, released December 14, 2021

Gene: Dmel\drpr

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General Information
Symbol
Dmel\drpr
Species
D. melanogaster
Name
draper
Annotation Symbol
CG2086
Feature Type
protein_coding_gene
FlyBase ID
FBgn0027594
Gene Model Status
Current
Stock Availability
15 publicly available
Gene Summary
draper (drpr) encodes a single-pass transmembrane receptor that is involved in phagocytosis by glia, macrophages, and epithelia. It signals downstream through the proteins encoded by Src42A and Shark to promote Rac1 function and transcriptional changes through the products of Jra and Stat92E. It is also required for activation of autophagy in salivary glands. [Date last reviewed: 2019-03-21] (FlyBase Gene Snapshot)
All Summaries
Also Known As

BcDNA:GH03529

Key Links
Genomic Location
Cytogenetic map
62B1-62B1
Sequence location
Recombination map
3-1.0
RefSeq locus
NT_037436 REGION:1715595..1731107
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (22 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
enables phosphatidylserine binding
inferred from direct assay
(Tung et al., 2013)
enables protein binding
inferred from physical interaction with UniProtKB:Q7JUY7
(assigned by UniProt )
(Awasaki et al., 2006)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (15 terms)
Terms Based on Experimental Evidence (15 terms)
CV Term
Evidence
References
involved_in apoptotic cell clearance
inferred from mutant phenotype
(Doherty et al., 2009, Kurant et al., 2008, Ziegenfuss et al., 2008)
involved_in cell competition in a multicellular organism
inferred from mutant phenotype
(Li and Baker, 2007)
involved_in defense response to bacterium
inferred from mutant phenotype
(Hashimoto et al., 2009)
involved_in engulfment of apoptotic cell
inferred from mutant phenotype
(Etchegaray et al., 2012)
involved_in hydrogen peroxide mediated signaling pathway
inferred from mutant phenotype
(Campbell et al., 2021)
involved_in larval locomotory behavior
inferred from mutant phenotype
(Freeman et al., 2003)
involved_in neuron remodeling
inferred from mutant phenotype
(assigned by UniProt )
(Hoopfer et al., 2006)
inferred from mutant phenotype
(Awasaki et al., 2006)
involved_in phagocytosis, engulfment
inferred from mutant phenotype
(Tasdemir-Yilmaz and Freeman, 2014, Logan et al., 2012)
involved_in phagocytosis
inferred from mutant phenotype
(Hashimoto et al., 2009, Manaka et al., 2004)
involved_in positive regulation of inflammatory response to wounding
inferred from genetic interaction with FLYBASE:Pez; FB:FBgn0031799
(Campbell et al., 2021)
involved_in positive regulation of phagocytosis, engulfment
inferred from mutant phenotype
(Han et al., 2014)
involved_in regulation of neuromuscular junction development
inferred from mutant phenotype
(assigned by UniProt )
(Fuentes-Medel et al., 2009)
involved_in response to axon injury
inferred from mutant phenotype
(assigned by UniProt )
(MacDonald et al., 2006)
inferred from mutant phenotype
(Neukomm et al., 2014)
involved_in salivary gland cell autophagic cell death
inferred from mutant phenotype
(McPhee et al., 2010)
involved_in wing disc dorsal/ventral pattern formation
inferred from genetic interaction with FLYBASE:Bx; FB:FBgn0265598, FLYBASE:ap; FB:FBgn0267978
(Bejarano et al., 2008)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in phagocytosis
traceable author statement
(Evans et al., 2003)
Cellular Component (5 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
located_in axon
inferred from mutant phenotype
(assigned by UniProt )
(MacDonald et al., 2006)
located_in cytoplasm
inferred from direct assay
(assigned by UniProt )
(Etchegaray et al., 2012)
located_in plasma membrane
inferred from direct assay
(assigned by UniProt )
(Etchegaray et al., 2012, Freeman et al., 2003)
located_in postsynapse
inferred from mutant phenotype
(assigned by UniProt )
(Fuentes-Medel et al., 2009)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
located_in intrinsic component of membrane
non-traceable author statement
(Manaka et al., 2004)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the MEGF family. (Q9W0A0)
Protein Signatures (InterPro)
Summaries
Gene Snapshot
draper (drpr) encodes a single-pass transmembrane receptor that is involved in phagocytosis by glia, macrophages, and epithelia. It signals downstream through the proteins encoded by Src42A and Shark to promote Rac1 function and transcriptional changes through the products of Jra and Stat92E. It is also required for activation of autophagy in salivary glands. [Date last reviewed: 2019-03-21]
Gene Group (FlyBase)
NIMROD-TYPE RECEPTORS -
The Nimrod family of genes is characterised by the presence of NIM repeats, closely related to the EGF-repeat. They encode proteins which are secreted or integral to the plasma membrane. The Nimrod genes have been linked to the innate immune response and some members of this family have been shown to act as receptors for bacterial or apoptic cell phagocytosis. (Adapted from FBrf0212245).
Protein Function (UniProtKB)
Receptor which is involved in the phagocytosis of a variety of cells including apoptotic cells, severed and pruned axons, degenerating dendrites, salivary gland cells, germline cells and bacteria (PubMed:15342648, PubMed:16772168, PubMed:16772169, PubMed:18984163, PubMed:20577216, PubMed:22992958, PubMed:24412417). Binds to the ligand prtp which relocates from the endoplasmic reticulum to the cell surface during apoptosis (PubMed:19927123, PubMed:23337816). Ligand-binding may promote tyrosine phosphorylation mediated by Src42a, interaction with shark and subsequent activation of phagocytosis (PubMed:18432193). Also binds to the membrane phospholipid phosphatidylserine which is exposed on the surface of apoptotic cells (PubMed:23420848). Required for the phagocytosis of apoptotic cells by macrophages (PubMed:15342648). Also required for the phagocytosis of apoptotic neurons by glial cells in the embryonic nervous system (PubMed:12765609). Acts downstream of NimC4/simu in the glial phagocytosis of apoptotic neurons (PubMed:18455990). Plays a role in the glial engulfment of larval axons as part of programmed axon pruning during metamorphosis (PubMed:16772168, PubMed:16772170). Also mediates glial cell clearance of severed axons following axonal injury (PubMed:16772169, PubMed:27498858). Required for the engulfment of degenerating dendrites by epidermal cells (PubMed:24412417). Required in the ovary for the engulfment and subsequent processing of dying germline cells by follicular epithelial cells through activation of the JNK/bsk pathway (PubMed:22992958, PubMed:27347682). Plays a role in neuromuscular junction development by mediating the clearance of presynaptic debris and immature boutons which are shed by growing synapses (PubMed:19707574). Required for larval salivary gland cell death which occurs following a rise in steroid levels after puparium formation (PubMed:20577216). Also involved in bacterial phagocytosis (PubMed:18984163). Required for hemocyte phagocytosis of the Gram-positive bacterium S.aureus (PubMed:19890048). Lipoteichoic acid, synthesized by the S.aureus lipoteichoic acid synthase ltaS, acts as a ligand for drpr in this process (PubMed:19890048). Together with Src42a and shark, promotes the migration of macrophages to sites of wounding as part of a signaling cascade where Scr42a detects production of hydrogen peroxide at wound sites which triggers phosphorylation of drpr and subsequent recruitment and activation of shark (PubMed:26028435). Also required for macrophage priming which occurs following phagocytosis of apoptotic cells and ensures that macrophages develop a form of molecular memory that allows them to later mount an inflammatory response to tissue damage and bacterial infection (PubMed:27212238). Is also an essential factor in the regulation of muscle development and myogenesis, and as a consequence is required for normal locomotion (PubMed:12765609, PubMed:25111228, Ref.27). Likely to control the balance between skeletal muscle satellite cells proliferation and differentiation through regulation of the notch signaling pathway (PubMed:25111228, PubMed:30802937, Ref.27).
(UniProt, Q9W0A0)
Summary (Interactive Fly)
Gene Model and Products
Number of Transcripts
6
Number of Unique Polypeptides
6

Please see the JBrowse view of Dmel\drpr for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.41

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
drpr-RA
FBtr0072798
NM_058102
3206
594
drpr-RB
FBtr0072799
NM_167911
4517
1031
drpr-RC
FBtr0309845
NM_001259620
3298
528
drpr-RD
FBtr0334078
NM_001274346
3148
613
drpr-RE
FBtr0334079
NM_001274347
4435
1042
drpr-RF
FBtr0334080
NM_001274348
4757
976
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
drpr-PA
FBpp0072680
66.2
594
6.51
NP_477450
AAF47552
drpr-PB
FBpp0072681
113.0
1031
5.96
NP_728660
AAF47553
drpr-PC
FBpp0301579
58.7
528
6.69
NP_001246549
AFH04220
drpr-PD
FBpp0306203
68.3
613
6.48
NP_001261275
AGB93970
drpr-PE
FBpp0306204
114.3
1042
6.01
NP_001261276
AGB93971
drpr-PF
FBpp0306205
106.8
976
6.10
NP_001261277
AGB93972
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Interacts (via the cytoplasmic domain) with shark; this is required for the recruitment of drpr and glial cells to severed axons and for the phagocytosis of axonal debris by glial cells following axon injury (PubMed:18432193). Interacts with ced-6 (PubMed:16772168).

(UniProt, Q9W0A0)
Post Translational Modification

Phosphorylated on tyrosine residues (PubMed:18432193, PubMed:19927123, PubMed:23337816, PubMed:23420848). Phosphorylation is induced by binding to prtp (PubMed:19927123). It is also induced by binding to the membrane phospholipid phosphatidylserine (PubMed:23420848). Phosphorylation may be mediated directly or indirectly by Src42a and is required for interaction with shark (PubMed:18432193).

(UniProt, Q9W0A0)
Domain

Isoform B: The intracellular domain is required for glial engulfment activity. Isoform A: The intracellular domain contains an 11-residue insertion compared to isoform B and is incapable of promoting glial engulfment.

(UniProt, Q9W0A0)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\drpr using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
expression microarray
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult fat body

Comment: cyclical, peak ZT13-16

(Xu et al., 2011)
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 11 -- 15
embryonic/larval plasmatocyte
(Weavers et al., 2016)
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
third instar larval stage
glial cell | subset of brain | faint
(Awasaki et al., 2006)
prepupal stage P3
glial cell | subset of brain

Comment: 6h APF

(Awasaki et al., 2006)
prepupal stage P4(ii)
glial cell | subset of brain | faint

Comment: 12h APF

(Awasaki et al., 2006)
Additional Descriptive Data

Naive stage 11 macrophages have low levels of drpr transcripts and protein that increase after corpse uptake.

(Weavers et al., 2016)

Expressed cyclically in the adult fat body.

(Xu et al., 2011)

drpr transcript is detected in a subset of glial cells that surround the distal tip of the mushroom body vertical lobes.

(Awasaki et al., 2006)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
prepupal stage P2 -- P3
astrocyte-like glial cell of neuropil
(Tasdemir-Yilmaz and Freeman, 2014)
prepupal stage P3
glial cell | subset of brain

Comment: 6h APF

(Awasaki et al., 2006)
mushroom body vertical lobe | restricted

Comment: 6h APF

(Awasaki et al., 2006)
prepupal stage P3 -- P4
embryonic/larval salivary gland
(McPhee et al., 2010)
adult stage
glial cell of adult brain
(MacDonald et al., 2006)
glial cell of adult antennal lobe
(MacDonald et al., 2006)
adult brain cell body glial cell of adult antennal lobe

Comment: up-regulated in response to axotomy

(Doherty et al., 2014, Doherty et al., 2009)
adult ensheathing glial cell of adult antennal lobe
(Doherty et al., 2009)
adult ensheathing glial cell
(Doherty et al., 2014)
adult brain cell body glial cell
(Doherty et al., 2014)
oogenesis
follicle cell | subset

Comment: in dying egg chambers

(Etchegaray et al., 2012)
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 11 -- 15
embryonic/larval plasmatocyte
(Weavers et al., 2016)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult brain
(Doherty et al., 2014)
Additional Descriptive Data

Naive stage 11 macrophages have low levels of drpr transcripts and protein that increase after corpse uptake.

(Weavers et al., 2016)

drpr protein is expressed in the follicle cells of dying egg chambers. drpr protein levels increase in follicle cells as engulfment of nurse cells by follicle cells in dying egg chambers proceeds.

(Etchegaray et al., 2012)

Some drpr isoforms are present at low levels in salivary glands and localize to the luminal/apical region at 6h APF. Following the rise in steroid levels that triggers cell death at 12h APF, drpr levels increase and remain high up to 14h APF, when some of the drpr changes from an apical to a cytoplasmic localization.

(McPhee et al., 2010)

drpr protein is detected in a subset of glial cells that surround the distal tip of the mushroom body vertical lobes. These cells also express ced-6 protein. Expression in also detected in glial processes that infiltrate the vertical lobes.

(Awasaki et al., 2006)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in axon
inferred from mutant phenotype
(assigned by UniProt )
(MacDonald et al., 2006)
located_in cytoplasm
inferred from direct assay
(assigned by UniProt )
(Etchegaray et al., 2012)
located_in plasma membrane
inferred from direct assay
(assigned by UniProt )
(Etchegaray et al., 2012, Freeman et al., 2003)
located_in postsynapse
inferred from mutant phenotype
(assigned by UniProt )
(Fuentes-Medel et al., 2009)
Expression Deduced from Reporters
Reporter: P{drpr-GAL4.ee7.MUT}
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult brain cell body glial cell

Comment: up-regulated in response to axotomy

(Doherty et al., 2014)
adult brain cell body glial cell of adult antennal lobe

Comment: up-regulated in response to axotomy

(Doherty et al., 2014)
astrocyte-like glial cell | faint
(Doherty et al., 2014)
adult ensheathing glial cell

Comment: up-regulated in response to axotomy

(Doherty et al., 2014)
Reporter: P{drpr-GAL4.ee7}
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult brain cell body glial cell

Comment: up-regulated in response to axotomy

(Doherty et al., 2014)
adult brain cell body glial cell of adult antennal lobe

Comment: up-regulated in response to axotomy

(Doherty et al., 2014)
astrocyte-like glial cell | faint
(Doherty et al., 2014)
adult ensheathing glial cell

Comment: up-regulated in response to axotomy

(Doherty et al., 2014)
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\drpr in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 18 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 22 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of drpr
Transgenic constructs containing regulatory region of drpr
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation ( 1 )
Gene partially disrupted in
Df(3L)drprΔ5
(Draper et al., 2014)
Inferred from location ( 0 )
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal - all die before end of larval stage, with Scer\GAL4- :
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
abnormal cell death | adult stage | germline clone | nutrition conditional
abnormal cell death | adult stage | nutrition conditional
abnormal cell death | adult stage | nutrition conditional, with Scer\GAL4GR1
abnormal immune response | conditional
abnormal locomotor behavior | adult stage, with Scer\GAL4Act5C.PI
abnormal locomotor behavior | adult stage, with Scer\GAL4how-24B
abnormal locomotor behavior | adult stage, with Scer\GAL4twi.PG
abnormal locomotor behavior | adult stage | progressive | recessive
abnormal locomotor behavior | larval stage, with Scer\GAL4- :
abnormal neuroanatomy
abnormal neuroanatomy, with Scer\GAL4alrm.PD
abnormal neuroanatomy, with Scer\GAL4repo.PU
abnormal neuroanatomy | adult stage
abnormal neuroanatomy | conditional, with Scer\GAL4Gli-rL82
abnormal neuroanatomy | conditional, with Scer\GAL4nrv2.PS
abnormal neuroanatomy | conditional, with Scer\GAL4repo
abnormal neuroanatomy | conditional, with Scer\GAL4VGlut-OK371
abnormal neuroanatomy | larval stage | conditional, with Scer\GAL4A58
abnormal neuroanatomy | larval stage | conditional (with Df(3L)BSC181)
abnormal neuroanatomy | P-stage, with Scer\GAL4repo
abnormal neuroanatomy | pupal stage
abnormal neuroanatomy | pupal stage, with Scer\GAL4en-e16E
abnormal neuroanatomy | pupal stage (with Df(3L)BSC181)
increased cell death | adult stage, with Scer\GAL4GR1
short lived | recessive
some die during larval stage, with Scer\GAL4- :
uncoordinated | larval stage, with Scer\GAL4- :
Phenotype manifest in
Allele
adult brain
adult brain, with Scer\GAL4Act5C.PI
adult ensheathing glial cell, with Scer\GAL4Mz709
adult ensheathing glial cell, with Scer\GAL4repo.PU
adult mushroom body
adult olfactory receptor neuron
adult olfactory receptor neuron, with Scer\GAL4repo.PU
astrocyte-like glial cell
astrocyte-like glial cell, with Scer\GAL4alrm.PD
dendrite
egg chamber
egg chamber | germline clone | nutrition conditional
egg chamber | nutrition conditional
egg chamber | nutrition conditional, with Scer\GAL4GR1
embryonic/larval hemocyte
embryonic/larval salivary gland
embryonic/larval salivary gland, with Scer\GAL4fkh.PH
follicle cell | nutrition conditional
follicle cell | nutrition conditional, with Scer\GAL4GR1
gamma Kenyon cell
gamma Kenyon cell, with Scer\GAL4alrm.PD
gamma Kenyon cell | pupal stage
glial cell
glial cell, with Scer\GAL4repo
larval dorsal multidendritic neuron ddaC
larval dorsal multidendritic neuron ddaC | larval stage | conditional, with Scer\GAL4A58
larval dorsal multidendritic neuron ddaC | larval stage | conditional (with Df(3L)BSC181)
larval dorsal multidendritic neuron ddaC | pupal stage, with Scer\GAL4en-e16E
larval dorsal multidendritic neuron ddaC | pupal stage (with Df(3L)BSC181)
lysosome, with Scer\GAL4fkh.PH
muscle cell of mesothoracic extracoxal depressor muscle 66
muscle cell of mesothoracic extracoxal depressor muscle 66, with Scer\GAL4Act5C.PI
nurse cell
nurse cell, with Scer\GAL4GR1
retina
wing vein L1 | conditional, with Scer\GAL4Gli-rL82
wing vein L1 | conditional, with Scer\GAL4nrv2.PS
wing vein L1 | conditional, with Scer\GAL4repo
wing vein L1 | conditional, with Scer\GAL4VGlut-OK371
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (37)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\MEGF10
12 of 15
Yes
Yes
Hsap\MEGF11
11 of 15
No
Yes
2  
Hsap\PEAR1
8 of 15
No
Yes
2  
Hsap\MEGF6
3 of 15
No
Yes
Hsap\CCBE1
1 of 15
No
Yes
Hsap\CRB2
1 of 15
No
No
Hsap\CSF1R
1 of 15
No
No
Hsap\DKK1
1 of 15
No
Yes
Hsap\DKK2
1 of 15
No
Yes
Hsap\DKK3
1 of 15
No
Yes
Hsap\DKK4
1 of 15
No
Yes
Hsap\ESM1
1 of 15
No
No
Hsap\FGFR1
1 of 15
No
No
Hsap\FGFR2
1 of 15
No
No
Hsap\FGFR3
1 of 15
No
No
Hsap\FGFR4
1 of 15
No
No
2  
Hsap\FGFRL1
1 of 15
No
No
Hsap\FLT1
1 of 15
No
No
Hsap\FLT3
1 of 15
No
No
Hsap\FLT4
1 of 15
No
No
Hsap\GAS6
1 of 15
No
Yes
Hsap\KDR
1 of 15
No
No
2  
Hsap\KIT
1 of 15
No
No
Hsap\MSANTD3-TMEFF1
1 of 15
No
Yes
Hsap\PDGFRA
1 of 15
No
No
Hsap\PDGFRB
1 of 15
No
No
2  
Hsap\PDGFRL
1 of 15
No
Yes
Hsap\RET
1 of 15
No
No
1  
Hsap\SCARF1
1 of 15
No
Yes
Hsap\SCARF2
1 of 15
No
Yes
Hsap\STAB1
1 of 15
No
Yes
Hsap\STAB2
1 of 15
No
Yes
Hsap\STYK1
1 of 15
No
No
Hsap\TEK
1 of 15
No
No
Hsap\TIE1
1 of 15
No
No
Hsap\TMEFF2
1 of 15
No
No
Hsap\TNFAIP6
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (37)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Megf10
12 of 15
Yes
Yes
Mmus\Megf11
12 of 15
Yes
Yes
Mmus\Pear1
7 of 15
No
Yes
Mmus\Megf6
3 of 15
No
Yes
Mmus\Egfem1
2 of 15
No
Yes
Mmus\Ccbe1
1 of 15
No
No
Mmus\Csf1r
1 of 15
No
No
Mmus\Dkk1
1 of 15
No
Yes
Mmus\Dkk2
1 of 15
No
Yes
Mmus\Dkk3
1 of 15
No
Yes
Mmus\Dkk4
1 of 15
No
Yes
Mmus\Esm1
1 of 15
No
Yes
Mmus\Fgfr1
1 of 15
No
No
Mmus\Fgfr2
1 of 15
No
No
Mmus\Fgfr3
1 of 15
No
No
Mmus\Fgfr4
1 of 15
No
No
Mmus\Fgfrl1
1 of 15
No
No
Mmus\Flt1
1 of 15
No
No
Mmus\Flt3
1 of 15
No
No
Mmus\Flt4
1 of 15
No
No
Mmus\Gas6
1 of 15
No
Yes
Mmus\Kdr
1 of 15
No
No
Mmus\Kit
1 of 15
No
No
Mmus\Pdgfra
1 of 15
No
No
Mmus\Pdgfrb
1 of 15
No
No
Mmus\Pdgfrl
1 of 15
No
Yes
Mmus\Ret
1 of 15
No
No
Mmus\Scarf1
1 of 15
No
Yes
Mmus\Scarf2
1 of 15
No
Yes
Mmus\Stab1
1 of 15
No
Yes
Mmus\Stab2
1 of 15
No
Yes
Mmus\Styk1
1 of 15
No
No
Mmus\Tek
1 of 15
No
No
Mmus\Tie1
1 of 15
No
No
Mmus\Tmeff1
1 of 15
No
No
Mmus\Tmeff2
1 of 15
No
No
Mmus\Tnfaip6
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (33)
Rnor\Megf11
11 of 13
Yes
Yes
Rnor\Megf10
10 of 13
No
Yes
Rnor\Pear1
6 of 13
No
Yes
Rnor\LOC100911486
2 of 13
No
Yes
Rnor\Megf6
2 of 13
No
Yes
Rnor\Csf1r
1 of 13
No
No
Rnor\Dkk1
1 of 13
No
Yes
Rnor\Dkk2
1 of 13
No
Yes
Rnor\Dkk3
1 of 13
No
Yes
Rnor\Dkk4
1 of 13
No
Yes
Rnor\Esm1
1 of 13
No
Yes
Rnor\Fgfr1
1 of 13
No
No
Rnor\Fgfr2
1 of 13
No
No
Rnor\Fgfr3
1 of 13
No
No
Rnor\Fgfr4
1 of 13
No
No
Rnor\Fgfrl1
1 of 13
No
No
Rnor\Flt1
1 of 13
No
No
Rnor\Flt4
1 of 13
No
No
Rnor\Gas6
1 of 13
No
Yes
Rnor\Kdr
1 of 13
No
No
Rnor\Kit
1 of 13
No
No
Rnor\Pdgfra
1 of 13
No
No
Rnor\Pdgfrb
1 of 13
No
No
Rnor\Pdgfrl
1 of 13
No
Yes
Rnor\Ret
1 of 13
No
No
Rnor\Scarf2
1 of 13
No
Yes
Rnor\Stab1
1 of 13
No
Yes
Rnor\Stab2
1 of 13
No
Yes
Rnor\Styk1
1 of 13
No
No
Rnor\Tek
1 of 13
No
No
Rnor\Tie1
1 of 13
No
No
Rnor\Tmeff1
1 of 13
No
No
Rnor\Tnfaip6
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (31)
Xtro\megf10
8 of 12
Yes
Yes
Xtro\megf11
7 of 12
No
Yes
Xtro\pear1
4 of 12
No
Yes
Xtro\adgre2
1 of 12
No
Yes
Xtro\ccbe1
1 of 12
No
Yes
Xtro\csf1r
1 of 12
No
No
Xtro\dkk1
1 of 12
No
Yes
Xtro\dkk2
1 of 12
No
Yes
Xtro\dkk3
1 of 12
No
Yes
Xtro\esm1
1 of 12
No
Yes
Xtro\fgfr1
1 of 12
No
No
Xtro\fgfr2
1 of 12
No
No
Xtro\fgfr3
1 of 12
No
No
Xtro\fgfr4
1 of 12
No
No
Xtro\fgfrl1
1 of 12
No
No
Xtro\flt1
1 of 12
No
No
Xtro\flt4
1 of 12
No
No
Xtro\gas6
1 of 12
No
Yes
Xtro\kdr
1 of 12
No
No
Xtro\LOC100493937
1 of 12
No
Yes
Xtro\LOC108645475
1 of 12
No
Yes
Xtro\pdgfra
1 of 12
No
No
Xtro\pdgfrl.2
1 of 12
No
Yes
Xtro\pdgfrl
1 of 12
No
Yes
Xtro\ret
1 of 12
No
No
Xtro\scarf2
1 of 12
No
Yes
Xtro\stab2
1 of 12
No
Yes
Xtro\styk1
1 of 12
No
No
Xtro\tek
1 of 12
No
No
Xtro\tie1
1 of 12
No
No
Xtro\tnfaip6
1 of 12
No
Yes
Danio rerio (Zebrafish) (43)
Drer\megf11
12 of 15
Yes
Yes
Drer\pear1
10 of 15
No
Yes
Drer\megf10
8 of 15
No
Yes
Drer\megf6a
3 of 15
No
Yes
Drer\megf6b
3 of 15
No
Yes
Drer\zgc:158328
3 of 15
No
Yes
Drer\ccbe1
1 of 15
No
No
Drer\csf1ra
1 of 15
No
No
Drer\csf1rb
1 of 15
No
No
Drer\dkk1a
1 of 15
No
Yes
Drer\dkk1b
1 of 15
No
Yes
Drer\dkk2
1 of 15
No
Yes
Drer\dkk3b
1 of 15
No
Yes
Drer\esm1
1 of 15
No
Yes
Drer\fgfr1a
1 of 15
No
No
Drer\fgfr3
1 of 15
No
No
Drer\fgfr4
1 of 15
No
No
Drer\fgfrl1a
1 of 15
No
No
Drer\fgfrl1b
1 of 15
No
No
Drer\flt1
1 of 15
No
No
Drer\flt3
1 of 15
No
No
Drer\flt4
1 of 15
No
No
Drer\kdr
1 of 15
No
No
Drer\kdrl
1 of 15
No
No
Drer\kita
1 of 15
No
No
Drer\kitb
1 of 15
No
No
Drer\pdgfra
1 of 15
No
No
Drer\pdgfrb
1 of 15
No
No
Drer\pdgfrl
1 of 15
No
Yes
Drer\ret
1 of 15
No
No
Drer\scarf1
1 of 15
No
Yes
Drer\si:ch73-206d17.1
1 of 15
No
No
Drer\si:ch211-221n20.8
1 of 15
No
No
Drer\stab1
1 of 15
No
Yes
Drer\stab2
1 of 15
No
Yes
Drer\styk1a
1 of 15
No
No
Drer\styk1b
1 of 15
No
No
Drer\tek
1 of 15
No
No
Drer\tie1
1 of 15
No
Yes
Drer\tmeff1a
1 of 15
No
Yes
Drer\tmeff1b
1 of 15
No
Yes
Drer\tmeff2a
1 of 15
No
Yes
Drer\tnfaip6
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (50)
Cele\ced-1
14 of 15
Yes
Yes
Cele\Y64G10A.7
4 of 15
No
Yes
Cele\D1044.7
2 of 15
No
No
Cele\arg-1
1 of 15
No
No
Cele\B0252.1
1 of 15
No
No
Cele\C53B7.2
1 of 15
No
No
Cele\dsl-1
1 of 15
No
Yes
Cele\dsl-2
1 of 15
No
Yes
Cele\dsl-3
1 of 15
No
Yes
Cele\dsl-5
1 of 15
No
Yes
Cele\dsl-6
1 of 15
No
Yes
Cele\dsl-7
1 of 15
No
Yes
Cele\egl-15
1 of 15
No
No
Cele\F07H5.8
1 of 15
No
No
Cele\F09A5.2
1 of 15
No
No
Cele\F09G2.1
1 of 15
No
No
Cele\F40G9.8
1 of 15
No
Yes
Cele\F46B3.15
1 of 15
No
Yes
Cele\F48E3.8
1 of 15
No
No
Cele\F56B3.2
1 of 15
No
Yes
Cele\F59F5.3
1 of 15
No
No
Cele\far-5
1 of 15
No
Yes
Cele\hir-1
1 of 15
No
No
Cele\igcm-4
1 of 15
No
No
Cele\kin-9
1 of 15
No
No
Cele\kin-15
1 of 15
No
No
Cele\kin-23
1 of 15
No
No
Cele\kin-30
1 of 15
No
No
Cele\lag-2
1 of 15
No
Yes
Cele\lgx-1
1 of 15
No
No
Cele\M03F4.6
1 of 15
No
No
Cele\old-1
1 of 15
No
No
Cele\old-2
1 of 15
No
No
Cele\pqn-25
1 of 15
No
No
Cele\R09D1.12
1 of 15
No
No
Cele\R09D1.13
1 of 15
No
No
Cele\R151.1
1 of 15
No
No
Cele\sdz-23
1 of 15
No
Yes
Cele\T01G5.1
1 of 15
No
No
Cele\T12A7.2
1 of 15
No
Yes
Cele\ver-1
1 of 15
No
No
Cele\ver-2
1 of 15
No
No
Cele\ver-3
1 of 15
No
No
Cele\ver-4
1 of 15
No
No
Cele\W03A5.1
1 of 15
No
No
Cele\W04G5.10
1 of 15
No
No
Cele\Y38H6C.20
1 of 15
No
Yes
Cele\Y41D4B.26
1 of 15
No
Yes
Cele\Y50D4B.6
1 of 15
No
No
Cele\zig-13
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (1)
Atha\AT2G34123
1 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091900Y7 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00004463
Drosophila simulans
Dsim\GD13447
Drosophila sechellia
Dsec\GM14179
Drosophila erecta
Dere\GG14570
Drosophila yakuba
Dyak\GE20925
Drosophila ananassae
Dana\GF24971
Drosophila pseudoobscura pseudoobscura
Dpse\GA23962
Drosophila persimilis
Dper\GL11918
Drosophila willistoni
Dwil\GK17064
Drosophila virilis
Dvir\GJ12529
Drosophila mojavensis
Dmoj\GI16787
Drosophila grimshawi
Dgri\GH15511
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500O6 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17021923
Glossina morsitans
Tsetse fly
Gmor\GMOY009946
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_13493
Mayetiola destructor
Hessian fly
Mdes\Mdes004844
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL008198
Anopheles darlingi
American malaria mosquito
Adar\ADAC008908
Anopheles gambiae
Malaria mosquito
Agam\AGAP007256
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ002121
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W05IV )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA012538
Danaus plexippus
Monarch butterfly
Dple\DPOGS208973-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL002647
Apis florea
Little honeybee
Aflo\2530298356
Apis mellifera
Western honey bee
Amel\GB54664
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP21452
Bombus terrestris
Buff-tailed bumblebee
Bter\15211163
Linepithema humile
Argentine ant
Lhum\LH12096
Linepithema humile
Argentine ant
Lhum\LH12097
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002d21
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002d22
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG003412
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_00482
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_00301
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_05454
Tribolium castaneum
Red flour beetle
Tcas\drpr
Pediculus humanus
Human body louse
Phum\PHUM049590
Rhodnius prolixus
Kissing bug
Rpro\RPRC002422
Cimex lectularius
Bed bug
Clec\CLEC004060
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI001685
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_06222
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X05F0 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR000981
Strigamia maritima
European centipede
Smar\SMAR004984
Ixodes scapularis
Black-legged tick
Isca\ISCW020553
Ixodes scapularis
Black-legged tick
Isca\ISCW024127
Stegodyphus mimosarum
African social velvet spider
Smim\KFM78730.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM78731.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM77793.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM71170.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM61145.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur08g04300
Tetranychus urticae
Two-spotted spider mite
Turt\tetur04g05840
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_47122
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G00XN )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Megf6
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-EMI/Egf
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Megf11_2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Megf6_4
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Megf6-2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Hypp_2282
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Megf6L
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Megf11
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Megf6-3
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000002306
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000007631
Gallus gallus
Domestic chicken
Ggal\MEGF10
Gallus gallus
Domestic chicken
Ggal\LOC424998
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000028622
Gallus gallus
Domestic chicken
Ggal\MEGF6
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (26)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
CG7381
2 of 10
CG11674
2 of 10
NimA
2 of 10
btl
1 of 10
Cad96Ca
1 of 10
CG3277
1 of 10
CG5883
1 of 10
CG15861
1 of 10
CG17145
1 of 10
CG17147
1 of 10
eater
1 of 10
htl
1 of 10
NimB1
1 of 10
NimB2
1 of 10
NimB3
1 of 10
NimB4
1 of 10
NimB5
1 of 10
NimC1
1 of 10
NimC2
1 of 10
NimC3
1 of 10
NimC4
1 of 10
Pvr
1 of 10
Ret
1 of 10
Tie
1 of 10
tor
1 of 10
Wsck
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 2 )
Allele
Disease
Evidence
References
drprΔ5
model of  myopathy
CEA
(Draper et al., 2014)
drprGD14423
model of  myopathy
CEA
(Draper et al., 2014)
Potential Models Based on Orthology ( 1 )
Modifiers Based on Experimental Evidence ( 3 )
Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
MEGF10; multiple EGF like domains 10
12 of 15
612453
MEGF11; multiple EGF like domains 11
11 of 15
612454
       
      PEAR1; platelet endothelial aggregation receptor 1
      8 of 15
      610278
           
          MEGF6; multiple EGF like domains 6
          3 of 15
          604266
              Functional Complementation Data
              Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
              Interactions
              Summary of Physical Interactions
              Summary of Genetic Interactions
              esyN Network Diagram
              esyN Network Key:
              Suppression
              Enhancement
              View in Interactions Browser
              Please look at the allele data for full details of the genetic interactions
              Starting gene(s)
              Interaction type
              Interacting gene(s)
              Reference
              drpr
              suppressible
              Atg1
              (McPhee et al., 2010)
              drpr
              enhanceable
              Ced-12
              (Tasdemir-Yilmaz and Freeman, 2014)
              drpr
              enhanceable
              Crk
              (Tasdemir-Yilmaz and Freeman, 2014)
              drpr
              suppressible
              hep
              (Etchegaray et al., 2012)
              drpr
              enhanceable
              Itgbn
              (Nagaosa et al., 2011)
              Starting gene(s)
              Interaction type
              Interacting gene(s)
              Reference
              Bx
              suppressible
              drpr
              (Bejarano et al., 2008)
              Bx|ap
              suppressible
              drpr
              (Bejarano et al., 2008)
              CDC50
              suppressible
              drpr
              (Sapar et al., 2018)
              ced-6
              enhanceable
              drpr
              (Awasaki et al., 2006)
              Itgbn
              enhanceable
              drpr
              (Nagaosa et al., 2011)
              repo
              suppressible
              NimC4|drpr
              (Shklyar et al., 2014)
              External Data
              Subunit Structure (UniProtKB)
              Interacts (via the cytoplasmic domain) with shark; this is required for the recruitment of drpr and glial cells to severed axons and for the phagocytosis of axonal debris by glial cells following axon injury (PubMed:18432193). Interacts with ced-6 (PubMed:16772168).
              (UniProt, Q9W0A0 )
              Linkouts
              BioGRID - A database of protein and genetic interactions.
              DroID - A comprehensive database of gene and protein interactions.
              MIST (protein-protein) - An integrated Molecular Interaction Database
              Pathways
              Signaling Pathways (FlyBase)
              Metabolic Pathways
              FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
              External Data
              Linkouts
              Genomic Location and Detailed Mapping Data
              Chromosome (arm)
              3L
              Recombination map
              3-1.0
              Cytogenetic map
              62B1-62B1
              Sequence location
              FlyBase Computed Cytological Location
              Cytogenetic map
              Evidence for location
              62B1-62B1
              Limits computationally determined from genome sequence between P{EP}rhoEP3704&P{PZ}l(3)0622606226 and P{PZ}dlt04276
              Experimentally Determined Cytological Location
              Cytogenetic map
              Notes
              References
              Experimentally Determined Recombination Data
              Location

              3-1.0

              (FlyBase, 2016)

              3-2.7

              (Comeron et al., 2012)
              Left of (cM)
              Right of (cM)
              Notes
              Stocks and Reagents
              Stocks (15)
              Genomic Clones (25)
              cDNA Clones (73)
               

              Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

              cDNA clones, fully sequenced
              BDGP DGC clones
              Other clones
              Drosophila Genomics Resource Center cDNA clones

              For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

              cDNA Clones, End Sequenced (ESTs)
              BDGP DGC clones
              Other clones
              RNAi and Array Information
              Linkouts
              DRSC - Results frm RNAi screens
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              Antibody Information
              Laboratory Generated Antibodies
               

              monoclonal

              (Musashe et al., 2016)
              Commercially Available Antibodies
               
              Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
              Other Information
              Relationship to Other Genes
              Source for database identify of

              Source for identity of: BcDNA:GH03529 CG2086

              (Deng, 1999.11)

              Source for identity of: drpr BcDNA:GH03529

              (Freeman, 2002.3.5, Freeman et al., 2001)
              Source for database merge of

              Source for merge of: drpr CG18172

              (FlyBase Genome Annotators, 2002-2003)
              Additional comments
              Other Comments

              Isoform I of drpr, but not isoforms II or III, is sufficient for glial phagocytic engulfment of degenerating axons in the adult brain.

              (Logan et al., 2012)

              The drpr-II isoform inhibits glial phagocytic engulfment of degenerating axons through an ITIM-like domain.

              (Logan et al., 2012)

              drp is required for degradation of apoptotic cells after they have been engulfed during apoptotic cell clearance by glia in the nervous system and macrophages elsewhere.

              (Kurant et al., 2008)

              drpr is needed in wild-type cells for the death of Minute neighbours in cell competition experiments.

              (Li and Baker, 2007)

              In drpr mutants glia fail to respond morphologically to axon injury, and severed axons are not cleared from the CNS.

              (MacDonald et al., 2006)

              drpr is involved in the phagocytosis of apoptotic cells by hemocytes/macrophages.

              (Manaka et al., 2004)

              Identification: by computational analysis looking for genes flanking gcm binding sites.

              (Freeman et al., 2001)
              Origin and Etymology
              Discoverer
              Etymology
              Identification
              External Crossreferences and Linkouts ( 66 )
              Sequence Crossreferences
              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
              UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
              UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
              Other crossreferences
              BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
              DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
              EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
              Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
              FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
              Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
              Flygut - An atlas of the Drosophila adult midgut
              FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
              InterPro - A database of protein families, domains and functional sites
              KEGG Genes - Molecular building blocks of life in the genomic space.
              MARRVEL_MODEL - MARRVEL (model organism gene)
              modMine - A data warehouse for the modENCODE project
              Linkouts
              BioGRID - A database of protein and genetic interactions.
              DroID - A comprehensive database of gene and protein interactions.
              DRSC - Results frm RNAi screens
              Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
              FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
              FlyMine - An integrated database for Drosophila genomics
              Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
              MIST (protein-protein) - An integrated Molecular Interaction Database
              Synonyms and Secondary IDs (12)
              Reported As
              Symbol Synonym
              BcDNA:GH03529
              (Egger et al., 2002)
              CED-1
              (Davidson and Wood, 2020)
              CG18172
              (Freeman, 2002.3.5)
              CG2086
              (Ni et al., 2011.7.19, Piacentini et al., 2009, Kurucz et al., 2007, Qin et al., 2005)
              CT41022
              (Hynes and Zhao, 2000)
              CT6730
              (Hynes and Zhao, 2000)
              DRPR
              (Chorna and Hasan, 2012)
              Draper
              (Jeon et al., 2020, Ekowati et al., 2017, Nainu et al., 2017, Wood and Martin, 2017, Péan and Dionne, 2014, Fang and Bonini, 2012)
              Draper I
              (Freeman, 2015)
              Drpr
              (Furusawa and Emoto, 2021, Hilu-Dadia and Kurant, 2020, Xu et al., 2020, Etchegaray et al., 2012, Shen and Codogno, 2011, Fuentes-Medel et al., 2009)
              draper
              (Musashe et al., 2016, Levayer and Moreno, 2013, Kurant, 2011, Somogyi et al., 2010, Williams et al., 2006)
              drpr
              (Boulanger et al., 2021, Buhlman et al., 2021, Coppens et al., 2021, Gerenu et al., 2021, Hsu et al., 2021, Lebo and McCall, 2021, Lebo et al., 2021, Yin et al., 2021, Donnelly et al., 2020, Faber et al., 2020, Asri et al., 2019, Banerjee et al., 2019, Engel et al., 2019, Melcarne et al., 2019, Melcarne et al., 2019, Nakano et al., 2019, Saha et al., 2019, Sapar and Han, 2019, Yang and Chien, 2019, Santoso et al., 2018, Shlyakhover et al., 2018, Fochler et al., 2017, Lu et al., 2017, Ray et al., 2017, Etchegaray et al., 2016, Okuda et al., 2016, Weavers et al., 2016, Gene Disruption Project members, 2015-, Nainu et al., 2015, Ashwal-Fluss et al., 2014, Doherty et al., 2014, Draper et al., 2014, Han et al., 2014, Neukomm et al., 2014, Shklyar et al., 2014, Tasdemir-Yilmaz and Freeman, 2014, Lavagnino et al., 2013, Tung et al., 2013, Etchegaray et al., 2012, Fujita et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Logan et al., 2012, Okada et al., 2012, Shiratsuchi et al., 2012, Gafuik and Steller, 2011, Nagaosa et al., 2011, Xu et al., 2011, McPhee et al., 2010, Thomson and Johnson, 2010, Kuraishi et al., 2009, Martín et al., 2009, Cuttell et al., 2008, Kurant et al., 2008, Hueber et al., 2007, Kuraishi et al., 2007, Li and Baker, 2007, Zhang et al., 2007, Awasaki et al., 2006, Hoopfer et al., 2006)
              Name Synonyms
              Draper
              (Bolus et al., 2020, Davidson and Wood, 2020, Hilu-Dadia and Kurant, 2020, Kessissoglou et al., 2020, Kim et al., 2020, Lu et al., 2020, Stanhope et al., 2020, Younes et al., 2020, Kounatidis and Chtarbanova, 2018, Losada-Perez, 2018, Williamson and Vale, 2018, Kutscher and Shaham, 2017, Lu et al., 2017, Purice et al., 2017, Meehan et al., 2016, Parsons and Foley, 2016, Purice et al., 2016, Weavers et al., 2016, Erdmann et al., 2015, Lee and Sun, 2015, Pearce et al., 2015, Stratoulias and Heino, 2015, Vlisidou and Wood, 2015, Amoyel and Bach, 2014, Doherty et al., 2014, Han et al., 2014, Lu et al., 2014, Wang et al., 2014, Corty and Freeman, 2013, Jenkins et al., 2013, Levayer and Moreno, 2013, Macdonald et al., 2013, Etchegaray et al., 2012, Fujita et al., 2012, Igboin et al., 2012, Kounatidis and Ligoxygakis, 2012, Logan et al., 2012, Okada et al., 2012, Ziegenfuss et al., 2012, Shen and Codogno, 2011, Fernández-Ayala et al., 2010, McPhee et al., 2010, Thomson and Johnson, 2010, Fuentes-Medel et al., 2009, Kuraishi et al., 2008, Ziegenfuss et al., 2008, Kurucz et al., 2007, Kurucz et al., 2007)
              draper
              (Campbell et al., 2021, Arora and Ligoxygakis, 2020, Yalonetskaya et al., 2020, Hao et al., 2018, Ray et al., 2017, Winfree et al., 2017, Purice et al., 2016, Perkins et al., 2015, Tasdemir-Yilmaz and Freeman, 2014, Etchegaray et al., 2012, Logan et al., 2012, Rhiner et al., 2010, Doherty et al., 2009, Hashimoto et al., 2009, Kuraishi et al., 2009, Martín et al., 2009, Bejarano et al., 2008, Cuttell et al., 2008, Franc et al., 2008, Kuraishi et al., 2007, Li and Baker, 2007, Li and Baker, 2007, Awasaki et al., 2006, MacDonald et al., 2006, Williams et al., 2006, Qin et al., 2005, Freeman et al., 2001)
              Secondary FlyBase IDs
              • FBgn0035261
              Datasets (0)
              Study focus (0)
              Experimental Role
              Project
              Project Type
              Title
              References (209)